Metabolomic and proteomic analyses of primary Sjogren's syndrome
In this study, the progression mechanism of pSS was analyzed and novel biomarkers were identified by proteomics and metabolomics.PMID:37567091 | DOI:10.1016/j.imbio.2023.152722 (Source: Immunobiology)
Source: Immunobiology - August 11, 2023 Category: Allergy & Immunology Authors: Junning Zhang Zixing Tang Zhenyu Liu Guangyu Wang Xueli Yang Xianliang Hou Source Type: research

Metabolomic and proteomic analyses of primary Sjogren's syndrome
In this study, the progression mechanism of pSS was analyzed and novel biomarkers were identified by proteomics and metabolomics.PMID:37567091 | DOI:10.1016/j.imbio.2023.152722 (Source: Immunobiology)
Source: Immunobiology - August 11, 2023 Category: Allergy & Immunology Authors: Junning Zhang Zixing Tang Zhenyu Liu Guangyu Wang Xueli Yang Xianliang Hou Source Type: research

TLR-2 agonist Pam3CSK4 has no therapeutic effect on visceral leishmaniasis in BALB/c mice and may enhance the pathogenesis of the disease
In this study, TLR-2 agonist Pam3CSK4 showed no therapeutic effect on visceral leishmaniasis in BALB/c mice and might enhance the pathogenesis of the disease possibly due to the down-regulation of several immune-related pathways, which can improve our understanding of the role of TLR-2 in both treatment and vaccine development.PMID:37562277 | DOI:10.1016/j.imbio.2023.152725 (Source: Immunobiology)
Source: Immunobiology - August 10, 2023 Category: Allergy & Immunology Authors: Xuechun Liao Jinlei He Ruanyan Wang Jianhui Zhang Shulan Wei Yuying Xiao Qi Zhou Xiaoting Zheng Zheying Zhu Zhiwan Zheng Jiao Li Zheng Zeng Dali Chen Jianping Chen Source Type: research

TLR-2 agonist Pam3CSK4 has no therapeutic effect on visceral leishmaniasis in BALB/c mice and may enhance the pathogenesis of the disease
In this study, TLR-2 agonist Pam3CSK4 showed no therapeutic effect on visceral leishmaniasis in BALB/c mice and might enhance the pathogenesis of the disease possibly due to the down-regulation of several immune-related pathways, which can improve our understanding of the role of TLR-2 in both treatment and vaccine development.PMID:37562277 | DOI:10.1016/j.imbio.2023.152725 (Source: Immunobiology)
Source: Immunobiology - August 10, 2023 Category: Allergy & Immunology Authors: Xuechun Liao Jinlei He Ruanyan Wang Jianhui Zhang Shulan Wei Yuying Xiao Qi Zhou Xiaoting Zheng Zheying Zhu Zhiwan Zheng Jiao Li Zheng Zeng Dali Chen Jianping Chen Source Type: research

PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children
Immunobiology. 2023 Aug 3;228(5):152724. doi: 10.1016/j.imbio.2023.152724. Online ahead of print.ABSTRACTPDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D genetic variants have been associated with asthma susceptibility. Therefore, this study aimed to investigate the association between PDE4D variants (and haplotypes) with asthma and atopy in a Brazilian population. The study comprised 1,246 unrelated participants from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was performed using the Illumina 2.5 Human Omni bead chip. Multivariate logistic regression was us...
Source: Immunobiology - August 7, 2023 Category: Allergy & Immunology Authors: Hatilla Dos Santos Silva Helena Mariana Pitangueira Teixeira Luciano Gama da Silva Gomes Álvaro A Cruz Neuza Maria Alcantara-Neves Maur ício Barreto Camila Alexandrina Figueiredo Ryan Dos Santos Costa Source Type: research

PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children
Immunobiology. 2023 Aug 3;228(5):152724. doi: 10.1016/j.imbio.2023.152724. Online ahead of print.ABSTRACTPDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D genetic variants have been associated with asthma susceptibility. Therefore, this study aimed to investigate the association between PDE4D variants (and haplotypes) with asthma and atopy in a Brazilian population. The study comprised 1,246 unrelated participants from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was performed using the Illumina 2.5 Human Omni bead chip. Multivariate logistic regression was us...
Source: Immunobiology - August 7, 2023 Category: Allergy & Immunology Authors: Hatilla Dos Santos Silva Helena Mariana Pitangueira Teixeira Luciano Gama da Silva Gomes Álvaro A Cruz Neuza Maria Alcantara-Neves Maur ício Barreto Camila Alexandrina Figueiredo Ryan Dos Santos Costa Source Type: research

