Hospitalizations of patients with herpes zoster in Poland during 2012-2021: A population-based study
CONCLUSIONS: The HZ-related number of hospitalizations and mortality in Poland are relatively low, but HZ is still a significant health problem. Risk factors include female gender, older age and residence in urban areas.PMID:38368221 | DOI:10.1016/j.vaccine.2024.02.022 (Source: Vaccine)
Source: Vaccine - February 17, 2024 Category: Allergy & Immunology Authors: Micha ł Rząd Krzysztof Kanecki Katarzyna Lewtak Piotr Tyszko Pawe ł Gorynski Aneta Nitsch-Osuch Source Type: research

2022 Polio outbreak, Rockland County, NY: Cost evaluation of strategies to prevent future outbreaks of vaccine-preventable diseases
Vaccine. 2024 Feb 16:S0264-410X(24)00171-3. doi: 10.1016/j.vaccine.2024.02.025. Online ahead of print.ABSTRACTIn 1994, the World Health Organization Region of the Americas was declared polio-free. In July 2022, a confirmed case of paralytic polio in an unvaccinated adult resident of Rockland County, New York was reported by the New York State Department of Health (NYSDOH) and Rockland County Department of Health (RCDOH). While only one case was identified, a single case of paralytic polio represents a public health emergency in the United States. The patient's county of residence was identified to have low vaccination cove...
Source: Vaccine - February 17, 2024 Category: Allergy & Immunology Authors: Jamison Pike James Lueken Julie Zajac Ashley Tippins Shani Doss Adina De Coteau Chitra Punjabi Maria Souto Achal Bhatt Source Type: research

Comparison of a static cohort model and dynamic transmission model for respiratory syncytial virus intervention programs for infants in England and Wales
CONCLUSIONS: Parameterization of the RSV mAb intervention efficacy is a plausible primary driver of differences between SCM versus DTM model predictions.PMID:38368224 | DOI:10.1016/j.vaccine.2024.02.004 (Source: Vaccine)
Source: Vaccine - February 17, 2024 Category: Allergy & Immunology Authors: John C Lang Klodeta Kura Salisu M Garba Elamin H Elbasha Yao-Hsuan Chen Source Type: research

Autoimmune hepatitis: Brighton Collaboration case definition and guidelines for data collection, analysis, and presentation of immunisation safety data
This report introduces a Brighton Collaboration (BC) case definition for autoimmune hepatitis (AIH), which has been classified as a priority adverse event of special interest (AESI), as there were possible cases seen following COVID-19 vaccination. The case definition was developed by a group of subject matter and BC process experts to facilitate safety data comparability across pre- and post-licensure clinical trials, as well as pharmacovigilance activities in multiple settings with diverse resources and healthcare access. The usual BC case definition development process was followed in an expedited manner, and took two m...
Source: Vaccine - February 17, 2024 Category: Allergy & Immunology Authors: Sonali Kochhar David N Assis Cara Mack Hector S Izurieta Luigi Muratori Alma Munoz Dale Nordenberg Jane F Gidudu Erin F Blau John M Vierling Source Type: research

Impact and cost-effectiveness analyses of vaccination for prevention of respiratory syncytial virus disease among older adults in Ontario: A Canadian Immunization Research Network (CIRN) study
CONCLUSIONS: Vaccinating residents of LTCHs against RSV disease would be cost-effective depending on PPD; extending the program to community-dwelling older adults would provide substantial health benefits, averting significant direct healthcare costs and productivity losses.PMID:38368226 | DOI:10.1016/j.vaccine.2024.02.041 (Source: Vaccine)
Source: Vaccine - February 17, 2024 Category: Allergy & Immunology Authors: Affan Shoukat Carolyn E Bawden Gergely R öst Jason J LeBlanc Alison P Galvani Joanne M Langley Seyed M Moghadas Source Type: research

