Development and characterization of a plant-derived rotavirus-like particle vaccine
CONCLUSIONS: Plant-derived Ro-VLP composed of VP7, VP6 and VP2 structural proteins would be a plausible alternative to live-attenuated oral rotavirus vaccines currently distributed worldwide.PMID:34325930 | DOI:10.1016/j.vaccine.2021.07.039 (Source: Vaccine)
Source: Vaccine - July 30, 2021 Category: Allergy & Immunology Authors: Natsuki Kurokawa Pierre-Olivier Lavoie Marc-Andr é D'Aoust Manon M-J Couture Mich èle Dargis Sonia Tr épanier Shigeki Hoshino Tomohiro Koike Masaaki Arai Naohisa Tsutsui Source Type: research

Effectiveness of a single dose of Japanese encephalitis vaccine among adults, Assam, India, 2012-2018
CONCLUSIONS: A single dose of JE vaccine offered adequate protection for at least six years. Conducting mass vaccination campaigns periodically would further reduce the incidence of JE in endemic districts in Assam.PMID:34325931 | DOI:10.1016/j.vaccine.2021.07.041 (Source: Vaccine)
Source: Vaccine - July 30, 2021 Category: Allergy & Immunology Authors: Siraj A Khan Parveena Choudhury Sanjeeb Kakati Rimamoni Doley Manash P Barman Manoj V Murhekar Harpreet Kaur Source Type: research

COVID-19 vaccine capacity: Challenges and mitigation - The DCVMN perspective
Vaccine. 2021 Jul 13:S0264-410X(21)00866-5. doi: 10.1016/j.vaccine.2021.07.007. Online ahead of print.ABSTRACTVaccine manufacturers from developing countries have a proven track record of developing, producing, and supplying high-quality vaccines globally. However, due to the complexity of vaccine manufacturing, numerous stakeholder organizations support manufacturers across a variety of functions. To optimize the support from stakeholders it is instrumental to first understand which manufacturing processes these manufacturers require support for and what support functions are most beneficial. To this end, the Developing C...
Source: Vaccine - July 30, 2021 Category: Allergy & Immunology Authors: Benoit Hayman Rajinder Suri Sai D Prasad Source Type: research

Does support to Private Health Practitioners increase childhood vaccination coverage? Findings from a comparative study in Afghanistan
Vaccine. 2021 Jul 26:S0264-410X(21)00877-X. doi: 10.1016/j.vaccine.2021.07.018. Online ahead of print.ABSTRACTINTRODUCTION: In Afghanistan coverage of childhood vaccinations is very low, especially in remote and insecure areas with a weak public health structure. Private health providers (PHPs) in these areas play an important role in health care provision, some of whom have received (para)medical training. In 2009 HealthNet TPO initiated a Public-Private Partnership program in Uruzgan province, training and equipping 34 PHPs in remote and conflict-affected locations to provide quality childhood vaccination services. We ai...
Source: Vaccine - July 30, 2021 Category: Allergy & Immunology Authors: Martijn Vink Nawaraj Upadhaya Hazrat Amin Amin Mohammad Gul Liwal Abdul Majeed Siddiqui Mohammad Naseem Aziza Syawash Maarten Schim van der Loeff Source Type: research

Cost-effectiveness of infant respiratory syncytial virus preventive interventions in Mali: A modeling study to inform policy and investment decisions
CONCLUSIONS AND RELEVANCE: In Mali, long-acting monoclonal antibody is likely to be cost-effective from both the government and donor perspectives at $3 per dose. Maternal vaccine would need higher efficacy over that measured by a recent trial in order to be considered cost-effective.PMID:34325934 | DOI:10.1016/j.vaccine.2021.06.086 (Source: Vaccine)
Source: Vaccine - July 30, 2021 Category: Allergy & Immunology Authors: Rachel S Laufer Amanda J Driscoll Ranju Baral Andrea G Buchwald James D Campbell Flanon Coulibaly Fatoumata Diallo Moussa Doumbia Alison P Galvani Fadima C Haidara Karen L Kotloff Adama M Keita Kathleen M Neuzil Evan W Orenstein Lauren A V Orenstein Clint Source Type: research

Cost of vaccine delivery strategies in low- and middle-income countries during the COVID-19 pandemic
CONCLUSIONS: By illustrating potential cost implications of providing immunization services through a range of strategies in a safe manner, these estimates can provide a benchmark for program managers and policy makers on the additional budget required. These findings can help country practitioners and global development partners planning the continuation of immunization services in the context of COVID-19.PMID:34325935 | DOI:10.1016/j.vaccine.2021.06.076 (Source: Vaccine)
Source: Vaccine - July 30, 2021 Category: Allergy & Immunology Authors: Christina Banks Allison Portnoy Flavia Moi Laura Boonstoppel Logan Brenzel Stephen C Resch Source Type: research

