Autoimmune diseases and the risk of bladder cancer: A Mendelian randomization analysis
CONCLUSION: This study provides evidence of a causal relationship between AIDs and BC risk at the genetic level, confirming a causal relationship between RA and MS in increasing the risk of BC.PMID:38692170 | DOI:10.1016/j.jaut.2024.103231 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 1, 2024 Category: Allergy & Immunology Authors: Jun Li Cui Cheng Jiajun Zhang Source Type: research
Animal models of studying the pathogenesis of multi-organ tissue damage in lupus
Clin Immunol. 2024 Apr 29:110231. doi: 10.1016/j.clim.2024.110231. Online ahead of print.ABSTRACTModerate-to-severe systemic lupus erythematosus (SLE) is characterized by extensive autoantibody deposition and persistent autoinflammation. As the existing animal models are limited in accurately reproducing the pathological characteristics of human SLE, we introduced a novel animal model simulating multi-organ autoinflammation through intra-organ injections. The model closely mimicked key features of SLE, including IgG deposition, inflammation, and tissue damage. The model could be used to assess the roles of IgG, immune cell...
Source: Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Xuefei Wang Guo-Min Deng Source Type: research
The role of IFI16 in regulating PANoptosis and implication in heart diseases
Cell Death Discov. 2024 May 1;10(1):204. doi: 10.1038/s41420-024-01978-5.ABSTRACTInterferon Gamma Inducible Protein 16 (IFI16) belongs to the HIN-200 protein family and is pivotal in immunological responses. Serving as a DNA sensor, IFI16 identifies viral and aberrant DNA, triggering immune and inflammatory responses. It is implicated in diverse cellular death mechanisms, such as pyroptosis, apoptosis, and necroptosis. Notably, these processes are integral to the emergent concept of PANoptosis, which encompasses cellular demise and inflammatory pathways. Current research implies a significant regulatory role for IFI16 in P...
Source: Atherosclerosis - May 1, 2024 Category: Cardiology Authors: Xindi Chang Bei Wang Yingli Zhao Bing Deng Ping Liu Yiru Wang Source Type: research
Safety and immunogenicity of a polyvalent DNA-protein HIV vaccine with matched Env immunogens delivered as a prime-boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial
Lancet HIV. 2024 May;11(5):e285-e299. doi: 10.1016/S2352-3018(24)00036-5.ABSTRACTBACKGROUND: An effective HIV vaccine will most likely need to have potent immunogenicity and broad cross-subtype coverage. The aim of the HIV Vaccine Trials Network (HVTN) 124 was to evaluate safety and immunogenicity of a unique polyvalent DNA-protein HIV vaccine with matching envelope (Env) immunogens.METHODS: HVTN 124 was a randomised, phase 1, placebo-controlled, double-blind study, including participants who were HIV seronegative and aged 18-50 years at low risk for infection. The DNA vaccine comprised five plasmids: four copies expressin...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Ian Frank Shuying S Li Nicole Grunenberg Edgar T Overton Samuel T Robinson Hua Zheng Kelly E Seaton Jack R Heptinstall Mary A Allen Kenneth H Mayer Daniel A Culver Michael C Keefer Sri Edupuganti Michael N Pensiero Vijay L Mehra Stephen C De Rosa Daryl E Source Type: research
Distributions of candidate vaccine Targets, virulence Factors, and resistance features of invasive group B Streptococcus using Whole-Genome Sequencing: A Multicenter, population-based surveillance study
CONCLUSIONS: The findings from this large whole-genome sequence of GBS isolates establish important baseline data required for further surveillance and evaluating the impact of future vaccine candidates.PMID:38692955 | DOI:10.1016/j.vaccine.2024.04.062 (Source: Vaccine)
Source: Vaccine - May 1, 2024 Category: Allergy & Immunology Authors: Wenjing Ji Haijian Zhou Jie Li Carl D Britto Zheliang Liu Wen Zhang Jiaxi Du Shabir A Madhi Gaurav Kwatra Ziyaad Dangor Zhengjiang Jin Hang Zhao Yifei Zhao Yu Fang Juan Li Source Type: research
Use of experimental vaccines is ethically permissible during public health emergencies
Vaccine. 2024 May 1:S0264-410X(24)00504-8. doi: 10.1016/j.vaccine.2024.04.065. Online ahead of print.NO ABSTRACTPMID:38692954 | DOI:10.1016/j.vaccine.2024.04.065 (Source: Vaccine)
Source: Vaccine - May 1, 2024 Category: Allergy & Immunology Authors: Ignacio Mastroleo Source Type: research
Abnormal energy metabolism in the pathogenesis of systemic lupus erythematosus
Int Immunopharmacol. 2024 Apr 30;134:112149. doi: 10.1016/j.intimp.2024.112149. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a severe autoimmune disease with significant socioeconomic impact worldwide. Orderly energy metabolism is essential for normal immune function, and disordered energy metabolism is increasingly recognized as an important contributor to the pathogenesis of SLE. Disorders of energy metabolism are characterized by increased reactive oxygen species, ATP deficiency, and abnormal metabolic pathways. Oxygen and mitochondria are critical for the production of ATP, and both mitochondrial...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Shumei Cao Jiao Jiang Haoyuan Yin Lai Wang Qianjin Lu Source Type: research
Disulfiram mediated anti-tumour effect in pituitary neuroendocrine tumours by inducing cuproptosis
