Streptococcus pneumoniae as a colonizing agent of the Nasopharynx - Oropharynx in adults: A systematic review and meta-analysis
CONCLUSIONS: This study found a low prevalence of Spn NOC in adults. Notably, the prevalence of Spn NOC was higher in younger adults than in older adults. It is essential to highlight a significant heterogeneity among studies, which indicates there is no standardized method of Spn NOC identification.PMID:38514352 | DOI:10.1016/j.vaccine.2024.03.041 (Source: Vaccine)
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Juli án Lozada Juan Olivella G ómez Cristian C Serrano-Mayorga Andr é Emilio Viñán Garcés Valeria Enciso Lina Mendez-Castillo Alejandro Acosta-Gonz ález Ingrid G Bustos Yuli V Fuentes Elsa D Ib áñez-Prada Ana M Crispin Mar ía C Delgado-Cañavera Source Type: research
Yellow fever neutralizing antibody seroprevalence proportion and titers in previously vaccinated adults with chronic kidney disease
Vaccine. 2024 Mar 20:S0264-410X(24)00316-5. doi: 10.1016/j.vaccine.2024.03.029. Online ahead of print.ABSTRACTStudies on yellow fever vaccine (YF) in chronic kidney disease (CKD) patients are scarce. This cross-sectional study aimed to evaluate YF neutralizing antibody seroprevalence and titers in previously vaccinated adults with CKD, on dialysis (D-CKD) or not (ND-CKD), compared to healthy persons. The micro Plaque Reduction Neutralization-Horseradish Peroxidase (μPRN-HP) test was used. Antibody titers were expressed as the reciprocal of the highest dilution that neutralized the challenge virus by 50 % (μPRN50). Seropo...
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Camila Cristina Martini Rodrigues Amanda Caroline Ribeiro Sales Ana Marli Christovam Sartori Adriana de Souza Azevedo Sheila Maria Barbosa de Lima Camila de Melo Picone Paula Keiko Sato Amanda Nazareth Lara Karina Takesaki Miyaji Luiz S érgio Azevedo Bru Source Type: research
The influence of health service interactions and local policies on vaccination decision-making in immigrant women: A multi-site Canadian qualitative study
CONCLUSION: Given our participants' different communication preferences and needs, we argue that a one-size-fits-all communication approach is inappropriate for immigrant and refugee populations. Instead, multi-pronged communication strategies are required to reach participants and respond to previous experiences and information that may lead to vaccination hesitancy.PMID:38514354 | DOI:10.1016/j.vaccine.2024.03.014 (Source: Vaccine)
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Stephanie P Brooks Kamaljit Sidhu Elizabeth Cooper S Michelle Driedger Linda Gisenya Gagandeep Kaur Marinel Kniseley Cynthia G Jardine Source Type: research
Humoral and cellular immunity to SARS-CoV-2 following vaccination with non-mRNA vaccines in adolescent/young adults with cancer: A prospective cohort study
CONCLUSION: Among AYA cancer patients, a single non-mRNA vaccine dose confers robust hybrid humoral immunity with limited benefit from a second dose.PMID:38514355 | DOI:10.1016/j.vaccine.2024.03.042 (Source: Vaccine)
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Archana Sasi Jyotsna Dandotiya Jyotsana Kaushal Shuvadeep Ganguly Akshay Binayke K M Ambika Akshi Shree Farhana Jahan Priyanka Sharma Tejas Menon Suri Amit Awasthi Sameer Bakhshi Source Type: research
Differences in social media use by COVID-19 vaccination status
Vaccine. 2024 Mar 20:S0264-410X(24)00318-9. doi: 10.1016/j.vaccine.2024.03.031. Online ahead of print.ABSTRACTThe near-ubiquitous use of social media in the United States (U.S.) highlights the utility of social media for encouraging vaccination. Vaccination campaigns have used social media to reach audiences, yet research linking the use of specific social media platforms and vaccination uptake is nascent. This descriptive study assesses differences in social media use by COVID-19 vaccination status among adults overall and those who reported baseline vaccine hesitancy. We used data from a nationally representative longitu...