Playing vaccine roulette: Why the current strategy of staking everything on Covid-19 vaccines is a high-stakes wager
Vaccine. 2021 Jul 20:S0264-410X(21)00923-3. doi: 10.1016/j.vaccine.2021.07.045. Online ahead of print.NO ABSTRACTPMID:34315610 | PMC:PMC8289694 | DOI:10.1016/j.vaccine.2021.07.045 (Source: Vaccine)
Source: Vaccine - July 28, 2021 Category: Allergy & Immunology Authors: Elisabeth Paul Garrett W Brown Andreas Kalk Val éry Ridde Source Type: research

A phase 3, randomized, double-blind study to evaluate the immunogenicity and safety of 3 lots of 20-valent pneumococcal conjugate vaccine in pneumococcal vaccine-naive adults 18 through 49 years of age
CONCLUSIONS: Three different lots of PCV20 demonstrated robust and consistent immunogenicity. The safety and tolerability of PCV20 was acceptable and similar to that of PCV13. (Clinicaltrials.gov: NCT03828617).PMID:34315611 | DOI:10.1016/j.vaccine.2021.07.004 (Source: Vaccine)
Source: Vaccine - July 28, 2021 Category: Allergy & Immunology Authors: Nicola P Klein Paula Peyrani Kari Yacisin Nicole Caldwell Xia Xu Ingrid L Scully Daniel A Scott Kathrin U Jansen William C Gruber Wendy Watson Source Type: research

Playing vaccine roulette: Why the current strategy of staking everything on Covid-19 vaccines is a high-stakes wager
Vaccine. 2021 Jul 20:S0264-410X(21)00923-3. doi: 10.1016/j.vaccine.2021.07.045. Online ahead of print.NO ABSTRACTPMID:34315610 | DOI:10.1016/j.vaccine.2021.07.045 (Source: Vaccine)
Source: Vaccine - July 28, 2021 Category: Allergy & Immunology Authors: Elisabeth Paul Garrett W Brown Andreas Kalk Val éry Ridde Source Type: research

A phase 3, randomized, double-blind study to evaluate the immunogenicity and safety of 3 lots of 20-valent pneumococcal conjugate vaccine in pneumococcal vaccine-naive adults 18 through 49 years of age
CONCLUSIONS: Three different lots of PCV20 demonstrated robust and consistent immunogenicity. The safety and tolerability of PCV20 was acceptable and similar to that of PCV13. (Clinicaltrials.gov: NCT03828617).PMID:34315611 | DOI:10.1016/j.vaccine.2021.07.004 (Source: Vaccine)
Source: Vaccine - July 28, 2021 Category: Allergy & Immunology Authors: Nicola P Klein Paula Peyrani Kari Yacisin Nicole Caldwell Xia Xu Ingrid L Scully Daniel A Scott Kathrin U Jansen William C Gruber Wendy Watson Source Type: research

Clostridium septicum: A review in the light of alpha-toxin and development of vaccines
Vaccine. 2021 Jul 23:S0264-410X(21)00878-1. doi: 10.1016/j.vaccine.2021.07.019. Online ahead of print.ABSTRACTClostridium septicum (CS) is a pathogen that can cause the death of animals in livestock worldwide through its main virulence factor, alpha-toxin (ATX). The aspects involved in diseases caused by ATX, such as economic impact, prevalence, and rapid clinical course, require that animals should be systematically immunized. This review provides an overview of CS in livestock farming and discusses current immunization methods. Currently, commercial vaccines available against CS involve the cultivation and inactivation o...
Source: Vaccine - July 27, 2021 Category: Allergy & Immunology Authors: Mariliana Luiza Ferreira Alves Marcos Roberto Alves Ferreira Rafael Amaral Donassolo Rafael Rodrigues Rodrigues Fabricio Rochedo Concei ção Source Type: research

Racial disparities in influenza immunization during pregnancy in the United States: A narrative review of the evidence for disparities and potential interventions
CONCLUSIONS: Racial disparities in maternal uptake of the influenza vaccine are long-standing, but not intractable. More research is needed to test interventions to address this disparity, with a focus on increasing provider recommendation and offer of the vaccine, addressing patients' concerns about vaccine safety and efficacy, improving providers' cultural competence, and building trust between providers and patients.PMID:34312009 | DOI:10.1016/j.vaccine.2021.07.028 (Source: Vaccine)
Source: Vaccine - July 27, 2021 Category: Allergy & Immunology Authors: Alice G Callahan Victoria H Coleman-Cowger Jay Schulkin Michael L Power Source Type: research

The Novel Platform of mRNA COVID-19 Vaccines and Myocarditis: Clues into the Potential Underlying Mechanism
Vaccine. 2021 Jul 13:S0264-410X(21)00875-6. doi: 10.1016/j.vaccine.2021.07.016. Online ahead of print.NO ABSTRACTPMID:34312010 | PMC:PMC8275472 | DOI:10.1016/j.vaccine.2021.07.016 (Source: Vaccine)
Source: Vaccine - July 27, 2021 Category: Allergy & Immunology Authors: George Lazaros Allan L Klein Sophia Hatziantoniou Costas Tsioufis Athanasios Tsakris Cleo Anastassopoulou Source Type: research

