Retraction notice to "Association of prior HPV vaccination with reduced preterm birth: A population based study" [Vaccine 36 (2018) 134-140].
Retraction notice to "Association of prior HPV vaccination with reduced preterm birth: A population based study" [Vaccine 36 (2018) 134-140]. Vaccine. 2020 Sep 29;38(42):6658 Authors: Lawton B, Howe AS, Turner N, Filoche S, Slatter T, Devenish C, Hung NA PMID: 32951764 [PubMed - in process] (Source: Vaccine)
Source: Vaccine - September 22, 2020 Category: Allergy & Immunology Authors: Lawton B, Howe AS, Turner N, Filoche S, Slatter T, Devenish C, Hung NA Tags: Vaccine Source Type: research

Characterization of rVSV ΔG-ZEBOV-GP glycoproteins using automated capillary western blotting.
Characterization of rVSVΔG-ZEBOV-GP glycoproteins using automated capillary western blotting. Vaccine. 2020 Sep 17;: Authors: Minsker K, Rustandi RR, Ha S, Loughney JW Abstract Ebolavirus (EBOV) entry to host cells requires membrane-associated glycoprotein (GP). A recombinant vesicular stomatitis virus vector carrying Zaire Ebola virus glycoprotein (rVSV-ZEBOV) was developed as a vaccine against ebolaviruses. The VSV glycoprotein gene was deleted (rVSVΔG) and ZEBOV glycoprotein (GP) was inserted into the deleted VSV glycoprotein open reading frame (ORF) resulting in a live, replication-com...
Source: Vaccine - September 17, 2020 Category: Allergy & Immunology Authors: Minsker K, Rustandi RR, Ha S, Loughney JW Tags: Vaccine Source Type: research

Maternal and paternal confidence in vaccine safety: Whose attitudes are predictive of children's vaccination?
Abstract Relatively little is known about the differential impact of maternal and paternal perceptions of vaccine safety on children's vaccination status in New Zealand. Using a sample of 68 couples from the New Zealand Attitudes and Values Study (NZAVS), the present study investigated the distinct influence of mothers' and fathers' confidence in the safety of childhood vaccinations following the national immunisation schedule on their reports of children's vaccination status. Actor-Partner Interdependence Modelling revealed that mothers', but not fathers', vaccine confidence predicted children's vaccination statu...
Source: Vaccine - September 17, 2020 Category: Allergy & Immunology Authors: Lee CHJ, Overall NC, Sibley CG Tags: Vaccine Source Type: research

Current status of virus-vectored vaccines against pathogens that affect poultry.
Abstract The most effective strategies for the control of disease in poultry are vaccination and biosecurity. Vaccines useful against pathogens affecting poultry must be safe, effective with a single dose, inexpensive, applicable by mass vaccination methods, and able to induce a protective immune response in the presence of maternal antibodies. Viral vector meet some of these characteristics and if the attenuated virus used as vector infects birds, the vaccine will have the advantage of being bivalent. Thus, viral vectors are currently a tool of choice for the development of new poultry vaccines. This review descr...
Source: Vaccine - September 17, 2020 Category: Allergy & Immunology Authors: Romanutti C, Keller L, Zanetti FA Tags: Vaccine Source Type: research

rOmpF and OMVs as efficient subunit vaccines against Salmonella enterica serovar Enteritidis infections in poultry farms.
In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry. PMID: 3...
Source: Vaccine - September 17, 2020 Category: Allergy & Immunology Authors: Li Q, Ren J, Xian H, Yin C, Yuan Y, Li Y, Ji R, Chu C, Qiao Z, Jiao X Tags: Vaccine Source Type: research

Yellow fever in children and adolescents previously immunized in Minas Gerais State, Brazil.
Conclusion - Prior YF vaccination may be associated with mild forms of the disease in children and adolescents. YF vaccination in the first years of life may be associated with poor vaccine response and high infection rates in this group as it fail to seroconvert a significant proportion of infants. PMID: 32950299 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 16, 2020 Category: Allergy & Immunology Authors: Diniz LMO, Romanelli RMC, Bentes AA, Silva NLCD, Soares Cruzeiro FR, Marcial TM, Ribeiro JGL Tags: Vaccine Source Type: research

The Health Belief Model in predicting healthcare workers' intention for influenza vaccine uptake in Jordan.
Abstract BACKGROUND: Theories of health behavior change are being inadequately adopted to understand the reasons behind low influenza vaccination rates among healthcare workers (HCWs). The Theory of Planned Behavior (TPB) is being used to predict intention-behavior relationship while the Health Belief Model (HBM) is being employed to predict actual behavior. The purpose of this study was to test a conceptual model based on the HBM's constructs to predict Jordanian HCWs' intentions for influenza vaccine uptake as an alternative to the TPB. METHOD: A cross-sectional questionnaire-based study was conducted in 20...
Source: Vaccine - September 16, 2020 Category: Allergy & Immunology Authors: Alhalaseh L, Fayoumi H, Khalil B Tags: Vaccine Source Type: research

