The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients
In this study, we aimed to know whether the extensive inter and intra heterogeneity of TAMs contributes to the clinical outcomes and indications for immune checkpoint blockade (ICB) in CRC. We used single-cell RNA sequencing (scRNA-Seq) data from 60 CRC patients and charactrized TAMs based on anatomic locations, tumor regions, stages, grades, metastatic status, MSS/MSI classification and pseudotemporal differentiation status. We then defined a catalog of 21 gene modules that determine macrophage status, and identified 7 of them as relevant to clinical outcomes and 11 as indications for ICB therapy. On this basis, we constr...
Source: Immunobiology - April 26, 2024 Category: Allergy & Immunology Authors: Junhui Tang Liang Ming Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
Leishmania vaccine development: A comprehensive review
Cell Immunol. 2024 Apr 23;399-400:104826. doi: 10.1016/j.cellimm.2024.104826. Online ahead of print.ABSTRACTInfectious diseases like leishmaniasis, malaria, HIV, tuberculosis, leprosy and filariasis are responsible for an immense burden on public health systems. Among these, leishmaniasis is under the category I diseases as it is selected by WHO (World Health Organization) on the ground of diversity and complexity. High cost, resistance and toxic effects of Leishmania traditional drugs entail identification and development of therapeutic alternative. Since the natural infection elicits robust immunity, consistence efforts ...
Source: Cellular Immunology - April 26, 2024 Category: Allergy & Immunology Authors: Isha Saini Jyoti Joshi Sukhbir Kaur Source Type: research
Immunological regulation of skeletal muscle adaptation to exercise
Cell Metab. 2024 Apr 17:S1550-4131(24)00121-9. doi: 10.1016/j.cmet.2024.04.001. Online ahead of print.ABSTRACTExercise has long been acknowledged for its powerful disease-preventing, health-promoting effects. However, the cellular and molecular mechanisms responsible for the beneficial effects of exercise are not fully understood. Inflammation is a component of the stress response to exercise. Recent work has revealed that such inflammation is not merely a symptom of exertion; rather, it is a key regulator of exercise adaptations, particularly in skeletal muscle. The purpose of this piece is to provide a conceptual framewo...
Source: Cell Metabolism - April 26, 2024 Category: Cytology Authors: P Kent Langston Diane Mathis Source Type: research
Aspergillus Endogenous Endophthalmitis as a Clue to Identifying a Delayed Lumbosacral Osteomyelitis
CONCLUSION: This case highlights the atypical progression of Aspergillus-induced endogenous endophthalmitis to delayed lumbosacral osteomyelitis in an immunocompetent individual. It highlights the crucial role of a meticulous medical history examination and interdisciplinary collaboration in diagnosing and managing diseases, especially in cases with atypical presentations.PMID:38668792 | DOI:10.1080/09273948.2024.2344704 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 26, 2024 Category: Allergy & Immunology Authors: Muhammed Altinisik Yeliz Delibay Akgun Mustafa Erdogan Azzam Faiz Mutawakkil Horu Gazi Source Type: research
The Great Imitator Masquerading as Autoimmune Hepatitis and Demystifying as Fulminant Syphilitic Retinitis
CONCLUSION: Acquired syphilitic hepatitis is rarely reported. Administering steroids potentially aggravated the infection. The characteristic features of placoid chorioretinitis and punctate inner retinitis connected the pieces of the puzzle together to the diagnosis of ocular and neurosyphilis. Intrahepatic cholestasis with negative serological panel of hepatotropic pathogens should raise the suspicion of non-hepatotropic pathogens especially syphilis.PMID:38669600 | DOI:10.1080/09273948.2024.2345290 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 26, 2024 Category: Allergy & Immunology Authors: Ron Kaufman Juan Martin Sanchez Radgonde Amer Source Type: research
Antimicrobial resistance profile in Salmonella enterica serovar Choleraesuis isolates from diseased pigs in Taiwan
This study investigated antimicrobial resistance in Salmonella enterica serovar Choleraesuis (S. Choleraesuis) isolates from diseased pigs in Taiwan (2015-2020). Among 272 isolates, florfenicol (96.7%), enrofloxacin (96.3%), doxycycline (91.2%), gentamicin (84.6%), and tiamulin (80.5%) exhibited high resistance. 99.3% of the isolates were resistant to at least one antibiotic, and 97.8% of the isolates were multidrug resistant. This study illustrated that S. Choleraesuis isolates exhibited high resistance to antimicrobials currently used in the Taiwanese swine industry.PMID:38670815 | DOI:10.1016/j.jmii.2024.04.005 (Source:...
