High-dose influenza vaccines for the prevention of hospitalization due to cardiovascular events in older adults in the nursing home: Post-hoc analysis of a cluster-randomized trial
Vaccine. 2022 Oct 13:S0264-410X(22)01215-4. doi: 10.1016/j.vaccine.2022.09.085. Online ahead of print.ABSTRACTOlder adults are at high risk of major acute cardiovascular events (MACE) linked to influenza illness andpreventable by influenza vaccination. It is unknown whether high-dose vaccine might incrementally reduce the risk of MACE.We conducted a post-hoc analysis of data collected from a pragmatic cluster randomized study of 823 nursing homes (NH) randomized to standard-dose (SD) or high-dose (HD) influenza vaccine in the 2013-14 season. Adults age 65 year or older who are Medicare-enrolled long-stay residents were inc...
Source: Vaccine - October 16, 2022 Category: Allergy & Immunology Authors: Elie A Saade Yasin Abul Kevin McConeghy H Edward Davidson Lisa Han Nina Joyce David H Canaday Leon Hsueh Elliott Bosco Stefan Gravenstein Source Type: research

The fight against poliomyelitis through the history: past, present and hopes for the future. Albert Sabin's missing Nobel and his "gift to all the world's children"
Vaccine. 2022 Oct 13:S0264-410X(22)01220-8. doi: 10.1016/j.vaccine.2022.09.088. Online ahead of print.ABSTRACTPolio, or poliomyelitis, is a disabling and life-threatening disease caused by three poliovirus (PV) serotypes. The virus spreads from person to person and can infect a person's spinal cord, causing paralysis. In 1988, when the WHO registered 350,000 cases of poliomyelitis in the world and 70,000 which occurred in Africa alone, global poliomyelitis eradication was proposed by the World Health Organization to its member States. On 25 August 2020, while the world was waging war against the Coronavirus pandemic, a his...
Source: Vaccine - October 16, 2022 Category: Allergy & Immunology Authors: Mariano Martini Davide Orsini Source Type: research

Interaction between anti-tick vaccine and a macrocyclic lactone improves acaricidal efficacy against Rhipicephalus (Boophilus) microplus (Canestrini) (Acari: Ixodidae) in experimentally infested cattle
Vaccine. 2022 Oct 13:S0264-410X(22)01230-0. doi: 10.1016/j.vaccine.2022.10.001. Online ahead of print.ABSTRACTThe southern cattle fever tick (SCFT) Rhipicephalus (Boophilus) microplus, is considered the most important ectoparasite of livestock in the world because of high financial losses associated with direct feeding and transmission of the hemoparasites Babesia bovis, B. bigemina, and Anaplasma marginale. Unfortunately, SCFT in many parts of the world have evolved resistance to all market-available pesticides thus driving development of new control technologies. Vaccination against ticks using the tick gut protein Bm86 ...
Source: Vaccine - October 16, 2022 Category: Allergy & Immunology Authors: Charluz M Arocho Rosario Robert J Miller Guilherme M Klafke Craig Coates William E Grant Grace Samenuk Kathleen Yeater Jason Tidwell Stephen Bach Adalberto A P érez de León Pete D Teel Source Type: research

Exploring the subnational inequality and heterogeneity of the impact of routine measles immunisation in Africa
Vaccine. 2022 Oct 13:S0264-410X(22)01157-4. doi: 10.1016/j.vaccine.2022.09.049. Online ahead of print.ABSTRACTDespite vaccination being one of the most effective public health interventions, there are persisting inequalities and inequities in immunisation. Understanding the differences in subnational vaccine impact can help improve delivery mechanisms and policy. We analyse subnational vaccination coverage of measles first-dose (MCV1) and estimate patterns of inequalities in impact, represented as deaths averted, across 45 countries in Africa. We also evaluate how much this impact would improve under more equitable vaccina...
Source: Vaccine - October 16, 2022 Category: Allergy & Immunology Authors: Susy Echeverria-Londono Anna-Maria Hartner Xiang Li Jeremy Roth Allison Portnoy Alyssa N Sbarra Kaja Abbas Matthew Ferrari Han Fu Mark Jit Neil M Ferguson Katy A M Gaythorpe Source Type: research

