Development of a bivalent conjugate vaccine candidate against rotaviral diarrhea and tuberculosis using polysaccharide from Mycobacterium tuberculosis conjugated to ΔVP8* protein from rotavirus
Vaccine. 2021 Oct 9:S0264-410X(21)01282-2. doi: 10.1016/j.vaccine.2021.09.067. Online ahead of print.ABSTRACTConjugation of carbohydrate antigens with a carrier protein is a clinically proven strategy to overcome the poor immunogenicity of bacterial polysaccharide. In addition to its primary role, which is to help generate a T cell-mediate long-lasting immune response directed against the carbohydrate antigen, the carrier protein in a glycoconjugate vaccine can also play an important role as a protective antigen. Among carrier proteins currently used in licensed conjugate vaccines, non-typeable Haemophilus influenzae prote...
Source: Vaccine - October 13, 2021 Category: Allergy & Immunology Authors: Wook-Jin Park Yeon-Kyung Yoon Youngmi Kim Ji-Sun Park Ruchirkumar Pansuriya Sang-Nae Cho Yeong-Jae Seok Ganapathy Ravi Source Type: research

Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452
Vaccine. 2021 Oct 5:S0264-410X(21)01294-9. doi: 10.1016/j.vaccine.2021.09.077. Online ahead of print.ABSTRACTAKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic. The Fc moiety is designed to enhance immunogenicity by increasing uptake via Fc-receptors (FcγR) on Ag-presenting cells (APCs) and prolonging exposure due to neonatal Fc receptor...
Source: Vaccine - October 13, 2021 Category: Allergy & Immunology Authors: David G Alleva Andrea R Delpero Melanie M Scully Sylaja Murikipudi Ramya Ragupathy Emma K Greaves Thillainaygam Sathiyaseelan Jeffrey R Haworth Nishit J Shah Vidhya Rao Shashikant Nagre Thomas M Lancaster Sarah S Webb Allison I Jasa Shannon E Ronca Freedo Source Type: research

Development of a bivalent conjugate vaccine candidate against rotaviral diarrhea and tuberculosis using polysaccharide from Mycobacterium tuberculosis conjugated to ΔVP8* protein from rotavirus
Vaccine. 2021 Oct 9:S0264-410X(21)01282-2. doi: 10.1016/j.vaccine.2021.09.067. Online ahead of print.ABSTRACTConjugation of carbohydrate antigens with a carrier protein is a clinically proven strategy to overcome the poor immunogenicity of bacterial polysaccharide. In addition to its primary role, which is to help generate a T cell-mediate long-lasting immune response directed against the carbohydrate antigen, the carrier protein in a glycoconjugate vaccine can also play an important role as a protective antigen. Among carrier proteins currently used in licensed conjugate vaccines, non-typeable Haemophilus influenzae prote...
Source: Vaccine - October 13, 2021 Category: Allergy & Immunology Authors: Wook-Jin Park Yeon-Kyung Yoon Youngmi Kim Ji-Sun Park Ruchirkumar Pansuriya Sang-Nae Cho Yeong-Jae Seok Ganapathy Ravi Source Type: research

Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452
Vaccine. 2021 Oct 5:S0264-410X(21)01294-9. doi: 10.1016/j.vaccine.2021.09.077. Online ahead of print.ABSTRACTAKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic. The Fc moiety is designed to enhance immunogenicity by increasing uptake via Fc-receptors (FcγR) on Ag-presenting cells (APCs) and prolonging exposure due to neonatal Fc receptor...
Source: Vaccine - October 13, 2021 Category: Allergy & Immunology Authors: David G Alleva Andrea R Delpero Melanie M Scully Sylaja Murikipudi Ramya Ragupathy Emma K Greaves Thillainaygam Sathiyaseelan Jeffrey R Haworth Nishit J Shah Vidhya Rao Shashikant Nagre Thomas M Lancaster Sarah S Webb Allison I Jasa Shannon E Ronca Freedo Source Type: research

A new fully liquid presentation of MenACWY-CRM conjugate vaccine: Results from a multicentre, randomised, controlled, observer-blind study
CONCLUSIONS: The levels of MenA free saccharide and polysaccharide O-acetylation did not affect the immunogenicity of the fully liquid presentation, which was demonstrated to be non-inferior to the immunogenicity of the currently licensed MenACWY-CRM vaccine against MenA. The immunogenicity, reactogenicity and safety profiles of the two vaccine presentations were similar.PMID:34635373 | DOI:10.1016/j.vaccine.2021.09.068 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: Corinne Vandermeulen Isabel Leroux-Roels James Vandeleur Tommaso Staniscia Ginette Girard Murdo Ferguson Giancarlo Icardi Tino F Schwarz A Munro Neville Terry Nolan Sandro Cinquetti Tauseefullah Akhund Sofie Van Huyneghem Marianna Aggravi Barry Kunnel Ber Source Type: research

