Drug rash with eosinophilia and systemic symptoms (dress) syndrome hypersensitivity myocarditis presenting with cardiogenic shock
We report a case of suspected DRESS myocarditis presenting with cardiogenic shock. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Karagic, G. De Vos Tags: M059 Source Type: research

Immediate reaction after methotrexate and vincristine with urgent and prolonged intermittent need for the drugs
Immediate reactions to methotrexate (MTX) and vincristine (VCR) are rare. Proposed mechanisms include IgE mediated and anaphylactoid. In a case series, VCR was tolerated after immediate reactions. Given common use of MTX as a first-line chemotherapeutic agent, urgent action and further evaluation is useful. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: N. Wolfset, M. Ford Tags: M060 Source Type: research

Cannabis allergy in a young child with severe asthma exposed to secondhand marijuana smoke
We present a case of cannabis allergy associated with secondhand cannabis exposure and highlight its potential impact on childhood asthma. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: B. Hoffman, M. Kuhl, V. Knight, M. Phillips, N. Rabinovitch Tags: M076 Source Type: research

Prolonged hypereosinophilia in rett syndrome patient secondary to environmental allergy
The major goal for hypereosinophilia workup is to identify disorders that require treatment and to prevent organ damage. Our case presents unexplained hypereosinophilia which led to an extensive workup for years. It was unexplained until an environmental intervention performed by the family resulted in sustained resolution of the hypereosinophilia. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Patel, R. Zemble, K. Buzard Tags: M077 Source Type: research

A case of idiopathic anaphylaxis: a 4-year odyssey
Idiopathic anaphylaxis is rare and only diagnosed after a thorough evaluation. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Marin-Acevedo, E. Gilbert, C. Rivera, A. Gonzalez-Estrada Tags: M100 Source Type: research

A rare cause of angioedema with treatment leading to resolution of cutaneous symptoms
Urticarial vasculitis (UV) manifestations range from urticaria to systemic vasculitis. Serious cases are associated with hypocomplementemia in which immune complexes deposit in multiple sites called Hypocomplementemic Urticarial Vasculitis Syndrome (HUVS). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: N. Scanlon, M. Shams Tags: M150 Source Type: research

Not your average case of angioedema
Allergists are commonly consulted for management of angioedema in hospitalized patients. It is also an opportunity for the allergist to assess for and recognize other causes of life-threatening swelling. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: D. Cohn, M. Mahdavinia Tags: M151 Source Type: research

An index case of a rare form of inducible urticaria successfully treated with omalizumab
Inducible urticarias such as cholinergic or adrenergic urticaria (AU) can be challenging to control. Herein, we report an index case of AU successfully treated with omalizumab. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Greiwe Tags: M152 Source Type: research

Patient with lymphoma and acquired angioedema: navigating the blurred lines in diagnosis and treatment
In acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE), the gastrointestinal (GI) tract is a common site of angioedema attack. Abdominal involvement occurring by itself is difficult to diagnose as it may masquerade as other GI pathologies, including acute surgical abdomen. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: C. Smigiel, E. Chen, L. Banka, M. Li, L. Scott, K. Kwong Tags: M153 Source Type: research

Prolonged angioedema following bot fly infestation
We report a unique case of myiasis in a patient who presented with urticaria and angioedema. Angioedema in the context of myiasis is not well described in literature.Angioedema (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: R. Patel, E. Perez, A. Koterba Tags: M154 Source Type: research

A case of refractory recurrent cyclical angioedema and urticaria successfully treated with multiple steps therapy
We report a case of refractory PH successfully controlled with multiple steps therapy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: V. Gadoury-Levesque, J. Bernstein Tags: M155 Source Type: research

"am i allergic to the ocean?": hives in a young vacationing girl
Saline-dependent aquagenic urticaria (SDAU) is a rare form of aquagenic urticaria with Typically 1-3 mm papular lesions, these hives are distributed on the face and neck, affecting mostly adolescent to middle aged women. Onset is usually within 20 minutes of exposure, with resolution within 30 minutes after discontinued exposure. Treatment with antihistamines is typically unsuccessful. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Lutzkanin, N. Bhardwaj Tags: M156 Source Type: research

To the heart of the matter: large pericardial effusion causing severe facial angioedema
Angioedema is triggered by deep dermal, subcutaneous and submucosal vascular leakage that results in visible, nonpitting swelling. Subacute or chronic facial edema may be due to histamine or bradykinin-mediated angioedema, but alternate causes should be considered when symptoms are atypical or unresponsive to therapy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: R. Alkatib, T. Carr Tags: M157 Source Type: research