Clostridium septicum: A review in the light of alpha-toxin and development of vaccines
Vaccine. 2021 Jul 23:S0264-410X(21)00878-1. doi: 10.1016/j.vaccine.2021.07.019. Online ahead of print.ABSTRACTClostridium septicum (CS) is a pathogen that can cause the death of animals in livestock worldwide through its main virulence factor, alpha-toxin (ATX). The aspects involved in diseases caused by ATX, such as economic impact, prevalence, and rapid clinical course, require that animals should be systematically immunized. This review provides an overview of CS in livestock farming and discusses current immunization methods. Currently, commercial vaccines available against CS involve the cultivation and inactivation o...
Source: Vaccine - July 27, 2021 Category: Allergy & Immunology Authors: Mariliana Luiza Ferreira Alves Marcos Roberto Alves Ferreira Rafael Amaral Donassolo Rafael Rodrigues Rodrigues Fabricio Rochedo Concei ção Source Type: research

Racial disparities in influenza immunization during pregnancy in the United States: A narrative review of the evidence for disparities and potential interventions
CONCLUSIONS: Racial disparities in maternal uptake of the influenza vaccine are long-standing, but not intractable. More research is needed to test interventions to address this disparity, with a focus on increasing provider recommendation and offer of the vaccine, addressing patients' concerns about vaccine safety and efficacy, improving providers' cultural competence, and building trust between providers and patients.PMID:34312009 | DOI:10.1016/j.vaccine.2021.07.028 (Source: Vaccine)
Source: Vaccine - July 27, 2021 Category: Allergy & Immunology Authors: Alice G Callahan Victoria H Coleman-Cowger Jay Schulkin Michael L Power Source Type: research

The Novel Platform of mRNA COVID-19 Vaccines and Myocarditis: Clues into the Potential Underlying Mechanism
Vaccine. 2021 Jul 13:S0264-410X(21)00875-6. doi: 10.1016/j.vaccine.2021.07.016. Online ahead of print.NO ABSTRACTPMID:34312010 | DOI:10.1016/j.vaccine.2021.07.016 (Source: Vaccine)
Source: Vaccine - July 27, 2021 Category: Allergy & Immunology Authors: George Lazaros Allan L Klein Sophia Hatziantoniou Costas Tsioufis Athanasios Tsakris Cleo Anastassopoulou Source Type: research

An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity
Vaccine. 2021 Jul 16:S0264-410X(21)00911-7. doi: 10.1016/j.vaccine.2021.07.034. Online ahead of print.ABSTRACTWe evaluated enveloped virus-like particles (eVLPs) expressing various forms of the Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein and several adjuvants in an effort to identify a highly potent Coronavirus disease 2019 (COVID-19) vaccine candidate. eVLPs expressing a modified prefusion form of SARS-CoV-2 spike protein were selected as they induced high antibody binding titers and neutralizing activity after a single injection in mice. Formulation of SARS-CoV-2 S eVLPs with aluminum phosp...
Source: Vaccine - July 26, 2021 Category: Allergy & Immunology Authors: Anne-Catherine Fluckiger Barthelemy Ontsouka Jasminka Bozic Abebaw Diress Tanvir Ahmed Tamara Berthoud Anh Tran Diane Duque Mingmin Liao Michael McCluskie Francisco Diaz-Mitoma David E Anderson Catalina Soare Source Type: research

Burden of pneumonia in patients with viral and bacterial coinfection in Spain during six consecutive influenza seasons, from 2009-10 to 2014-15
CONCLUSIONS: In Spain, community-acquired pneumonia and influenza continue to be an important cause of hospitalization and mortality in patients over 60 years of age. There is an urgent need to further develop prevention strategies such as joint vaccination for both pathologies.PMID:34304929 | DOI:10.1016/j.vaccine.2021.07.035 (Source: Vaccine)
Source: Vaccine - July 26, 2021 Category: Allergy & Immunology Authors: Loreto Arias-Fern ández Jes ús San-Román Montero Ruth Gil-Prieto Stefan Walter Ángel Gil de Miguel Source Type: research

An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits highly potent immunity
Vaccine. 2021 Jul 16:S0264-410X(21)00911-7. doi: 10.1016/j.vaccine.2021.07.034. Online ahead of print.ABSTRACTWe evaluated enveloped virus-like particles (eVLPs) expressing various forms of the Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein and several adjuvants in an effort to identify a highly potent Coronavirus disease 2019 (COVID-19) vaccine candidate. eVLPs expressing a modified prefusion form of SARS-CoV-2 spike protein were selected as they induced high antibody binding titers and neutralizing activity after a single injection in mice. Formulation of SARS-CoV-2 S eVLPs with aluminum phosp...
Source: Vaccine - July 26, 2021 Category: Allergy & Immunology Authors: Anne-Catherine Fluckiger Barthelemy Ontsouka Jasminka Bozic Abebaw Diress Tanvir Ahmed Tamara Berthoud Anh Tran Diane Duque Mingmin Liao Michael McCluskie Francisco Diaz-Mitoma David E Anderson Catalina Soare Source Type: research

