Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus
CONCLUSION: Apelin-13, possibly by activating the PI3K/AKT pathway, could improve the glucose and lipid metabolism, reduce the damage caused by oxidative stress and inflammatory reaction, and protect the pancreas islet, thereby improving the pregnancy outcome of GDM mice.PMID:34521048 | DOI:10.1016/j.imbio.2021.152135 (Source: Immunobiology)
Source: Immunobiology - September 14, 2021 Category: Allergy & Immunology Authors: Xiao-Dan Zheng Yi Huang Hui Li Source Type: research

Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus
CONCLUSION: Apelin-13, possibly by activating the PI3K/AKT pathway, could improve the glucose and lipid metabolism, reduce the damage caused by oxidative stress and inflammatory reaction, and protect the pancreas islet, thereby improving the pregnancy outcome of GDM mice.PMID:34521048 | DOI:10.1016/j.imbio.2021.152135 (Source: Immunobiology)
Source: Immunobiology - September 14, 2021 Category: Allergy & Immunology Authors: Xiao-Dan Zheng Yi Huang Hui Li Source Type: research

Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus
CONCLUSION: Apelin-13, possibly by activating the PI3K/AKT pathway, could improve the glucose and lipid metabolism, reduce the damage caused by oxidative stress and inflammatory reaction, and protect the pancreas islet, thereby improving the pregnancy outcome of GDM mice.PMID:34521048 | DOI:10.1016/j.imbio.2021.152135 (Source: Immunobiology)
Source: Immunobiology - September 14, 2021 Category: Allergy & Immunology Authors: Xiao-Dan Zheng Yi Huang Hui Li Source Type: research

Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus
CONCLUSION: Apelin-13, possibly by activating the PI3K/AKT pathway, could improve the glucose and lipid metabolism, reduce the damage caused by oxidative stress and inflammatory reaction, and protect the pancreas islet, thereby improving the pregnancy outcome of GDM mice.PMID:34521048 | DOI:10.1016/j.imbio.2021.152135 (Source: Immunobiology)
Source: Immunobiology - September 14, 2021 Category: Allergy & Immunology Authors: Xiao-Dan Zheng Yi Huang Hui Li Source Type: research

Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus
CONCLUSION: Apelin-13, possibly by activating the PI3K/AKT pathway, could improve the glucose and lipid metabolism, reduce the damage caused by oxidative stress and inflammatory reaction, and protect the pancreas islet, thereby improving the pregnancy outcome of GDM mice.PMID:34521048 | DOI:10.1016/j.imbio.2021.152135 (Source: Immunobiology)
Source: Immunobiology - September 14, 2021 Category: Allergy & Immunology Authors: Xiao-Dan Zheng Yi Huang Hui Li Source Type: research

Regulatory role of Apelin-13-mediated PI3K/AKT signaling pathway in the glucose and lipid metabolism of mouse with gestational diabetes mellitus
CONCLUSION: Apelin-13, possibly by activating the PI3K/AKT pathway, could improve the glucose and lipid metabolism, reduce the damage caused by oxidative stress and inflammatory reaction, and protect the pancreas islet, thereby improving the pregnancy outcome of GDM mice.PMID:34521048 | DOI:10.1016/j.imbio.2021.152135 (Source: Immunobiology)
Source: Immunobiology - September 14, 2021 Category: Allergy & Immunology Authors: Xiao-Dan Zheng Yi Huang Hui Li Source Type: research

Bacterial lipoproteins in sepsis
Immunobiology. 2021 Aug 20;226(5):152128. doi: 10.1016/j.imbio.2021.152128. Online ahead of print.ABSTRACTBacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host's virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and...
Source: Immunobiology - September 6, 2021 Category: Allergy & Immunology Authors: Kandahalli Venkataranganayaka Abhilasha Gopal Kedihithlu Marathe Source Type: research

Bacterial lipoproteins in sepsis
Immunobiology. 2021 Aug 20;226(5):152128. doi: 10.1016/j.imbio.2021.152128. Online ahead of print.ABSTRACTBacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host's virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and...
Source: Immunobiology - September 6, 2021 Category: Allergy & Immunology Authors: Kandahalli Venkataranganayaka Abhilasha Gopal Kedihithlu Marathe Source Type: research

