Barriers and facilitators of implementing a collaborative HPV vaccine program in an incarcerated population: A case study.
CONCLUSION: Finding ways to leverage leadership and staff buy-in and address specific barriers of constrained resources and divergent culture and priorities merits close attention, since partnerships between jails and local HD have potential to increase HPV vaccination rates in an overlooked population and advance public health. PMID: 32046888 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 8, 2020 Category: Allergy & Immunology Authors: Emerson A, Allison M, Kelly PJ, Ramaswamy M Tags: Vaccine Source Type: research

Pharmacists' impact on older adults' access to vaccines in the United States.
CONCLUSION: Vaccinations are important in protecting and maintaining the health of older adults. Pharmacists improved access to vaccinations and served many roles in the vaccination process. Future research should explore how pharmacists impact access to vaccines beyond vaccination rates, especially regarding the financial impact on patients. PMID: 32046889 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 8, 2020 Category: Allergy & Immunology Authors: Beal JL, Kadakia NN, Reed JB, Illingworth Plake KS Tags: Vaccine Source Type: research

Evaluation of the stability of measles vaccine out of the cold chain under extended controlled temperature conditions.
Abstract Measles outbreaks occur periodically in remote and difficult to reach areas in countries such as the Democratic Republic of Congo. The possibility to keep measles vaccines at temperatures outside the cold chain for a limited period prior to administration would be an advantage for organizations such as Médecins Sans Frontières, which repeatedly respond to measles outbreaks in difficult contexts. Using stability data at 37 °C and 40 °C provided by Serum Institute of India Private Limited we applied the product release model for Extended Controlled Temperature Conditions (ECT...
Source: Vaccine - February 8, 2020 Category: Allergy & Immunology Authors: Juan-Giner A, Alsalhani A, Panunzi I, Lambert V, Van Herp M, Gairola S Tags: Vaccine Source Type: research

Assessment of pre-specified adverse events following varicella vaccine: A population-based self-controlled risk interval study.
CONCLUSIONS: We detected a small risk of incidental pneumonia associated with varicella vaccine in the 6th week after immunization. There was no increase in the risk of other pre-specified adverse events. PMID: 32046891 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 8, 2020 Category: Allergy & Immunology Authors: Liu CH, Yeh YC, Huang WT, Chie WC, Chan KA Tags: Vaccine Source Type: research

Influenza vaccination rate and its association with chronic diseases in China: Results of a national cross-sectional study.
Abstract INTRODUCTION: Influenza vaccination is the most effective way to prevent influenza. Few studies on its rate were reported throughout China and for populations with chronic diseases. An estimation of the rates in China was accomplished. METHODS: All data were from a national cross-sectional survey of a sample representing the population aged 40 years or older in mainland China in 2014-15. A total of 74,484 individuals with complete self-reported influenza vaccination status were analyzed in 2018-19. RESULTS: The overall influenza vaccination rate was 2.4% (95% CI 1.4-3.3) with 1.7% (95% CI 1...
Source: Vaccine - February 8, 2020 Category: Allergy & Immunology Authors: Fan J, Cong S, Wang N, Bao H, Wang B, Feng Y, Lv X, Zhang Y, Zha Z, Yu L, Yang T, Wang L, Fang L Tags: Vaccine Source Type: research

A novel amino acid site closely associated with the neurovirulence of live, attenuated Japanese encephalitis vaccine (SA14-14-2 strain).
In this study, we introduced a single mutation at nt1708 (G → A) in the full-length cDNA clone of SA14-14-2, replacing a Gly with Glu at amino acid residue 244 of the E glycoprotein, and successfully constructed the mutant virus (JEV E244). JEV E244 exhibited a similar plaque morphology and growth characteristics to JEV SA14-14-2 in cell culture. However, it had lethal neurovirulence in mice and could enter the brain following intraperitoneal inoculation. Moreover, the virulence of JEV E244 in the context of vaccine in mice is significantly different from that of the JEV E244 alone. These results suggested t...
Source: Vaccine - February 7, 2020 Category: Allergy & Immunology Authors: Yang H, Fan F, Liu L, Liu J, Sun Y, Xie A, Shi X, Liu L, Yu Y, Li Y, Ge Y, Zeng X, Yang H Tags: Vaccine Source Type: research

Comparison of influenza-specific neutralizing antibody titers determined using different assay readouts and hemagglutination inhibition titers: good correlation but poor agreement.
Abstract Determination of influenza-specific antibody titers is commonly done using the hemagglutination inhibition assay (HAI) and the viral microneutralization assay (MN). Both assays are characterized by high intra- and inter-laboratory variability. The HAI assay offers little opportunity for standardization. For the MN assay, variability might be due to the use of different assay protocols employing different readouts. We therefore aimed at investigating which of the MN assay readout methods currently in use would be the most suitable choice for a standardized MN assay that could serve as a substitute for the ...
Source: Vaccine - February 7, 2020 Category: Allergy & Immunology Authors: Sicca F, Martinuzzi D, Montomoli E, Huckriede A Tags: Vaccine Source Type: research

