Strategy to identify priority groups for COVID-19 vaccination: A population based cohort study
CONCLUSION: This approach defines a two-level stratification for priorities in the vaccination that can easily be applied by health authorities, eventually adapted to local results in terms of number and types of comorbidities, and rapidly updated with current data. After the early phase of vaccination, data on effectiveness and safety will give the opportunity to revise prioritization and discuss the future approach in the remaining population.PMID:33824037 | DOI:10.1016/j.vaccine.2021.03.076 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Antonio Giampiero Russo Adriano Decarli Maria Grazia Valsecchi Source Type: research

Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines
Vaccine. 2021 Apr 3:S0264-410X(21)00384-4. doi: 10.1016/j.vaccine.2021.03.078. Online ahead of print.ABSTRACTFor batch release of legacy vaccines such as DTaP, in vivo potency release assays are required. We quantified the variability of in vivo potency release assays for four DTaP (Diphtheria, Tetanus, acellular Pertussis) products of different manufacturers. With their large CV (Coefficients of Variance) ranging from 16% to 132%, these in vivo assays are of limited value to ensure their potency is consistent and similar to the clinical batches used for the marketing authorisation. Our data show that, although individual ...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Coen A L Stalpers Irene A Retmana Jeroen L A Pennings Rob J Vandebriel Coenraad F M Hendriksen Arnoud M Akkermans Marcel H N Hoefnagel Source Type: research

Modeling and presentation of vaccination coverage estimates using data from household surveys
Vaccine. 2021 Apr 3:S0264-410X(21)00275-9. doi: 10.1016/j.vaccine.2021.03.007. Online ahead of print.ABSTRACTIt is becoming increasingly popular to produce high-resolution maps of vaccination coverage by fitting Bayesian geostatistical models to data from household surveys. Usually, the surveys adopt a stratified cluster sampling design. We discuss a number of crucial choices with respect to two key aspects of the map production process: the acknowledgement of the survey design in modeling, and the appropriate presentation of estimates and their uncertainties. Specifically, we consider the importance of accounting for urba...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Tracy Qi Dong Jon Wakefield Source Type: research

Negligible risk of rabies importation in dogs thirty days after demonstration of adequate serum antibody titer
Vaccine. 2021 Apr 4:S0264-410X(21)00368-6. doi: 10.1016/j.vaccine.2021.03.064. Online ahead of print.NO ABSTRACTPMID:33824040 | DOI:10.1016/j.vaccine.2021.03.064 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Todd G Smith Anthony R Fooks Susan M Moore Conrad M Freuling Thomas M üller Gregorio Torres Ryan M Wallace Source Type: research

Invasive pneumococcal disease in Canada 2010-2017: The role of current and next-generation higher-valent pneumococcal conjugate vaccines
Vaccine. 2021 Apr 3:S0264-410X(21)00260-7. doi: 10.1016/j.vaccine.2021.02.069. Online ahead of print.ABSTRACTBACKGROUND: In 2010-2011, the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7- or 10-valent vaccine (PCV7 and PCV10, respectively) in pediatric immunization programs across Canada. For adults aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine (PPSV23) has been publicly funded for several decades; PCV13 funding was not recommended in this population, partly due to expected ongoing vaccine-serotype disease decline stemming from herd effects of the pediatric program. Higher-valent PCVs...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Stephane B Dion Maria Major Ana Gabriela Grajales Rajeev M Nepal Alejandro Cane Bradford Gessner Jelena Vojicic Jose A Suaya Source Type: research

Anti-SARS-CoV-2 RBD IgG responses in convalescent versus naive BNT162b2 vaccine recipients
Vaccine. 2021 Mar 30:S0264-410X(21)00402-3. doi: 10.1016/j.vaccine.2021.03.086. Online ahead of print.NO ABSTRACTPMID:33824042 | DOI:10.1016/j.vaccine.2021.03.086 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Lorenzo Azzi Daniele Focosi Francesco Dentali Andreina Baj Fabrizio Maggi Source Type: research

The development of COVID-19 vaccines in the United States: Why and how so fast?
Vaccine. 2021 Mar 26:S0264-410X(21)00383-2. doi: 10.1016/j.vaccine.2021.03.077. Online ahead of print.NO ABSTRACTPMID:33824043 | DOI:10.1016/j.vaccine.2021.03.077 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Barbara J Kuter Paul A Offit Gregory A Poland Source Type: research

