An inactivated whole-virion vaccine for Enterovirus D68 adjuvanted with CpG ODN or AddaVax elicits potent protective immunity in mice
Vaccine. 2024 Mar 11:S0264-410X(24)00303-7. doi: 10.1016/j.vaccine.2024.03.016. Online ahead of print.ABSTRACTEnterovirus D68 (EV-D68), a pathogen that causes respiratory symptoms, mainly in children, has been implicated in acute flaccid myelitis, which is a poliomyelitis-like paralysis. Currently, there are no licensed vaccines or treatments for EV-D68 infections. Here, we investigated the optimal viral inactivation reagents, vaccine adjuvants, and route of vaccination in mice to optimize an inactivated whole-virion (WV) vaccine against EV-D68. We used formalin, β-propiolactone (BPL), and hydrogen peroxide as viral inact...
Source: Vaccine - March 12, 2024 Category: Allergy & Immunology Authors: Kota Senpuku Chikako Kataoka-Nakamura Yuta Kunishima Toshiro Hirai Yasuo Yoshioka Source Type: research
SimSAARlabim study - The role magic tricks play in reducing pain and stress in children
CONCLUSIONS: Although children undergoing routine outpatient vaccination appeared to enjoy a magician's presence, the concomitant performance of magic tricks revealed no significant effect on the stress response.PMID:38472068 | DOI:10.1016/j.vaccine.2024.03.021 (Source: Vaccine)
Source: Vaccine - March 12, 2024 Category: Allergy & Immunology Authors: Jutta Teichfischer Regine Weber Elisabeth Kaiser Martin Poryo Julius Johannes Weise Alexander Nisius Sascha Meyer Source Type: research
Partisan divide and Racial/Ethnic disparities in COVID-19 vaccine hesitancy among Parents/Guardians and vaccine uptake among children in the U.S
CONCLUSIONS: We found that children were less likely to receive a COVID-19 vaccine if they resided in Republican as compared to Democratic states, with the difference in probability greatest among those households where parents/guardians identified as White. We also found that children were less likely to receive a COVID-19 vaccine if their parents/guardians identified as White as compared to any other race/ethnicity, with the differences in probability greatest among households in Republican states.PMID:38472069 | DOI:10.1016/j.vaccine.2024.03.022 (Source: Vaccine)
Source: Vaccine - March 12, 2024 Category: Allergy & Immunology Authors: Alice Shijia Yan Neil Jay Sehgal Source Type: research
Effectiveness of one and two doses of acellular pertussis vaccines against laboratory-confirmed pertussis requiring hospitalisation in infants: Results of the PERTINENT sentinel surveillance system in six EU/EEA countries, December 2015 - December 2019
CONCLUSIONS: Our results suggest moderate one-dose and two-dose VE in infants. Larger sample size would allow more precise estimates for dose one, two and three.PMID:38472070 | DOI:10.1016/j.vaccine.2024.02.090 (Source: Vaccine)
Source: Vaccine - March 12, 2024 Category: Allergy & Immunology Authors: Lore Merdrignac Fatima A ït El Belghiti Elisabetta Pandolfi Lesly Acosta Kate řina Fabiánová Adele Habington Manuel Garc ía Cenoz H åkon Bøås Julie Toubiana Alberto E Tozzi Iolanda Jordan Jana Zavadilov á Niam O'Sullivan Ana Navascu és Elmira Fl Source Type: research
Safety monitoring of bivalent mRNA COVID-19 vaccine among pregnant persons in the vaccine adverse event reporting System - United States, September 1, 2022 - March 31, 2023
CONCLUSIONS: Based on this review of reports to VAERS, the safety profile of bivalent mRNA COVID-19 vaccination in pregnant persons was comparable to that observed for monovalent mRNA COVID-19 booster vaccination (3rd and 4th dose) in pregnant persons.PMID:38462432 | DOI:10.1016/j.vaccine.2024.02.084 (Source: Vaccine)
Source: Vaccine - March 10, 2024 Category: Allergy & Immunology Authors: Pedro L Moro Grace Carlock Nimita Fifadara Tei Habenicht Bicheng Zhang Penelope Strid Paige Marquez Source Type: research
Safety monitoring of bivalent mRNA COVID-19 vaccine among pregnant persons in the vaccine adverse event reporting System - United States, September 1, 2022 - March 31, 2023
CONCLUSIONS: Based on this review of reports to VAERS, the safety profile of bivalent mRNA COVID-19 vaccination in pregnant persons was comparable to that observed for monovalent mRNA COVID-19 booster vaccination (3rd and 4th dose) in pregnant persons.PMID:38462432 | DOI:10.1016/j.vaccine.2024.02.084 (Source: Vaccine)