Effect of contamination and purity priming on attitudes to vaccination and other health interventions: A randomised controlled experiment
In conclusion, this online experiment did not find an experimental effect of priming for contamination and purity on subjects' ratings of the safety and effectiveness of conventional and alternative health interventions. This indicates that attitudes to these health interventions are not influenced by a temporary increase in the salience of feelings of contamination or purity. However, individual differences in disgust sensitivity are related to their attitudes to vaccination and CAM interventions.PMID:34635374 | DOI:10.1016/j.vaccine.2021.09.063 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: Gabrielle M Bryden Matthew Rockloff Matthew Browne Carolyn Unsworth Source Type: research

Impact analysis of rotavirus vaccination in various geographic regions in Western Europe
CONCLUSIONS: The introduction of rotavirus UMV resulted in an overall reduction of 42% in rotavirus incidence in Western European countries two years after vaccine introduction and caused a change in seasonal pattern. No herd effect induced by UMV neighbouring countries was observed for Denmark and the Netherlands.PMID:34635375 | DOI:10.1016/j.vaccine.2021.09.059 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: J D M Verberk J A P van Dongen J van de Kassteele N J Andrews R D van Gaalen S J M Hahn é H Vennema M Ramsay T Braeckman S Ladhani S L Thomas J L Walker H E de Melker T K Fischer J Koch P Bruijning-Verhagen Source Type: research

A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States
We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273 (1/9).METHODS: All patients were referred for AP temporally linked with COVID-19 vaccination. Chest pain was the most common clinical manifestation. Alternative etiologies were excluded upon thorough diagnostic work up. AP diagnosis was established according to ESC guidelines.FINDINGS: Five events occurred after the first vaccine dose and four after the second. The mean age in this cohort was 65.8 ± 10.2 years and the men/women ratio 3/5. All events resolved without seque...
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: George Lazaros Cleo Anastassopoulou Sophia Hatziantoniou Theodoros Kalos Stergios Soulaidopoulos Emilia Lazarou Charalambos Vlachopoulos Dimitrios Vassilopoulos Athanasios Tsakris Costas Tsioufis Source Type: research

The influenza vaccines roadmap - A better future through improved influenza vaccines
Vaccine. 2021 Oct 8:S0264-410X(21)01286-X. doi: 10.1016/j.vaccine.2021.09.071. Online ahead of print.NO ABSTRACTPMID:34635377 | PMC:PMC8499092 | DOI:10.1016/j.vaccine.2021.09.071 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: Peter Hart Jeremy Farrar Source Type: research

A new fully liquid presentation of MenACWY-CRM conjugate vaccine: Results from a multicentre, randomised, controlled, observer-blind study
CONCLUSIONS: The levels of MenA free saccharide and polysaccharide O-acetylation did not affect the immunogenicity of the fully liquid presentation, which was demonstrated to be non-inferior to the immunogenicity of the currently licensed MenACWY-CRM vaccine against MenA. The immunogenicity, reactogenicity and safety profiles of the two vaccine presentations were similar.PMID:34635373 | DOI:10.1016/j.vaccine.2021.09.068 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: Corinne Vandermeulen Isabel Leroux-Roels James Vandeleur Tommaso Staniscia Ginette Girard Murdo Ferguson Giancarlo Icardi Tino F Schwarz A Munro Neville Terry Nolan Sandro Cinquetti Tauseefullah Akhund Sofie Van Huyneghem Marianna Aggravi Barry Kunnel Ber Source Type: research

Effect of contamination and purity priming on attitudes to vaccination and other health interventions: A randomised controlled experiment
In conclusion, this online experiment did not find an experimental effect of priming for contamination and purity on subjects' ratings of the safety and effectiveness of conventional and alternative health interventions. This indicates that attitudes to these health interventions are not influenced by a temporary increase in the salience of feelings of contamination or purity. However, individual differences in disgust sensitivity are related to their attitudes to vaccination and CAM interventions.PMID:34635374 | DOI:10.1016/j.vaccine.2021.09.063 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: Gabrielle M Bryden Matthew Rockloff Matthew Browne Carolyn Unsworth Source Type: research

Impact analysis of rotavirus vaccination in various geographic regions in Western Europe
CONCLUSIONS: The introduction of rotavirus UMV resulted in an overall reduction of 42% in rotavirus incidence in Western European countries two years after vaccine introduction and caused a change in seasonal pattern. No herd effect induced by UMV neighbouring countries was observed for Denmark and the Netherlands.PMID:34635375 | DOI:10.1016/j.vaccine.2021.09.059 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: J D M Verberk J A P van Dongen J van de Kassteele N J Andrews R D van Gaalen S J M Hahn é H Vennema M Ramsay T Braeckman S Ladhani S L Thomas J L Walker H E de Melker T K Fischer J Koch P Bruijning-Verhagen Source Type: research