Strategy to identify priority groups for COVID-19 vaccination: A population based cohort study
CONCLUSION: This approach defines a two-level stratification for priorities in the vaccination that can easily be applied by health authorities, eventually adapted to local results in terms of number and types of comorbidities, and rapidly updated with current data. After the early phase of vaccination, data on effectiveness and safety will give the opportunity to revise prioritization and discuss the future approach in the remaining population.PMID:33824037 | DOI:10.1016/j.vaccine.2021.03.076 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Antonio Giampiero Russo Adriano Decarli Maria Grazia Valsecchi Source Type: research

Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines
Vaccine. 2021 Apr 3:S0264-410X(21)00384-4. doi: 10.1016/j.vaccine.2021.03.078. Online ahead of print.ABSTRACTFor batch release of legacy vaccines such as DTaP, in vivo potency release assays are required. We quantified the variability of in vivo potency release assays for four DTaP (Diphtheria, Tetanus, acellular Pertussis) products of different manufacturers. With their large CV (Coefficients of Variance) ranging from 16% to 132%, these in vivo assays are of limited value to ensure their potency is consistent and similar to the clinical batches used for the marketing authorisation. Our data show that, although individual ...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Coen A L Stalpers Irene A Retmana Jeroen L A Pennings Rob J Vandebriel Coenraad F M Hendriksen Arnoud M Akkermans Marcel H N Hoefnagel Source Type: research

Modeling and presentation of vaccination coverage estimates using data from household surveys
Vaccine. 2021 Apr 3:S0264-410X(21)00275-9. doi: 10.1016/j.vaccine.2021.03.007. Online ahead of print.ABSTRACTIt is becoming increasingly popular to produce high-resolution maps of vaccination coverage by fitting Bayesian geostatistical models to data from household surveys. Usually, the surveys adopt a stratified cluster sampling design. We discuss a number of crucial choices with respect to two key aspects of the map production process: the acknowledgement of the survey design in modeling, and the appropriate presentation of estimates and their uncertainties. Specifically, we consider the importance of accounting for urba...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Tracy Qi Dong Jon Wakefield Source Type: research

Negligible risk of rabies importation in dogs thirty days after demonstration of adequate serum antibody titer
Vaccine. 2021 Apr 4:S0264-410X(21)00368-6. doi: 10.1016/j.vaccine.2021.03.064. Online ahead of print.NO ABSTRACTPMID:33824040 | DOI:10.1016/j.vaccine.2021.03.064 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Todd G Smith Anthony R Fooks Susan M Moore Conrad M Freuling Thomas M üller Gregorio Torres Ryan M Wallace Source Type: research

Invasive pneumococcal disease in Canada 2010-2017: The role of current and next-generation higher-valent pneumococcal conjugate vaccines
Vaccine. 2021 Apr 3:S0264-410X(21)00260-7. doi: 10.1016/j.vaccine.2021.02.069. Online ahead of print.ABSTRACTBACKGROUND: In 2010-2011, the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7- or 10-valent vaccine (PCV7 and PCV10, respectively) in pediatric immunization programs across Canada. For adults aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine (PPSV23) has been publicly funded for several decades; PCV13 funding was not recommended in this population, partly due to expected ongoing vaccine-serotype disease decline stemming from herd effects of the pediatric program. Higher-valent PCVs...
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Stephane B Dion Maria Major Ana Gabriela Grajales Rajeev M Nepal Alejandro Cane Bradford Gessner Jelena Vojicic Jose A Suaya Source Type: research

Anti-SARS-CoV-2 RBD IgG responses in convalescent versus naive BNT162b2 vaccine recipients
Vaccine. 2021 Mar 30:S0264-410X(21)00402-3. doi: 10.1016/j.vaccine.2021.03.086. Online ahead of print.NO ABSTRACTPMID:33824042 | DOI:10.1016/j.vaccine.2021.03.086 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Lorenzo Azzi Daniele Focosi Francesco Dentali Andreina Baj Fabrizio Maggi Source Type: research

The development of COVID-19 vaccines in the United States: Why and how so fast?
Vaccine. 2021 Mar 26:S0264-410X(21)00383-2. doi: 10.1016/j.vaccine.2021.03.077. Online ahead of print.NO ABSTRACTPMID:33824043 | DOI:10.1016/j.vaccine.2021.03.077 (Source: Vaccine)
Source: Vaccine - April 7, 2021 Category: Allergy & Immunology Authors: Barbara J Kuter Paul A Offit Gregory A Poland Source Type: research

The role of multiple SARS-CoV-2 viral antigens in a vaccine-induced integrated immune response
Vaccine. 2021 Mar 22:S0264-410X(21)00371-6. doi: 10.1016/j.vaccine.2021.03.067. Online ahead of print.NO ABSTRACTPMID:33814228 | PMC:PMC7983451 | DOI:10.1016/j.vaccine.2021.03.067 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Ying Zhang Dandan Li Heng Zhao Lichun Wang Yun Liao Xueqi Li Tangwei Mou Qihan Li Source Type: research

