Innate lymphoid cells: New players in osteoimmunology
Eur J Immunol. 2024 Jan 17:e2350381. doi: 10.1002/eji.202350381. Online ahead of print.ABSTRACTInnate lymphoid cells (ILCs) are the most recently identified immune cell types existing in lymphoid and nonlymphoid organs. Albeit they lack the expression of antigen receptors, ILCs play vital roles in innate immune responses by producing multiple effector cytokines. The ILC family includes conventional natural killer cells and cytokine-producing ILCs, which are divided into group 1, group 2, and group 3 ILCs based on their effector cytokines and developmental requirements. Emerging evidence has indicated that ILCs are essentia...
Source: European Journal of Immunology - January 18, 2024 Category: Allergy & Immunology Authors: Zuoxing Wu Xixi Lin Guixin Yuan Na Li Ren Xu Source Type: research
Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice
This study highlights the importance of the TRAPPC in T-cell biology.PMID:38234007 | DOI:10.1002/eji.202350836 (Source: European Journal of Immunology)
Source: European Journal of Immunology - January 18, 2024 Category: Allergy & Immunology Authors: Zhaoqi Zhang Chenxu Zhao Lingyun Sun Chen Cheng Qianchuan Tian Changhong Wu Yanan Xu Xue Dong Baojun Zhang Lianfeng Zhang Yong Zhao Source Type: research
Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells
Eur J Immunol. 2024 Jan 17:e2350743. doi: 10.1002/eji.202350743. Online ahead of print.ABSTRACTCandida albicans causes opportunistic infections ranging from mucosal mycoses to life-threatening systemic infections in immunocompromised patients. During C. albicans infection, leukotrienes and prostaglandins are formed from arachidonic acid by 5-lipoxygenase (5-LOX) and cyclooxygenases, respectively to amplify inflammatory conditions, but also to initiate macrophage infiltration to achieve tissue homeostasis. Since less is known about the cellular mechanisms triggering such lipid mediator biosynthesis, we investigated the eico...
Source: European Journal of Immunology - January 17, 2024 Category: Allergy & Immunology Authors: Jana Schimanski Mark S Gresnigt Elena Brunner Oliver Werz Bernhard Hube Ulrike Garscha Source Type: research
Gingival fibroblast activation by Porphyromonas gingivalis is driven by TLR2 and is independent of the LPS-TLR4 axis
Eur J Immunol. 2024 Jan 8:e2350776. doi: 10.1002/eji.202350776. Online ahead of print.ABSTRACTGingival fibroblasts (GFs) are abundant structural cells of the periodontium that contribute to the host's innate immunity by producing cytokines and chemokines in response to oral pathogens, such as Porphyromonas gingivalis. Isolated lipopolysaccharide (Pg-LPS) is commonly used to study GF responses to P. gingivalis; however, this approach produced conflicting observations regarding its proinflammatory potential and the engagement of specific Toll-like receptors (TLRs). In this work, we demonstrate that commercially available Pg-...
Source: European Journal of Immunology - January 8, 2024 Category: Allergy & Immunology Authors: Aureliusz Schuster Elwira Nieboga Malgorzata Kantorowicz Weronika Lipska Tomasz Kaczmarzyk Jan Potempa Aleksander M Grabiec Source Type: research
Gingival fibroblast activation by Porphyromonas gingivalis is driven by TLR2 and is independent of the LPS-TLR4 axis
Eur J Immunol. 2024 Jan 8:e2350776. doi: 10.1002/eji.202350776. Online ahead of print.ABSTRACTGingival fibroblasts (GFs) are abundant structural cells of the periodontium that contribute to the host's innate immunity by producing cytokines and chemokines in response to oral pathogens, such as Porphyromonas gingivalis. Isolated lipopolysaccharide (Pg-LPS) is commonly used to study GF responses to P. gingivalis; however, this approach produced conflicting observations regarding its proinflammatory potential and the engagement of specific Toll-like receptors (TLRs). In this work, we demonstrate that commercially available Pg-...