A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States
We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273 (1/9).METHODS: All patients were referred for AP temporally linked with COVID-19 vaccination. Chest pain was the most common clinical manifestation. Alternative etiologies were excluded upon thorough diagnostic work up. AP diagnosis was established according to ESC guidelines.FINDINGS: Five events occurred after the first vaccine dose and four after the second. The mean age in this cohort was 65.8 ± 10.2 years and the men/women ratio 3/5. All events resolved without seque...
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: George Lazaros Cleo Anastassopoulou Sophia Hatziantoniou Theodoros Kalos Stergios Soulaidopoulos Emilia Lazarou Charalambos Vlachopoulos Dimitrios Vassilopoulos Athanasios Tsakris Costas Tsioufis Source Type: research

The influenza vaccines roadmap - A better future through improved influenza vaccines
Vaccine. 2021 Oct 8:S0264-410X(21)01286-X. doi: 10.1016/j.vaccine.2021.09.071. Online ahead of print.NO ABSTRACTPMID:34635377 | DOI:10.1016/j.vaccine.2021.09.071 (Source: Vaccine)
Source: Vaccine - October 12, 2021 Category: Allergy & Immunology Authors: Peter Hart Jeremy Farrar Source Type: research

Christian nationalism and COVID-19 vaccine hesitancy and uptake
Vaccine. 2021 Oct 2:S0264-410X(21)01289-5. doi: 10.1016/j.vaccine.2021.09.074. Online ahead of print.ABSTRACTUnderstanding COVID-19 vaccine hesitancy and uptake is vital for informing public health interventions. Prior U.S. research has found that religious conservatism is positively associated with anti-vaccine attitudes. One of the strongest predictors of anti-vaccine attitudes in the U.S. is Christian nationalism-a U.S. cultural ideology that wants civic life to be permeated by their particular form of nationalist Christianity. However, there are no studies examining the relationship between Christian nationalism and CO...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Katie E Corcoran Christopher P Scheitle Bernard D DiGregorio Source Type: research

Modelling the spread of serotype-2 vaccine derived-poliovirus outbreak in Pakistan and Afghanistan to inform outbreak control strategies in the context of the COVID-19 pandemic
CONCLUSION: Outbreak response vaccination campaigns against cVDPV2 will be challenging throughout the COVID-19 pandemic but must be implemented urgently when feasible to stop transmission of cVDPV2.PMID:34629206 | DOI:10.1016/j.vaccine.2021.09.037 (Source: Vaccine)
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Natalia A Molodecky Hamid Jafari Rana M Safdar Jamal A Ahmed Abdirahman Mahamud Ananda S Bandyopadhyay Hemant Shukla Arshad Quddus Michel Zaffran Roland W Sutter Nicholas C Grassly Isobel M Blake Source Type: research

Strengthening the immunization supply chain: A time-to-supply based approach to cold chain network optimization & amp; extension in Madhya Pradesh
Vaccine. 2021 Oct 8:S0264-410X(21)01277-9. doi: 10.1016/j.vaccine.2021.09.062. Online ahead of print.ABSTRACTExpansion of immunization coverage is dependent in part on delivering potent vaccines in an equitable and timely manner to immunization outreach session sites from Cold Chain Points (CCPs). When duration of travel between the last CCP and the session site (Time-to-Supply) is too long, three consequences may arise: decreased potency due to exposure to heat and freezing, beneficiary dropouts due to delayed session starts, and, increased operational costs for the Health Facility (HF) conducting the outreach sessions. G...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Varun Srivastava Manish Ratna Arindam Ray Santosh Shukla Vipin Shrivastava Nitin Kothari Amandeep Gupta Meenal Kukreja Harkabir Singh Jandu Source Type: research

Supporting National Immunization Technical Advisory Groups in the WHO European Region in developing national COVID-19 vaccination recommendations through online communication platform
Vaccine. 2021 Sep 16:S0264-410X(21)01225-1. doi: 10.1016/j.vaccine.2021.09.034. Online ahead of print.ABSTRACTNational Immunization Technical Advisory Groups are groups of multi-disciplinary experts that provide scientific advice to policy makers to enable them to make informed immunization policy and programme decisions. NITAGs faced challengesusing their routine approach to develop recommendations for COVID-19 vaccines during the pandemic. In response, the WHORegional Office for Europe (Regional Office), with the support of theRobert Koch Institute, developedan innovative approach of a series of webinars, provision of ma...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Liudmila Mosina Wiebe K ülper-Schiek Lisa Jacques-Carroll Andrew Earnshaw Thomas Harder Federico Martin ón-Torres Annelies Wilder-Smith Ole Wichmann Siddhartha Sankar Datta Source Type: research

Vaccination coverage among young homeless children compared to US national immunization survey data
This study compared vaccination coverage with a combined 7-vaccines series among homeless children in the District of Columbia (DC) to coverage among other US children.MATERIALS AND METHODS: A cross-sectional survey of homeless children in DC was conducted from 2018 to 2019. Recruitment occurred at housing shelters, social services centers, and a diaper dispensary, and through limited chain referral. English-speaking parents of a child aged 19 to 35 months who spent the majority of the last 30 nights homeless were recruited. Participants consented for their child's healthcare providers to submit vaccination records. The va...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Linda Y Fu Rachel Torres Susan Caleb Yao I Cheng Erica Gennaro Elizabeth Thoburn John McLaughlin Ronika Alexander-Parrish Jichuan Wang Source Type: research