Lack of neonatal Fc receptor does not diminish the efficacy of the HSV-1 0deltaNLS vaccine against ocular HSV-1 challenge
Vaccine. 2021 Apr 1:S0264-410X(21)00379-0. doi: 10.1016/j.vaccine.2021.03.075. Online ahead of print.ABSTRACTThe neonatal Fc receptor (FcRn) is constitutively expressed in the cornea and is up-regulated in response to herpes simplex virus type 1 (HSV-1). Previously, we found targeting cornea FcRn expression by small interfering RNA-mediated knockdown reduced the local efficacy of HSV-1 0ΔNLS vaccinated C57BL/6 mice against ocular challenge with HSV-1. The current study was undertaken to evaluate the HSV-1 0ΔNLS vaccine efficacy in FcRn deficient (FcRn KO) mice challenged with HSV-1. Whereas there was little neu...
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Daniel J J Carr Amanda N Berube Adrian Filiberti Grzegorz B Gmyrek Source Type: research

The impact of two-dose varicella vaccination on varicella and herpes zoster incidence in South Korea using a mathematical model with changing population demographics
CONCLUSION: A two-dose varicella vaccination schedule would significantly reduce varicella and HZ incidence in the long term. A second dose at the age of 18 months with a catch-up vaccination of 6-year-olds would be optimal for controlling varicella in South Korea.PMID:33814230 | DOI:10.1016/j.vaccine.2021.03.056 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Jiyeon Suh Taeyong Lee Jae-Ki Choi Jeehyun Lee Sun Hee Park Source Type: research

Long-term persistent immunogenicity after successful standard and triple-dosed hepatitis B vaccine in hemodialysis patients: A 3-year follow-up study in China
CONCLUSION: High-dose 60 μg hepatitis B vaccine could lead a satisfactory long-term durability of immunogenicity among patients with hemodialysis duration of five years or more. Peak anti-HBs level after vaccination was associated with the long-term persistence of immunogenicity.PMID:33814231 | DOI:10.1016/j.vaccine.2021.03.074 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Tian Yao Zhihong Shao Lina Wu Shuang Dong Linying Gao Yuanting Wu Xiaohong Shi Jing Shi Guangming Liu Jianmin Wang Huilin Zhao Hongping Guo Hongting Liu Xiaofeng Wu Liming Liu Xiaohui Song Jiangtao Zhu Yawei Zhang Yongliang Feng Xiaofeng Liang Suping Wang Source Type: research

Clinical repercussions in pertussis infants post-Tdpa vaccination of pregnant woman: An immunization success?
CONCLUSIONS: Maternal immunization with Tdap decreased disease severity, complication rates, and no deaths occurred in infants under 6 months of age diagnosed with pertussis.PMID:33814232 | DOI:10.1016/j.vaccine.2021.03.069 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Katiuscia Araujo de Miranda Lopes Paulo Neves Baptista Renata de Medeiros Nascimento Anal íria Pimentel Ricardo Arraes de Alencar Ximenes Source Type: research

Pichia pastoris displaying ZIKV protein epitopes from the Envelope and NS1 induce in vitro immune activation
Vaccine. 2021 Apr 1:S0264-410X(21)00369-8. doi: 10.1016/j.vaccine.2021.03.065. Online ahead of print.ABSTRACTThe severe consequences of ZIKV infection and its emergence and re-emergence in several countries have boosted vaccines' development. Yeasts such as Pichia pastoris has been widely employed as antigen carriers for immunization against infectious agents. Components of the yeast cell wall have immunostimulatory properties, and recombinant antigens can be anchored to the cell surface to enhance the presentation to the immune system. Here we aimed at producing and anchoring ZIKV proteins in the P. pastoris surface as a ...
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Anna J éssica D Silva Andr é Luiz S Jesus L ígia Rosa S Leal Guilherme Antonio S Silva Cristiane Moutinho L Melo Antonio C Freitas Source Type: research

Saponin-adjuvanted recombinant vaccines containing rCP00660, rCP09720 or rCP01850 proteins against Corynebacterium pseudotuberculosis infection in mice
CONCLUSION: rCP01850 added by saponin was able to protect efficiently mice against C. pseudotuberculosis challenge, and to induce high IgG, IFN-γ and TNF-α levels. In spite of rCP00660 and rCP09720 had not same adequate protection levels, significant IgG, IFN-γ, and IL-17 levels and further studies aiming to improve protection rates should be conducted.PMID:33814234 | DOI:10.1016/j.vaccine.2021.03.062 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Francisco Silvestre Brilhante Bezerra Mara Thais de Oliveira Silva Andrea de F átima Silva Rezende Angela Sena Lopes Rodrigo Barros de Pinho Fabiana Kommling Seixas Tiago Veiras Collares Ricardo Wagner Dias Portela Vasco Ariston de Carvalho Azevedo Sibel Source Type: research

