Factors associated with maternal tetanus vaccination in Myanmar: An analysis of demographic and health survey data
Vaccine. 2022 Jan 20:S0264-410X(22)00042-1. doi: 10.1016/j.vaccine.2022.01.018. Online ahead of print.ABSTRACTBACKGROUND: Tetanus toxoid vaccination is a life-saving maternal and child health intervention. Understanding gaps in maternal vaccination coverage is key to informing progress towards universal health coverage. We assessed the vaccination coverage in Myanmar and investigated factors associated with being unvaccinated.METHOD: In this cross-sectional analysis of 2015-16 Demographic and Health Survey data including women aged 15-49 years with at least one childbirth in the last five years. The outcome maternal tetanu...
Source: Vaccine - January 24, 2022 Category: Allergy & Immunology Authors: Zaw Myo Tun Zau Ring Clarence C Tam Source Type: research

COVID-19 vaccine reactogenicity - A cohort event monitoring study in the Netherlands using patient reported outcomes
Vaccine. 2022 Jan 17:S0264-410X(22)00028-7. doi: 10.1016/j.vaccine.2022.01.013. Online ahead of print.ABSTRACTOBJECTIVES: To explore factors that are associated with reactogenicity in general and systemic after the first dose of COVID-19 vaccine in the Netherlands.DESIGN: A web-based prospective cohort design using patient reported outcomes (PROs).SETTING: Any person who has been vaccinated with any brand of COVID-19 vaccine in the Dutch COVID immunization programme.PARTICIPANTS: 22,184 participants. Of these, 13,959 (62.9%) experienced reactogenicity in general and 11,979 (54.0%) systemic reactogenicity within 7 days afte...
Source: Vaccine - January 24, 2022 Category: Allergy & Immunology Authors: Le àn Rolfes Linda H ärmark Agnes Kant Leontine van Balveren Wil Hilgersom Florence van Hunsel Source Type: research

Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in Beijing: A modeling analysis
CONCLUSION: The introduction of QIVs to school children, elderly adults, or HCWs is likely to be cost-effective, either separately or collectively. The introduction of QIV to school children, elderly adults, and health care workers simultaneously showed the highest probability of being cost-effective and was the preferred option.PMID:35065820 | DOI:10.1016/j.vaccine.2022.01.006 (Source: Vaccine)
Source: Vaccine - January 23, 2022 Category: Allergy & Immunology Authors: Dawei Zhu Min Lv Yunhua Bai Jiang Wu Ping He Source Type: research

Letter to the Editor: Waiting period of the European Pet Travel Scheme (EU-PETS)
Vaccine. 2022 Jan 20:S0264-410X(22)00041-X. doi: 10.1016/j.vaccine.2022.01.017. Online ahead of print.NO ABSTRACTPMID:35065821 | DOI:10.1016/j.vaccine.2022.01.017 (Source: Vaccine)
Source: Vaccine - January 23, 2022 Category: Allergy & Immunology Authors: R G Zanoni Source Type: research

Adolescents' attitudes to the COVID-19 vaccination
This study has proved that even in adolescents the vaccine hesitancy model is prominent with adolescents' intentions highly related to confidence in the vaccine and perception of disease risk. Future interventions should target these specific concerns to ensure adolescents are well educated to overcome vaccine hesitancy.PMID:35063284 | DOI:10.1016/j.vaccine.2022.01.010 (Source: Vaccine)
Source: Vaccine - January 22, 2022 Category: Allergy & Immunology Authors: W H S Wong D Leung G T Chua J S R Duque S Peare H K So S M Chan M Y W Kwan P Ip Y L Lau Source Type: research

Safety and immunogenicity studies in animal models support clinical development of a bivalent norovirus-like particle vaccine produced in plants
Vaccine. 2022 Jan 18:S0264-410X(22)00022-6. doi: 10.1016/j.vaccine.2022.01.009. Online ahead of print.ABSTRACTNoroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide. A safe and effective vaccine that prevents NoV infection or minimizes NoV disease burden is needed, especially for children and the elderly who are particularly susceptible to NoV disease. A plant-based expression system (magnICON®) was used to manufacture two different virus-like particle (VLP) immunogens derived from human NoV genogroups I and II, genotype 4 (GI.4 and GII.4), which were subsequently blended 1:1 (w/w...
Source: Vaccine - January 22, 2022 Category: Allergy & Immunology Authors: Daniel Tus é Maria Malm Kirsi Tamminen Andr é Diessner Frank Thieme Franziska Jarczowski Vesna Blazevic Victor Klimyuk Source Type: research

Adolescents' attitudes to the COVID-19 vaccination
This study has proved that even in adolescents the vaccine hesitancy model is prominent with adolescents' intentions highly related to confidence in the vaccine and perception of disease risk. Future interventions should target these specific concerns to ensure adolescents are well educated to overcome vaccine hesitancy.PMID:35063284 | DOI:10.1016/j.vaccine.2022.01.010 (Source: Vaccine)
Source: Vaccine - January 22, 2022 Category: Allergy & Immunology Authors: W H S Wong D Leung G T Chua J S R Duque S Peare H K So S M Chan M Y W Kwan P Ip Y L Lau Source Type: research