Source: Vaccine - March 21, 2024 Category: Allergy & Immunology Authors: Kenneth W Moffett Kate Seserman Katherine A Margolis Elissa C Kranzler Michael C Marshall Heather Dahlen Jae-Eun C Kim Benjamin Denison Blake Hoffman Daphney Dupervil Kathleen Yu Leah Hoffman Source Type: research
Is vaccination against measles, mumps, and rubella associated with reduced rates of antibiotic treatments among children below the age of 2 years? Nationwide register-based study from Denmark, Finland, Norway, and Sweden
CONCLUSIONS: Across the Nordic countries, receipt of MMR vaccine after DTaP3 was associated with an 11% lower rate of antibiotic treatments. The negative control analysis suggests that the findings are affected by residual confounding. Findings suggest that potential non-specific effects of MMR vaccine are of limited clinical and public health importance for the milder infections treated out-of-hospital in the Nordic setting.PMID:38508926 | DOI:10.1016/j.vaccine.2024.03.026 (Source: Vaccine)
Source: Vaccine - March 20, 2024 Category: Allergy & Immunology Authors: Lise Gehrt H élène Englund Ida Laake Heta Nieminen S ören Möller Berit Feiring Mika Lahdenkari Lill Trogstad Christine Stabell Benn Signe S ørup Source Type: research
Transformative vaccination: A pentavalent shield against COVID-19 and influenza with betulin-based adjuvant for enhanced immunity
Vaccine. 2024 Mar 19:S0264-410X(23)01421-4. doi: 10.1016/j.vaccine.2023.11.057. Online ahead of print.ABSTRACTThe development of an effective combined vaccine represents a crucial strategy for preventing outbreaks of infectious diseases and reducing the burden on healthcare resources. Developing a combined vaccine against both influenza and the coronavirus is a promising approach, but it is still in the early stages of development. This paper reports on a novel combined pentavalent candidate vaccine that has shown promising results in mice, with statistically significant differences in mean antibody titer against the coron...
Source: Vaccine - March 20, 2024 Category: Allergy & Immunology Authors: Igor Krasilnikov Artur Isaev Milana Djonovic Alexander Ivanov Ekaterina Romanovskaya-Romanko Marina Stukova Vitaly Zverev Source Type: research
Humoral and cellular immune responses induced by serogroup W135 meningococcal conjugate and polysaccharide vaccines
Vaccine. 2024 Mar 19:S0264-410X(24)00326-8. doi: 10.1016/j.vaccine.2024.03.039. Online ahead of print.ABSTRACTInvestigating the mechanisms by which W135 meningococcal conjugate (PSW135-TT) activates adaptive immune responses in mice can provide a comprehensive understanding of the immune mechanisms of bacterial polysaccharide conjugate vaccines. We compared B-cell and T-cell immune responses immunized with W135 meningococcal capsular polysaccharides (PSW135), tetanus toxoid (TT) and PSW135-TT in mice. The results showed that PSW135-TT could induce higher PSW135-specific and TT-specific IgG antibodies with a significant enh...
Source: Vaccine - March 20, 2024 Category: Allergy & Immunology Authors: Yahui Cheng Rong Shen Fanglei Liu Yanting Li Jing Wang Yali Hou Yueping Liu Haifei Zhou Fengping Hou Yunjin Wang Xiongxiong Li Ruijie Qiao Shuquan Luo Source Type: research
Subolesin knockdown in tick cells provides insights into vaccine protective mechanisms
In this study, transcriptomics and proteomics analyses were conducted together with graph theory data analysis in wild type and Sub knockdown (KD) tick ISE6 cells in order to identify and characterize the functional implications of Sub in tick cells. The results support a key role for Sub in the regulation of gene expression in ticks and the relevance of this antigen in vaccine development against ticks and TBDs. Proteins with differential representation in response to Sub KD provide insights into vaccine protective mechanisms and candidate tick protective antigens.PMID:38508929 | DOI:10.1016/j.vaccine.2024.03.006 (Source: Vaccine)
Source: Vaccine - March 20, 2024 Category: Allergy & Immunology Authors: Sara Artigas-Jer ónimo Margarita Villar Agust ín Estrada-Peña Pilar Alberdi Jos é de la Fuente Source Type: research
Mucosal immunization with dual influenza/COVID-19 single-replication virus vector protects hamsters from SARS-CoV-2 challenge
Vaccine. 2024 Mar 19:S0264-410X(24)00327-X. doi: 10.1016/j.vaccine.2024.03.040. Online ahead of print.ABSTRACTThe COVID-19 pandemic has highlighted the need for mucosal vaccines as breakthrough infections, short-lived immune responses and emergence of new variants have challenged the efficacy provided by the first generation of vaccines against SARS-CoV-2 viruses. M2SR SARS-CoV-2, an M2-deleted single-replication influenza virus vector modified to encode the SARS-CoV-2 receptor binding domain, was evaluated following intranasal delivery in a hamster challenge model for protection against Wuhan SARS-CoV-2. An adjuvanted ina...
