The Role of Macrophage Death in Periodontitis: A Review
This article reviews the typical mechanisms underlying macrophage death and its effects on periodontitis. We describe five forms of macrophage death in periodontitis: apoptosis, pyroptosis, necroptosis, ferroptosis, and ETosis. Our review of macrophage death in the pathophysiology of periodontitis enhances comprehension of the pathogenesis of periodontitis that will be useful for clinical practice. Although our review elucidates the complex mechanisms by which macrophage death and inflammatory pathways perpetuate periodontitis, unresolved issues remain, necessitating further research. (Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 Cells
(Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
Nucleic acid vaccine candidates encapsulated with mesoporous silica nanoparticles against MERS-CoV
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - May 1, 2024 Category: Allergy & Immunology Authors: Iman AlmansourB. Rabindran Jermya Nucleic Acid Vaccine Laboratory, Department of Epidemic Diseases Research, Institute for Research and Medical Consultations IRMC, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabiab Department of Nanomedicine Re Source Type: research
SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in humans and to delineate its significance in systemic lupus erythematosus (SLE) patients. We employed multiparametric flow cytometry to investigate the expression of SIT1 in circulating CD8/CD4 + T cells and their respective subsets, comparing healthy controls (HCs) with SLE pat ients. Furthermore, we assessed the levels of granzyme B, perforin, IL-17, and IFN-γ in SIT1-related CD8/CD4 + T cells from both HCs and SLE patients, both before and after PMA stimulation. Clinically, we conducted receiver operati...
Source: Immunologic Research - May 1, 2024 Category: Allergy & Immunology Source Type: research
The immunosuppressive landscape in tumor microenvironment
AbstractRecent advances in cancer immunotherapy, especially immune checkpoint inhibitors (ICIs), have revolutionized the clinical outcome of many cancer patients. Despite the fact that impressive progress has been made in recent decades, the response rate remains unsatisfactory, and many patients do not benefit from ICIs. Herein, we summarized advanced studies and the latest insights on immune inhibitory factors in the tumor microenvironment. Our in-depth discussion and updated landscape of tumor immunosuppressive microenvironment may provide new strategies for reversing tumor immune evasion, enhancing the efficacy of ICIs...
Source: Immunologic Research - May 1, 2024 Category: Allergy & Immunology Source Type: research
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation
TLR7 is critical for recognizing RNA virus infection and initiating antiviral responses. B érouti et al. demonstrate how RNase T2 and PLD exonucleases generate RNA fragments for TLR7 activation, thus providing insights into immune recognition of exogenous RNAs, with potential therapeutic implications. (Source: Immunity)
Source: Immunity - May 1, 2024 Category: Allergy & Immunology Authors: Marleen B érouti, Katja Lammens, Matthias Heiss, Larissa Hansbauer, Stefan Bauernfried, Jan Stöckl, Francesca Pinci, Ignazio Piseddu, Wilhelm Greulich, Meiyue Wang, Christophe Jung, Thomas Fröhlich, Thomas Carell, Karl-Peter Hopfner, Veit Hornung Tags: Article Source Type: research
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification
Multilayered gene regulation orchestrates cell-type-specific cytokine expression. Liu et al. examine the impact of chromatin loop formation on the expression of IFN-γ and IL-22, which are cytokine loci closely located in the genome, and identify an inducible topologically associating domain required for proper IFN-γ production in Th1 cells. Deleting a CTCF-binding site within this d omain leads to lineage-specific cytokine dysregulation and increased susceptibility to pathogens. (Source: Immunity)
Source: Immunity - May 1, 2024 Category: Allergy & Immunology Authors: Chunhong Liu, Hiroyuki Nagashima, Nilisha Fernando, Victor Bass, Jaanam Gopalakrishnan, Sadie Signorella, Will Montgomery, Ai Ing Lim, Oliver Harrison, Lauren Reich, Chen Yao, Hong-Wei Sun, Stephen R. Brooks, Kan Jiang, Vijayaraj Nagarajan, Yongbing Zhao, Tags: Article Source Type: research
N4BP1 coordinates ubiquitin-dependent crosstalk within the I κB kinase family to limit Toll-like receptor signaling and inflammation
The ubiquitin-binding endoribonuclease N4BP1 integrates signals from multiple innate immune receptors to regulate inflammatory cytokine responses. Gitlin et al. find that N4BP1 acts in concert with the noncanonical IκB kinases, TBK1 and IKKε, to suppress late-phase inflammatory gene transcription during Toll-like receptor responses, thereby limiting over-exuberant inflammation. (Source: Immunity)
