Exploration of complement split products in plasma and urine as biomarkers of kidney graft rejection
CONCLUSION: This study shows increased plasma C3a and C3dg in kidney transplant recipients, primarily with T cell mediated rejection. This finding suggests that consecutive measurements of C3a and C3dg in plasma could be applicable to monitor alloreactivity in kidney transplant recipients. Urine complement split products are unsuitable as rejection biomarkers since the permeability of the glomerular filtration barrier strongly influences them. Prospective longitudinal studies on plasma C3a and C3dg dynamics will be needed to validate present findings.PMID:37406469 | DOI:10.1016/j.imbio.2023.152462 (Source: Immunobiology)
Source: Immunobiology - July 5, 2023 Category: Allergy & Immunology Authors: Ann-Maria Gramkow Gustaf L Isaksson Yaseelan Palarasah Boye L Jensen Anne Alnor Helle C Thiesson Source Type: research
Exploration of complement split products in plasma and urine as biomarkers of kidney graft rejection
CONCLUSION: This study shows increased plasma C3a and C3dg in kidney transplant recipients, primarily with T cell mediated rejection. This finding suggests that consecutive measurements of C3a and C3dg in plasma could be applicable to monitor alloreactivity in kidney transplant recipients. Urine complement split products are unsuitable as rejection biomarkers since the permeability of the glomerular filtration barrier strongly influences them. Prospective longitudinal studies on plasma C3a and C3dg dynamics will be needed to validate present findings.PMID:37406469 | DOI:10.1016/j.imbio.2023.152462 (Source: Immunobiology)
Source: Immunobiology - July 5, 2023 Category: Allergy & Immunology Authors: Ann-Maria Gramkow Gustaf L Isaksson Yaseelan Palarasah Boye L Jensen Anne Alnor Helle C Thiesson Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
Lactobacillus rhamnosus reduces CD8 < sup > + < /sup > T cell mediated inflammation in patients with rheumatoid arthritis
CONCLUSIONS: Thus, we conclude that L. rhamnosus can effectively suppress CD8+T cell mediated inflammation by a simultaneous decrease of Th1 cells that may potentiate better treatment modalities for RA.PMID:37356231 | DOI:10.1016/j.imbio.2023.152415 (Source: Immunobiology)
Source: Immunobiology - June 25, 2023 Category: Allergy & Immunology Authors: Archana Tripathy Nitish Swain Prasanta Padhan Sunil K Raghav Bhawna Gupta Source Type: research
ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm
Immunobiology. 2023 Jun 8;228(4):152412. doi: 10.1016/j.imbio.2023.152412. Online ahead of print.ABSTRACTSepsis is a life-threatening systemic organ dysfunction caused by the host's unregulated response to a widespread bacterial infection. Endothelial injury is a major pathophysiologic symptom of sepsis and is considered a critical factor in promoting the progression of disease severity. ELAV like RNA binding protein 1(ELAVL1) is a ubiquitously expressed RNA-binding protein that may play an important role during sepsis. Nonetheless, the molecular mechanisms of ELAVL1 on endothelial cell damage in sepsis have not been well ...
Source: Immunobiology - June 21, 2023 Category: Allergy & Immunology Authors: Chaoyang Zhou Yacan Luo Zhengwei Huang Fubo Dong Junliang Lin Liwen Luo Xi Li Chang Cai Wenzhi Wu Source Type: research
ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm
Immunobiology. 2023 Jun 8;228(4):152412. doi: 10.1016/j.imbio.2023.152412. Online ahead of print.ABSTRACTSepsis is a life-threatening systemic organ dysfunction caused by the host's unregulated response to a widespread bacterial infection. Endothelial injury is a major pathophysiologic symptom of sepsis and is considered a critical factor in promoting the progression of disease severity. ELAV like RNA binding protein 1(ELAVL1) is a ubiquitously expressed RNA-binding protein that may play an important role during sepsis. Nonetheless, the molecular mechanisms of ELAVL1 on endothelial cell damage in sepsis have not been well ...
Source: Immunobiology - June 21, 2023 Category: Allergy & Immunology Authors: Chaoyang Zhou Yacan Luo Zhengwei Huang Fubo Dong Junliang Lin Liwen Luo Xi Li Chang Cai Wenzhi Wu Source Type: research
ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm
Immunobiology. 2023 Jun 8;228(4):152412. doi: 10.1016/j.imbio.2023.152412. Online ahead of print.ABSTRACTSepsis is a life-threatening systemic organ dysfunction caused by the host's unregulated response to a widespread bacterial infection. Endothelial injury is a major pathophysiologic symptom of sepsis and is considered a critical factor in promoting the progression of disease severity. ELAV like RNA binding protein 1(ELAVL1) is a ubiquitously expressed RNA-binding protein that may play an important role during sepsis. Nonetheless, the molecular mechanisms of ELAVL1 on endothelial cell damage in sepsis have not been well ...
Source: Immunobiology - June 21, 2023 Category: Allergy & Immunology Authors: Chaoyang Zhou Yacan Luo Zhengwei Huang Fubo Dong Junliang Lin Liwen Luo Xi Li Chang Cai Wenzhi Wu Source Type: research
ELAVL1 promotes LPS-induced endothelial cells injury through modulation of cytokine storm
Immunobiology. 2023 Jun 8;228(4):152412. doi: 10.1016/j.imbio.2023.152412. Online ahead of print.ABSTRACTSepsis is a life-threatening systemic organ dysfunction caused by the host's unregulated response to a widespread bacterial infection. Endothelial injury is a major pathophysiologic symptom of sepsis and is considered a critical factor in promoting the progression of disease severity. ELAV like RNA binding protein 1(ELAVL1) is a ubiquitously expressed RNA-binding protein that may play an important role during sepsis. Nonetheless, the molecular mechanisms of ELAVL1 on endothelial cell damage in sepsis have not been well ...
Source: Immunobiology - June 21, 2023 Category: Allergy & Immunology Authors: Chaoyang Zhou Yacan Luo Zhengwei Huang Fubo Dong Junliang Lin Liwen Luo Xi Li Chang Cai Wenzhi Wu Source Type: research
Remembering the late Prof Robert B. Sim: Memorial Symposium and a Special issue of Immunobiology
Immunobiology. 2023 Jun 1:152400. doi: 10.1016/j.imbio.2023.152400. Online ahead of print.NO ABSTRACTPMID:37331913 | DOI:10.1016/j.imbio.2023.152400 (Source: Immunobiology)
Source: Immunobiology - June 18, 2023 Category: Allergy & Immunology Authors: Uday Kishore Mohammed R Daha Kenneth B M Reid Source Type: research