Catch-up immunisation for migrant children in Melbourne: A qualitative study with providers to determine key challenges
CONCLUSIONS: Key barriers for providers to deliver a comprehensive catch-up immunisation service were related to opportunity. Developing an online tool to support catch-up schedule development and reporting, and funding provider time to calculate the schedule are primary actions that could overcome opportunity barriers. Capability and motivation barriers for general practitioners included limited time, skills, and motivation compared to nurses. These barriers may be overcome with improvements to training that focus on upskilling nurses to deliver the catch-up service. Service delivery challenges are multifactorial, requiri...
Source: Vaccine - October 15, 2022 Category: Allergy & Immunology Authors: Isabella Overmars Jessica Kaufman Philippa Holland Margie Danchin Jane Tuckerman Source Type: research

A phase II, single-center, randomized, double-blind, parallel control clinical study evaluating the immunogenicity and safety of a two-dose schedule of serogroups ACYW meningococcal polysaccharide conjugate vaccine
CONCLUSION: The serogroups ACYW meningococcal polysaccharide conjugate vaccine was safe and effective in the population aged 3-35 months. The vaccine efficacy and safety of the 20-μg dose group were not less than that of the 40-μg dose group.PMID:36243590 | DOI:10.1016/j.vaccine.2022.08.001 (Source: Vaccine)
Source: Vaccine - October 15, 2022 Category: Allergy & Immunology Authors: Yi Mo Yanan Li Gang Liu Junji Chen Dingkai Wei Jigang Wu Qiuyan Meng Zhi Li Zhaojun Mo Source Type: research

Trends in HPV vaccine administration and HPV vaccine coverage in children by race/ethnicity and socioeconomic status during the COVID-19 pandemic in an integrated health care system in California
CONCLUSION: HPV vaccine promotion efforts are needed to address COVID-19 pandemic's lasting impact on HPV vaccination coverage.PMID:36243591 | DOI:10.1016/j.vaccine.2022.09.073 (Source: Vaccine)
Source: Vaccine - October 15, 2022 Category: Allergy & Immunology Authors: Chun R Chao Lanfang Xu Nancy Cannizzaro David Bronstein Yunsun Choi Robert Riewerts Brian Mittman Richard K Zimmerman Melissa Gilkey Beth Glenn Ernest Shen Chunyi Hsu Erin E Hahn Source Type: research

Transcutaneous immunization via dissolving microneedles protects mice from lethal influenza H7N9 virus challenge
Vaccine. 2022 Oct 12:S0264-410X(22)01102-1. doi: 10.1016/j.vaccine.2022.09.008. Online ahead of print.ABSTRACTAvian influenza H7N9 virus has first emerged in 2013 and since then has spread in China in five seasonal waves. In humans, influenza H7N9 virus infection is associated with a high fatality rate; thus, an effective vaccine for this virus is needed. In the present study, we evaluated the usefulness of dissolving microneedles (MNs) loaded with influenza H7N9 vaccine in terms of the dissolution time, insertion capacity, insertion depth, and structural integrity of H7N9 virus in vitro. Our in vitro results showed MNs di...
Source: Vaccine - October 15, 2022 Category: Allergy & Immunology Authors: Siqi Liu Guozhong Yang Minghui Li Fang Sun Yufeng Li Xiliang Wang Yunhua Gao Penghui Yang Source Type: research

Factors associated with pneumococcal vaccine uptake among vulnerable older adults in the United States primary care setting
This study assessed factors associated with having gotten a pneumococcal vaccine among vulnerable adults aged 50 and older. This study used the 2018 Medical Expenditure Panel Survey nationally representative dataset. Eligible individuals were aged 50-64 with an 'at risk' health condition or ≥65 years and had a primary care provider as their usual source of care (N = 3,760). Binary logistic regression was used to test factors (identified from literature) for a significant association with getting the pneumococcal vaccine. Factors with significant associations were entered into an adjusted multivariable logistic regression...
Source: Vaccine - October 13, 2022 Category: Allergy & Immunology Authors: Megan Whaley David R Axon Source Type: research

