PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children
Immunobiology. 2023 Aug 3;228(5):152724. doi: 10.1016/j.imbio.2023.152724. Online ahead of print.ABSTRACTPDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D genetic variants have been associated with asthma susceptibility. Therefore, this study aimed to investigate the association between PDE4D variants (and haplotypes) with asthma and atopy in a Brazilian population. The study comprised 1,246 unrelated participants from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was performed using the Illumina 2.5 Human Omni bead chip. Multivariate logistic regression was us...
Source: Immunobiology - August 7, 2023 Category: Allergy & Immunology Authors: Hatilla Dos Santos Silva Helena Mariana Pitangueira Teixeira Luciano Gama da Silva Gomes Álvaro A Cruz Neuza Maria Alcantara-Neves Maur ício Barreto Camila Alexandrina Figueiredo Ryan Dos Santos Costa Source Type: research
PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children
Immunobiology. 2023 Aug 3;228(5):152724. doi: 10.1016/j.imbio.2023.152724. Online ahead of print.ABSTRACTPDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D genetic variants have been associated with asthma susceptibility. Therefore, this study aimed to investigate the association between PDE4D variants (and haplotypes) with asthma and atopy in a Brazilian population. The study comprised 1,246 unrelated participants from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was performed using the Illumina 2.5 Human Omni bead chip. Multivariate logistic regression was us...
Source: Immunobiology - August 7, 2023 Category: Allergy & Immunology Authors: Hatilla Dos Santos Silva Helena Mariana Pitangueira Teixeira Luciano Gama da Silva Gomes Álvaro A Cruz Neuza Maria Alcantara-Neves Maur ício Barreto Camila Alexandrina Figueiredo Ryan Dos Santos Costa Source Type: research
PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children
Immunobiology. 2023 Aug 3;228(5):152724. doi: 10.1016/j.imbio.2023.152724. Online ahead of print.ABSTRACTPDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D genetic variants have been associated with asthma susceptibility. Therefore, this study aimed to investigate the association between PDE4D variants (and haplotypes) with asthma and atopy in a Brazilian population. The study comprised 1,246 unrelated participants from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was performed using the Illumina 2.5 Human Omni bead chip. Multivariate logistic regression was us...
Source: Immunobiology - August 7, 2023 Category: Allergy & Immunology Authors: Hatilla Dos Santos Silva Helena Mariana Pitangueira Teixeira Luciano Gama da Silva Gomes Álvaro A Cruz Neuza Maria Alcantara-Neves Maur ício Barreto Camila Alexandrina Figueiredo Ryan Dos Santos Costa Source Type: research
Clinical study of autonomic dysfunction in patients with autoimmune encephalitis
CONCLUSION: This study demonstrated the comparisons between autonomic dysfunction group and autonomic dysfunction-free group and provided insights into better diagnosis and treatment.PMID:37543010 | DOI:10.1016/j.imbio.2023.152711 (Source: Immunobiology)
Source: Immunobiology - August 5, 2023 Category: Allergy & Immunology Authors: Jiao He Yajun Lian Source Type: research
Clinical study of autonomic dysfunction in patients with autoimmune encephalitis
CONCLUSION: This study demonstrated the comparisons between autonomic dysfunction group and autonomic dysfunction-free group and provided insights into better diagnosis and treatment.PMID:37543010 | DOI:10.1016/j.imbio.2023.152711 (Source: Immunobiology)
Source: Immunobiology - August 5, 2023 Category: Allergy & Immunology Authors: Jiao He Yajun Lian Source Type: research
Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains
Immunobiology. 2023 Jul 28;228(5):152720. doi: 10.1016/j.imbio.2023.152720. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of severe COVID-19 disease can be challenging in immunocompromized patients due to newly emerging virus variants of concern (VOC) escaping the humoral response. Thus, T cells recognizing to date unmutated epitopes are not only relevant for patients' immune responses against VOC, but might also serve as a therapeutic option for patients with severe COVID-19 disease in the future, e.g. following allogenic stem cell transplantation.METHODS: To this purpose, the activation, cytokine profile and spec...