Safety and immunogenicity studies in animal models support clinical development of a bivalent norovirus-like particle vaccine produced in plants
Vaccine. 2022 Jan 18:S0264-410X(22)00022-6. doi: 10.1016/j.vaccine.2022.01.009. Online ahead of print.ABSTRACTNoroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide. A safe and effective vaccine that prevents NoV infection or minimizes NoV disease burden is needed, especially for children and the elderly who are particularly susceptible to NoV disease. A plant-based expression system (magnICON®) was used to manufacture two different virus-like particle (VLP) immunogens derived from human NoV genogroups I and II, genotype 4 (GI.4 and GII.4), which were subsequently blended 1:1 (w/w...
Source: Vaccine - January 22, 2022 Category: Allergy & Immunology Authors: Daniel Tus é Maria Malm Kirsi Tamminen Andr é Diessner Frank Thieme Franziska Jarczowski Vesna Blazevic Victor Klimyuk Source Type: research

Annual trends in adverse events following mumps vaccination in Japan: A retrospective study
CONCLUSION: The incidence of post-vaccination aseptic meningitis has declined significantly since 2001, and the incidence has remained stable at fewer than 3 cases per 100,000 doses since 2010. Multiple factors might have contributed to the decline in aseptic meningitis incidence, including (i) lowered misclassification of aseptic meningitis resulting from echovirus infection; (ii) changes in the vaccine manufacturing process in 2000; and (iii) publication in 2008 of the recommendation for vaccination of children at 1 year of age.PMID:35058077 | DOI:10.1016/j.vaccine.2022.01.008 (Source: Vaccine)
Source: Vaccine - January 21, 2022 Category: Allergy & Immunology Authors: Satoko Ohfuji Takaaki Tanaka Takashi Nakano Tetsuo Kase Kyoko Kondo Wakaba Fukushima Yoshio Hirota Source Type: research

Annual trends in adverse events following mumps vaccination in Japan: A retrospective study
CONCLUSION: The incidence of post-vaccination aseptic meningitis has declined significantly since 2001, and the incidence has remained stable at fewer than 3 cases per 100,000 doses since 2010. Multiple factors might have contributed to the decline in aseptic meningitis incidence, including (i) lowered misclassification of aseptic meningitis resulting from echovirus infection; (ii) changes in the vaccine manufacturing process in 2000; and (iii) publication in 2008 of the recommendation for vaccination of children at 1 year of age.PMID:35058077 | DOI:10.1016/j.vaccine.2022.01.008 (Source: Vaccine)
Source: Vaccine - January 21, 2022 Category: Allergy & Immunology Authors: Satoko Ohfuji Takaaki Tanaka Takashi Nakano Tetsuo Kase Kyoko Kondo Wakaba Fukushima Yoshio Hirota Source Type: research

COVID-19 vaccine uptake, effectiveness, and waning in 82,959 health care workers: A national prospective cohort study in Wales
CONCLUSIONS: With some variation in rate of uptake, those who were vaccinated had a reduced risk of PCR-confirmed SARS-CoV-2 infection, compared to those unvaccinated. Second dose has provided stronger protection for longer than first dose but our study is consistent with waning from seven weeks onwards.PMID:35042645 | PMC:PMC8760602 | DOI:10.1016/j.vaccine.2021.11.061 (Source: Vaccine)
Source: Vaccine - January 19, 2022 Category: Allergy & Immunology Authors: Stuart Bedston Ashley Akbari Christopher I Jarvis Emily Lowthian Fatemeh Torabi Laura North Jane Lyons Malorie Perry Lucy J Griffiths Rhiannon K Owen Jillian Beggs Antony Chuter Declan T Bradley Simon de Lusignan Richard Fry F D Richard Hobbs Joe Hollingh Source Type: research

Understanding COVID-19 vaccination willingness among youth: A survey study in the Netherlands
Vaccine. 2022 Jan 5:S0264-410X(21)01670-4. doi: 10.1016/j.vaccine.2021.12.062. Online ahead of print.ABSTRACTVaccination of youth could be key to preventing future outbreaks of SARS-CoV-2. Given the limited direct health benefit for young people, it is important to understand how youth themselves perceive obtaining a vaccination. This survey study in a representative sample of Dutch youth aged 12-18 showed that 73% were willing to get vaccinated against COVID-19. In regression analyses, vaccination willingness was strongly related to age, perceived personal (protect own health) and societal benefits (to get rid of restrict...
Source: Vaccine - January 19, 2022 Category: Allergy & Immunology Authors: Saskia Euser Floor M Kroese Mare Derks Marijn de Bruin Source Type: research

COVID-19 vaccine uptake, effectiveness, and waning in 82,959 health care workers: A national prospective cohort study in Wales
CONCLUSIONS: With some variation in rate of uptake, those who were vaccinated had a reduced risk of PCR-confirmed SARS-CoV-2 infection, compared to those unvaccinated. Second dose has provided stronger protection for longer than first dose but our study is consistent with waning from seven weeks onwards.PMID:35042645 | PMC:PMC8760602 | DOI:10.1016/j.vaccine.2021.11.061 (Source: Vaccine)
Source: Vaccine - January 19, 2022 Category: Allergy & Immunology Authors: Stuart Bedston Ashley Akbari Christopher I Jarvis Emily Lowthian Fatemeh Torabi Laura North Jane Lyons Malorie Perry Lucy J Griffiths Rhiannon K Owen Jillian Beggs Antony Chuter Declan T Bradley Simon de Lusignan Richard Fry F D Richard Hobbs Joe Hollingh Source Type: research