Bacterial lipoproteins in sepsis
Immunobiology. 2021 Aug 20;226(5):152128. doi: 10.1016/j.imbio.2021.152128. Online ahead of print.ABSTRACTBacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host's virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and...
Source: Immunobiology - September 6, 2021 Category: Allergy & Immunology Authors: Kandahalli Venkataranganayaka Abhilasha Gopal Kedihithlu Marathe Source Type: research

Bacterial lipoproteins in sepsis
Immunobiology. 2021 Aug 20;226(5):152128. doi: 10.1016/j.imbio.2021.152128. Online ahead of print.ABSTRACTBacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host's virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and...
Source: Immunobiology - September 6, 2021 Category: Allergy & Immunology Authors: Kandahalli Venkataranganayaka Abhilasha Gopal Kedihithlu Marathe Source Type: research

Bacterial lipoproteins in sepsis
Immunobiology. 2021 Aug 20;226(5):152128. doi: 10.1016/j.imbio.2021.152128. Online ahead of print.ABSTRACTBacterial lipoproteins are membrane proteins derived from both gram-negative and gram-positive bacteria. They seem to have diverse functions not only on bacterial growth, but also play an important role in host's virulence. Bacterial lipoproteins exert their action on host immune cells via TLR2/1 or TLR2/6. Therefore, bacterial lipoproteins also need to be considered while addressing bacterial pathogenicity besides classical bacterial endotoxin like LPS and other microbial associated molecular patterns such as LTA, and...
Source: Immunobiology - September 6, 2021 Category: Allergy & Immunology Authors: Kandahalli Venkataranganayaka Abhilasha Gopal Kedihithlu Marathe Source Type: research

Monophosphoryl lipid A directly regulates Th1 cytokine production in human CD4 < sup > + < /sup > T-cells through Toll-like receptor 2 and 4
CONCLUSION: These data provide evidence, at least in part, for the safe induction of an appropriate level of Th1 response by adjuvant MPLA in human vaccine development.PMID:34478947 | DOI:10.1016/j.imbio.2021.152132 (Source: Immunobiology)
Source: Immunobiology - September 3, 2021 Category: Allergy & Immunology Authors: Mousa Komai-Koma Yuan Ji Hui Cao Zhigang Liu Charles McSharry Damo Xu Source Type: research

In-silico immunoinformatic analysis of SARS-CoV-2 virus for the development of putative vaccine construct
This study involves computational and immunoinformatic methods. The Immunoinformatic tools used in the present study are NetCTL server, IFN epitope server, Toxin PRED, BCPred, CTL + HTL + ADJUVANTS + LINKERS, AlgPredserver, VaxiJenserver, ProtParam to predict vaccine construct. The secondary and tertiary structure prediction is done by PSIPRED, I-TASSER, Galaxy refine, prosA + Ramachandran. Finally, docking of the vaccine constructs and ligand was done with the help of Cluspro 2.0. C-ImmSimm webserver to simulate the potential vaccine construct. The present study demonstrated three potential Vaccine constructs for the SARS...
Source: Immunobiology - September 2, 2021 Category: Allergy & Immunology Authors: Abhishek Sharma Surinder Pal Anil Panwar Suresh Kumar Ashok Kumar Source Type: research

Long non-coding RNA RP11-490M8.1 inhibits lipopolysaccharide-induced pyroptosis of human umbilical vein endothelial cells via the TLR4/NF- κB pathway
CONCLUSIONS: These findings indicated that lncRNA RP11-490M8.1 inhibited LPS-induced pyroptosis via the TLR4/NF-κB pathway. Thus, lncRNA RP11-490M8.1 may provide a therapeutic target to ameliorate atherosclerosis.PMID:34469785 | DOI:10.1016/j.imbio.2021.152133 (Source: Immunobiology)
Source: Immunobiology - September 1, 2021 Category: Allergy & Immunology Authors: Xue-Hui Liu Li-Mei Wu Jia-Li Wang Xian-Hui Dong Shun-Chi Zhang Xue-Heng Li Hui Xu Da-Bin Liu Zhi-Hai Li Zhe-Ming Liu Shao-Guo Wu Yan-Wei Hu Source Type: research

