Poor vaccine-related immunity against HBV in children with autoimmune diseases: Early or late sign of immunological disorder?
PMID: 30992122 [PubMed - in process] (Source: Vaccine)
Source: Vaccine - April 19, 2019 Category: Allergy & Immunology Authors: Antonucci R, Frassetto R, Vacca N, Mura D, Lampis R, Castiglia P, Sotgiu G, Piana A, Clemente MG Tags: Vaccine Source Type: research
Antigen specific vaccine hesitancy in pregnancy.
DISCUSSION: While maternal pertussis vaccine programs are a success, work needs to be done to improve the public perception of the risk benefit equation surrounding influenza vaccine in general, and particularly its use in pregnancy. Research is required into approaches to altering practitioner attitudes as well as how to alter public perceptions. PMID: 30992221 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 13, 2019 Category: Allergy & Immunology Authors: Van Buynder PG, Van Buynder JL, Menton L, Thompson G, Sun J Tags: Vaccine Source Type: research
Hepatitis A incidence, seroprevalence, and vaccination decision among MSM in Amsterdam, the Netherlands.
Abstract BACKGROUND: Several outbreaks of Hepatitis A virus (HAV) were recently documented among men who have sex with men (MSM) in Europe. We investigated the HAV incidence among MSM in Amsterdam, the Netherlands; and HAV seroprevalence and HAV vaccination decision among MSM visiting the Sexually Transmitted Infection (STI) clinic in Amsterdam. METHODS: Using surveillance data from 1992 to 2017 of MSM with acute HAV in Amsterdam, we estimated the incidence by calendar year and age. We explored HAV seroprevalence by calendar year and age, determinants for HAV seropositivity, and opting-in/out for HAV vaccinat...
Source: Vaccine - April 13, 2019 Category: Allergy & Immunology Authors: Alberts CJ, Boyd A, Bruisten SM, Heijman T, Hogewoning A, Rooijen MV, Siedenburg E, Sonder GJB Tags: Vaccine Source Type: research
Case fatality rates of invasive meningococcal disease by serogroup and age: A systematic review and meta-analysis.
CONCLUSIONS: Our findings can provide useful information for better understanding the mortality risks, and quantifying the burden associated with IMD mortality. PMID: 30987851 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 13, 2019 Category: Allergy & Immunology Authors: Wang B, Santoreneos R, Giles L, Haji Ali Afzali H, Marshall H Tags: Vaccine Source Type: research
STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice.
CONCLUSIONS: Our results illustrate that the innate immune pathway targeted by adjuvants can critically impact the outcome of the immune response post-vaccination. Specifically, CDN stimulation of APCs induced an activation phenotype that was characterized by decreased innate effector molecule production (e.g., NO) and increased BAFF. This was attributed to the induction of an innate inflammatory environment that enabled the host to make the most of the existing B lymphocyte potential. The use of adjuvants that differentially engage mechanisms of innate immune activation would be particularly advantageous for the generatio...
Source: Vaccine - April 12, 2019 Category: Allergy & Immunology Authors: Darling RJ, Senapati S, Kelly SM, Kohut ML, Narasimhan B, Wannemuehler MJ Tags: Vaccine Source Type: research
Safety and immunogenicity of a respiratory syncytial virus fusion glycoprotein F subunit vaccine in healthy adults: Results of a phase 1, randomized, observer-blind, controlled, dosage-escalation study.
CONCLUSIONS: A single dose of each formulation of RSV subunit F vaccine was well-tolerated and enhanced preexisting NAb titers through six months of follow-up. PMID: 30987852 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 12, 2019 Category: Allergy & Immunology Authors: Leroux-Roels G, De Boever F, Maes C, Nguyen TL, Baker S, Gonzalez Lopez A Tags: Vaccine Source Type: research
Trends and spatial distribution of MMR vaccine coverage in Brazil during 2007-2017.
em DB Abstract We analyzed the time trends and spatial distribution of MMR vaccine coverage in Brazil during 2007-2017. In early 2018, a measles outbreak started in the North region of Brazil, reaching 11 of the 27 federal units by January 24, 2019. In this period, 10,302 cases were confirmed. Although the reintroduction of measles in Brazil is likely due to migration from Venezuela, the spread of the virus was made possible by the low levels of MMR coverage, as a result of significant decreases during the study period. Areas with high concentration of municipalities with low coverage are more susceptible to the s...
Source: Vaccine - April 12, 2019 Category: Allergy & Immunology Authors: Pacheco FC, França GVA, Elidio GA, Domingues CMAS, de Oliveira C, Guilhem DB Tags: Vaccine Source Type: research
The comparative efficacy and safety of herpes zoster vaccines: A network meta-analysis.