PDE4D gene variants and haplotypes are associated with asthma and atopy in Brazilian children
Immunobiology. 2023 Aug 3;228(5):152724. doi: 10.1016/j.imbio.2023.152724. Online ahead of print.ABSTRACTPDE4D (Phosphodiesterase 4D) gene encodes a hydrolase of cyclic AMP. PDE4D genetic variants have been associated with asthma susceptibility. Therefore, this study aimed to investigate the association between PDE4D variants (and haplotypes) with asthma and atopy in a Brazilian population. The study comprised 1,246 unrelated participants from the SCAALA (Social Changes Asthma and Allergy in Latin America) program. Genotyping was performed using the Illumina 2.5 Human Omni bead chip. Multivariate logistic regression was us...
Source: Immunobiology - August 7, 2023 Category: Allergy & Immunology Authors: Hatilla Dos Santos Silva Helena Mariana Pitangueira Teixeira Luciano Gama da Silva Gomes Álvaro A Cruz Neuza Maria Alcantara-Neves Maur ício Barreto Camila Alexandrina Figueiredo Ryan Dos Santos Costa Source Type: research

Clinical study of autonomic dysfunction in patients with autoimmune encephalitis
CONCLUSION: This study demonstrated the comparisons between autonomic dysfunction group and autonomic dysfunction-free group and provided insights into better diagnosis and treatment.PMID:37543010 | DOI:10.1016/j.imbio.2023.152711 (Source: Immunobiology)
Source: Immunobiology - August 5, 2023 Category: Allergy & Immunology Authors: Jiao He Yajun Lian Source Type: research

Clinical study of autonomic dysfunction in patients with autoimmune encephalitis
CONCLUSION: This study demonstrated the comparisons between autonomic dysfunction group and autonomic dysfunction-free group and provided insights into better diagnosis and treatment.PMID:37543010 | DOI:10.1016/j.imbio.2023.152711 (Source: Immunobiology)
Source: Immunobiology - August 5, 2023 Category: Allergy & Immunology Authors: Jiao He Yajun Lian Source Type: research

Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains
Immunobiology. 2023 Jul 28;228(5):152720. doi: 10.1016/j.imbio.2023.152720. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of severe COVID-19 disease can be challenging in immunocompromized patients due to newly emerging virus variants of concern (VOC) escaping the humoral response. Thus, T cells recognizing to date unmutated epitopes are not only relevant for patients' immune responses against VOC, but might also serve as a therapeutic option for patients with severe COVID-19 disease in the future, e.g. following allogenic stem cell transplantation.METHODS: To this purpose, the activation, cytokine profile and spec...
Source: Immunobiology - August 4, 2023 Category: Allergy & Immunology Authors: Hannah Reimann Carolin Moosmann Kilian Schober Vanessa Lang Johan Verhagen Julia Zeun Andreas Mackensen Anita N Kremer Simon V ölkl Michael Aigner Source Type: research

Identification and characterization of T-cell receptors with therapeutic potential showing conserved specificity against all SARS-CoV 2 strains
Immunobiology. 2023 Jul 28;228(5):152720. doi: 10.1016/j.imbio.2023.152720. Online ahead of print.ABSTRACTINTRODUCTION: Treatment of severe COVID-19 disease can be challenging in immunocompromized patients due to newly emerging virus variants of concern (VOC) escaping the humoral response. Thus, T cells recognizing to date unmutated epitopes are not only relevant for patients' immune responses against VOC, but might also serve as a therapeutic option for patients with severe COVID-19 disease in the future, e.g. following allogenic stem cell transplantation.METHODS: To this purpose, the activation, cytokine profile and spec...
Source: Immunobiology - August 4, 2023 Category: Allergy & Immunology Authors: Hannah Reimann Carolin Moosmann Kilian Schober Vanessa Lang Johan Verhagen Julia Zeun Andreas Mackensen Anita N Kremer Simon V ölkl Michael Aigner Source Type: research