The role of multiple SARS-CoV-2 viral antigens in a vaccine-induced integrated immune response
Vaccine. 2021 Mar 22:S0264-410X(21)00371-6. doi: 10.1016/j.vaccine.2021.03.067. Online ahead of print.NO ABSTRACTPMID:33814228 | DOI:10.1016/j.vaccine.2021.03.067 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Ying Zhang Dandan Li Heng Zhao Lichun Wang Yun Liao Xueqi Li Tangwei Mou Qihan Li Source Type: research

Lack of neonatal Fc receptor does not diminish the efficacy of the HSV-1 0deltaNLS vaccine against ocular HSV-1 challenge
Vaccine. 2021 Apr 1:S0264-410X(21)00379-0. doi: 10.1016/j.vaccine.2021.03.075. Online ahead of print.ABSTRACTThe neonatal Fc receptor (FcRn) is constitutively expressed in the cornea and is up-regulated in response to herpes simplex virus type 1 (HSV-1). Previously, we found targeting cornea FcRn expression by small interfering RNA-mediated knockdown reduced the local efficacy of HSV-1 0ΔNLS vaccinated C57BL/6 mice against ocular challenge with HSV-1. The current study was undertaken to evaluate the HSV-1 0ΔNLS vaccine efficacy in FcRn deficient (FcRn KO) mice challenged with HSV-1. Whereas there was little neu...
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Daniel J J Carr Amanda N Berube Adrian Filiberti Grzegorz B Gmyrek Source Type: research

The impact of two-dose varicella vaccination on varicella and herpes zoster incidence in South Korea using a mathematical model with changing population demographics
CONCLUSION: A two-dose varicella vaccination schedule would significantly reduce varicella and HZ incidence in the long term. A second dose at the age of 18 months with a catch-up vaccination of 6-year-olds would be optimal for controlling varicella in South Korea.PMID:33814230 | DOI:10.1016/j.vaccine.2021.03.056 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Jiyeon Suh Taeyong Lee Jae-Ki Choi Jeehyun Lee Sun Hee Park Source Type: research

Long-term persistent immunogenicity after successful standard and triple-dosed hepatitis B vaccine in hemodialysis patients: A 3-year follow-up study in China
CONCLUSION: High-dose 60 μg hepatitis B vaccine could lead a satisfactory long-term durability of immunogenicity among patients with hemodialysis duration of five years or more. Peak anti-HBs level after vaccination was associated with the long-term persistence of immunogenicity.PMID:33814231 | DOI:10.1016/j.vaccine.2021.03.074 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Tian Yao Zhihong Shao Lina Wu Shuang Dong Linying Gao Yuanting Wu Xiaohong Shi Jing Shi Guangming Liu Jianmin Wang Huilin Zhao Hongping Guo Hongting Liu Xiaofeng Wu Liming Liu Xiaohui Song Jiangtao Zhu Yawei Zhang Yongliang Feng Xiaofeng Liang Suping Wang Source Type: research

Clinical repercussions in pertussis infants post-Tdpa vaccination of pregnant woman: An immunization success?
CONCLUSIONS: Maternal immunization with Tdap decreased disease severity, complication rates, and no deaths occurred in infants under 6 months of age diagnosed with pertussis.PMID:33814232 | DOI:10.1016/j.vaccine.2021.03.069 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Katiuscia Araujo de Miranda Lopes Paulo Neves Baptista Renata de Medeiros Nascimento Anal íria Pimentel Ricardo Arraes de Alencar Ximenes Source Type: research

Pichia pastoris displaying ZIKV protein epitopes from the Envelope and NS1 induce in vitro immune activation
Vaccine. 2021 Apr 1:S0264-410X(21)00369-8. doi: 10.1016/j.vaccine.2021.03.065. Online ahead of print.ABSTRACTThe severe consequences of ZIKV infection and its emergence and re-emergence in several countries have boosted vaccines' development. Yeasts such as Pichia pastoris has been widely employed as antigen carriers for immunization against infectious agents. Components of the yeast cell wall have immunostimulatory properties, and recombinant antigens can be anchored to the cell surface to enhance the presentation to the immune system. Here we aimed at producing and anchoring ZIKV proteins in the P. pastoris surface as a ...
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Anna J éssica D Silva Andr é Luiz S Jesus L ígia Rosa S Leal Guilherme Antonio S Silva Cristiane Moutinho L Melo Antonio C Freitas Source Type: research