CONCLUSION: RZV is significantly more effective in reducing HZ and PHN incidence in adults ≥60 YOA, compared with ZVL. As anticipated with an adjuvanted vaccine, RZV results in more reactogenicity following immunization. No differences in SAEs were found between RZV and ZVL. PMID: 30982636 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 11, 2019 Category: Allergy & Immunology Authors: McGirr A, Widenmaier R, Curran D, Espié E, Mrkvan T, Oostvogels L, Simone B, McElhaney JE, Burnett H, Haeussler K, Thano A, Wang X, Newson RS Tags: Vaccine Source Type: research
Response to a reinforced hepatitis B vaccination scheme in HIV-infected patients under real-life conditions.
CONCLUSION: Accelerated administration of three double-doses results in considerable high, however still suboptimal, response rates to HBV-V in HIV-infected patients in the clinical practice. A fourth dose should be considered. PMID: 30981625 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 10, 2019 Category: Allergy & Immunology Authors: Neukam K, Gutiérrez-Valencia A, Llaves-Flores S, Espinosa N, Viciana P, López-Cortés LF Tags: Vaccine Source Type: research
Clinical endpoints for efficacy studies.
Abstract Well-established, validated and clinically meaningful primary and secondary endpoints are critical in advancing vaccines through proof of principal studies, licensure and pre-qualification. To that end, the field of vaccine development for Shigella, enterotoxigenic Escherichia coli (ETEC) as well as other enteric pathogens would benefit greatly from a focused review of clinical endpoints and the use of common endpoints across the field to enable study-to-study comparisons as well as comparative assessments between vaccine candidates. A workshop was conducted to review clinical endpoints from controlled hu...
Source: Vaccine - April 10, 2019 Category: Allergy & Immunology Authors: Porter CK, Gutierrez RL, Kotloff KL Tags: Vaccine Source Type: research
Significant impact of pneumococcal conjugate vaccination on pediatric parapneumonic effusion: Italy 2006-2018.
Abstract Etiology and serotyping of parapneumonic effusion (PPE) and the impact of vaccination was evaluated over a 12-year period, before and after the PCV13 introduction (2011) for Italian children From 0 to 16 years of age. Five hundred and two children were evaluated; 226 blood and 356 pleural fluid samples were obtained and tested using Realtime-PCR and culture. In the pre-PCV13 era S. pneumoniae was the most frequent pathogen identified (64/90; 71.1%) with a large predominance of serotypes 1 (42.4%), 3 (23.7%), 7F (5.1%) and 19A (11.9%). The impact of vaccination, calculated on children 0-8 years of age,...
Source: Vaccine - April 10, 2019 Category: Allergy & Immunology Authors: Azzari C, Serranti D, Nieddu F, Moriondo M, Casini A, Lodi L, de Benedictis FM, De Vitis E, Cavone F, Cortimiglia M, Indolfi G, Lombardi E, Carloni I, Cutrera R, Lucenteforte E, Resti M, Ricci S Tags: Vaccine Source Type: research
Improving access to affordable vaccines for middle-income countries in the african region.
Abstract Despite the remarkable power of immunization reducing morbidity and mortality due to vaccine preventable diseases, one in five African children still does not receive all the basic, necessary vaccines. This is particularly true of the 10 middle-income countries (MICs) in the WHO African Region, where data demonstrates that immunization coverage is decreasing. These countries are not eligible for Gavi support in accessing new vaccines because of their relatively high per capita income level and will gradually increase with the transitioning of countries out of Gavi support. Thus, WHO was requested to facil...
Source: Vaccine - April 9, 2019 Category: Allergy & Immunology Authors: Mihigo R, Okeibunor J, Cernuschi T, Petu A, Satoulou A, Zawaira F Tags: Vaccine Source Type: research
BTV antibody longevity in cattle five to eight years post BTV-8 vaccination.
Abstract The Bluetongue virus serotype -8 (BTV-8) epizootic in Germany (2006-2008) was successfully eradicated, essentially by the massive application of commercially available inactivated BTV-8 vaccines. While a six-year antibody longevity of BTV antibodies post BTV-8 vaccination in cattle has been described previously, our study investigated the BTV-8-vaccine antibodies in cattle for up to eight years. In total, 157 bovine serum samples were analysed for the presence of group-specific BTV antibodies in both a commercial cELISA, and a BTV-8- specific serum neutralization test. A robust number of cattle were serop...
Source: Vaccine - April 9, 2019 Category: Allergy & Immunology Authors: Ries C, Beer M, Hoffmann B Tags: Vaccine Source Type: research
A qualitative study of vaccination behaviour amongst female Polish migrants in Edinburgh, Scotland.
