The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses
Eur J Immunol. 2024 Apr 5:e2350643. doi: 10.1002/eji.202350643. Online ahead of print.ABSTRACTWe implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.PMID:38581085 | DOI:10.1002/eji.202350643 (Source: European Journal of Immunology)
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Susel Loli Quinteros Nathaniel W Snyder Adam Chatoff Fiona Ryan Bronwyn O'Brien Sheila Donnelly Source Type: research
Tumor-associated macrophages impair NK cell IFN- γ production and contribute to tumor progression in clear cell renal cell carcinoma
Eur J Immunol. 2024 Apr 6:e2350878. doi: 10.1002/eji.202350878. Online ahead of print.ABSTRACTTumor-associated macrophages (TAM) are abundant in several tumor types and usually correlate with poor prognosis. Previously, we demonstrated that anti-inflammatory macrophages (M2) inhibit NK cell effector functions. Here, we explored the impact of TAM on NK cells in the context of clear-cell renal cell carcinoma (ccRCC). Bioinformatics analysis revealed that an exhausted NK cell signature strongly correlated with an M2 signature. Analysis of TAM from human ccRCC samples confirmed that they exhibited an M2-skewed phenotype and in...
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Sol Yanel N úñez Aldana Trotta Mar ía Victoria Regge Mar ía Sofía Amarilla Florencia Secchiari Jessica Mariel Sierra Mar ía Cecilia Santilli Mariana Gantov Agust ín Rovegno Nicol ás Richards Carlos Ameri Hernando R íos Pita Luis Rico Mauro Mieggi Source Type: research
The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease
Eur J Immunol. 2024 Apr 4:e2350903. doi: 10.1002/eji.202350903. Online ahead of print.ABSTRACTWe induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.PMID:38576111 | DOI:10.1...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Anne Garreau Pauline Santa Maxime Dubois Damien Brisou Émeline Levionnois Pa ôline Laurent Amandine Ferriere Ana ïs Roubertie S éverine Loizon Doroth ée Duluc Patrick Blanco C écile Contin-Bordes Marie-Elise Truchetet Vanja Sisirak Source Type: research
Colony morphotype governs innate and adaptive pulmonary immune responses to Mycobacterium abscessus infection in C3HeB/FeJ mice
In this study, immunological outcomes of M. abscessus infection with S and R morphotypes were examined in an immune-competent C3HeB/FeJ murine model. R M. abscessus infection was associated with the rapid production of inflammatory chemokines and recruitment of activated, MHC-II+ Ly6C+ macrophages to lungs and mediastinal LN (mLN). While both S and R M. abscessus increased T helper 1 (Th1) phenotype T cells in the lung, this was markedly delayed in mice infected with S M. abscessus. However, histopathological involvement and bacterial clearance were similar regardless of colony morphotype. These results demonstrate the imp...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Kia C Ferrell Erica L Stewart Claudio Counoupas James A Triccas Source Type: research
The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease
Eur J Immunol. 2024 Apr 4:e2350903. doi: 10.1002/eji.202350903. Online ahead of print.ABSTRACTWe induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.PMID:38576111 | DOI:10.1...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Anne Garreau Pauline Santa Maxime Dubois Damien Brisou Émeline Levionnois Pa ôline Laurent Amandine Ferriere Ana ïs Roubertie S éverine Loizon Doroth ée Duluc Patrick Blanco C écile Contin-Bordes Marie-Elise Truchetet Vanja Sisirak Source Type: research
Colony morphotype governs innate and adaptive pulmonary immune responses to Mycobacterium abscessus infection in C3HeB/FeJ mice
In this study, immunological outcomes of M. abscessus infection with S and R morphotypes were examined in an immune-competent C3HeB/FeJ murine model. R M. abscessus infection was associated with the rapid production of inflammatory chemokines and recruitment of activated, MHC-II+ Ly6C+ macrophages to lungs and mediastinal LN (mLN). While both S and R M. abscessus increased T helper 1 (Th1) phenotype T cells in the lung, this was markedly delayed in mice infected with S M. abscessus. However, histopathological involvement and bacterial clearance were similar regardless of colony morphotype. These results demonstrate the imp...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Kia C Ferrell Erica L Stewart Claudio Counoupas James A Triccas Source Type: research
