Levels of soluble TNF receptors (sTNFR1 and sTNFR2) increase with clinical worsening of patients and are related to COVID-19 mortality
Immunobiology. 2023 Sep 15;229(1):152748. doi: 10.1016/j.imbio.2023.152748. Online ahead of print.ABSTRACTThe present study aimed to inspect the serum levels of the soluble receptors, sTNFR1 and sTNFR2, in patients with COVID-19. The large production of inflammatory cytokines is an essential process in the pathogenesis of COVID-19. TNF is a multifaceted proinflammatory cytokine which has soluble and membrane receptors. Thus, knowing the role of these receptors will help better understand this disease's immunopathogenesis. We included 131 patients confirmed for SARS-CoV-2, separated into three groups: ward patients without ...
Source: Immunobiology - December 21, 2023 Category: Allergy & Immunology Authors: Melayne Rocha Aciole Juliana Prado Gon çales Patr ícia Areias Feitosa Neves Cynthia Regina Pedrosa Soares Marta Iglis de Oliveira Heloisa Ramos Lacerda de Melo Reginaldo Gon çalves de Lima Neto L íbia Cristina Rocha Vilela Moura Paulo Sergio Ramos Ara Source Type: research
Levels of soluble TNF receptors (sTNFR1 and sTNFR2) increase with clinical worsening of patients and are related to COVID-19 mortality
Immunobiology. 2023 Sep 15;229(1):152748. doi: 10.1016/j.imbio.2023.152748. Online ahead of print.ABSTRACTThe present study aimed to inspect the serum levels of the soluble receptors, sTNFR1 and sTNFR2, in patients with COVID-19. The large production of inflammatory cytokines is an essential process in the pathogenesis of COVID-19. TNF is a multifaceted proinflammatory cytokine which has soluble and membrane receptors. Thus, knowing the role of these receptors will help better understand this disease's immunopathogenesis. We included 131 patients confirmed for SARS-CoV-2, separated into three groups: ward patients without ...
Source: Immunobiology - December 21, 2023 Category: Allergy & Immunology Authors: Melayne Rocha Aciole Juliana Prado Gon çales Patr ícia Areias Feitosa Neves Cynthia Regina Pedrosa Soares Marta Iglis de Oliveira Heloisa Ramos Lacerda de Melo Reginaldo Gon çalves de Lima Neto L íbia Cristina Rocha Vilela Moura Paulo Sergio Ramos Ara Source Type: research
Levels of soluble TNF receptors (sTNFR1 and sTNFR2) increase with clinical worsening of patients and are related to COVID-19 mortality
Immunobiology. 2023 Sep 15;229(1):152748. doi: 10.1016/j.imbio.2023.152748. Online ahead of print.ABSTRACTThe present study aimed to inspect the serum levels of the soluble receptors, sTNFR1 and sTNFR2, in patients with COVID-19. The large production of inflammatory cytokines is an essential process in the pathogenesis of COVID-19. TNF is a multifaceted proinflammatory cytokine which has soluble and membrane receptors. Thus, knowing the role of these receptors will help better understand this disease's immunopathogenesis. We included 131 patients confirmed for SARS-CoV-2, separated into three groups: ward patients without ...
Source: Immunobiology - December 21, 2023 Category: Allergy & Immunology Authors: Melayne Rocha Aciole Juliana Prado Gon çales Patr ícia Areias Feitosa Neves Cynthia Regina Pedrosa Soares Marta Iglis de Oliveira Heloisa Ramos Lacerda de Melo Reginaldo Gon çalves de Lima Neto L íbia Cristina Rocha Vilela Moura Paulo Sergio Ramos Ara Source Type: research
Up-regulation of scleral C5b-9 and its regulation of the NLRP3 inflammasome in a form-deprivation myopia mouse model
CONCLUSIONS: Complement cascades are activated in FD myopia model. Upregulation of C5b-9 might participate in scleral remodeling during myopia progression via regulation of NLRP3 inflammasome activation.PMID:38118343 | DOI:10.1016/j.imbio.2023.152776 (Source: Immunobiology)
Source: Immunobiology - December 20, 2023 Category: Allergy & Immunology Authors: Kang Xiao Zhengyu Chen Songqing He Qin Long Source Type: research
Chlorella vulgaris extract and Imiquimod as new therapeutic targets for leishmaniasis: An immunological approach
Immunobiology. 2023 Dec 14;229(1):152779. doi: 10.1016/j.imbio.2023.152779. Online ahead of print.ABSTRACTThe therapeutic regimen for the treatment of American Tegumentary Leishmaniasis (ATL) is targeted at the death of the parasite; therefore, it is essential to develop a treatment that can act on the parasite, combined with the modulation of the inflammatory profile. Thus, the aim of this study was to make an in vitro evaluation of the therapeutic potential of Chlorella vulgaris extract (CV) and Imiquimod for ATL. Selectivity indices (SI) were determined by inhibitory concentration assays (IC50) in L. braziliensis cells ...
