The impact of IL-10 and IL-17 on myeloid-derived suppressor cells in vitro and in vivo in a murine model of asthma
Eur J Immunol. 2024 Apr 23:e2350785. doi: 10.1002/eji.202350785. Online ahead of print.ABSTRACTMyeloid-derived suppressor cells (MDSCs) hold promise for clinical applications due to their immunosuppressive properties, particularly in the context of inflammation. In the present study, the number and immunosuppressive activity of MDSCs isolated from naïve Il10-/-, Il17-/-, and WT mice as control, as well as from house dust mite extract (HDM)-induced asthmatic Il10-/- and Il17-/- mice, were investigated. IL-10 deficiency increased the number of polymorphonuclear (PMN)-MDSCs in the lung, spleen, and bone marrow, without concu...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Charlotte Vetter Jakob Schieb Nora Vedder Tim Lange Tobias Brunn Chiel van Geffen Philipp Gercke Saeed Kolahian Source Type: research
SARS-CoV-2 infection induces thymic atrophy mediated by IFN- γ in hACE2 transgenic mice
Eur J Immunol. 2024 Apr 24:e2350624. doi: 10.1002/eji.202350624. Online ahead of print.ABSTRACTPathogenic infections cause thymic atrophy, perturb thymic T-cell development, and alter immunological response. Previous studies reported dysregulated T-cell function and lymphopenia in coronavirus disease-19 (COVID-19). However, immunopathological changes in the thymus associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have not been elucidated. Here, we report that SARS-CoV-2 infects thymocytes, and induces CD4+CD8+ (double positive; DP) T-cell apoptosis leading to thymic atrophy and loss of ...
Source: European Journal of Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Zaigham Abbas Rizvi Srikanth Sadhu Jyotsna Dandotiya Puja Sharma Akshay Binayke Virendra Singh Vinayaka Das Ritika Khatri Rajesh Kumar Sweety Samal Manjula Kalia Amit Awasthi Source Type: research
Temporal associations of plasma levels of the secreted phospholipase A < sub > 2 < /sub > family and mortality in severe COVID-19
Eur J Immunol. 2024 Apr 23:e2350721. doi: 10.1002/eji.202350721. Online ahead of print.ABSTRACTPrevious research suggests that group IIA-secreted phospholipase A2 (sPLA2-IIA) plays a role in and predicts lethal COVID-19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA2 isoforms and the severity of COVID-19 in 214 ICU patients. The levels of six secreted PLA2 isoforms, sPLA2-IIA, sPLA2-V, sPLA2-X, sPLA2-IB, sPLA2-IIC, and sPLA2-XVI, increased over the first 7 ICU days in those who succumbed to the disease but ...
Source: European Journal of Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Eric Lu Aki Hara Shudong Sun Brian Hallmark Justin M Snider Michael C Seeds Joseph C Watkins Charles E McCall Hao Helen Zhang Guang Yao Floyd H Chilton Source Type: research
Temporal associations of plasma levels of the secreted phospholipase A < sub > 2 < /sub > family and mortality in severe COVID-19
Eur J Immunol. 2024 Apr 23:e2350721. doi: 10.1002/eji.202350721. Online ahead of print.ABSTRACTPrevious research suggests that group IIA-secreted phospholipase A2 (sPLA2-IIA) plays a role in and predicts lethal COVID-19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA2 isoforms and the severity of COVID-19 in 214 ICU patients. The levels of six secreted PLA2 isoforms, sPLA2-IIA, sPLA2-V, sPLA2-X, sPLA2-IB, sPLA2-IIC, and sPLA2-XVI, increased over the first 7 ICU days in those who succumbed to the disease but ...
Source: European Journal of Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Eric Lu Aki Hara Shudong Sun Brian Hallmark Justin M Snider Michael C Seeds Joseph C Watkins Charles E McCall Hao Helen Zhang Guang Yao Floyd H Chilton Source Type: research
The immunosuppressive drug cyclosporin A has an immunostimulatory function in CD8 < sup > + < /sup > T cells
Eur J Immunol. 2024 Apr 22:e2350825. doi: 10.1002/eji.202350825. Online ahead of print.ABSTRACTCyclosporin A is a well-established immunosuppressive drug used to treat or prevent graft-versus-host disease, the rejection of organ transplants, autoimmune disorders, and leukemia. It exerts its immunosuppressive effects by inhibiting calcineurin-mediated dephosphorylation of the nuclear factor of activated T cells (NFAT), thus preventing its nuclear entry and suppressing T cell activation. Here we report an unexpected immunostimulatory effect of cyclosporin A in activating the mammalian target of rapamycin complex 1 (mTORC1), ...
Source: European Journal of Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Jannis Wi ßfeld Marvin Hering Nora Ten Bosch Guoliang Cui Source Type: research
Cenicriviroc, a CCR2/CCR5 antagonist, promotes the generation of type 1 regulatory T cells
This study is the first to report that Cenicriviroc promotes Tr1 cell generation by up-regulating the signature of Tr1 cell transcription factors such as c-Maf, Prdm1, Irf-1, Batf, and EGR-2. Cenicriviroc displayed a protective effect in experimental colitis models by preventing body weight loss and intestinal inflammation and preserving epithelial barrier integrity. We show that Cenicriviroc induced IL-10 and inhibited the generation of pro-inflammatory cytokines IFN-γ, IL-17, IL-6, and IL-1β during colitis. Based on our data, we propose Cenicriviroc as a potential therapeutic in controlling tissue inflammation by inhib...