The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease
Eur J Immunol. 2024 Apr 4:e2350903. doi: 10.1002/eji.202350903. Online ahead of print.ABSTRACTWe induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.PMID:38576111 | DOI:10.1...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Anne Garreau Pauline Santa Maxime Dubois Damien Brisou Émeline Levionnois Pa ôline Laurent Amandine Ferriere Ana ïs Roubertie S éverine Loizon Doroth ée Duluc Patrick Blanco C écile Contin-Bordes Marie-Elise Truchetet Vanja Sisirak Source Type: research
Colony morphotype governs innate and adaptive pulmonary immune responses to Mycobacterium abscessus infection in C3HeB/FeJ mice
In this study, immunological outcomes of M. abscessus infection with S and R morphotypes were examined in an immune-competent C3HeB/FeJ murine model. R M. abscessus infection was associated with the rapid production of inflammatory chemokines and recruitment of activated, MHC-II+ Ly6C+ macrophages to lungs and mediastinal LN (mLN). While both S and R M. abscessus increased T helper 1 (Th1) phenotype T cells in the lung, this was markedly delayed in mice infected with S M. abscessus. However, histopathological involvement and bacterial clearance were similar regardless of colony morphotype. These results demonstrate the imp...
Source: European Journal of Immunology - April 5, 2024 Category: Allergy & Immunology Authors: Kia C Ferrell Erica L Stewart Claudio Counoupas James A Triccas Source Type: research
YF17D-based vaccines - standing on the shoulders of a giant
Eur J Immunol. 2024 Apr 3:e2250133. doi: 10.1002/eji.202250133. Online ahead of print.ABSTRACTLive-attenuated yellow fever vaccine (YF17D) was developed in the 1930s as the first ever empirically derived human vaccine. Ninety years later, it is still a benchmark for vaccines made today. YF17D triggers a particularly broad and polyfunctional response engaging multiple arms of innate, humoral and cellular immunity. This unique immunogenicity translates into an extraordinary vaccine efficacy and outstanding longevity of protection, possibly by single-dose immunization. More recently, progress in molecular virology and synthet...
Source: European Journal of Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Lorena Sanchez-Felipe Yeranddy A Alpizar Ji Ma Lotte Coelmont Kai Dallmeier Source Type: research
Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis
Eur J Immunol. 2024 Apr 2:e2350761. doi: 10.1002/eji.202350761. Online ahead of print.ABSTRACTIn multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), early pathological features include immune cell infiltration into the central nervous system (CNS) and blood-brain barrier (BBB) disruption. We investigated the role of junctional adhesion molecule-A (JAM-A), a tight junction protein, in active EAE (aEAE) pathogenesis. Our study confirms JAM-A expression at the blood-brain barrier and its luminal redistribution during aEAE. JAM-A deficient (JAM-A-/-) C57BL/6J mice exhibited milder aEAE, un...
Source: European Journal of Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Kristina Berve Julia Michel Silvia Tietz Claudia Blatti Daniela Ivan Gaby Enzmann Ruth Lyck Urban Deutsch Giuseppe Locatelli Britta Engelhardt Source Type: research
Junctional adhesion molecule-A deficient mice are protected from severe experimental autoimmune encephalomyelitis
Eur J Immunol. 2024 Apr 2:e2350761. doi: 10.1002/eji.202350761. Online ahead of print.ABSTRACTIn multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), early pathological features include immune cell infiltration into the central nervous system (CNS) and blood-brain barrier (BBB) disruption. We investigated the role of junctional adhesion molecule-A (JAM-A), a tight junction protein, in active EAE (aEAE) pathogenesis. Our study confirms JAM-A expression at the blood-brain barrier and its luminal redistribution during aEAE. JAM-A deficient (JAM-A-/-) C57BL/6J mice exhibited milder aEAE, un...