Bacteriophage Q β virus-like particles displaying Chikungunya virus B-cell epitopes elicit high-titer E2 protein antibodies but fail to neutralize a Thailand strain of Chikungunya virus.
Bacteriophage Qβ virus-like particles displaying Chikungunya virus B-cell epitopes elicit high-titer E2 protein antibodies but fail to neutralize a Thailand strain of Chikungunya virus. Vaccine. 2020 Feb 07;: Authors: Basu R, Zhai L, Rosso B, Tumban E Abstract Chikungunya virus (CHIKV) is a mosquito-borne virus associated with arthritis and musculoskeletal pains. More than 2.9 million people worldwide have been infected with the virus within the last 1.5 decades; currently, there are no approved vaccines to protect against CHIKV infection. To assess the potential of using CHIKV peptides as vaccin...
Source: Vaccine - February 7, 2020 Category: Allergy & Immunology Authors: Basu R, Zhai L, Rosso B, Tumban E Tags: Vaccine Source Type: research

Protective efficacy of recombinant bacterin vaccine against botulism in cattle.
In this study, the recombinant protein vaccine was produced using an Escherichia coli cell-based system. The formaldehyde-inactivated E. coli is able to induce 7.45 ± 1.77 and 6.6 ± 1.28 IU/mL neutralizing mean titers against BoNTs C and D in cattle, respectively, determined by mouse neutralization bioassay, and was deemed protective by the Brazilian legislation. Moreover, when the levels of anti-BoNT/C and D were compared with those achieved by the recombinant purified vaccines, no significant statistical difference was observed. Cattle vaccinated with the commercial vaccine develope...
Source: Vaccine - February 6, 2020 Category: Allergy & Immunology Authors: Moreira C, Ferreira MRA, Finger PF, Magalhães CG, Cunha CEP, Rodrigues RR, Otaka DY, Galvão CC, Salvarani FM, Moreira ÂN, Conceição FR Tags: Vaccine Source Type: research

Shades of gray in vaccination decisions - Understanding community pharmacists' perspectives of, and experiences with, influenza vaccine hesitancy in Ontario, Canada.
CONCLUSION: While pharmacists hold the potential to effectively address influenza VH within their communities, future interventions must aim to break the loop of passive patient engagement and enable proactive pharmacist-patient interactions on influenza vaccinations in this setting. PMID: 32037223 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 6, 2020 Category: Allergy & Immunology Authors: Pullagura GR, Violette R, Houle SKD, Waite NM Tags: Vaccine Source Type: research

To attend or not to attend? The effect of school-immunization exemption policies on enrollment rates for prekindergarten, kindergarten and elementary aged youth.
Abstract There is no national immunization policy in the United States, and the strictness of regulations allowing vaccine exemption for school attendance varies greatly by state. Despite substantial evidence on the safety and health benefits of immunization, there has been a recent upsurge in skepticism amongst parents regarding vaccine safety and efficacy for their children. To measure the effect of strictness of immunization policy on enrollment rates for school aged children, we utilize fixed effects regression. We construct a panel of data on county level enrollment rate and county characteristics from the Am...
Source: Vaccine - February 6, 2020 Category: Allergy & Immunology Authors: Zier ER, Bradford WD Tags: Vaccine Source Type: research

Lower immunity to poliomyelitis viruses in Australian young adults not eligible for inactivated polio vaccine.
Abstract There are limited long-term data on seroprevalence of neutralising antibody (nAb) to the three poliovirus serotypes following the switch from oral polio vaccine (OPV) to inactivated polio vaccine (IPV). In Australia, combination vaccines containing IPV replaced OPV in late 2005. Using serum and plasma specimens collected during 2012 and 2013, we compared prevalence of nAb to poliovirus type 1 (PV1), type 2 (PV2) and type 3 (PV3) in birth cohorts with differing IPV and OPV eligibility from an Australian population-based sample. In the total sample of 1673 persons aged 12 months to 99 years, 85% h...
Source: Vaccine - February 6, 2020 Category: Allergy & Immunology Authors: Hendry AJ, Beard FH, Dey A, Quinn H, Hueston L, Dwyer DE, McIntyre PB Tags: Vaccine Source Type: research

Deletion of major porins from meningococcal outer membrane vesicle vaccines enhances reactivity against heterologous serogroup B Neisseria meningitidis strains.
In this study, dOMV vaccines deficient in major OMPs, including PorA, PorB, and RmpM were isolated and used to immunize rabbits and mice. Serum samples were obtained from each animal and tested for antibody responses against five MenB strains. Immunization with wild type dOMVs elicited antibodies to major antigens including PorA, PorB, RmpM, and lipooligosaccharide (LOS), and demonstrated limited bactericidal activity against heterologous strains. In contrast, OMP-deficient dOMV vaccines elicited broadly cross-reactive bactericidal antibodies, with PorA/PorB-dual deficient dOMVs inducing antibodies exhibiting the greatest ...
Source: Vaccine - February 6, 2020 Category: Allergy & Immunology Authors: Matthias KA, Reveille A, Connolly KL, Jerse AE, Gao YS, Bash MC Tags: Vaccine Source Type: research

