Alterations in Helios+ T cell subsets in peripheral blood of early-stage lung adenocarcinoma patients: Implications for early diagnosis
CONCLUSION: Helios+ T cell subsets in peripheral blood of early-stage LUAD patients has changed significantly, which may be related to the pathogenesis of LUAD and could help for early diagnosis of LUAD.PMID:37778128 | DOI:10.1016/j.imbio.2023.152749 (Source: Immunobiology)
Source: Immunobiology - October 1, 2023 Category: Allergy & Immunology Authors: Yiming Zhao Ming Zhao Meng Li Xiancan Ma Mohan Zheng Yuying Nie Yaoyi Zhu Jiaxin Ren Ainizati Hasimu Zihang Yuan Qi Li Ayibaota Bahabayi Zhonghui Zhang Xingyue Zeng Chen Liu Source Type: research
Identification and validation of a novel NK cells-related signature to predict prognosis and immune microenvironment in LUAD
Immunobiology. 2023 Sep 23;228(6):152751. doi: 10.1016/j.imbio.2023.152751. Online ahead of print.ABSTRACTBACKGROUND: The prevalence and fatality rates of lung cancer are experiencing a rapid escalation. Natural Killer (NK) cells have been established to have a crucial role in both tumor initiation and progression. Nevertheless, uncertainties persist regarding their precise implications in the prognosis of LUAD.METHODS: The data were obtained from reputable sources, such as the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) database, and our internally generated sequencing data. Utilizing the TCGA data as a back...
Source: Immunobiology - September 29, 2023 Category: Allergy & Immunology Authors: Chenghu Song Weici Liu Guanyu Jiang Zhao He Ruixin Wang Xiaokun Wang Ruo Chen Wenjun Mao Shaojin Zhu Source Type: research
Cafeteria diet-induced obesity remodels immune response in acute Trypanosoma cruzi infection
CONCLUSIONS: These results indicate that a CAF can impair the cell-mediated immune response against T. cruzi.PMID:37774598 | DOI:10.1016/j.imbio.2023.152747 (Source: Immunobiology)
Source: Immunobiology - September 29, 2023 Category: Allergy & Immunology Authors: Amanda Goulart Naira Ferreira Anchieta Pedro Alexandre Sampaio V ânia Brazão Jefferson Luiz Da Silva Gisele Bulh ões Portapilla Andressa Duarte Daiane Yukie Tezuca Maiara Voltarelli Providello Angelita Maria Stabile Jos é Clóvis do Prado Source Type: research
Identification and validation of a novel NK cells-related signature to predict prognosis and immune microenvironment in LUAD
Immunobiology. 2023 Sep 23;228(6):152751. doi: 10.1016/j.imbio.2023.152751. Online ahead of print.ABSTRACTBACKGROUND: The prevalence and fatality rates of lung cancer are experiencing a rapid escalation. Natural Killer (NK) cells have been established to have a crucial role in both tumor initiation and progression. Nevertheless, uncertainties persist regarding their precise implications in the prognosis of LUAD.METHODS: The data were obtained from reputable sources, such as the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) database, and our internally generated sequencing data. Utilizing the TCGA data as a back...
Source: Immunobiology - September 29, 2023 Category: Allergy & Immunology Authors: Chenghu Song Weici Liu Guanyu Jiang Zhao He Ruixin Wang Xiaokun Wang Ruo Chen Wenjun Mao Shaojin Zhu Source Type: research
Cafeteria diet-induced obesity remodels immune response in acute Trypanosoma cruzi infection
CONCLUSIONS: These results indicate that a CAF can impair the cell-mediated immune response against T. cruzi.PMID:37774598 | DOI:10.1016/j.imbio.2023.152747 (Source: Immunobiology)
Source: Immunobiology - September 29, 2023 Category: Allergy & Immunology Authors: Amanda Goulart Naira Ferreira Anchieta Pedro Alexandre Sampaio V ânia Brazão Jefferson Luiz Da Silva Gisele Bulh ões Portapilla Andressa Duarte Daiane Yukie Tezuca Maiara Voltarelli Providello Angelita Maria Stabile Jos é Clóvis do Prado Source Type: research
PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis
CONCLUSION: There is a significant change in the concentration of serum PRICKLE1 mRNAin patients with Ankylosing spondylitis, and the degree of gene methylation is significantly reduced, suggesting that PRICKLE1 gene maybe involved in the pathogenesis of Ankylosing spondylitis, which may be useful for predicting the occurrence of AS and finding new early screening indicators.PMID:37742487 | DOI:10.1016/j.imbio.2023.152742 (Source: Immunobiology)
Source: Immunobiology - September 24, 2023 Category: Allergy & Immunology Authors: Tingting Zhou Xinqi Wang Jiangping Kong Lingxiang Yu Huimin Xie Feier Wang Shenqian Xu Zongwen Shuai Qiang Zhou Faming Pan Source Type: research
PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis
CONCLUSION: There is a significant change in the concentration of serum PRICKLE1 mRNAin patients with Ankylosing spondylitis, and the degree of gene methylation is significantly reduced, suggesting that PRICKLE1 gene maybe involved in the pathogenesis of Ankylosing spondylitis, which may be useful for predicting the occurrence of AS and finding new early screening indicators.PMID:37742487 | DOI:10.1016/j.imbio.2023.152742 (Source: Immunobiology)