The role of capsid in the flaviviral life cycle and perspectives for vaccine development.
Abstract The arthropod-borne flaviviruses cause a series of diseases in humans and pose a significant threat to global public health. In this review, we aimed to summarize the structure of the capsid protein (CP), its relevant multiple functions in the viral life cycle and innovative vaccines targeting CP. The flaviviral CP is the smallest structural protein and forms a homodimer by antiparallel α-helixes. Its primary function is to package the genomic RNA; however, both steps of assembly and dissociation of nucleocapsid complexes (NCs) have been obscure until now; in fact, flaviviral budding is NC-free, dem...
Source: Vaccine - September 16, 2020 Category: Allergy & Immunology Authors: He Y, Wang M, Chen S, Cheng A Tags: Vaccine Source Type: research

Corrigendum to "Seroprevalence and durability of rubella virus antibodies in a highly immunized population". [Vaccine 37 (2019) 3876-3882].
Corrigendum to "Seroprevalence and durability of rubella virus antibodies in a highly immunized population". [Vaccine 37 (2019) 3876-3882]. Vaccine. 2020 Sep 16;: Authors: Crooke SN, Haralambieva IH, Grill DE, Ovsyannikova IG, Kennedy RB, Poland GA PMID: 32950302 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 16, 2020 Category: Allergy & Immunology Authors: Crooke SN, Haralambieva IH, Grill DE, Ovsyannikova IG, Kennedy RB, Poland GA Tags: Vaccine Source Type: research

The role of National Immunization Technical Advisory Groups (NITAG) in strengthening health system governance: Lessons from three middle-income countries-Argentina, Jordan, and South Africa (2017-2018).
CONCLUSIONS: Systematically implementing governance approaches could improve processes, better tailor policies, and implementation. The long-term survival and resilience of NITAGs in these countries showed they play a significant role in strengthening governance. Lessons learned could be useful to those promoting country-driven evidence-informed decision-making. PMID: 32950303 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 16, 2020 Category: Allergy & Immunology Authors: Panero MS, Khuri-Bulos N, Biscayart C, Bonvehí P, Hayajneh W, Madhi SA Tags: Vaccine Source Type: research

Improving the quality and use of immunization and surveillance data: Summary report of the Working Group of the Strategic Advisory Group of Experts on Immunization.
Abstract Concerns about the quality and use of immunization and vaccine-preventable disease (VPD) surveillance data have been highlighted on the global agenda for over two decades. In August 2017, the Strategic Advisory Group of Experts (SAGE) established a Working Group (WG) onthe Quality and Use of Global Immunization and Surveillance Data to review the current status and evidence to make recommendations, which were presented to SAGE in October 2019. The WG synthesized evidence from landscape analyses, literature reviews, country case-studies, a data triangulation analysis, as well as surveys of experts. Data qu...
Source: Vaccine - September 16, 2020 Category: Allergy & Immunology Authors: Scobie HM, Edelstein M, Nicol E, Morice A, Rahimi N, MacDonald NE, Carolina Danovaro-Holliday M, Jawad J, SAGE Working Group on Immunization and Surveillance Data Quality and Use Tags: Vaccine Source Type: research

Correctly folded - but not necessarily functional - influenza virus neuraminidase is required to induce protective antibody responses in mice.
Abstract The influenza virus neuraminidase (NA) plays an integral role in the influenza virus life cycle through the release of virions from infected cells. NA-specific antibodies can impede virus replication by binding to the NA and blocking its enzymatic activity, providing significant protection from influenza-associated morbidity and mortality. NA included in current seasonal influenza virus vaccines exhibits low immunogenicity, potentially caused by compromised antigenic integrity during vaccine production. To determine how certain types of "stress" could influence the antigenicity of NA we performe...
Source: Vaccine - September 15, 2020 Category: Allergy & Immunology Authors: McMahon M, Strohmeier S, Rajendran M, Capuano C, Ellebedy AH, Wilson PC, Krammer F Tags: Vaccine Source Type: research

Evaluation of the immune responses against reduced doses of Brucella abortus S19 (calfhood) vaccine in water buffaloes (Bubalus bubalis), India.
CONCLUSION: Comparable immune responses were noticed with 1/10th reduced dose similar to standard dose. With this observation, decline of antibody titre will reduce the number of false positives and reduced dose of vaccine will facilitate larger vaccination coverage in the country. PMID: 32943264 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 14, 2020 Category: Allergy & Immunology Authors: Shome R, Kilari S, Sahare A, Kalleshamurthy T, Heballi Niranjanamurthy H, Ranjan Shome B, Hiremath J, Misri J, Rahman H Tags: Vaccine Source Type: research

