Predominance of M2 macrophages in organized thrombi in chronic thromboembolic pulmonary hypertension patients
Eur J Immunol. 2024 Apr 9:e2350670. doi: 10.1002/eji.202350670. Online ahead of print.ABSTRACTChronic thromboembolic pulmonary hypertension (CTEPH) is a debilitating disease characterized by thrombotic occlusion of pulmonary arteries and vasculopathy, leading to increased pulmonary vascular resistance and progressive right-sided heart failure. Thrombotic lesions in CTEPH contain CD68+ macrophages, and increasing evidence supports their role in disease pathogenesis. Macrophages are classically divided into pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages, which are involved in wound healing and tissue re...
Source: European Journal of Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Thomas Koudstaal Thierry van den Bosch Ingrid Bergen Karishma Lila Paul Bresser Harm Jan Bogaard Karin Boomars Rudi Hendriks Jan von der Th üsen Source Type: research
Diversification of the VH3-53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS-CoV-2 virus variants
Eur J Immunol. 2024 Apr 9:e2451056. doi: 10.1002/eji.202451056. Online ahead of print.ABSTRACTCOVID-19 induces re-circulating long-lived memory B cells (MBC) that, upon re-encounter with the pathogen, are induced to mount immunoglobulin responses. During convalescence, antibodies are subjected to affinity maturation, which enhances the antibody binding strength and generates new specificities that neutralize virus variants. Here, we performed a single-cell RNA sequencing analysis of spike-specific B cells from a SARS-CoV-2 convalescent subject. After COVID-19 vaccination, matured infection-induced MBC underwent recall and ...
Source: European Journal of Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Matthias Bruhn Maureen Obara Abdus Salam Bibiana Costa Annett Ziegler Inken Waltl Andreas Pavlou Markus Hoffmann Theresa Graalmann Stefan P öhlmann Axel Schambach Ulrich Kalinke Source Type: research
Immune quorum sensing dictates IFN-I response dynamics in human plasmacytoid dendritic cells
Eur J Immunol. 2024 Apr 8:e2350955. doi: 10.1002/eji.202350955. Online ahead of print.ABSTRACTType I interferons (IFN-Is) are key in fighting viral infections, but also serve major roles beyond antiviral immunity. Crucial is the tight regulation of IFN-I responses, while excessive levels are harmful to the cells. In essence, immune responses are generated by single cells making their own decisions, which are based on the signals they perceive. Additionally, immune cells must anticipate the future state of their environment, thereby weighing the costs and benefits of each possible outcome, in the presence of other potential...
Source: European Journal of Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Laura C Van Eyndhoven Cherise C Vreezen Bart M Tiemeijer Jurjen Tel Source Type: research
Immune quorum sensing dictates IFN-I response dynamics in human plasmacytoid dendritic cells
Eur J Immunol. 2024 Apr 8:e2350955. doi: 10.1002/eji.202350955. Online ahead of print.ABSTRACTType I interferons (IFN-Is) are key in fighting viral infections, but also serve major roles beyond antiviral immunity. Crucial is the tight regulation of IFN-I responses, while excessive levels are harmful to the cells. In essence, immune responses are generated by single cells making their own decisions, which are based on the signals they perceive. Additionally, immune cells must anticipate the future state of their environment, thereby weighing the costs and benefits of each possible outcome, in the presence of other potential...
Source: European Journal of Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Laura C Van Eyndhoven Cherise C Vreezen Bart M Tiemeijer Jurjen Tel Source Type: research
The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses
Eur J Immunol. 2024 Apr 5:e2350643. doi: 10.1002/eji.202350643. Online ahead of print.ABSTRACTWe implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.PMID:38581085 | DOI:10.1002/eji.202350643 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Susel Loli Quinteros Nathaniel W Snyder Adam Chatoff Fiona Ryan Bronwyn O'Brien Sheila Donnelly Source Type: research
Tumor-associated macrophages impair NK cell IFN- γ production and contribute to tumor progression in clear cell renal cell carcinoma
Eur J Immunol. 2024 Apr 6:e2350878. doi: 10.1002/eji.202350878. Online ahead of print.ABSTRACTTumor-associated macrophages (TAM) are abundant in several tumor types and usually correlate with poor prognosis. Previously, we demonstrated that anti-inflammatory macrophages (M2) inhibit NK cell effector functions. Here, we explored the impact of TAM on NK cells in the context of clear-cell renal cell carcinoma (ccRCC). Bioinformatics analysis revealed that an exhausted NK cell signature strongly correlated with an M2 signature. Analysis of TAM from human ccRCC samples confirmed that they exhibited an M2-skewed phenotype and in...
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Sol Yanel N úñez Aldana Trotta Mar ía Victoria Regge Mar ía Sofía Amarilla Florencia Secchiari Jessica Mariel Sierra Mar ía Cecilia Santilli Mariana Gantov Agust ín Rovegno Nicol ás Richards Carlos Ameri Hernando R íos Pita Luis Rico Mauro Mieggi Source Type: research
The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses
Eur J Immunol. 2024 Apr 5:e2350643. doi: 10.1002/eji.202350643. Online ahead of print.ABSTRACTWe implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.PMID:38581085 | DOI:10.1002/eji.202350643 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Susel Loli Quinteros Nathaniel W Snyder Adam Chatoff Fiona Ryan Bronwyn O'Brien Sheila Donnelly Source Type: research
Tumor-associated macrophages impair NK cell IFN- γ production and contribute to tumor progression in clear cell renal cell carcinoma
Eur J Immunol. 2024 Apr 6:e2350878. doi: 10.1002/eji.202350878. Online ahead of print.ABSTRACTTumor-associated macrophages (TAM) are abundant in several tumor types and usually correlate with poor prognosis. Previously, we demonstrated that anti-inflammatory macrophages (M2) inhibit NK cell effector functions. Here, we explored the impact of TAM on NK cells in the context of clear-cell renal cell carcinoma (ccRCC). Bioinformatics analysis revealed that an exhausted NK cell signature strongly correlated with an M2 signature. Analysis of TAM from human ccRCC samples confirmed that they exhibited an M2-skewed phenotype and in...