Saponin-adjuvanted recombinant vaccines containing rCP00660, rCP09720 or rCP01850 proteins against Corynebacterium pseudotuberculosis infection in mice
CONCLUSION: rCP01850 added by saponin was able to protect efficiently mice against C. pseudotuberculosis challenge, and to induce high IgG, IFN-γ and TNF-α levels. In spite of rCP00660 and rCP09720 had not same adequate protection levels, significant IgG, IFN-γ, and IL-17 levels and further studies aiming to improve protection rates should be conducted.PMID:33814234 | DOI:10.1016/j.vaccine.2021.03.062 (Source: Vaccine)
Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Francisco Silvestre Brilhante Bezerra Mara Thais de Oliveira Silva Andrea de F átima Silva Rezende Angela Sena Lopes Rodrigo Barros de Pinho Fabiana Kommling Seixas Tiago Veiras Collares Ricardo Wagner Dias Portela Vasco Ariston de Carvalho Azevedo Sibel Source Type: research

Oral and laryngeal HPV infection: Incidence, prevalence and risk factors, with special regard to concurrent infection in head, neck and genitals
Vaccine. 2021 Mar 31:S0264-410X(21)00340-6. doi: 10.1016/j.vaccine.2021.03.047. Online ahead of print.ABSTRACTThis review focuses on the importance of oral and laryngeal HPV infection which is present in majority of sexually active individuals at least once in their lifetime. Despite testing, still little is known about prevalence rates, determinants and, especially, the concurrent HPV infection in head and neck, and genitals. The purpose of this review is to clarify some issues of oral HPV incidence, prevalence, and to demonstrate the difficulties in identification of asymptomatic oral HPV carriers. The main premise to ta...
Source: Vaccine - April 4, 2021 Category: Allergy & Immunology Authors: Malgorzata Wierzbicka Jens Peter Klussmann Michel R San Giorgi Nora Wuerdemann Frederik G Dikkers Source Type: research

Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis
Vaccine. 2021 Mar 31:S0264-410X(21)00363-7. doi: 10.1016/j.vaccine.2021.03.059. Online ahead of print.ABSTRACTCurrently there is no human vaccine against Lyme borreliosis, and most research focuses on recombinant protein vaccines, as such a vaccine has been proven to be successful in the past. The expression of recombinant antigens in meningococcal Outer Membrane Vesicles (OMVs), with the OMV functioning both as adjuvant and delivery vehicle, greatly enhances their potential. Immunization studies in mice have shown that OMV-based vaccines can protect against various pathogens and an OMV-based meningococcal vaccine is appro...
Source: Vaccine - April 4, 2021 Category: Allergy & Immunology Authors: M J Klouwens M L M Salverda J J Trentelman J I Ersoz A Wagemakers M J H Gerritzen P A van der Ley J W Hovius Source Type: research

Projecting the impact of a two-dose COVID-19 vaccination campaign in Ontario, Canada
CONCLUSIONS: Vaccination can substantially mitigate ongoing COVID-19 outbreaks. Sustaining population-wide NPIs, to allow for a sufficient increase in population-level immunity through vaccination, is essential to prevent future outbreaks.PMID:33812742 | DOI:10.1016/j.vaccine.2021.03.058 (Source: Vaccine)
Source: Vaccine - April 4, 2021 Category: Allergy & Immunology Authors: Thomas N Vilches Kevin Zhang Robert Van Exan Joanne M Langley Seyed M Moghadas Source Type: research

A randomized, controlled trial comparing the immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccination to a repeated dose 13-valent pneumococcal conjugate vaccination in adult liver transplant recipients
CONCLUSIONS: The immunogenicity of PPV23 and PCV13 was comparable in this patient material, but the seroresponses waned after transplantation. The second dose of PCV13 restored the immune responses and was well tolerated.PMID:33812743 | DOI:10.1016/j.vaccine.2021.03.063 (Source: Vaccine)
Source: Vaccine - April 4, 2021 Category: Allergy & Immunology Authors: Mari Eriksson Helena K äyhty Mika Lahdenkari Heikki M äkisalo Veli-Jukka Anttila Source Type: research

The safety of BCG revaccination: A systematic review
CONCLUSIONS: Evidence to date suggests that revaccination with BCG vaccine carries minimal risk. Future studies of BCG vaccine for novel applications should report adverse event data stratified by prior BCG vaccination status.PMID:33810902 | DOI:10.1016/j.vaccine.2020.08.016 (Source: Vaccine)
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Samantha Bannister Eva Sudbury Paola Villanueva Kirsten Perrett Nigel Curtis Source Type: research