CONCLUSION: The present study revealed copper ionophores as a potential class of drugs for PitNET treatment. DSF induced PitNET cell death via cuproptosis and might be a promising option for PitNET therapy.PMID:38692018 | DOI:10.1016/j.intimp.2024.112159 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Ning Huang Yao Feng Yanting Liu Yong Zhang Li Liu Bo Zhang Tao Zhang Zhipeng Su Li Xue Zhe Bao Wu Source Type: research
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling
Int Immunopharmacol. 2024 Apr 30;134:112165. doi: 10.1016/j.intimp.2024.112165. Online ahead of print.ABSTRACTParticulate matter (PM) is considered the fundamental component of atmospheric pollutants and is associated with the pathogenesis of many respiratory diseases. Fibroblast growth factor 10 (FGF10) mediates mesenchymal-epithelial signaling and has been linked with the repair process of PM-induced lung injury (PMLI). However, the pathogenic mechanism of PMLI and the specific FGF10 protective mechanism against this injury are still undetermined. PM was administered in vivo into murine airways or in vitro to human bronc...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yao Qian Qiangqiang Shi Wanting Zhou Baiqi He Haibo Xu Bin Liu Wanqi Miao Saverio Bellusci Chengshui Chen Nian Dong Source Type: research
Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation
Int Immunopharmacol. 2024 Apr 30;134:112143. doi: 10.1016/j.intimp.2024.112143. Online ahead of print.ABSTRACTChronic inflammation is a significant contributor to hypertensive heart failure. Carnosol (Car), primarily derived from the sage plant (Salvia carnosa), exhibits anti-inflammatory properties in a range of systems. Nevertheless, the influence of angiotensin II (Ang II) on cardiac remodeling remains uncharted. Car was shown to protect mice's hearts against Ang II-induced heart damage at dosages of 20 and 40 mg/kg/d. This protection was evident in a concentration-related decrease in the remodeling of the heart and dys...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Diyun Xu Bozhi Ye Liming Lin Yanhong Jin Yuchen Jiang Zhaozheng Zheng Yanghao Chen Xue Han Wei Wang Gaojun Wu Zaishou Zhuang Peiren Shan Guang Liang Source Type: research
Comprehensive quantifications of tumour microenvironment to predict the responsiveness to immunotherapy and prognosis for paediatric neuroblastomas
In this study, the TMEs of neuroblastoma were grouped by their genetic signatures into four distinct subtypes: immune enriched, immune desert, non-proliferative and fibrotic. An Immune Score and a Proliferation Score were constructed based on the molecular features of the subtypes to quantify the immune microenvironment or malignancy degree of cancer cells in neuroblastoma, respectively. The Immune Score correlated with a patient's response to immunotherapy; the Proliferation Score was an independent prognostic biomarker for neuroblastoma and proved to be more accurate than the existing clinical predictors. This double sco...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Mingkun Song Yiming Sun Yikai Hu Chong Wang Yan Jin Yun Liu Yurong Da Qiang Zhao Rongxiu Zheng Long Li Source Type: research
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study
CONCLUSIONS: We substantiated vitiligo's influence on susceptibility to seven autoimmune diseases and conducted a thorough investigation of serum metabolites correlated with vitiligo. Histidine and pyruvate are potential mediators of vitiligo associated with autoimmune diseases.By combining metabolomics with genomics, we provide new perspectives on the etiology of vitiligo and its immune comorbidities.PMID:38691918 | DOI:10.1016/j.intimp.2024.112132 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Siyu Yang Xinglin Hu Puyu Zou Zhuotong Zeng Yibo Hu Rong Xiao Source Type: research
Anti-inflammatory and protective effects of Aripiprazole on TNBS-Induced colitis and associated depression in rats: Role of kynurenine pathway
CONCLUSION: ARP could alleviate IBD-induced colon damage and associated depressive-like behaviors mainly via suppressing inflammatory cytokines activity, serum LPS concentration, and affecting the NF-κB/kynurenine pathway.PMID:38691917 | DOI:10.1016/j.intimp.2024.112158 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Afrooz Mohammadgholi-Beiki Mohammad Sheibani Majid Jafari-Sabet Manijeh Motevalian Parvaneh Rahimi-Moghaddam Source Type: research
Unraveling molecular advancements in chordoma tumorigenesis and treatment response: a review of scientific discoveries and clinical implications
Neurosurg Focus. 2024 May;56(5):E18. doi: 10.3171/2024.2.FOCUS2417.ABSTRACTChordomas are tumors thought to originate from notochordal remnants that occur in midline structures from the cloves of the skull base to the sacrum. In adults, the most common location is the sacrum, followed by the clivus and then mobile spine, while in children a clival origin is most common. Most chordomas are slow growing. Clinical presentation of chordomas tend to occur late, with local invasion and large size often complicating surgical intervention. Radiation therapy with protons has been proven to be an effective adjuvant therapy. Unfortuna...
Source: Neurosurgical Focus - May 1, 2024 Category: Neurosurgery Authors: Michael C Jin Ian D Connolly Karthik Ravi Daniel G Tobert Shannon M MacDonald John H Shin Source Type: research