Burden of pneumonia in patients with viral and bacterial coinfection in Spain during six consecutive influenza seasons, from 2009-10 to 2014-15
CONCLUSIONS: In Spain, community-acquired pneumonia and influenza continue to be an important cause of hospitalization and mortality in patients over 60 years of age. There is an urgent need to further develop prevention strategies such as joint vaccination for both pathologies.PMID:34304929 | DOI:10.1016/j.vaccine.2021.07.035 (Source: Vaccine)
Source: Vaccine - July 26, 2021 Category: Allergy & Immunology Authors: Loreto Arias-Fern ández Jes ús San-Román Montero Ruth Gil-Prieto Stefan Walter Ángel Gil de Miguel Source Type: research

Vitamin D supplementation: An alternative to enhance the effectiveness of vaccines against SARS-CoV-2?
Vaccine. 2021 Jul 16:S0264-410X(21)00908-7. doi: 10.1016/j.vaccine.2021.07.031. Online ahead of print.NO ABSTRACTPMID:34303561 | DOI:10.1016/j.vaccine.2021.07.031 (Source: Vaccine)
Source: Vaccine - July 25, 2021 Category: Allergy & Immunology Authors: Felipe Inserra Carlos Tajer Laura Antonietti Javier Mariani Le ón Ferder Walter Manucha Source Type: research

The selection of naturally stable candidate foot-and-mouth disease virus vaccine strains for East Africa
Vaccine. 2021 Jul 21:S0264-410X(21)00860-4. doi: 10.1016/j.vaccine.2021.07.001. Online ahead of print.ABSTRACTFoot-and-mouth disease (FMD) is a global burden on the livestock industry. The causative agent, FMD virus (FMDV), is highly infectious and exists in seven distinct serotypes. Vaccination remains the most effective control strategy in endemic regions and current FMD vaccines are made from inactivated preparations of whole virus. The inherent instability of FMDV and the emergence of new strains presents challenges to efficacious vaccine development. Currently, vaccines available in East Africa are comprised of relati...
Source: Vaccine - July 25, 2021 Category: Allergy & Immunology Authors: Ben Jackson Yongjie Harvey Eva Perez-Martin Ginette Wilsden Nicholas Juleff Bryan Charleston Julian Seago Source Type: research

The projected cost-effectiveness and budget impact of HPV vaccine introduction in Ghana
This study projected the cost-effectiveness and budget impact of adding HPV vaccination into Ghana's national immunization program.METHODS: We used a proportional outcomes model (UNIVAC, version 1.4) to evaluate the cost-effectiveness of introduction with bivalent (Cervarix™) and quadrivalent (Gardasil®) vaccines from government and societal perspectives. Vaccine introduction was modeled to start in 2022 and continue over ten birth cohorts using a combined delivery strategy of school (80%) and community outreach (20%). We modeled vaccination in a single age cohort of 9-year-old girls vs. a multi-age cohort of 9-y...
Source: Vaccine - July 25, 2021 Category: Allergy & Immunology Authors: Elisabeth Vodicka Justice Nonvignon Kwadwo Odei Antwi-Agyei John Bawa Andrew Clark Clint Pecenka D Scott LaMontagne Source Type: research

Using genomics to examine the persistence of Streptococcus pneumoniae serotype 19A in Ireland and the emergence of a sub-clade associated with vaccine failures
Vaccine. 2021 Jul 20:S0264-410X(21)00741-6. doi: 10.1016/j.vaccine.2021.06.017. Online ahead of print.ABSTRACTBACKGROUND: Streptococcus pneumoniae serotype 19A remains a significant cause of invasive pneumococcal disease (IPD) in Ireland despite the successful introduction of a 13-valent pneumococcal conjugate vaccine (PCV13) in 2010 which reduced the overall incidence of IPD in children.METHODS: Invasive Streptococcus pneumoniae serotype 19A isolates from the Irish reference laboratory between 2007-08 and 2017-18 were analysed using whole genome sequencing (WGS) to investigate the persistence of this vaccine-preventable s...
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: M Corcoran J Mereckiene S Cotter S Murchan S W Lo L McGee R F Breiman R Cunney H Humphreys S D Bentley R A Gladstone Source Type: research

M2e conjugated gold nanoparticle influenza vaccine displays thermal stability at elevated temperatures and confers protection to ferrets
In this study, we show that the vaccine is thermally stable when stored at 4 °C for 3 months, 37 °C for 3 months and 50 °C for 2 weeks in its lyophilized form, and later it was possible to readily reconstitute it in water without aggregation. Intranasal vaccination of mice using reconstituted vaccine induced M2e-specific IgG and IgG subtypes in serum similar to the freshly formulated vaccine, and fully protected mice against lethal influenza A challenge. Immunization of ferrets intranasally or intramuscularly with the vaccine induced M2e-specific IgG and there was reduced virus level in nasal wash of ferrets im...
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: Rohan S J Ingrole Wenqian Tao Gaurav Joshi Harvinder Singh Gill Source Type: research