Limosilactobacillus fermentum modulates the gut-airway axis by improving the immune response through FOXP3 activation on combined allergic rhinitis and asthma syndrome (CARAS)
Immunobiology. 2023 Jul 26;228(5):152721. doi: 10.1016/j.imbio.2023.152721. Online ahead of print.ABSTRACTCombined allergic rhinitis and asthma syndrome (CARAS) is an allergic airway inflammatory disorder orchestrated by the type 2 immune response. The close gut-lung relationship has been described, however, the effect of gut-modulating agents such as probiotics in allergic airway disorder is unclear. Thus, the goal of this study was to evaluate theLimosilactobacillus fermentumsupplementation in animals with CARAS. Therefore, BALB/c mice were ovalbumin (OVA) -sensitized and -challenged after being supplemented withL. ferme...
Source: Immunobiology - August 2, 2023 Category: Allergy & Immunology Authors: Raquel F P Cavalcanti Francisco A A F Gadelha La ércia K D Paiva Ferreira Larissa A M Paiva Ferreira Jos é V Chaves Júnior Rayanne S de Ara újo Batista Taynara B L Melo F ábio S de Souza Adriano F Alves Le ônia Maria Batista Marcia R Piuvezam Source Type: research

Limosilactobacillus fermentum modulates the gut-airway axis by improving the immune response through FOXP3 activation on combined allergic rhinitis and asthma syndrome (CARAS)
Immunobiology. 2023 Jul 26;228(5):152721. doi: 10.1016/j.imbio.2023.152721. Online ahead of print.ABSTRACTCombined allergic rhinitis and asthma syndrome (CARAS) is an allergic airway inflammatory disorder orchestrated by the type 2 immune response. The close gut-lung relationship has been described, however, the effect of gut-modulating agents such as probiotics in allergic airway disorder is unclear. Thus, the goal of this study was to evaluate theLimosilactobacillus fermentumsupplementation in animals with CARAS. Therefore, BALB/c mice were ovalbumin (OVA) -sensitized and -challenged after being supplemented withL. ferme...
Source: Immunobiology - August 2, 2023 Category: Allergy & Immunology Authors: Raquel F P Cavalcanti Francisco A A F Gadelha La ércia K D Paiva Ferreira Larissa A M Paiva Ferreira Jos é V Chaves Júnior Rayanne S de Ara újo Batista Taynara B L Melo F ábio S de Souza Adriano F Alves Le ônia Maria Batista Marcia R Piuvezam Source Type: research

PD1 is transcriptionally regulated by LEF1 in mature T cells
Immunobiology. 2023 Jul 20;228(5):152708. doi: 10.1016/j.imbio.2023.152708. Online ahead of print.ABSTRACTThe role of programmed cell death 1 (PD1) in cancer immune evasion is of considerable importance, prompting the development of monoclonal antibodies that specifically target PD-1 to enhance the immune system for cancer therapy. Nevertheless, the efficacy of PD1/programmed cell death-Ligand 1 (PD-L1) blocking antibodies is limited to certain patients or tumor types. Although researchers have demonstrated the influence of PD-1 on the positive selection of T cells, its effect on the T-cell repertoire remains uncertain. Ly...
Source: Immunobiology - July 31, 2023 Category: Allergy & Immunology Authors: Pin Zhao Lanming Sun Cong Zhao Samiullah Malik Source Type: research

PD1 is transcriptionally regulated by LEF1 in mature T cells
Immunobiology. 2023 Jul 20;228(5):152708. doi: 10.1016/j.imbio.2023.152708. Online ahead of print.ABSTRACTThe role of programmed cell death 1 (PD1) in cancer immune evasion is of considerable importance, prompting the development of monoclonal antibodies that specifically target PD-1 to enhance the immune system for cancer therapy. Nevertheless, the efficacy of PD1/programmed cell death-Ligand 1 (PD-L1) blocking antibodies is limited to certain patients or tumor types. Although researchers have demonstrated the influence of PD-1 on the positive selection of T cells, its effect on the T-cell repertoire remains uncertain. Ly...
Source: Immunobiology - July 31, 2023 Category: Allergy & Immunology Authors: Pin Zhao Lanming Sun Cong Zhao Samiullah Malik Source Type: research