Preferences for COVID-19 vaccination information and location: Associations with vaccine hesitancy, race and ethnicity
This study examined the association between preferences for being informed about the COVID-19 vaccine and where to receive it with vaccination intent and race/ethnicity. We conducted an online survey, oversampling Black and Latino panel members. The 1668 participants were 53.2% female, 34.8% White, 33.3% Black, and 31.8% Latino. Participants who were vaccine hesitant (answered "not sure" or "no" to vaccination intent) were more likely to prefer a conversation with their doctor compared to those who answered "yes" (25.0% and 23.4% vs 7.8%, P
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Kimberly A Fisher Ngoc Nguyen Sybil Crawford Hassan Fouayzi Sonal Singh Kathleen M Mazor Source Type: research

Christian nationalism and COVID-19 vaccine hesitancy and uptake
Vaccine. 2021 Oct 2:S0264-410X(21)01289-5. doi: 10.1016/j.vaccine.2021.09.074. Online ahead of print.ABSTRACTUnderstanding COVID-19 vaccine hesitancy and uptake is vital for informing public health interventions. Prior U.S. research has found that religious conservatism is positively associated with anti-vaccine attitudes. One of the strongest predictors of anti-vaccine attitudes in the U.S. is Christian nationalism-a U.S. cultural ideology that wants civic life to be permeated by their particular form of nationalist Christianity. However, there are no studies examining the relationship between Christian nationalism and CO...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Katie E Corcoran Christopher P Scheitle Bernard D DiGregorio Source Type: research

Modelling the spread of serotype-2 vaccine derived-poliovirus outbreak in Pakistan and Afghanistan to inform outbreak control strategies in the context of the COVID-19 pandemic
CONCLUSION: Outbreak response vaccination campaigns against cVDPV2 will be challenging throughout the COVID-19 pandemic but must be implemented urgently when feasible to stop transmission of cVDPV2.PMID:34629206 | DOI:10.1016/j.vaccine.2021.09.037 (Source: Vaccine)
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Natalia A Molodecky Hamid Jafari Rana M Safdar Jamal A Ahmed Abdirahman Mahamud Ananda S Bandyopadhyay Hemant Shukla Arshad Quddus Michel Zaffran Roland W Sutter Nicholas C Grassly Isobel M Blake Source Type: research

Strengthening the immunization supply chain: A time-to-supply based approach to cold chain network optimization & amp; extension in Madhya Pradesh
Vaccine. 2021 Oct 8:S0264-410X(21)01277-9. doi: 10.1016/j.vaccine.2021.09.062. Online ahead of print.ABSTRACTExpansion of immunization coverage is dependent in part on delivering potent vaccines in an equitable and timely manner to immunization outreach session sites from Cold Chain Points (CCPs). When duration of travel between the last CCP and the session site (Time-to-Supply) is too long, three consequences may arise: decreased potency due to exposure to heat and freezing, beneficiary dropouts due to delayed session starts, and, increased operational costs for the Health Facility (HF) conducting the outreach sessions. G...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Varun Srivastava Manish Ratna Arindam Ray Santosh Shukla Vipin Shrivastava Nitin Kothari Amandeep Gupta Meenal Kukreja Harkabir Singh Jandu Source Type: research

Supporting National Immunization Technical Advisory Groups in the WHO European Region in developing national COVID-19 vaccination recommendations through online communication platform
Vaccine. 2021 Sep 16:S0264-410X(21)01225-1. doi: 10.1016/j.vaccine.2021.09.034. Online ahead of print.ABSTRACTNational Immunization Technical Advisory Groups are groups of multi-disciplinary experts that provide scientific advice to policy makers to enable them to make informed immunization policy and programme decisions. NITAGs faced challengesusing their routine approach to develop recommendations for COVID-19 vaccines during the pandemic. In response, the WHORegional Office for Europe (Regional Office), with the support of theRobert Koch Institute, developedan innovative approach of a series of webinars, provision of ma...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Liudmila Mosina Wiebe K ülper-Schiek Lisa Jacques-Carroll Andrew Earnshaw Thomas Harder Federico Martin ón-Torres Annelies Wilder-Smith Ole Wichmann Siddhartha Sankar Datta Source Type: research

Vaccination coverage among young homeless children compared to US national immunization survey data
This study compared vaccination coverage with a combined 7-vaccines series among homeless children in the District of Columbia (DC) to coverage among other US children.MATERIALS AND METHODS: A cross-sectional survey of homeless children in DC was conducted from 2018 to 2019. Recruitment occurred at housing shelters, social services centers, and a diaper dispensary, and through limited chain referral. English-speaking parents of a child aged 19 to 35 months who spent the majority of the last 30 nights homeless were recruited. Participants consented for their child's healthcare providers to submit vaccination records. The va...
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Linda Y Fu Rachel Torres Susan Caleb Yao I Cheng Erica Gennaro Elizabeth Thoburn John McLaughlin Ronika Alexander-Parrish Jichuan Wang Source Type: research