Source: Immunobiology - August 4, 2023 Category: Allergy & Immunology Authors: Hannah Reimann Carolin Moosmann Kilian Schober Vanessa Lang Johan Verhagen Julia Zeun Andreas Mackensen Anita N Kremer Simon V ölkl Michael Aigner Source Type: research
Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains
Immunobiology. 2023 Jul 28;228(5):152720. doi: 10.1016/j.imbio.2023.152720. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of severe COVID-19 disease can be challenging in immunocompromized patients due to newly emerging virus variants of concern (VOC) escaping the humoral response. Thus, T cells recognizing to date unmutated epitopes are not only relevant for patients' immune responses against VOC, but might also serve as a therapeutic option for patients with severe COVID-19 disease in the future, e.g. following allogenic stem cell transplantation.METHODS: To this purpose, the activation, cytokine profile and spec...
Source: Immunobiology - August 4, 2023 Category: Allergy & Immunology Authors: Hannah Reimann Carolin Moosmann Kilian Schober Vanessa Lang Johan Verhagen Julia Zeun Andreas Mackensen Anita N Kremer Simon V ölkl Michael Aigner Source Type: research
Limosilactobacillus fermentum modulates the gut-airway axis by improving the immune response through FOXP3 activation on combined allergic rhinitis and asthma syndrome (CARAS)
Immunobiology. 2023 Jul 26;228(5):152721. doi: 10.1016/j.imbio.2023.152721. Online ahead of print.ABSTRACTCombined allergic rhinitis and asthma syndrome (CARAS) is an allergic airway inflammatory disorder orchestrated by the type 2 immune response. The close gut-lung relationship has been described, however, the effect of gut-modulating agents such as probiotics in allergic airway disorder is unclear. Thus, the goal of this study was to evaluate theLimosilactobacillus fermentumsupplementation in animals with CARAS. Therefore, BALB/c mice were ovalbumin (OVA) -sensitized and -challenged after being supplemented withL. ferme...
Source: Immunobiology - August 2, 2023 Category: Allergy & Immunology Authors: Raquel F P Cavalcanti Francisco A A F Gadelha La ércia K D Paiva Ferreira Larissa A M Paiva Ferreira Jos é V Chaves Júnior Rayanne S de Ara újo Batista Taynara B L Melo F ábio S de Souza Adriano F Alves Le ônia Maria Batista Marcia R Piuvezam Source Type: research
Limosilactobacillus fermentum modulates the gut-airway axis by improving the immune response through FOXP3 activation on combined allergic rhinitis and asthma syndrome (CARAS)
Immunobiology. 2023 Jul 26;228(5):152721. doi: 10.1016/j.imbio.2023.152721. Online ahead of print.ABSTRACTCombined allergic rhinitis and asthma syndrome (CARAS) is an allergic airway inflammatory disorder orchestrated by the type 2 immune response. The close gut-lung relationship has been described, however, the effect of gut-modulating agents such as probiotics in allergic airway disorder is unclear. Thus, the goal of this study was to evaluate theLimosilactobacillus fermentumsupplementation in animals with CARAS. Therefore, BALB/c mice were ovalbumin (OVA) -sensitized and -challenged after being supplemented withL. ferme...
Source: Immunobiology - August 2, 2023 Category: Allergy & Immunology Authors: Raquel F P Cavalcanti Francisco A A F Gadelha La ércia K D Paiva Ferreira Larissa A M Paiva Ferreira Jos é V Chaves Júnior Rayanne S de Ara újo Batista Taynara B L Melo F ábio S de Souza Adriano F Alves Le ônia Maria Batista Marcia R Piuvezam Source Type: research
PD1 is transcriptionally regulated by LEF1 in mature T cells
Immunobiology. 2023 Jul 20;228(5):152708. doi: 10.1016/j.imbio.2023.152708. Online ahead of print.ABSTRACTThe role of programmed cell death 1 (PD1) in cancer immune evasion is of considerable importance, prompting the development of monoclonal antibodies that specifically target PD-1 to enhance the immune system for cancer therapy. Nevertheless, the efficacy of PD1/programmed cell death-Ligand 1 (PD-L1) blocking antibodies is limited to certain patients or tumor types. Although researchers have demonstrated the influence of PD-1 on the positive selection of T cells, its effect on the T-cell repertoire remains uncertain. Ly...