Isolation, characterization and in-vitro antigenicity studies of outer membrane proteins (OMPs) of Salmonella gallinarum coated gold nanoparticles (AuNPs)
Immunobiology. 2021 Aug 24;226(5):152131. doi: 10.1016/j.imbio.2021.152131. Online ahead of print.ABSTRACTThe development of biomimetic nanoparticles by combining the natural cellular material with synthetic nanoparticles has inspired innovative therapeutic strategies as compared to traditional line of therapeutics. Therefore, the research was conducted to prepare the outer membrane proteins (OMPs) from Salmonella gallinarum and coated on to the surface of synthetic gold nanoparticles (AuNPs). The size of the final product was characterized by Zeta sizer and Zeta potential. The coating of outer membrane proteins onto the g...
Source: Immunobiology - August 30, 2021 Category: Allergy & Immunology Authors: Majid Anwar Faqir Muhammad Bilal Aslam Muhammad Kashif Saleemi Source Type: research

Infection by Strongyloides venezuelensis attenuates chronic colitis induced by Dextran Sodium Sulfate ingestion in BALB/c mice
In conclusion, S. venezuelensis infection can reduce the severity of DSS-induced chronic colitis in mice possibly through the stimulation of Treg cells and modulatory cytokines, and induction of mucosal repair mechanisms.PMID:34433129 | DOI:10.1016/j.imbio.2021.152129 (Source: Immunobiology)
Source: Immunobiology - August 25, 2021 Category: Allergy & Immunology Authors: Vanessa Fernandes Rodrigues Genil Moror ó Araújo Camelo Michelle Carvalho de Rezende Laura Maggi Jeferson Kelvin Alves Oliveira Silva Jo ão Gustavo Mendes Rodrigues M árcio Sobreira Silva Araújo Olindo Assis Martins-Filho Deborah Negr ão-Corrêa Source Type: research

Infection by Strongyloides venezuelensis attenuates chronic colitis induced by Dextran Sodium Sulfate ingestion in BALB/c mice
In conclusion, S. venezuelensis infection can reduce the severity of DSS-induced chronic colitis in mice possibly through the stimulation of Treg cells and modulatory cytokines, and induction of mucosal repair mechanisms.PMID:34433129 | DOI:10.1016/j.imbio.2021.152129 (Source: Immunobiology)
Source: Immunobiology - August 25, 2021 Category: Allergy & Immunology Authors: Vanessa Fernandes Rodrigues Genil Moror ó Araújo Camelo Michelle Carvalho de Rezende Laura Maggi Jeferson Kelvin Alves Oliveira Silva Jo ão Gustavo Mendes Rodrigues M árcio Sobreira Silva Araújo Olindo Assis Martins-Filho Deborah Negr ão-Corrêa Source Type: research

Infection by Strongyloides venezuelensis attenuates chronic colitis induced by Dextran Sodium Sulfate ingestion in BALB/c mice
In conclusion, S. venezuelensis infection can reduce the severity of DSS-induced chronic colitis in mice possibly through the stimulation of Treg cells and modulatory cytokines, and induction of mucosal repair mechanisms.PMID:34433129 | DOI:10.1016/j.imbio.2021.152129 (Source: Immunobiology)
Source: Immunobiology - August 25, 2021 Category: Allergy & Immunology Authors: Vanessa Fernandes Rodrigues Genil Moror ó Araújo Camelo Michelle Carvalho de Rezende Laura Maggi Jeferson Kelvin Alves Oliveira Silva Jo ão Gustavo Mendes Rodrigues M árcio Sobreira Silva Araújo Olindo Assis Martins-Filho Deborah Negr ão-Corrêa Source Type: research