Source: Journal of Microbiology, Immunology, and Infection - April 26, 2024 Category: Microbiology Authors: Anh Le Xuan Feng-Yang Hsu Po-Ren Hsueh Wei-Hao Lin Hung-Han Chen Ming-Tang Chiou Chao-Nan Lin Source Type: research
Nur77 Mediates Anaphylaxis by Regulating miR-21a
This study aimed to identify molecules that could mediate allergic inflammations. To this end, we performed RNA sequencing analysis employing bone marrow-derived mast cells (BMMCs). Antigen (DNP-HSA) stimulation increased the expression levels of transcription factors such as Nr4a3 (NOR1), Nr4a1 (Nur77), and Nr4a2 (Nurr1). We focused our study on Nur77. Antigen stimulation increased the expression of Nur77 in a time- and dose-dependent manner in rat basophilic leukemia cells (RBL2H3). The downregulation of Nur77 prevented both antigen-induced increase in β-hexosaminidase activity as well as hallmarks of allergic reactions...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Hyein Jo Jaewhoon Jeoung Kyeonghee Shim Dooil Jeoung Source Type: research
Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection
Am J Respir Cell Mol Biol. 2024 Apr 26. doi: 10.1165/rcmb.2023-0395OC. Online ahead of print.ABSTRACTThe bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood. These lung progenitors display distinct microenvironment-specific developmental kinetics compared to their b...
Source: Am J Respir Cell Mol... - April 26, 2024 Category: Respiratory Medicine Authors: Kyle T Mincham Jean-Francois Lauzon-Joset James F Read Patrick G Holt Philip A Stumbles Deborah H Strickland Source Type: research
The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients
In this study, we aimed to know whether the extensive inter and intra heterogeneity of TAMs contributes to the clinical outcomes and indications for immune checkpoint blockade (ICB) in CRC. We used single-cell RNA sequencing (scRNA-Seq) data from 60 CRC patients and charactrized TAMs based on anatomic locations, tumor regions, stages, grades, metastatic status, MSS/MSI classification and pseudotemporal differentiation status. We then defined a catalog of 21 gene modules that determine macrophage status, and identified 7 of them as relevant to clinical outcomes and 11 as indications for ICB therapy. On this basis, we constr...
Source: Immunobiology - April 26, 2024 Category: Allergy & Immunology Authors: Junhui Tang Liang Ming Feiyu Qin Yan Qin Duo Wang Liuying Huang Yulin Cao Zhaohui Huang Yuan Yin Source Type: research
Leishmania vaccine development: A comprehensive review
Cell Immunol. 2024 Apr 23;399-400:104826. doi: 10.1016/j.cellimm.2024.104826. Online ahead of print.ABSTRACTInfectious diseases like leishmaniasis, malaria, HIV, tuberculosis, leprosy and filariasis are responsible for an immense burden on public health systems. Among these, leishmaniasis is under the category I diseases as it is selected by WHO (World Health Organization) on the ground of diversity and complexity. High cost, resistance and toxic effects of Leishmania traditional drugs entail identification and development of therapeutic alternative. Since the natural infection elicits robust immunity, consistence efforts ...
