FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research
The immune cells in modulating osteoclast formation and bone metabolism
Int Immunopharmacol. 2024 Apr 28;133:112151. doi: 10.1016/j.intimp.2024.112151. Online ahead of print.ABSTRACTOsteoclasts are pivotal in regulating bone metabolism, with immune cells significantly influencing both physiological and pathological processes by modulating osteoclast functions. This is particularly evident in conditions of inflammatory bone resorption, such as rheumatoid arthritis and periodontitis. This review summarizes and comprehensively analyzes the research progress on the regulation of osteoclast formation by immune cells, aiming to unveil the underlying mechanisms and pathways through which diseases, su...
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Jiale Hong Fang Luo Xingyue Du Fa Xian Xinyi Li Source Type: research
Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands by medical risk condition: A test-negative case-control study
CONCLUSION: Although VE against hospitalization was 78% and increased to 89% after boosting during the Delta-dominant study period, VE was lower in certain high risk groups, for which indirect protection or other protective measures might be of added importance.PMID:38688804 | DOI:10.1016/j.vaccine.2024.04.017 (Source: Vaccine)
Source: Vaccine - April 30, 2024 Category: Allergy & Immunology Authors: F A Niessen P C J L Bruijning-Verhagen M J M Bonten VECTOR study group M J Knol Source Type: research
Effects of parental childhood cultural health environment on children's influenza and COVID-19 vaccination status
We examined whether the childhood cultural health environment (CHE) of parents (measured by self-reported regular attendance at doctor and dentist visits during childhood) was associated with flu and COVID-19 vaccination of their children. Using 2023 survey data from 397 US parents and causal inference methods, we estimated the average causal effect of parental CHE on flu vaccination rates (0.16 [95 % confidence interval: 0.06,0.27]) and COVID-19 (0.14 [95 % confidence interval: 0.04,0.24]), indicating that if all parents had attended regular doctor/dentist visits as children, flu and COVID-19 vaccination rates in children...
Source: Vaccine - April 30, 2024 Category: Allergy & Immunology Authors: Sasha A Fleary Zachary Shahn Chloe A Teasdale Source Type: research
Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion
CONCLUSION: This thesis explored the role of NCOA4 in II/R injury in mice and the mechanism of action. The research results suggest that NCOA4 can mediate ferritinophagy to induce ferroptosis during II/R injury. This experiment reveals the pathological mechanism of II/R injury and provides some scientific basis for the development of drugs for the treatment of II/R injury based on the purpose of alleviating ferroptosis.PMID:38688134 | DOI:10.1016/j.intimp.2024.112155 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Kun Li Annan Wang Yunpeng Diao Shuyuan Fan Source Type: research
Targeting pyroptosis to treat ischemic stroke: From molecular pathways to treatment strategy
Int Immunopharmacol. 2024 Apr 29;133:112168. doi: 10.1016/j.intimp.2024.112168. Online ahead of print.ABSTRACTIschemic stroke is the primary reason for human disability and death, but the available treatment options are limited. Hence, it is imperative to explore novel and efficient therapies. In recent years, pyroptosis (a pro-inflammatory cell death characterized by inflammation) has emerged as an important pathological mechanism in ischemic stroke that can cause cell death through plasma membrane rupture and release of inflammatory cytokines. Pyroptosis is closely associated with inflammation, which exacerbates the infl...
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Lina Li Chonglin Shi Fang Dong Guangyu Xu Mingcheng Lei Feng Zhang Source Type: research
Association of pathological response with long-term survival outcomes after neoadjuvant immunotherapy: A meta-analysis
CONCLUSION: Our meta-analysis demonstrates a strong association between pathological response and long-term survival outcomes at patient level across studies applying neoadjuvant immunotherapy in most solid tumors but we fail to validate the relationship at trial level. Therefore, an accepted surrogate endpoint applied to both patient and trial levels are waited for further search.PMID:38685176 | DOI:10.1016/j.intimp.2024.112078 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Chenyu Wei Haolin Sun Jiexuan Hu Zhongjun Ma Bangwei Cao Source Type: research
Early response to Tezepelumab in type-2 severe asthma patients non-responders to other biological treatments: a real-life study
CONCLUSION. In real-world scenarios, despite the study's limitations, our results underscore Tezepelumab's promise as a therapeutic option for uncontrolled severe asthma, and may be useful for non-responders to other mAbs. Further studies are needed to corroborate these findings.PMID:38686823 | DOI:10.1080/02770903.2024.2349605 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Miguel Jim énez-Gómez Roc ío Magdalena Díaz-Campos Álvaro Gimeno-Díaz-De-Atauri Consuelo Fern ández-Rodríguez Jes ús Fernández-Crespo Ismael Garc ía-Moguel Source Type: research
A Meta-Analysis Investigating the Efficacy and Safety of Allergen-Specific Immunotherapy in the Management of Respiratory Allergies
Conclusion: The results of our meta-analysis suggest that specific immunotherapy, while associated with some adverse effects, effectively reduces the symptoms of asthma and rhinitis. Therefore, we recommend its use in the treatment of respiratory allergies.PMID:38687911 | DOI:10.1080/02770903.2024.2349604 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Xue Li Juju Shang Jian Liu Yong Zhu Source Type: research
Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis
Conclusion This work provided a machine learning model containing five important variables, which may have good diagnostic efficiency for pediatric AA.PMID:38687912 | DOI:10.1080/02770903.2024.2349596 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Jingping Liu Yujia Sun Chunxin Tian Dong Qin Lanying Gao Source Type: research
Diagnostic Accuracy of Conjunctival Rt-Pcr in Sars-Cov-2: A Systematic Review and Diagnostic Accuracy Meta-Analysis
CONCLUSIONS: Only 1 in 10 RT-PCR tests performed on conjunctival swabs were positive for SARS-CoV-2. Although this suggests that SARS-CoV-2 is likely present and detectable in the conjunctiva, this detection method has low diagnostic potential.PMID:38687292 | DOI:10.1080/09273948.2023.2272200 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 30, 2024 Category: Allergy & Immunology Authors: A Faubert R Bohsina E You M H ébert M Griffith M J Aubin Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
GC-MS and ATR-FTIR Spectroscopy Coupled with Chemometric Analysis for Detection and Quantification of White Turmeric ( < em > Curcuma zedoaria < /em > ) Essential Oils Adulteration
Conclusion:</b> The FTIR and chemometrics combination effectively authenticates white turmeric essential oil from any possible adulterants, such as vegetable oil.PMID:38686738 | DOI:10.3923/pjbs.2024.160.167 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Suryati Syafri Ghada Nabila Gari Lindo Yohannes Alen Syofyan Syofyan Dachriyanus Hamidi Source Type: research
Endoscopic treatment of an esophageal perforation in eosinophilic esophagitis by insertion of a self-expanding metal stent
We present the case of a 29-year-old patient with multiple allergies, mild asthma and rhinoconjunctivitis who reported a history of esophageal impactions after ingestion of solid foods. These episodes resolved spontaneously at home and by self-induced vomiting and never required endoscopic removal. The patient presented to the emergency department due to a sensation of food impaction lasting more than 12 hours after eating meat the night before, which did not subside with the intake of liquids or self-induced vomiting. Endoscopic evaluation was requested for foreign body extraction. A meat bolus impacted in the distal esop...
Source: Revista Espanola de Enfermedades Digestivas - April 30, 2024 Category: Gastroenterology Authors: Mar ía Belén López Moreno V íctor Jiménez Beltrán Mar ía Antonia Godoy López Jes ús García-Cano Source Type: research
