Completion of the two-dose recombinant zoster vaccine series in adults 50 years and older.
CONCLUSION: Completion of RZV series appears suboptimal in the early phase of implementation. Despite similar accessibility in a health care system, completion varied by race/ethnicity, socioeconomic status, health status, and care seeking behavior, suggesting areas to target for improvement. PMID: 33441234 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 11, 2021 Category: Allergy & Immunology Authors: Ackerson B, Qian L, Sy LS, Bruxvoort K, Wu J, Luo Y, Diaz-Decaro J, Talarico C, Tseng HF Tags: Vaccine Source Type: research

Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies.
PC Abstract Neonatal passive immunity, derived from transplacental transfer of IgG antibodies from mother to fetus during pregnancy, can mitigate the risk for severe infections in the early postnatal period. Understanding the placenta as the gateway organ in this process, we aimed to evaluate the influence of specific factors modulating the transplacental IgG transfer rate (TPTR) in 141 mother/neonate pairs. We further evaluated the potential health advantage elicited by maternal IgG with regard to respiratory tract infections during infancy and early childhood. Data and biological samples collected within the pr...
Source: Vaccine - January 8, 2021 Category: Allergy & Immunology Authors: Albrecht M, Pagenkemper M, Wiessner C, Spohn M, Lütgehetmann M, Jacobsen H, Gabriel G, Zazara DE, Haertel C, Hecher K, Diemert A, Arck PC Tags: Vaccine Source Type: research

Vaccine coverage in children born to migrant mothers in Australia: A population-based cohort study.
CONCLUSIONS: On-time vaccination rates differed by mother's region of birth. More research is needed to determine the main reasons for these remaining differences to improve vaccine uptake and also help guide policy and practice. PMID: 33431224 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 8, 2021 Category: Allergy & Immunology Authors: Abdi I, Gidding H, Leong RN, Moore HC, Seale H, Menzies R Tags: Vaccine Source Type: research

Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine.
Abstract The circumsporozoite protein (CSP) is the main surface antigen of malaria sporozoites, a prime vaccine target, and is known to have polymorphisms in the C-terminal region. Vaccines using a single allele may have lower efficacy against genotypic variants. Recent studies have found evidence suggesting the efficacy of the CSP-based RTS,S malaria vaccine may be limited against P. falciparum CSP alleles that diverge from the 3D7 vaccine allele, particularly in this polymorphic C-terminal region. In order to assess the breadth of the RTS,S-induced antibody responses against CSP C-terminal antigenic variants, we...
Source: Vaccine - January 8, 2021 Category: Allergy & Immunology Authors: Chaudhury S, MacGill RS, Early AM, Bolton JS, King CR, Locke E, Pierson T, Wirth DF, Neafsey DE, Bergmann-Leitner ES Tags: Vaccine Source Type: research

Genetic and antigenic characterization of wild type rubella viruses isolated from India.
Abstract Rubella, is a contagious disease caused by Rubella virus (RuV) that manifests as fever with skin-rashes in children and adults along with complications in pregnant women. WHO-SEAR has set a target for Rubella elimination by 2023. This is the first report of antigenic characterization and genome sequencing of nine RuVs sampled during 1992, 2007-9, and 2015-17 from four Indian states. Comparative analysis of Indian RuVs (2B) with that of global isolates and vaccine strain RA 27/3 (1a) revealed that the observed mutations in structural proteins have no major impact on the 3D structure, function and antigenic...
Source: Vaccine - January 7, 2021 Category: Allergy & Immunology Authors: Vaidya SR, Kasibhatla SM, Kamble MB, Munivenkatappa A, Kumbhar NS, Jayaswamy MM, Ramtirthkar MR, Kale MM, Kulkarni-Kale U Tags: Vaccine Source Type: research

Effect of educational and financial incentive-based interventions on immunization attitudes, beliefs, intentions and receipt among close contacts of pregnant women.
Abstract INTRODUCTION: Cocooning, the vaccination of close contacts of a newborn, is a strategy to limit the risk of pertussis and influenza infection among vulnerable infants. METHODS: Pregnant women in Colorado and Georgia referred close contacts to an app that provided tailored educational videos about vaccines along with a small pharmacy-based financial incentive for vaccine receipt. The primary objective of this study was to determine the feasibility of implementing this app-based cocooning intervention. RESULTS: Two hundred seventy seven contacts were enrolled in this study. Of those who received t...
Source: Vaccine - January 7, 2021 Category: Allergy & Immunology Authors: Dudley MZ, Taitel MS, Smith-Ray R, Singh T, Limaye RJ, Salmon DA Tags: Vaccine Source Type: research