Acute urticaria: is there more under the itch?
Acute urticaria is a common disease and often the etiology is never identified. Allergic, infectious, rheumatologic, and malignant etiologies are known but testing is generally not conducted. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Straesser, T. Kyin, A. Smith Tags: M158 Source Type: research

A tongue twister – macroglossia or angioedema of the tongue?
Macroglossia is “unusual enlargement of the tongue”. It may be difficult to distinguish from angioedema affecting the tongue. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Daley, M. Henao, G. Ghaffari Tags: M159 Source Type: research

Acquired angioedema – an unusual presentation of systemic lupus erythematosus
We present a patient with recurrent angioedema that was found to have systemic lupus erythematosus (SLE). Angioedema was her only presenting symptom. She denied other common signs and symptoms of SLE. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: V. Menashy, J. McCracken Tags: M161 Source Type: research

Not all lip swelling is angioedema
Cheilitis granulomatosa (CG) is a rare form of recurrent or persistent swelling of one or both lips and one form of orofacial granulomatosis. It is important for allergists to consider the need for mucosal biopsy in patients initially referred for angioedema, especially if the lip swelling has been persistent. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: H. Stern, M. Henao, G. Ghaffari Tags: M162 Source Type: research

When edema isn't angioedema: superior vena cava syndrome as a confounder in hereditary angioedema
We report the case of a patient with known HAE complicated by concomitant SVC syndrome. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: C. Dixit, S. LeBlanc, L. Buchanan, L. Aldred, L. Behlen, P. Stewart Tags: M163 Source Type: research

Recurrent angioedema as a presenting symptom of mixed connective tissue disease in a pediatric patient
We present a patient who was diagnosed with mixed connective tissue disease (MCTD) after initially presenting with recurrent angioedema. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Polcari, J. Freeman, A. CaJacob, C. Crayne Tags: M164 Source Type: research

Screening for hereditary angioedema in infancy
We describe a case of a 4-month-old boy who required screening for HAE. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: G. Patel, M. Pasha Tags: M165 Source Type: research

Conditions mimicking angioedema: suspecting alternative causes of swelling in clinic
Patients are often referred to Allergy and Immunology for an evaluation of swelling. An awareness of the clinical features of angioedema will aid clinicians in establishing the correct diagnosis. This is illustrated by two cases at the University of Pennsylvania Allergy and Immunology Clinic involving cutaneous and mucous membrane swelling due to unrecognized systemic diseases. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: P. Gleeson, O. Fadugba Tags: M166 Source Type: research

Hereditary angioedema precipitated by constipation secondary to stimulant medication use
Hereditary angioedema (HAE) is an inherited condition manifesting as recurrent episodes of swelling that commonly affects the skin and gastrointestinal tract (1,8). Various triggers can be the precipitating factors in an acute episode of HAE, however, sometimes the culprit cannot be determined. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Cardenas-Morales, Y. Chang, W. Blouin, V. Hernandez-Trujillo Tags: M167 Source Type: research

Refractory abdominal wall angioedema in a young female with known hereditary angioedema
We present an unusual cause of refractory abdominal wall angioedema. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: C. Rigell Tags: M168 Source Type: research

Subcutaneous c1-inhibitor for long-term prophylaxis in hereditary angioedema with normal c1 inhibitor
Hereditary angioedema (HAE) is a rare disorder characterized by episodes of swelling without urticaria. HAE presents with decreased C1 inhibitor (C1INH) antigen (type I) or function (type II), or with normal C1INH (HAE-nC1INH). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Kalamaha, H. Fernandes, M. Riedl, J. Rodrigues Tags: M169 Source Type: research

Is it angioedema or air?
Angioedema can present with acute facial and upper airway swelling that may be potentially life threatening. Diagnosis is made clinically based on history and exam findings. In patients with concern of airway compromise, immediate airway protection and treatment is indicated. It is important to evaluate for mimickers of angioedema which may have similar presentations but differing treatments.Periorbital edema Photograph of patient taken on day of admission (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: S. Chu, M. Dykewicz, R. Slavin, S. Powell, J. Lam Tags: M170 Source Type: research

