Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients
Immunobiology. 2022 Jan 11;227(2):152180. doi: 10.1016/j.imbio.2022.152180. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is characterized by expansion of autoreactive lymphocytes and impaired management of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays a significant role in maintaining the redox homeostasis of cell. The present study aims to investigate the frequency of peripheral B cell subsets and the redox regulation by Nrf2 in SLE patients with variable disease activity. For this, a total of forty (40) SLE patients and twenty (20) age and gender-matched healthy controls (...
Source: Immunobiology - January 15, 2022 Category: Allergy & Immunology Authors: Preeti Gautam Jyotsana Kaushal Aman Sharma Archana Bhatnagar Source Type: research

Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients
Immunobiology. 2022 Jan 11;227(2):152180. doi: 10.1016/j.imbio.2022.152180. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is characterized by expansion of autoreactive lymphocytes and impaired management of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays a significant role in maintaining the redox homeostasis of cell. The present study aims to investigate the frequency of peripheral B cell subsets and the redox regulation by Nrf2 in SLE patients with variable disease activity. For this, a total of forty (40) SLE patients and twenty (20) age and gender-matched healthy controls (...
Source: Immunobiology - January 15, 2022 Category: Allergy & Immunology Authors: Preeti Gautam Jyotsana Kaushal Aman Sharma Archana Bhatnagar Source Type: research

Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients
Immunobiology. 2022 Jan 11;227(2):152180. doi: 10.1016/j.imbio.2022.152180. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is characterized by expansion of autoreactive lymphocytes and impaired management of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays a significant role in maintaining the redox homeostasis of cell. The present study aims to investigate the frequency of peripheral B cell subsets and the redox regulation by Nrf2 in SLE patients with variable disease activity. For this, a total of forty (40) SLE patients and twenty (20) age and gender-matched healthy controls (...
Source: Immunobiology - January 15, 2022 Category: Allergy & Immunology Authors: Preeti Gautam Jyotsana Kaushal Aman Sharma Archana Bhatnagar Source Type: research

Proportion of B cell subsets and Nrf2 mediated redox regulation in systemic lupus erythematosus patients
Immunobiology. 2022 Jan 11;227(2):152180. doi: 10.1016/j.imbio.2022.152180. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is characterized by expansion of autoreactive lymphocytes and impaired management of oxidative stress. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays a significant role in maintaining the redox homeostasis of cell. The present study aims to investigate the frequency of peripheral B cell subsets and the redox regulation by Nrf2 in SLE patients with variable disease activity. For this, a total of forty (40) SLE patients and twenty (20) age and gender-matched healthy controls (...
Source: Immunobiology - January 15, 2022 Category: Allergy & Immunology Authors: Preeti Gautam Jyotsana Kaushal Aman Sharma Archana Bhatnagar Source Type: research

Inflammatory level under different p53 mutation status and the regulation role of curcumin in tumor microenvironment
This study might provide a potential method in tumor personalized treatment aiming immune therapy in different p53 status.PMID:35030341 | DOI:10.1016/j.imbio.2022.152177 (Source: Immunobiology)
Source: Immunobiology - January 14, 2022 Category: Allergy & Immunology Authors: Liping Xu Xiaoli Xie Xinbo Li Wenfang Duan Lei Qiu Huan Liu Ying Luo Source Type: research

Management of pregnancy in hereditary angioedema in a resource constrained setting: Our experience at Chandigarh, North India
Immunobiology. 2022 Jan 5;227(2):152175. doi: 10.1016/j.imbio.2022.152175. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare genetic disorder distinguished clinically by recurrent episodes of non-pruritic swelling. Although pregnancy has been considered a trigger, it may have variable effect on frequency of attacks of HAE. C1-inhibitor (C1-INH) is the treatment of choice for management of HAE during pregnancy. However, because of non-availability of C1-INH therapy in developing countries, fresh-frozen plasma (FFP) and tranexamic acid remain the drugs of choice in pregnancy for treatment of acute attacks a...
Source: Immunobiology - January 11, 2022 Category: Allergy & Immunology Authors: Ankur Kumar Jindal Prabal Barman Sanchi Chawla Anit Kaur Rahul Tyagi Pooja Sikka Seema Chopra Shalvi Mahajan Hilary Longhurst Surjit Singh Source Type: research

