Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort
CONCLUSION: In patients with type 2 diabetes and albuminuria, SGLT-2 inhibition resulted in modest C3 activation in plasma, likely not driven by primary changes in circulating collectins and not resulting in changes in membrane attack complex. Based on systemic analyses, organ-specific local protective effects of gliflozins against complement activation cannot be excluded.PMID:38518448 | DOI:10.1016/j.imbio.2024.152797 (Source: Immunobiology)
Source: Immunobiology - March 22, 2024 Category: Allergy & Immunology Authors: Mia Jensen Mie K Eickhoff Frederik Persson Peter Rossing Steffen Thiel S øren W K Hansen Yaseelan Palarasah Per Svenningsen Boye L Jensen Source Type: research
Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort
CONCLUSION: In patients with type 2 diabetes and albuminuria, SGLT-2 inhibition resulted in modest C3 activation in plasma, likely not driven by primary changes in circulating collectins and not resulting in changes in membrane attack complex. Based on systemic analyses, organ-specific local protective effects of gliflozins against complement activation cannot be excluded.PMID:38518448 | DOI:10.1016/j.imbio.2024.152797 (Source: Immunobiology)
Source: Immunobiology - March 22, 2024 Category: Allergy & Immunology Authors: Mia Jensen Mie K Eickhoff Frederik Persson Peter Rossing Steffen Thiel S øren W K Hansen Yaseelan Palarasah Per Svenningsen Boye L Jensen Source Type: research
Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort
CONCLUSION: In patients with type 2 diabetes and albuminuria, SGLT-2 inhibition resulted in modest C3 activation in plasma, likely not driven by primary changes in circulating collectins and not resulting in changes in membrane attack complex. Based on systemic analyses, organ-specific local protective effects of gliflozins against complement activation cannot be excluded.PMID:38518448 | DOI:10.1016/j.imbio.2024.152797 (Source: Immunobiology)
Source: Immunobiology - March 22, 2024 Category: Allergy & Immunology Authors: Mia Jensen Mie K Eickhoff Frederik Persson Peter Rossing Steffen Thiel S øren W K Hansen Yaseelan Palarasah Per Svenningsen Boye L Jensen Source Type: research
Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort
CONCLUSION: In patients with type 2 diabetes and albuminuria, SGLT-2 inhibition resulted in modest C3 activation in plasma, likely not driven by primary changes in circulating collectins and not resulting in changes in membrane attack complex. Based on systemic analyses, organ-specific local protective effects of gliflozins against complement activation cannot be excluded.PMID:38518448 | DOI:10.1016/j.imbio.2024.152797 (Source: Immunobiology)
Source: Immunobiology - March 22, 2024 Category: Allergy & Immunology Authors: Mia Jensen Mie K Eickhoff Frederik Persson Peter Rossing Steffen Thiel S øren W K Hansen Yaseelan Palarasah Per Svenningsen Boye L Jensen Source Type: research
Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort
CONCLUSION: In patients with type 2 diabetes and albuminuria, SGLT-2 inhibition resulted in modest C3 activation in plasma, likely not driven by primary changes in circulating collectins and not resulting in changes in membrane attack complex. Based on systemic analyses, organ-specific local protective effects of gliflozins against complement activation cannot be excluded.PMID:38518448 | DOI:10.1016/j.imbio.2024.152797 (Source: Immunobiology)
Source: Immunobiology - March 22, 2024 Category: Allergy & Immunology Authors: Mia Jensen Mie K Eickhoff Frederik Persson Peter Rossing Steffen Thiel S øren W K Hansen Yaseelan Palarasah Per Svenningsen Boye L Jensen Source Type: research
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis
CONCLUSION: This study suggests that the XIST-EZH2 interaction-mediated GABARAP inhibition activates caspase-11-dependent inflammatory injury in UC.PMID:38484431 | DOI:10.1016/j.imbio.2024.152796 (Source: Immunobiology)
Source: Immunobiology - March 14, 2024 Category: Allergy & Immunology Authors: Dan Gu Ting Cao Shijie Yi Xiaoqian Li Ya Liu Source Type: research
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis
CONCLUSION: This study suggests that the XIST-EZH2 interaction-mediated GABARAP inhibition activates caspase-11-dependent inflammatory injury in UC.PMID:38484431 | DOI:10.1016/j.imbio.2024.152796 (Source: Immunobiology)
Source: Immunobiology - March 14, 2024 Category: Allergy & Immunology Authors: Dan Gu Ting Cao Shijie Yi Xiaoqian Li Ya Liu Source Type: research
