Asthma Status and Risks among Lesbian, Gay, and Bisexual Adults in the United States: A Scoping Review
Asthma is uncontrolled in up to 71% of adolescents and adults,1 resulting in higher healthcare costs, more school and work absences, and higher mortality.1,2 Sexual minority adults (SM; e.g., people who identify as lesbian, gay, or bisexual, or who have same-sex partners) have higher rates of asthma than heterosexual counterparts.3,4 However, it is unclear whether rates and risk factors differ by sexual identity. To address this critical knowledge gap, we conducted a scoping review to systematically search relevant literature following current guidelines. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 2, 2019 Category: Allergy & Immunology Authors: Cindy B. Veldhuis, Jean-Marie Bruzzese, Tonda L. Hughes, Maureen George Tags: Letters Source Type: research

Asthma status and risks among lesbian, gay, and bisexual adults in the United States
Asthma is uncontrolled in up to 71% of adolescents and adults,1 resulting in higher health care costs, more school and work absences, and higher mortality.1,2 Sexual minority (SM) adults (eg, people who identify as lesbian, gay, or bisexual or who have same-sex partners) have higher rates of asthma than their heterosexual counterparts.3,4 However, it is unclear whether rates and risk factors differ by sexual identity subgroups (eg, bisexual, men, lesbian). To address this critical knowledge gap, we conducted a scoping review to systematically search relevant literature following current guidelines. (Source: Annals of Aller...
Source: Annals of Allergy, Asthma and Immunology - February 2, 2019 Category: Allergy & Immunology Authors: Cindy B. Veldhuis, Jean-Marie Bruzzese, Tonda L. Hughes, Maureen George Tags: Letter Source Type: research

Presentation and natural history of progestogen hypersensitivity.
CONCLUSION: Although the medical literature on progestogen hypersensitivity is limited to case reports and small case series, significant heterogeneity exists in clinical presentation among patients. PMID: 30712576 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Foer D, Buchheit KM Tags: Ann Allergy Asthma Immunol Source Type: research

Associations of unsafe, unsupportive, and underdeveloped neighborhoods with atopic dermatitis in US children.
CONCLUSION: US children residing in unsafe, unsupportive, or underdeveloped neighborhoods have higher prevalence and severity of AD. PMID: 30712577 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: McKenzie C, Silverberg JI Tags: Ann Allergy Asthma Immunol Source Type: research

Coexistent TBX1 mutation and chromosomal 20q13.13-q13.2 duplication in an infant with abnormal T-cell receptor rearrangement circle newborn screening results.
PMID: 30712578 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Lam JK, Braddock SR, Huddleston CB, Knutsen AP Tags: Ann Allergy Asthma Immunol Source Type: research

The Best of 2018 in the Annals of Allergy, Asthma, and Immunology: The Editors' Choices.
PMID: 30711033 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Marshall GD, Leung DYM, Ellis A, Nowak-Wegrzyn A, Castells M, Grayson M, Greenhawt M, Lieberman J, Oppenheimer J, Spergel J Tags: Ann Allergy Asthma Immunol Source Type: research

Sex and allergic diseases.
PMID: 30711034 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Nowak-Wegrzyn A, Ellis A, Castells M Tags: Ann Allergy Asthma Immunol Source Type: research

Author's reply.
PMID: 30711035 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Scherzer R Tags: Ann Allergy Asthma Immunol Source Type: research

A critical need: Increasing interest in the field of allergy and immunology.
PMID: 30711036 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Okafor L, Nathan M Tags: Ann Allergy Asthma Immunol Source Type: research

Is hereditary angioedema related to an increased risk of atherosclerosis?
PMID: 30711037 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Bassareo PP, Firinu D, Del Giacco S Tags: Ann Allergy Asthma Immunol Source Type: research

A critical need
We read with interest Dr Scherzer ’s1 article on the downward trend in applicants for allergy and immunology (AI) fellowship programs, and we commend Dr Scherzer for exploring approaches to increase interest. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Authors: Lauren Okafor, Miriam Nathan Tags: Correspondence Source Type: research