Effective vaccine management through social behavior change communication: Exploring solutions using a participatory action research approach in the Solomon Islands.
Abstract Addressing vaccine management bottlenecks, including high vaccine wastage rates, has traditionally been addressed through health worker training and other didactic methods of technical assistance or support as required. It has been shown, though, that the high level of technical skills, expertise, and responsibility required in vaccine handling and management cannot be achieved by mere didactic learning. While gains have been made in vaccine management and handling with these approaches, there remain challenges of high vaccine wastage rates and poor vaccine management practices across the board. Interesti...
Source: Vaccine - September 14, 2020 Category: Allergy & Immunology Authors: Dadari I, Ssenyonjo J, Anga J Tags: Vaccine Source Type: research

Rate of preventative vaccine use and vaccine beliefs among a commercially insured population.
The objective of this study was to understand the factors associated with adherence, beliefs and behaviors of influenza, pneumococcal, and herpes zoster vaccines receipt among commercially insured adults. A cross-sectional survey of patients with medical and pharmacy benefits for a 24-month period between August 1, 2014 and July 31, 2016 who were eligible to receive at least one of three adult vaccines (influenza, pneumococcal, and herpes zoster) was completed. Patients were identified as eligible to receive a vaccine based on current guidelines from the CDC ACIP. Health plan members were identified from administrative cla...
Source: Vaccine - September 14, 2020 Category: Allergy & Immunology Authors: Bauer KA, Johnson K, Stephenson JJ, Visaria J, Chung H, York W, Kern DM, Puzniak LA Tags: Vaccine Source Type: research

Elucidating the difference in the kinetics of antibody titres of infants in Belgium and Vietnam.
Abstract Serological results obtained in a single laboratory from twin-studies on maternal immunisation, in Vietnam and Belgium offer the opportunity to compare antibody kinetics in infants before and after infant vaccination in the presence of vaccine-induced maternal antibodies. Nonlinear mixed-effects models (NLMMs) making use of a hypothesised dynamic evolution that captures the change in antibody titres over time, were employed to model anti-PT and anti-Prn antibody dynamics. Our proposed modelling approach provided useful insight into understanding the differences in the infants' antibody kinetics in both co...
Source: Vaccine - September 12, 2020 Category: Allergy & Immunology Authors: Tran TMP, Maertens K, Hoang HTT, Van Damme P, Leuridan E, Hens N Tags: Vaccine Source Type: research

Impact of the intestinal environment on the immune responses to vaccination.
Abstract Vaccination has contributed greatly to the control of infectious diseases; however, regional and individual differences are occasionally observed in the efficacy of vaccination. As one explanation for these differences, much attention has focused on the intestinal environment constructed by the interaction of diet and the gut microbiota. The intestinal environment has several physiological effects on the host immune system, both locally and systemically, and consequently influences the efficacy of vaccination. In this review, we discuss the impact of the gut microbiota and dietary nutrients on systemic an...
Source: Vaccine - September 12, 2020 Category: Allergy & Immunology Authors: Hosomi K, Kunisawa J Tags: Vaccine Source Type: research

Hemagglutinin from multiple divergent influenza A and B viruses bind to a distinct branched, sialylated poly-LacNAc glycan by surface plasmon resonance.
Abstract Influenza viruses initiate infection via specific interactions of hemagglutinin (HA) with host cell surface sialic acid-containing glycans. Antigenic drift has resulted in HA amino acid sequence changes that affect binding properties for sialic acids. Further, viral propagation in eggs and cell culture for vaccine production can yield variants with mutations that affect the conformation and affinity of HA for sialic acids. Therefore, influenza vaccine researchers and manufacturers need robust analytical methods to assess directly the ability of vaccine candidates to bind to their specific sialic acid liga...
Source: Vaccine - September 11, 2020 Category: Allergy & Immunology Authors: Bruce-Staskal PJ, Woods RM, Borisov OV, Massare MJ, Hahn TJ Tags: Vaccine Source Type: research

Combine two different dengue vaccines could efficiently target dengue-naive subjects. Comment to Macias A, Ruiz-Palacios G, Ramos-Castaneda J. Combine dengue vaccines to optimize effectiveness. Vaccine. 2020 Jun 26;38(31):4801-4804.
PMID: 32928589 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 11, 2020 Category: Allergy & Immunology Authors: Guy B Tags: Vaccine Source Type: research