Source: Vaccine - March 10, 2024 Category: Allergy & Immunology Authors: Pedro L Moro Grace Carlock Nimita Fifadara Tei Habenicht Bicheng Zhang Penelope Strid Paige Marquez Source Type: research
Intranasal delivery of a self-adjuvanted nanovaccine composed of the curli filaments and the highly conserved M2e epitope confers protection against influenza a virus in mice
Vaccine. 2024 Mar 8:S0264-410X(24)00222-6. doi: 10.1016/j.vaccine.2024.02.063. Online ahead of print.ABSTRACTIntranasal administration of vaccines is an attractive delivery route to fight viral respiratory infections. However, there are only a few intranasal vaccines used in human, emphasizing the critical need to identify novel safe mucosal adjuvants and antigen delivery systems to expand their usage. We recently revealed an immunostimulating nanoparticle based on a fragment (R4R5) of the Curli-specific gene A (CsgA) protein that confers protection against influenza A virus (IAV) when conjugated to three repeats of the hi...
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Philippe St-Louis Cl ément Martin Vinay Khatri Steve Bourgault Denis Archambault Source Type: research
Vaccination during pregnancy and modulation of IgG response to pertussis vaccines in infants: The impact of different vaccine formulations
Vaccine. 2024 Mar 8:S0264-410X(24)00300-1. doi: 10.1016/j.vaccine.2024.03.015. Online ahead of print.ABSTRACTThe IgG response following infant diphtheria-tetanus-acellular pertussis (DTaP) immunization is influenced by the formulation of the infant and/or the adult vaccine (Tdap) given during pregnancy. DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducting a secondary analysis of a large randomized controlled trial, we compared IgG levels against pertussis vaccine antigens in children of Td- and Tdap5-vaccinated mothers, after stratifying by infant vaccine formulation. A...
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Nicholas Brousseau Marie-Elen Angers-Goulet Robin Bastien Lingyun Ye Manish Sadarangani Scott A Halperin Source Type: research
Pandemic antecedents - Exploring predictivity and relationships between COVID-19 vaccine uptake and influenza, shingles, and HPV vaccination
CONCLUSION: Experience with COVID-19 vaccination and the relationship of those experiences with other vaccinations provide useful insight on leveraging vaccine uptake. Healthcare professionals should improve the COVID-19 vaccination experience and use vaccination appointments to promote other vaccinations. Research should continue to compare vaccination experiences and how they may persuade or dissuade vaccination intent for other vaccinations.PMID:38461049 | DOI:10.1016/j.vaccine.2024.03.003 (Source: Vaccine)
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Monique Luisi Mugur V Geana Jun Pei Source Type: research
Safety and immunogenicity of heterologous boosting with a bivalent SARS-CoV-2 mRNA vaccine (XBB.1.5/BQ.1) in Chinese participants aged 18 years or more: A randomised, double-blinded, active-controlled phase 1 trial
In conclusion, SYS6006.32 showed good safety profile and superior immunogenicity to the monovalent vaccine SYS6006.PMID:38461050 | DOI:10.1016/j.vaccine.2024.03.005 (Source: Vaccine)
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Yu-Wen Su Yuan-Zheng Qiu Yuan-Hui Wang Yan Xu Chao-Chao Huang Qing Zhang Chang Su Jun-Heng Ma Wen Liu Yan Liu Mao-Sheng Zhao Han-Yu Yang Chun-Lei Li Xiang Lu Source Type: research
Current vaccine strategies and novel approaches to combatting Francisella infection
Vaccine. 2024 Mar 8:S0264-410X(24)00264-0. doi: 10.1016/j.vaccine.2024.02.086. Online ahead of print.ABSTRACTTularemia is caused by subspecies of Francisella tularensis and can manifest in a variety of disease states, with the pneumonic presentation resulting in the greatest mortality. Despite decades of research, there are no approved vaccines against F. tularensis in the United States. Traditional vaccination strategies, such as live-attenuated or subunit vaccines, are not favorable due to inadequate protection or safety concerns. Because of this, novel vaccination strategies are needed to combat tularemia. Here we discu...