Abstract Vaccine hesitancy is increasing and failure to vaccinate is well-recognised in Europe as a contributing factor to outbreaks of infectious diseases. In Lothian and Scotland, low vaccine uptake has been seen in migrants - notably in the Polish group who have arrived since 2004. The recent Vaccine Confidence in European Union report highlights a concerning recent decline in vaccine confidence in Poland. We held three focus groups containing 13 Polish women about the childhood vaccination programme in Lothian, with specific focus on influenza and Human Papillomavirus vaccinations. Key emergent themes were: tr...
Source: Vaccine - April 9, 2019 Category: Allergy & Immunology Authors: Gorman DR, Bielecki K, Willocks LJ, Pollock KG Tags: Vaccine Source Type: research
Lessons for general vaccinology research from attempts to develop an HIV vaccine.
Abstract In the past when large investments have been made in tackling narrow scientific challenges, the enormous expansion in our knowledge in one small area has had a spill-over effect on research and treatment of other diseases. The large investment in HIV vaccine development in recent years has the potential for such an effect on vaccine development for other diseases. HIV vaccine developers have experienced repeated failure using the standard approaches to vaccine development. This has forced them to consider immune responses in greater depth and detail. It has led to a recognition of the importance of epitop...
Source: Vaccine - April 9, 2019 Category: Allergy & Immunology Authors: Shapiro SZ Tags: Vaccine Source Type: research
Determinants of satisfaction with information and additional information-seeking behaviour for the pertussis vaccination given during pregnancy.
CONCLUSIONS: We found that high trust in health care professionals, a perceived ability to seek out accurate information about vaccines and actively focusing on problems as a means of coping with stress, drives satisfaction in official vaccine information. We also developed measures of these variables that could be used in further research. PMID: 30975566 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 8, 2019 Category: Allergy & Immunology Authors: Clarke RM, Paterson P, Sirota M Tags: Vaccine Source Type: research
An ODE-based mixed modelling approach for B- and T-cell dynamics induced by Varicella-Zoster Virus vaccines in adults shows higher T-cell proliferation with Shingrix than with Varilrix.
Abstract Clinical trials covering the immunogenicity of a vaccine aim to study the longitudinal dynamics of certain immune cells after vaccination. The corresponding immunogenicity datasets are mainly analyzed by the use of statistical (mixed effects) models. This paper proposes the use of mathematical ordinary differential equation (ODE) models, combined with a mixed effects approach. ODE models are capable of translating underlying immunological post vaccination processes into mathematical formulas thereby enabling a testable data analysis. Mixed models include both population-averaged parameters (fixed effects)...
Source: Vaccine - April 8, 2019 Category: Allergy & Immunology Authors: Keersmaekers N, Ogunjimi B, Van Damme P, Beutels P, Hens N Tags: Vaccine Source Type: research
Influenza in Latin America: A report from the Global Influenza Initiative (GII).
This article provides a consolidated estimation of disease burden in Latin America, currently lacking in published literature, and delivers the GII recommendations specific to Latin America that provide guidance to combat existing vaccination challenges. While many countries worldwide, especially in the tropics and subtropics, do not have a seasonal influenza policy, 90% of Latin American countries have a seasonal influenza policy in place. Local governments in the Latin American countries and The Pan American Health Organization's Technical Advisory Group on Vaccine-preventable Diseases play a major role in improving the ...
Source: Vaccine - April 8, 2019 Category: Allergy & Immunology Authors: Gentile A, Paget J, Bellei N, Torres JP, Vazquez C, Laguna-Torres VA, Plotkin S, GII Tags: Vaccine Source Type: research
Impact of the pediatric 13-valent pneumococcal conjugate vaccine on serotype distribution and clinical characteristics of pneumococcal pneumonia in adults: The Japan Pneumococcal Vaccine Effectiveness Study (J-PAVE).
Abstract BACKGROUND: The pediatric 13-valent pneumococcal conjugate vaccine (PCV13) was included in the pediatric immunization programme in Japan in late 2013. The impact of vaccination on the serotype distribution and clinical characteristics of pneumococcal pneumonia has not been described. METHODS: The first phase of this multicentre prospective study was conducted at community-based hospitals in Japan from 2011 to 2014. The second phase was conducted from 2016 to 2017. Pneumococcal isolates and clinical data were collected from patients with community-acquired pneumonia who were ≥15 years of age. Pat...
Source: Vaccine - April 8, 2019 Category: Allergy & Immunology Authors: Sando E, Suzuki M, Furumoto A, Asoh N, Yaegashi M, Aoshima M, Ishida M, Hamaguchi S, Otsuka Y, Morimoto K Tags: Vaccine Source Type: research
Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines - A phase II, randomised, observer-blind study in Gambian infants.
