PLEKHA4 promotes glioblastoma progression through apoptosis inhibition, tumor cell migration, and macrophage infiltration
CONCLUSION: Our findings highlight the pivotal role of PLEKHA4 in GBM pathogenesis and suggest its potential as a diagnostic and therapeutic target for GBM.PMID:37980830 | DOI:10.1016/j.imbio.2023.152746 (Source: Immunobiology)
Source: Immunobiology - November 19, 2023 Category: Allergy & Immunology Authors: Yang He Wenjing Zheng Yi Huo Longqi Sa Han Zhang Guangbin He Panfeng Shang Source Type: research
PLEKHA4 promotes glioblastoma progression through apoptosis inhibition, tumor cell migration, and macrophage infiltration
CONCLUSION: Our findings highlight the pivotal role of PLEKHA4 in GBM pathogenesis and suggest its potential as a diagnostic and therapeutic target for GBM.PMID:37980830 | DOI:10.1016/j.imbio.2023.152746 (Source: Immunobiology)
Source: Immunobiology - November 19, 2023 Category: Allergy & Immunology Authors: Yang He Wenjing Zheng Yi Huo Longqi Sa Han Zhang Guangbin He Panfeng Shang Source Type: research
PLEKHA4 promotes glioblastoma progression through apoptosis inhibition, tumor cell migration, and macrophage infiltration
CONCLUSION: Our findings highlight the pivotal role of PLEKHA4 in GBM pathogenesis and suggest its potential as a diagnostic and therapeutic target for GBM.PMID:37980830 | DOI:10.1016/j.imbio.2023.152746 (Source: Immunobiology)
Source: Immunobiology - November 19, 2023 Category: Allergy & Immunology Authors: Yang He Wenjing Zheng Yi Huo Longqi Sa Han Zhang Guangbin He Panfeng Shang Source Type: research
Human macrophage immunometabolism regulator (MACIR) in patients with periodontitis
CONCLUSION: The results of the study suggest that MACIR is an important regulator of the inflammatory process in patients with periodontitis. Decreased expression of the MACIR gene may activate macrophages to secrete mediators that increase inflammation and cause periodontal tissue destruction.PMID:37976770 | DOI:10.1016/j.imbio.2023.152760 (Source: Immunobiology)
Source: Immunobiology - November 17, 2023 Category: Allergy & Immunology Authors: Karol Serwin Ma łgorzata Kozak Ma łgorzata Mazurek-Mochol Katarzyna Piotrowska Micha ł Czerewaty Andrzej Pawlik Source Type: research
Human macrophage immunometabolism regulator (MACIR) in patients with periodontitis
CONCLUSION: The results of the study suggest that MACIR is an important regulator of the inflammatory process in patients with periodontitis. Decreased expression of the MACIR gene may activate macrophages to secrete mediators that increase inflammation and cause periodontal tissue destruction.PMID:37976770 | DOI:10.1016/j.imbio.2023.152760 (Source: Immunobiology)
Source: Immunobiology - November 17, 2023 Category: Allergy & Immunology Authors: Karol Serwin Ma łgorzata Kozak Ma łgorzata Mazurek-Mochol Katarzyna Piotrowska Micha ł Czerewaty Andrzej Pawlik Source Type: research
Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome
In this study, we investigated the effects of CAMKMT on caspase-11 non-canonical inflammasomes. CAMKMT expression levels were significantly decreased during inflammatory responses activated by caspase-11 non-canonical inflammasome in macrophages. Moreover, CaM lysine trimethylation was markedly inhibited, but no change was observed in CaM expression during these inflammatory responses in macrophages. Activation of the CaM downstream effectors, CaM-dependent proteinkinase kinase 2 and CaM-dependent proteinkinase type IV, was also inhibited during inflammatory responses activated by caspase-11 non-canonical inflammasome in m...
Source: Immunobiology - November 10, 2023 Category: Allergy & Immunology Authors: Hui-Jin Cho Dong Joon Lee Young-Su Yi Source Type: research
Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome
In this study, we investigated the effects of CAMKMT on caspase-11 non-canonical inflammasomes. CAMKMT expression levels were significantly decreased during inflammatory responses activated by caspase-11 non-canonical inflammasome in macrophages. Moreover, CaM lysine trimethylation was markedly inhibited, but no change was observed in CaM expression during these inflammatory responses in macrophages. Activation of the CaM downstream effectors, CaM-dependent proteinkinase kinase 2 and CaM-dependent proteinkinase type IV, was also inhibited during inflammatory responses activated by caspase-11 non-canonical inflammasome in m...
Source: Immunobiology - November 10, 2023 Category: Allergy & Immunology Authors: Hui-Jin Cho Dong Joon Lee Young-Su Yi Source Type: research
Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome
In this study, we investigated the effects of CAMKMT on caspase-11 non-canonical inflammasomes. CAMKMT expression levels were significantly decreased during inflammatory responses activated by caspase-11 non-canonical inflammasome in macrophages. Moreover, CaM lysine trimethylation was markedly inhibited, but no change was observed in CaM expression during these inflammatory responses in macrophages. Activation of the CaM downstream effectors, CaM-dependent proteinkinase kinase 2 and CaM-dependent proteinkinase type IV, was also inhibited during inflammatory responses activated by caspase-11 non-canonical inflammasome in m...
