The role of C5a receptors in autoimmunity
Immunobiology. 2023 Jun 20;228(5):152413. doi: 10.1016/j.imbio.2023.152413. Online ahead of print.ABSTRACTThe complement system is an essential component of the innate immune response and plays a vital role in host defense and inflammation. Dysregulation of the complement system, particularly involving the anaphylatoxin C5a and its receptors (C5aR1 and C5aR2), has been linked to several autoimmune diseases, indicating the potential for targeted therapies. C5aR1 and C5aR2 are seven-transmembrane receptors with distinct signaling mechanisms that play both partially overlapping and opposing roles in immunity. Both receptors a...
Source: Immunobiology - August 20, 2023 Category: Allergy & Immunology Authors: Jovan Schanzenbacher Katja Hendrika K ähler Evelyn Mesler Marie Kleingarn Christian Marcel Karsten Daniel Leonard Seiler Source Type: research
The role of C5a receptors in autoimmunity
Immunobiology. 2023 Jun 20;228(5):152413. doi: 10.1016/j.imbio.2023.152413. Online ahead of print.ABSTRACTThe complement system is an essential component of the innate immune response and plays a vital role in host defense and inflammation. Dysregulation of the complement system, particularly involving the anaphylatoxin C5a and its receptors (C5aR1 and C5aR2), has been linked to several autoimmune diseases, indicating the potential for targeted therapies. C5aR1 and C5aR2 are seven-transmembrane receptors with distinct signaling mechanisms that play both partially overlapping and opposing roles in immunity. Both receptors a...
Source: Immunobiology - August 20, 2023 Category: Allergy & Immunology Authors: Jovan Schanzenbacher Katja Hendrika K ähler Evelyn Mesler Marie Kleingarn Christian Marcel Karsten Daniel Leonard Seiler Source Type: research
Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations
In this study, we used various methods to obtain shared biomarkers derived from multiple tissue in pSS patients and to explore their relationship with immune microenvironment alterations. First we identified differentially expressed genes (DEGs) between pSS and healthy controls utilizing nine mRNA microarray datasets obtained from the Gene Expression Omnibus (GEO). Then, shared biomarkers were filtered out using robust rank aggregation (RRA), data integration analysis, weighted gene co-expression network analysis (WGCNA), and least absolute selection and shrinkage operator (LASSO) regression; their roles in pSS and associa...
Source: Immunobiology - August 17, 2023 Category: Allergy & Immunology Authors: Tiantian Cai Jianbin Xu Yudie Fang Yuqing Wu Qiu Qin Jin-An Zhang Source Type: research
Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations
In this study, we used various methods to obtain shared biomarkers derived from multiple tissue in pSS patients and to explore their relationship with immune microenvironment alterations. First we identified differentially expressed genes (DEGs) between pSS and healthy controls utilizing nine mRNA microarray datasets obtained from the Gene Expression Omnibus (GEO). Then, shared biomarkers were filtered out using robust rank aggregation (RRA), data integration analysis, weighted gene co-expression network analysis (WGCNA), and least absolute selection and shrinkage operator (LASSO) regression; their roles in pSS and associa...
Source: Immunobiology - August 17, 2023 Category: Allergy & Immunology Authors: Tiantian Cai Jianbin Xu Yudie Fang Yuqing Wu Qiu Qin Jin-An Zhang Source Type: research
Shared biomarkers of multi-tissue origin for primary Sjogren's syndrome and their importance in immune microenvironment alterations
In this study, we used various methods to obtain shared biomarkers derived from multiple tissue in pSS patients and to explore their relationship with immune microenvironment alterations. First we identified differentially expressed genes (DEGs) between pSS and healthy controls utilizing nine mRNA microarray datasets obtained from the Gene Expression Omnibus (GEO). Then, shared biomarkers were filtered out using robust rank aggregation (RRA), data integration analysis, weighted gene co-expression network analysis (WGCNA), and least absolute selection and shrinkage operator (LASSO) regression; their roles in pSS and associa...