Emergent measles-containing vaccination recommendation for aged 6-11  months and detection of vaccine-associated measles during a large measles outbreak in Okinawa, Japan, in 2018.
Emergent measles-containing vaccination recommendation for aged 6-11 months and detection of vaccine-associated measles during a large measles outbreak in Okinawa, Japan, in 2018. Vaccine. 2020 Feb 06;: Authors: Kuba Y, Kyan H, Iha Y, Kato T, Oyama M, Miyahira M, Kakita T, Takara T, Yamauchi M, Kamiya H, Sunagawa T, Kawakami Y, Nidaira M, Kudaka J, Yamakawa M, Itokazu T, Itokazu K Abstract Okinawa Prefecture, Japan, experienced a large measles outbreak from March to May 2018. During this outbreak, there were 99 laboratory-confirmed cases and 14 vaccine-associated measles cases. In addition to the...
Source: Vaccine - February 6, 2020 Category: Allergy & Immunology Authors: Kuba Y, Kyan H, Iha Y, Kato T, Oyama M, Miyahira M, Kakita T, Takara T, Yamauchi M, Kamiya H, Sunagawa T, Kawakami Y, Nidaira M, Kudaka J, Yamakawa M, Itokazu T, Itokazu K Tags: Vaccine Source Type: research

Impact of HIV status and vaccination schedule on bacterial nasopharyngeal carriage following infant immunisation with the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in South Africa.
CONCLUSIONS: HIV infection or exposure did not seem to alter the effect of PHiD-CV on pneumococcal NPC in children during their first 2 years of life. NPC prevalence of vaccine-type pneumococci following vaccination series tended to be lower in children who had received a booster dose in comparison to those who had not. PMID: 32035706 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 5, 2020 Category: Allergy & Immunology Authors: Madhi SA, Moreira M, Koen A, van Niekerk N, de Gouveia L, Jose L, Cutland CL, François N, Schoonbroodt S, Ruiz-Guiñazú J, Yarzabal JP, Borys D, Schuerman L Tags: Vaccine Source Type: research

Measuring equitable delivery of vaccines.
PMID: 32035707 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 5, 2020 Category: Allergy & Immunology Authors: Durrheim DN Tags: Vaccine Source Type: research

Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults.
CONCLUSIONS: In this cohort of community-dwelling older adults, the QIV was at least as good as the adjuvanted TIV in the induction of ADCC and HAI responses. Further studies on how these antibody responses translate to efficacy in preventing influenza infections are warranted. PMID: 32035709 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 5, 2020 Category: Allergy & Immunology Authors: Vanderven HA, Barr I, Reynaldi A, Wheatley AK, Wines BD, Davenport MP, Hogarth PM, Kent SJ Tags: Vaccine Source Type: research

An assessment of parents' childhood immunization beliefs, intentions, and behaviors using a smartphone panel.
CONCLUSIONS: This survey provided insights into beliefs and behaviors of parents regarding childhood vaccination. It found evidence of differences in beliefs, particularly related to delaying or declining recommended childhood vaccinations. The survey was conducted in a few days and at lower cost than traditional methods. This serves as a model for health agencies where rapid results or inexpensive approaches are needed. PMID: 32035710 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 5, 2020 Category: Allergy & Immunology Authors: Boyle J, Berman L, Nowak GJ, Iachan R, Middleton D, Deng Y Tags: Vaccine Source Type: research

Improving vaccine policy making: A dose of reality.
PMID: 32033846 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 5, 2020 Category: Allergy & Immunology Authors: Reiss DR, Offit PA Tags: Vaccine Source Type: research

Influenza vaccine effectiveness against hospitalization with laboratory-confirmed influenza in Greece: A pooled analysis across six seasons, 2013-2014 to 2018-2019.
CONCLUSION: Our results confirm the public health benefits from seasonal influenza vaccination, despite the suboptimal effectiveness against A(H3N2) strains. Continued monitoring of VE is essential, and routinely collected surveillance data can be valuable in this regard. PMID: 32033848 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 4, 2020 Category: Allergy & Immunology Authors: Mouratidou E, Lambrou A, Andreopoulou A, Gioula G, Exindari M, Kossyvakis A, Pogka V, Mentis A, Georgakopoulou T, Lytras T Tags: Vaccine Source Type: research