An unusual infectious cause of acute urticaria
Although many cases of acute urticaria are caused by infectious illnesses, certain pathogens are not frequently reported in association with urticaria.Urticaria (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Gereige, K. Hysell, K. Reynolds, M. Guenechea-Sola Tags: M171 Source Type: research

Delayed urticaria and angioedema following yellow fever vaccine immunization
We present a case of delayed urticaria and angioedema (U&A) following YFV immunization. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Beronilla, M. Karagic, G. Hudes Tags: M172 Source Type: research

Rock, paper, scissors, asthma, bronch: rock beats asthma
We present a case of broncholithiasis and treatment with bronchoscope removal. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: H. Ahmad, A. Gonzalez-Estrada Tags: M200 Source Type: research

Hypersensitivity pneumonitis due to an outdoor antigen in the home
We present a case of HP to an external avian antigen that became present in the home. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: N. Agnihotri, G. Patel, P. Greenberger Tags: M201 Source Type: research

Differential diagnosis in pediatric severe asthma
Despite drug treatment, a small percentage of patients with asthma cannot reach control. Therefore, it is important to have differential diagnosis in mind. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Cardoza-Arteche, Z. Flores-Aldape, C. Pozo-Beltran Tags: M202 Source Type: research

Combination biologic therapy in severe asthma: a case series
We report three cases in which dual biologic therapy was pursued due to lack of control on biologic monotherapy. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: R. Thomes, J. Darveaux Tags: M203 Source Type: research

Uncontrolled severe persistent asthma: more than meets the eye
We present a case of poorly controlled asthma related to an unsuspected cause. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: R. D'Mello, S. Alvarado, S. Bahna Tags: M204 Source Type: research

An unusual case of a rare diagnosis mimicking asthma.
A patient with decreased airflow on chest auscultation, with progressive shortness of breath, dry cough, even in the absence of chest pain, may mimic asthma. A diagnosis of pneumothorax might be delayed if a chest X-ray is not done. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: S. Nsouli Tags: M205 Source Type: research

Breathing for two: a case of severe eosinophilic asthma during pregnancy treated with benralizumab
The following is a case of severe eosinophilic asthma during pregnancy treated with benralizumab. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: T. Saco, F. Tabatabaian Tags: M206 Source Type: research

Refractory asthma in a 14 year old asian male
Diffuse panbronchiolitis (DPB) is a rare inflammatory disease of the lung with poor prognosis if left untreated. It is a primarily Th1 driven process with involvement of CD8+ lymphocytes and neutrophils driving inflammation in the respiratory tract. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Liu, P. Ong Tags: M207 Source Type: research

Use of omalizumab in four-year-old with severe persistent allergic asthma
We report use of omalizumab for the treatment of uncontrolled asthma in a 4-year-old. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: G. Patel, M. Pasha Tags: M208 Source Type: research

Late-onset cystic fibrosis in an elderly male
We describe a man with history of infertility and recurrent bronchitis who was diagnosed with CF at age 69. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: X. Chen, N. Canon, J. Hajjar Tags: M209 Source Type: research

Gastroesophageal reflux (gerd): a major factor in highly labile steroid-dependent asthma
In the setting of severe asthma with difficult to control symptoms, it is crucial to evaluate for other diagnoses and comorbidities in order to optimize management. In the case presented, sub-optimally treated GERD was identified as the driving force causing severe asthma symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Meyer, S. Gupta, N. Rabinovitch, P. Hauk, J. Abbott Tags: M210 Source Type: research

Algorithm for the diagnosis and treatment of exercise-induced bronchospasm
Exercise-induced bronchospasm (EIB) is the acute onset of transient bronchoconstriction of the lower airways during or immediately following exercise. The prevalence of EIB in the general population is only 5-20% compared to up to 90% in asthmatic patients. In EIB, the initial bronchodilation from exercise is then followed by bronchoconstriction resulting in subsequent symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: S. Chan Tags: M211 Source Type: research

A surprising discovery - idiopathic hypereosinophilic syndrome
A 51-year old man with past medical history of allergic rhinitis was admitted to the hospital and treated for a right sided multi-lobar pneumonia. He presented with progressively worsening dry cough, malaise and diffuse (hip, knee, elbow, hands) joint pain. He had a history of multiple episodes of sinusitis and upper respiratory tract infections in the preceding six months requiring steroids and antibiotics with varying responses. A CBC revealed eosinophil count of> 9 eosinophils x 109/L. A BAL revealed over 90% eosinophils. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Faiz, B. Demirjian, J. Yusin Tags: M212 Source Type: research