Preferences for COVID-19 vaccination information and location: Associations with vaccine hesitancy, race and ethnicity
This study examined the association between preferences for being informed about the COVID-19 vaccine and where to receive it with vaccination intent and race/ethnicity. We conducted an online survey, oversampling Black and Latino panel members. The 1668 participants were 53.2% female, 34.8% White, 33.3% Black, and 31.8% Latino. Participants who were vaccine hesitant (answered "not sure" or "no" to vaccination intent) were more likely to prefer a conversation with their doctor compared to those who answered "yes" (25.0% and 23.4% vs 7.8%, P
Source: Vaccine - October 11, 2021 Category: Allergy & Immunology Authors: Kimberly A Fisher Ngoc Nguyen Sybil Crawford Hassan Fouayzi Sonal Singh Kathleen M Mazor Source Type: research

Strategies for vaccine-product innovation: Creating an enabling environment for product development to uptake in low- and middle-income countries
Vaccine. 2021 Oct 6:S0264-410X(21)00996-8. doi: 10.1016/j.vaccine.2021.07.091. Online ahead of print.ABSTRACTVaccine-product innovations that address barriers to immunization are urgently needed to achieve equitable vaccine coverage, as articulated in the new Immunization Agenda 2030 and the Gavi 5.0 strategy. In 2020, the Vaccine Innovation Prioritisation Strategy (VIPS) prioritized three innovations, namely microarray patches (MAPs), heat-stable and controlled-temperature chain (CTC) enabled liquid vaccine formulations and barcodes on primary packaging. These innovations were prioritized based on the priority immunizatio...
Source: Vaccine - October 10, 2021 Category: Allergy & Immunology Authors: Birgitte Giersing Natasha Shah Debra Kristensen Jean-Pierre Amorij Anna-Lea Kahn Kristoffer Gandrup-Marino Courtney Jarrahian Darin Zehrung Marion Menozzi-Arnaud Source Type: research

Impact of the childhood influenza vaccine programme on antibiotic prescribing rates in primary care in England
Vaccine. 2021 Oct 6:S0264-410X(21)01284-6. doi: 10.1016/j.vaccine.2021.09.069. Online ahead of print.ABSTRACTVaccines are a key part of the global strategy to tackle antimicrobial resistance (AMR) since prevention of infection should reduce antibiotic use. England commenced national rollout of a live attenuated influenza vaccine (LAIV) programme for children aged 2-3 years together with a series of geographically discrete pilot areas for primary school age children in 2013 extending to older children in subsequent seasons. We investigated vaccine programme impact on community antibiotic prescribing rates. Antibiotic prescr...
Source: Vaccine - October 10, 2021 Category: Allergy & Immunology Authors: Berit Muller-Pebody Mary A Sinnathamby Fiona Warburton Graeme Rooney Nick Andrews Heather Whitaker Katherine L Henderson Camille Tsang Susan Hopkins Richard G Pebody Source Type: research

Effects of Mycobacterium bovis Calmette et Gu érin (BCG) in oncotherapy: Bladder cancer and beyond
Vaccine. 2021 Oct 6:S0264-410X(21)01256-1. doi: 10.1016/j.vaccine.2021.09.053. Online ahead of print.ABSTRACTThe Mycobacterium bovis Bacillus Calmette et Guérin (BCG) vaccine was generated in 1921 with the efforts of a team of investigators, Albert Calmette and Camille Guérin, dedicated to the determination to develop a vaccine against active tuberculosis (TB) disease. Since then, BCG vaccination is used globally for protection against childhood and disseminated TB; however, its efficacy at protecting against pulmonary TB in adult and aging populations is highly variable. Due to the BCG generated immunity, th...
Source: Vaccine - October 10, 2021 Category: Allergy & Immunology Authors: Neelam Mukherjee Esther Juli án Jordi B Torrelles Robert S Svatek Source Type: research

Persisting antibody responses to Vi polysaccharide-tetanus toxoid conjugate (Typbar TCV ®) vaccine up to 7 years following primary vaccination of children  & lt;  2 years of age with, or without, a booster vaccination
CONCLUSION: To extend protection, administering a booster of Typbar TCV® to children ∼5 years after their primary dose, i.e., coinciding with school entry, may be advisable. Typbar TCV® is presently the only WHO pre-qualified Vi conjugate vaccine with reported efficacy, effectiveness, and long-term immunogenicity findings.PMID:34625288 | DOI:10.1016/j.vaccine.2021.07.073 (Source: Vaccine)
Source: Vaccine - October 9, 2021 Category: Allergy & Immunology Authors: Krishna Mohan Vadrevu Dugyala Raju Sandhya Rani Siddharth Reddy Vamshi Sarangi Raches Ella Bhuvaneswara Javvaji Niranjana S Mahantshetty Sudhakar Battu Myron M Levine Source Type: research