Management of pregnancy in hereditary angioedema in a resource constrained setting: Our experience at Chandigarh, North India
Immunobiology. 2022 Jan 5;227(2):152175. doi: 10.1016/j.imbio.2022.152175. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare genetic disorder distinguished clinically by recurrent episodes of non-pruritic swelling. Although pregnancy has been considered a trigger, it may have variable effect on frequency of attacks of HAE. C1-inhibitor (C1-INH) is the treatment of choice for management of HAE during pregnancy. However, because of non-availability of C1-INH therapy in developing countries, fresh-frozen plasma (FFP) and tranexamic acid remain the drugs of choice in pregnancy for treatment of acute attacks a...
Source: Immunobiology - January 11, 2022 Category: Allergy & Immunology Authors: Ankur Kumar Jindal Prabal Barman Sanchi Chawla Anit Kaur Rahul Tyagi Pooja Sikka Seema Chopra Shalvi Mahajan Hilary Longhurst Surjit Singh Source Type: research

Management of pregnancy in hereditary angioedema in a resource constrained setting: Our experience at Chandigarh, North India
Immunobiology. 2022 Jan 5;227(2):152175. doi: 10.1016/j.imbio.2022.152175. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare genetic disorder distinguished clinically by recurrent episodes of non-pruritic swelling. Although pregnancy has been considered a trigger, it may have variable effect on frequency of attacks of HAE. C1-inhibitor (C1-INH) is the treatment of choice for management of HAE during pregnancy. However, because of non-availability of C1-INH therapy in developing countries, fresh-frozen plasma (FFP) and tranexamic acid remain the drugs of choice in pregnancy for treatment of acute attacks a...
Source: Immunobiology - January 11, 2022 Category: Allergy & Immunology Authors: Ankur Kumar Jindal Prabal Barman Sanchi Chawla Anit Kaur Rahul Tyagi Pooja Sikka Seema Chopra Shalvi Mahajan Hilary Longhurst Surjit Singh Source Type: research

Monitoring of autoantibodies against CYP4Z1 in patients with colon, ovarian, or prostate cancer
Immunobiology. 2022 Jan 4;227(2):152174. doi: 10.1016/j.imbio.2021.152174. Online ahead of print.ABSTRACTWe have previously monitored the detection of autoantibodies (aAbs) directed against CYP4Z1 in the sera of breast and lung cancer patients. In the present study, the occurence of anti-CYP4Z1 aAbs in patients suffering from colon (n = 100), ovarian (n = 72), or prostate (n = 85) cancer was examined. Determination of aAbs was done using our previously established ELISA method. On average, the levels of anti-CYP4Z1 aAbs detected in sera from all cancer patients were not significantly higher than controls. No correlations w...
Source: Immunobiology - January 9, 2022 Category: Allergy & Immunology Authors: Christopher Khayeka-Wandabwa Xiaoshuang Ma Yingjie Jia Matthias Bureik Source Type: research

Monitoring of autoantibodies against CYP4Z1 in patients with colon, ovarian, or prostate cancer
Immunobiology. 2022 Jan 4;227(2):152174. doi: 10.1016/j.imbio.2021.152174. Online ahead of print.ABSTRACTWe have previously monitored the detection of autoantibodies (aAbs) directed against CYP4Z1 in the sera of breast and lung cancer patients. In the present study, the occurence of anti-CYP4Z1 aAbs in patients suffering from colon (n = 100), ovarian (n = 72), or prostate (n = 85) cancer was examined. Determination of aAbs was done using our previously established ELISA method. On average, the levels of anti-CYP4Z1 aAbs detected in sera from all cancer patients were not significantly higher than controls. No correlations w...
Source: Immunobiology - January 9, 2022 Category: Allergy & Immunology Authors: Christopher Khayeka-Wandabwa Xiaoshuang Ma Yingjie Jia Matthias Bureik Source Type: research