A phase-I, open label clinical trial to assess the safety of Tdap vaccine manufactured by Serum Institute of India Pvt. Ltd. in adults.
CONCLUSION: Tdap vaccine manufactured by Serum Institute of India Pvt. Ltd. is safe and well tolerable in adults. It was concluded that further clinical development of this vaccine should continue to assess its safety and immunogenicity, in the target population. Clinical Trial Registration - CTRI/2017/03/008003. PMID: 33423838 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 7, 2021 Category: Allergy & Immunology Authors: Sharma H, Anil K, Parekh S, Pujari P, Shewale S, Madhusudhan RL, Patel J, Eswaraiah A, Shaligram U, Gairola S, Rao H Tags: Vaccine Source Type: research

How should we conduct pandemic vaccination?
Abstract Vaccination plays an important role in pandemic planning and response. The possibility of developing an effective vaccine for a novel pandemic virus is not assured. However, as we have seen with SARS-CoV-2 vaccine development, with sufficient resources and global focus, successful outcomes can be achieved in a relatively short period. However even when vaccine is available it will initially be scarce. When one becomes available, how should it be distributed? In this paper we explicate how ethical thinking that is carefully attuned to context is essential to decisions about how we should conduct vaccinatio...
Source: Vaccine - January 7, 2021 Category: Allergy & Immunology Authors: Williams J, Degeling C, McVernon J, Dawson A Tags: Vaccine Source Type: research

Assessment of neutralization of Micrurus venoms with a blend of anti-Micrurus tener and anti-ScNtx antibodies.
CONCLUSIONS: These results provide a proof-of-principle for using recombinant immunogens to enrich poor or even non-neutralizing antisera against elapid venoms containing short chain α-neurotoxins to develop antivenoms with higher effectiveness and broader neutralizing capacity. PMID: 33423840 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 7, 2021 Category: Allergy & Immunology Authors: Archundia IG, de la Rosa G, Olvera F, Calderón A, Benard-Valle M, Alagón A, Corzo G Tags: Vaccine Source Type: research

Regulatory Harmonization and Streamlining of Clinical Trial Applications globally should lead to faster clinical development and earlier access to life-saving vaccines.
Abstract Vaccines continue to play a central role in our ability to prevent disease, save lives, and improve health. The scientific community, including our own researchers, are driven by a shared purpose to improve vaccine technologies and bring the benefits of immunization to everyone, regardless of where they live - as soon as possible, especially when the medical need is considerable. Vaccine developers and manufacturers (sometimes referred to as "study sponsors" or "applicants") are exploring technological advancements to translate breakthrough discoveries into novel vaccines which have th...
Source: Vaccine - January 6, 2021 Category: Allergy & Immunology Authors: Scheppler L, De Clercq N, McGoldrick M, Dias J Tags: Vaccine Source Type: research

Direct and indirect effect of 10 valent pneumococcal vaccine on nasopharyngeal carriage in children under 2  years of age in Matiari, Pakistan.
Direct and indirect effect of 10 valent pneumococcal vaccine on nasopharyngeal carriage in children under 2 years of age in Matiari, Pakistan. Vaccine. 2021 Jan 06;: Authors: Nisar MI, Ahmed S, Jehan F, Shahid S, Shakoor S, Kabir F, Hotwani A, Munir S, Muhammad S, Khalid F, Althouse B, Hu H, Whitney C, Rodgers G, Klugman K, Ali A, Zaidi AKM, Omer SB, Iqbal N Abstract BACKGROUND: Pakistan introduced Ten-valent pneumococcal-conjugate-vaccine PCV10 in 2012 as a 3 + 0 schedule without catch-up. METHODS: Children
Source: Vaccine - January 6, 2021 Category: Allergy & Immunology Authors: Nisar MI, Ahmed S, Jehan F, Shahid S, Shakoor S, Kabir F, Hotwani A, Munir S, Muhammad S, Khalid F, Althouse B, Hu H, Whitney C, Rodgers G, Klugman K, Ali A, Zaidi AKM, Omer SB, Iqbal N Tags: Vaccine Source Type: research

Coping with COVID.
PMID: 33422380 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 6, 2021 Category: Allergy & Immunology Authors: Berman L, Riedel M Tags: Vaccine Source Type: research

Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990-2018.
Abstract BACKGROUND: Myopericarditis after vaccination has been sporadically reported in the medical literature. Here, we present a thorough descriptive analysis of reports to a national passive vaccine safety surveillance system (VAERS) of myopericarditis after vaccines licensed for use in the United States. METHODS: We identified U.S. reports of myopericarditis received by VAERS during 1990-2018 that met a published case definition for myopericarditis or were physician-diagnosed. We stratified analysis by age group (
Source: Vaccine - January 6, 2021 Category: Allergy & Immunology Authors: Su JR, McNeil MM, Welsh KJ, Marquez PL, Ng C, Yan M, Cano MV Tags: Vaccine Source Type: research

Quantifying preferences around vaccination against frequent, mild disease with risk for vulnerable persons: A discrete choice experiment among French hospital health care workers.
Abstract The individual determinants of vaccine acceptance among health workers (HCWs) have been described in the literature, but there is little evidence regarding the impact of vaccine characteristics and contextual factors (e.g., incentives, communication) on vaccination intentions. We developed a single profile discrete choice experiment (DCE) to assess the impact of seven attributes on stated vaccination intention against an unnamed disease, described as frequent with rapid clinical evolution and epidemic potential (similar to influenza or pertussis). Attributes evaluated vaccine characteristics (effectivenes...
Source: Vaccine - January 5, 2021 Category: Allergy & Immunology Authors: Godinot LD, Sicsic J, Lachatre M, Bouvet E, Abiteboul D, Rouveix E, Pellissier G, Raude J, Mueller JE Tags: Vaccine Source Type: research

Vaccination rate and adherence of tick-borne encephalitis vaccination in Germany.
ml;ß J Abstract BACKGROUND: Tick-borne encephalitis (TBE) is an arboviral infection of the central nervous system. As there is no causal treatment of TBE, disease prevention by vaccination is especially important. Immunization consists of a three-dose primary vaccination schedule, followed by regular booster doses. In Germany, the Standing Committee on Vaccination (STIKO) at the Robert Koch-Institute recommends TBE vaccination for all those at high risk of contracting TBE. This includes individuals living in, traveling to and/or working in risk areas, and being exposed to ticks. To our knowledge, there are c...
Source: Vaccine - January 4, 2021 Category: Allergy & Immunology Authors: Schley K, Malerczyk C, Beier D, Schiffner-Rohe J, von Eiff C, Häckl D, Süß J Tags: Vaccine Source Type: research

Constructing an ethical framework for priority allocation of pandemic vaccines.
We describe a framework for priority vaccine allocation that employed a cross-disciplinary approach, guided by ethical considerations and informed by local risk assessment. METHODS: Published and grey literature was reviewed, and augmented by consultation with key informants, to collate past experience, existing guidelines and emerging strategies for pandemic vaccine deployment. Identified ethical issues and decision-making processes were also included. Concurrently, simulation modelling studies estimated the likely impacts of alternative vaccine allocation approaches. Assembled evidence was presented to a workshop of...
Source: Vaccine - January 3, 2021 Category: Allergy & Immunology Authors: Fielding J, Sullivan SG, Beard F, Macartney K, Williams J, Dawson A, Gilbert GL, Massey P, Crooks K, Moss R, McCaw JM, McVernon J Tags: Vaccine Source Type: research

Evaluating the cost-effectiveness of maternal pertussis immunization in low- and middle-income countries: A review of lessons learnt.
Abstract This issue of Vaccine is devoted to papers from a research project that developed two types of simulation models, static and dynamic transmission, to evaluate the cost-effectiveness of maternal immunization to prevent pertussis in infants in low- and middle-income countries (LMICs). The research was conducted by a multinational team of investigators and funded by the Bill & Melinda Gates Foundation to gain an understanding of when and where maternal immunization might be a good public health investment for LMICs. Here we review the project's central lessons for vaccine policy and research. Models requ...
Source: Vaccine - December 13, 2020 Category: Allergy & Immunology Authors: Russell LB, Sobanjo-Ter Meulen A, Toscano CM Tags: Vaccine Source Type: research

Modeling the cost-effectiveness of maternal acellular pertussis immunization (aP) in different socioeconomic settings: A dynamic transmission model of pertussis in three Brazilian states.
CONCLUSIONS: The same model structure fit all three states best, supporting the idea that the disease behaves similarly across different socioeconomic conditions. We also found that immunization of pregnant women with aP is cost-effective in diverse Brazilian states. PMID: 33303180 [PubMed - in process] (Source: Vaccine)
Source: Vaccine - December 13, 2020 Category: Allergy & Immunology Authors: Luz PM, Struchiner CJ, Kim SY, Minamisava R, Andrade ALS, Sanderson C, Russell LB, Toscano CM Tags: Vaccine Source Type: research