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This book is part of a series that provides detailed reviews of advances in specific immunologic topics. It is divided into 5 chapters authored by experts in the field: 1) Eosinophil Development, Disease Involvement, and Therapeutic Suppression; 2) Unexpected Roles for Intracellular Complement in the Regulation of Th1 Responses; 3) Chemokines: Critical Regulators of Memory T Cell Development, Maintenance, and Function; 4) Molecular Classification of Primary Immunodeficiencies of T Lymphocytes; 5) Molecular Aspects of Allergens and Allergy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Authors: Jennifer R. Yonkof, Mitchell Grayson Tags: Book Review Source Type: research

Is hereditary angioedema related to an increased risk of atherosclerosis?
We paid close attention in reading the interesting paper by Nebenf ührer et al,1 whose findings excluded the presence of endothelial dysfunction in hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) patients. Their results are opposite of those recently published by our research group.2 Because the issue is important, impaired endothelial function be ing correlated with future occurrences of adverse cardiovascular events and cardiac death,3 we think that a few points should be worthy of debate. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Authors: Pier Paolo Bassareo, Davide Firinu, Stefano Del Giacco Tags: Correspondence Source Type: research

Author's reply
I thank Okafor et  al for their interest in our article “A Critical Need: Increasing Interest in the Field of Allergy and Immunology in Medical Students and Residents” and their thoughtful questions. The general downward trend in the number of candidates per fellowship position in the Allergy and Immunology (AI) fellowship training program match from 1.7 in 2008 to 1.0 in 2018 is concerning and an area of discussion and planning for many in the field.1,2 A study by Macy et al3 revealed that the key time in the decision-making process on whether to pursue fellowship training could be in the final years...
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Authors: Rebecca Scherzer Tags: Correspondence Source Type: research

The Best of 2018 in the Annals of Allergy, Asthma, and Immunology
The editors of the Annals of Allergy, Asthma, and Immunology considered more than 750 submissions for publication in 2018. From that number, we accepted 323 articles, letters, and other features to be included in the 12 issues of the 2018 Annals. Every feature was carefully scrutinized before acceptance, and there were multiple articles that were acceptable but were not used because of space constraints (ie, we do not have room to publish all of the acceptable manuscripts we received). Accordingly, the 323 are already the “best” of the submissions that were submitted last year. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Authors: Gailen D. Marshall, Donald Y.M. Leung, Anne Ellis, Anna Nowak-Wegrzyn, Marianna Castells, Mitchell Grayson, Matthew Greenhawt, Jay Lieberman, John Oppenheimer, Jonathan Spergel Tags: A Year in Review Source Type: research

Sex and allergic diseases
Differences between women and men are pervasive in human biology, including the immune system.1 The direct effects of sex hormones have not been comprehensively evaluated; however, lymphocytes, monocytes, eosinophils, basophils, and mast cells are known to express receptors for sex hormones.2 There is also evidence to suggest that estrogens act as enhancers of humoral responses, autoimmunity, mast cell reactivity, and delayed type IV allergic reactions, whereas androgens, progesterone, and glucocorticoids may have an immunosuppressive effect. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Authors: Anna Nowak-Wegrzyn, Anne Ellis, Mariana Castells Tags: Editorial Source Type: research

Information for Readers
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Source Type: research

Table of Contents
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Source Type: research

Information for Authors
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Source Type: research

Editorial Board
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 30, 2019 Category: Allergy & Immunology Source Type: research

"To Biologic or Not to Biologic?: The Question of Cost-Effectiveness".
"To Biologic or Not to Biologic?: The Question of Cost-Effectiveness". Ann Allergy Asthma Immunol. 2019 Jan 28;: Authors: Anderson WC, Szefler SJ PMID: 30703438 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2019 Category: Allergy & Immunology Authors: Anderson WC, Szefler SJ Tags: Ann Allergy Asthma Immunol Source Type: research

Economic burden of food allergy- A systematic review.
PMID: 30703439 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2019 Category: Allergy & Immunology Authors: Bilaver LA, Doshi P, Chadha AS, O'Dweyer L, Gupta RS Tags: Ann Allergy Asthma Immunol Source Type: research