Monitoring of autoantibodies against CYP4Z1 in patients with colon, ovarian, or prostate cancer
Immunobiology. 2022 Jan 4;227(2):152174. doi: 10.1016/j.imbio.2021.152174. Online ahead of print.ABSTRACTWe have previously monitored the detection of autoantibodies (aAbs) directed against CYP4Z1 in the sera of breast and lung cancer patients. In the present study, the occurence of anti-CYP4Z1 aAbs in patients suffering from colon (n = 100), ovarian (n = 72), or prostate (n = 85) cancer was examined. Determination of aAbs was done using our previously established ELISA method. On average, the levels of anti-CYP4Z1 aAbs detected in sera from all cancer patients were not significantly higher than controls. No correlations w...
Source: Immunobiology - January 9, 2022 Category: Allergy & Immunology Authors: Christopher Khayeka-Wandabwa Xiaoshuang Ma Yingjie Jia Matthias Bureik Source Type: research

Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model
This study unveils a novel mechanism by which HNSCC evades NK cell killing, and sheds light on designing novel anti-HNSCC immunotherapy targeting Bat3 and Tim-3 signaling.PMID:34968777 | DOI:10.1016/j.imbio.2021.152127 (Source: Immunobiology)
Source: Immunobiology - December 30, 2021 Category: Allergy & Immunology Authors: Jiyong Yang Jun Xiang Meiling Zhu Yuman Zhao Lei Zhou Binbin Hu Cheng Wang Source Type: research

Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model
This study unveils a novel mechanism by which HNSCC evades NK cell killing, and sheds light on designing novel anti-HNSCC immunotherapy targeting Bat3 and Tim-3 signaling.PMID:34968777 | DOI:10.1016/j.imbio.2021.152127 (Source: Immunobiology)
Source: Immunobiology - December 30, 2021 Category: Allergy & Immunology Authors: Jiyong Yang Jun Xiang Meiling Zhu Yuman Zhao Lei Zhou Binbin Hu Cheng Wang Source Type: research

Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model
This study unveils a novel mechanism by which HNSCC evades NK cell killing, and sheds light on designing novel anti-HNSCC immunotherapy targeting Bat3 and Tim-3 signaling.PMID:34968777 | DOI:10.1016/j.imbio.2021.152127 (Source: Immunobiology)
Source: Immunobiology - December 30, 2021 Category: Allergy & Immunology Authors: Jiyong Yang Jun Xiang Meiling Zhu Yuman Zhao Lei Zhou Binbin Hu Cheng Wang Source Type: research

Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model
This study unveils a novel mechanism by which HNSCC evades NK cell killing, and sheds light on designing novel anti-HNSCC immunotherapy targeting Bat3 and Tim-3 signaling.PMID:34968777 | DOI:10.1016/j.imbio.2021.152127 (Source: Immunobiology)
Source: Immunobiology - December 30, 2021 Category: Allergy & Immunology Authors: Jiyong Yang Jun Xiang Meiling Zhu Yuman Zhao Lei Zhou Binbin Hu Cheng Wang Source Type: research

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Immunobiology. 2021 Dec 17;227(1):152166. doi: 10.1016/j.imbio.2021.152166. Online ahead of print.ABSTRACTSoluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mi...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Diego Jos é Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gon çales Ana Karine Ara újo Soares Kamila K ássia Dos Santos Oliveira Leyllane Rafael Moreira Carolina Medeiros Maria da Gloria Aureliano Melo Cavalcanti S ílvia Source Type: research

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation
Immunobiology. 2021 Dec 15;227(1):152165. doi: 10.1016/j.imbio.2021.152165. Online ahead of print.ABSTRACTChronic inflammation contributes to cancer development and progression. Although interleukin-1beta (IL-1β) has been observed to be associated with an general immune suppression of T cell response and the immunosuppression strongly correlates with accumulation of myeloid-derived suppressor cells (MDSCs), the relationship and mechanism between MDSCs expansion and IL-1β expression remain ambiguous. Here, we showed that the concentration of IL-1β was highly correlated with G-MDSC subset, rather than mo-MDSC ...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Huifang Shi Yan Qin Yufeng Tian Jiaan Wang Yan Wang Ziyi Wang Jie Lv Source Type: research