The data used to build the models: Pertussis morbidity and mortality burden considering various Brazilian data sources.
CONCLUSION: Consistent disease burden patterns were observed over time in Brazil using a variety of data sources. Given the scarcity of good epidemiological data on pertussis available from low- and middle-income countries, our reported data provide valuable information for the assessment of the public health impact and cost-effectiveness modelling studies of newer strategies to prevent and control pertussis. These data were used to build and calibrate a national dynamic transmission model, which was used to evaluate the cost-effectiveness of maternal immunization. Clinical Trial registry name and registration number: Not ...
Source: Vaccine - December 13, 2020 Category: Allergy & Immunology Authors: Bagattini AM, Policena G, Minamisava R, Andrade ALS, Nishioka SA, Sinha A, Russell LB, Toscano CM Tags: Vaccine Source Type: research

Cost-effectiveness of maternal pertussis immunization: Implications of a dynamic transmission model for low- and middle-income countries.
This study evaluates the cost-effectiveness of maternal acellular pertussis (aP) immunization in low- and middle-income countries using a dynamic transmission model. METHODS: We developed a dynamic transmission model to simulate the impact of infant vaccination with whole-cell pertussis (wP) vaccine with and without maternal aP immunization. The model was calibrated to Brazilian surveillance data and then used to project health outcomes and costs under alternative strategies in Brazil, and, after adjusting model parameter values to reflect their conditions, in Nigeria and Bangladesh. The primary measure of cost-effect...
Source: Vaccine - December 13, 2020 Category: Allergy & Immunology Authors: Kim SY, Min KD, Jung SM, Russell LB, Toscano C, Minamisava R, Andrade ALS, Sanderson C, Sinha A Tags: Vaccine Source Type: research

Comparison of static and dynamic models of maternal immunization to prevent infant pertussis in Brazil.
Abstract BACKGROUND: This paper compares cost-effectiveness results from two models of maternal immunization to prevent pertussis in infants in Brazil, one static, one dynamic, to explore when static models are adequate for public health decisions and when the extra effort required by dynamic models is worthwhile. METHODS: We defined two scenarios to explore key differences between static and dynamic models, herd immunity and time horizon. Scenario 1 evaluates the incremental cost/DALY of maternal acellular pertussis (aP) immunization as routine infant vaccination coverage ranges from low/moderate up to, and ...
Source: Vaccine - December 13, 2020 Category: Allergy & Immunology Authors: Russell LB, Kim SY, Toscano C, Cosgriff B, Minamisava R, Lucia Andrade A, Sanderson C, Sinha A Tags: Vaccine Source Type: research

From bad to worse II: Risk amplification of the HPV vaccine on Facebook.
This study is the continuation of an analysis of the first decade of public, HPV-vaccine related Facebook posts. For this study, social amplification of risk framework concepts were analyzed to measure their relationships with post characteristics, engagement, and to see how those variables changed over time. METHODS: There were 6,506 public HPV vaccine-related Facebook posts (n = 6,506) within the first ten years after HPV vaccine's FDA approval (June 8, 2006 - June 8, 2016). Post characteristics, engagement, and social amplification of risk framework messages were coded (Krippendorf's alpha range: 0.67-1.0...
Source: Vaccine - December 7, 2020 Category: Allergy & Immunology Authors: Luisi MLR Tags: Vaccine Source Type: research

Bivalent non-typhoidal Salmonella outer membrane vesicles immunized mice sera confer passive protection against gastroenteritis in a suckling mice model.
This study also established the suckling mice model as a suitable animal model for vaccine study against iNTS mediated gastroenteritis. PMID: 33303233 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 7, 2020 Category: Allergy & Immunology Authors: Maiti S, Howlader DR, Halder P, Bhaumik U, Dutta M, Dutta S, Koley H Tags: Vaccine Source Type: research