Safety and efficacy of inactivated African horse sickness (AHS) vaccine formulated with different adjuvants.
Abstract African horse sickness virus (AHSV) is a virus species in the genus Orbivirus of the family Reoviridae causing African Horse Sickness (AHS) in equids with a mortality of about 95% in naïve horses. AHS causes serious losses in developing countries where horses play a central role in draft power and transportation. There are nine AHSV serotypes inducing no or low cross-neutralizing antibodies. AHSV is spread by biting Culicoides midges. AHS is endemic in sub-Saharan Africa, and a serious threat outside Africa, since Culicoides species in moderate climate conditions are spreading the closely related blu...
Source: Vaccine - September 10, 2020 Category: Allergy & Immunology Authors: van Rijn PA, Maris-Veldhuis MA, Grobler M, Wright IM, Erasmus BJ, Maartens LH, Potgieter CA Tags: Vaccine Source Type: research

Brand-specific rates of pertussis disease among Wisconsin children given 1-4 doses of pertussis Vaccine, 2010-2014.
Abstract BACKGROUND: Acellular pertussis vaccines were initially licensed based on placebo-controlled efficacy trials, but such trials are no longer ethical. The effectiveness of current pertussis vaccines among properly vaccinated children
Source: Vaccine - September 10, 2020 Category: Allergy & Immunology Authors: Conway JH, Davis JP, Eickhoff JC, Pool V, Greenberg DP, Decker MD Tags: Vaccine Source Type: research

Recurrent injection site reactions to vaccines: Two clinical patterns of presentation.
We describe a case series of recurrent injection site reactions in 8 children undergoing vaccines of the regional immunization schedule, which required specialized evaluation and advice for subsequent vaccinations. Two clinical patterns of reactions were observed. Four children manifested recurrent wheal and erythema with pruritus at vaccine injection site for up to 7 months; the remaining children showed an itching plaque or nodule at injection site, that lasted several months after vaccination with exacerbations of pruritus and erythema. Hypersensitivity to aluminium salts was demonstrated in the second group. The f...
Source: Vaccine - September 9, 2020 Category: Allergy & Immunology Authors: Zanoni G, Migliorini M, Gallo T, Guidolin L, Schena D Tags: Vaccine Source Type: research

Vaccine decision-making among parents of children on Medicaid with and without autism spectrum disorder.
CONCLUSION: Parental concerns about vaccines, the parent-provider relationship, and vaccine risk perception all contribute to vaccine decision-making among parents of children with and without ASD. However, providers may find it especially difficult to manage parental misconceptions about vaccines and developmental disabilities. Future studies can identify alternative communication techniques and determine what mechanisms may be more effective in encouraging vaccine acceptance among parents of children with ASD. PMID: 32917415 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 8, 2020 Category: Allergy & Immunology Authors: Holroyd TA, Sauer MA, Limaye RJ Tags: Vaccine Source Type: research

Immunity to Hepatitis-A virus: A nationwide population-based seroprevalence study from Iran.
CONCLUSIONS: This study showed that Iran is among HAV low endemic countries and vaccination against HAV is recommended only in the high-risk population, including patients with chronic liver diseases, patients with coagulopathy, travelers to the high endemic areas, and homosexuals. Establishment of national HAV surveillance system, concerning of health system about the occurrence of the HAV outbreaks, implementation of harm reduction strategies, improving economic indices and sanitation and access to the safe water in the deprived regions is recommended. PMID: 32917416 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 8, 2020 Category: Allergy & Immunology Authors: Lankarani KB, Honarvar B, Molavi Vardanjani H, Kharmandar A, Gouya MM, Zahraei SM, Baneshi MR, Ali-Akbarpour M, Kazemi M, Seif M, Fard SAZ, Emami A Tags: Vaccine Source Type: research

Ten year public health impact of 13-valent pneumococcal conjugate vaccination in infants: A modelling analysis.
Abstract Pneumococcal disease is a substantial contributor to illness and death in young children globally. The introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in 2000 had a significant impact in preventing pneumococcal disease in both vaccinated children and unvaccinated individuals (through herd effect). A higher valent PCV13 replaced PCV7 in late 2009. This analysis was undertaken to assess how many cases and deaths have been averted over the last decade since PCV13 introduction. A model estimated the number of infants vaccinated annually with PCV13, as well as the number of cases and deaths of i...
Source: Vaccine - September 7, 2020 Category: Allergy & Immunology Authors: Chapman R, Sutton K, Dillon-Murphy D, Patel S, Hilton B, Farkouh R, Wasserman M Tags: Vaccine Source Type: research

Caregiver and service provider vaccine confidence following the Changchun Changsheng vaccine incident in China: A cross-sectional mixed methods study.
CONCLUSION: After an initial decline, vaccine confidence recovered to pre-incident levels six months after the CCVI. However, some caregivers moved from the higher to the lower end of the vaccine confidence spectrum, pointing to the need to promote the acceptance of vaccination especially given the need for new vaccines to control the coronavirus epidemic. PMID: 32912643 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 7, 2020 Category: Allergy & Immunology Authors: Tu S, Sun FY, Chantler T, Zhang X, Jit M, Han K, Rodewald L, Du F, Yu H, Hou Z, Larson H Tags: Vaccine Source Type: research