All vials are not the same: Potential role of vaccine quality in vaccine adverse reactions
Vaccine. 2021 Oct 5:S0264-410X(21)01280-9. doi: 10.1016/j.vaccine.2021.09.065. Online ahead of print.NO ABSTRACTPMID:34625289 | PMC:PMC8492451 | DOI:10.1016/j.vaccine.2021.09.065 (Source: Vaccine)
Source: Vaccine - October 9, 2021 Category: Allergy & Immunology Authors: Yihua Bruce Yu Marc B Taraban Katharine T Briggs Source Type: research

Shingles vaccination uptake in Massachusetts adults aged 50 years and older
CONCLUSIONS: More than half of the sub-sample reported not knowing about shingles vaccine, therefore, opportunities to increase awareness should be prioritized. Since provider recommendation and flu vaccination receipt had the greatest odds of increasing shingles vaccination, standard practice should include adding shingles to flu vaccine recommendations for age-eligible patients.PMID:34625290 | DOI:10.1016/j.vaccine.2021.09.032 (Source: Vaccine)
Source: Vaccine - October 9, 2021 Category: Allergy & Immunology Authors: Marina Draper Stella Stergiopoulos Source Type: research

Persisting antibody responses to Vi polysaccharide-tetanus toxoid conjugate (Typbar TCV ®) vaccine up to 7 years following primary vaccination of children  & lt;  2 years of age with, or without, a booster vaccination
CONCLUSION: To extend protection, administering a booster of Typbar TCV® to children ∼5 years after their primary dose, i.e., coinciding with school entry, may be advisable. Typbar TCV® is presently the only WHO pre-qualified Vi conjugate vaccine with reported efficacy, effectiveness, and long-term immunogenicity findings.PMID:34625288 | DOI:10.1016/j.vaccine.2021.07.073 (Source: Vaccine)
Source: Vaccine - October 9, 2021 Category: Allergy & Immunology Authors: Krishna Mohan Vadrevu Dugyala Raju Sandhya Rani Siddharth Reddy Vamshi Sarangi Raches Ella Bhuvaneswara Javvaji Niranjana S Mahantshetty Sudhakar Battu Myron M Levine Source Type: research

All vials are not the same: Potential role of vaccine quality in vaccine adverse reactions
Vaccine. 2021 Oct 5:S0264-410X(21)01280-9. doi: 10.1016/j.vaccine.2021.09.065. Online ahead of print.NO ABSTRACTPMID:34625289 | DOI:10.1016/j.vaccine.2021.09.065 (Source: Vaccine)
Source: Vaccine - October 9, 2021 Category: Allergy & Immunology Authors: Yihua Bruce Yu Marc B Taraban Katharine T Briggs Source Type: research

Shingles vaccination uptake in Massachusetts adults aged 50 years and older
CONCLUSIONS: More than half of the sub-sample reported not knowing about shingles vaccine, therefore, opportunities to increase awareness should be prioritized. Since provider recommendation and flu vaccination receipt had the greatest odds of increasing shingles vaccination, standard practice should include adding shingles to flu vaccine recommendations for age-eligible patients.PMID:34625290 | DOI:10.1016/j.vaccine.2021.09.032 (Source: Vaccine)
Source: Vaccine - October 9, 2021 Category: Allergy & Immunology Authors: Marina Draper Stella Stergiopoulos Source Type: research

A phase III, observer-blind, randomized, placebo-controlled study of the efficacy, safety, and immunogenicity of SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59  years: An interim analysis in Indonesia
CONCLUSIONS: From the 3-month interim analysis, the vaccine exhibited a 65.30% efficacy at preventing COVID-19 illness with favorable safety and immunogenicity profiles.PMID:34620531 | DOI:10.1016/j.vaccine.2021.09.052 (Source: Vaccine)
Source: Vaccine - October 8, 2021 Category: Allergy & Immunology Authors: Eddy Fadlyana Kusnandi Rusmil Rodman Tarigan Andri Reza Rahmadi Susantina Prodjosoewojo Yulia Sofiatin Citra V Khrisna Rini Mulia Sari Lilis Setyaningsih Fikrianti Surachman Novilia Sjafri Bachtiar Hadyana Sukandar Imam Megantara Chrysanti Murad Krisna Nu Source Type: research

A phase III, observer-blind, randomized, placebo-controlled study of the efficacy, safety, and immunogenicity of SARS-CoV-2 inactivated vaccine in healthy adults aged 18-59  years: An interim analysis in Indonesia
CONCLUSIONS: From the 3-month interim analysis, the vaccine exhibited a 65.30% efficacy at preventing COVID-19 illness with favorable safety and immunogenicity profiles.PMID:34620531 | DOI:10.1016/j.vaccine.2021.09.052 (Source: Vaccine)
Source: Vaccine - October 8, 2021 Category: Allergy & Immunology Authors: Eddy Fadlyana Kusnandi Rusmil Rodman Tarigan Andri Reza Rahmadi Susantina Prodjosoewojo Yulia Sofiatin Citra V Khrisna Rini Mulia Sari Lilis Setyaningsih Fikrianti Surachman Novilia Sjafri Bachtiar Hadyana Sukandar Imam Megantara Chrysanti Murad Krisna Nu Source Type: research