Female-biased effects of aging on a chimeric hemagglutinin stalk-based universal influenza virus vaccine in mice.
Abstract To determine if biological sex and age intersect to affect universal influenza vaccine-induced immunity, adult and aged male and female C57BL/6 mice were sequentially immunized with a chimeric-hemagglutinin (cHA) stalk-based H1 vaccine. Adult mice developed greater quantity and quality of H1-stalk antibodies, that were more cross-reactive with other group 1, but not group 2, influenza viruses, than aged mice. The vaccine did not induce neutralizing or hemagglutination inhibition antibodies, but rather antibody-dependent cellular cytotoxicity, which was greater in adult than aged mice. Vaccinated adult mic...
Source: Vaccine - December 5, 2020 Category: Allergy & Immunology Authors: Dhakal S, Deshpande S, McMahon M, Strohmeier S, Krammer F, Klein SL Tags: Vaccine Source Type: research

PIPDeploy: Development and implementation of a gamified table top simulation exercise to strengthen national pandemic vaccine preparedness and readiness.
yen T Abstract Successful emergency vaccination campaigns rely on effective deployment and vaccination plans. This applies to localised outbreaks as well as for pandemics. In the wake of the 2009 H1N1 influenza pandemic, analysis of the global Vaccine Deployment Initiative, through which the World Health Organization (WHO) donated pandemic influenza vaccines to countries in need, revealed that an absence of vaccine deployment plans in many countries significantly hindered vaccine deployment. Through the Pandemic Influenza Preparedness Framework adopted by the World Health Assembly in 2011, WHO is engaging in sever...
Source: Vaccine - December 5, 2020 Category: Allergy & Immunology Authors: Ghiga I, Richardson S, Álvarez AMR, Kato M, Naidoo D, Otsu S, Nguyen PT, Nguyen PN, Nguyen T Tags: Vaccine Source Type: research

Trends in the uptake of pediatric measles-containing vaccine in the United States: A Disneyland effect?
CONCLUSIONS: The Disneyland outbreak was associated with differential effects on MCV coverage by maternal education and decreases in MCV administration age among U.S. children. These findings may provide useful insights to inform methods to address pediatric MCV undervaccination. PMID: 33288341 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 4, 2020 Category: Allergy & Immunology Authors: Doll MK, Weitzen SD, Morrison KT Tags: Vaccine Source Type: research

National vaccine coverage trends and funding in Latin America and the Caribbean.
CONCLUSIONS: Fewer countries across Latin America and the Caribbean are currently achieving optimum national vaccine coverage and weak to moderate relationships between routine immunization and vaccine expenditures and coverage were observed. Additional factors contributing to national vaccine coverage should be concomitantly examined to implement strategies which optimize delivery of childhood immunizations. PMID: 33288342 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 4, 2020 Category: Allergy & Immunology Authors: Llau AF, Williams ML, Tejada CE Tags: Vaccine Source Type: research

Cost-effectiveness of live-attenuated influenza vaccination among school-age children.
This study aims to evaluate the cost-effectiveness of prioritizing vaccination to age groups within the 2-16 year old age range to mitigate the operational and resource challenges of the current strategy. We performed economic evaluations comparing the influenza vaccination program from 1995-2013 to seven alternative strategies targeted at low risk individuals along the school age divisions Preschool (2-4 years old), Primary school (5-11 years old), and Secondary school (12-16 years old). These extensions are evaluated incrementally on the status quo scenario (vaccinating subgroups at high risk of influ...
Source: Vaccine - December 4, 2020 Category: Allergy & Immunology Authors: Wenzel NS, Atkins KE, van Leeuwen E, Halloran ME, Baguelin M Tags: Vaccine Source Type: research

Safety of maternal pertussis vaccination on pregnancy and birth outcomes: A prospective cohort study.
CONCLUSION: Our study provides reassuring evidence of the safety of maternal pertussis vaccination with no increased risk of adverse pregnancy and birth outcomes. These findings support recommendations for pertussis vaccination during pregnancy to prevent morbidity and mortality associated with early-infant pertussis disease. PMID: 33280854 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 3, 2020 Category: Allergy & Immunology Authors: Mohammed H, Roberts CT, Grzeskowiak LE, Giles LC, Verburg PE, Dekker G, Marshall HS Tags: Vaccine Source Type: research

Understanding the messages and motivation of vaccine hesitant or refusing social media influencers.
Abstract BACKGROUND: While anti-vaccine messages on social media have been studied for content, reach, and effectiveness, less is known about those who create and promote the messages. Online influencers, or 'everyday people who are influential within their online social networks', are viewed as trusted voices who are often making similar life decisions as their followers. Therefore, their experiences with and perspectives on health issues can be persuasive. METHODS: We collaborated with a formal network of online influencers to interview, using a semi-structured interview guide, vaccine hesitant influencer m...
Source: Vaccine - December 3, 2020 Category: Allergy & Immunology Authors: Leader AE, Burke-Garcia A, Massey PM, Roark JB Tags: Vaccine Source Type: research