Source: Immunobiology - July 31, 2023 Category: Allergy & Immunology Authors: Pin Zhao Lanming Sun Cong Zhao Samiullah Malik Source Type: research
PD1 is transcriptionally regulated by LEF1 in mature T cells
Immunobiology. 2023 Jul 20;228(5):152708. doi: 10.1016/j.imbio.2023.152708. Online ahead of print.ABSTRACTThe role of programmed cell death 1 (PD1) in cancer immune evasion is of considerable importance, prompting the development of monoclonal antibodies that specifically target PD-1 to enhance the immune system for cancer therapy. Nevertheless, the efficacy of PD1/programmed cell death-Ligand 1 (PD-L1) blocking antibodies is limited to certain patients or tumor types. Although researchers have demonstrated the influence of PD-1 on the positive selection of T cells, its effect on the T-cell repertoire remains uncertain. Ly...
Source: Immunobiology - July 31, 2023 Category: Allergy & Immunology Authors: Pin Zhao Lanming Sun Cong Zhao Samiullah Malik Source Type: research
PD1 is transcriptionally regulated by LEF1 in mature T cells
Immunobiology. 2023 Jul 20;228(5):152708. doi: 10.1016/j.imbio.2023.152708. Online ahead of print.ABSTRACTThe role of programmed cell death 1 (PD1) in cancer immune evasion is of considerable importance, prompting the development of monoclonal antibodies that specifically target PD-1 to enhance the immune system for cancer therapy. Nevertheless, the efficacy of PD1/programmed cell death-Ligand 1 (PD-L1) blocking antibodies is limited to certain patients or tumor types. Although researchers have demonstrated the influence of PD-1 on the positive selection of T cells, its effect on the T-cell repertoire remains uncertain. Ly...
Source: Immunobiology - July 31, 2023 Category: Allergy & Immunology Authors: Pin Zhao Lanming Sun Cong Zhao Samiullah Malik Source Type: research
Identification and validation of ferroptosis-related prognostic risk model and immune landscape in hepatocellular carcinoma
CONCLUSION: Our study developed a prognostic risk model based on ferroptosis regulatory genes, which could accurately predict the patients' prognosis. Immune characteristics analysisrevealed that ferroptosis regulatory genes were associated with immune cells infiltration and immune checkpoints in HCC.PMID:37517112 | DOI:10.1016/j.imbio.2023.152723 (Source: Immunobiology)
Source: Immunobiology - July 30, 2023 Category: Allergy & Immunology Authors: Fei Tang Ning Wang Source Type: research
Lactobacillus rhamnosus 76 alleviates airway inflammation in ovalbumin-allergic mice and improves mucus secretion by down-regulating STAT6/SPDEF pathway
In conclusion, LR76 alleviated airway inflammation and Th2 response in OVA-allergic mice and improved the mucus secretion of mouse lung tissue and 16HBE cells in the asthma model by down-regulating STAT6/SPDEF pathway.PMID:37515878 | DOI:10.1016/j.imbio.2023.152712 (Source: Immunobiology)
Source: Immunobiology - July 29, 2023 Category: Allergy & Immunology Authors: Yangfan Hou Shuping Zheng Fan Zou Dan Wang Hongju Da Yong Zhou Xinping Fan Jianghao Liu Hongyan Zhao Jin He Hongxin Li Xiuzhen Sun Yun Liu Source Type: research
RNA-Seq and ATAC-Seq analyses reveal a global transcriptional and chromatin accessibility profiling of γδ T17 differentiation from mouse spleen
Immunobiology. 2023 Jul 5;228(5):152461. doi: 10.1016/j.imbio.2023.152461. Online ahead of print.ABSTRACTIL-17A-producing γδ T cells (γδ T17) are known to play important roles in various autoimmune diseases. However, the molecular mechanisms of γδ T17 differentiation and their functions have not been clarified yet. Here, we sorted IL-17A+ Vγ4, IL-17A- Vγ4, and Vγ1 subsets from mouse spleen by in vitro priming of γδ T17 cells and investigated their differentially expressed genes (DEGs) and differentially accessible regions (DARs) using RNA-seq and ATAC-seq, respectively. Our results showed that DEGs-1 (upregulate...
Source: Immunobiology - July 29, 2023 Category: Allergy & Immunology Authors: Nanxi Shi Yawen Zhang Yunting Liang Yiming Chen Yu Huang Xichun Xia Zonghua Liu Zhenhua Li Fang Huang Source Type: research
