The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion
CONCLUSION: The present results unveiled that the macrophage phenotype was inclined to be present in a hybridity state of four M2 sub-phenotypes and the genes related to tumor-promoting, pro-inflammation and pro-fibrosis were not increased after MSCs injection.PMID:38309141 | DOI:10.1016/j.imbio.2024.152788 (Source: Immunobiology)
Source: Immunobiology - February 3, 2024 Category: Allergy & Immunology Authors: Wanlu Su Yaqi Yin Yu Cheng Songyan Yu Ruofan Hu Haixia Zhang Jia Hu Rui Ren Yue Zhang Jian Zhao Anning Wang Zhaohui Lyu Yiming Mu Jieqing Gao Source Type: research
Evaluation of the serum levels of CCL2, CCL3, and IL-29 after first and second administrations of the COVID-19 vaccine (Oxford-AstraZeneca)
CONCLUSIONS: Oxford-AstraZeneca COVID-19 vaccine is able to induce inflammatory CCL2 and CCL3 chemokines as well as protective interferon lambda (IL-29).PMID:38290406 | DOI:10.1016/j.imbio.2024.152789 (Source: Immunobiology)
Source: Immunobiology - January 30, 2024 Category: Allergy & Immunology Authors: Zahra Bagheri-Hosseinabadi Ayat Kaeidi Mahdi Rezvani Gholamhossein Taghipour Khaje Sharifi Mitra Abbasifard Source Type: research
Hyperglycemia modulates M1/M2 macrophage polarization in chronic diabetic patients with pulmonary tuberculosis infection
Immunobiology. 2024 Jan 14;229(2):152787. doi: 10.1016/j.imbio.2024.152787. Online ahead of print.ABSTRACTIncreased susceptibility to bacterial infections like tuberculosis (TB) is one of the complications of type 2 diabetes, however the underlying mechanisms remains poorly characterized. To explore how chronic hyperglycemia in diabetes affects progression of active TB, we examined mRNA expression of M1 (proinflammatory) and M2 (anti-inflammatory) cytokines/markers, in monocyte-derived macrophages obtained from patients with PTB + DM (pulmonary TB + diabetes mellitus type 2), patients with DM alone, patients with PTB alone...
Source: Immunobiology - January 25, 2024 Category: Allergy & Immunology Authors: Sudhasini Panda Alisha Arora Kalpana Luthra Anant Mohan Naval K Vikram Neeraj Kumar Gupta Archana Singh Source Type: research
Clinical relevance of ORCs in predicting prognosis and immunotherapy outcomes: A pan-cancer analysis
CONCLUSIONS: Our research elucidates the genomic changes associated with and clinical relevance of ORCs in cancer and provides unique insights for future investigation of ORCs in immunotherapy.PMID:38211410 | DOI:10.1016/j.imbio.2024.152783 (Source: Immunobiology)
Source: Immunobiology - January 11, 2024 Category: Allergy & Immunology Authors: Yajun Zhao Jiangtao Wang Xiaodong Liang Chen Wang Source Type: research
Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen
In this study, we detected MANF expression in spleen tissues and found that MANF was expressed in the red pulp and marginal zone. Additionally, MANF was localized in the CD68+ and CD138+ cells of adult rat spleen tissues, but not in the CD3+ cells. We performed immunohistochemical staining to detect MANF expression in the spleen tissues of rats that were different ages, and we found that MANF+ cells were localized together in the spleen tissues of rats that were 1-4 weeks old. MANF was also expressed in CD68+ cells in the spleen tissues of rats and mice. Furthermore, we found that MANF deficiency inhibited white pulp devel...