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Jaikin E Harrell Chad J Roy John S Gunn James B McLachlan Source Type: research
Intranasal delivery of a self-adjuvanted nanovaccine composed of the curli filaments and the highly conserved M2e epitope confers protection against influenza a virus in mice
Vaccine. 2024 Mar 8:S0264-410X(24)00222-6. doi: 10.1016/j.vaccine.2024.02.063. Online ahead of print.ABSTRACTIntranasal administration of vaccines is an attractive delivery route to fight viral respiratory infections. However, there are only a few intranasal vaccines used in human, emphasizing the critical need to identify novel safe mucosal adjuvants and antigen delivery systems to expand their usage. We recently revealed an immunostimulating nanoparticle based on a fragment (R4R5) of the Curli-specific gene A (CsgA) protein that confers protection against influenza A virus (IAV) when conjugated to three repeats of the hi...
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Philippe St-Louis Cl ément Martin Vinay Khatri Steve Bourgault Denis Archambault Source Type: research
Vaccination during pregnancy and modulation of IgG response to pertussis vaccines in infants: The impact of different vaccine formulations
Vaccine. 2024 Mar 8:S0264-410X(24)00300-1. doi: 10.1016/j.vaccine.2024.03.015. Online ahead of print.ABSTRACTThe IgG response following infant diphtheria-tetanus-acellular pertussis (DTaP) immunization is influenced by the formulation of the infant and/or the adult vaccine (Tdap) given during pregnancy. DTaP vaccines containing either 3 (DTaP3) or 5 (DTaP5) pertussis antigens are commonly used. By conducting a secondary analysis of a large randomized controlled trial, we compared IgG levels against pertussis vaccine antigens in children of Td- and Tdap5-vaccinated mothers, after stratifying by infant vaccine formulation. A...
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Nicholas Brousseau Marie-Elen Angers-Goulet Robin Bastien Lingyun Ye Manish Sadarangani Scott A Halperin Source Type: research
Pandemic antecedents - Exploring predictivity and relationships between COVID-19 vaccine uptake and influenza, shingles, and HPV vaccination
CONCLUSION: Experience with COVID-19 vaccination and the relationship of those experiences with other vaccinations provide useful insight on leveraging vaccine uptake. Healthcare professionals should improve the COVID-19 vaccination experience and use vaccination appointments to promote other vaccinations. Research should continue to compare vaccination experiences and how they may persuade or dissuade vaccination intent for other vaccinations.PMID:38461049 | DOI:10.1016/j.vaccine.2024.03.003 (Source: Vaccine)
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Monique Luisi Mugur V Geana Jun Pei Source Type: research
Safety and immunogenicity of heterologous boosting with a bivalent SARS-CoV-2 mRNA vaccine (XBB.1.5/BQ.1) in Chinese participants aged 18 years or more: A randomised, double-blinded, active-controlled phase 1 trial
In conclusion, SYS6006.32 showed good safety profile and superior immunogenicity to the monovalent vaccine SYS6006.PMID:38461050 | DOI:10.1016/j.vaccine.2024.03.005 (Source: Vaccine)
Source: Vaccine - March 9, 2024 Category: Allergy & Immunology Authors: Yu-Wen Su Yuan-Zheng Qiu Yuan-Hui Wang Yan Xu Chao-Chao Huang Qing Zhang Chang Su Jun-Heng Ma Wen Liu Yan Liu Mao-Sheng Zhao Han-Yu Yang Chun-Lei Li Xiang Lu Source Type: research
