The deficiency of DNASE1L3 does not affect systemic sclerosis pathogenesis in two inducible murine models of the disease
Eur J Immunol. 2024 Apr 4:e2350903. doi: 10.1002/eji.202350903. Online ahead of print.ABSTRACTWe induced systemic sclerosis (SSc)-like disease in both wild-type and Dnase1l3-deficient mice using two distinct approaches involving bleomycin and hypochlorous acid injections. Our observations revealed that the deficiency in DNASE1L3 did not affect tissue fibrosis or inflammation caused by these treatments. Despite the association of single nucleotide polymorphisms in humans with SSc pathogenesis, our study demonstrates that DNASE1L3 is dispensable in two inducible murine models of SSc-like pathogenesis.PMID:38576111 | DOI:10.1002/eji.202350903
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Anne Garreau Pauline Santa Maxime Dubois Damien Brisou Émeline Levionnois Pa ôline Laurent Amandine Ferriere Ana ïs Roubertie S éverine Loizon Doroth ée Duluc Patrick Blanco C écile Contin-Bordes Marie-Elise Truchetet Vanja Sisirak Source Type: research