Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline
Eur J Pharm Biopharm. 2024 Apr 26:114306. doi: 10.1016/j.ejpb.2024.114306. Online ahead of print.ABSTRACTIn the context of neglected diseases, tegumentary leishmaniasis (TL) presents an emerging and re-emerging character in the national territory and in the world. The treatment of TL has limitations, such as intravenous administration route, high toxicity, and high treatment costs. Thus, several researchers work on new therapeutic strategies to improve the effectiveness of the treatment of leishmaniasis. In this light, the present study used a topical formulation, containing 8-hydroquinoline (8-HQN), for the treatment of B...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 28, 2024 Category: Drugs & Pharmacology Authors: Naianda Rezende Ribeiro Lucas Magno Oliveira Santos Scarleth Silva Costa Carolina Kei Myasaki Daniela Pagliara Lage Vivian Tamietti Martins Rory Cristiane Fortes De Brito Larissa Chaves Freire Ana Maria Ravena Severino Carvalho Bryan Victor Serafim Brigid Source Type: research
Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes
In this study, we reported that, compared to immunogenic splenic DCs of NOD, splenic DCs of NOD.Stat5b-CA mice exhibited a tolerogenic profile marked by elevated PD-L1 and PD-L2 expression, reduced pro-inflammatory cytokine production, increased frequency of the cDC2 subset and decreased frequency of the cDC1 subset. This tolerogenic profile was associated with increased Ezh2 and IRF4 but decreased IRF8 expression. We also found an upregulation of PD-L1 in the cDC1 subset and high PD-L1 and PD-L2 expression in cDC2 of NOD.Stat5b-CA mice. Mechanistically, we demonstrated that Ezh2 plays an important role in the maintenance ...
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Farhan Ullah Khan Puregmaa Khongorzul Denis Gris Abdelaziz Amrani Source Type: research
Dihydroartemisinin inhibits tumor progress via blocking ROR1-induced STAT3-activation in non-small cell lung cancer
In this study, we first proved that DHA prohibits the growth of tumors both in vitro and in vivo. Data from transcriptomics showed that DHA reduced the expression level of the genes involved in cell cycle-promoting and anti-apoptosis, and most importantly, DHA restricted the expression level of receptor tyrosine kinase-like orphan receptor 1 (ROR1) which has been reported to have abnormal expression on tumor cells and had close interaction with STAT3 signaling. Then, we performed comprehensive experiments and found that DHA remarkably decreased the expression of ROR1 at both mRNA and protein levels and it also diminished t...
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Yanping Li Haoyi Sun Caihong Bai Youfan Hu Jingyi Tang Yuxi Zhang Jilan Chen Zhanqiong Zhong Yuping He Kaifeng Hu Jiahui Yang Source Type: research
Identification and functional analysis of the hub Ferroptosis-Related gene EZH2 in diabetic kidney disease
CONCLUSION: Overall, our data shouwed that histone H3K27 methyltransferase EZH2 could regulate the renal tubular epithelial cell ferroptosis by suppressing SLC7A11 in DKD, which may serve as a credible reliable indicator for diagnosing DKD and a potential target for treatment.PMID:38678670 | DOI:10.1016/j.intimp.2024.112138 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Han Wang Jiajia Wang Qingsen Ran Yan Leng Tiejun Liu Zhuang Xiong Dixin Zou Weipeng Yang Source Type: research
Verapamil and tangeretin enhances the M1 macrophages to M2 type in lipopolysaccharide-treated mice and inhibits the P-glycoprotein expression by downregulating STAT1/STAT3 and upregulating SOCS3
Int Immunopharmacol. 2024 Apr 26;133:112153. doi: 10.1016/j.intimp.2024.112153. Online ahead of print.ABSTRACTLPS induced sepsis is a complex process involving various immune cells and signaling molecules. Dysregulation of macrophage polarization and ROS production contributed to the pathogenesis of sepsis. PGP is a transmembrane transporter responsible for the efflux of a number of drugs and also expressed in murine macrophages. Natural products have been shown to decrease inflammation and expression of efflux transporters. However, no treatment is currently available to treat LPS induced sepsis. Verapamil and Tangeretin ...