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis
CONCLUSION: This study suggests that the XIST-EZH2 interaction-mediated GABARAP inhibition activates caspase-11-dependent inflammatory injury in UC.PMID:38484431 | DOI:10.1016/j.imbio.2024.152796 (Source: Immunobiology)
Source: Immunobiology - March 14, 2024 Category: Allergy & Immunology Authors: Dan Gu Ting Cao Shijie Yi Xiaoqian Li Ya Liu Source Type: research
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis
CONCLUSION: This study suggests that the XIST-EZH2 interaction-mediated GABARAP inhibition activates caspase-11-dependent inflammatory injury in UC.PMID:38484431 | DOI:10.1016/j.imbio.2024.152796 (Source: Immunobiology)
Source: Immunobiology - March 14, 2024 Category: Allergy & Immunology Authors: Dan Gu Ting Cao Shijie Yi Xiaoqian Li Ya Liu Source Type: research
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis
CONCLUSION: This study suggests that the XIST-EZH2 interaction-mediated GABARAP inhibition activates caspase-11-dependent inflammatory injury in UC.PMID:38484431 | DOI:10.1016/j.imbio.2024.152796 (Source: Immunobiology)
Source: Immunobiology - March 14, 2024 Category: Allergy & Immunology Authors: Dan Gu Ting Cao Shijie Yi Xiaoqian Li Ya Liu Source Type: research
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis
CONCLUSION: This study suggests that the XIST-EZH2 interaction-mediated GABARAP inhibition activates caspase-11-dependent inflammatory injury in UC.PMID:38484431 | DOI:10.1016/j.imbio.2024.152796 (Source: Immunobiology)
Source: Immunobiology - March 14, 2024 Category: Allergy & Immunology Authors: Dan Gu Ting Cao Shijie Yi Xiaoqian Li Ya Liu Source Type: research
The predictive value of miR-377 and phospholipase A2 in the early diagnosis of diabetic kidney disease and their relationship with inflammatory factors
CONCLUSION: miR-377 and phospholipase A2 have good diagnostic efficiency for the early diagnosis of diabetic kidney disease. They can be used as early biomarkers.miR-377 and phospholipase A2 were positively correlated with inflammatory factors and involved in the occurrence and development of diabetic kidney disease.PMID:38401467 | DOI:10.1016/j.imbio.2024.152792 (Source: Immunobiology)
Source: Immunobiology - February 24, 2024 Category: Allergy & Immunology Authors: Chenhao Xing Lijing Huo Hongyue Tang Yamin Lu Guangxia Liu Fang Chen Zhan Hou Source Type: research
The predictive value of miR-377 and phospholipase A2 in the early diagnosis of diabetic kidney disease and their relationship with inflammatory factors
CONCLUSION: miR-377 and phospholipase A2 have good diagnostic efficiency for the early diagnosis of diabetic kidney disease. They can be used as early biomarkers.miR-377 and phospholipase A2 were positively correlated with inflammatory factors and involved in the occurrence and development of diabetic kidney disease.PMID:38401467 | DOI:10.1016/j.imbio.2024.152792 (Source: Immunobiology)
Source: Immunobiology - February 24, 2024 Category: Allergy & Immunology Authors: Chenhao Xing Lijing Huo Hongyue Tang Yamin Lu Guangxia Liu Fang Chen Zhan Hou Source Type: research
The predictive value of miR-377 and phospholipase A2 in the early diagnosis of diabetic kidney disease and their relationship with inflammatory factors
CONCLUSION: miR-377 and phospholipase A2 have good diagnostic efficiency for the early diagnosis of diabetic kidney disease. They can be used as early biomarkers.miR-377 and phospholipase A2 were positively correlated with inflammatory factors and involved in the occurrence and development of diabetic kidney disease.PMID:38401467 | DOI:10.1016/j.imbio.2024.152792 (Source: Immunobiology)
Source: Immunobiology - February 24, 2024 Category: Allergy & Immunology Authors: Chenhao Xing Lijing Huo Hongyue Tang Yamin Lu Guangxia Liu Fang Chen Zhan Hou Source Type: research
The predictive value of miR-377 and phospholipase A2 in the early diagnosis of diabetic kidney disease and their relationship with inflammatory factors
CONCLUSION: miR-377 and phospholipase A2 have good diagnostic efficiency for the early diagnosis of diabetic kidney disease. They can be used as early biomarkers.miR-377 and phospholipase A2 were positively correlated with inflammatory factors and involved in the occurrence and development of diabetic kidney disease.PMID:38401467 | DOI:10.1016/j.imbio.2024.152792 (Source: Immunobiology)
Source: Immunobiology - February 24, 2024 Category: Allergy & Immunology Authors: Chenhao Xing Lijing Huo Hongyue Tang Yamin Lu Guangxia Liu Fang Chen Zhan Hou Source Type: research