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Chengyue Zhou Dan Han Hui Fang Dake Huang Heping Cai Yujun Shen Yuxian Shen Jun Liu Source Type: research
Toll-like receptor expression and functional behavior in platelets from patients with systemic lupus erythematosus
CONCLUSION: Our study demonstrates normal platelet TLR expression and function together with increased circulating platelet-monocyte aggregates. In addition, a direct correlation was observed between plasma HMGB1 levels and platelet vWf release following TLR2 stimulation. This platelet behavior in a group of patients undergoing HCQ treatment suggests that platelets could play a role in the inflammatory state of SLE.PMID:38159527 | DOI:10.1016/j.imbio.2023.152782 (Source: Immunobiology)
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Mar ía C Baroni Pietto Ana C Glembotsky Paola R Lev Cecilia R Mar ín Oyarzún Geraldine De Luca Graciela Gomez Mar ía V Collado Nancy Char ó Adela S Cellucci Paula G Heller Nora P Goette Rosana F Marta Source Type: research
Engagement of CD300c by a novel monoclonal antibody induces the differentiation of monocytes to M1 macrophages
Immunobiology. 2024 Jan;229(1):152780. doi: 10.1016/j.imbio.2023.152780. Epub 2023 Dec 21.ABSTRACTHuman CD300c is expressed on various immune or cancer cells and is a novel B7 family member, functioning as an activity modulator on immune cells. To elucidate the function of CD300c, we developed CL7, a human CD300c-specific monoclonal antibody, and assessed its biological activity. The specific binding of CL7 monoclonal antibody against recombinant CD300c antigen was confirmed using enzyme-linked immunosorbent assay and surface plasmon resonance analysis. The binding affinity of CL7 was strong at the sub-nanomolar level. Fur...
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Su In Lee Haneul Kim Chang Ki Lim Jae Dong Kim Jeong Seok Heo Joongoo Jung Chan Kim Hong Jae Chon Jae-Won Jeon Source Type: research
Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen
In this study, we detected MANF expression in spleen tissues and found that MANF was expressed in the red pulp and marginal zone. Additionally, MANF was localized in the CD68+ and CD138+ cells of adult rat spleen tissues, but not in the CD3+ cells. We performed immunohistochemical staining to detect MANF expression in the spleen tissues of rats that were different ages, and we found that MANF+ cells were localized together in the spleen tissues of rats that were 1-4 weeks old. MANF was also expressed in CD68+ cells in the spleen tissues of rats and mice. Furthermore, we found that MANF deficiency inhibited white pulp devel...
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Chengyue Zhou Dan Han Hui Fang Dake Huang Heping Cai Yujun Shen Yuxian Shen Jun Liu Source Type: research
Toll-like receptor expression and functional behavior in platelets from patients with systemic lupus erythematosus
CONCLUSION: Our study demonstrates normal platelet TLR expression and function together with increased circulating platelet-monocyte aggregates. In addition, a direct correlation was observed between plasma HMGB1 levels and platelet vWf release following TLR2 stimulation. This platelet behavior in a group of patients undergoing HCQ treatment suggests that platelets could play a role in the inflammatory state of SLE.PMID:38159527 | DOI:10.1016/j.imbio.2023.152782 (Source: Immunobiology)
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Mar ía C Baroni Pietto Ana C Glembotsky Paola R Lev Cecilia R Mar ín Oyarzún Geraldine De Luca Graciela Gomez Mar ía V Collado Nancy Char ó Adela S Cellucci Paula G Heller Nora P Goette Rosana F Marta Source Type: research
Engagement of CD300c by a novel monoclonal antibody induces the differentiation of monocytes to M1 macrophages
Immunobiology. 2023 Dec 21;229(1):152780. doi: 10.1016/j.imbio.2023.152780. Online ahead of print.ABSTRACTHuman CD300c is expressed on various immune or cancer cells and is a novel B7 family member, functioning as an activity modulator on immune cells. To elucidate the function of CD300c, we developed CL7, a human CD300c-specific monoclonal antibody, and assessed its biological activity. The specific binding of CL7 monoclonal antibody against recombinant CD300c antigen was confirmed using enzyme-linked immunosorbent assay and surface plasmon resonance analysis. The binding affinity of CL7 was strong at the sub-nanomolar le...