Source: European Journal of Immunology - January 8, 2024 Category: Allergy & Immunology Authors: Aureliusz Schuster Elwira Nieboga Malgorzata Kantorowicz Weronika Lipska Tomasz Kaczmarzyk Jan Potempa Aleksander M Grabiec Source Type: research
Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis
Eur J Immunol. 2023 Dec 31:e2350666. doi: 10.1002/eji.202350666. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) can cause a latent infection that sometimes progresses to clinically active tuberculosis (TB). Type I interferons (IFN-I) have been implicated in initiating the progression from latency to active TB, in part because IFN-I stimulated genes are the earliest genes to be upregulated in patients as they advance to active TB. Plasmacytoid dendritic cells (pDCs) are major producers of IFN-I during viral infections and in response to autoimmune-induced neutrophil extracellular traps. pDCs have also been s...
Source: European Journal of Immunology - December 31, 2023 Category: Allergy & Immunology Authors: Angela M Lee Pa ôline Laurent Carl F Nathan Franck J Barrat Source Type: research
Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis
Eur J Immunol. 2023 Dec 31:e2350666. doi: 10.1002/eji.202350666. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) can cause a latent infection that sometimes progresses to clinically active tuberculosis (TB). Type I interferons (IFN-I) have been implicated in initiating the progression from latency to active TB, in part because IFN-I stimulated genes are the earliest genes to be upregulated in patients as they advance to active TB. Plasmacytoid dendritic cells (pDCs) are major producers of IFN-I during viral infections and in response to autoimmune-induced neutrophil extracellular traps. pDCs have also been s...
Source: European Journal of Immunology - December 31, 2023 Category: Allergy & Immunology Authors: Angela M Lee Pa ôline Laurent Carl F Nathan Franck J Barrat Source Type: research
Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis
Eur J Immunol. 2023 Dec 31:e2350666. doi: 10.1002/eji.202350666. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) can cause a latent infection that sometimes progresses to clinically active tuberculosis (TB). Type I interferons (IFN-I) have been implicated in initiating the progression from latency to active TB, in part because IFN-I stimulated genes are the earliest genes to be upregulated in patients as they advance to active TB. Plasmacytoid dendritic cells (pDCs) are major producers of IFN-I during viral infections and in response to autoimmune-induced neutrophil extracellular traps. pDCs have also been s...
Source: European Journal of Immunology - December 31, 2023 Category: Allergy & Immunology Authors: Angela M Lee Pa ôline Laurent Carl F Nathan Franck J Barrat Source Type: research
Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis
Eur J Immunol. 2023 Dec 31:e2350666. doi: 10.1002/eji.202350666. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) can cause a latent infection that sometimes progresses to clinically active tuberculosis (TB). Type I interferons (IFN-I) have been implicated in initiating the progression from latency to active TB, in part because IFN-I stimulated genes are the earliest genes to be upregulated in patients as they advance to active TB. Plasmacytoid dendritic cells (pDCs) are major producers of IFN-I during viral infections and in response to autoimmune-induced neutrophil extracellular traps. pDCs have also been s...
Source: European Journal of Immunology - December 31, 2023 Category: Allergy & Immunology Authors: Angela M Lee Pa ôline Laurent Carl F Nathan Franck J Barrat Source Type: research
Neutrophil-plasmacytoid dendritic cell interaction leads to production of type I IFN in response to Mycobacterium tuberculosis
Eur J Immunol. 2023 Dec 31:e2350666. doi: 10.1002/eji.202350666. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) can cause a latent infection that sometimes progresses to clinically active tuberculosis (TB). Type I interferons (IFN-I) have been implicated in initiating the progression from latency to active TB, in part because IFN-I stimulated genes are the earliest genes to be upregulated in patients as they advance to active TB. Plasmacytoid dendritic cells (pDCs) are major producers of IFN-I during viral infections and in response to autoimmune-induced neutrophil extracellular traps. pDCs have also been s...