Lower respiratory infections mortality among Brazilians under-five before and after national pneumococcal conjugate vaccine implementation.
l;a E Abstract BACKGROUND: Studies on the impact of pneumococcal conjugate vaccines (PCV) on mortality, especially among preschoolers are scarce. We aimed to assess time trend mortality from lower respiratory infections (LRI), taken as a proxy of pneumonia, from 1990 to 2017. METHODS: This ecological study assessed the mortality rate among Brazilians under-five before and after the national PCV-10 implementation in 2010. Pneumococcal meningitis (PM) and diarrheal diseases (DD) were included as a "positive and negative controls", respectively. Trend analysis was performed through Global Burden of Dis...
Source: Vaccine - February 4, 2020 Category: Allergy & Immunology Authors: Camargos P, Nascimento-Carvalho CM, Teixeira R, França E Tags: Vaccine Source Type: research

Full genome based sequence and structural characterization of an unusual group A rotavirus G12P[11] isolated from neonates in Pune, western India.
Abstract Studies conducted at neonatal intensive care units in Pune, western India, suggested early exposure to rotaviruses and predominance of unusual human-bovine-like G12P[11] strains. The whole genome sequencing and phylogenetic analyses of a naturally attenuated, culture adapted neonatal strain, (NIV-1740121) revealed multiple-gene reassortment events, containing ROTAVAC® vaccine strain, 116E-like VP4, VP6, NSP3, NSP5 genes, VP7 gene of G12 origin and VP3 gene of porcine ancestry in a human Wa-like backbone. Analysis of 3D structure modeling of the VP7 and VP4 proteins with respect to 116E suggested amino...
Source: Vaccine - February 3, 2020 Category: Allergy & Immunology Authors: Ranshing SS, Cherian SS, Agarwal MS, Jagtap AS, Patil CM, Gopalkrishna V Tags: Vaccine Source Type: research

Awareness and knowledge of HPV and HPV vaccination among adults ages 27-45 years.
CONCLUSION: While more than half of adults ages 27-45 years are aware of HPV and HPV vaccination, there are opportunities to improve awareness and knowledge, particularly related to non-cervical cancers, as these are critical first steps toward shared decision-making for HPV vaccination in mid-adulthood. PMID: 32029321 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 3, 2020 Category: Allergy & Immunology Authors: Thompson EL, Wheldon CW, Rosen BL, Maness SB, Kasting ML, Massey PM Tags: Vaccine Source Type: research

Effects of rotavirus vaccine on all-cause acute gastroenteritis and rotavirus hospitalizations in Israel: A nationwide analysis.
Abstract BACKGROUND: In December 2010, the pentavalent rotavirus vaccine (RotaTeq) was added to the national immunization program in Israel. The study aim was to examine national reductions in all-cause acute gastroenteritis (AGE) and rotavirus gastroenteritis (RVGE) hospitalizations among children aged 0-59 months following the introduction of universal rotavirus immunization in Israel. METHODS: We extracted data from the Israel National Hospital Discharge Database. Hospitalization rates were calculated by dividing the annual number of all-cause AGE and RVGE hospitalizations by the number of children ag...
Source: Vaccine - February 3, 2020 Category: Allergy & Immunology Authors: Muhsen K, Haklai Z, Applbaum Y, Gordon ES, Shteiman A, Glatman-Freedman A, Leshem E Tags: Vaccine Source Type: research

Development of a guinea pig inhalational anthrax model for evaluation of post-exposure prophylaxis efficacy of anthrax vaccines.
Abstract A next-generation anthrax vaccine candidate, AV7909, is being developed for post-exposure prophylaxis (PEP) of inhalational anthrax in combination with the recommended course of antimicrobial therapy. Clinical efficacy studies of anthrax countermeasures in humans are not ethical or feasible, therefore, licensure of AV7909 for PEP is being pursued under the US Food and Drug Administration (FDA) Animal Rule, which requires that evidence of effectiveness be demonstrated in an animal model of anthrax, where results of studies in such a model can establish reasonable likelihood of AV7909 to produce clinical be...
Source: Vaccine - February 3, 2020 Category: Allergy & Immunology Authors: Perry MR, Ionin B, Barnewall RE, Vassar ML, Reece JJ, Park S, Lemiale L, Skiadopoulos MH, Shearer JD, Savransky V Tags: Vaccine Source Type: research

Application of a cost-effectiveness analysis of pathogen-specific vaccines against gastroenteritis to a military population in a developing country setting.
Abstract Vaccine implementation planning in low- and middle-income countries (LMIC) often focuses on children without considering special adult populations. We adapted an economic model developed by the United States Department of Defense (DoD) to evaluate the cost-effectiveness of vaccine acquisition strategies for Campylobacter-, ETEC-, Shigella-, and norovirus-associated gastroenteritis. We compared implementation costs with current medical management in the Peruvian armed forces, a special population of low- and middle-income (LMIC) adults with a high incidence of infectious gastroenteritis. Pathogen-specific ...
Source: Vaccine - February 1, 2020 Category: Allergy & Immunology Authors: Ballard SB, Tallant A, Guerra RG, Quigley D, Stiegmann R, Mirelman AJ, Riddle MS, Gilman RH, Norovirus Working Group in Peru Tags: Vaccine Source Type: research