Source: European Journal of Immunology - April 21, 2024 Category: Allergy & Immunology Authors: Upasna Madan Bhawna Verma Amit Awasthi Source Type: research
MicroRNAs targeting TGF- β signaling exacerbate central nervous system autoimmunity by disrupting regulatory T cell development and function
Eur J Immunol. 2024 Apr 18:e2350548. doi: 10.1002/eji.202350548. Online ahead of print.ABSTRACTTransforming growth factor beta (TGF-β) signaling is essential for a balanced immune response by mediating the development and function of regulatory T cells (Tregs) and suppressing autoreactive T cells. Disruption of this balance can result in autoimmune diseases, including multiple sclerosis (MS). MicroRNAs (miRNAs) targeting TGF-β signaling have been shown to be upregulated in naïve CD4 T cells in MS patients, resulting in a limited in vitro generation of human Tregs. Utilizing the murine model experimental autoimmune encep...
Source: European Journal of Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Christina N Rau Mary E Severin Priscilla W Lee Joshua L Deffenbaugh Yue Liu Shawn P Murphy Cora L Petersen-Cherubini Amy E Lovett-Racke Source Type: research
Combining SARS-CoV-2 interferon-gamma release assay with humoral response assessment to define immune memory profiles
CONCLUSION: The discrepancy between humoral and cellular responses highlights the significance of assessing the overall adaptive immune response. This integrated approach allows the identification of vulnerable subjects and can be of interest to guide antiviral prophylaxis at an individual level.PMID:38627984 | DOI:10.1002/eji.202451035 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: William Mouton Guy Oriol Christelle Compagnon Carla Saade Kahina Saker Priscille Franc Bouchra Mokdad Aurore Fleurie Xavier Lacoux Soizic Daniel Franck Berthier C écile Barnel Bruno Pozzetto Jean-Baptiste Fassier Val érie Dubois Sophia Djebali Maxence D Source Type: research
Canonical and noncanonical functions of complement in systemic lupus erythematosus
Eur J Immunol. 2024 Apr 17:e2350918. doi: 10.1002/eji.202350918. Online ahead of print.ABSTRACTFor many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function(s) of complement remains an important challenge for the future and has implications for the use of complem...
Source: European Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Matthew C Pickering Marina Botto Source Type: research
Combining SARS-CoV-2 interferon-gamma release assay with humoral response assessment to define immune memory profiles
CONCLUSION: The discrepancy between humoral and cellular responses highlights the significance of assessing the overall adaptive immune response. This integrated approach allows the identification of vulnerable subjects and can be of interest to guide antiviral prophylaxis at an individual level.PMID:38627984 | DOI:10.1002/eji.202451035 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: William Mouton Guy Oriol Christelle Compagnon Carla Saade Kahina Saker Priscille Franc Bouchra Mokdad Aurore Fleurie Xavier Lacoux Soizic Daniel Franck Berthier C écile Barnel Bruno Pozzetto Jean-Baptiste Fassier Val érie Dubois Sophia Djebali Maxence D Source Type: research
Canonical and noncanonical functions of complement in systemic lupus erythematosus
Eur J Immunol. 2024 Apr 17:e2350918. doi: 10.1002/eji.202350918. Online ahead of print.ABSTRACTFor many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function(s) of complement remains an important challenge for the future and has implications for the use of complem...
Source: European Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Matthew C Pickering Marina Botto Source Type: research
Empowering γδ T-cell functionality with vitamin C
Eur J Immunol. 2024 Apr 15:e2451028. doi: 10.1002/eji.202451028. Online ahead of print.ABSTRACTVitamin C (ascorbic acid) is a potent antioxidant and a cofactor for various enzymes including histone demethylases and methylcytosine dioxygenases. Vitamin C also exerts direct cytotoxicity toward selected tumor cells including colorectal carcinoma. Moreover, vitamin C has been shown to impact immune cell differentiation at various levels including maturation and/or functionality of T cells and their progenitors, dendritic cells, B cells, and NK cells. γδ T cells have recently attracted great interest as effector cells for cel...
Source: European Journal of Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Dieter Kabelitz Lea Cierna Claudia Juraske Michal Zarobkiewicz Wolfgang W Schamel Christian Peters Source Type: research
Empowering γδ T-cell functionality with vitamin C
Eur J Immunol. 2024 Apr 15:e2451028. doi: 10.1002/eji.202451028. Online ahead of print.ABSTRACTVitamin C (ascorbic acid) is a potent antioxidant and a cofactor for various enzymes including histone demethylases and methylcytosine dioxygenases. Vitamin C also exerts direct cytotoxicity toward selected tumor cells including colorectal carcinoma. Moreover, vitamin C has been shown to impact immune cell differentiation at various levels including maturation and/or functionality of T cells and their progenitors, dendritic cells, B cells, and NK cells. γδ T cells have recently attracted great interest as effector cells for cel...
Source: European Journal of Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Dieter Kabelitz Lea Cierna Claudia Juraske Michal Zarobkiewicz Wolfgang W Schamel Christian Peters Source Type: research
Impressum
Eur J Immunol. 2024 Apr;54(4):e2470043. doi: 10.1002/eji.202470043.NO ABSTRACTPMID:38609690 | DOI:10.1002/eji.202470043 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 12, 2024 Category: Allergy & Immunology Source Type: research
Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation
Eur J Immunol. 2024 Apr 9:e2250342. doi: 10.1002/eji.202250342. Online ahead of print.ABSTRACTNatural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and nutrients. Vitamin A is an essential micronutrient that plays an indispensable role in embryogenesis and development, but was also reported to regulate immune responses. However, the role of vitamin A in regulating NK cell functions remains poorly understood. Here, we show that th...
Source: European Journal of Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Mingeum Jeong Francesco Cortopassi Jia-Xiang See Carolina De La Torre Adelheid Cerwenka Ana Stojanovic Source Type: research