Bacillus Calmette-Guerin (BCG) vaccination to treat endometriosis
Vaccine. 2021 Jul 20:S0264-410X(21)00879-3. doi: 10.1016/j.vaccine.2021.07.020. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG), a vaccine intended to protect against tuberculosis disease, can elicit protection against heterologous infections, and even specific types of cancer. In this mini-review, we will address the possible use of BCG as a therapeutic for endometriosis, a syndrome of chronic pelvic pain due to ectopic growth of endometrial-type tissue outside of the uterine lining. These implanted tissues cycle synchronously with menses in pre-menopausal women, generating cellular debris inciting chro...
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: Jonathan Hecht Sara Suliman Barbara Wegiel Source Type: research

Influenza vaccine effectiveness against influenza-associated hospitalization in children in Hong Kong, 2010-2020
CONCLUSIONS: The childhood influenza vaccination program in Hong Kong has prevented influenza-associated hospitalizations particularly in younger children. Our findings support the use of influenza vaccines in children as an effective approach to influenza control and prevention.PMID:34301433 | DOI:10.1016/j.vaccine.2021.07.014 (Source: Vaccine)
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: Huiying Chua Mike Y W Kwan Eunice L Y Chan Joshua S C Wong J S Malik Peiris Benjamin J Cowling Susan S Chiu Source Type: research

Using genomics to examine the persistence of Streptococcus pneumoniae serotype 19A in Ireland and the emergence of a sub-clade associated with vaccine failures
Vaccine. 2021 Jul 20:S0264-410X(21)00741-6. doi: 10.1016/j.vaccine.2021.06.017. Online ahead of print.ABSTRACTBACKGROUND: Streptococcus pneumoniae serotype 19A remains a significant cause of invasive pneumococcal disease (IPD) in Ireland despite the successful introduction of a 13-valent pneumococcal conjugate vaccine (PCV13) in 2010 which reduced the overall incidence of IPD in children.METHODS: Invasive Streptococcus pneumoniae serotype 19A isolates from the Irish reference laboratory between 2007-08 and 2017-18 were analysed using whole genome sequencing (WGS) to investigate the persistence of this vaccine-preventable s...
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: M Corcoran J Mereckiene S Cotter S Murchan S W Lo L McGee R F Breiman R Cunney H Humphreys S D Bentley R A Gladstone Source Type: research

M2e conjugated gold nanoparticle influenza vaccine displays thermal stability at elevated temperatures and confers protection to ferrets
In this study, we show that the vaccine is thermally stable when stored at 4 °C for 3 months, 37 °C for 3 months and 50 °C for 2 weeks in its lyophilized form, and later it was possible to readily reconstitute it in water without aggregation. Intranasal vaccination of mice using reconstituted vaccine induced M2e-specific IgG and IgG subtypes in serum similar to the freshly formulated vaccine, and fully protected mice against lethal influenza A challenge. Immunization of ferrets intranasally or intramuscularly with the vaccine induced M2e-specific IgG and there was reduced virus level in nasal wash of ferrets im...
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: Rohan S J Ingrole Wenqian Tao Gaurav Joshi Harvinder Singh Gill Source Type: research

Bacillus Calmette-Guerin (BCG) vaccination to treat endometriosis
Vaccine. 2021 Jul 20:S0264-410X(21)00879-3. doi: 10.1016/j.vaccine.2021.07.020. Online ahead of print.ABSTRACTBacille Calmette-Guérin (BCG), a vaccine intended to protect against tuberculosis disease, can elicit protection against heterologous infections, and even specific types of cancer. In this mini-review, we will address the possible use of BCG as a therapeutic for endometriosis, a syndrome of chronic pelvic pain due to ectopic growth of endometrial-type tissue outside of the uterine lining. These implanted tissues cycle synchronously with menses in pre-menopausal women, generating cellular debris inciting chro...
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: Jonathan Hecht Sara Suliman Barbara Wegiel Source Type: research

Influenza vaccine effectiveness against influenza-associated hospitalization in children in Hong Kong, 2010-2020
CONCLUSIONS: The childhood influenza vaccination program in Hong Kong has prevented influenza-associated hospitalizations particularly in younger children. Our findings support the use of influenza vaccines in children as an effective approach to influenza control and prevention.PMID:34301433 | DOI:10.1016/j.vaccine.2021.07.014 (Source: Vaccine)
Source: Vaccine - July 24, 2021 Category: Allergy & Immunology Authors: Huiying Chua Mike Y W Kwan Eunice L Y Chan Joshua S C Wong J S Malik Peiris Benjamin J Cowling Susan S Chiu Source Type: research

Longitudinal assessment of nonavalent vaccine HPV types in a sample of sexually active African American women from ten U.S. Cities
CONCLUSIONS: Our findings suggest that HPV vaccination which is currently recommended for all unvaccinated persons through age 26 years, is likely to be more beneficial than previously thought as nonavalent HPV vaccine was not available during the time these data were collected.PMID:34294478 | DOI:10.1016/j.vaccine.2021.07.026 (Source: Vaccine)
Source: Vaccine - July 23, 2021 Category: Allergy & Immunology Authors: P Madhivanan K Krupp M Coudray B Colbert D Ruiz-Perez H Cui N Bokulich G Narasimhan K Mathee R L Cook J Schwebke D Roe Source Type: research

