131I Induced In Vivo Proteolysis by Photoswitchable azoPROTAC Reinforces Internal Radiotherapy
For the first time, this study proves that131I can trigger the trans-cis photoisomerization of a reported azobenezen incorporating PROTACs (azoPROTAC). Both in vitro and in vivo experiments prove that co-administration of131I and azoPROTAC can not only effectively down-regulate the BRD4 protein, but also exhibit excellent tumor inhibition with BRD4 degradation enhanced radiotherapeutic and immunological effect. AbstractPhotopharmacology, incorporating photoswitches such as azobenezes into drugs, is an emerging therapeutic method to realize spatiotemporal control of pharmacological activity by light. However, most photoswit...
Source: Small - April 28, 2024 Category: Nanotechnology Authors: Huihui Liu,
Hehua Xiong,
Changjun Li,
Mengxia Xu,
Yuyang Yun,
Yiling Ruan,
Lijun Tang,
Tao Zhang,
Dan Su,
Xiaolian Sun Tags: Research Article Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
Collective good and individual choice: Perceptions on COVID-19 vaccine mandate among COVID-19 vaccinated individuals
CONCLUSION: Support for a COVID-19 vaccination mandate is controversial even among vaccinated people. Identifying and understanding cultural and contextual factors that underlie differences in attitudes and beliefs about COVID-19 vaccination mandates is essential to advance dialogue and inform educational health campaigns to increase COVID-19 vaccination rates.PMID:38679513 | DOI:10.1016/j.vaccine.2024.04.052 (Source: Vaccine)
Source: Vaccine - April 28, 2024 Category: Allergy & Immunology Authors: Kaivalya Gudooru Kimberly Nguyen Kathy Le Vyas Sarabu Meredith Hosek Anna Phan Michelle Garza Bertha E Flores Armida Flores Amelie Ramirez Luz M Garcini Source Type: research
Association between Covishield vaccine and menstrual disturbance. Findings from a cross-sectional study among participants of Zero TB cohort in India
CONCLUSION: Menstrual problems were reported by Covishield vaccinees, but they were minor and reversible within three months and do not constitute a ground for vaccine hesitancy. Studies designed to assess causal link taking care to avoid selection bias or confounding are needed.PMID:38679512 | DOI:10.1016/j.vaccine.2024.04.063 (Source: Vaccine)
Source: Vaccine - April 28, 2024 Category: Allergy & Immunology Authors: Kunchok Dorjee Tenzin Namdon Sonam Topgyal Ugen Gyatso Tenzin Tsundue Tashi Dolma Vipan Kumar Dekyi Lhadon Tenzin Yangkyi Tenzin Khachoe Sangyal Dorjee R C Sadoff David Peters Amita Gupta Zorba Paster Richard E Chaisson Dawa Phunkyi Tsetan D Sadutshang Source Type: research
Effect of exposure to disinfection by-products during swimming exercise on asthma-related immune responses
In this study, we investigated the influence of swimming exercise and DBPs on asthma. The decomposition products had little effect on the number of T cells in various immune organs. However, swimming exercise was found to increase the cell count in proportion to the exercise duration. Nevertheless, there were no significant changes in other immune cells and the secretion of asthma-related cytokines. These findings indicate that the effects of swimming pool DBPs on respiratory conditions during swimming exercise are either negligible or absent, and instead, the immunological benefits gained through consistent swimming exerc...
Source: Journal of Water and Health - April 28, 2024 Category: Environmental Health Authors: Bo-Ae Lee Source Type: research
PD-BAT: A novel approach of pooling basophil donors for expansion of commercial laboratory testing of Chronic Spontaneous Urticaria
In this study, we introduce an innovative approach where multiple potential basophil donors undergo rigorous BAT characterization alongside control samples. By selecting and pooling donors with optimal performance, we significantly enhance the inter-assay reproducibility of the indirect BAT test.PMID:38679364 | DOI:10.1016/j.jim.2024.113679 (Source: Journal of Immunological Methods)
Source: Journal of Immunological Methods - April 28, 2024 Category: Allergy & Immunology Authors: Saintedym Wills Jessica Chavez Ajay Grover Nathanael Beck Michele Romano Christina Bauer Michael Gerspach Michael Schneider Andre Valcour Source Type: research
Levels of Immunoglobulin E Sensitization Drive Symptom Thresholds in Allergic Rhinitis
CONCLUSION: With increasing number of sensitizations, AR patients experience an increased diversity of symptoms. Multimorbidity-related symptoms increase with sensitization rank, suggesting organ-specific thresholds.PMID:38679157 | DOI:10.1016/j.anai.2024.04.026 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 28, 2024 Category: Allergy & Immunology Authors: Maria V Dimou Paraskevi Xepapadaki John Lakoumentas Leonardos Mageiros Xenophon Aggelidis Maria Antonopoulou Petros Bakakos Sophia Βotskariova Konstantinos Chliveros Spyridon Chrysoulakis Dionysios Dimas Nikolaos Douladiris Mina Gaga Christos Grigoreas L Source Type: research
The Future of Therapeutic Options for Hereditary Angioedema
Ann Allergy Asthma Immunol. 2024 Apr 26:S1081-1206(24)00275-8. doi: 10.1016/j.anai.2024.04.029. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare, genetic condition causing unpredictable and severe episodes of angioedema that are debilitating and life-threatening. HAE can be classified into HAE due to C1INH deficiency (HAE-C1INH), or HAE with normal C1INH (HAE-nl-C1INH). HAE-C1INH is subcategorized as type I and II based upon deficient or dysfunctional circulating C1INH protein resulting from inherited or spontaneous mutations in the SERPING1 gene leading to uncontrolled Factor XII(FXII)/plasma kallikrein...