Source: Immunobiology - December 20, 2023 Category: Allergy & Immunology Authors: Maria Gabriella Nunes de Melo Isabelle Barreto da Silva Moreira Reino Victor Vaitkevicius-Ant ão Jady Moreira da Silva Jos é Noé da Silva Júnior Alexsandra Fraz ão de Andrade Raquel Pedrosa Bezerra Daniela de Ara újo Viana Marques Silvana de F átim Source Type: research
Up-regulation of scleral C5b-9 and its regulation of the NLRP3 inflammasome in a form-deprivation myopia mouse model
CONCLUSIONS: Complement cascades are activated in FD myopia model. Upregulation of C5b-9 might participate in scleral remodeling during myopia progression via regulation of NLRP3 inflammasome activation.PMID:38118343 | DOI:10.1016/j.imbio.2023.152776 (Source: Immunobiology)
Source: Immunobiology - December 20, 2023 Category: Allergy & Immunology Authors: Kang Xiao Zhengyu Chen Songqing He Qin Long Source Type: research
Chlorella vulgaris extract and Imiquimod as new therapeutic targets for leishmaniasis: An immunological approach
Immunobiology. 2023 Dec 14;229(1):152779. doi: 10.1016/j.imbio.2023.152779. Online ahead of print.ABSTRACTThe therapeutic regimen for the treatment of American Tegumentary Leishmaniasis (ATL) is targeted at the death of the parasite; therefore, it is essential to develop a treatment that can act on the parasite, combined with the modulation of the inflammatory profile. Thus, the aim of this study was to make an in vitro evaluation of the therapeutic potential of Chlorella vulgaris extract (CV) and Imiquimod for ATL. Selectivity indices (SI) were determined by inhibitory concentration assays (IC50) in L. braziliensis cells ...
Source: Immunobiology - December 20, 2023 Category: Allergy & Immunology Authors: Maria Gabriella Nunes de Melo Isabelle Barreto da Silva Moreira Reino Victor Vaitkevicius-Ant ão Jady Moreira da Silva Jos é Noé da Silva Júnior Alexsandra Fraz ão de Andrade Raquel Pedrosa Bezerra Daniela de Ara újo Viana Marques Silvana de F átim Source Type: research
ADAR1 regulates macrophage polarization and is protective against liver ischemia and reperfusion injury
In this study, we mainly adopted a mouse model of LIRI and cellular experiments with hypoxia and reoxygenation (HR) treatment to explore the regulatory roles of ADAR1 on liver macrophages under LIRI conditions. We found that IRI caused decreased ADAR1 in liver tissues and remarkable changes of liver macrophage polarization and profiles. ADAR1 supplementation alleviated the pathological injury caused by IRI and accelerated the activation of M2 macrophages in the liver of IRI mice. Increased hypoxia duration reduced ADAR1 expression levels in murine RAW264.7 macrophages at the transcriptional level. Further overexpression of...
Source: Immunobiology - December 19, 2023 Category: Allergy & Immunology Authors: Linxiao Wang Chujun Duan Xiuhua Wu Jiangang Xie Xiaojun Zhao Yi Si Dan Wu Yifan Wang Peng Zhao Jijun Chen Wen Yin Junjie Li Source Type: research
ADAR1 regulates macrophage polarization and is protective against liver ischemia and reperfusion injury
In this study, we mainly adopted a mouse model of LIRI and cellular experiments with hypoxia and reoxygenation (HR) treatment to explore the regulatory roles of ADAR1 on liver macrophages under LIRI conditions. We found that IRI caused decreased ADAR1 in liver tissues and remarkable changes of liver macrophage polarization and profiles. ADAR1 supplementation alleviated the pathological injury caused by IRI and accelerated the activation of M2 macrophages in the liver of IRI mice. Increased hypoxia duration reduced ADAR1 expression levels in murine RAW264.7 macrophages at the transcriptional level. Further overexpression of...