Source: Vaccine - March 20, 2024 Category: Allergy & Immunology Authors: Lindsay Hill-Batorski Richard Bowen Helle Bielefeldt-Ohmann Michael J Moser Sarah M Matejka David Marshall Yoshihiro Kawaoka Gabriele Neumann Pamuk Bilsel Source Type: research
High throughput AS LNA qPCR method for the detection of a specific mutation in poliovirus vaccine strains
In conclusion, the developed AS LNA qPCR presents a valuable low-cost, and fast tool, suitable for the process development and quality control of polio vaccines.PMID:38503660 | DOI:10.1016/j.vaccine.2024.01.103 (Source: Vaccine)
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Lizet Opmeer Isabella Gazzoli M ónika Ballmann Marieke Willemsen Gerben P Voshol Magda Grudniewska-Lawton Menzo Havenga Christopher Yallop Ahd Hamidi Gert Gillissen Wilfried A M Bakker Source Type: research
Vaccine value profile for Klebsiella pneumoniae
Vaccine. 2024 Mar 18:S0264-410X(24)00248-2. doi: 10.1016/j.vaccine.2024.02.072. Online ahead of print.ABSTRACTKlebsiella pneumoniae causes community- and healthcare-associated infections in children and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) and 4.95 million (95% UI: 3.62-6.57) deaths were attributed to and associated with bacterial antimicrobial resistance (AMR), respectively. K. pneumoniae was the second leading pathogen in deaths attributed to AMR resistant bacteria. Furthermore, the rise of antimicrobial resistance in both community- and hospital-acquired infectio...
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Ziyaad Dangor Nicole Benson James A Berkley Julia Bielicki Merijn W Bijsma Jonathan Broad Ed T Buurman Alan Cross Erin M Duffy Kathryn E Holt Pui-Ying Iroh Tam Mark Jit Konstantinos Karampatsas Michael Katwere Gaurav Kwatra Ramanan Laxminarayan Kirsty Le Source Type: research
Measles vaccination coverage and immunization status of nurses: An interventional study in T ürkiye
CONCLUSION: Expanding the immunization scope in hospitals by screening for measles antibodies among healthcare personnel and vaccinating those who are seronegative can be considered an effective public health strategy.PMID:38503662 | DOI:10.1016/j.vaccine.2024.03.037 (Source: Vaccine)
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Volkan Medeni Özge Tonbuloğlu Altıner İrem Medeni Source Type: research
Comparison of the safety and efficacy of the wild-type and lpxL/lpxM mutant inactivated vaccine against the avian pathogenic Escherichia coli O1, O2, and O78 challenge
In this study, mutant strains of lpxL/lpxM and their O1, O2, and O78 wild-type strains were developed for an inactivated vaccine (referred to as the mutant vaccine and the wild-type vaccine, respectively), and the safety and effectiveness of these two prototype vaccines were assessed in white Leghorn chickens. Findings indicated that chickens immunized with the mutant vaccine showed a return of appetite sooner post-immunization and experienced earlier disappearance of nodules at the injection site compared to those immunized with the wild-type vaccine. Pathological examinations revealed that lesions were still present in t...
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Jiayan Wu Luyao Jiang Qiwen Shao Juanhua Liu Hang Wang Qingqing Gao Changchao Huan Xiaobo Wang Song Gao Source Type: research
CHO cells for virus-like particle and subunit vaccine manufacturing
Vaccine. 2024 Mar 18:S0264-410X(24)00321-9. doi: 10.1016/j.vaccine.2024.03.034. Online ahead of print.ABSTRACTChinese Hamster Ovary (CHO) cells, employed primarily for manufacturing monoclonal antibodies and other recombinant protein (r-protein) therapeutics, are emerging as a promising host for vaccine antigen production. This is exemplified by the recently approved CHO cell-derived subunit vaccines (SUV) against respiratory syncytial virus (RSV) and varicella-zoster virus (VZV), as well as the enveloped virus-like particle (eVLP) vaccine against hepatitis B virus (HBV). Here, we summarize the design, production, and immu...
Source: Vaccine - March 19, 2024 Category: Allergy & Immunology Authors: Zalma V Sanchez-Martinez Sergio P Alpuche-Lazcano Matthew Stuible Yves Durocher Source Type: research