Vaccine serocoverage under the expanded program on immunization among hill tribe children in Thailand: A cross-sectional study
This study aimed to assess serocoverage under the EPI and access to vaccination clinics.METHODS: A cross-sectional study was performed to assess serocoverage after childhood vaccination among hill tribe children who lived in 34 selected villages in Chiang Rai Province, Thailand. A validated questionnaire was administered, and 3-mL blood specimens were collected. Antibodies against hepatitis B surface antigen (anti-HBs), hepatitis B core antigen (anti-HBc), measles, Japanese encephalitis virus (JEV), and tetanus were detected. Chi-square tests were performed to detect the different proportion of patients with antibodies wit...
Source: Vaccine - October 5, 2021 Category: Allergy & Immunology Authors: Peeradone Srichan Usa Thohinung Salisa Kodyee Tawatchai Apidechkul Source Type: research

Factors influencing adverse events following immunization with AZD1222 in Vietnamese adults during first half of 2021
CONCLUSIONS: This study provides a detailed assessment of risk factors associated with AEFI in Vietnamese people vaccinated with AZD1222. It seems that gender, age and vaccine doses are important factors affecting AEFI.PMID:34607748 | PMC:PMC8485226 | DOI:10.1016/j.vaccine.2021.09.060 (Source: Vaccine)
Source: Vaccine - October 5, 2021 Category: Allergy & Immunology Authors: Van Nhi Tran Hoang An Nguyen Thi Thanh An Le Thanh Tung Truong Phuong Thao Nguyen Thi Thu Hoai Nguyen Source Type: research

Vaccine serocoverage under the expanded program on immunization among hill tribe children in Thailand: A cross-sectional study
This study aimed to assess serocoverage under the EPI and access to vaccination clinics.METHODS: A cross-sectional study was performed to assess serocoverage after childhood vaccination among hill tribe children who lived in 34 selected villages in Chiang Rai Province, Thailand. A validated questionnaire was administered, and 3-mL blood specimens were collected. Antibodies against hepatitis B surface antigen (anti-HBs), hepatitis B core antigen (anti-HBc), measles, Japanese encephalitis virus (JEV), and tetanus were detected. Chi-square tests were performed to detect the different proportion of patients with antibodies wit...
Source: Vaccine - October 5, 2021 Category: Allergy & Immunology Authors: Peeradone Srichan Usa Thohinung Salisa Kodyee Tawatchai Apidechkul Source Type: research

Factors influencing adverse events following immunization with AZD1222 in Vietnamese adults during first half of 2021
CONCLUSIONS: This study provides a detailed assessment of risk factors associated with AEFI in Vietnamese people vaccinated with AZD1222. It seems that gender, age and vaccine doses are important factors affecting AEFI.PMID:34607748 | PMC:PMC8485226 | DOI:10.1016/j.vaccine.2021.09.060 (Source: Vaccine)
Source: Vaccine - October 5, 2021 Category: Allergy & Immunology Authors: Van Nhi Tran Hoang An Nguyen Thi Thanh An Le Thanh Tung Truong Phuong Thao Nguyen Thi Thu Hoai Nguyen Source Type: research

Vaccine serocoverage under the expanded program on immunization among hill tribe children in Thailand: A cross-sectional study
This study aimed to assess serocoverage under the EPI and access to vaccination clinics.METHODS: A cross-sectional study was performed to assess serocoverage after childhood vaccination among hill tribe children who lived in 34 selected villages in Chiang Rai Province, Thailand. A validated questionnaire was administered, and 3-mL blood specimens were collected. Antibodies against hepatitis B surface antigen (anti-HBs), hepatitis B core antigen (anti-HBc), measles, Japanese encephalitis virus (JEV), and tetanus were detected. Chi-square tests were performed to detect the different proportion of patients with antibodies wit...
Source: Vaccine - October 5, 2021 Category: Allergy & Immunology Authors: Peeradone Srichan Usa Thohinung Salisa Kodyee Tawatchai Apidechkul Source Type: research

Factors influencing adverse events following immunization with AZD1222 in Vietnamese adults during first half of 2021
CONCLUSIONS: This study provides a detailed assessment of risk factors associated with AEFI in Vietnamese people vaccinated with AZD1222. It seems that gender, age and vaccine doses are important factors affecting AEFI.PMID:34607748 | DOI:10.1016/j.vaccine.2021.09.060 (Source: Vaccine)
Source: Vaccine - October 5, 2021 Category: Allergy & Immunology Authors: Van Nhi Tran Hoang An Nguyen Thi Thanh An Le Thanh Tung Truong Phuong Thao Nguyen Thi Thu Hoai Nguyen Source Type: research