Immune response at 12-23  months following a single dose of Vero cell culture-derived Japanese encephalitis (JE) vaccine in adults previously vaccinated with mouse brain-derived JE vaccine.
CONCLUSIONS: One JE-VC dose in previously JE-MB-vaccinated military personnel provides good protection for at least 1-2 years. The benefits of administration of a single JE-VC dose in previously JE-MB-vaccinated adults include a shorter time to completion of re-vaccination before travel, a decrease in the risk of adverse events, and reduced costs. PMID: 32907756 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 6, 2020 Category: Allergy & Immunology Authors: Krow-Lucal ER, Laven J, Perry L, Biggerstaff BJ, Johnson BW, Hollis E, Fischer M, Woolpert T, Hills SL Tags: Vaccine Source Type: research

Live attenuated Salmonella enterica serovar Choleraesuis vector delivering a conserved surface protein enolase induces high and broad protection against Streptococcus suis serotypes 2, 7, and 9 in mice.
Abstract Streptococcus suis, a major zoonotic pathogen in swine, can be classified into 35 serotypes. However, no universal vaccine against the multiple serotypes of S. suis is available, though some studies have shown homologous protection. Hence, developing an effective universal vaccine to protect pigs against multiple S. suis serotypes is necessary, or at the very least, to protect pigs against diseases caused by the dominant pathogenic serotypes. Enolase, a highly conserved surface protein, is present in all of the described S. suis serotypes. rSC0016 is an improved recombinant attenuated S. Choleraesuis vacc...
Source: Vaccine - September 6, 2020 Category: Allergy & Immunology Authors: Li Q, Lv Y, Li YA, Du Y, Guo W, Chu D, Wang X, Wang S, Shi H Tags: Vaccine Source Type: research

The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of viral vector vaccines.
r@taskforce.org Abstract Many of the vaccines under development for COVID-19 involve the use of viral vectors. The Brighton Collaboration Benefit-Risk Assessment of Vaccines by Technology (BRAVATO, formerly the Viral Vector Vaccine Safety Working Group, V3SWG) working group has prepared a standardized template to describe the key considerations for the benefit-risk assessment of viral vector vaccines. This will facilitate key stakeholders to anticipate potential safety issues and interpret or assess safety data. This would also help improve communication and public acceptance of licensed viral vector vaccines. ...
Source: Vaccine - September 6, 2020 Category: Allergy & Immunology Authors: Condit RC, Kim D, Robertson JS, Excler JL, Gurwith M, Monath TP, Pavlakis G, Fast PE, Smith J, Smith ER, Chen RT, Kochhar S, Brighton Collaboration Benefit-Risk Assessment of Vaccines by Technology (BRAVATO) Working Group. Electronic address: bc-coordinat Tags: Vaccine Source Type: research

Temporal analysis of the bovine lymph node transcriptome during cattle tick (Rhipicephalus microplus) infestation.
In this study, gene expression patterns were compared within the lymph nodes of three cattle breeds at different life stages of the cattle tick, Rhipicephalus microplus. For Bonsmara (5/8Bos taurus indicus × 3/8B. t. taurus) cattle specifically, some 183 genes were found to be differentially expressed within the lymph nodes during larval and adult tick feeding, relative to uninfested cattle. Overall, the data provides evidence for a transcriptional regulatory network that is activated during immature tick infestation, but is down-regulated towards basal transcriptional levels when adult ticks are feeding. S...
Source: Vaccine - September 5, 2020 Category: Allergy & Immunology Authors: Robbertse L, Richards SA, Stutzer C, Olivier NA, Leisewitz AL, Crafford JE, Maritz-Olivier C Tags: Vaccine Source Type: research

Laboratory confirmation of congenital rubella syndrome in South Korea in 2017: A genomic epidemiological investigation.
PMID: 32900541 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 5, 2020 Category: Allergy & Immunology Authors: Wang JS, Lee HM, Kim SJ, Kim JS, Kang C, Won Jung C, In HK, Seo DH, Lee DH, Chung YS Tags: Vaccine Source Type: research