CONCLUSION: Immune responses to the 10 PHiD-CV polysaccharide conjugates and co-administered vaccines were not altered by addition of dPly and PhtD. ClinicalTrials.gov identifier NCT01262872. PMID: 30975570 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 8, 2019 Category: Allergy & Immunology Authors: Odutola A, Ota MOC, Antonio M, Ogundare EO, Saidu Y, Owiafe PK, Worwui A, Idoko OT, Owolabi O, Kampmann B, Greenwood BM, Alderson M, Traskine M, Swinnen K, Verlant V, Dobbelaere K, Borys D Tags: Vaccine Source Type: research
Pertussis vaccine effectiveness in a frequency matched population-based case-control Canadian Immunization Research Network study in Ontario, Canada 2009-2015.
CONCLUSIONS: VE is high during the first decade of life but then falls rapidly. Protection is not fully restored by the teenage booster. Our findings are consistent with the localized outbreaks we observe in high school children and underline the importance of additional policies to protect infants. PMID: 30967309 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 6, 2019 Category: Allergy & Immunology Authors: Crowcroft NS, Schwartz KL, Chen C, Johnson C, Li Y, Marchand-Austin A, Bolotin S, Jamieson FB, Drews SJ, Russell ML, Svenson LW, Simmonds K, Mahmud SM, Kwong JC Tags: Vaccine Source Type: research
Immunogenicity and protection conferred by an optimized purified inactivated Zika vaccine in mice.
Abstract After decades of inconsequential infections, and sporadic outbreaks in the Asia-Pacific region between 2007 and 2013, Zika virus caused a widespread epidemic in South America in 2015 that was complicated by severe congenital infections. After the WHO declared a Public Health Emergency of International Concern in February 2016, vaccine development efforts based on different platforms were initiated. Several candidates have since been evaluated in clinical phase I studies. Of these, a Zika purified inactivated vaccine (ZPIV), adjuvanted with aluminum hydroxide, developed by the Walter Reed Army Institute of...
Source: Vaccine - April 6, 2019 Category: Allergy & Immunology Authors: Lecouturier V, Bernard MC, Berry C, Carayol S, Richier E, Boudet F, Heinrichs J Tags: Vaccine Source Type: research
Vaccine-preventable diseases and immunisation coverage among migrants and non-migrants worldwide: A scoping review of published literature, 2006 to 2016.
CONCLUSIONS: Considerable variability of study foci and methodologies limited our ability to make definitive conclusions and comparisons, but the literature suggests that migrant populations generally experience higher VPD burden and lower immunisation rates. The findings highlight a number of important considerations for future research and immunisation programme planning. Future research should explore factors that influence VPD burden and immunisation rates, and strategies to overcome barriers to vaccine uptake among migrants. PMID: 30967311 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 6, 2019 Category: Allergy & Immunology Authors: Charania NA, Gaze N, Kung JY, Brooks S Tags: Vaccine Source Type: research
On the contextual nature of vaccine safety monitoring: Adverse events reporting after HPV-vaccination in Denmark, 2015.
sh;lbak K Abstract BACKGROUND: In 2013-15, Denmark experienced an increase in reported suspected adverse events following vaccination (AEFI) against human papilloma virus (HPV). Dedicated centres ("One Access") were established in order to standardize management of patients who experienced medically unexplained physical symptoms after HPV vaccination. Since One Access was targeted patients with suspected AEFI after HPV vaccination, we used this opportunity to estimate completeness in AEFI reporting to the Danish Medicines Agency (DMA), and explore the topic of AEFI reporting from the perspective of physi...
Source: Vaccine - April 6, 2019 Category: Allergy & Immunology Authors: Schartau S, Heering Holt D, Lützen T, Rytter D, Mølbak K Tags: Vaccine Source Type: research
Modeling indicates efficient vaccine-based interventions for the elimination of hepatitis C virus among persons who inject drugs in metropolitan Chicago.
CONCLUSIONS: The modeling results underscore the importance of developing an effective HCV vaccine and augmenting DAAs with vaccines in HCV intervention strategies in order to achieve efficient reductions in incidence and prevalence. PMID: 30962092 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 5, 2019 Category: Allergy & Immunology Authors: Echevarria D, Gutfraind A, Boodram B, Layden J, Ozik J, Page K, Cotler SJ, Major M, Dahari H Tags: Vaccine Source Type: research
Development and acceptability of a video-based vaccine promotion tutorial for obstetric care providers.
Abstract A prenatal care provider's recommendation for maternal vaccines is one of the strongest predictors of vaccine acceptance during pregnancy. Aside from basic talking points, few resources exist to help obstetric care providers effectively navigate conversations with vaccine hesitant patients. This paper describes the development and acceptability of "VaxChat," an hour-long, evidence-based video tutorial aimed at improving obstetric care providers' ability to promote maternal vaccines. Between June and November 2017, 62 obstetric care providers registered to receive continuing medical education cre...