Economic burden of food allergy- A systematic review
Food allergy (FA) is a life-threatening condition that is a growing health concern worldwide. Currently in the United States, 8% of children have a parent-reported FA.1 Much of the epidemiological work on FA has focused primarily on children; however, recent estimates have found that 10.8% of adults in the US have a self-reported FA.2 Furthermore, numerous studies have estimated the prevalence of FA in children from countries across Europe including France (6.7%),3 Greece (5.2%),4 and Sweden (6.8%). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2019 Category: Allergy & Immunology Authors: Lucy A. Bilaver, Priyam Doshi, Avneet S. Chadha, Linda O ’Dweyer, Ruchi S. Gupta Tags: Review Source Type: research

“To Biologic or Not to Biologic?: The Question of Cost-Effectiveness”
As of 2018, the FDA had approved five biologics for the treatment of asthma – omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab. All five of these biologics are designated for the treatment of severe asthma in patients with a TH2-driven phenotype, either allergic or eosinophilic. In clinical trials, biologics have demonstrated efficacy to decrease the frequ ency of asthma exacerbations, unplanned health utilization including ED visits and hospitalizations, and chronic oral steroid use in severe asthmatic patients1. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2019 Category: Allergy & Immunology Authors: William C. Anderson, Stanley J. Szefler Tags: Review Source Type: research

Economic burden of food allergy
To assess the economic burden of food allergy (FA) worldwide. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2019 Category: Allergy & Immunology Authors: Lucy A. Bilaver, Avneet S. Chadha, Priyam Doshi, Linda O'Dwyer, Ruchi S. Gupta Tags: Review Source Type: research

Cost-effectiveness and comparative effectiveness of biologic therapy for asthma
To evaluate relevant studies and documents that address the cost-effectiveness and comparative effectiveness of biologics current approved by the US Food and Drug Administration for the treatment of asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 28, 2019 Category: Allergy & Immunology Authors: William C. Anderson, Stanley J. Szefler Tags: Review Source Type: research

From the pages of AllergyWatch.
PMID: 30685561 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Oppenheimer JJ, Lang DM, Fineman SM Tags: Ann Allergy Asthma Immunol Source Type: research

Chronic Itch Management: Therapies Beyond Those Targeting the Immune System.
PMID: 30685562 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Fowler E, Yosipovitch G Tags: Ann Allergy Asthma Immunol Source Type: research

Pattern of Medication Use in Children with Very Poorly Controlled Asthma.
PMID: 30685563 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Butz AM, Morphew T, Bellin M, Bollinger ME, Tsoukleris M Tags: Ann Allergy Asthma Immunol Source Type: research

From the pages of AllergyWatch
J Allergy Clin Immunol Pract. 2018;6:1274-1286 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2019 Category: Allergy & Immunology Authors: John J. Oppenheimer, David Michael Lang, Stanley M. Fineman Source Type: research

Chronic Itch Management: Therapies Beyond Those Targeting the Immune System
Itch, a sensation that leads to a desire to scratch, becomes chronic when it persists for more than 6 weeks.1 Chronic itch can be debilitating and lead to a significantly reduced quality of life. It affects sleep, mood, and can cause symptoms of anxiety and depression.2 Pruritus may be perpetuated by inflammatory conditions, as seen in atopic dermatitis and psoriasis. However, chronic pruritus may not always have an inflammatory component, and therefore requires treatments that do not work on the immune system, but instead target the nerves. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Emilie Fowler, Gil Yosipovitch Tags: Review Source Type: research

Pattern of Medication Use in Children with Very Poorly Controlled Asthma
Tables: 1 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2019 Category: Allergy & Immunology Authors: Arlene M. Butz, Tricia Morphew, Melissa Bellin, Mary Elizabeth Bollinger, Mona Tsoukleris Tags: Letters Source Type: research

A Peripheral Cause of Asthma: Peripheral T-cell Lymphoma.
PMID: 30684735 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Ramonell RP, Kuruvilla M, Sica G, Bag R, Eun-Hyung Lee F Tags: Ann Allergy Asthma Immunol Source Type: research