A retrospective cohort study assessing relative effectiveness of adjuvanted versus high-dose trivalent influenza vaccines among older adults in the United States during the 2018-19 influenza season
Vaccine. 2021 Mar 30:S0264-410X(21)00347-9. doi: 10.1016/j.vaccine.2021.03.054. Online ahead of print.ABSTRACTPURPOSE: To evaluate the relative vaccine effectiveness (rVE) against influenza-related hospitalizations/emergency room (ER) visits, influenza-related office visits, and cardio-respiratory disease (CRD)-related hospitalizations/ER visits and compare all-cause and influenza-related costs associated with two vaccines specifically indicated for older adults (≥65 years), adjuvanted (aTIV) and high-dose trivalent influenza vaccine (TIV-HD), for the 2018-19 influenza season.METHODS: A retrospective analysis of older a...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Stephen I Pelton Victoria Divino Maarten J Postma Drishti Shah Joaquin Mould-Quevedo Mitch DeKoven Girishanthy Krishnarajah Source Type: research

Immunogenicity and safety of sabin-strain based inactivated poliovirus vaccine replacing salk-strain based inactivated poliovirus vaccine: An innovative application of different strain-IPVs replacement
Vaccine. 2021 Mar 30:S0264-410X(21)00264-4. doi: 10.1016/j.vaccine.2021.02.073. Online ahead of print.ABSTRACTBACKGROUND: A domestic Sabin strain-based inactivated poliovirus vaccine (Sabin IPV) was approved by China Food and Drug Administration in 2017 as a replacement for the Salk strain-based inactivated poliovirus vaccine (Salk IPV) that has been in use in China for over 10 years. The present post-marketing trial was implemented in China to assess the immunogenicity and safety of replacing the Salk IPV with the Sabin IPV in the last two immunizations of the standard three-dose schedule.METHODS: We conducted a randomize...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Haiping Chen Zhigang Gao Shuang Bai Xiaoqin Liu Shasha Han Yanhui Xiao Fang Liu Yinghong Yu Hongmei Sun Xiaoming Yang Source Type: research

Media usage predicts intention to be vaccinated against SARS-CoV-2 in the US and the UK
Vaccine. 2021 Mar 16:S0264-410X(21)00234-6. doi: 10.1016/j.vaccine.2021.02.054. Online ahead of print.ABSTRACTThere is existing evidence of a relationship between media use and vaccine hesitancy. Four online questionnaires were completed by general population samples from the US and the UK in June 2020 (N = 1198, N = 3890, N = 1663, N = 2237). After controls, all four studies found a positive association between intention to be vaccinated and usage of broadcast and print media. The three studies which operationalised media usage in terms of frequency found no effect for social media. However, the study which operationalise...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Daniel Allington Siobhan McAndrew Vivienne Louisa Moxham-Hall Bobby Duffy Source Type: research

Joining the herd? U.S. public opinion and vaccination requirements across educational settings during the COVID-19 pandemic
Vaccine. 2021 Mar 23:S0264-410X(21)00348-0. doi: 10.1016/j.vaccine.2021.03.055. Online ahead of print.ABSTRACTWith effective and safe COVID-19 vaccines beginning to be distributed across the United States, questions about who should receive the vaccine first have been the focus of public discussions. Yet, over the long-term, questions about the order of distribution will be displaced by questions about how to achieve high levels of vaccination rates. Historically, absent incentives or mandates, Americans have shown ambivalence, if not general antipathy, towards vaccinations, and vaccination rates have generally been low fo...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Simon F Haeder Source Type: research

Are vaccines against COVID-19 tailored to the most vulnerable people?
Vaccine. 2021 Mar 22:S0264-410X(21)00370-4. doi: 10.1016/j.vaccine.2021.03.066. Online ahead of print.NO ABSTRACTPMID:33810907 | DOI:10.1016/j.vaccine.2021.03.066 (Source: Vaccine)
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Raffaele Antonelli Incalzi Caterina Trevisan Susanna Del Signore Stefano Volpato Stefano Fumagalli Fabio Monzani Giuseppe Bellelli Pietro Gareri Enrico Mossello Alba Malara Alessandra Coin Gianluca Zia Anette Hylen Ranhoff Source Type: research