Infection by Strongyloides venezuelensis attenuates chronic colitis induced by Dextran Sodium Sulfate ingestion in BALB/c mice
In conclusion, S. venezuelensis infection can reduce the severity of DSS-induced chronic colitis in mice possibly through the stimulation of Treg cells and modulatory cytokines, and induction of mucosal repair mechanisms.PMID:34433129 | DOI:10.1016/j.imbio.2021.152129 (Source: Immunobiology)
Source: Immunobiology - August 25, 2021 Category: Allergy & Immunology Authors: Vanessa Fernandes Rodrigues Genil Moror ó Araújo Camelo Michelle Carvalho de Rezende Laura Maggi Jeferson Kelvin Alves Oliveira Silva Jo ão Gustavo Mendes Rodrigues M árcio Sobreira Silva Araújo Olindo Assis Martins-Filho Deborah Negr ão-Corrêa Source Type: research

Infection by Strongyloides venezuelensis attenuates chronic colitis induced by Dextran Sodium Sulfate ingestion in BALB/c mice
In conclusion, S. venezuelensis infection can reduce the severity of DSS-induced chronic colitis in mice possibly through the stimulation of Treg cells and modulatory cytokines, and induction of mucosal repair mechanisms.PMID:34433129 | DOI:10.1016/j.imbio.2021.152129 (Source: Immunobiology)
Source: Immunobiology - August 25, 2021 Category: Allergy & Immunology Authors: Vanessa Fernandes Rodrigues Genil Moror ó Araújo Camelo Michelle Carvalho de Rezende Laura Maggi Jeferson Kelvin Alves Oliveira Silva Jo ão Gustavo Mendes Rodrigues M árcio Sobreira Silva Araújo Olindo Assis Martins-Filho Deborah Negr ão-Corrêa Source Type: research

Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection
Immunobiology. 2021 Aug 17;226(5):152130. doi: 10.1016/j.imbio.2021.152130. Online ahead of print.ABSTRACTIn this review, we highlight the interaction of SARS-CoV-2 virus and host genomes, reporting the current studies on the sequence analysis of SARS-CoV-2 isolates and host genomes from diverse world populations. The main genetic variants that are present in both the virus and host genomes were particularly focused on the ACE2 and TMPRSS2 genes, and their impact on the patients' susceptibility to the virus infection and severity of the disease. Finally, the interaction of the virus and host non-coding RNAs is described in...
Source: Immunobiology - August 23, 2021 Category: Allergy & Immunology Authors: Juliana M Serpeloni Quirino Alves Lima Neto L éia Carolina Lucio Anelisa Ram ão Jaqueline Carvalho de Oliveira Daniela Fiori Gradia Danielle Malheiros Adriano Ferrasa Rafael Marchi David L A Figueiredo Wilson A Silva Enilze M S F Ribeiro Ilce M S C ólu Source Type: research

Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection
Immunobiology. 2021 Aug 17;226(5):152130. doi: 10.1016/j.imbio.2021.152130. Online ahead of print.ABSTRACTIn this review, we highlight the interaction of SARS-CoV-2 virus and host genomes, reporting the current studies on the sequence analysis of SARS-CoV-2 isolates and host genomes from diverse world populations. The main genetic variants that are present in both the virus and host genomes were particularly focused on the ACE2 and TMPRSS2 genes, and their impact on the patients' susceptibility to the virus infection and severity of the disease. Finally, the interaction of the virus and host non-coding RNAs is described in...
Source: Immunobiology - August 23, 2021 Category: Allergy & Immunology Authors: Juliana M Serpeloni Quirino Alves Lima Neto L éia Carolina Lucio Anelisa Ram ão Jaqueline Carvalho de Oliveira Daniela Fiori Gradia Danielle Malheiros Adriano Ferrasa Rafael Marchi David L A Figueiredo Wilson A Silva Enilze M S F Ribeiro Ilce M S C ólu Source Type: research

Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection
Immunobiology. 2021 Aug 17;226(5):152130. doi: 10.1016/j.imbio.2021.152130. Online ahead of print.ABSTRACTIn this review, we highlight the interaction of SARS-CoV-2 virus and host genomes, reporting the current studies on the sequence analysis of SARS-CoV-2 isolates and host genomes from diverse world populations. The main genetic variants that are present in both the virus and host genomes were particularly focused on the ACE2 and TMPRSS2 genes, and their impact on the patients' susceptibility to the virus infection and severity of the disease. Finally, the interaction of the virus and host non-coding RNAs is described in...
Source: Immunobiology - August 23, 2021 Category: Allergy & Immunology Authors: Juliana M Serpeloni Quirino Alves Lima Neto L éia Carolina Lucio Anelisa Ram ão Jaqueline Carvalho de Oliveira Daniela Fiori Gradia Danielle Malheiros Adriano Ferrasa Rafael Marchi David L A Figueiredo Wilson A Silva Enilze M S F Ribeiro Ilce M S C ólu Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

NK-92 cells change their phenotype and function when cocultured with IL-15, IL-18 and trophoblast cells
Immunobiology. 2021 Jul 26;226(5):152125. doi: 10.1016/j.imbio.2021.152125. Online ahead of print.ABSTRACTNK cell development is affected by their cellular microenvironment and cytokines, including IL-15 and IL-18. NK cells can differentiate in secondary lymphoid organs, liver and within the uterus in close contact with trophoblast cells. The aim was to evaluate changes in the NK cell phenotype and function in the presence of IL-15, IL-18 and JEG-3, a trophoblast cell line. When cocultured with JEG-3 cells, IL-15 caused an increase in the number of NKG2D+ NK-92 cells and the intensity of CD127 expression. IL-18 stimulates ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Valentina Mikhailova Evgeniia Khokhlova Polina Grebenkina Zeina Salloum Igor Nikolaenkov Kseniya Markova Alina Davidova Sergey Selkov Dmitriy Sokolov Source Type: research

Butyrate directly decreases human gut lamina propria CD4 T cell function through histone deacetylase (HDAC) inhibition and GPR43 signaling
Immunobiology. 2021 Jul 30;226(5):152126. doi: 10.1016/j.imbio.2021.152126. Online ahead of print.ABSTRACTAn important function of the gut microbiome is the fermentation of non-digestible dietary fibers into short chain fatty acids (SCFAs). The three primary SCFAs: acetate, propionate, and butyrate, are key mediators of metabolism and immune cell function in the gut mucosa. We previously demonstrated that butyrate at high concentrations decreased human gut lamina propria (LP) CD4 T cell activation in response to enteric bacteria exposure in vitro. However, to date, the mechanism by which butyrate alters human gut LP CD4 T ...
Source: Immunobiology - August 8, 2021 Category: Allergy & Immunology Authors: Jon J Kibbie Stephanie M Dillon Tezha A Thompson Christine M Purba Martin D McCarter Cara C Wilson Source Type: research

The different functions of short and long thymic stromal lymphopoietin isoforms in autophagy-mediated asthmatic airway inflammation and remodeling
Immunobiology. 2021 Jul 22;226(5):152124. doi: 10.1016/j.imbio.2021.152124. Online ahead of print.ABSTRACTAsthma is a chronic respiratory disease characterized by airway inflammation and remodeling as well as hyper-responsiveness. Thymic stromal lymphopoietin (TSLP), which is a crucial inflammatory cytokine in immune homeostasis, consists of two isoforms, the long isoform lfTSLP and short isoform sfTSLP. The lfTSLP promotes inflammation and plays a pivotal role in asthma pathogenesis, while sfTSLP had been reported to have anti-asthma effects. Experiments have shown that lfTSLP could induce autophagy in hepatocytes. It is ...
Source: Immunobiology - August 1, 2021 Category: Allergy & Immunology Authors: Jiping Zhao Jintao Zhang Shuangmei Tang Junfei Wang Tian Liu Rong Zeng Weichun Zhu Kangda Zhang Jinxiang Wu Source Type: research