Recurrent lipoatrophy following multiple vaccinations: A case study
Vaccine. 2021 Sep 30:S0264-410X(21)01237-8. doi: 10.1016/j.vaccine.2021.09.046. Online ahead of print.NO ABSTRACTPMID:34602300 | DOI:10.1016/j.vaccine.2021.09.046 (Source: Vaccine)
Source: Vaccine - October 4, 2021 Category: Allergy & Immunology Authors: G Lewis T Lazzaro N W Crawford Source Type: research

Weaker protection against tuberculosis in BCG-vaccinated male 129 S2 mice compared to females
In conclusion, we found sex-specific differences in response to M. tuberculosis H37Rv -challenge in BCG-vaccinated 129 S2 mice. This highlights the need to include both male and female mice in preclinical testing of vaccine candidates.PMID:34602301 | DOI:10.1016/j.vaccine.2021.09.039 (Source: Vaccine)
Source: Vaccine - October 4, 2021 Category: Allergy & Immunology Authors: Natalie E Nieuwenhuizen Joanna Zyla Ulrike Zedler Silke Bandermann Ulrike Abu Abed Volker Brinkmann Stefan H E Kaufmann Source Type: research

A Research and Development (R & amp;D) roadmap for influenza vaccines: Looking toward the future
This report summarizes the major issues and priority areas of research outlined in the IVR. By identifying the key issues and steps to address them, the roadmap not only encourages research aimed at new solutions, but also provides guidance on the use of innovative tools to drive breakthroughs in influenza vaccine R&D.PMID:34602302 | DOI:10.1016/j.vaccine.2021.08.010 (Source: Vaccine)
Source: Vaccine - October 4, 2021 Category: Allergy & Immunology Authors: Kristine A Moore Julia T Ostrowsky Alison M Kraigsley Angela J Mehr Joseph S Bresee Martin H Friede Bruce G Gellin Josephine P Golding Peter J Hart Ann Moen Charlotte L Weller Michael T Osterholm Influenza Vaccines R & D Roadmap Taskforce Source Type: research

Recurrent lipoatrophy following multiple vaccinations: A case study
Vaccine. 2021 Sep 30:S0264-410X(21)01237-8. doi: 10.1016/j.vaccine.2021.09.046. Online ahead of print.NO ABSTRACTPMID:34602300 | DOI:10.1016/j.vaccine.2021.09.046 (Source: Vaccine)
Source: Vaccine - October 4, 2021 Category: Allergy & Immunology Authors: G Lewis T Lazzaro N W Crawford Source Type: research

Weaker protection against tuberculosis in BCG-vaccinated male 129 S2 mice compared to females
In conclusion, we found sex-specific differences in response to M. tuberculosis H37Rv -challenge in BCG-vaccinated 129 S2 mice. This highlights the need to include both male and female mice in preclinical testing of vaccine candidates.PMID:34602301 | DOI:10.1016/j.vaccine.2021.09.039 (Source: Vaccine)
Source: Vaccine - October 4, 2021 Category: Allergy & Immunology Authors: Natalie E Nieuwenhuizen Joanna Zyla Ulrike Zedler Silke Bandermann Ulrike Abu Abed Volker Brinkmann Stefan H E Kaufmann Source Type: research

A Research and Development (R & amp;D) roadmap for influenza vaccines: Looking toward the future
This report summarizes the major issues and priority areas of research outlined in the IVR. By identifying the key issues and steps to address them, the roadmap not only encourages research aimed at new solutions, but also provides guidance on the use of innovative tools to drive breakthroughs in influenza vaccine R&D.PMID:34602302 | DOI:10.1016/j.vaccine.2021.08.010 (Source: Vaccine)
Source: Vaccine - October 4, 2021 Category: Allergy & Immunology Authors: Kristine A Moore Julia T Ostrowsky Alison M Kraigsley Angela J Mehr Joseph S Bresee Martin H Friede Bruce G Gellin Josephine P Golding Peter J Hart Ann Moen Charlotte L Weller Michael T Osterholm Influenza Vaccines R & D Roadmap Taskforce Source Type: research

Antibody response after first and second-dose of ChAdOx1-nCOV (Covishield < sup > TM < /sup > ®) and BBV-152 (Covaxin < sup > TM < /sup > ®) among health care workers in India: The final results of cross-sectional coronavirus vaccine-induced antibody titre (COVAT) study
CONCLUSIONS: Both vaccines elicited good immune response after two doses, although seropositivity rates and GMT of anti-spike antibody titre was significantly higher in Covishield compared to Covaxin recipients.PMID:34600747 | DOI:10.1016/j.vaccine.2021.09.055 (Source: Vaccine)
Source: Vaccine - October 3, 2021 Category: Allergy & Immunology Authors: Awadhesh Kumar Singh Sanjeev Ratnakar Phatak Ritu Singh Kingshuk Bhattacharjee Nagendra Kumar Singh Arvind Gupta Arvind Sharma Source Type: research