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Immunobiology. 2021 Dec 17;227(1):152166. doi: 10.1016/j.imbio.2021.152166. Online ahead of print.ABSTRACTSoluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mi...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Diego Jos é Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gon çales Ana Karine Ara újo Soares Kamila K ássia Dos Santos Oliveira Leyllane Rafael Moreira Carolina Medeiros Maria da Gloria Aureliano Melo Cavalcanti S ílvia Source Type: research

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation
Immunobiology. 2021 Dec 15;227(1):152165. doi: 10.1016/j.imbio.2021.152165. Online ahead of print.ABSTRACTChronic inflammation contributes to cancer development and progression. Although interleukin-1beta (IL-1β) has been observed to be associated with an general immune suppression of T cell response and the immunosuppression strongly correlates with accumulation of myeloid-derived suppressor cells (MDSCs), the relationship and mechanism between MDSCs expansion and IL-1β expression remain ambiguous. Here, we showed that the concentration of IL-1β was highly correlated with G-MDSC subset, rather than mo-MDSC ...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Huifang Shi Yan Qin Yufeng Tian Jiaan Wang Yan Wang Ziyi Wang Jie Lv Source Type: research

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Immunobiology. 2021 Dec 17;227(1):152166. doi: 10.1016/j.imbio.2021.152166. Online ahead of print.ABSTRACTSoluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mi...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Diego Jos é Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gon çales Ana Karine Ara újo Soares Kamila K ássia Dos Santos Oliveira Leyllane Rafael Moreira Carolina Medeiros Maria da Gloria Aureliano Melo Cavalcanti S ílvia Source Type: research

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation
Immunobiology. 2021 Dec 15;227(1):152165. doi: 10.1016/j.imbio.2021.152165. Online ahead of print.ABSTRACTChronic inflammation contributes to cancer development and progression. Although interleukin-1beta (IL-1β) has been observed to be associated with an general immune suppression of T cell response and the immunosuppression strongly correlates with accumulation of myeloid-derived suppressor cells (MDSCs), the relationship and mechanism between MDSCs expansion and IL-1β expression remain ambiguous. Here, we showed that the concentration of IL-1β was highly correlated with G-MDSC subset, rather than mo-MDSC ...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Huifang Shi Yan Qin Yufeng Tian Jiaan Wang Yan Wang Ziyi Wang Jie Lv Source Type: research

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Immunobiology. 2021 Dec 17;227(1):152166. doi: 10.1016/j.imbio.2021.152166. Online ahead of print.ABSTRACTSoluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mi...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Diego Jos é Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gon çales Ana Karine Ara újo Soares Kamila K ássia Dos Santos Oliveira Leyllane Rafael Moreira Carolina Medeiros Maria da Gloria Aureliano Melo Cavalcanti S ílvia Source Type: research

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation
Immunobiology. 2021 Dec 15;227(1):152165. doi: 10.1016/j.imbio.2021.152165. Online ahead of print.ABSTRACTChronic inflammation contributes to cancer development and progression. Although interleukin-1beta (IL-1β) has been observed to be associated with an general immune suppression of T cell response and the immunosuppression strongly correlates with accumulation of myeloid-derived suppressor cells (MDSCs), the relationship and mechanism between MDSCs expansion and IL-1β expression remain ambiguous. Here, we showed that the concentration of IL-1β was highly correlated with G-MDSC subset, rather than mo-MDSC ...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Huifang Shi Yan Qin Yufeng Tian Jiaan Wang Yan Wang Ziyi Wang Jie Lv Source Type: research

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Immunobiology. 2021 Dec 17;227(1):152166. doi: 10.1016/j.imbio.2021.152166. Online ahead of print.ABSTRACTSoluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mi...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Diego Jos é Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gon çales Ana Karine Ara újo Soares Kamila K ássia Dos Santos Oliveira Leyllane Rafael Moreira Carolina Medeiros Maria da Gloria Aureliano Melo Cavalcanti S ílvia Source Type: research