Source: Immunity - May 1, 2024 Category: Allergy & Immunology Authors: Alexander D. Gitlin, Allie Maltzman, Yuzuka Kanno, Klaus Heger, Rohit Reja, Alexander F. Schubert, Linsey J. Wierciszewski, Homer Pantua, Sharookh B. Kapadia, Seth F. Harris, Joshua D. Webster, Kim Newton, Vishva M. Dixit Tags: Article Source Type: research
Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint
Mul è et al. provide a framework for integrating human population and single-cell variations to study vaccine responses with and without the adjuvant AS03. They uncover AS03-specific B cell survival and innate-sensing signatures 1 day after vaccination. Furthermore, some AS03-induced response cell st ates are already present at baseline in "naturally adjuvanted" individuals who respond more robustly serologically to the unadjuvanted vaccine. (Source: Immunity)
Source: Immunity - May 1, 2024 Category: Allergy & Immunology Authors: Matthew P. Mul è, Andrew J. Martins, Foo Cheung, Rohit Farmer, Brian A. Sellers, Juan A. Quiel, Arjun Jain, Yuri Kotliarov, Neha Bansal, Jinguo Chen, Pamela L. Schwartzberg, John S. Tsang Tags: Resource Source Type: research
The Role of Macrophage Death in Periodontitis: A Review
This article reviews the typical mechanisms underlying macrophage death and its effects on periodontitis. We describe five forms of macrophage death in periodontitis: apoptosis, pyroptosis, necroptosis, ferroptosis, and ETosis. Our review of macrophage death in the pathophysiology of periodontitis enhances comprehension of the pathogenesis of periodontitis that will be useful for clinical practice. Although our review elucidates the complex mechanisms by which macrophage death and inflammatory pathways perpetuate periodontitis, unresolved issues remain, necessitating further research. (Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
Retraction Note: Geniposide Attenuates LPS-Induced Injury via Up-Regulation of miR-145 in H9c2 Cells
(Source: Inflammation)
Source: Inflammation - May 1, 2024 Category: Allergy & Immunology Source Type: research
Pan-cancer analysis of prognostic and immunological role of IL4I1 in human tumors: a bulk omics research and single cell sequencing validation
ConclusionIL4I1 may play a role as promoter of cancer and prognostic indicator in patients. High expression of IL4I1 is associated with the state of tumor immunosuppression and may contribute to tumor-associated macrophage invasion. Therefore, IL4I1 may be a new therapeutic target for the treatment and prognosis of patients with cancer. (Source: Hormones and Cancer)
Source: Hormones and Cancer - May 1, 2024 Category: Cancer & Oncology Source Type: research
Let us not conflate burn risk and race onto patients with atopic dermatitis
In this issue of the Annals of Allergy, Asthma& Immunology, Alexis et al1 evaluated the efficacy and safety of abrocitinib by race, ethnicity, and Fitzpatrick skin types (FST). This analysis included pooled data from 945 patients older than 12 years who received abrocitinib 200 mg, abrocitinib 100 mg, or placebo from 3 double-blind placebo-controlled atopic dermatitis (AD) trials.1 Race and ethnicity were self-reported. Only data from White (n = 628), Asian (n = 204), and Black (n = 83) patients were analyzed because of low numbers of other racial subgroups, including multiracial patients and those who did not self-report ...
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Kanwaljit K. Brar Tags: Editorial Source Type: research
Primatene mist
I read with interest the article by Ho et al,1 “Cost-effectiveness of budesonide-formoterol vs inhaled epinephrine in US adults with mild asthma.” How interesting to see a cost analysis of using this over-the-counter (OTC) treatment compared with guidelines-based treatment! I agree with the authors that using OTC inhaled epinephrine is not e vidence-based and can be dangerous, even deadly.1,2 Current asthma guidelines suggest using bronchodilator only in conjunction with inhaled corticosteroid.3 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Deborah R. Liptzin Tags: Correspondence Source Type: research
Comment on geographic variation in disease burden among patients with severe persistent asthma in the United States
Asthma affects approximately 25 million individuals in the United States, approximately 20 million of whom are older than 18 years of age.1 These data have traditionally come from self-reporting of diagnosis through national datasets such as the National Health Interview Survey or the National Health and Nutrition Examination Survey. The national health policy for asthma management is often driven by a “one size fits all” approach on the basis of this national prevalence data, an approach that has significant shortcomings as it does not factor in state- and county-level heterogeneity with regard to asthma prevalence, s...
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Rohit K. Katial, Flavia C.L. Hoyte Tags: Editorial Source Type: research