Effects of measles-containing vaccination in children with severe underlying neurologic disease.
CONCLUSION: Ina series of children with prior severe neurologic disease, the safety-tolerability profile ofvaccines containing a measles vaccine component suggests that vaccination is justified. Main side effect was seizure aggravation in children with known epileptic disease. PMID: 33280857 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 3, 2020 Category: Allergy & Immunology Authors: Dimopoulou D, Koutsaki M, Giorgi M, Spanou M, Dinopoulos A, Papaevangelou V Tags: Vaccine Source Type: research

Efficacy of m-Health for the detection of adverse events following immunization - The stimulated telephone assisted rapid safety surveillance (STARSS) randomised control trial.
CONCLUSION: We have demonstrated that the STARSS methodology improves AEFI detection. Our findings should inform the wider use of SMS-based surveillance which is particularly relevant since establishing robust and novel pharmacovigilance systems is critical to monitoring novel vaccines which includes potential COVID vaccines. PMID: 33279317 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 2, 2020 Category: Allergy & Immunology Authors: Gold MS, Lincoln G, Cashman P, Braunack-Mayer A, Stocks N Tags: Vaccine Source Type: research

Mobile phone reminders for enhancing uptake, completeness and timeliness of routine childhood immunization in low and middle income countries: A systematic review and meta-analysis.
Abstract Immunization remains one of the most effective public health interventions offering protection for children from vaccine preventable diseases. However, many children living in low- and- middle income countries do not get adequate immunization due to several factors. Mobile phone reminder interventions have shown great potential in enhancing a number of immunization outcomes. However, the evidence supporting its use in these countries is vague. This systematic review was conducted to provide evidence for mobile phone reminder in enhancing immunization uptake, completeness and timeliness. This review was co...
Source: Vaccine - December 1, 2020 Category: Allergy & Immunology Authors: Yunusa U, Garba SN, Umar AB, Idris SH, Bello UL, Abdulrashid I, Mohammed J Tags: Vaccine Source Type: research

Safety of the adjuvanted recombinant zoster vaccine in adults aged 50  years or older. A phase IIIB, non-randomized, multinational, open-label study in previous ZOE-50 and ZOE-70 placebo recipients.
CONCLUSIONS: Nature and incidence of AEs, SAEs, and pIMDs were as expected and in line with the parent studies. PMID: 33277059 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - December 1, 2020 Category: Allergy & Immunology Authors: Ocran-Appiah J, Boutry C, Hervé C, Soni J, Schuind A, ZOSTER-056 Study Group Tags: Vaccine Source Type: research

Corrigendum to "Getting the most from the Ebola vaccine success" [Vaccine 33 (2015) 7141].
Corrigendum to "Getting the most from the Ebola vaccine success" [Vaccine 33 (2015) 7141]. Vaccine. 2020 Nov 30;: Authors: Focosi D, Maggi F, Pistello M PMID: 33272700 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 30, 2020 Category: Allergy & Immunology Authors: Focosi D, Maggi F, Pistello M Tags: Vaccine Source Type: research

HED: Trying to work our way back to normal.
PMID: 33272701 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 30, 2020 Category: Allergy & Immunology Authors: Davis J Tags: Vaccine Source Type: research

A cost-effectiveness analysis of South Africa's seasonal influenza vaccination programme.
CONCLUSION: South Africa's seasonal influenza vaccination strategy of opportunistically targeting vulnerable populations during routine visits is cost-effective. A budget impact analysis will be useful for supporting future expansions of the programme. PMID: 33272702 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 30, 2020 Category: Allergy & Immunology Authors: Edoka I, Kohli-Lynch C, Fraser H, Hofman K, Tempia S, McMorrow M, Ramkrishna W, Lambach P, Hutubessy R, Cohen C Tags: Vaccine Source Type: research

Safety profile of rotavirus vaccines among individuals aged  ≥8 months of age, United States, vaccine adverse event reporting system (VAERS), 2006-2019.
CONCLUSIONS: We did not identify any unexpected AEs for RV vaccines among individuals aged ≥8 months. Health care providers should adhere to the ACIP recommended schedule and older individuals should apply necessary precautions to prevent potential secondary exposure from vaccinated children. PMID: 33267969 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 29, 2020 Category: Allergy & Immunology Authors: Haber P, Tate J, Marquez PL, Moro PL, Parashar U Tags: Vaccine Source Type: research