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation
Immunobiology. 2021 Dec 15;227(1):152165. doi: 10.1016/j.imbio.2021.152165. Online ahead of print.ABSTRACTChronic inflammation contributes to cancer development and progression. Although interleukin-1beta (IL-1β) has been observed to be associated with an general immune suppression of T cell response and the immunosuppression strongly correlates with accumulation of myeloid-derived suppressor cells (MDSCs), the relationship and mechanism between MDSCs expansion and IL-1β expression remain ambiguous. Here, we showed that the concentration of IL-1β was highly correlated with G-MDSC subset, rather than mo-MDSC ...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Huifang Shi Yan Qin Yufeng Tian Jiaan Wang Yan Wang Ziyi Wang Jie Lv Source Type: research

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Immunobiology. 2021 Dec 17;227(1):152166. doi: 10.1016/j.imbio.2021.152166. Online ahead of print.ABSTRACTSoluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mi...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Diego Jos é Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gon çales Ana Karine Ara újo Soares Kamila K ássia Dos Santos Oliveira Leyllane Rafael Moreira Carolina Medeiros Maria da Gloria Aureliano Melo Cavalcanti S ílvia Source Type: research

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation
Immunobiology. 2021 Dec 15;227(1):152165. doi: 10.1016/j.imbio.2021.152165. Online ahead of print.ABSTRACTChronic inflammation contributes to cancer development and progression. Although interleukin-1beta (IL-1β) has been observed to be associated with an general immune suppression of T cell response and the immunosuppression strongly correlates with accumulation of myeloid-derived suppressor cells (MDSCs), the relationship and mechanism between MDSCs expansion and IL-1β expression remain ambiguous. Here, we showed that the concentration of IL-1β was highly correlated with G-MDSC subset, rather than mo-MDSC ...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Huifang Shi Yan Qin Yufeng Tian Jiaan Wang Yan Wang Ziyi Wang Jie Lv Source Type: research

Is a negative correlation between sTNFR1 and TNF in patients with chronic Chagas disease the key to clinical progression?
Immunobiology. 2021 Dec 17;227(1):152166. doi: 10.1016/j.imbio.2021.152166. Online ahead of print.ABSTRACTSoluble TNF receptors (sTNFR1 and sTNFR2) are natural endogenous inhibitors of TNF and are elevated in inflammatory, autoimmune, and chronic degenerative diseases. In Chagas disease, pleiotropic cytokine TNF is considered key in immunopathology. Thus, we aimed to evaluate the levels of TNF, sTNFR1, and sTNFR2 in the serum of patients with chronic Chagas disease. TNF and its soluble receptors were quantified using Cytometric Bead Array in the serum of 132 patients, of which 51 had the indeterminate form (IND), 39 the mi...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Diego Jos é Lira Torres Tiago Ribeiro De Arruda Michelle da Silva Barros Juliana Prado Gon çales Ana Karine Ara újo Soares Kamila K ássia Dos Santos Oliveira Leyllane Rafael Moreira Carolina Medeiros Maria da Gloria Aureliano Melo Cavalcanti S ílvia Source Type: research

Interleukin-1beta triggers the expansion of circulating granulocytic myeloid-derived suppressor cell subset dependent on Erk1/2 activation
Immunobiology. 2021 Dec 15;227(1):152165. doi: 10.1016/j.imbio.2021.152165. Online ahead of print.ABSTRACTChronic inflammation contributes to cancer development and progression. Although interleukin-1beta (IL-1β) has been observed to be associated with an general immune suppression of T cell response and the immunosuppression strongly correlates with accumulation of myeloid-derived suppressor cells (MDSCs), the relationship and mechanism between MDSCs expansion and IL-1β expression remain ambiguous. Here, we showed that the concentration of IL-1β was highly correlated with G-MDSC subset, rather than mo-MDSC ...
Source: Immunobiology - December 22, 2021 Category: Allergy & Immunology Authors: Huifang Shi Yan Qin Yufeng Tian Jiaan Wang Yan Wang Ziyi Wang Jie Lv Source Type: research