Source: Vaccine - April 5, 2019 Category: Allergy & Immunology Authors: Chamberlain AT, Limaye RJ, O'Leary ST, Frew PM, Brewer SE, Spina CI, Ellingson MK, Dudley MZ, Orenstein WA, Donnelly MA, Riley LE, Ault KA, Salmon DA, Omer SB Tags: Vaccine Source Type: research
Persistence of the immune response after vaccination with the Japanese encephalitis vaccine, IXIARO ® in healthy adults: A five year follow-up study.
Persistence of the immune response after vaccination with the Japanese encephalitis vaccine, IXIARO® in healthy adults: A five year follow-up study. Vaccine. 2019 Apr 05;: Authors: Taucher C, Kollaritsch H, Dubischar KL Abstract Immunization with the Japanese encephalitis (JE) vaccine IXIARO® results in protective neutralizing antibody levels for one year. Since persistence of protective titer levels beyond one year was unknown, a 5 years follow-up study was conducted. Additionally, data were stratified to compare the persistence of protective neutralizing antibodies against JE in people wit...
Source: Vaccine - April 5, 2019 Category: Allergy & Immunology Authors: Taucher C, Kollaritsch H, Dubischar KL Tags: Vaccine Source Type: research
A phase 1 randomized study assessing safety and immunogenicity of two 3-dose regimens of a Clostridium difficile vaccine in healthy older Japanese adults.
CONCLUSIONS: The C difficile vaccine candidate was safe, well tolerated, and immunogenic when administered to healthy older Japanese adults at 0, 1, and 6 months. Results support continued development of the vaccine for the prevention of CDI. ClinicalTrials.gov identifier: NCT02725437. PMID: 30962095 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 5, 2019 Category: Allergy & Immunology Authors: Inoue M, Yonemura T, de Solom R, Yamaji M, Aizawa M, Knirsch C, Pride MW, Jansen KU, Gruber W, Webber C Tags: Vaccine Source Type: research
Acquisition of specific antibodies and their influence on cell-mediated immune response in neonatal cord blood after maternal pertussis vaccination during pregnancy.
In this study, we evaluated neonatal passive acquisition of pertussis-specific antibodies and their influence on the neonatal cell-mediated immune response. Pregnant women were either vaccinated with Tdap vaccine (case group, n = 66) or received no vaccine (control group, n = 101). Whole-cell Bordetella pertussis (Bp), pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN)-specific serum IgG were quantified in paired maternal-cord sera, and Bp- and PT-specific IgA were evaluated in colostrum by ELISA. Ex vivo neonatal blood lymphocyte responsiveness after Bp stimulation was assessed in case (n ...
Source: Vaccine - April 4, 2019 Category: Allergy & Immunology Authors: Lima L, Molina MDGF, Pereira BS, Nadaf MLA, Nadaf MIV, Takano OA, Carneiro-Sampaio M, Palmeira P Tags: Vaccine Source Type: research
Targeting M2e to DEC-205 induces an enhanced serum antibody-dependent heterosubtypic protection against influenza A virus infection.
Abstract The ectodomain of the influenza A virus (IAV) M2 protein (M2e) is highly conserved, and it represents a promising candidate for the development of an "universal vaccine". However, the low immunogenicity associated to M2e in a natural infection or in response to seasonal vaccines has led to explore new approaches to enhance it. In recent years, it has become clear that targeting antigens to dendritic cells (DC) is an efficient way to enhance immune responses against pathogens. In this work, the M2e peptide was chemically cross-linked to a monoclonal antibody (mAb) specific for DEC-205 (α-DE...
Source: Vaccine - April 4, 2019 Category: Allergy & Immunology Authors: Padilla-Quirarte HO, Badillo-Godinez O, Gutierrez-Xicotencatl L, Acevedo-Betancur Y, Luna-Andon JD, Montiel-Hernandez JL, Lopez-Guerrero DV, Esquivel-Guadarrama F Tags: Vaccine Source Type: research
Safety and immunogenicity of an 8 year interval heterologous prime-boost influenza A/H7N7-H7N9 vaccination.
CONCLUSIONS: Priming with IIV1 A/H7 results in serological responses following a delayed boost with 1 dose of unadjuvanted IIV1 A/H7N9, despite lack of antibody response after the prime. Optimizing prime-boost approaches would benefit pandemic preparedness. ClinicalTrials.gov identifier: NCT02586792. PMID: 30955980 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 4, 2019 Category: Allergy & Immunology Authors: El Sahly HM, Atmar RL, Patel SM, Bellamy A, Liu L, Hong W, Zhu H, Guan Y, Keitel WA, DMID 13-0033 Vaccine Study Group Tags: Vaccine Source Type: research
Maternal interventions vigilance harmonization in low- and middle-income countries: Stakeholder meeting report; Amsterdam, May 1-2, 2018.
