Immunological Aspects of Kabuki Syndrome: A Retrospective Multicenter Study of the Italian Primary Immunodeficiency Network (IPINet)
In conclusion, immunological manifestations of KS in our cohort include susceptibility to infections, antibody deficiency, and autoimmunity. Autoimmune cytopenia is correlated with thymectomy and elevated CD3 + TCRαβ + CD4-CD8-T-cells, and benefits from treatment with mycophenolate. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Source Type: research
Treatment with Elapegademase Restores Immunity in Infants with Adenosine Deaminase Deficient Severe Combined Immunodeficiency
ConclusionRevcovi was safe and effective as initial therapy to restore immune function in these newly diagnosed infants with ADA-SCID, however, time course and degree of reconstitution varied. Revcovi dose may need to be optimized based on immune reconstitution, clinical status, and biochemical data. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Source Type: research
Desflurane alleviates LPS-induced acute lung injury by modulating let-7b-5p/HOXA9 axis
AbstractAcute lung injury (ALI) is characterized by acute respiratory failure with tachypnea and widespread alveolar infiltrates, badly affecting patients ’ health. Desflurane (Des) is effective against lung injury. However, its mechanism in ALI remains unknown. BEAS-2B cells were incubated with lipopolysaccharide (LPS) to construct an ALI cell model. Cell apoptosis was evaluated using flow cytometry. Enzyme-linked immunosorbent assay (ELISA) was em ployed to examine the levels of inflammatory cytokines. Interactions among let-7b-5p, homeobox A9 (HOXA9), and suppressor of cytokine signaling 2 (SOCS2) were verified using ...
Source: Immunologic Research - April 27, 2024 Category: Allergy & Immunology Source Type: research
Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
ConclusionsPrescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures. (Source: Advances in Therapy)
Source: Advances in Therapy - April 26, 2024 Category: Drugs & Pharmacology Source Type: research
Redox Biomarkers – An Effective Tool for Diagnosing COVID-19 Patients and Convalescents
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 26, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