Source: Immunobiology - December 19, 2023 Category: Allergy & Immunology Authors: Linxiao Wang Chujun Duan Xiuhua Wu Jiangang Xie Xiaojun Zhao Yi Si Dan Wu Yifan Wang Peng Zhao Jijun Chen Wen Yin Junjie Li Source Type: research
Vitexin along with verapamil downregulates efflux pump P-glycoprotein in macrophages and potentiate M1 to M2 switching via TLR4-NF- κB-TNFR2 pathway in lipopolysaccharide treated mice
In conclusion, combined vitexin and verapamil treatment could be used as a promising therapy to regulate P-gp expression and protection against LPS mediated sepsis and inflammatory damages.PMID:38103391 | DOI:10.1016/j.imbio.2023.152767 (Source: Immunobiology)
Source: Immunobiology - December 16, 2023 Category: Allergy & Immunology Authors: Ayantika Kundu Pratiti Ghosh Biswadev Bishayi Source Type: research
Vitexin along with verapamil downregulates efflux pump P-glycoprotein in macrophages and potentiate M1 to M2 switching via TLR4-NF- κB-TNFR2 pathway in lipopolysaccharide treated mice
In conclusion, combined vitexin and verapamil treatment could be used as a promising therapy to regulate P-gp expression and protection against LPS mediated sepsis and inflammatory damages.PMID:38103391 | DOI:10.1016/j.imbio.2023.152767 (Source: Immunobiology)
Source: Immunobiology - December 16, 2023 Category: Allergy & Immunology Authors: Ayantika Kundu Pratiti Ghosh Biswadev Bishayi Source Type: research
Vitexin along with verapamil downregulates efflux pump P-glycoprotein in macrophages and potentiate M1 to M2 switching via TLR4-NF- κB-TNFR2 pathway in lipopolysaccharide treated mice
In conclusion, combined vitexin and verapamil treatment could be used as a promising therapy to regulate P-gp expression and protection against LPS mediated sepsis and inflammatory damages.PMID:38103391 | DOI:10.1016/j.imbio.2023.152767 (Source: Immunobiology)
Source: Immunobiology - December 16, 2023 Category: Allergy & Immunology Authors: Ayantika Kundu Pratiti Ghosh Biswadev Bishayi Source Type: research
Alteration of PBMC transcriptome profile after interaction with multipotent mesenchymal stromal cells under "physiological" hypoxia
Immunobiology. 2023 Nov 23;229(1):152766. doi: 10.1016/j.imbio.2023.152766. Online ahead of print.ABSTRACTMultipotent mesenchymal stromal cells (MSCs) have demonstrated a pronounced immunosuppressive activity, the manifestation of which depends on the microenvironmental factors, including O2 level. Here we examined the effects of MSCs on transcriptomic profile of allogeneic phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMCs) after interaction at ambient (20%) or "physiological" hypoxia (5%) O2. As revealed with microarray analysis, PBMC transcriptome at 20% O2 was more affected, which was manifested as...
Source: Immunobiology - December 13, 2023 Category: Allergy & Immunology Authors: A N Gornostaeva P I Bobyleva E R Andreeva B Sh Gogiya L B Buravkova Source Type: research
Alteration of PBMC transcriptome profile after interaction with multipotent mesenchymal stromal cells under "physiological" hypoxia
Immunobiology. 2023 Nov 23;229(1):152766. doi: 10.1016/j.imbio.2023.152766. Online ahead of print.ABSTRACTMultipotent mesenchymal stromal cells (MSCs) have demonstrated a pronounced immunosuppressive activity, the manifestation of which depends on the microenvironmental factors, including O2 level. Here we examined the effects of MSCs on transcriptomic profile of allogeneic phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMCs) after interaction at ambient (20%) or "physiological" hypoxia (5%) O2. As revealed with microarray analysis, PBMC transcriptome at 20% O2 was more affected, which was manifested as...
Source: Immunobiology - December 13, 2023 Category: Allergy & Immunology Authors: A N Gornostaeva P I Bobyleva E R Andreeva B Sh Gogiya L B Buravkova Source Type: research
Alteration of PBMC transcriptome profile after interaction with multipotent mesenchymal stromal cells under "physiological" hypoxia
Immunobiology. 2023 Nov 23;229(1):152766. doi: 10.1016/j.imbio.2023.152766. Online ahead of print.ABSTRACTMultipotent mesenchymal stromal cells (MSCs) have demonstrated a pronounced immunosuppressive activity, the manifestation of which depends on the microenvironmental factors, including O2 level. Here we examined the effects of MSCs on transcriptomic profile of allogeneic phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMCs) after interaction at ambient (20%) or "physiological" hypoxia (5%) O2. As revealed with microarray analysis, PBMC transcriptome at 20% O2 was more affected, which was manifested as...
Source: Immunobiology - December 13, 2023 Category: Allergy & Immunology Authors: A N Gornostaeva P I Bobyleva E R Andreeva B Sh Gogiya L B Buravkova Source Type: research