COVID-19 vaccine perspectives and uptake among university students three years into the pandemic
CONCLUSIONS: The majority of university students agreed that COVID-19 vaccination is important and supported COVID-19 mandates. While the rate of fully vaccinated and up-to-date students was similar to the US adult population, the latter rate needs improvement. Receipt of the BA.4/BA.5 booster was particularly low. Further education is needed to improve vaccine knowledge, especially as we move to periodic boosters. Business majors, males, and younger students may benefit from increased on-campus vaccine education initiatives.PMID:38365478 | DOI:10.1016/j.vaccine.2024.02.015 (Source: Vaccine)
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Barbara J Kuter Kate Brien Susannah Anderson Sarah Bauerle Bass Linda Gutierrez Stella Winters Breanna Eichenlaub Carmelita Whitfield Walter Faig Source Type: research

Risk of SARS-CoV-2 breakthrough infection following NVX-CoV2373 and BNT162b2 vaccinations in Korean Adults: A population-based observational study
Vaccine. 2024 Feb 15:S0264-410X(24)00168-3. doi: 10.1016/j.vaccine.2024.02.021. Online ahead of print.ABSTRACTSouth Korea experienced a low prevalence of SARS-CoV-2 until the emergence of the omicron in early 2022, triggering a major community epidemic. To evaluate effectiveness of NVX-CoV2373 and BNT162b2 vaccines in Korean population, we conducted an observational study utilizing individual-level case data on laboratory-confirmed SARS-CoV-2 infection, along with vaccination record. A total of 47,078 recipients of NVX-CoV2373 vaccine and 7,561 recipients of BNT162b2 vaccine were eligible for the study. Thirty days post-se...
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Hee Kyoung Kim Seon Kyeong Park Seung Ah Choe Eun Sun Gwak Benjamin John Cowling Young-Man Kim Kil Hun Lee Sang Won Lee Geun-Yong Kwon Eun Jung Jang Ryu Kyung Kim Young June Choe Donghyok Kwon Source Type: research

Trend of measles-rubella vaccination coverage and impact on measles epidemiology in the Savannah Region, Ghana; 2018-2022: A secondary data analysis
CONCLUSIONS: The MR vaccination coverage in the Savannah Region declined probably due to pre-existing weaknesses in the immunization programme accentuated by impact of the COVID-19 pandemic. The lowered population immunity likely contributed to occurrence of the measles outbreak in 2022. Pragmatic actions are needed to catch-up on missed children, restore coverage to pre-pandemic levels, and strengthen the immunization programme as part of global efforts towards achieving the Immunization Agenda 2030 (IA2030) trajectory.PMID:38365480 | DOI:10.1016/j.vaccine.2024.02.024 (Source: Vaccine)
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Michael Rockson Adjei Amos Longsignikuu Ibrahim Saeed Iddris Thomas Nang Suuri Byrite Asamoah Michael Okoye Janet Vanessa Baafi Chrysantus Kubio Sally-Ann Ohene Martin Peter Grobusch Source Type: research

Deep sequencing and variant frequency analysis for the quality control of a live bacterial vaccine against contagious bovine pleuropneumonia, strain T1
Vaccine. 2024 Feb 15:S0264-410X(24)00177-4. doi: 10.1016/j.vaccine.2024.02.031. Online ahead of print.ABSTRACTVaccination is the most cost-effective tool to control contagious bovine pleuropneumonia. The vaccines currently used in Africa are derived from a live strain called T1, which was attenuated by passage in embryonated eggs and broth culture. The number of passages is directly correlated to the degree of attenuation of the vaccinal strains and inversely correlated to their immunogenicity in cattle. Current quality control protocols applied to vaccine batches allow the assessment of identity, purity, and titers, but c...
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Fran çois Thiaucourt Antoni Exbrayat Etienne Loire Anne Boissi ère Nick Nwankpa Luc ía Manso-Silván Source Type: research