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Sol Yanel N úñez Aldana Trotta Mar ía Victoria Regge Mar ía Sofía Amarilla Florencia Secchiari Jessica Mariel Sierra Mar ía Cecilia Santilli Mariana Gantov Agust ín Rovegno Nicol ás Richards Carlos Ameri Hernando R íos Pita Luis Rico Mauro Mieggi Source Type: research
The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease
Eur J Immunol. 2024 Apr 4:e2350903. doi: 10.1002/eji.202350903. Online ahead of print.ABSTRACTWe induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.PMID:38576111 | DOI:10.1...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Anne Garreau Pauline Santa Maxime Dubois Damien Brisou Émeline Levionnois Pa ôline Laurent Amandine Ferriere Ana ïs Roubertie S éverine Loizon Doroth ée Duluc Patrick Blanco C écile Contin-Bordes Marie-Elise Truchetet Vanja Sisirak Source Type: research
Colony morphotype governs innate and adaptive pulmonary immune responses to Mycobacterium abscessus infection in C3HeB/FeJ mice
In this study, immunological outcomes of M. abscessus infection with S and R morphotypes were examined in an immune-competent C3HeB/FeJ murine model. R M. abscessus infection was associated with the rapid production of inflammatory chemokines and recruitment of activated, MHC-II+ Ly6C+ macrophages to lungs and mediastinal LN (mLN). While both S and R M. abscessus increased T helper 1 (Th1) phenotype T cells in the lung, this was markedly delayed in mice infected with S M. abscessus. However, histopathological involvement and bacterial clearance were similar regardless of colony morphotype. These results demonstrate the imp...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Kia C Ferrell Erica L Stewart Claudio Counoupas James A Triccas Source Type: research
The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease
Eur J Immunol. 2024 Apr 4:e2350903. doi: 10.1002/eji.202350903. Online ahead of print.ABSTRACTWe induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.PMID:38576111 | DOI:10.1...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Anne Garreau Pauline Santa Maxime Dubois Damien Brisou Émeline Levionnois Pa ôline Laurent Amandine Ferriere Ana ïs Roubertie S éverine Loizon Doroth ée Duluc Patrick Blanco C écile Contin-Bordes Marie-Elise Truchetet Vanja Sisirak Source Type: research
Colony morphotype governs innate and adaptive pulmonary immune responses to Mycobacterium abscessus infection in C3HeB/FeJ mice
In this study, immunological outcomes of M. abscessus infection with S and R morphotypes were examined in an immune-competent C3HeB/FeJ murine model. R M. abscessus infection was associated with the rapid production of inflammatory chemokines and recruitment of activated, MHC-II+ Ly6C+ macrophages to lungs and mediastinal LN (mLN). While both S and R M. abscessus increased T helper 1 (Th1) phenotype T cells in the lung, this was markedly delayed in mice infected with S M. abscessus. However, histopathological involvement and bacterial clearance were similar regardless of colony morphotype. These results demonstrate the imp...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Kia C Ferrell Erica L Stewart Claudio Counoupas James A Triccas Source Type: research
The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease
Eur J Immunol. 2024 Apr 4:e2350903. doi: 10.1002/eji.202350903. Online ahead of print.ABSTRACTWe induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.PMID:38576111 | DOI:10.1...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Anne Garreau Pauline Santa Maxime Dubois Damien Brisou Émeline Levionnois Pa ôline Laurent Amandine Ferriere Ana ïs Roubertie S éverine Loizon Doroth ée Duluc Patrick Blanco C écile Contin-Bordes Marie-Elise Truchetet Vanja Sisirak Source Type: research
Colony morphotype governs innate and adaptive pulmonary immune responses to Mycobacterium abscessus infection in C3HeB/FeJ mice
In this study, immunological outcomes of M. abscessus infection with S and R morphotypes were examined in an immune-competent C3HeB/FeJ murine model. R M. abscessus infection was associated with the rapid production of inflammatory chemokines and recruitment of activated, MHC-II+ Ly6C+ macrophages to lungs and mediastinal LN (mLN). While both S and R M. abscessus increased T helper 1 (Th1) phenotype T cells in the lung, this was markedly delayed in mice infected with S M. abscessus. However, histopathological involvement and bacterial clearance were similar regardless of colony morphotype. These results demonstrate the imp...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Kia C Ferrell Erica L Stewart Claudio Counoupas James A Triccas Source Type: research
YF17D-based vaccines - standing on the shoulders of a giant
Eur J Immunol. 2024 Apr 3:e2250133. doi: 10.1002/eji.202250133. Online ahead of print.ABSTRACTLive-attenuated yellow fever vaccine (YF17D) was developed in the 1930s as the first ever empirically derived human vaccine. Ninety years later, it is still a benchmark for vaccines made today. YF17D triggers a particularly broad and polyfunctional response engaging multiple arms of innate, humoral and cellular immunity. This unique immunogenicity translates into an extraordinary vaccine efficacy and outstanding longevity of protection, possibly by single-dose immunization. More recently, progress in molecular virology and synthet...
Source: European Journal of Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Lorena Sanchez-Felipe Yeranddy A Alpizar Ji Ma Lotte Coelmont Kai Dallmeier Source Type: research