A bivalent HCV peptide vaccine elicits pan-genotypic neutralizing antibodies in mice.
Abstract Vaccine development for antigenically variable pathogens has faltered because extreme genetic diversity precludes induction of broadly neutralizing antibodies (nAB) with classical vaccines. Here, using the most variable epitope of any known human pathogen (HVR1 of HCV), we describe a novel approach capable of eliciting broadly neutralizing antibodies targeting highly variable epitopes. Our proof-of-concept vaccine elicited pan-genotypic nAB against HCV variants differing from the immunogen sequences by more than 70% at the amino acid level. These findings suggest broadly nAB to highly variable pathogens c...
Source: Vaccine - September 5, 2020 Category: Allergy & Immunology Authors: Mosa AI, Urbanowicz RA, AbouHaidar MG, Tavis JE, Ball JK, Feld JJ Tags: Vaccine Source Type: research

Perceptions of French healthcare students of vaccines and the impact of conducting an intervention in health promotion.
CONCLUSIONS: A portion of French healthcare students show traits of vaccine hesitancy, with significant differences depending on the courses attended. Programs of health promotion, such as the French SSES program, which includes a primary prevention intervention conducted by multidisciplinary groups of students, may improve the global confidence of healthcare students concerning vaccination. PMID: 32896467 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 4, 2020 Category: Allergy & Immunology Authors: Lepiller Q, Bouiller K, Slekovec C, Millot D, Mazué N, Pourchet V, Balice R, Garrien-Maire F, Simon E, Wintenberger V, Guillaume A, Monaton MF, Van Eis B, Bertrand X, Bennabi D, Moulin T, Anxionnat R, Nerich V Tags: Vaccine Source Type: research

Serum IgG2 levels predict long-term protection following pneumococcal vaccination in systemic lupus erythematosus (SLE).
Abstract Systemic lupus erythematosus (SLE) patients are at risk for pneumococcal infection. Twenty-one consecutive SLE patients (40[25-75] years) received the sequential PCV13/PPSV23 vaccine and factors associated with long-term protection were analyzed. Immune protection, defined by an antigen-specific IgG concentration ≥1.3 µg/mL for at least 70% of 7 pneumococcal serotypes was assessed at baseline, 2, 6, 12 and 36 months defining long-term protection. Only 10 patients showed pneumococcal immune protection 36 months after vaccination. Eleven (52.4%) patients had no long-term protection w...
Source: Vaccine - September 4, 2020 Category: Allergy & Immunology Authors: Gerard AL, Goulenok T, Bahuaud M, Francois C, Aucouturier P, Moins-Teisserenc H, Batteux F, Papo T, Sacre K Tags: Vaccine Source Type: research

Knowledge and attitudes towards influenza and influenza vaccination among pregnant women in Kenya.
CONCLUSION: Approximately one third of pregnant women interviewed had never heard of influenza. Willingness to receive influenza vaccine was high among women who had heard about influenza. If the Kenyan government recommends influenza vaccine for pregnant women, mitigation of safety concerns and education on the benefits of vaccination could be the most effective strategies to improve vaccine acceptance. PMID: 32893035 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 3, 2020 Category: Allergy & Immunology Authors: Otieno NA, Nyawanda B, Otiato F, Adero M, Wairimu WN, Atito R, Wilson AD, Gonzalez-Casanova I, Malik FA, Verani JR, Widdowson MA, Omer SB, Chaves SS Tags: Vaccine Source Type: research

Pregnant women's perceptions of risks and benefits when considering participation in vaccine trials.
CONCLUSION: Some pregnant women are accepting of participation in vaccine research during infectious disease outbreaks. Incorporating their priorities into trial design may facilitate their participation and generation of evidence for this important population. PMID: 32893036 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 3, 2020 Category: Allergy & Immunology Authors: Jaffe E, Lyerly AD, Goldfarb IT Tags: Vaccine Source Type: research

Decision making process, programmatic and logistic impact of the transition from a single-dose vial to a multi-dose vial of the 13-valent pneumococcal vaccine in Benin.
CONCLUSION: Benin's experience in transition to an MDV presentation of PCV13 reveals the need for better preparation and planning. PMID: 32893037 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 3, 2020 Category: Allergy & Immunology Authors: Kaucley L, Essoh TA, Ilboudo GP, Abdoulaye Alfa D, Dicko M, Houngnihin RA, Satoulou-Maleyo A, Bété FH, Agossadou DC Tags: Vaccine Source Type: research

Increasing vaccination coverage: The school entry vaccination record check program in Guizhou Province China, 2003-2018.
CONCLUSIONS: Checking vaccination record at kindergartens and primary schools and providing necessary catch-up vaccination was associated with increased coverage of measles and other vaccines, lower incidence of measles, and an apparent end to school-based measles outbreaks. Guizhou's experience of checking vaccination records at school enrollment led to implementation of this strategy in other provinces. In 2019, the kindergarten and school entry vaccination record check program was incorporated into China's national vaccine law. PMID: 32891472 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 2, 2020 Category: Allergy & Immunology Authors: Zuo S, Zhang D, Mu Q, Dai L, Du W, Xu F, Feng J, Heffelfinger JD Tags: Vaccine Source Type: research