Understanding COVID-19 vaccination willingness among youth: A survey study in the Netherlands
Vaccine. 2022 Jan 5:S0264-410X(21)01670-4. doi: 10.1016/j.vaccine.2021.12.062. Online ahead of print.ABSTRACTVaccination of youth could be key to preventing future outbreaks of SARS-CoV-2. Given the limited direct health benefit for young people, it is important to understand how youth themselves perceive obtaining a vaccination. This survey study in a representative sample of Dutch youth aged 12-18 showed that 73% were willing to get vaccinated against COVID-19. In regression analyses, vaccination willingness was strongly related to age, perceived personal (protect own health) and societal benefits (to get rid of restrict...
Source: Vaccine - January 19, 2022 Category: Allergy & Immunology Authors: Saskia Euser Floor M Kroese Mare Derks Marijn de Bruin Source Type: research

COVID-19 and missed or delayed vaccination in 26 middle- and high-income countries: An observational survey
Vaccine. 2021 Dec 21:S0264-410X(21)01649-2. doi: 10.1016/j.vaccine.2021.12.041. Online ahead of print.ABSTRACTBACKGROUND: The COVID-19 pandemic has disrupted vaccination services and raised the risk of a global resurgence of preventable diseases. We assessed the extent of and reasons for missed or delayed vaccinations (hereafter 'missed') in middle- and high-income countries in the early months of the pandemic.METHODS: From May to June 2020, participants completed an online survey on missed vaccination. Analyses separated missed childhood and adult vaccination in middle-and high-income countries.RESULTS: Respondents were 2...
Source: Vaccine - January 18, 2022 Category: Allergy & Immunology Authors: Gilla K Shapiro Nisha Gottfredson Julie Leask Kerrie Wiley Francine E Ganter-Restrepo Sarah P Jones Lisa Menning Noel T Brewer Source Type: research

Lot-to-lot consistency, safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in healthy adults aged ≥50 years: A randomized phase 3 trial (PNEU-TRUE)
CONCLUSIONS: V114 is well tolerated with a consistent safety profile and immune response across manufacturing lots.CLINICAL TRIALS REGISTRATION: NCT03950856 (www.clinicaltrials.gov); 2018-004266-33 (EudraCT).PMID:35039194 | DOI:10.1016/j.vaccine.2021.12.067 (Source: Vaccine)
Source: Vaccine - January 18, 2022 Category: Allergy & Immunology Authors: Jakub K Simon Nina Breinholt Staerke Maria Hemming-Harlo Stacey Layle Ron Dagan Tulin Shekar Alison Pedley Patricia Jumes Gretchen Tamms Tina Sterling Luwy Musey Ulrike K Buchwald V114-020 PNEU-TRUE study group Source Type: research

Cost-effectiveness of pertussis booster vaccination for preschool children in Japan
CONCLUSION: The introduction of a DTaP booster vaccination to the routine immunization schedule can be expected to reduce the number of pertussis cases in the target population. However, our study showed that adding a booster vaccination for 6-year-old children to the schedule in Japan would not be cost-effective in terms of achieving herd immunity among unvaccinated infants.PMID:35039195 | DOI:10.1016/j.vaccine.2022.01.001 (Source: Vaccine)
Source: Vaccine - January 18, 2022 Category: Allergy & Immunology Authors: Motoko Tanaka Reiko Okubo Shu-Ling Hoshi Nobuyuki Ishikawa Masahide Kondo Source Type: research

COVID-19 and missed or delayed vaccination in 26 middle- and high-income countries: An observational survey
Vaccine. 2021 Dec 21:S0264-410X(21)01649-2. doi: 10.1016/j.vaccine.2021.12.041. Online ahead of print.ABSTRACTBACKGROUND: The COVID-19 pandemic has disrupted vaccination services and raised the risk of a global resurgence of preventable diseases. We assessed the extent of and reasons for missed or delayed vaccinations (hereafter 'missed') in middle- and high-income countries in the early months of the pandemic.METHODS: From May to June 2020, participants completed an online survey on missed vaccination. Analyses separated missed childhood and adult vaccination in middle-and high-income countries.RESULTS: Respondents were 2...
Source: Vaccine - January 18, 2022 Category: Allergy & Immunology Authors: Gilla K Shapiro Nisha Gottfredson Julie Leask Kerrie Wiley Francine E Ganter-Restrepo Sarah P Jones Lisa Menning Noel T Brewer Source Type: research

Lot-to-lot consistency, safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in healthy adults aged ≥50 years: A randomized phase 3 trial (PNEU-TRUE)
CONCLUSIONS: V114 is well tolerated with a consistent safety profile and immune response across manufacturing lots.CLINICAL TRIALS REGISTRATION: NCT03950856 (www.clinicaltrials.gov); 2018-004266-33 (EudraCT).PMID:35039194 | DOI:10.1016/j.vaccine.2021.12.067 (Source: Vaccine)
Source: Vaccine - January 18, 2022 Category: Allergy & Immunology Authors: Jakub K Simon Nina Breinholt Staerke Maria Hemming-Harlo Stacey Layle Ron Dagan Tulin Shekar Alison Pedley Patricia Jumes Gretchen Tamms Tina Sterling Luwy Musey Ulrike K Buchwald V114-020 PNEU-TRUE study group Source Type: research