Abstract Although major reductions in maternal and child mortality were achieved in the Millennium Development Goals era, progress must be accelerated to meet Sustainable Development Goals health targets by 2030. An estimated 2.7 million neonatal deaths and 2.6 million stillbirths still occur annually. Over the past several years there has been renewed global interest in innovative approaches to maternal immunization to potentially decrease mortality and severe morbidity in neonates, and in the pregnant woman and her fetus. Several new vaccines are in clinical development for indications in pregnant women, e.g...
Source: Vaccine - April 4, 2019 Category: Allergy & Immunology Authors: Sobanjo-Ter Meulen A, Munoz FM, Kaslow DC, Klugman KP, Omer SB, Vora P, Stergachis A Tags: Vaccine Source Type: research
Immunogenicity and lot-to-lot consistency of a ready to use liquid bovine-human reassortant pentavalent rotavirus vaccine (ROTASIIL - Liquid) in Indian infants.
CONCLUSION: The immunological non-inferiority of LBRV-PV against Rotasiil® as well as lot-to-lot consistency of LBRV-PV was demonstrated. LBRV-PV had safety profile similar to Rotasiil®. TRIAL REGISTRATION NUMBER: Clinical Trials.Gov [NCT03474055] and Clinical Trial Registry of India [CTRI/2017/10/010104]. PMID: 30955982 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 4, 2019 Category: Allergy & Immunology Authors: Kawade A, Babji S, Kamath V, Raut A, Kumar CM, Kundu R, Venkatramanan P, Lalwani SK, Bavdekar A, Juvekar S, Dayma G, Patil R, Kulkarni M, Hegde A, Nayak D, Garg BS, Gupta S, Jategaonkar S, Bedi N, Maliye C, Ganguly N, Uttam KG, Niyogi P, Palkar S, Hanuman Tags: Vaccine Source Type: research
Seasonal influenza vaccines induced high levels of neutralizing cross-reactive antibody responses against different genetic group influenza A(H1N1)pdm09 viruses.
Abstract Influenza A(H1N1)pdm09 viruses have been circulating throughout the world since the 2009 pandemic. A/California/07/2009 (H1N1) virus was included in seasonal influenza vaccines for seven years altogether, providing a great opportunity to analyse vaccine-induced immunity in relation to the postpandemic evolution of the A(H1N1)pdm09 virus. Serum antibodies against various epidemic strains of influenza A(H1N1)pdm09 viruses were measured among health care workers (HCWs) by haemagglutination inhibition and microneutralization tests before and after 2010 and 2012 seasonal influenza vaccinations. We detected hig...
Source: Vaccine - April 3, 2019 Category: Allergy & Immunology Authors: Haveri A, Ikonen N, Kantele A, Anttila VJ, Ruotsalainen E, Savolainen-Kopra C, Julkunen I Tags: Vaccine Source Type: research
A complementary approach to the vaccination promotion continuum: An immunization-specific motivational-interview training for nurses.
CONCLUSIONS: Our immunization-specific MI-training enabled immunization nurses to significantly improve MI knowledge, skills and self-confidence in applying MI in the clinic. These results, taken together with those on the MI-based intervention for parents that we previously reported, support the notion of proposing validated immunization-specific MI training for immunization nurses in order to curb parental VH. IMPACT: Immunization-specific MI-training would be easily amenable for the training of other health professionals in the field of immunization to help promote vaccination and curb parental VH. PMID: 30954...
Source: Vaccine - April 3, 2019 Category: Allergy & Immunology Authors: Gagneur A, Bergeron J, Gosselin V, Farrands A, Baron G Tags: Vaccine Source Type: research
Intraseason decline in influenza vaccine effectiveness during the 2016 southern hemisphere influenza season: A test-negative design study and phylogenetic assessment.
DISCUSSION: Overall, the 2016 influenza vaccine showed good protection against laboratory-confirmed infection among general practice patients. Results by duration of vaccination suggest a significant decline in effectiveness during the 2016 influenza season, indicating immunization close to influenza season offered optimal protection. PMID: 30952499 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 2, 2019 Category: Allergy & Immunology Authors: Regan AK, Fielding JE, Chilver MB, Carville KS, Minney-Smith CA, Grant KA, Thomson C, Hahesy T, Deng YM, Stocks N, Sullivan SG Tags: Vaccine Source Type: research
Kinetics of maternally-derived serogroup A, C, Y and W-specific meningococcal immunoglobulin G in Malian women and infants.
Abstract A prospective, randomised, controlled observer-blind trial measuring the efficacy and immunogenicity of trivalent influenza vaccine (TIV) and the immunogenicity of quadrivalent meningococcal conjugate vaccine (MCV) in pregnant women and their infants up to 6 months of age was conducted in Mali. Here we reported the immunogenicity of MCV, which was used as a comparator vaccine to TIV, in this population. Third-trimester pregnant Malian women were randomized to receive TIV or MCV. Blood samples were collected from women prior to vaccination, 28 days post-vaccination, at delivery and 3 and 6 months pos...