Ethanol LOCK & Immunoglobulin LOAD: Improving the Clinical Course of Tricho-hepato-enteric Syndrome.
Ethanol LOCK & Immunoglobulin LOAD: Improving the Clinical Course of Tricho-hepato-enteric Syndrome. Ann Allergy Asthma Immunol. 2019 Jan 23;: Authors: Popadiuk CA, Lindsey DR, Jones MU, Mikita CP PMID: 30684736 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Popadiuk CA, Lindsey DR, Jones MU, Mikita CP Tags: Ann Allergy Asthma Immunol Source Type: research

The Evaluation of Tryptase after Subcutaneous Immunotherapy-Associated Systemic Reactions.
PMID: 30684737 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Szari S, Wong PH, Crisp HC, Champoux E, Rans TS, Coop CA Tags: Ann Allergy Asthma Immunol Source Type: research

Disparities persist in asthma-related emergency department visits among Chicago children.
PMID: 30684738 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Volerman A, Kan K, Salem E, Prachand N, Warren CM, Sighoko D, Gupta RS Tags: Ann Allergy Asthma Immunol Source Type: research

New IgE Immediate Hypersensitivity Reactions Upon Reintroduction of Food Restricted for Treatment of Eosinophilic Esophagitis.
PMID: 30684739 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Gottlieb SJ, Markowitz JE, Dellon ES Tags: Ann Allergy Asthma Immunol Source Type: research

A Peripheral Cause of Asthma: Peripheral T-cell Lymphoma
We report a case of new-onset asthma with peripheral eosinophilia, subsequently diagnosed with PTCL, highlighting the need to consider a broad differential in the setting of uncontrolled atypical respiratory symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Richard P. Ramonell, Merin Kuruvilla, Gabriel Sica, Remzi Bag, F. Eun-Hyung Lee Tags: Letters Source Type: research

New IgE Immediate Hypersensitivity Reactions Upon Reintroduction of Food Restricted for Treatment of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic immune mediated disease. As EoE is largely food driven, elimination diets (ED) are one of the two primary modalities used to treat EoE 1,2 Options include empiric EDs (6, 4, or 2 food EDs) or targeted EDs based on food allergy testing.3,4 Recently, children with EoE have been reported to develop immediate hypersensitivity reactions with reintroduction of previously IgE tolerated milk.5,6,7,8 Herein, anaphylaxis to previously tolerated wheat in an adult with EoE, and diffuse urticaria from soy reintroduction in a teen with EoE are presented. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Steven J. Gottlieb, Jonathan E. Markowitz, Evan S. Dellon Tags: Letters Source Type: research

Disparities persist in asthma-related emergency department visits among Chicago children
This study examines trends in asthma-related ED visits among Chicago children since 2009, with a particular focus on assessing racial and ethnic disparities, which previous work indicates may be substantial. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Anna Volerman, Kristin Kan, Erica Salem, Nik Prachand, Chris M. Warren, Dominique Sighoko, Ruchi S. Gupta Tags: Letters Source Type: research

Ethanol LOCK & Immunoglobulin LOAD: Improving the Clinical Course of Tricho-hepato-enteric Syndrome
The patient is a 3 year old female with tricho-hepato-enteric syndrome (THE-S) admitted for an Escherichia-coli central line associated bloodstream infection. Medical history includes chronic diarrhea (baseline 4-5 loose stools per day) with total parenteral nutrition (TPN) via central line, failure to thrive (FTT), reno-vascular hypertension, iron deficiency anemia, liver impairment, multiple line infections, and pneumonia. She was born via cesarean section at 35 weeks estimated gestational age (EGA) due to intrauterine growth restriction (IUGR). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Catherine A. Popadiuk, Diana R. Lindsey, Milissa U. Jones, Cecilia P. Mikita Tags: Letters Source Type: research

The Evaluation of Tryptase after Subcutaneous Immunotherapy-Associated Systemic Reactions
The opinions or assertions herein are the private views of the authors and are not to be construed as reflecting the views of the Department of the Air Force or the Department of Defense. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Sofia szari, Priscilla H. Wong, Howard C. Crisp, Edward Champoux, Tonya S. Rans, Christopher A. Coop Tags: Letters Source Type: research