Source: Immunobiology - September 24, 2023 Category: Allergy & Immunology Authors: Tingting Zhou Xinqi Wang Jiangping Kong Lingxiang Yu Huimin Xie Feier Wang Shenqian Xu Zongwen Shuai Qiang Zhou Faming Pan Source Type: research
PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis
CONCLUSION: There is a significant change in the concentration of serum PRICKLE1 mRNAin patients with Ankylosing spondylitis, and the degree of gene methylation is significantly reduced, suggesting that PRICKLE1 gene maybe involved in the pathogenesis of Ankylosing spondylitis, which may be useful for predicting the occurrence of AS and finding new early screening indicators.PMID:37742487 | DOI:10.1016/j.imbio.2023.152742 (Source: Immunobiology)
Source: Immunobiology - September 24, 2023 Category: Allergy & Immunology Authors: Tingting Zhou Xinqi Wang Jiangping Kong Lingxiang Yu Huimin Xie Feier Wang Shenqian Xu Zongwen Shuai Qiang Zhou Faming Pan Source Type: research
PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis
CONCLUSION: There is a significant change in the concentration of serum PRICKLE1 mRNAin patients with Ankylosing spondylitis, and the degree of gene methylation is significantly reduced, suggesting that PRICKLE1 gene maybe involved in the pathogenesis of Ankylosing spondylitis, which may be useful for predicting the occurrence of AS and finding new early screening indicators.PMID:37742487 | DOI:10.1016/j.imbio.2023.152742 (Source: Immunobiology)
Source: Immunobiology - September 24, 2023 Category: Allergy & Immunology Authors: Tingting Zhou Xinqi Wang Jiangping Kong Lingxiang Yu Huimin Xie Feier Wang Shenqian Xu Zongwen Shuai Qiang Zhou Faming Pan Source Type: research
PRICKLE1 gene methylation and abnormal transcription in Chinese patients with ankylosing spondylitis
CONCLUSION: There is a significant change in the concentration of serum PRICKLE1 mRNAin patients with Ankylosing spondylitis, and the degree of gene methylation is significantly reduced, suggesting that PRICKLE1 gene maybe involved in the pathogenesis of Ankylosing spondylitis, which may be useful for predicting the occurrence of AS and finding new early screening indicators.PMID:37742487 | DOI:10.1016/j.imbio.2023.152742 (Source: Immunobiology)
Source: Immunobiology - September 24, 2023 Category: Allergy & Immunology Authors: Tingting Zhou Xinqi Wang Jiangping Kong Lingxiang Yu Huimin Xie Feier Wang Shenqian Xu Zongwen Shuai Qiang Zhou Faming Pan Source Type: research
Fluid shear stress enhances dendritic cell activation
In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744 (Source: Immunobiology)
Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research
Fluid shear stress enhances dendritic cell activation
In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744 (Source: Immunobiology)
Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research
Fluid shear stress enhances dendritic cell activation
In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744 (Source: Immunobiology)
Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research
Fluid shear stress enhances dendritic cell activation
In this study, dendritic cells were activated by sustained exposure to circulatory levels of fluid shear stress using a cone-and-plate flow device and analyzed for activation markers. After 1 h of shear stress exposure, an increase in cytokine release was present in immortalized cells as well as phosphorylation of the proteins NF-κB and cFos in primary DCs. Changes in DC morphology, metabolism and proliferation were also observed. These compelling new findings point to the potential for using FSS to activate DCs for ex vivo therapeutics.PMID:37729773 | DOI:10.1016/j.imbio.2023.152744 (Source: Immunobiology)
Source: Immunobiology - September 20, 2023 Category: Allergy & Immunology Authors: Jenna A Dombroski Schyler J Rowland Abigail R Fabiano Samantha V Knoblauch Jacob M Hope Michael R King Source Type: research
Moderate and high-intensity interval training protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats
Immunobiology. 2023 Sep 13;228(6):152745. doi: 10.1016/j.imbio.2023.152745. Online ahead of print.ABSTRACTDiabetes Mellitus (DM) can damage the function of metabolic tissues, including the liver. Liver macrophages are the first responders to tissue damage or exercise. We sought to determine whether eight weeks of interval training (HIIT & MIIT) protect against diabetes-induced modulation of hepatic CD86 and CD206 expression associated with the amelioration of insulin resistance and inflammation in rats. Thirty rats were divided into six groups, including a control group, MIIT, HIIT, DM, DM + MIIT, and DM + HIIT (n = 5 ...
Source: Immunobiology - September 18, 2023 Category: Allergy & Immunology Authors: Reza Sheikh Saeid Shakerian Seyed Reza Fatemi Tabatabaei Abdolhamid Habibi Source Type: research