Source: Annals of Allergy, Asthma and Immunology - April 28, 2024 Category: Allergy & Immunology Authors: Tukisa D Smith Marc A Riedl Source Type: research
Tumor cells inhibit the activation of ILC2s through up-regulating PD-1 expression
Immunopharmacol Immunotoxicol. 2024 Apr 28:1-10. doi: 10.1080/08923973.2024.2347315. Online ahead of print.ABSTRACTUp-regulating programmed cell death ligand-1(PD-L1) expressed on tumor cells and tumor-infiltrating myeloid cells interacting with up-regulated programmed cell death-1 (PD-1) expressed on tumor-infiltrating lymphoid cells greatly hinder their tumor-inhibiting effect. It is necessary to explore the deep mechanism of this negative effect, so as to find the potential methods to improve the immunotherapy efficiency. Here, we found that the PD-1 expression in lung cancer-infiltrating type II innate lymphoid cells (...
Source: Immunopharmacology and Immunotoxicology - April 28, 2024 Category: Allergy & Immunology Authors: Chaoyun Yin Yani Pa Guangyu Li Qiang Chen Xizu Wang Xijun He Huangao Zhou Source Type: research
Potential biomarkers for immune monitoring after renal transplantation
Transpl Immunol. 2024 Apr 26:102046. doi: 10.1016/j.trim.2024.102046. Online ahead of print.ABSTRACTRenal transplantation represents the foremost efficacious approach for ameliorating end-stage renal disease. Despite the current state of advanced renal transplantation techniques and the established postoperative immunosuppression strategy, a subset of patients continues to experience immune rejection during both the early and late postoperative phases, ultimately leading to graft loss. Consequently, the identification of immunobiomarkers capable of predicting the onset of immune rejection becomes imperative in order to fac...
Source: Transplant Immunology - April 28, 2024 Category: Transplant Surgery Authors: Xiaoyu Xu Yi Chen Luyue Kong Xianduo Li Dongdong Chen Zhe Yang Jianning Wang Source Type: research
Predictive Value of Nasal Nitric Oxide for Diagnosing Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
CONCLUSION: Nasal NO has the potential as a noninvasive diagnostic measure and endotype tool for ECRS.PMID:38679754 | DOI:10.1177/19458924241251387 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 28, 2024 Category: ENT & OMF Authors: Do Hyun Kim Hyesoo Shin Gulnaz Stybayeva Se Hwan Hwang Source Type: research
Recent advances in IgG4-related autoimmune pancreatitis
Pathol Res Pract. 2024 Apr 26;257:155331. doi: 10.1016/j.prp.2024.155331. Online ahead of print.ABSTRACTThe incidence of IgG4-related autoimmune pancreatitis (IgG4-AIP) is high in Asia and other countries, and unnecessary treatment is often undertaken due to both missed diagnosis and misdiagnosis in clinical practice. Although IgG4-AIP has attracted increasing attention, the details of IgG4-AIP pathogenesis and systemic immune response, including its relationship to tumor pathogenesis, are still unclear. In recent years, research on serum immunological detection, pathological features, clinical manifestations, diagnosis an...
Source: Pathology, Research and Practice - April 28, 2024 Category: Pathology Authors: Xisheng Yang Haikun Zhou Weidong Wang Chunyu Yan Gang Ji Source Type: research
Characterization of the prognostic, diagnostic, and immunological roles of DSCC1 and its genomic alteration and instability in human cancers
In this study, we obtained data on physiological conditions, transcriptional expression, survival prognosis, genomic alteration, genomic instability, enriched pathways, immune infiltration, and immunotherapy from The Cancer Genome Atlas, The Genotype-Tissue Expression, cBioPortal, and other publicly available databases to systematically characterize the oncogenic and immunological roles of DSCC1 in 33 different cancers. We found that DSCC1 expression was upregulated at both mRNA and protein levels in various cancers. Additionally, DSCC1 expression was associated with higher tumor stage and grade in specific cancers. DSCC1 ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Hailong Liu Zhiwei Cui Rongli Wang Lijun Wang Lihui Wang Feiyan Cheng Rumeng Pan Xinyuan Yang Source Type: research
MAL, a potential immunotherapy target, is associated with poor prognosis in cancer patients
In conclusion, the pan-cancer study indicates that MAL with excellent prognostic value is a potential immunotherapy target in multiple cancers.PMID:38678596 | DOI:10.14715/cmb/2024.70.4.39 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Ruinian Zheng Biao Yao Yongkang Ye Ruijuan Luo Zhiming Wu Xiarong Hu Yinjiao Yuan Xuebing Pan Caixiang Liu Linxuan Huang Yongmei Luo Dan Yang NiYa Shang Yamin Tian Jun Jia Source Type: research