The risk of febrile seizures following influenza and 13-valent pneumococcal conjugate vaccines.
CONCLUSIONS: We found an elevated risk of febrile seizures after PCV13 vaccine but not after IIV. The risk of febrile seizures after PCV13 is low compared to the overall risk in this population of children, and the risk should be interpreted in the context of the importance of preventing pneumococcal infections. PMID: 32019703 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 1, 2020 Category: Allergy & Immunology Authors: Baker MA, Jankosky C, Yih WK, Gruber S, Li L, Cocoros NM, Lipowicz H, Coronel-Moreno C, DeLuccia S, Lin ND, McMahill-Walraven CN, Menschik D, Selvan MS, Selvam N, Chen Tilney R, Zichittella L, Lee GM, Kawai AT Tags: Vaccine Source Type: research

Parents' hesitancy towards vaccination in Indonesia: A cross-sectional study in Indonesia.
CONCLUSIONS: Hesitancy towards pediatric vaccination is observed in 15% of respondents and most of the hesitancy was expressed in terms of vaccine safety and efficacy. Therefore, continuous dissemination of vaccine information needs to be carried out to earn parents' trust and increase vaccination coverage in Indonesia. PMID: 32019704 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - February 1, 2020 Category: Allergy & Immunology Authors: Yufika A, Wagner AL, Nawawi Y, Wahyuniati N, Anwar S, Yusri F, Haryanti N, Wijayanti NP, Rizal R, Fitriani D, Maulida NF, Syahriza M, Ikram I, Fandoko TP, Syahadah M, Asrizal FW, Aletta A, Haryanto S, Jamil KF, Mudatsir M, Harapan H Tags: Vaccine Source Type: research

Effectiveness and cost-effectiveness of a Clostridium difficile vaccine candidate in a hospital setting.
Abstract Toxoid vaccines against Clostridium difficile infections (CDI) appear promising in reducing the risk of developing toxin-mediated symptoms. We sought to evaluate the effectiveness and cost-effectiveness of a vaccine candidate in a hospital setting. We developed an agent-based simulation model of nosocomial CDI in a 300-bed hospital. Targeting high-risk patients for vaccination, we estimated the reduction of symptomatic CDI. Using the net reduction of CDI-associated isolation days, we evaluated the vaccine's cost-effectiveness from a healthcare provider perspective over a 2-year period with an average mont...
Source: Vaccine - February 1, 2020 Category: Allergy & Immunology Authors: Champredon D, Shoukat A, Moghadas SM Tags: Vaccine Source Type: research

Association between health insurance coverage and uptake of seasonal influenza vaccine in Brazos County, Texas.
CONCLUSIONS: Influenza vaccination is strongly associated with health insurance. Expansion of programs that facilitate access to health services or provide free influenza vaccines may improve influenza prevention among the uninsured. PMID: 32008878 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 31, 2020 Category: Allergy & Immunology Authors: Akpalu Y, Sullivan SJ, Regan AK Tags: Vaccine Source Type: research

Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model.
Abstract Cytomegalovirus is a leading cause of congenital disease and a vaccine is a high priority. The viral gB glycoprotein is essential for infection on all cell types. The guinea pig is the only small animal model for congenital CMV (cCMV), but requires guinea pig cytomegalovirus (GPCMV). Various GPCMV gB vaccine strategies have been investigated but not with a full length protein. Previous GPCMV gB vaccines have failed to fully protect against cCMV, with approximately 50% efficacy. In an effort to define the basis of GPCMV gB based vaccine failure, we evaluated recombinant defective Ad vectors encoding GPCMV ...
Source: Vaccine - January 31, 2020 Category: Allergy & Immunology Authors: Choi KY, El-Hamdi NS, McGregor A Tags: Vaccine Source Type: research

Trimeric HIV-1 gp140 fused with APRIL, BAFF, and CD40L on the mucosal gp140-specific antibody responses in mice.
Abstract HIV-1 envelope (Env)-specific antibody present at mucosal surfaces can block entry of HIV-1 into these portals and thus should be elicited by an HIV-1 preventive vaccine. Since three molecules of tumor necrosis factor superfamily (TNFSF), APRIL, BAFF, and CD40L, could promote mucosal antibody responses, we made fusion constructs of them with an HIV-1 gp140 trimer and tested the mucosal gp140-specific antibody elicited by the fusion constructs in mice using a DNA prime-protein boost vaccination regimen. The fusion constructs formed trimers and displayed both broadly neutralizing antibody epitopes and non-b...
Source: Vaccine - January 31, 2020 Category: Allergy & Immunology Authors: Liu J, Clayton K, Gao W, Li Y, Zealey C, Budylowski P, Schwartz J, Yue FY, Bie Y, Rini J, Ostrowski M Tags: Vaccine Source Type: research