Public health impact and cost-effectiveness of a nine-valent gender-neutral HPV vaccination program in France.
CONCLUSIONS: In France, GNV has a significant impact in terms of public health benefits and may be considered cost-effective compared with GOV at low and high coverage rates. PMID: 33261895 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 28, 2020 Category: Allergy & Immunology Authors: Majed L, Bresse X, El Mouaddin N, Schmidt A, Daniels VJ, Pavelyev A, Levy-Bachelot L, Elbasha E Tags: Vaccine Source Type: research

A systematic review of factors that influence the acceptability of vaccines among Canadians.
CONCLUSIONS: The NACI vaccine acceptability matrix is useful for categorizing acceptability factors for the general public. Reminder systems may improve the uptake of childhood vaccines. Policies that make the rotavirus vaccine universally available and easily accessible may improve coverage. FUNDING: This systematic review was completed under contract to the Public Health Agency of Canada, Contract #4600001536. PMID: 33257103 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 27, 2020 Category: Allergy & Immunology Authors: Gates A, Gates M, Rahman S, Guitard S, MacGregor T, Pillay J, Ismail SJ, Tunis MC, Young K, Hardy K, Featherstone R, Hartling L Tags: Vaccine Source Type: research

Adjustments for oral fluid quality and collection methods improve prediction of circulating tetanus antitoxin: Approaches for correcting antibody concentrations detected in a non-invasive specimen.
CONCLUSIONS: Anti-TT IgG in OF is a good proxy for levels in serum, after controlling for total IgG in the specimen and other variables. Post hoc adjustments for OF volume and total IgG concentration are an important consideration when conducting serosurveys with oral fluid. PMID: 33257104 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 27, 2020 Category: Allergy & Immunology Authors: Garrison-Desany H, Ochieng BO, Odiere MR, Kuo H, Gibson DG, Were J, Kagucia EW, Pasetti MF, Kim H, Reymann M, O'Brien K, Hayford K Tags: Vaccine Source Type: research

Vaccination with chimeric protein induces protection in murine model against ascariasis.
Abstract An estimated 400 million people are infected by parasites of the genus Ascaris and the existing control measures are inefficient. Vaccine development using B cell antigens is a promising strategy for increased protection against this parasite. The present study aimed at developing a chimeric protein capable of conferring protection against infection by Ascaris sp. For this purpose, we performed B-cell epitope predictions on previously described vaccine candidate proteins from Ascaris suum and the corresponding peptides were used to construct a chimeric protein. Female BALB / c mice were immunized subcutan...
Source: Vaccine - November 26, 2020 Category: Allergy & Immunology Authors: de Castro JC, de Almeida LV, Cardoso MS, Oliveira FMS, Nogueira DS, Reis-Cunha JL, Magalhaes LMD, Zhan B, Bottazzi ME, Hotez PJ, Bueno LL, Bartholomeu DC, Fujiwara RT Tags: Vaccine Source Type: research

Long-lasting heterologous antibody responses after sequential vaccination with A/Indonesia/5/2005 and A/Vietnam/1203/2004 pre-pandemic influenza A(H5N1) virus vaccines.
CONCLUSIONS: Sequential vaccination with two different A(H5N1) pre-pandemic vaccines induced long-lasting high level cross-clade immunity against influenza A(H5N1) strains, thus supporting a prime-boost vaccination strategy in pandemic preparedness plans. PMID: 33246672 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 24, 2020 Category: Allergy & Immunology Authors: Haveri A, Ikonen N, Savolainen-Kopra C, Julkunen I Tags: Vaccine Source Type: research

A nationwide post-marketing survey of knowledge, attitude and practice toward human papillomavirus vaccine in general population: Implications for vaccine roll-out in mainland China.
CONCLUSIONS: Findings highlight a lack of vaccine awareness, knowledge, and poor uptake in mainland China and underscore the necessity of health education campaigns. The identified priority groups, contents to be delivered and practical obstacles could furthermore provide insight into health education to reduce disparities and accelerate HPV vaccine roll-out in China. PMID: 33243631 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 23, 2020 Category: Allergy & Immunology Authors: Hu S, Xu X, Zhang Y, Liu Y, Yang C, Wang Y, Wang Y, Yu Y, Hong Y, Zhang X, Bian R, Cao X, Xu L, Zhao F Tags: Vaccine Source Type: research