Source: Immunobiology - August 17, 2023 Category: Allergy & Immunology Authors: Tiantian Cai Jianbin Xu Yudie Fang Yuqing Wu Qiu Qin Jin-An Zhang Source Type: research
A retrospective observational study to estimate the risk of HLA alloimmunization with blood transfusion: Can the risk be reduced by leucodepletion?
CONCLUSION: Patients who received LD RBC units had a significantly lower rate of transfusion-associated alloimmunization compared to those who received non-LD RBC units. Multiparous women had a high risk for transfusion-related alloimmunization compared to both nulliparous women and male patient. Furthermore, class I-anti-HLA-antibodies (HLA-B and HLA-A + B) were significantly associated with pregnancy sensitization and/or blood transfusion as a single sensitization.PMID:37586300 | DOI:10.1016/j.imbio.2023.152727 (Source: Immunobiology)
Source: Immunobiology - August 16, 2023 Category: Allergy & Immunology Authors: Prashant Pandey Amit Pande Arghyadeep Marik Vijay Kumar Sinha Amit Kumar Devra Anil Prasad Bhatt Supriya Kumari Swapnil Yashwant Gajway Ravi Kumar Singh Smriti Mishra Shantanu Jha Source Type: research
Identification of prognostic genes for breast cancer related to systemic lupus erythematosus by integrated analysis and machine learning
CONCLUSION: IRF7, IFI35 and EIF2AK2, were identified as prognostic genes for BRCA related to SLE. IFN pathway played an important role in the etiology of SLE and the prognosis of BRCA.PMID:37582308 | DOI:10.1016/j.imbio.2023.152730 (Source: Immunobiology)
Source: Immunobiology - August 15, 2023 Category: Allergy & Immunology Authors: Xiaofeng Liang Zhishen Peng Zien Lin Xiaobing Lin Weiyi Lin Ying Deng Shujun Yang Shanshan Wei Source Type: research
Identification of prognostic genes for breast cancer related to systemic lupus erythematosus by integrated analysis and machine learning
CONCLUSION: IRF7, IFI35 and EIF2AK2, were identified as prognostic genes for BRCA related to SLE. IFN pathway played an important role in the etiology of SLE and the prognosis of BRCA.PMID:37582308 | DOI:10.1016/j.imbio.2023.152730 (Source: Immunobiology)
Source: Immunobiology - August 15, 2023 Category: Allergy & Immunology Authors: Xiaofeng Liang Zhishen Peng Zien Lin Xiaobing Lin Weiyi Lin Ying Deng Shujun Yang Shanshan Wei Source Type: research
Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis
This study hypothesizes that the pro-inflammatory Annexin A2 (ANXA2) has role in COVID-19 pathogenesis. In thisobservational study, serum levels of ANXA2 along with interleukin 1 beta (IL1β), IL6, tumour necrosis factor-alpha (TNFα), and anti-inflammatory ANXA1 were determined by sandwich ELISA in 20 each control, mild, moderate, and severe COVID-19 subjects.The ANXA2 levels (130 ng/mL, p < 0.001) were significantly elevated in severe COVID-19 subjects, compared to mild, moderate and controls. Similarly, all the other pro-inflammatory biomarkers levels were also significantly correlated with disease severity (p < 0...
Source: Immunobiology - August 14, 2023 Category: Allergy & Immunology Authors: Rathika D Shenoy None Nithin Kuriakose None Vijaykrishnaraj M Prakash Patil Pavan K Jayaswamy Dhananjay B Alagundagi Praveenkumar Shetty Source Type: research
Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis
This study hypothesizes that the pro-inflammatory Annexin A2 (ANXA2) has role in COVID-19 pathogenesis. In thisobservational study, serum levels of ANXA2 along with interleukin 1 beta (IL1β), IL6, tumour necrosis factor-alpha (TNFα), and anti-inflammatory ANXA1 were determined by sandwich ELISA in 20 each control, mild, moderate, and severe COVID-19 subjects.The ANXA2 levels (130 ng/mL, p < 0.001) were significantly elevated in severe COVID-19 subjects, compared to mild, moderate and controls. Similarly, all the other pro-inflammatory biomarkers levels were also significantly correlated with disease severity (p < 0...