Thimerosal-containing vaccines and deficit in child development: Population-based study in southern Brazil.
Abstract BACKGROUND: The discussion on the safety of thimerosal-containing vaccines (TCVs) and their impact on child development it́s very relevant. METHODS: This is a cohort study with mother-child dyads who received prenatal care in the Unified Health System. The domains of motor, cognitive and language development were evaluated in children between 24 and 36 months of age. Data on vaccination were obtained through the child's immunization record. A linear regression analysis was carried out considering possible confounders. RESULTS: In bivariate analyses, motor and language development were asso...
Source: Vaccine - January 31, 2020 Category: Allergy & Immunology Authors: da Cunha GK, de Matos MB, Trettim JP, Rubin BB, de Avila Quevedo L, Pinheiro KAT, da Cunha Coelho FM, Pinheiro RT Tags: Vaccine Source Type: research

Innate immunemodulator containing adjuvant formulated HA based vaccine protects mice from lethal infection of highly pathogenic avian influenza H5N1 virus.
Abstract The highly pathogenic avian influenza (HPAI) H5N1 viruses and their spillover into the human population pose substantial economic and public health threats. Although antiviral drugs have some effect in treating influenza infection, vaccination is still the most effective intervention to prevent possible pandemic outbreaks. We have developed a novel H5 influenza vaccine to improve the world's pandemic preparedness. We produced a hemagglutinin (HA) of HPAI H5N1 virus A/Alberta/01/2014 (AB14) using both mammalian (m) and bacterial (b) expression systems. The purified recombinant proteins were formulated with...
Source: Vaccine - January 31, 2020 Category: Allergy & Immunology Authors: Lu Y, Landreth S, Liu G, Brownlie R, Gaba A, Littel-van den Hurk SVD, Gerdts V, Zhou Y Tags: Vaccine Source Type: research

Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a nonhuman primate model.
Abstract Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea-associated illness in developing countries. There is currently no vaccine licensed to prevent ETEC and the development of an efficacious prophylaxis would provide an intervention with significant impact. Recent studies suggested that effective protection could be achieved by inducing immunity to block colonization of ETEC. Here, we evaluated the efficacy of secretory (s) IgA2 and dimeric (d) IgA2 of an anti-colonization factor antigen antibody, 68-61, in the Aotus nancymaae nonhuman primate (NHP) ETEC challenge model via oral and paren...
Source: Vaccine - January 30, 2020 Category: Allergy & Immunology Authors: Stoppato M, Gaspar C, Regeimbal J, Nunez RG, Giuntini S, Schiller ZA, Gawron MA, Pondish JR, Martin JC, Schneider MI, Klempner MS, Cavacini LA, Wang Y Tags: Vaccine Source Type: research

Minimal immune response to booster vaccination against Yellow Fever associated with pre-existing antibodies.
co SA Abstract Ever since its development in the 1930's, the live-attenuated Yellow Fever virus vaccine YF-17D has been highly effective. Despite the increasing knowledge on the immune biology of the YF-17D vaccine, most studies have focused only on a few types of immune cells and pathways or mainly on the primary adaptive immune response to YF-17D vaccination. Here, we examined humoral, innate and adaptive cellular responses in a longitudinal YF-17D vaccination study in Switzerland, comparing both primary and booster vaccination. In contrast to the strong innate and adaptive immune response to the primary vaccina...
Source: Vaccine - January 30, 2020 Category: Allergy & Immunology Authors: Bovay A, Nassiri S, Maby-El Hajjami H, Marcos Mondéjar P, Akondy RS, Ahmed R, Lawson B, Speiser DE, Fuertes Marraco SA Tags: Vaccine Source Type: research

Men having sex with men and the HPV vaccine in France: A low vaccine coverage that may be due to its infrequent proposal by physicians.
Abstract INTRODUCTION: In France, the human papilloma (HPV) vaccine is recommended to all female adolescents, and since 2016 to men having sex with men (MSM) under the age of 27. Here, we aimed to explore HPV vaccine coverage in adult MSM living in France. METHODS: We elaborated an anonymous online questionnaire targeting MSM and disseminated it between October 7, 2018 and January 15, 2019 by various means, including a Facebook® discussion forum for pre-exposure prophylaxis (PrEP) users. RESULTS: Overall, 2094 participants completed the questionnaire (mean age 35.4 ± 11 years); ...
Source: Vaccine - January 30, 2020 Category: Allergy & Immunology Authors: Petit B, Epaulard O Tags: Vaccine Source Type: research

Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice.
In conclusion, we found no apparent advantage for mixtures of predominant pre-fusion F proteins over post-fusion conformations for hMPV vaccination in opposite to recent data obtained with the human respiratory syncytial virus. PMID: 32007293 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 29, 2020 Category: Allergy & Immunology Authors: Pilaev M, Shen Y, Carbonneau J, Venable MC, Rhéaume C, Lavigne S, Couture C, Guarné A, Hamelin MÈ, Boivin G Tags: Vaccine Source Type: research