Impact and effectiveness of the 10-valent pneumococcal conjugate vaccine on invasive pneumococcal disease among children under 5  years of age in the Netherlands.
We report on impact and effectiveness against invasive pneumococcal disease (IPD) in children aged under 5 years by switching from PCV7 to PCV10. METHOD: We included IPD cases between 2004 and 2019 in children aged 
Source: Vaccine - November 23, 2020 Category: Allergy & Immunology Authors: Peckeu L, van der Ende A, de Melker HE, Sanders EAM, Knol MJ Tags: Vaccine Source Type: research

Influenza vaccine effectiveness against laboratory-confirmed influenza in a vaccine-mismatched influenza B-dominant season.
CONCLUSIONS: The moderate-high 2017-2018 influenza A VE among children and adolescents, supports seasonal influenza vaccination at a young age. The low VE against influenza B in Israel, is most likely the result of influenza B/TIV-mismatch. PMID: 33243633 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 23, 2020 Category: Allergy & Immunology Authors: Drori Y, Pando R, Sefty H, Rosenberg A, Mendelson E, Keinan-Boker L, Shohat T, Mandelboim M, Glatman-Freedman A, Israel Influenza Surveillance Network IISN Tags: Vaccine Source Type: research

Comparison of influenza antibody titers among women who were vaccinated in the 2nd and the 3rd trimesters of pregnancy.
CONCLUSIONS: Pregnant women vaccinated against influenza had more placental transfer of influenza antibodies to their infants than unvaccinated women. Placental transfer of antibodies was higher among those vaccinated in the 3rd trimester than in the 2nd trimester. There was no difference in the proportions of women achieving antibody titers corresponding to protection against influenza in children. Findings support the current World Health Organization's recommendation that pregnant women may be vaccinated in either 2nd or 3rd trimester of pregnancy. PMID: 33243634 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 23, 2020 Category: Allergy & Immunology Authors: Kittikraisak W, Phadungkiatwatana P, Ditsungnoen D, Kaoiean S, Macareo L, Rungrojcharoenkit K, Srisantiroj N, Chotpitayasunondh T, Dawood FS, Mott JA, Lindblade KA Tags: Vaccine Source Type: research

Duration of seropositivity following yellow fever vaccination in U.S. military service members.
CONCLUSIONS: Neutralizing antibodies were present in > 95% of vaccine recipients for at least 19 years after vaccination, suggesting that booster doses every 10 years are not essential for most U.S. military personnel. PMID: 33239225 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 22, 2020 Category: Allergy & Immunology Authors: Lindsey NP, Perry L, Fischer M, Woolpert T, Biggerstaff BJ, Brice G, Fitzpatrick K, Kosoy OI, Laven JJ, Myers CA, Hollis EM, Staples JE Tags: Vaccine Source Type: research

Hepatitis A antibody persistence 8 and 10  years after 1-dose and 2-dose vaccination in children from Panama.
This study (NCT02712359) included 600 and 599 children at Y8 and Y10 post-vaccination, respectively. Seropositivity rates were 74.3% (95% confidence interval [CI]: 69.0; 79.2) and 97.7% (95% CI: 95.3; 99.1) at Y8 and 71.9% (95% CI: 66.4; 76.9) and 96.3% (95% CI: 93.5; 98.2) at Y10, in the 1-dose and 2-dose groups, respectively. Antibody GMCs were lower in the 1-dose versus the 2-dose group in both surveys. Non-inferiority was not demonstrated since the lower limit of the 2-sided 95% CI for the between-group difference in seropositivity rates (1-dose minus 2-dose) was 
Source: Vaccine - November 22, 2020 Category: Allergy & Immunology Authors: Juliao P, Abadia I, Welby S, Wéry S, Wong D, De Léon T, DeAntonio R, Naranjo L, Guignard A, Marano C Tags: Vaccine Source Type: research

Association between human papillomavirus vaccine status and sexually transmitted infection outcomes among females aged 18-35 with a history of sexual activity in the United States: A population survey-based cross-sectional analysis.
CONCLUSION: Among females who reported a history of sexual activity, HPV vaccination status was protective against vaccine-type HPV and not associated with lab-based STI outcomes. Although findings may be susceptible to reporting bias, results indicating low vaccine uptake at routine-recommended ages requires additional efforts promoting HPV vaccination before sexual-debut. PMID: 33239227 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 22, 2020 Category: Allergy & Immunology Authors: Closson K, Karim ME, Sadarangani M, Naus M, Ogilvie GS, Donken R Tags: Vaccine Source Type: research