Cost-effectiveness of pertussis booster vaccination for preschool children in Japan
CONCLUSION: The introduction of a DTaP booster vaccination to the routine immunization schedule can be expected to reduce the number of pertussis cases in the target population. However, our study showed that adding a booster vaccination for 6-year-old children to the schedule in Japan would not be cost-effective in terms of achieving herd immunity among unvaccinated infants.PMID:35039195 | DOI:10.1016/j.vaccine.2022.01.001 (Source: Vaccine)
Source: Vaccine - January 18, 2022 Category: Allergy & Immunology Authors: Motoko Tanaka Reiko Okubo Shu-Ling Hoshi Nobuyuki Ishikawa Masahide Kondo Source Type: research

Vaccine misinformation types and properties in Russian troll tweets
Vaccine. 2022 Jan 13:S0264-410X(21)01648-0. doi: 10.1016/j.vaccine.2021.12.040. Online ahead of print.ABSTRACTOBJECTIVE: To identify the content of and engagement with vaccine misinformation from Russian trolls on Twitter.METHODS: Troll tweets (N = 1959) obtained from Twitter in 2020 were coded for vaccine misinformation (α = 0.77-0.97). Descriptive, bivariate, and multivariable negative binomial regressions were applied to estimate robust incidence rate ratios (IRRs) and 95% confidence intervals (95 %CI) of vaccine misinformation associations with tweet characteristics and engagement (i.e., replies, likes, retweets)...
Source: Vaccine - January 17, 2022 Category: Allergy & Immunology Authors: Echo L Warner Juliana L Barbati Kaylin L Duncan Kun Yan Stephen A Rains Source Type: research

Variability in non-core vaccination rates of dogs and cats in veterinary clinics across the United States
Vaccine. 2022 Jan 13:S0264-410X(22)00006-8. doi: 10.1016/j.vaccine.2022.01.003. Online ahead of print.ABSTRACTVaccination guidelines for dogs and cats indicate that core vaccines (for dogs, rabies, distemper, adenovirus, parvovirus; for cats, feline parvovirus, herpes virus-1, calicivirus) are essential to maintain health, and that non-core vaccines be administered according to a clinician's assessment of a pet's risk of exposure and susceptibility to infection. A reliance on individual risk assessment introduces the potential for between-practice inconsistencies in non-core vaccine recommendations. A study was initiated t...
Source: Vaccine - January 17, 2022 Category: Allergy & Immunology Authors: Kyle B Malter Mara E Tugel Maria Gil-Rodriguez Guillermo de la Guardia Sally W Jackson William G Ryan George E Moore Source Type: research

Factors associated with COVID-19 vaccination intentions among adults in the deep South
Vaccine. 2022 Jan 10:S0264-410X(21)01667-4. doi: 10.1016/j.vaccine.2021.12.059. Online ahead of print.ABSTRACTThe recent approval of several COVID-19 vaccines signals progress toward controlling the pandemic. Although social distancing and masking have been effective, vaccines are an important additional measure of protection to reduce COVID-19 spread. Adequate uptake is essential to reach herd immunity, estimated to be approximately 67%. However, vaccine hesitancy, the fast-tracked nature of the COVID-19 vaccines, and misinformation circulating through various forms of media have contributed to lower vaccination intention...
Source: Vaccine - January 17, 2022 Category: Allergy & Immunology Authors: Casey L Daniel Jacob Williams Rachel Legg Chelsea McGowen Jesse Stutzman Source Type: research

Vaccine misinformation types and properties in Russian troll tweets
Vaccine. 2022 Jan 13:S0264-410X(21)01648-0. doi: 10.1016/j.vaccine.2021.12.040. Online ahead of print.ABSTRACTOBJECTIVE: To identify the content of and engagement with vaccine misinformation from Russian trolls on Twitter.METHODS: Troll tweets (N = 1959) obtained from Twitter in 2020 were coded for vaccine misinformation (α = 0.77-0.97). Descriptive, bivariate, and multivariable negative binomial regressions were applied to estimate robust incidence rate ratios (IRRs) and 95% confidence intervals (95 %CI) of vaccine misinformation associations with tweet characteristics and engagement (i.e., replies, likes, retweets)...
Source: Vaccine - January 17, 2022 Category: Allergy & Immunology Authors: Echo L Warner Juliana L Barbati Kaylin L Duncan Kun Yan Stephen A Rains Source Type: research

Variability in non-core vaccination rates of dogs and cats in veterinary clinics across the United States
Vaccine. 2022 Jan 13:S0264-410X(22)00006-8. doi: 10.1016/j.vaccine.2022.01.003. Online ahead of print.ABSTRACTVaccination guidelines for dogs and cats indicate that core vaccines (for dogs, rabies, distemper, adenovirus, parvovirus; for cats, feline parvovirus, herpes virus-1, calicivirus) are essential to maintain health, and that non-core vaccines be administered according to a clinician's assessment of a pet's risk of exposure and susceptibility to infection. A reliance on individual risk assessment introduces the potential for between-practice inconsistencies in non-core vaccine recommendations. A study was initiated t...
Source: Vaccine - January 17, 2022 Category: Allergy & Immunology Authors: Kyle B Malter Mara E Tugel Maria Gil-Rodriguez Guillermo de la Guardia Sally W Jackson William G Ryan George E Moore Source Type: research