Maternal knowledge and infant uptake of valid hepatitis B vaccine birth dose at routine immunization clinics in Enugu State - Nigeria.
CONCLUSION: Knowledge and uptake of valid HepB-BD were low. Health education on benefits of valid HepB-BD was given to mothers after administration of questionnaires. We disseminated findings to the State Ministry of Health and recommended integration of child delivery and immunization services for birth dose vaccines especially valid HepB-BD. PMID: 32007294 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 29, 2020 Category: Allergy & Immunology Authors: Okenwa UJ, Dairo MD, Bamgboye E, Ajumobi O Tags: Vaccine Source Type: research

Finding equipoise: CEPI revises its equitable access policy.
Abstract Launched at Davos in January 2017 with funding from sovereign investors and philanthropic institutions, the Coalition for Epidemic Preparedness Innovations (CEPI) is an innovative partnership between public, private, philanthropic, and civil organisations whose mission is to stimulate, finance and co-ordinate vaccine development against diseases with epidemic potential in cases where market incentives fail. As of December 2019, CEPI has committed to investing up to $706 million in vaccine development. This includes 19 vaccine candidates against its priority pathogens (Lassa fever virus, Middle East respir...
Source: Vaccine - January 28, 2020 Category: Allergy & Immunology Authors: Huneycutt B, Lurie N, Rotenberg S, Wilder R, Hatchett R Tags: Vaccine Source Type: research

Isolation and characterization of new human carrier peptides from two important vaccine immunogens.
This study serves toward understanding carrier protein immune responses and thus enables the use of these peptides in developing novel knowledge-based vaccines to combat persisting problems in glycoconjugate vaccine design. PMID: 32005537 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 28, 2020 Category: Allergy & Immunology Authors: Wantuch PL, Sun L, LoPilato RK, Mousa JJ, Haltiwanger RS, Avci FY Tags: Vaccine Source Type: research

Vaccine hesitancy towards childhood immunisation amongst urban pregnant mothers in Malaysia.
Abstract BACKGROUND: Vaccine hesitancy is a complex behaviour which involves various degrees of indecision about specific vaccines or vaccination uptake. Access to antenatal care had been associated with positive vaccine behavior. OBJECTIVE: To determine the prevalence of vaccine hesitancy towards childhood immunisation amongst urban pregnant mothers and the associated socio-demographic factors. METHODS: A cross-sectional study was conducted among 1081 women who received antenatal care at a teaching hospital in Kuala Lumpur. Vaccine hesitancy was assessed using the Parent Attitudes about Childhood Vaccin...
Source: Vaccine - January 27, 2020 Category: Allergy & Immunology Authors: Kalok A, Loh SYE, Chew KT, Abdul Aziz NH, Shah SA, Ahmad S, Mohamed Ismail NA, Abdullah Mahdy Z Tags: Vaccine Source Type: research

Transcutaneous immunization with a nontypeable Haemophilus influenzae dual adhesin-directed immunogen induces durable and boostable immunity.
Abstract Otitis media (OM) is a very common pediatric disease and nontypeable Haemophilus influenzae (NTHI) is the predominant causative agent. We've developed a chimeric immunogen, chimV4, that simultaneously targets two NTHI adhesins, OMP P5 and the type IV pilus. Transcutaneous immunization (TCI) via bandaid with chimV4 plus the adjuvant dmLT provides significant protection against experimental NTHI-induced OM in chinchilla models. Herein, we now examined the durability and boostability of the induced immune response. Bandaid immunization with chimV4+dmLT followed by two sequential middle ear challenges with NT...
Source: Vaccine - January 27, 2020 Category: Allergy & Immunology Authors: Novotny LA, Bakaletz LO Tags: Vaccine Source Type: research

Acceptability of seasonal influenza vaccines among health care workers in Vietnam in 2017.
Abstract INTRODUCTION: A demonstration project in Vietnam provided 11,000 doses of human seasonal influenza vaccine free of charge to healthcare workers (HCWs) in 4 provinces of Vietnam. Through this project, we conducted an acceptability survey to identify the main reasons that individuals chose to be vaccinated or not to inform and improve future immunization activities. METHODS: We conducted a descriptive cross-sectional survey from May to August 2017 among HCWs at 13 selected health facilities. We employed logistic regression to determine the association between demographic and professional factors, and t...
Source: Vaccine - January 27, 2020 Category: Allergy & Immunology Authors: Nguyen TTM, Lafond KE, Nguyen TX, Tran PD, Nguyen HM, Ha VTC, Do TT, Ha NT, Seward JF, McFarland JW Tags: Vaccine Source Type: research