The safety of BCG revaccination: A systematic review
CONCLUSIONS: Evidence to date suggests that revaccination with BCG vaccine carries minimal risk. Future studies of BCG vaccine for novel applications should report adverse event data stratified by prior BCG vaccination status.PMID:33810902 | DOI:10.1016/j.vaccine.2020.08.016 (Source: Vaccine)
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Samantha Bannister Eva Sudbury Paola Villanueva Kirsten Perrett Nigel Curtis Source Type: research

A retrospective cohort study assessing relative effectiveness of adjuvanted versus high-dose trivalent influenza vaccines among older adults in the United States during the 2018-19 influenza season
Vaccine. 2021 Mar 30:S0264-410X(21)00347-9. doi: 10.1016/j.vaccine.2021.03.054. Online ahead of print.ABSTRACTPURPOSE: To evaluate the relative vaccine effectiveness (rVE) against influenza-related hospitalizations/emergency room (ER) visits, influenza-related office visits, and cardio-respiratory disease (CRD)-related hospitalizations/ER visits and compare all-cause and influenza-related costs associated with two vaccines specifically indicated for older adults (≥65 years), adjuvanted (aTIV) and high-dose trivalent influenza vaccine (TIV-HD), for the 2018-19 influenza season.METHODS: A retrospective analysis of older a...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Stephen I Pelton Victoria Divino Maarten J Postma Drishti Shah Joaquin Mould-Quevedo Mitch DeKoven Girishanthy Krishnarajah Source Type: research

Immunogenicity and safety of sabin-strain based inactivated poliovirus vaccine replacing salk-strain based inactivated poliovirus vaccine: An innovative application of different strain-IPVs replacement
Vaccine. 2021 Mar 30:S0264-410X(21)00264-4. doi: 10.1016/j.vaccine.2021.02.073. Online ahead of print.ABSTRACTBACKGROUND: A domestic Sabin strain-based inactivated poliovirus vaccine (Sabin IPV) was approved by China Food and Drug Administration in 2017 as a replacement for the Salk strain-based inactivated poliovirus vaccine (Salk IPV) that has been in use in China for over 10 years. The present post-marketing trial was implemented in China to assess the immunogenicity and safety of replacing the Salk IPV with the Sabin IPV in the last two immunizations of the standard three-dose schedule.METHODS: We conducted a randomize...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Haiping Chen Zhigang Gao Shuang Bai Xiaoqin Liu Shasha Han Yanhui Xiao Fang Liu Yinghong Yu Hongmei Sun Xiaoming Yang Source Type: research

Media usage predicts intention to be vaccinated against SARS-CoV-2 in the US and the UK
Vaccine. 2021 Mar 16:S0264-410X(21)00234-6. doi: 10.1016/j.vaccine.2021.02.054. Online ahead of print.ABSTRACTThere is existing evidence of a relationship between media use and vaccine hesitancy. Four online questionnaires were completed by general population samples from the US and the UK in June 2020 (N = 1198, N = 3890, N = 1663, N = 2237). After controls, all four studies found a positive association between intention to be vaccinated and usage of broadcast and print media. The three studies which operationalised media usage in terms of frequency found no effect for social media. However, the study which operationalise...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Daniel Allington Siobhan McAndrew Vivienne Louisa Moxham-Hall Bobby Duffy Source Type: research

Joining the herd? U.S. public opinion and vaccination requirements across educational settings during the COVID-19 pandemic
Vaccine. 2021 Mar 23:S0264-410X(21)00348-0. doi: 10.1016/j.vaccine.2021.03.055. Online ahead of print.ABSTRACTWith effective and safe COVID-19 vaccines beginning to be distributed across the United States, questions about who should receive the vaccine first have been the focus of public discussions. Yet, over the long-term, questions about the order of distribution will be displaced by questions about how to achieve high levels of vaccination rates. Historically, absent incentives or mandates, Americans have shown ambivalence, if not general antipathy, towards vaccinations, and vaccination rates have generally been low fo...
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Simon F Haeder Source Type: research

Are vaccines against COVID-19 tailored to the most vulnerable people?
Vaccine. 2021 Mar 22:S0264-410X(21)00370-4. doi: 10.1016/j.vaccine.2021.03.066. Online ahead of print.NO ABSTRACTPMID:33810907 | DOI:10.1016/j.vaccine.2021.03.066 (Source: Vaccine)
Source: Vaccine - April 3, 2021 Category: Allergy & Immunology Authors: Raffaele Antonelli Incalzi Caterina Trevisan Susanna Del Signore Stefano Volpato Stefano Fumagalli Fabio Monzani Giuseppe Bellelli Pietro Gareri Enrico Mossello Alba Malara Alessandra Coin Gianluca Zia Anette Hylen Ranhoff Source Type: research