Factors associated with COVID-19 vaccination intentions among adults in the deep South
Vaccine. 2022 Jan 10:S0264-410X(21)01667-4. doi: 10.1016/j.vaccine.2021.12.059. Online ahead of print.ABSTRACTThe recent approval of several COVID-19 vaccines signals progress toward controlling the pandemic. Although social distancing and masking have been effective, vaccines are an important additional measure of protection to reduce COVID-19 spread. Adequate uptake is essential to reach herd immunity, estimated to be approximately 67%. However, vaccine hesitancy, the fast-tracked nature of the COVID-19 vaccines, and misinformation circulating through various forms of media have contributed to lower vaccination intention...
Source: Vaccine - January 17, 2022 Category: Allergy & Immunology Authors: Casey L Daniel Jacob Williams Rachel Legg Chelsea McGowen Jesse Stutzman Source Type: research

COVID-19 and Routine Childhood and Adolescent Immunizations: Evidence from Louisiana Medicaid
Vaccine. 2021 Dec 24:S0264-410X(21)01630-3. doi: 10.1016/j.vaccine.2021.12.022. Online ahead of print.ABSTRACTThe COVID-19 pandemic disrupted routine vaccinations for children and adolescents. However, it remains unclear whether the impact has been different for children and adolescents from low-income families. To address this, we compared monthly routine vaccination use per 1000 vaccine-eligible children and adolescents enrolled in Louisiana Medicaid in the years before (2017-2019) and during the COVID-19 pandemic (2020). Compared to the 2017-2019 average vaccination rates, we found a 28% reduction in measles, mumps, and...
Source: Vaccine - January 16, 2022 Category: Allergy & Immunology Authors: Brigham Walker Andrew Anderson Charles Stoecker Yixue Shao Thomas A LaVeist Kevin Callison Source Type: research

Variation in influenza vaccine assessment, receipt, and refusal by the concentration of Medicare Advantage enrollees in U.S. nursing homes
CONCLUSION: A higher concentration of long-stay NH residents enrolled in MA was associated with greater influenza vaccine receipt and lower vaccine refusal. As MA becomes a larger share of the Medicare program, and more MA beneficiaries enter NHs, decisionmakers need to consider how managed care can be leveraged to improve the delivery of preventive services like influenza vaccinations in NH settings.PMID:35033387 | DOI:10.1016/j.vaccine.2021.12.069 (Source: Vaccine)
Source: Vaccine - January 16, 2022 Category: Allergy & Immunology Authors: Patience Moyo Elliott Bosco Barbara H Bardenheier Maricruz Rivera-Hernandez Robertus van Aalst Ayman Chit Stefan Gravenstein Andrew R Zullo Source Type: research

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
Vaccine. 2022 Jan 13:S0264-410X(21)01676-5. doi: 10.1016/j.vaccine.2021.12.068. Online ahead of print.ABSTRACTStreptococcus pneumoniae (S. pneumoniae)infections are the leading cause of child mortality globally. Currentvaccines fail to induceaprotective immune response towards a conserved part of the pathogen,resulting in newserotypescausing disease. Therefore, new vaccinestrategies are urgently needed.Described is atwo-pronged approach combiningS. pneumoniaeproteins, pneumolysin (Ply) and pneumococcal surface protein A (PspA),with aprecisely defined synthetic oligosaccharide,wherebythe carrier protein actsas a serotype-in...
Source: Vaccine - January 16, 2022 Category: Allergy & Immunology Authors: Paulina Kaplonek Ling Yao Katrin Reppe Franziska Vo ß Thomas Kohler Friederike Ebner Alexander Sch äfer Ulrike Blohm Patricia Priegue Maria Br äutigam Claney L Pereira Sharavathi G Parameswarappa Madhu Emmadi Petra M énová Martin Witzenrath Sven Hamm Source Type: research

Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staff
DISCUSSION: A favorable antibody response was observed after two doses of BNT162b2 vaccination among mostly healthy Japanese participants, especially among female and young participants. Although further investigation is essential, our results imply that the systemic adverse reactions (i.e., fever and general fatigue) are associated with a higher antibody response that indicates the acquisition of humoral immunity.PMID:35033389 | DOI:10.1016/j.vaccine.2022.01.002 (Source: Vaccine)
Source: Vaccine - January 16, 2022 Category: Allergy & Immunology Authors: Yoshifumi Uwamino Toshinobu Kurafuji Yasunori Sato Yukari Tomita Ayako Shibata Akiko Tanabe Yoko Yatabe Masayo Noguchi Tomoko Arai Akemi Ohno Hiromitsu Yokota Wakako Yamasawa Shunsuke Uno Tomoyasu Nishimura Naoki Hasegawa Hideyuki Saya Masatoshi Wakui Mit Source Type: research