Survey of influenza vaccine knowledge, attitudes, and beliefs among pregnant women in the 2016-17 season.
Abstract OBJECTIVES: Influenza vaccination coverage among pregnant women in the United States is suboptimal. We surveyed women who were pregnant during the 2016-17 influenza season to assess knowledge and attitudes regarding influenza vaccination. METHODS: We identified and sampled pregnant women to include approximately equal numbers of vaccinated and unvaccinated women from strata defined by vaccination status and trimester from four integrated health systems in the Vaccine Safety Datalink (VSD). Potential participants were contacted via mail and telephone to complete a standardized survey. Characteristics ...
Source: Vaccine - January 25, 2020 Category: Allergy & Immunology Authors: King JP, Hanson KE, Donahue JG, Glanz JM, Klein NP, Naleway AL, DeStefano F, Weintraub E, Belongia EA Tags: Vaccine Source Type: research

Perceptions among the U.S. population of value of Japanese encephalitis (JE) vaccination for travel to JE-endemic countries.
CONCLUSIONS: There is population heterogeneity in perception of JE disease risk and value of vaccination. PMID: 31992482 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 25, 2020 Category: Allergy & Immunology Authors: Hills SL, Fischer M, Biggerstaff BJ Tags: Vaccine Source Type: research

Pandemic influenza A(H1N1pdm09) vaccine induced high levels of influenza-specific IgG and IgM antibodies as analyzed by enzyme immunoassay and dual-mode multiplex microarray immunoassay methods.
Julkunen I Abstract Influenza A viruses continue to circulate throughout the world as yearly epidemics or occasional pandemics. Influenza infections can be prevented by seasonal multivalent or monovalent pandemic vaccines. In the present study, we describe a novel multiplex microarray immunoassay (MAIA) for simultaneous measurement of virus-specific IgG and IgM antibodies using Pandemrix-vaccinated adult sera collected at day 0 and 28 and 180 days after vaccination as the study material. MAIA showed excellent correlation with a conventional enzyme immunoassay (EIA) in both IgG and IgM anti-influenza A antibo...
Source: Vaccine - January 24, 2020 Category: Allergy & Immunology Authors: Kazakova A, Kakkola L, Ziegler T, Syrjänen R, Päkkilä H, Waris M, Soukka T, Julkunen I Tags: Vaccine Source Type: research

The science of vaccine safety: Summary of meeting at Wellcome Trust.
The objective of the meeting was to assess what is known beyond reasonable doubt and conversely what areas need additional studies. Although the meeting could not cover all aspects of vaccine safety science, many of the most important issues were addressed by a group of about 30 experts to determine what is already known and what additional studies are merited to assess the safety of the vaccines currently in use. The meeting began with reviews of the current situation in different parts of the world, followed by reviews of specific controversial areas, including the incidence of certain conditions after vaccination and th...
Source: Vaccine - January 24, 2020 Category: Allergy & Immunology Authors: Plotkin SA, Offit PA, DeStefano F, Larson HJ, Arora NK, Zuber PLF, Fombonne E, Sejvar J, Lambert PH, Hviid A, Halsey N, Garçon N, Peden K, Pollard AJ, Markowitz LE, Glanz J Tags: Vaccine Source Type: research

Seroprotection rate in adults after 1-dose, 2-dose, and 3-dose series of a reduced-diphtheria-tetanus toxoid vaccine (Td) during a diphtheria outbreak in Thailand.
Abstract To evaluate seroprotection of different dosing strategies of reduced-diphtheria-tetanus-toxoid vaccine (Td) for adults during a diphtheria outbreak in Thailand, we enrolled 160 healthcare workers and 161 adults aged 20-60 years old and measured diphtheria antitoxin (DAT) level before administration of a Td vaccine. We scheduled a second Td at 4-8 weeks and a third Td at 6-12 months interval. DAT was measured 4 weeks after each dose. DAT levels of ≥0.1 and ≥1 IU/mL were considered as seroprotective and long-term seroprotective. Persons achieving long-term seroprotection were ...
Source: Vaccine - January 24, 2020 Category: Allergy & Immunology Authors: Suntarattiwong P, Vandepitte WP, Singhamatr P, Chotpitayasunondh T Tags: Vaccine Source Type: research

Live attenuated MMR/V booster vaccines in children with rheumatic diseases on immunosuppressive therapy are safe: Multicenter, retrospective data collection.
CONCLUSIONS: In this retrospective study, live-attenuated MMR/V booster vaccines were safe for children with rheumatic diseases, on immunosuppressive therapies. This strengthens the Paediatric Rheumatology European Society (PReS) recommendation that vaccination with live attenuated vaccines in patients on immunosuppressive therapies can be considered individually, weighing the benefit of vaccination against the risk of inducing infection through vaccination. These data provide the basis for a prospective data collection study, planned by the PReS vaccination study group. PMID: 31987692 [PubMed - as supplied by publish...
Source: Vaccine - January 24, 2020 Category: Allergy & Immunology Authors: Uziel Y, Moshe V, Onozo B, Kulcsár A, Tróbert-Sipos D, Akikusa JD, Salviato Pileggi G, Maritsi D, Kasapcopur O, Rodrigues M, Smerla R, Rigante D, Makay B, Atsali E, Wulffraat N, Toplak N, PReS working party of Vaccination Study Group Tags: Vaccine Source Type: research