Induction of an effective anti-Amyloid- β humoral response in aged mice
Vaccine. 2021 Jul 19:S0264-410X(21)00882-3. doi: 10.1016/j.vaccine.2021.07.023. Online ahead of print.ABSTRACTAging-related decline in immune functions, termed immunosenescence, is a primary cause of reduced protective responses to vaccines in the elderly, due to impaired induction of cellular and humoral responses to new antigens (Ag), especially if the response is T cell dependent. The result is a more severe morbidity following infections, more prolonged and frequent hospitalization, and a higher mortality rate than in the general population. Therefore, there is an increasing need to develop vaccination strategies that ...
Source: Vaccine - July 23, 2021 Category: Allergy & Immunology Authors: Tomer Illouz Ravit Madar Tamir Hirsh Arya Biragyn Eitan Okun Source Type: research

Long-term survivors following autologous haematopoetic stem cell transplantation have significant defects in their humoral immunity against vaccine preventable diseases, years on from transplant
Vaccine. 2021 Jul 19:S0264-410X(21)00881-1. doi: 10.1016/j.vaccine.2021.07.022. Online ahead of print.ABSTRACTCurrent international guidelines recommend routinely vaccinating haematopoetic stem cell transplant (HSCT) recipients. Despite significant infection-related mortality following autologous HSCT, routine vaccination programmes (RVP) completion is poor. For recovered HSCT recipients, it is uncertain whether catch-up vaccination remains worthwhile years later. To determine potential susceptibility to vaccine preventable infections, we measured antibody titres in 56 patients, a median of 7 years (range 0-29) following a...
Source: Vaccine - July 23, 2021 Category: Allergy & Immunology Authors: Hayley Colton Diana M Greenfield John A Snowden Paul D E Miller Nicholas J Morley Josh Wright Thomas C Darton Cariad M Evans Thushan I de Silva Source Type: research

Longitudinal assessment of nonavalent vaccine HPV types in a sample of sexually active African American women from ten U.S. Cities
CONCLUSIONS: Our findings suggest that HPV vaccination which is currently recommended for all unvaccinated persons through age 26 years, is likely to be more beneficial than previously thought as nonavalent HPV vaccine was not available during the time these data were collected.PMID:34294478 | DOI:10.1016/j.vaccine.2021.07.026 (Source: Vaccine)
Source: Vaccine - July 23, 2021 Category: Allergy & Immunology Authors: P Madhivanan K Krupp M Coudray B Colbert D Ruiz-Perez H Cui N Bokulich G Narasimhan K Mathee R L Cook J Schwebke D Roe Source Type: research

Induction of an effective anti-Amyloid- β humoral response in aged mice
Vaccine. 2021 Jul 19:S0264-410X(21)00882-3. doi: 10.1016/j.vaccine.2021.07.023. Online ahead of print.ABSTRACTAging-related decline in immune functions, termed immunosenescence, is a primary cause of reduced protective responses to vaccines in the elderly, due to impaired induction of cellular and humoral responses to new antigens (Ag), especially if the response is T cell dependent. The result is a more severe morbidity following infections, more prolonged and frequent hospitalization, and a higher mortality rate than in the general population. Therefore, there is an increasing need to develop vaccination strategies that ...
Source: Vaccine - July 23, 2021 Category: Allergy & Immunology Authors: Tomer Illouz Ravit Madar Tamir Hirsh Arya Biragyn Eitan Okun Source Type: research

Long-term survivors following autologous haematopoetic stem cell transplantation have significant defects in their humoral immunity against vaccine preventable diseases, years on from transplant
Vaccine. 2021 Jul 19:S0264-410X(21)00881-1. doi: 10.1016/j.vaccine.2021.07.022. Online ahead of print.ABSTRACTCurrent international guidelines recommend routinely vaccinating haematopoetic stem cell transplant (HSCT) recipients. Despite significant infection-related mortality following autologous HSCT, routine vaccination programmes (RVP) completion is poor. For recovered HSCT recipients, it is uncertain whether catch-up vaccination remains worthwhile years later. To determine potential susceptibility to vaccine preventable infections, we measured antibody titres in 56 patients, a median of 7 years (range 0-29) following a...
Source: Vaccine - July 23, 2021 Category: Allergy & Immunology Authors: Hayley Colton Diana M Greenfield John A Snowden Paul D E Miller Nicholas J Morley Josh Wright Thomas C Darton Cariad M Evans Thushan I de Silva Source Type: research

Vaccinating Australia: How long will it take?
Vaccine. 2021 Jul 17:S0264-410X(21)00865-3. doi: 10.1016/j.vaccine.2021.07.006. Online ahead of print.ABSTRACTThe Australian Government began to roll out the national COVID-19 vaccination program in late February 2021, with the initial aim to vaccinate the Australian adult population by the end of October 2021. The task of vaccinating some 20 million people presents considerable logistic challenges, but a rapid rollout is essential to allow for the reopening of borders and is especially urgent as new more transmissible variants arise. Here, we run a series of projections to estimate how long it will take to vaccinate the A...
Source: Vaccine - July 21, 2021 Category: Allergy & Immunology Authors: Mark Hanly Timothy Churches Ois ín Fitzgerald C Raina MacIntyre Louisa Jorm Source Type: research

Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope
Vaccine. 2021 Jul 17:S0264-410X(21)00880-X. doi: 10.1016/j.vaccine.2021.07.021. Online ahead of print.ABSTRACTHuman ferritin heavy chain, an example of a protein nanoparticle, has recently been used as a vaccine delivery platform. Human ferritin has advantages of uniform architecture, robust thermal and chemical stabilities, and good biocompatibility and biodegradation. There is however a lack of understanding about the relationship between insertion sites in ferritin (N-terminus and C-terminus) and the corresponding humoral and cell-mediated immune responses. To bridge this gap, we utilized an Epstein-Barr Nuclear Antigen...
Source: Vaccine - July 21, 2021 Category: Allergy & Immunology Authors: Yiran Qu Bingyang Zhang Yingli Wang Shuang Yin Jordan L Pederick John B Bruning Yan Sun Anton Middelberg Jingxiu Bi Source Type: research

Vaccinating Australia: How long will it take?
Vaccine. 2021 Jul 17:S0264-410X(21)00865-3. doi: 10.1016/j.vaccine.2021.07.006. Online ahead of print.ABSTRACTThe Australian Government began to roll out the national COVID-19 vaccination program in late February 2021, with the initial aim to vaccinate the Australian adult population by the end of October 2021. The task of vaccinating some 20 million people presents considerable logistic challenges, but a rapid rollout is essential to allow for the reopening of borders and is especially urgent as new more transmissible variants arise. Here, we run a series of projections to estimate how long it will take to vaccinate the A...
Source: Vaccine - July 21, 2021 Category: Allergy & Immunology Authors: Mark Hanly Timothy Churches Ois ín Fitzgerald C Raina MacIntyre Louisa Jorm Source Type: research

Immunogenicity study of engineered ferritins with C- and N-terminus insertion of Epstein-Barr nuclear antigen 1 epitope
Vaccine. 2021 Jul 17:S0264-410X(21)00880-X. doi: 10.1016/j.vaccine.2021.07.021. Online ahead of print.ABSTRACTHuman ferritin heavy chain, an example of a protein nanoparticle, has recently been used as a vaccine delivery platform. Human ferritin has advantages of uniform architecture, robust thermal and chemical stabilities, and good biocompatibility and biodegradation. There is however a lack of understanding about the relationship between insertion sites in ferritin (N-terminus and C-terminus) and the corresponding humoral and cell-mediated immune responses. To bridge this gap, we utilized an Epstein-Barr Nuclear Antigen...
Source: Vaccine - July 21, 2021 Category: Allergy & Immunology Authors: Yiran Qu Bingyang Zhang Yingli Wang Shuang Yin Jordan L Pederick John B Bruning Yan Sun Anton Middelberg Jingxiu Bi Source Type: research

COVID-19 vaccine roll-out in middle-income countries: Lessons learned from the Jordan experience
Vaccine. 2021 Jun 29:S0264-410X(21)00840-9. doi: 10.1016/j.vaccine.2021.06.078. Online ahead of print.NO ABSTRACTPMID:34281741 | PMC:PMC8238651 | DOI:10.1016/j.vaccine.2021.06.078 (Source: Vaccine)
Source: Vaccine - July 20, 2021 Category: Allergy & Immunology Authors: Ala'a Al-Shaikh Nazeema Muthu Chinara Aidyralieva Maria Cristina Profili Saverio Bellizzi Source Type: research

Marketing the COVID-19 vaccine and the implications for public health
Vaccine. 2021 Jul 13:S0264-410X(21)00874-4. doi: 10.1016/j.vaccine.2021.07.015. Online ahead of print.ABSTRACTCOVID-19 vaccines are new brands of consumer health technology being introduced to the market. Considering consumer behaviour approaches in this time of crisis, the risk of vaccine hesitancy, the call for more transparency and effective messaging to gain trust, and equitable distribution of this vaccine, this is unexplored theoretical terrain. This commentary takes a multidisciplinary approach to understand and theoretically explore the marketing, distribution, and acceptance of the COVID-19 vaccine. The paper inte...
Source: Vaccine - July 20, 2021 Category: Allergy & Immunology Authors: Emmanuel Mogaji Source Type: research

Human papillomavirus prevalence and risk factors among Australian women 9-12  years after vaccine program introduction
Vaccine. 2021 Jul 16:S0264-410X(21)00864-1. doi: 10.1016/j.vaccine.2021.07.005. Online ahead of print.ABSTRACTBACKGROUND: In Australia, high and widespread uptake of the quadrivalent human papillomavirus (HPV) vaccine has led to substantial population-level reductions in the prevalence of quadrivalent vaccine targeted HPV genotypes 6/11/16/18 in women aged ≤ 35 years. We assessed risk factors for HPV detection among 18-35 year old women, 9-12 years after vaccine program introduction.METHODS: Women attending health services between 2015 and 2018 provided a self-collected vaginal specimen for HPV genotyping (Roche Linear ...
Source: Vaccine - July 20, 2021 Category: Allergy & Immunology Authors: Hannah Shilling Suzanne M Garland Steph Atchison Alyssa M Cornall Julia M L Brotherton Deborah Bateson Kathleen McNamee John M Kaldor Jane S Hocking Marcus Y Chen Christopher K Fairley Anna McNulty Charlotte Bell Lewis Marshall Catriona Ooi S Rachel Skinn Source Type: research