Immune interference revisited: Impact of live-attenuated influenza vaccine prior to yellow fever vaccination
Vaccine. 2022 Jan 11:S0264-410X(21)01637-6. doi: 10.1016/j.vaccine.2021.12.031. Online ahead of print.ABSTRACTBACKGROUND: During routine mass live-attenuated influenza vaccination (LAIV) for military personnel, emergent deployment for Ebola humanitarian assistance (OUA) required mass yellow fever vaccination (YF17D), often
Source: Vaccine - January 15, 2022 Category: Allergy & Immunology Authors: Dana M Blyth Zhaodong Liang Maya Williams Clinton K Murray Source Type: research

Performance and usability evaluation of novel intradermal injection device Immucise ™ and reanalysis of intradermal administration trials of influenza vaccine for the elderly
This study showed that Immucise™ can reduce dead volume and inject drugs precisely into the ID tissues of subjects from infants to the elderly and can be used correctly and safely by healthcare professionals. This randomized controlled trial compared ID administration with Immucise™ and standard subcutaneous (SC) administration of seasonal influenza vaccine by analyzing the efficacy of the vaccine in the elderly group at 90 days and 180 days after administration. It was found that the vaccine for the ID group was as effective or more effective than that for the SC group up to 180 days later. It was also found t...
Source: Vaccine - January 15, 2022 Category: Allergy & Immunology Authors: Sakiko Shimizu Ryo Tanaka Eriko Itoh Minami Maekawa-Matsuura Yoichiro Iwase Source Type: research

Postmarketing safety surveillance of high-dose quadrivalent influenza vaccine: Reports to the Vaccine Adverse Event Reporting System
Vaccine. 2022 Jan 11:S0264-410X(22)00001-9. doi: 10.1016/j.vaccine.2021.12.070. Online ahead of print.ABSTRACTOn November 4, 2019, the Food and Drug Administration approved high-dose quadrivalent influenza vaccine (Fluzone High-Dose Quadrivalent; QIV-HD) for active immunization for the prevention of influenza disease in individuals 65 years of age and older. A prelicensure randomized, active-controlled, modified double-blind trial did not reveal any major differences in adverse events following QIV-HD versus Fluzone High-Dose (trivalent). To improve our understanding of the safety profile of QIV-HD, we reviewed and summari...
Source: Vaccine - January 15, 2022 Category: Allergy & Immunology Authors: Emily Jane Woo Pedro L Moro Source Type: research

Immune interference revisited: Impact of live-attenuated influenza vaccine prior to yellow fever vaccination
Vaccine. 2022 Jan 11:S0264-410X(21)01637-6. doi: 10.1016/j.vaccine.2021.12.031. Online ahead of print.ABSTRACTBACKGROUND: During routine mass live-attenuated influenza vaccination (LAIV) for military personnel, emergent deployment for Ebola humanitarian assistance (OUA) required mass yellow fever vaccination (YF17D), often
Source: Vaccine - January 15, 2022 Category: Allergy & Immunology Authors: Dana M Blyth Zhaodong Liang Maya Williams Clinton K Murray Source Type: research

Performance and usability evaluation of novel intradermal injection device Immucise ™ and reanalysis of intradermal administration trials of influenza vaccine for the elderly
This study showed that Immucise™ can reduce dead volume and inject drugs precisely into the ID tissues of subjects from infants to the elderly and can be used correctly and safely by healthcare professionals. This randomized controlled trial compared ID administration with Immucise™ and standard subcutaneous (SC) administration of seasonal influenza vaccine by analyzing the efficacy of the vaccine in the elderly group at 90 days and 180 days after administration. It was found that the vaccine for the ID group was as effective or more effective than that for the SC group up to 180 days later. It was also found t...
Source: Vaccine - January 15, 2022 Category: Allergy & Immunology Authors: Sakiko Shimizu Ryo Tanaka Eriko Itoh Minami Maekawa-Matsuura Yoichiro Iwase Source Type: research

Postmarketing safety surveillance of high-dose quadrivalent influenza vaccine: Reports to the Vaccine Adverse Event Reporting System
Vaccine. 2022 Jan 11:S0264-410X(22)00001-9. doi: 10.1016/j.vaccine.2021.12.070. Online ahead of print.ABSTRACTOn November 4, 2019, the Food and Drug Administration approved high-dose quadrivalent influenza vaccine (Fluzone High-Dose Quadrivalent; QIV-HD) for active immunization for the prevention of influenza disease in individuals 65 years of age and older. A prelicensure randomized, active-controlled, modified double-blind trial did not reveal any major differences in adverse events following QIV-HD versus Fluzone High-Dose (trivalent). To improve our understanding of the safety profile of QIV-HD, we reviewed and summari...
Source: Vaccine - January 15, 2022 Category: Allergy & Immunology Authors: Emily Jane Woo Pedro L Moro Source Type: research

Optimizing vaccine distribution via mobile clinics: a case study on COVID-19 vaccine distribution to long-term care facilities
CONCLUSIONS: We demonstrate that algorithmic approaches are instrumental in maximizing vaccine distribution efficiency. Our learning and framework may be of use to other organizations, including communities where mobile clinics can be established to efficiently distribute vaccines and other healthcare resources in a variety of scenarios.PMID:35027228 | PMC:PMC8710399 | DOI:10.1016/j.vaccine.2021.12.049 (Source: Vaccine)
Source: Vaccine - January 14, 2022 Category: Allergy & Immunology Authors: Samta Shukla Francois Fressin Michelle Un Henriette Coetzer Sreekanth K Chaguturu Source Type: research