Source: Immunobiology - August 14, 2023 Category: Allergy & Immunology Authors: Rathika D Shenoy None Nithin Kuriakose None Vijaykrishnaraj M Prakash Patil Pavan K Jayaswamy Dhananjay B Alagundagi Praveenkumar Shetty Source Type: research
Metabolomic and proteomic analyses of primary Sjogren's syndrome
In this study, the progression mechanism of pSS was analyzed and novel biomarkers were identified by proteomics and metabolomics.PMID:37567091 | DOI:10.1016/j.imbio.2023.152722 (Source: Immunobiology)
Source: Immunobiology - August 11, 2023 Category: Allergy & Immunology Authors: Junning Zhang Zixing Tang Zhenyu Liu Guangyu Wang Xueli Yang Xianliang Hou Source Type: research
Metabolomic and proteomic analyses of primary Sjogren's syndrome
In this study, the progression mechanism of pSS was analyzed and novel biomarkers were identified by proteomics and metabolomics.PMID:37567091 | DOI:10.1016/j.imbio.2023.152722 (Source: Immunobiology)
Source: Immunobiology - August 11, 2023 Category: Allergy & Immunology Authors: Junning Zhang Zixing Tang Zhenyu Liu Guangyu Wang Xueli Yang Xianliang Hou Source Type: research
Metabolomic and proteomic analyses of primary Sjogren's syndrome
In this study, the progression mechanism of pSS was analyzed and novel biomarkers were identified by proteomics and metabolomics.PMID:37567091 | DOI:10.1016/j.imbio.2023.152722 (Source: Immunobiology)
Source: Immunobiology - August 11, 2023 Category: Allergy & Immunology Authors: Junning Zhang Zixing Tang Zhenyu Liu Guangyu Wang Xueli Yang Xianliang Hou Source Type: research
TLR-2 agonist Pam3CSK4 has no therapeutic effect on visceral leishmaniasis in BALB/c mice and may enhance the pathogenesis of the disease
In this study, TLR-2 agonist Pam3CSK4 showed no therapeutic effect on visceral leishmaniasis in BALB/c mice and might enhance the pathogenesis of the disease possibly due to the down-regulation of several immune-related pathways, which can improve our understanding of the role of TLR-2 in both treatment and vaccine development.PMID:37562277 | DOI:10.1016/j.imbio.2023.152725 (Source: Immunobiology)
Source: Immunobiology - August 10, 2023 Category: Allergy & Immunology Authors: Xuechun Liao Jinlei He Ruanyan Wang Jianhui Zhang Shulan Wei Yuying Xiao Qi Zhou Xiaoting Zheng Zheying Zhu Zhiwan Zheng Jiao Li Zheng Zeng Dali Chen Jianping Chen Source Type: research
TLR-2 agonist Pam3CSK4 has no therapeutic effect on visceral leishmaniasis in BALB/c mice and may enhance the pathogenesis of the disease
In this study, TLR-2 agonist Pam3CSK4 showed no therapeutic effect on visceral leishmaniasis in BALB/c mice and might enhance the pathogenesis of the disease possibly due to the down-regulation of several immune-related pathways, which can improve our understanding of the role of TLR-2 in both treatment and vaccine development.PMID:37562277 | DOI:10.1016/j.imbio.2023.152725 (Source: Immunobiology)
Source: Immunobiology - August 10, 2023 Category: Allergy & Immunology Authors: Xuechun Liao Jinlei He Ruanyan Wang Jianhui Zhang Shulan Wei Yuying Xiao Qi Zhou Xiaoting Zheng Zheying Zhu Zhiwan Zheng Jiao Li Zheng Zeng Dali Chen Jianping Chen Source Type: research