Factors associated with pneumococcal vaccine uptake among vulnerable older adults in the United States primary care setting
This study assessed factors associated with having gotten a pneumococcal vaccine among vulnerable adults aged 50 and older. This study used the 2018 Medical Expenditure Panel Survey nationally representative dataset. Eligible individuals were aged 50-64 with an 'at risk' health condition or ≥65 years and had a primary care provider as their usual source of care (N = 3,760). Binary logistic regression was used to test factors (identified from literature) for a significant association with getting the pneumococcal vaccine. Factors with significant associations were entered into an adjusted multivariable logistic regression...
Source: Vaccine - October 13, 2022 Category: Allergy & Immunology Authors: Megan Whaley David R Axon Source Type: research

Factors associated with pneumococcal vaccine uptake among vulnerable older adults in the United States primary care setting
This study assessed factors associated with having gotten a pneumococcal vaccine among vulnerable adults aged 50 and older. This study used the 2018 Medical Expenditure Panel Survey nationally representative dataset. Eligible individuals were aged 50-64 with an 'at risk' health condition or ≥65 years and had a primary care provider as their usual source of care (N = 3,760). Binary logistic regression was used to test factors (identified from literature) for a significant association with getting the pneumococcal vaccine. Factors with significant associations were entered into an adjusted multivariable logistic regression...
Source: Vaccine - October 13, 2022 Category: Allergy & Immunology Authors: Megan Whaley David R Axon Source Type: research

COVID-19 vaccine perceptions and hesitancy amongst parents of school-aged children during the pediatric vaccine rollout
CONCLUSION: Our study provides insight into determinants of vaccine acceptance, vaccine hesitancy, and trusted sources of information that may be helpful to develop targeted interventions to increase youth COVID-19 vaccination.PMID:36220714 | DOI:10.1016/j.vaccine.2022.09.090 (Source: Vaccine)
Source: Vaccine - October 11, 2022 Category: Allergy & Immunology Authors: Alexandra Byrne Lindsay A Thompson Stephanie L Filipp Kathleen Ryan Source Type: research

Scarier than the flu shot? : The social determinants of shingles and influenza vaccinations among U.S. older adults
CONCLUSION: The importance of social groups, health, and health behaviors on vaccination status may be disease-dependent. This study also provides possible guidance to health care providers and health organizations looking to increase vaccine uptake among older adults, which may have more urgency since the arrival of COVID-19.PMID:36220715 | DOI:10.1016/j.vaccine.2022.09.061 (Source: Vaccine)
Source: Vaccine - October 11, 2022 Category: Allergy & Immunology Authors: Eric M Vogelsang Andrea N Polonijo Source Type: research

Safety and immunogenicity of live, attenuated intranasal Bordetella pertussis vaccine (BPZE1) in healthy adults
DISCUSSION: Lyophilized BPZE1 vaccine was well tolerated and immunogenic at the highest dose (109 CFU) delivered intranasally by VaxINator device and was not associated with any SAEs or prolonged shedding of BPZE1. Further evaluation of BPZE1 is warranted.PMID:36220716 | DOI:10.1016/j.vaccine.2022.09.075 (Source: Vaccine)
Source: Vaccine - October 11, 2022 Category: Allergy & Immunology Authors: C Buddy Creech Natalia Jimenez-Truque Naomi Kown Katherine Sokolow Eric J Brady Sandra Yoder Ken Solovay Keith Rubin Stephanie Noviello Elizabeth Hensel Semhal Selamawi Adetunji Bakare Mat Makowski Kristina Lu Source Type: research

COVID-19 vaccine perceptions and hesitancy amongst parents of school-aged children during the pediatric vaccine rollout
CONCLUSION: Our study provides insight into determinants of vaccine acceptance, vaccine hesitancy, and trusted sources of information that may be helpful to develop targeted interventions to increase youth COVID-19 vaccination.PMID:36220714 | DOI:10.1016/j.vaccine.2022.09.090 (Source: Vaccine)
Source: Vaccine - October 11, 2022 Category: Allergy & Immunology Authors: Alexandra Byrne Lindsay A Thompson Stephanie L Filipp Kathleen Ryan Source Type: research