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Ayantika Kundu Pratiti Ghosh Biswadev Bishayi Source Type: research
Manual acupuncture ameliorates inflammatory pain by upregulating adenosine A < sub > 3 < /sub > receptor in complete Freund's adjuvant-induced arthritis rats
CONCLUSION: MA can alleviate inflammatory pain by inhibiting the NF-κB signaling pathway via upregulating A3R expression of the superficial fascia of the ST36 acupoint site in CFA-induced arthritis rats.PMID:38678668 | DOI:10.1016/j.intimp.2024.112095 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Jing-Ping Xu Qian-Wen Ouyang Mei-Juan Shao Hong Ke Hong Du Shang-Cheng Xu Qian Yang Yan-Ru Cui Fei Qu Source Type: research
BMAL1 alleviates myocardial damage in sepsis by activating SIRT1 signaling and promoting mitochondrial autophagy
CONCLUSION: BMAL1 enhances mitophagy dependent on SIRT1, thereby alleviating myocardial injury in sepsis.PMID:38678672 | DOI:10.1016/j.intimp.2024.112111 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Wen Tang Rennan Guo Congyu Hu Yang Yang Danping Yang Xiaxia Chen Yan Liu Source Type: research
Association between Covishield vaccine and menstrual disturbance. Findings from a cross-sectional study among participants of Zero TB cohort in India
CONCLUSION: Menstrual problems were reported by Covishield vaccinees, but they were minor and reversible within three months and do not constitute a ground for vaccine hesitancy. Studies designed to assess causal link taking care to avoid selection bias or confounding are needed.PMID:38679512 | DOI:10.1016/j.vaccine.2024.04.063 (Source: Vaccine)
Source: Vaccine - April 28, 2024 Category: Allergy & Immunology Authors: Kunchok Dorjee Tenzin Namdon Sonam Topgyal Ugen Gyatso Tenzin Tsundue Tashi Dolma Vipan Kumar Dekyi Lhadon Tenzin Yangkyi Tenzin Khachoe Sangyal Dorjee R C Sadoff David Peters Amita Gupta Zorba Paster Richard E Chaisson Dawa Phunkyi Tsetan D Sadutshang Source Type: research
Collective good and individual choice: Perceptions on COVID-19 vaccine mandate among COVID-19 vaccinated individuals
CONCLUSION: Support for a COVID-19 vaccination mandate is controversial even among vaccinated people. Identifying and understanding cultural and contextual factors that underlie differences in attitudes and beliefs about COVID-19 vaccination mandates is essential to advance dialogue and inform educational health campaigns to increase COVID-19 vaccination rates.PMID:38679513 | DOI:10.1016/j.vaccine.2024.04.052 (Source: Vaccine)
Source: Vaccine - April 28, 2024 Category: Allergy & Immunology Authors: Kaivalya Gudooru Kimberly Nguyen Kathy Le Vyas Sarabu Meredith Hosek Anna Phan Michelle Garza Bertha E Flores Armida Flores Amelie Ramirez Luz M Garcini Source Type: research
Low-dose metformin suppresses hepatocellular carcinoma metastasis via the AMPK/JNK/IL-8 pathway
CONCLUSION: The results indicate that low-dose metformin can inhibit HCC metastasis by suppressing IL-8 expression. Targeting the AMPK/JNK/IL-8 axis may be a promising treatment strategy for patients with HCC metastasis.PMID:38679570 | PMC:PMC11057349 | DOI:10.1177/03946320241249445 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 28, 2024 Category: Allergy & Immunology Authors: Chengwen Zhao Lu Zheng Yuting Ma Yue Zhang Chanjuan Yue Feng Gu Guoping Niu Yongqiang Chen Source Type: research
The Future of Therapeutic Options for Hereditary Angioedema
Ann Allergy Asthma Immunol. 2024 Apr 26:S1081-1206(24)00275-8. doi: 10.1016/j.anai.2024.04.029. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare, genetic condition causing unpredictable and severe episodes of angioedema that are debilitating and life-threatening. HAE can be classified into HAE due to C1INH deficiency (HAE-C1INH), or HAE with normal C1INH (HAE-nl-C1INH). HAE-C1INH is subcategorized as type I and II based upon deficient or dysfunctional circulating C1INH protein resulting from inherited or spontaneous mutations in the SERPING1 gene leading to uncontrolled Factor XII(FXII)/plasma kallikrein...