Source: European Journal of Immunology - April 3, 2024 Category: Allergy & Immunology Authors: Kristina Berve Julia Michel Silvia Tietz Claudia Blatti Daniela Ivan Gaby Enzmann Ruth Lyck Urban Deutsch Giuseppe Locatelli Britta Engelhardt Source Type: research
Intranasal administration of unadjuvanted SARS-CoV-2 spike antigen boosts antigen-specific immune responses induced by parenteral protein subunit vaccine prime in mice and hamsters
Eur J Immunol. 2024 Apr 1:e2350620. doi: 10.1002/eji.202350620. Online ahead of print.ABSTRACTWith the continued transmission of SARS-CoV-2 across widely vaccinated populations, it remains important to develop new vaccines and vaccination strategies capable of providing protective immunity and limiting the spread of disease. Heterologous prime-boost vaccination based on the selection of different vaccine formulations and administration routes for priming and booster doses presents a promising strategy for inducing broader immune responses in key systemic and respiratory mucosal compartments. Intranasal vaccination can indu...
Source: European Journal of Immunology - April 2, 2024 Category: Allergy & Immunology Authors: Gerard Agbayani Bassel Akache Tyler M Renner Anh Tran Matthew Stuible Renu Dudani Blair A Harrison Diana Duque Jegarubee Bavananthasivam Lise Deschatelets Usha D Hemraz Sophie R égnier Yves Durocher Michael J McCluskie Source Type: research
Intranasal administration of unadjuvanted SARS-CoV-2 spike antigen boosts antigen-specific immune responses induced by parenteral protein subunit vaccine prime in mice and hamsters
Eur J Immunol. 2024 Apr 1:e2350620. doi: 10.1002/eji.202350620. Online ahead of print.ABSTRACTWith the continued transmission of SARS-CoV-2 across widely vaccinated populations, it remains important to develop new vaccines and vaccination strategies capable of providing protective immunity and limiting the spread of disease. Heterologous prime-boost vaccination based on the selection of different vaccine formulations and administration routes for priming and booster doses presents a promising strategy for inducing broader immune responses in key systemic and respiratory mucosal compartments. Intranasal vaccination can indu...
Source: European Journal of Immunology - April 2, 2024 Category: Allergy & Immunology Authors: Gerard Agbayani Bassel Akache Tyler M Renner Anh Tran Matthew Stuible Renu Dudani Blair A Harrison Diana Duque Jegarubee Bavananthasivam Lise Deschatelets Usha D Hemraz Sophie R égnier Yves Durocher Michael J McCluskie Source Type: research
Epithelial-immune cell crosstalk for intestinal barrier homeostasis
Eur J Immunol. 2024 Mar 31:e2350631. doi: 10.1002/eji.202350631. Online ahead of print.ABSTRACTThe intestinal barrier is mainly formed by a monolayer of epithelial cells, which forms a physical barrier to protect the gut tissues from external insults and provides a microenvironment for commensal bacteria to colonize while ensuring immune tolerance. Moreover, various immune cells are known to significantly contribute to intestinal barrier function by either directly interacting with epithelial cells or by producing immune mediators. Fulfilling this function of the gut barrier for mucosal homeostasis requires not only the in...
Source: European Journal of Immunology - March 31, 2024 Category: Allergy & Immunology Authors: Yikun Yao Wanjing Shang Lingyu Bao Zhaoyi Peng Chuan Wu Source Type: research
Polymorphism in F pocket affects peptide selection and stability of type 1 diabetes-associated HLA-B39 allotypes
Eur J Immunol. 2024 Mar 29:e2350683. doi: 10.1002/eji.202350683. Online ahead of print.ABSTRACTHLA-B*39:06, HLA-B*39:01, and HLA-B*38:01 are closely related HLA allotypes differentially associated with type 1 diabetes (T1D) risk and progression. B*39:06 is highly predisposing, while B*39:01 and B*38:01 are weakly predisposing and protective allotypes, respectively. Here, we aimed to decipher molecular mechanisms underlying the differential association of these allotypes with T1D pathogenesis. We addressed peptide binding and conformational stability of HLA-B allotypes using computational and experimental approaches. Comput...
Source: European Journal of Immunology - March 29, 2024 Category: Allergy & Immunology Authors: A W Peshala Amarajeewa Aslihan Özcan Alveena Mukhtiar Xu Ren Qianyu Wang Pemra Ozbek Malgorzata A Garstka Onur Ser çinoğlu Source Type: research