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Su In Lee Haneul Kim Chang Ki Lim Jae Dong Kim Jeong Seok Heo Joongoo Jung Chan Kim Hong Jae Chon Jae-Won Jeon Source Type: research
Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen
In this study, we detected MANF expression in spleen tissues and found that MANF was expressed in the red pulp and marginal zone. Additionally, MANF was localized in the CD68+ and CD138+ cells of adult rat spleen tissues, but not in the CD3+ cells. We performed immunohistochemical staining to detect MANF expression in the spleen tissues of rats that were different ages, and we found that MANF+ cells were localized together in the spleen tissues of rats that were 1-4 weeks old. MANF was also expressed in CD68+ cells in the spleen tissues of rats and mice. Furthermore, we found that MANF deficiency inhibited white pulp devel...
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Chengyue Zhou Dan Han Hui Fang Dake Huang Heping Cai Yujun Shen Yuxian Shen Jun Liu Source Type: research
Toll-like receptor expression and functional behavior in platelets from patients with systemic lupus erythematosus
CONCLUSION: Our study demonstrates normal platelet TLR expression and function together with increased circulating platelet-monocyte aggregates. In addition, a direct correlation was observed between plasma HMGB1 levels and platelet vWf release following TLR2 stimulation. This platelet behavior in a group of patients undergoing HCQ treatment suggests that platelets could play a role in the inflammatory state of SLE.PMID:38159527 | DOI:10.1016/j.imbio.2023.152782 (Source: Immunobiology)
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Mar ía C Baroni Pietto Ana C Glembotsky Paola R Lev Cecilia R Mar ín Oyarzún Geraldine De Luca Graciela Gomez Mar ía V Collado Nancy Char ó Adela S Cellucci Paula G Heller Nora P Goette Rosana F Marta Source Type: research
Engagement of CD300c by a novel monoclonal antibody induces the differentiation of monocytes to M1 macrophages
Immunobiology. 2023 Dec 21;229(1):152780. doi: 10.1016/j.imbio.2023.152780. Online ahead of print.ABSTRACTHuman CD300c is expressed on various immune or cancer cells and is a novel B7 family member, functioning as an activity modulator on immune cells. To elucidate the function of CD300c, we developed CL7, a human CD300c-specific monoclonal antibody, and assessed its biological activity. The specific binding of CL7 monoclonal antibody against recombinant CD300c antigen was confirmed using enzyme-linked immunosorbent assay and surface plasmon resonance analysis. The binding affinity of CL7 was strong at the sub-nanomolar le...
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Su In Lee Haneul Kim Chang Ki Lim Jae Dong Kim Jeong Seok Heo Joongoo Jung Chan Kim Hong Jae Chon Jae-Won Jeon Source Type: research
Deletion of mesencephalic astrocyte-derived neurotrophic factor delays and damages the development of white pulp in spleen
In this study, we detected MANF expression in spleen tissues and found that MANF was expressed in the red pulp and marginal zone. Additionally, MANF was localized in the CD68+ and CD138+ cells of adult rat spleen tissues, but not in the CD3+ cells. We performed immunohistochemical staining to detect MANF expression in the spleen tissues of rats that were different ages, and we found that MANF+ cells were localized together in the spleen tissues of rats that were 1-4 weeks old. MANF was also expressed in CD68+ cells in the spleen tissues of rats and mice. Furthermore, we found that MANF deficiency inhibited white pulp devel...
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Chengyue Zhou Dan Han Hui Fang Dake Huang Heping Cai Yujun Shen Yuxian Shen Jun Liu Source Type: research
Toll-like receptor expression and functional behavior in platelets from patients with systemic lupus erythematosus
CONCLUSION: Our study demonstrates normal platelet TLR expression and function together with increased circulating platelet-monocyte aggregates. In addition, a direct correlation was observed between plasma HMGB1 levels and platelet vWf release following TLR2 stimulation. This platelet behavior in a group of patients undergoing HCQ treatment suggests that platelets could play a role in the inflammatory state of SLE.PMID:38159527 | DOI:10.1016/j.imbio.2023.152782 (Source: Immunobiology)
Source: Immunobiology - December 30, 2023 Category: Allergy & Immunology Authors: Mar ía C Baroni Pietto Ana C Glembotsky Paola R Lev Cecilia R Mar ín Oyarzún Geraldine De Luca Graciela Gomez Mar ía V Collado Nancy Char ó Adela S Cellucci Paula G Heller Nora P Goette Rosana F Marta Source Type: research