"You Have to Die Not to Come to Work": A Mixed Methods Study of Attitudes and Behaviors regarding Presenteeism, Absenteeism and Influenza Vaccination among Healthcare Personnel with Respiratory Illness in Israel, 2016-2019
DISCUSSION: Over three influenza seasons in Israel, HCP cited a number of reasons for working while sick, and doubted the usefulness of influenza vaccine. Addressing reasons for presenteeism and vaccine hesitancy among HCP is crucial to protect HCP and patients from influenza virus infection and other viral respiratory illnesses, such as COVID-19.PMID:33789798 | DOI:10.1016/j.vaccine.2021.03.057 (Source: Vaccine)
Source: Vaccine - April 1, 2021 Category: Allergy & Immunology Authors: Rachel Gur-Arie Mark A Katz Avital Hirsch David Greenberg Ryan Malosh Gabriella Newes-Adeyi Nadav Davidovitch Anat Rosenthal Source Type: research

"You Have to Die Not to Come to Work": A Mixed Methods Study of Attitudes and Behaviors regarding Presenteeism, Absenteeism and Influenza Vaccination among Healthcare Personnel with Respiratory Illness in Israel, 2016-2019
DISCUSSION: Over three influenza seasons in Israel, HCP cited a number of reasons for working while sick, and doubted the usefulness of influenza vaccine. Addressing reasons for presenteeism and vaccine hesitancy among HCP is crucial to protect HCP and patients from influenza virus infection and other viral respiratory illnesses, such as COVID-19.PMID:33789798 | DOI:10.1016/j.vaccine.2021.03.057 (Source: Vaccine)
Source: Vaccine - April 1, 2021 Category: Allergy & Immunology Authors: Rachel Gur-Arie Mark A Katz Avital Hirsch David Greenberg Ryan Malosh Gabriella Newes-Adeyi Nadav Davidovitch Anat Rosenthal Source Type: research

"You Have to Die Not to Come to Work": A Mixed Methods Study of Attitudes and Behaviors regarding Presenteeism, Absenteeism and Influenza Vaccination among Healthcare Personnel with Respiratory Illness in Israel, 2016-2019
DISCUSSION: Over three influenza seasons in Israel, HCP cited a number of reasons for working while sick, and doubted the usefulness of influenza vaccine. Addressing reasons for presenteeism and vaccine hesitancy among HCP is crucial to protect HCP and patients from influenza virus infection and other viral respiratory illnesses, such as COVID-19.PMID:33789798 | DOI:10.1016/j.vaccine.2021.03.057 (Source: Vaccine)
Source: Vaccine - April 1, 2021 Category: Allergy & Immunology Authors: Rachel Gur-Arie Mark A Katz Avital Hirsch David Greenberg Ryan Malosh Gabriella Newes-Adeyi Nadav Davidovitch Anat Rosenthal Source Type: research

Safeguarding evidence-based decision making in the FDA for COVID-19 vaccines
Vaccine. 2021 Mar 22:S0264-410X(21)00346-7. doi: 10.1016/j.vaccine.2021.03.053. Online ahead of print.NO ABSTRACTPMID:33785254 | DOI:10.1016/j.vaccine.2021.03.053 (Source: Vaccine)
Source: Vaccine - March 31, 2021 Category: Allergy & Immunology Authors: Aris Angelis Jonathan Darrow Source Type: research

Safeguarding evidence-based decision making in the FDA for COVID-19 vaccines
Vaccine. 2021 Mar 22:S0264-410X(21)00346-7. doi: 10.1016/j.vaccine.2021.03.053. Online ahead of print.NO ABSTRACTPMID:33785254 | DOI:10.1016/j.vaccine.2021.03.053 (Source: Vaccine)
Source: Vaccine - March 31, 2021 Category: Allergy & Immunology Authors: Aris Angelis Jonathan Darrow Source Type: research

Parents' knowledge, beliefs, acceptance and uptake of the HPV vaccine in members of The Association of Southeast Asian Nations (ASEAN): A systematic review of quantitative and qualitative studies
CONCLUSION: Parents' acceptance and uptake of the HPV vaccine in ASEAN member-countries was high when the vaccine was offered for free even though their knowledge of cervical cancer and HPV was poor. Further research is needed to see how uptake and acceptance can be maintain when the vaccine is not offered for free.PMID:33781598 | DOI:10.1016/j.vaccine.2021.03.049 (Source: Vaccine)
Source: Vaccine - March 30, 2021 Category: Allergy & Immunology Authors: Kurnia Eka Wijayanti Heike Sch ütze Catherine MacPhail Annette Braunack-Mayer Source Type: research