Source: Cellular Immunology - April 26, 2024 Category: Allergy & Immunology Authors: Isha Saini Jyoti Joshi Sukhbir Kaur Source Type: research
Generation of an Inhibitory NK Cell Subset by TGF- β1/IL-15 Polarization
J Immunol. 2024 Apr 26:ji2300834. doi: 10.4049/jimmunol.2300834. Online ahead of print.ABSTRACTNK cells have been shown to exhibit inflammatory and immunoregulatory functions in a variety of healthy and diseased settings. In the context of chronic viral infection and cancer, distinct NK cell populations that inhibit adaptive immune responses have been observed. To understand how these cells arise and further characterize their immunosuppressive role, we examined in vitro conditions that could polarize human NK cells into an inhibitory subset. TGF-β1 has been shown to induce regulatory T cells in vitro and in vivo; we ther...
Source: Journal of Immunology - April 26, 2024 Category: Allergy & Immunology Authors: Douglas C Chung Carlos R Garcia-Batres Douglas G Millar Stephanie W Y Wong Alisha R Elford Jessica A Mathews Ben X Wang Linh T Nguyen Patricia A Shaw Blaise A Clarke Marcus Q Bernardini Adrian G Sacher Sarah Q Crome Pamela S Ohashi Source Type: research
Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages
This study aimed to verify the therapeutic effect of puerarin on HT and explored its regulatory effect on macrophage polarization imbalance in HT. Through bioinformatics analysis and molecular biology methods, it was found that macrophages increased significantly in HT patients and model mice. Immunological staining showed that puerarin intervention could reduce tissue inflammatory cell infiltration. Molecular biological examination displayed that puerarin could inhibit local and systemic inflammation levels, and the expression of marker thyroglobulin and thyroid peroxidase Abs. In vivo experimental results indicated that ...
Source: Journal of Immunology - April 26, 2024 Category: Allergy & Immunology Authors: Qing Tao Yu Chen Qiao Liang Jianfeng Shi Zhiguo Wang Haiyan Min Qian Gao Xiaoming Yao Lei Wang Source Type: research
Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection
Am J Respir Cell Mol Biol. 2024 Apr 26. doi: 10.1165/rcmb.2023-0395OC. Online ahead of print.ABSTRACTThe bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood. These lung progenitors display distinct microenvironment-specific developmental kinetics compared to their b...
Source: American Journal of Respiratory Cell and Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Kyle T Mincham Jean-Francois Lauzon-Joset James F Read Patrick G Holt Philip A Stumbles Deborah H Strickland Source Type: research
Immunological regulation of skeletal muscle adaptation to exercise
Cell Metab. 2024 Apr 17:S1550-4131(24)00121-9. doi: 10.1016/j.cmet.2024.04.001. Online ahead of print.ABSTRACTExercise has long been acknowledged for its powerful disease-preventing, health-promoting effects. However, the cellular and molecular mechanisms responsible for the beneficial effects of exercise are not fully understood. Inflammation is a component of the stress response to exercise. Recent work has revealed that such inflammation is not merely a symptom of exertion; rather, it is a key regulator of exercise adaptations, particularly in skeletal muscle. The purpose of this piece is to provide a conceptual framewo...
Source: Cell Metabolism - April 26, 2024 Category: Cytology Authors: P Kent Langston Diane Mathis Source Type: research
Aspergillus Endogenous Endophthalmitis as a Clue to Identifying a Delayed Lumbosacral Osteomyelitis
CONCLUSION: This case highlights the atypical progression of Aspergillus-induced endogenous endophthalmitis to delayed lumbosacral osteomyelitis in an immunocompetent individual. It highlights the crucial role of a meticulous medical history examination and interdisciplinary collaboration in diagnosing and managing diseases, especially in cases with atypical presentations.PMID:38668792 | DOI:10.1080/09273948.2024.2344704 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 26, 2024 Category: Allergy & Immunology Authors: Muhammed Altinisik Yeliz Delibay Akgun Mustafa Erdogan Azzam Faiz Mutawakkil Horu Gazi Source Type: research