Source: Vaccine - April 2, 2019 Category: Allergy & Immunology Authors: Findlow H, Tapia MD, Sow SO, Haidara FC, Coulibaly F, Keita AM, Diallo F, Doumbia M, Traore A, Schluterman N, Clark DA, Borrow R, Levine MM Tags: Vaccine Source Type: research
The natural course of a localized BCG vaccine abscess.
PMID: 30952502 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - April 2, 2019 Category: Allergy & Immunology Authors: Brummaier T, Poe Yen Yen S, Keereecharoen D, McGready R, Vincenti-Delmas M Tags: Vaccine Source Type: research
The effectiveness of maternal pertussis vaccination in protecting newborn infants in Brazil: A case-control study.
Abstract INTRODUCTION: In 2014, the Brazilian Ministry of Health (MoH) recommended Tdap to pregnant women in response to a significant increase in the incidence of pertussis among infants. The present study assessed the effectiveness of maternal immunization in preventing pertussis in infants. METHODS: An unmatched case-control study was undertaken in São Paulo State, Brazil from February 2015 to July 2016. Cases were infants aged
Source: Vaccine - April 1, 2019 Category: Allergy & Immunology Authors: Fernandes EG, Sato APS, Vaz-de-Lima LRA, Rodrigues M, Leite D, de Brito CA, Luna EJA, Carvalhanas TRMP, Ramos MLBN, Sato HK, de Castilho EA, Maternal Pertussis Vaccine Working Group Tags: Vaccine Source Type: research
Assessing vaccine hesitancy in the UK population using a generalized vaccine hesitancy survey instrument.
CONCLUSION: Our study suggests that whereas a substantial percentage of the British population is vaccine hesitant, these views are not clustered in typical demographic features. The small but important adaptation of the VHS to target general attitudes seems to result in highly similar psychometric characteristics as the original scale that exclusively targets parents. We provide suggestions for further validation of the VHS. PMID: 30940484 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 30, 2019 Category: Allergy & Immunology Authors: Luyten J, Bruyneel L, van Hoek AJ Tags: Vaccine Source Type: research
Oral and systemic HPV antibody kinetics post-vaccination among HIV-positive and HIV-negative men.
Abstract Duration and functional aspects of the oral and systemic antibody responses following HPV vaccination in HIV-negative (HIV-) and HIV-positive (HIV+) men are not well characterized. Oral and systemic HPV-16 and HPV-18-specific antibody levels were evaluated over 18-months of follow-up, in HIV+ and HIV- men. Sera and oral gargles from 147 HIV- men, ages 27-45 and 75 HIV+ men, ages 22-61, who received 3-doses of quadrivalent HPV vaccine were tested for HPV-16 and HPV-18 antibodies at Day 1, Month 7 (1 month post-dose 3), and Month 18 (12 months post-dose 3) and HPV avidity (Day 1, and Month 7) using L1-V...
Source: Vaccine - March 30, 2019 Category: Allergy & Immunology Authors: Pinto LA, Wilkin TJ, Kemp TJ, Abrahamsen M, Isaacs-Soriano K, Pan Y, Webster-Cyriaque J, Palefsky JM, Giuliano AR Tags: Vaccine Source Type: research
Seasonal gaps in measles vaccination coverage in Madagascar.
DISCUSSION: Evidence that routine vaccination coverage varies over the year and is diminished by other activities suggests that maintaining routine vaccination during SIAs and VWs is a key direction for strengthening immunization programs, ensuring population immunity and avoiding future outbreaks. FUNDING: Wellcome Trust Fund, Burroughs Wellcome Fund, Gates Foundation, National Institutes of Health. PMID: 30940486 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 30, 2019 Category: Allergy & Immunology Authors: Mensah K, Heraud JM, Takahashi S, Winter AK, Metcalf CJE, Wesolowski A Tags: Vaccine Source Type: research
Hepatitis B virus-specific effector CD8+ T cells are an important determinant of disease prognosis: A meta-analysis.
CONCLUSION: HBV-specific effector CD8+ T cells influence the disease activity in HBV-infected patients in various ways and determine prognosis by eliminating the virus. Therefore, efforts of studying HBV-specific effector CD8+ T cells focused vaccine are potentially needed. PMID: 30935741 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 29, 2019 Category: Allergy & Immunology Authors: Zheng J, Ou Z, Xu Y, Xia Z, Lin X, Jin S, Liu Y, Wu J Tags: Vaccine Source Type: research
Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials.