The different functions of short and long thymic stromal lymphopoietin isoforms in autophagy-mediated asthmatic airway inflammation and remodeling
Immunobiology. 2021 Jul 22;226(5):152124. doi: 10.1016/j.imbio.2021.152124. Online ahead of print.ABSTRACTAsthma is a chronic respiratory disease characterized by airway inflammation and remodeling as well as hyper-responsiveness. Thymic stromal lymphopoietin (TSLP), which is a crucial inflammatory cytokine in immune homeostasis, consists of two isoforms, the long isoform lfTSLP and short isoform sfTSLP. The lfTSLP promotes inflammation and plays a pivotal role in asthma pathogenesis, while sfTSLP had been reported to have anti-asthma effects. Experiments have shown that lfTSLP could induce autophagy in hepatocytes. It is ...
Source: Immunobiology - August 1, 2021 Category: Allergy & Immunology Authors: Jiping Zhao Jintao Zhang Shuangmei Tang Junfei Wang Tian Liu Rong Zeng Weichun Zhu Kangda Zhang Jinxiang Wu Source Type: research

The different functions of short and long thymic stromal lymphopoietin isoforms in autophagy-mediated asthmatic airway inflammation and remodeling
Immunobiology. 2021 Jul 22;226(5):152124. doi: 10.1016/j.imbio.2021.152124. Online ahead of print.ABSTRACTAsthma is a chronic respiratory disease characterized by airway inflammation and remodeling as well as hyper-responsiveness. Thymic stromal lymphopoietin (TSLP), which is a crucial inflammatory cytokine in immune homeostasis, consists of two isoforms, the long isoform lfTSLP and short isoform sfTSLP. The lfTSLP promotes inflammation and plays a pivotal role in asthma pathogenesis, while sfTSLP had been reported to have anti-asthma effects. Experiments have shown that lfTSLP could induce autophagy in hepatocytes. It is ...
Source: Immunobiology - August 1, 2021 Category: Allergy & Immunology Authors: Jiping Zhao Jintao Zhang Shuangmei Tang Junfei Wang Tian Liu Rong Zeng Weichun Zhu Kangda Zhang Jinxiang Wu Source Type: research

The different functions of short and long thymic stromal lymphopoietin isoforms in autophagy-mediated asthmatic airway inflammation and remodeling
Immunobiology. 2021 Jul 22;226(5):152124. doi: 10.1016/j.imbio.2021.152124. Online ahead of print.ABSTRACTAsthma is a chronic respiratory disease characterized by airway inflammation and remodeling as well as hyper-responsiveness. Thymic stromal lymphopoietin (TSLP), which is a crucial inflammatory cytokine in immune homeostasis, consists of two isoforms, the long isoform lfTSLP and short isoform sfTSLP. The lfTSLP promotes inflammation and plays a pivotal role in asthma pathogenesis, while sfTSLP had been reported to have anti-asthma effects. Experiments have shown that lfTSLP could induce autophagy in hepatocytes. It is ...
Source: Immunobiology - August 1, 2021 Category: Allergy & Immunology Authors: Jiping Zhao Jintao Zhang Shuangmei Tang Junfei Wang Tian Liu Rong Zeng Weichun Zhu Kangda Zhang Jinxiang Wu Source Type: research

The different functions of short and long thymic stromal lymphopoietin isoforms in autophagy-mediated asthmatic airway inflammation and remodeling
Immunobiology. 2021 Jul 22;226(5):152124. doi: 10.1016/j.imbio.2021.152124. Online ahead of print.ABSTRACTAsthma is a chronic respiratory disease characterized by airway inflammation and remodeling as well as hyper-responsiveness. Thymic stromal lymphopoietin (TSLP), which is a crucial inflammatory cytokine in immune homeostasis, consists of two isoforms, the long isoform lfTSLP and short isoform sfTSLP. The lfTSLP promotes inflammation and plays a pivotal role in asthma pathogenesis, while sfTSLP had been reported to have anti-asthma effects. Experiments have shown that lfTSLP could induce autophagy in hepatocytes. It is ...
Source: Immunobiology - August 1, 2021 Category: Allergy & Immunology Authors: Jiping Zhao Jintao Zhang Shuangmei Tang Junfei Wang Tian Liu Rong Zeng Weichun Zhu Kangda Zhang Jinxiang Wu Source Type: research