Source: Immunobiology - November 10, 2023 Category: Allergy & Immunology Authors: Hui-Jin Cho Dong Joon Lee Young-Su Yi Source Type: research
Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome
In this study, we investigated the effects of CAMKMT on caspase-11 non-canonical inflammasomes. CAMKMT expression levels were significantly decreased during inflammatory responses activated by caspase-11 non-canonical inflammasome in macrophages. Moreover, CaM lysine trimethylation was markedly inhibited, but no change was observed in CaM expression during these inflammatory responses in macrophages. Activation of the CaM downstream effectors, CaM-dependent proteinkinase kinase 2 and CaM-dependent proteinkinase type IV, was also inhibited during inflammatory responses activated by caspase-11 non-canonical inflammasome in m...
Source: Immunobiology - November 10, 2023 Category: Allergy & Immunology Authors: Hui-Jin Cho Dong Joon Lee Young-Su Yi Source Type: research
Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome
In this study, we investigated the effects of CAMKMT on caspase-11 non-canonical inflammasomes. CAMKMT expression levels were significantly decreased during inflammatory responses activated by caspase-11 non-canonical inflammasome in macrophages. Moreover, CaM lysine trimethylation was markedly inhibited, but no change was observed in CaM expression during these inflammatory responses in macrophages. Activation of the CaM downstream effectors, CaM-dependent proteinkinase kinase 2 and CaM-dependent proteinkinase type IV, was also inhibited during inflammatory responses activated by caspase-11 non-canonical inflammasome in m...
Source: Immunobiology - November 10, 2023 Category: Allergy & Immunology Authors: Hui-Jin Cho Dong Joon Lee Young-Su Yi Source Type: research
Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome
In this study, we investigated the effects of CAMKMT on caspase-11 non-canonical inflammasomes. CAMKMT expression levels were significantly decreased during inflammatory responses activated by caspase-11 non-canonical inflammasome in macrophages. Moreover, CaM lysine trimethylation was markedly inhibited, but no change was observed in CaM expression during these inflammatory responses in macrophages. Activation of the CaM downstream effectors, CaM-dependent proteinkinase kinase 2 and CaM-dependent proteinkinase type IV, was also inhibited during inflammatory responses activated by caspase-11 non-canonical inflammasome in m...
Source: Immunobiology - November 10, 2023 Category: Allergy & Immunology Authors: Hui-Jin Cho Dong Joon Lee Young-Su Yi Source Type: research
IL-27p28 specifically regulates MHC II expression in macrophages through CIITA
In this study, we used IL-27p28 conditional knock-out mice to investigate the regulatory effects of IL-27p28 on macrophage polarization and the expression of MHC II in macrophages. We found that MHC II expression was upregulated in the bone marrow-derived and peritoneal exudate macrophages (BMDMs; PEMs) from IL-27p28-deficient mice, with their inflammation regulating function unaffected. We also demonstrated that in the APCs, IL-27p28 selectively regulated MHC II expression in macrophages but not in dendritic cells. During Pseudomonas aeruginosa (P. aeruginosa) reinfection, higher survival rate, bacterial clearance, and ra...
Source: Immunobiology - November 9, 2023 Category: Allergy & Immunology Authors: Yu Han Xu Zhang Qing Wang Xiaoyue Cui Hesuiyuan Wang Xiang Zhang Qian Wang Jianbin Ji Yuebing Wang Shusen Wang Xiuming Zhang Haijin Xu Mingqiang Qiao Zhenzhou Wu Source Type: research
IL-27p28 specifically regulates MHC II expression in macrophages through CIITA
In this study, we used IL-27p28 conditional knock-out mice to investigate the regulatory effects of IL-27p28 on macrophage polarization and the expression of MHC II in macrophages. We found that MHC II expression was upregulated in the bone marrow-derived and peritoneal exudate macrophages (BMDMs; PEMs) from IL-27p28-deficient mice, with their inflammation regulating function unaffected. We also demonstrated that in the APCs, IL-27p28 selectively regulated MHC II expression in macrophages but not in dendritic cells. During Pseudomonas aeruginosa (P. aeruginosa) reinfection, higher survival rate, bacterial clearance, and ra...
Source: Immunobiology - November 9, 2023 Category: Allergy & Immunology Authors: Yu Han Xu Zhang Qing Wang Xiaoyue Cui Hesuiyuan Wang Xiang Zhang Qian Wang Jianbin Ji Yuebing Wang Shusen Wang Xiuming Zhang Haijin Xu Mingqiang Qiao Zhenzhou Wu Source Type: research
The signature and predictive value of immune parameters in patients with secondary hemophagocytic lymphohistiocytosis
CONCLUSION: The evaluation of immunological markers has critical value for selecting prognostic markers and potential treatment target among adults with sHLH.PMID:37939638 | DOI:10.1016/j.imbio.2023.152759 (Source: Immunobiology)
Source: Immunobiology - November 8, 2023 Category: Allergy & Immunology Authors: Huan Bai Yun Wang Ling Shen Ying Luo Guoxing Tang Feng Wang Ziyong Sun Hongyan Hou Source Type: research
Identification of hub biomarkers and immune-related pathways participating in the progression of Kawasaki disease by integrated bioinformatics analysis
CONCLUSION: Activated dendritic cells, neutrophils, and macrophages were closely associated with the pathogenesis of KD. Furthermore, the hub genes (S100A12, MMP9, TLR2, NLRC4, and ARG1) are likely to participate in the pathogenic mechanisms of KD through immune-related signaling pathways.PMID:37837870 | DOI:10.1016/j.imbio.2023.152750 (Source: Immunobiology)
Source: Immunobiology - October 14, 2023 Category: Allergy & Immunology Authors: Yang Gao Xuan Tang Guanghui Qian Hongbiao Huang Nana Wang Yan Wang Wenyu Zhuo Jiaqi Jiang Yiming Zheng Wenjie Li Zhiheng Liu Xuan Li Lei Xu Jiaying Zhang Li Huang Ying Liu Haitao Lv Source Type: research
