N4BP1 coordinates ubiquitin-dependent crosstalk within the I κB kinase family to limit Toll-like receptor signaling and inflammation

The ubiquitin-binding endoribonuclease N4BP1 integrates signals from multiple innate immune receptors to regulate inflammatory cytokine responses. Gitlin et  al. find that N4BP1 acts in concert with the noncanonical IκB kinases, TBK1 and IKKε, to suppress late-phase inflammatory gene transcription during Toll-like receptor responses, thereby limiting over-exuberant inflammation.

Source: Immunity - May 1, 2024 Category: Allergy & Immunology Authors: Alexander D. Gitlin, Allie Maltzman, Yuzuka Kanno, Klaus Heger, Rohit Reja, Alexander F. Schubert, Linsey J. Wierciszewski, Homer Pantua, Sharookh B. Kapadia, Seth F. Harris, Joshua D. Webster, Kim Newton, Vishva M. Dixit Tags: Article Source Type: research