A peripheral cause of asthma
We report a case of new-onset asthma with peripheral eosinophilia, subsequently diagnosed with PTCL, highlighting the need to consider a broad differential in the setting of uncontrolled atypical respiratory symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Richard P. Ramonell, Merin Kuruvilla, Gabriel Sica, Remzi Bag, F. Eun-Hyung Lee Tags: Letters Source Type: research

New IgE immediate hypersensitivity reactions on reintroduction of food restricted for treatment of eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease. Because EoE is largely food driven, elimination diet (ED) is 1 of the 2 primary modalities used to treat EoE1,2 Options include empiric EDs (6, 4, or 2 food EDs) or targeted EDs based on food allergy testing.3,4 Recently, children with EoE have been reported to develop immediate hypersensitivity reactions with reintroduction of previously immunoglobulin E (IgE) tolerated milk.5 –8 Herein, anaphylaxis to previously tolerated wheat in an adult with EoE, and diffuse urticaria from soy reintroduction in a teen with EoE are presented. (Source: Annals of ...
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Steven J. Gottlieb, Jonathan E. Markowitz, Evan S. Dellon Tags: Letters Source Type: research

Ethanol lock and immunoglobulin load
A 3-year-old girl with trichohepatoenteric syndrome (THE-S) was admitted for an Escherichia coli central catheter –associated bloodstream infection. Her medical history includes chronic diarrhea (baseline of 4-5 loose stools per day) with total parenteral nutrition (TPN) via central catheter, failure to thrive (FTT), renovascular hypertension, iron deficiency anemia, liver impairment, multiple catheter infect ions, and pneumonia. She was born via cesarean section at an estimated gestational age of 35 weeks because of intrauterine growth restriction. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Catherine A. Popadiuk, Diana R. Lindsey, Milissa U. Jones, Cecilia P. Mikita Tags: Letters Source Type: research

Evaluation of tryptase after subcutaneous immunotherapy –associated systemic reactions
Tryptase is an objective marker of mast cell burden and degranulation that is often released in conjunction with other mediators during anaphylaxis, resulting in transient elevation.1,2 In addition to elevations in absolute total tryptase levels, a few alternate definitions of tryptase levels elevations have been proposed, including an increase of 135%,3 a peak (SD) peak serum tryptase level of more than 2 + 1.2 times the baseline tryptase level,4 and more recently a reaction to baseline ratio of greater than 2.99. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Sofia Szari, Priscilla H. Wong, Howard C. Crisp, Edward Champoux, Tonya S. Rans, Christopher A. Coop Tags: Letter Source Type: research

Concomitant hypersensitivity pneumonitis and occupational asthma caused by 2 different etiologic agents
Bronchial asthma is a chronic respiratory disease caused by an inflammatory response of the airway that causes bronchial hyperresponsiveness and variable obstruction to airflow, which is usually reversible.1 Hypersensitivity pneumonitis (HP) occurs as a consequence of an inflammatory response that damages the bronchoalveolar tissue and the pulmonary interstitium.2 Environmental factors are usually involved in the development of both entities; however, in each disease, different immunologic pathways have been implicated. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2019 Category: Allergy & Immunology Authors: Elena Solana, Maria-Jesus Cruz, Christian Romero-Mesones, Xavier Mu ñoz Tags: Letters Source Type: research

Oral Challenge Outcomes in Children with Adverse Aminopenicillin Reactivity.
PMID: 30641194 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2019 Category: Allergy & Immunology Authors: Ellis AG, Bloomberg G Tags: Ann Allergy Asthma Immunol Source Type: research

Concomitant hypersensitivity pneumonitis and occupational asthma caused by two different etiological agents.
;oz X PMID: 30641195 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2019 Category: Allergy & Immunology Authors: Solana E, Cruz MJ, Romero-Mesones C, Muñoz X Tags: Ann Allergy Asthma Immunol Source Type: research

Another Look at Cyclosporine for Treating Antihistamine-Resistant Chronic Spontaneous Urticaria.
PMID: 30641196 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 11, 2019 Category: Allergy & Immunology Authors: Weinberger M Tags: Ann Allergy Asthma Immunol Source Type: research