Source: European Journal of Immunology - December 31, 2023 Category: Allergy & Immunology Authors: Angela M Lee Pa ôline Laurent Carl F Nathan Franck J Barrat Source Type: research
Current advances in bacteria-based cancer immunotherapy
Eur J Immunol. 2023 Dec 17:e2350778. doi: 10.1002/eji.202350778. Online ahead of print.ABSTRACTAs the understanding of the tumor microenvironment has deepened, immunotherapy has become a promising strategy for cancer treatment. In contrast to traditional therapies, immunotherapy is more precise and induces fewer adverse effects. In this field, some bacteria have attracted increased attention because of their natural ability to preferentially colonize and proliferate inside tumor sites and exert antitumor effects. Moreover, bacterial components may activate innate and adaptive immunity to resist tumor progression. However, ...
Source: European Journal of Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Caijuan Guo Jinyan Liu Yi Zhang Source Type: research
Current advances in bacteria-based cancer immunotherapy
Eur J Immunol. 2023 Dec 17:e2350778. doi: 10.1002/eji.202350778. Online ahead of print.ABSTRACTAs the understanding of the tumor microenvironment has deepened, immunotherapy has become a promising strategy for cancer treatment. In contrast to traditional therapies, immunotherapy is more precise and induces fewer adverse effects. In this field, some bacteria have attracted increased attention because of their natural ability to preferentially colonize and proliferate inside tumor sites and exert antitumor effects. Moreover, bacterial components may activate innate and adaptive immunity to resist tumor progression. However, ...
Source: European Journal of Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Caijuan Guo Jinyan Liu Yi Zhang Source Type: research
Current advances in bacteria-based cancer immunotherapy
Eur J Immunol. 2023 Dec 17:e2350778. doi: 10.1002/eji.202350778. Online ahead of print.ABSTRACTAs the understanding of the tumor microenvironment has deepened, immunotherapy has become a promising strategy for cancer treatment. In contrast to traditional therapies, immunotherapy is more precise and induces fewer adverse effects. In this field, some bacteria have attracted increased attention because of their natural ability to preferentially colonize and proliferate inside tumor sites and exert antitumor effects. Moreover, bacterial components may activate innate and adaptive immunity to resist tumor progression. However, ...
Source: European Journal of Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Caijuan Guo Jinyan Liu Yi Zhang Source Type: research
Current advances in bacteria-based cancer immunotherapy
Eur J Immunol. 2023 Dec 17:e2350778. doi: 10.1002/eji.202350778. Online ahead of print.ABSTRACTAs the understanding of the tumor microenvironment has deepened, immunotherapy has become a promising strategy for cancer treatment. In contrast to traditional therapies, immunotherapy is more precise and induces fewer adverse effects. In this field, some bacteria have attracted increased attention because of their natural ability to preferentially colonize and proliferate inside tumor sites and exert antitumor effects. Moreover, bacterial components may activate innate and adaptive immunity to resist tumor progression. However, ...
Source: European Journal of Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Caijuan Guo Jinyan Liu Yi Zhang Source Type: research
Current advances in bacteria-based cancer immunotherapy
Eur J Immunol. 2023 Dec 17:e2350778. doi: 10.1002/eji.202350778. Online ahead of print.ABSTRACTAs the understanding of the tumor microenvironment has deepened, immunotherapy has become a promising strategy for cancer treatment. In contrast to traditional therapies, immunotherapy is more precise and induces fewer adverse effects. In this field, some bacteria have attracted increased attention because of their natural ability to preferentially colonize and proliferate inside tumor sites and exert antitumor effects. Moreover, bacterial components may activate innate and adaptive immunity to resist tumor progression. However, ...
Source: European Journal of Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Caijuan Guo Jinyan Liu Yi Zhang Source Type: research