Spectrum of immunodeficiencies in jacobsen syndrome
Jacobsen syndrome (JS) is a rare contiguous gene deletion syndrome associated with a distal deletion of chromosome 11q. Immune deficiency in JS has not been well-established but usually involves antibody defects. Here we report 2 cases of Jacobsen syndrome with combined T and B cell defects presenting at different ages. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: T. Banzon, Y. Demirdag Tags: M225 Source Type: research

A novel gene mutation associated with common variable immunodeficiency and pyoderma
We describe a novel mutation of the Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) associated with CVID and pyoderma gangrenosum. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: N. Joseph, R. Hostoffer, H. Tcheurekdjian Tags: M226 Source Type: research

An atypical presentation of selective immunoglubulin m (igm) deficiency
Selective IgM deficiency (SIGMD) remains a poorly described primary immunodeficiency. The condition is frequently under-recognized and no genetic defect has been identified to date. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: D. Padmanabhan Menon, I. Carrillo Martin, A. Gonzalez-Estrada Tags: M227 Source Type: research

A case of recurrent aspiration pneumonia and persistent eosinophilia
Homozygous or compound heterozygous loss-of-function (LOF) mutations in CARMIL2 are associated with combined immunodeficiency disorder with a variable phenotypic presentation in 10 families (21 patients). Clinical manifestations include recurrent skin and lung infections, dermatitis, chronic diarrhea, esophagitis, and failure-to-thrive. Here we describe a case of immune deficiency associated with an apparently homozygous, novel variant c.1942delC (p.His648ThrfsX20) in the CARMIL2 gene (RLTPR). (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Chan, J. Bassetti, E. Feuille Tags: M228 Source Type: research

Abnormal newborn screen in a whim syndrome patient
Newborn screen (NBS) for primary immunodeficiency is performed in the vast majority of states. Dried blood spots are collected from infants. The samples undergo quantitative PCR to quantify T cell receptor excision circles (TRECs). This screening detects Severe Combined Immunodeficiency (SCID) as well as hypomorphic mutations in SCID genes, conditions resulting in the arrest of T cell development such as DiGeorge syndrome and conditions presenting with T cell lymphopenia. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Evans, M. Petersen, D. McDermott, P. Murphy Tags: M229 Source Type: research

Genetic testing identifies cause of enteropathy and growth failure in a 10 year old male
Enteropathies with features of celiac disease or inflammatory bowel disease (IBD) should spark consideration of an immunodeficiency when presenting at an early age. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: C. Dunn, L. Moore Tags: M230 Source Type: research

Selective iga deficiency in a williams syndrome patient, an uncommon presentation of a common diagnosis
We present a patient with Williams Syndrome and recurrent infections since infancy who was not diagnosed with immunodeficiency until 7 years of age. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Perkins, A. Yates, L. Schmidt Tags: M231 Source Type: research

Respiratory distress, persistent oral candidiasis, draining kerion, skin abscesses, and onychomycosis in a 3-year-old male
We report a case of a 3-year-old Latino male who was seen over three years with three hospitalizations for Respiratory Distress. An initial immunodeficiency work-up was essentially normal. Despite a history of respiratory distress and respiratory allergy, the patient required further investigation into his immune system when he was noted to have four significant infections. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: B. Ariue, C. Enweasor Tags: M232 Source Type: research

Refractory pericarditis treated with concurrent subcutaneous immunoglobulin and interleukin 1 inhibitor therapy
Patients with refractory pericarditis have been treated with intravenous immunoglobulin or interleukin 1 (IL1) receptor antagonist (Anakinra) with limited success. Separate or combined therapy with subcutaneous immunoglobulin (HyQvia) and IL1 inhibitor (Rilonacept) for refractory pericarditis has not been previously described. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Gans, S. Gagne, D. Hsu, A. Rubinstein Tags: M233 Source Type: research

Complement deficiency in two patients with absence of t-cell receptor excision circles on newborn screening
Most states use T-Cell Receptor Excision Circle (TREC) assays in routine newborn screening to identify infants with T cell defects. Some of these low TREC infants have normal T cell counts and function, without evidence of clinically significant disease. However, some of these low TREC infants without evidence of T cell dysfunction may develop serious infections, necessitating further immune evaluation. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: M. Samstein, Y. Hamzavi Abedi, Z. Treyster, A. Jongco Tags: M234 Source Type: research