COVID-19 vaccine roll-out in middle-income countries: Lessons learned from the Jordan experience
Vaccine. 2021 Jun 29:S0264-410X(21)00840-9. doi: 10.1016/j.vaccine.2021.06.078. Online ahead of print.NO ABSTRACTPMID:34281741 | DOI:10.1016/j.vaccine.2021.06.078 (Source: Vaccine)
Source: Vaccine - July 20, 2021 Category: Allergy & Immunology Authors: Ala'a Al-Shaikh Nazeema Muthu Chinara Aidyralieva Maria Cristina Profili Saverio Bellizzi Source Type: research

Marketing the COVID-19 vaccine and the implications for public health
Vaccine. 2021 Jul 13:S0264-410X(21)00874-4. doi: 10.1016/j.vaccine.2021.07.015. Online ahead of print.ABSTRACTCOVID-19 vaccines are new brands of consumer health technology being introduced to the market. Considering consumer behaviour approaches in this time of crisis, the risk of vaccine hesitancy, the call for more transparency and effective messaging to gain trust, and equitable distribution of this vaccine, this is unexplored theoretical terrain. This commentary takes a multidisciplinary approach to understand and theoretically explore the marketing, distribution, and acceptance of the COVID-19 vaccine. The paper inte...
Source: Vaccine - July 20, 2021 Category: Allergy & Immunology Authors: Emmanuel Mogaji Source Type: research

Human papillomavirus prevalence and risk factors among Australian women 9-12  years after vaccine program introduction
Vaccine. 2021 Jul 16:S0264-410X(21)00864-1. doi: 10.1016/j.vaccine.2021.07.005. Online ahead of print.ABSTRACTBACKGROUND: In Australia, high and widespread uptake of the quadrivalent human papillomavirus (HPV) vaccine has led to substantial population-level reductions in the prevalence of quadrivalent vaccine targeted HPV genotypes 6/11/16/18 in women aged ≤ 35 years. We assessed risk factors for HPV detection among 18-35 year old women, 9-12 years after vaccine program introduction.METHODS: Women attending health services between 2015 and 2018 provided a self-collected vaginal specimen for HPV genotyping (Roche Linear ...
Source: Vaccine - July 20, 2021 Category: Allergy & Immunology Authors: Hannah Shilling Suzanne M Garland Steph Atchison Alyssa M Cornall Julia M L Brotherton Deborah Bateson Kathleen McNamee John M Kaldor Jane S Hocking Marcus Y Chen Christopher K Fairley Anna McNulty Charlotte Bell Lewis Marshall Catriona Ooi S Rachel Skinn Source Type: research

Inadequate deltoid muscle penetration and concerns of improper COVID mRNA vaccine administration can be avoided by injection technique modification
CONCLUSIONS: Skin bunching will prevent adequate intramuscular injection of vaccines in a small percentage of persons, but as hundreds of millions are expected to receive mRNA vaccines in the coming months, the multiplied result can have significant personal and societal consequences for millions of people globally, especially in obese populations, and therefore this practice should be strictly discouraged.PMID:34275671 | DOI:10.1016/j.vaccine.2021.06.081 (Source: Vaccine)
Source: Vaccine - July 19, 2021 Category: Allergy & Immunology Authors: Nimrod Rahamimov Veronica Baturov Adi Shani Ilai Ben Zoor Doron Fischer Anna Chernihovsky Source Type: research

Disproportionality analysis of reported drug adverse events to assess a potential safety signal for pentavalent vaccine in 2019 in El Salvador
Vaccine. 2021 Jul 15:S0264-410X(21)00869-0. doi: 10.1016/j.vaccine.2021.07.010. Online ahead of print.ABSTRACTDetection and surveillance of vaccine safety hazards is a public health staple. In the post-marketing phase, when vaccines are used in mass, it is crucial to monitor potential signals of adverse reactions that may have been missed in the pre-marketing phase. We analysed spontaneous reports of drug adverse events in El Salvador to assess a potential safety signal related to an increase in febrile seizures following the pentavalent (diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae Type B) vacci...
Source: Vaccine - July 19, 2021 Category: Allergy & Immunology Authors: Miguel Elas Nora Villatoro Lorenzo Pezzoli Source Type: research

Improving supervision practices in resource-limited settings: Opportunities to sustain short-term gains from external technical support
Vaccine. 2021 Jul 15:S0264-410X(21)00814-8. doi: 10.1016/j.vaccine.2021.06.064. Online ahead of print.NO ABSTRACTPMID:34275673 | DOI:10.1016/j.vaccine.2021.06.064 (Source: Vaccine)
Source: Vaccine - July 19, 2021 Category: Allergy & Immunology Authors: Debora Weiss Hardeep Sandhu Monica Fleming Chung-Won Lee Source Type: research