Optimizing vaccine distribution via mobile clinics: a case study on COVID-19 vaccine distribution to long-term care facilities
CONCLUSIONS: We demonstrate that algorithmic approaches are instrumental in maximizing vaccine distribution efficiency. Our learning and framework may be of use to other organizations, including communities where mobile clinics can be established to efficiently distribute vaccines and other healthcare resources in a variety of scenarios.PMID:35027228 | DOI:10.1016/j.vaccine.2021.12.049 (Source: Vaccine)
Source: Vaccine - January 14, 2022 Category: Allergy & Immunology Authors: Samta Shukla Francois Fressin Michelle Un Henriette Coetzer Sreekanth K Chaguturu Source Type: research

Lineage-matched versus mismatched influenza B vaccine effectiveness following seasons of marginal influenza B circulation
CONCLUSIONS: Our results support the rapid transition from the TIV to the QIV.PMID:35016804 | DOI:10.1016/j.vaccine.2021.12.056 (Source: Vaccine)
Source: Vaccine - January 12, 2022 Category: Allergy & Immunology Authors: Itay Omer Alina Rosenberg Hanna Sefty Rakefet Pando Michal Mandelboim Ella Mendelson Lital Keinan-Boker Aharona Glatman-Freedman Israel Influenza Surveillance Network (IISN) Source Type: research

Lineage-matched versus mismatched influenza B vaccine effectiveness following seasons of marginal influenza B circulation
CONCLUSIONS: Our results support the rapid transition from the TIV to the QIV.PMID:35016804 | DOI:10.1016/j.vaccine.2021.12.056 (Source: Vaccine)
Source: Vaccine - January 12, 2022 Category: Allergy & Immunology Authors: Itay Omer Alina Rosenberg Hanna Sefty Rakefet Pando Michal Mandelboim Ella Mendelson Lital Keinan-Boker Aharona Glatman-Freedman Israel Influenza Surveillance Network (IISN) Source Type: research

Protective response mediated by immunization with recombinant proteins in a murine model of toxocariasis and canine infection by Toxocara canis
Vaccine. 2022 Jan 7:S0264-410X(21)01660-1. doi: 10.1016/j.vaccine.2021.12.052. Online ahead of print.ABSTRACTToxocariasis is a neglected parasitic zoonosis of global importance. The development of a formulation that can be used as a vaccine would help the definitive control of the infection. Preclinical studies selected two recombinant T. canis proteins (rTcVcan and rTcCad) which significantly protected mice against larval migration. In the present work, these proteins plus three adjuvants (Alhydrogel®, PAM3CSK4®, and Quil-A®) were used to immunize mice against toxocariasis; blood samples were collected three t...
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Dumar Alexander Jaramillo-Hern ández Luis Fabi án Salazar Garcés Luis Gustavo Carvalho Pacheco Carina Silva Pinheiro Neuza Maria Alcantara-Neves Source Type: research

Impact of the COVID-19 pandemic on pediatric and adolescent vaccinations and well child visits in the United States: A database analysis
CONCLUSIONS: We found substantial disruptions in well child visit attendance and vaccination administration for children and adolescents during the COVID-19 pandemic in 2020 and early 2021. Continued efforts are needed to monitor recovery and catch up to avoid outbreaks and morbidity associated with vaccine-preventable diseases.PMID:35012776 | PMC:PMC8719942 | DOI:10.1016/j.vaccine.2021.12.064 (Source: Vaccine)
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Stephanie A Kujawski Lixia Yao H Echo Wang Cristina Carias Ya-Ting Chen Source Type: research

Safety and effectiveness of BNT162b2 mRNA Covid-19 vaccine in adolescents
Vaccine. 2021 Dec 24:S0264-410X(21)01654-6. doi: 10.1016/j.vaccine.2021.12.044. Online ahead of print.ABSTRACTIn South Korea, all 12th grade students (highs school seniors) were offered BNT162b2 vaccine starting July 19, 2021; while 10th-11th grade students were not eligible. We conducted a nationwide retrospective cohort study by to determine the safety and effectiveness of BNT162b2 mRNA Covid-19 vaccine in adolescents against SARS-CoV-2 infection. Among 444,313 persons who received the first dose of vaccine, reporting rate for myocarditis and/or pericarditis was 1.8 per 100,000 (95% C.I. 0.8-3.5) among first-dose recipie...
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Young June Choe Seonju Yi Insob Hwang Jia Kim Young-Joon Park Eunhee Cho Myoungyoun Jo Hyunju Lee Eun Hwa Choi Source Type: research

A population-based analysis to determine the impact of the 13-valent pneumococcal conjugate vaccine on community-acquired pneumonia in British Columbia, Canada
CONCLUSIONS: The PCV13 infant immunization program is temporally associated with a reduction in CAP incidence in vaccine target age group. However, no significant decrease in CAP incidence in other age groups warrants further study of the etiology of CAP to develop and implement effective prevention programs.PMID:35012778 | DOI:10.1016/j.vaccine.2021.12.065 (Source: Vaccine)
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Nirma K Vadlamudi David M Patrick Caren Rose Mohsen Sadatsafavi Linda Hoang Fawziah Marra Source Type: research