Changes in parents' decisions pertaining to vaccination of their children after the Changchun Changsheng vaccine scandal in Guangzhou, China.
Abstract A series of scandals involving the rabies vaccine and the diphtheria, tetanus, and pertussis combined vaccine (DTP) were reported in July 2018, in China. Our goal was to assess the effects of the vaccine scandal on parents' attitudes and decisions regarding vaccination. A cross-sectional study was conducted by contacting kindergarteners' parents through an online questionnaire from March 1 to 8, 2019. In total, 14,300 valid questionnaire responses were received, and 92.53% of respondents were aware of the recent vaccine scandal. Among parents who were aware of the vaccine scandal, 13.62% preferred that th...
Source: Vaccine - September 2, 2020 Category: Allergy & Immunology Authors: He Q, Wang H, Ma Y, Wang Z, Zhang Z, Li T, Yang Z Tags: Vaccine Source Type: research

Endpoint and epitope-specific antibody responses as correlates of vaccine-mediated protection of mice against ricin toxin.
In this report we describe a multivariate model that combines pre-challenge serum antibody endpoint titers (EPT) and values derived from an epitope profiling immune-competition capture (EPICC) assay as a predictor in mice of vaccine-mediated immunity against ricin toxin (RT), a Category B biothreat. EPICC is a modified competition ELISA in which serum samples from vaccinated mice were assessed for their ability to inhibit the capture of soluble, biotinylated (b)-RT by a panel of immobilized monoclonal antibodies (mAbs) directed against four immunodominant toxin-neutralizing regions on the enzymatic A chain (RTA) of RT. In ...
Source: Vaccine - September 2, 2020 Category: Allergy & Immunology Authors: Slyke GV, Ehrbar DJ, Doering J, Yates JL, Vitetta ES, Donini O, Mantis NJ Tags: Vaccine Source Type: research

The continuum of influenza vaccine hesitancy among nursing professionals in Hong Kong.
CONCLUSION: With more than half of the nurses in Hong Kong having moderate or higher level of influenza vaccine hesitancy, interventions customised to the needs of nurses as reflected from the characteristics of clusters along the vaccine hesitancy continuum could form an important strategy for improving vaccination uptake. PMID: 32891475 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 2, 2020 Category: Allergy & Immunology Authors: Lau LHW, Lee SS, Wong NS Tags: Vaccine Source Type: research

County-level correlates of missed opportunities for HPV vaccination in Indiana: An environmental scan.
CONCLUSIONS: We found wide variability in missed opportunities across counties, which were associated with population density and county-level participation in other health-related behaviors. SOURCES OF SUPPORT: This study was supported by the National Cancer Institute under Award Number P30 CA082709-18S4. PMID: 32891476 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 2, 2020 Category: Allergy & Immunology Authors: Enujioke SC, Shedd-Steele R, Daggy J, Burney H, Robertson L, Head K, Zimet G Tags: Vaccine Source Type: research

Adjuvants for swine vaccines: Mechanisms of actions and adjuvant effects.
Abstract This review deals with mechanisms of actions (MOA) and adjuvant effects of various types of adjuvants for swine vaccines. A number of different types of adjuvants have been tested with swine vaccines, including oil emulsion, particulate antigen (Ag) carrier, cytokines, pathogen-associated molecular patterns and immune ligands, saponins, and bacterial cells and toxins. In addition, there are a number of chemicals and natural products that possess adjuvant activities when tested with swine vaccines, and are grouped as miscellaneous in this review. The MOA of adjuvants can be generally divided into two categ...
Source: Vaccine - September 1, 2020 Category: Allergy & Immunology Authors: Charerntantanakul W Tags: Vaccine Source Type: research

Safety and efficacy of a novel inactivated trivalent Salmonella enterica vaccine in chickens.
Abstract Food poisoning in humans caused by Salmonella enterica remains a significant global public health concern, with the majority of infections associated with the consumption of contaminated eggs or poultry products. The safety and efficacy of a novel inactivated trivalent Salmonella enterica vaccine containing in addition to Salmonella serovars Enteritidis (O:9, serogroup D) and Typhimurium (O:4, serogroup B) also serovar Infantis (O:7, serogroup C1) formulated with an aluminium hydroxide-gel adjuvant was evaluated under field conditions. A total of 10,229 broiler breeder pullets, housed under commercial con...
Source: Vaccine - September 1, 2020 Category: Allergy & Immunology Authors: Crouch CF, Nell T, Reijnders M, Donkers T, Pugh C, Patel A, Davis P, van Hulten MCW, de Vries SPW Tags: Vaccine Source Type: research