CONCLUSIONS: No safety concerns arose, supporting the favorable benefit-risk profile of RZV. PMID: 30935742 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 29, 2019 Category: Allergy & Immunology Authors: López-Fauqued M, Campora L, Delannois F, El Idrissi M, Oostvogels L, De Looze FJ, Diez-Domingo J, Heineman TC, Lal H, McElhaney JE, McNeil SA, Yeo W, Tavares-Da-Silva F, ZOE-50/70 Study Group Tags: Vaccine Source Type: research
Modification of the vaccine manufacturing process improves the pyrogenicity profile of inactivated influenza vaccines in young children.
Abstract BACKGROUND: There were increased reports of fevers and febrile reactions in young children (particularly children aged
Source: Vaccine - March 29, 2019 Category: Allergy & Immunology Authors: Sawlwin DC, Graves Jones A, Albano FR Tags: Vaccine Source Type: research
Design of a mimotope-peptide based double epitope vaccine against disseminated candidiasis.
Abstract Hematogenously disseminated candidiasis in humans is the third leading cause of nosocomial bloodstream infections in the US. There is no FDA approved antifungal vaccine or prophylactic/therapeutic antibody for use in humans. We first reported novel synthetic peptide and glycopeptide vaccines against Candida albicans cell surface epitopes that protect mice against disseminated candidiasis. We showed that antibodies specific for the peptide Fba (derived from C. albicans cell surface protein fructose bisphosphate aldolase) or for C. albicans cell surface glycan epitope β-1, 2-mannotriose [β-(Man)3]...
Source: Vaccine - March 28, 2019 Category: Allergy & Immunology Authors: Xin H, Glee P, Adams A, Mohiuddin F, Eberle K Tags: Vaccine Source Type: research
Participant centred safety surveillance of health care workers receiving influenza vaccination.
Abstract Following the introduction of mandatory influenza vaccination for staff working in high risk clinical areas in 2018, we conducted active surveillance for adverse events following immunisation utilising an automated online survey to vaccine recipients at three and 42 days post immunisation. Most participants 2285 (92%) agreed to participate; 515 (32%) staff reported any symptom and eight (1.6%) sought medical attention. The odds of having a reaction decreased with age by approximately 2% per year. The system was acceptable to staff, and the data demonstrated rates of reported symptoms within expected rat...
Source: Vaccine - March 28, 2019 Category: Allergy & Immunology Authors: Cashman P, Moberley S, Chee K, Stephenson J, Chaverot S, Martinelli J, Gadsden T, Bateman-Steel C, Redwood L, Howard Z, Ferson MJ, Durrheim DN Tags: Vaccine Source Type: research
Sociodemographic, clinical and birth hospitalization characteristics and infant Hepatitis B vaccination in Washington State.
This study aimed to identify the sociodemographic, clinical and birth hospitalization factors associated with timely receipt of the first HepB vaccine dose. STUDY DESIGN: This retrospective cohort study included Washington State infants born weighing ≥2000 g who received birth hospitalization care at an urban academic medical center between January 2008-December 2013. Multivariable logistic regression was used to estimate adjusted odds ratios (AOR) and 95% confidence intervals (CI) for associations between maternal and infant characteristics and HepB vaccine receipt during the birth hospitalization. RESULTS:...
Source: Vaccine - March 28, 2019 Category: Allergy & Immunology Authors: Oster NV, Williams EC, Unger JM, Newcomb PA, Jacobson EN, deHart MP, Englund JA, Hofstetter AM Tags: Vaccine Source Type: research
Age-related differences in antibody avidities to pertussis toxin and filamentous hemagglutinin in a healthy Japanese population.
Abstract To gain insights into the current Japanese pertussis immunization schedule, we examined the distributions of antibody titers and avidities to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in 460 Japanese healthy subjects (aged 1-60 years) based on age category. Our avidity enzyme-linked immunosorbent assays revealed that young children aged 1-2 years, which corresponded to ages after receiving primary and/or booster pertussis vaccinations, had relatively high-avidity anti-PT IgG (mean avidity index [AI], 40.5%) compared with other age groups (AI, 26.5-31.9%); however, they had relatively lo...
Source: Vaccine - March 28, 2019 Category: Allergy & Immunology Authors: Fumimoto R, Otsuka N, Sunagawa T, Tanaka-Taya K, Kamiya H, Kamachi K Tags: Vaccine Source Type: research
Racial disparities in U.S. maternal influenza vaccine uptake: Results from analysis of Pregnancy Risk Assessment Monitoring System (PRAMS) data, 2012-2015.
CONCLUSIONS: Our findings indicate that there are racial/ethnic disparities in healthcare provider recommendation and influenza vaccine uptake among pregnant women in the United States. Targeted efforts toward providers and interventions focusing on pregnant women may be warranted to reduce the disparity. PMID: 30928172 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 27, 2019 Category: Allergy & Immunology Authors: Arnold LD, Luong L, Rebmann T, Chang JJ Tags: Vaccine Source Type: research