Protective response mediated by immunization with recombinant proteins in a murine model of toxocariasis and canine infection by Toxocara canis
Vaccine. 2022 Jan 7:S0264-410X(21)01660-1. doi: 10.1016/j.vaccine.2021.12.052. Online ahead of print.ABSTRACTToxocariasis is a neglected parasitic zoonosis of global importance. The development of a formulation that can be used as a vaccine would help the definitive control of the infection. Preclinical studies selected two recombinant T. canis proteins (rTcVcan and rTcCad) which significantly protected mice against larval migration. In the present work, these proteins plus three adjuvants (Alhydrogel®, PAM3CSK4®, and Quil-A®) were used to immunize mice against toxocariasis; blood samples were collected three t...
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Dumar Alexander Jaramillo-Hern ández Luis Fabi án Salazar Garcés Luis Gustavo Carvalho Pacheco Carina Silva Pinheiro Neuza Maria Alcantara-Neves Source Type: research

Impact of the COVID-19 pandemic on pediatric and adolescent vaccinations and well child visits in the United States: A database analysis
CONCLUSIONS: We found substantial disruptions in well child visit attendance and vaccination administration for children and adolescents during the COVID-19 pandemic in 2020 and early 2021. Continued efforts are needed to monitor recovery and catch up to avoid outbreaks and morbidity associated with vaccine-preventable diseases.PMID:35012776 | DOI:10.1016/j.vaccine.2021.12.064 (Source: Vaccine)
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Stephanie A Kujawski Lixia Yao H Echo Wang Cristina Carias Ya-Ting Chen Source Type: research

Safety and effectiveness of BNT162b2 mRNA Covid-19 vaccine in adolescents
Vaccine. 2021 Dec 24:S0264-410X(21)01654-6. doi: 10.1016/j.vaccine.2021.12.044. Online ahead of print.ABSTRACTIn South Korea, all 12th grade students (highs school seniors) were offered BNT162b2 vaccine starting July 19, 2021; while 10th-11th grade students were not eligible. We conducted a nationwide retrospective cohort study by to determine the safety and effectiveness of BNT162b2 mRNA Covid-19 vaccine in adolescents against SARS-CoV-2 infection. Among 444,313 persons who received the first dose of vaccine, reporting rate for myocarditis and/or pericarditis was 1.8 per 100,000 (95% C.I. 0.8-3.5) among first-dose recipie...
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Young June Choe Seonju Yi Insob Hwang Jia Kim Young-Joon Park Eunhee Cho Myoungyoun Jo Hyunju Lee Eun Hwa Choi Source Type: research

A population-based analysis to determine the impact of the 13-valent pneumococcal conjugate vaccine on community-acquired pneumonia in British Columbia, Canada
CONCLUSIONS: The PCV13 infant immunization program is temporally associated with a reduction in CAP incidence in vaccine target age group. However, no significant decrease in CAP incidence in other age groups warrants further study of the etiology of CAP to develop and implement effective prevention programs.PMID:35012778 | DOI:10.1016/j.vaccine.2021.12.065 (Source: Vaccine)
Source: Vaccine - January 11, 2022 Category: Allergy & Immunology Authors: Nirma K Vadlamudi David M Patrick Caren Rose Mohsen Sadatsafavi Linda Hoang Fawziah Marra Source Type: research

Longitudinal, population-based cohort study of prenatal influenza vaccination and influenza infection in childhood
Vaccine. 2022 Jan 7:S0264-410X(21)01556-5. doi: 10.1016/j.vaccine.2021.11.084. Online ahead of print.ABSTRACTBACKGROUND: Influenza vaccination is recommended to protect mothers and their infants from influenza infection. Few studies have evaluated the health impacts of in utero exposure to influenza vaccine among children more than six months of age.METHODS: We used probabilistically linked administrative health records to establish a mother-child cohort to evaluate the risk of influenza and acute respiratory infections associated with maternal influenza vaccination. Outcomes were laboratory-confirmed influenza (LCI) and h...
Source: Vaccine - January 10, 2022 Category: Allergy & Immunology Authors: Damien Foo Mohinder Sarna Gavin Pereira Hannah C Moore Annette K Regan Source Type: research

Longitudinal, population-based cohort study of prenatal influenza vaccination and influenza infection in childhood
Vaccine. 2022 Jan 7:S0264-410X(21)01556-5. doi: 10.1016/j.vaccine.2021.11.084. Online ahead of print.ABSTRACTBACKGROUND: Influenza vaccination is recommended to protect mothers and their infants from influenza infection. Few studies have evaluated the health impacts of in utero exposure to influenza vaccine among children more than six months of age.METHODS: We used probabilistically linked administrative health records to establish a mother-child cohort to evaluate the risk of influenza and acute respiratory infections associated with maternal influenza vaccination. Outcomes were laboratory-confirmed influenza (LCI) and h...
Source: Vaccine - January 10, 2022 Category: Allergy & Immunology Authors: Damien Foo Mohinder Sarna Gavin Pereira Hannah C Moore Annette K Regan Source Type: research