Levels of antibodies specific to diphtheria toxoid, tetanus toxoid, and Haemophilus influenzae type b in healthy children born to Tdap-vaccinated mothers.
CONCLUSIONS: Vaccination with a TT-containing and/or the Tdap vaccine during pregnancy did not compromise the seroprotection rate achieved following primary and booster immunization in individuals receiving either the pentavalent or hexavalent vaccine. PMID: 32888740 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 1, 2020 Category: Allergy & Immunology Authors: Wanlapakorn N, Maertens K, Thongmee T, Srimuan D, Thatsanathorn T, Van Damme P, Leuridan E, Poovorawan Y Tags: Vaccine Source Type: research

Systematic review of Group B Streptococcal capsular types, sequence types and surface proteins as potential vaccine candidates.
DISCUSSION: A hexavalent vaccine (serotypes Ia, Ib, II, III, IV and V) might provide comprehensive cover for all at-risk populations. Surveillance of circulating, disease-causing target proteins is useful to inform vaccines not targeting capsular polysaccharide. Addressing data gaps especially by world region and some at-risk populations (notably stillbirths) is fundamental to evidence-based decision-making during vaccine design. PMID: 32888741 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 1, 2020 Category: Allergy & Immunology Authors: Bianchi-Jassir F, Paul P, To KN, Carreras-Abad C, Seale AC, Jauneikaite E, Madhi SA, Russell NJ, Hall J, Madrid L, Bassat Q, Kwatra G, Le Doare K, Lawn JE Tags: Vaccine Source Type: research

Parent reported outcomes to measure satisfaction, acceptability, and daily life impact after vaccination with whole-cell and acellular pertussis vaccine in Chile.
CONCLUSIONS: Overall, satisfaction, intention for future vaccination, and lower impact on the family daily routine were significantly better in the group receiving the hexavalent vaccine. We also found that health care providers' recommendations to vaccinate and participants' access to health services were important factors favoring immunization. PMID: 32888742 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - September 1, 2020 Category: Allergy & Immunology Authors: O'Ryan M, Calvo AE, Espinoza M, Vega N, Lagomarcino AJ, López Castillo H, Puentes E, Macina D Tags: Vaccine Source Type: research

Safety and immunogenicity of an investigational maternal trivalent group B streptococcus vaccine in pregnant women and their infants: Results from a randomized placebo-controlled phase II trial.
CONCLUSIONS: Maternal immunization with the trivalent GBS vaccine in US women had a favorable safety profile, elicited antibodies that were transplacentally transferred and persisted in infants for a minimum of 3 months. CLINICAL TRIAL REGISTRATION: Clinicaltrials.gov, NCT02046148. PMID: 32883555 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - August 31, 2020 Category: Allergy & Immunology Authors: Swamy GK, Metz TD, Edwards KM, Soper DE, Beigi RH, Campbell JD, Grassano L, Buffi G, Dreisbach A, Margarit I, Karsten A, Henry O, Lattanzi M, Bebia Z Tags: Vaccine Source Type: research

Immunoprophylaxis pharmacotherapy against canine leishmaniosis: A systematic review and meta-analysis on the efficacy of vaccines approved in European Union.
Abstract Leishmania (L.) infantum is a vector-borne parasite currently endemic in several Southern countries of European Union (EU), and dogs represent the main reservoir and hosts. Data from clinical trials are inconsistent with respect to the efficacy of vaccination against L. infantum infection. Therefore, a quantitative synthesis via pairwise meta-analysis was performed in agreement with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) to increase the strength of evidence and assess the real efficacy profile of vaccines against L. infantum currently approved in EU. Dat...
Source: Vaccine - August 31, 2020 Category: Allergy & Immunology Authors: Calzetta L, Pistocchini E, Ritondo BL, Roncada P, Palma E, di Cave D, Mattei M, Britti D Tags: Vaccine Source Type: research

Efficacy of an intramuscular bivalent norovirus GI.1/GII.4 virus-like particle vaccine candidate in healthy US adults.
Abstract BACKGROUND: We performed this first-in-human efficacy trial of Takeda's bivalent norovirus vaccine candidate (TAK-214) against moderate or severe acute gastroenteritis (AGE) in healthy adults. METHODS: This double-blind, randomized, placebo-controlled phase 2b trial was conducted over two winter seasons in 18-49 year-old US Navy recruits. Participants were randomized (1:1) to receive intramuscular injections of saline placebo (N = 2,357) or TAK-214 [15 μg GI.1 and 50 μg GII.4c VLPs, 0.5 mg Al(OH)3] (N = 2,355), and monitored for 45 days post-vaccinat...
Source: Vaccine - August 30, 2020 Category: Allergy & Immunology Authors: Sherwood J, Mendelman PM, Lloyd E, Liu M, Boslego J, Borkowski A, Jackson A, Faix D, US Navy study team Tags: Vaccine Source Type: research