Association between peripheral blood WBCs C3aR mRNA level and plasma C3a, C3aR, IL-1 β concentrations and acute exacerbation of chronic obstructive pulmonary disease
This study aims to explore the expression levels of C3aR in peripheral blood WBCs and the concentrations of C3a, C3aR, and IL-1β in plasma in healthy controls and patients with chronic obstructive pulmonary disease (COPD).METHODS: WBCs C3aR level in the peripheral blood, the concentrations of C3a, C3aR, and IL-1β in plasma were measured in 60 patients with acute exacerbation of COPD (AECOPD), 30 patients with stable COPD (SCOPD), and 30 healthy controls. The baseline characteristics and clinical data collected from enrolled patients, including age, gender, laboratory indicators, and lung function. We analyzed the...
Source: Immunobiology - December 19, 2021 Category: Allergy & Immunology Authors: Zhu Li Peiyong He Hongwei Ding Ling Gong Jie Wu Chengyao Zhong Daishun Liu Source Type: research

Association between peripheral blood WBCs C3aR mRNA level and plasma C3a, C3aR, IL-1 β concentrations and acute exacerbation of chronic obstructive pulmonary disease
This study aims to explore the expression levels of C3aR in peripheral blood WBCs and the concentrations of C3a, C3aR, and IL-1β in plasma in healthy controls and patients with chronic obstructive pulmonary disease (COPD).METHODS: WBCs C3aR level in the peripheral blood, the concentrations of C3a, C3aR, and IL-1β in plasma were measured in 60 patients with acute exacerbation of COPD (AECOPD), 30 patients with stable COPD (SCOPD), and 30 healthy controls. The baseline characteristics and clinical data collected from enrolled patients, including age, gender, laboratory indicators, and lung function. We analyzed the...
Source: Immunobiology - December 19, 2021 Category: Allergy & Immunology Authors: Zhu Li Peiyong He Hongwei Ding Ling Gong Jie Wu Chengyao Zhong Daishun Liu Source Type: research

Association between peripheral blood WBCs C3aR mRNA level and plasma C3a, C3aR, IL-1 β concentrations and acute exacerbation of chronic obstructive pulmonary disease
This study aims to explore the expression levels of C3aR in peripheral blood WBCs and the concentrations of C3a, C3aR, and IL-1β in plasma in healthy controls and patients with chronic obstructive pulmonary disease (COPD).METHODS: WBCs C3aR level in the peripheral blood, the concentrations of C3a, C3aR, and IL-1β in plasma were measured in 60 patients with acute exacerbation of COPD (AECOPD), 30 patients with stable COPD (SCOPD), and 30 healthy controls. The baseline characteristics and clinical data collected from enrolled patients, including age, gender, laboratory indicators, and lung function. We analyzed the...
Source: Immunobiology - December 19, 2021 Category: Allergy & Immunology Authors: Zhu Li Peiyong He Hongwei Ding Ling Gong Jie Wu Chengyao Zhong Daishun Liu Source Type: research

LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163 (Source: Immunobiology)
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research

LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163 (Source: Immunobiology)
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research

LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163 (Source: Immunobiology)
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research

LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163 (Source: Immunobiology)
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research

LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163 (Source: Immunobiology)
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research

Humoral immune responses against facultative pathogen Candida utilis in atopic patients with vulvovaginal candidiasis. Candida utilis glucomannan - New serologic biomarker
In this study we assessed the immunobiological activity of facultative pathogen Candida utilis cell glucomannan and its effectivity as in vitro serological marker for antibody testing. The novel serologic assay has been developed and optimized for C. utilis serodiagnosis. The comparison assays were performed to establish relationship between antibodies against C. utilis, C. albicans and S. cerevisiae main cell-wall antigens in patient sera. The study evaluates applicability of glucomannan as serodiagnostic antigen and as a trigger of antigenspecific IgG, IgM and IgA antibody isotypes in the cohort of 35 atopic female subje...
Source: Immunobiology - November 26, 2021 Category: Allergy & Immunology Authors: E Paulovi čová M Hrubi ško Source Type: research