Source: Annals of Allergy, Asthma and Immunology - April 28, 2024 Category: Allergy & Immunology Authors: Tukisa D Smith Marc A Riedl Source Type: research
Levels of Immunoglobulin E Sensitization Drive Symptom Thresholds in Allergic Rhinitis
CONCLUSION: With increasing number of sensitizations, AR patients experience an increased diversity of symptoms. Multimorbidity-related symptoms increase with sensitization rank, suggesting organ-specific thresholds.PMID:38679157 | DOI:10.1016/j.anai.2024.04.026 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - April 28, 2024 Category: Allergy & Immunology Authors: Maria V Dimou Paraskevi Xepapadaki John Lakoumentas Leonardos Mageiros Xenophon Aggelidis Maria Antonopoulou Petros Bakakos Sophia Βotskariova Konstantinos Chliveros Spyridon Chrysoulakis Dionysios Dimas Nikolaos Douladiris Mina Gaga Christos Grigoreas L Source Type: research
PD-BAT: A novel approach of pooling basophil donors for expansion of commercial laboratory testing of Chronic Spontaneous Urticaria
In this study, we introduce an innovative approach where multiple potential basophil donors undergo rigorous BAT characterization alongside control samples. By selecting and pooling donors with optimal performance, we significantly enhance the inter-assay reproducibility of the indirect BAT test.PMID:38679364 | DOI:10.1016/j.jim.2024.113679 (Source: Journal of Immunological Methods)
Source: Journal of Immunological Methods - April 28, 2024 Category: Allergy & Immunology Authors: Saintedym Wills Jessica Chavez Ajay Grover Nathanael Beck Michele Romano Christina Bauer Michael Gerspach Michael Schneider Andre Valcour Source Type: research
Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights
Int J Hyperthermia. 2024;41(1):2336149. doi: 10.1080/02656736.2024.2336149. Epub 2024 Apr 28.ABSTRACTHeat shock proteins (HSP) have been associated with a range of persistent inflammatory disorders; however, little research has been conducted on the involvement of HSP in the development of ankylosing spondylitis (AS). The research aims to identify a diagnostic signature based on HSP-related genes and determine the molecular subtypes of AS. We gathered the transcriptional data of patients with AS from the GSE73754 dataset and conducted a literature search for HSP-related genes (HRGs). The logistic regression model was utili...
Source: International Journal of Hyperthermia - April 28, 2024 Category: Internal Medicine Authors: Geqiang Wang Yongji Li Jiaxing Liu Qian Zhang Weixin Cai Xiaodong Li Source Type: research
Effect of exposure to disinfection by-products during swimming exercise on asthma-related immune responses
In this study, we investigated the influence of swimming exercise and DBPs on asthma. The decomposition products had little effect on the number of T cells in various immune organs. However, swimming exercise was found to increase the cell count in proportion to the exercise duration. Nevertheless, there were no significant changes in other immune cells and the secretion of asthma-related cytokines. These findings indicate that the effects of swimming pool DBPs on respiratory conditions during swimming exercise are either negligible or absent, and instead, the immunological benefits gained through consistent swimming exerc...
Source: Journal of Water and Health - April 28, 2024 Category: Environmental Health Authors: Bo-Ae Lee Source Type: research
