Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort

CONCLUSION: In patients with type 2 diabetes and albuminuria, SGLT-2 inhibition resulted in modest C3 activation in plasma, likely not driven by primary changes in circulating collectins and not resulting in changes in membrane attack complex. Based on systemic analyses, organ-specific local protective effects of gliflozins against complement activation cannot be excluded.PMID:38518448 | DOI:10.1016/j.imbio.2024.152797

Source: Immunobiology - March 22, 2024 Category: Allergy & Immunology Authors: Mia Jensen Mie K Eickhoff Frederik Persson Peter Rossing Steffen Thiel S øren W K Hansen Yaseelan Palarasah Per Svenningsen Boye L Jensen Source Type: research