Safety and immunogenicity of the NVX-CoV2373 vaccine as a booster in adults previously vaccinated with the BBIBP-CorV vaccine
Vaccine. 2024 Feb 15:S0264-410X(24)00196-8. doi: 10.1016/j.vaccine.2024.02.037. Online ahead of print.ABSTRACTThis phase 3 observer-blind, randomized, controlled study was conducted in adults ≥18 years of age to assess the safety and immunogenicity of NVX-CoV2373 as a heterologous booster compared to BBIBP-CorV when utilized as a homologous booster. Approximately 1000 participants were randomly assigned in a 1:1 ratio to receive a single dose of NVX-CoV2373 or BBIBP-CorV after prior vaccination with 2 or 3 doses of BBIBP-CorV. Solicited adverse events (AEs) were collected for 7 days after vaccination. Unsolicited AEs wer...
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Seth Toback Anthony M Marchese Brandy Warren Sondos Ayman Senka Zarkovic Islam ElTantawy Raburn M Mallory Matthew Rousculp Fahed Almarzooqi Bartlomiej Piechowski-Jozwiak Maria-Fernanda Bonilla Agyad Ebrahim Bakkour Salah Eldin Hussein Nawal Al Kaabi Source Type: research

Vaccine effectiveness against COVID-19: A test negative case-control study in Tunisia, August 2021
CONCLUSION: The results of our study showed that the anti-Covid-19 vaccines used in Tunisia are efficient to prevent both SARS-COV-2 infections and severe forms related to the disease. This study provided important data on the performance of vaccines in real-world settings that guide decisions about vaccine sustained use.PMID:38365483 | DOI:10.1016/j.vaccine.2024.02.028 (Source: Vaccine)
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Emna Mziou Aicha Hchaichi Hejer Letaief Sonia Dhaouadi Mouna Safer Khouloud Talmoudi Rim Mhadhbi Nawel Elmili Leila Bouabid Sondes Derouiche Souha Bougatef Hedia Bellali Nissaf Bouafif Ép Ben Alaya Source Type: research

A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies
Vaccine. 2024 Feb 16:S0264-410X(24)00175-0. doi: 10.1016/j.vaccine.2024.02.029. Online ahead of print.ABSTRACTPlasmodium vivax malaria is increasingly recognized as a major global health problem and the socio-economic impact of P.vivax-induced burden is huge. Vaccine development against P. vivax malaria has been hampered by the lack of an in vitro culture system and poor access to P. vivax sporozoites. The recent generation of Plasmodium falciparum parasites that express a functional P. vivax AMA1 molecule has provided a platform for in vitro evaluation of PvAMA1 as a potential blood stage vaccine. Three so-called PvAMA1 D...
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Bart W Faber Lee M Yeoh Liriye Kurtovic Wim E M Mol Martin Poelert Elly Smits Roberto Rodriguez Garcia Marjolein Mandalawi-Van der Eijk Nicole van der Werff Annemarie Voorberg-van der Wel Edmond J Remarque James G Beeson Clemens H M Kocken Source Type: research

Immunogenicity and safety of a SARS-CoV-2 mRNA vaccine (SYS6006) in healthy Chinese participants: A randomized, observer-blinded, placebo-controlled phase 2 clinical trial
In conclusion, two-dose vaccination with SYS6006 demonstrated good safety, tolerability and immunogenicity in immunologically naïve healthy participants aged 18 years or more.PMID:38365485 | DOI:10.1016/j.vaccine.2024.01.098 (Source: Vaccine)
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Fei Jin Yuanzheng Qiu Zhiwei Wu Yuan-Hui Wang Chengye Cai Liangcai Fu Wenbin Jiao Huixian Wang Ming Gao Chang Su Jun-Heng Ma Yan Xu Chao-Chao Huang Qing Zhang Shaonan Ni Maosheng Zhao Lixian Guo Li Ji Hanyu Yang Yuliang Zhao Chunlei Li Xiang Lu Yu-Wen Su Source Type: research

Celebrating vaccines: The 2023 Nobel prize in medicine or physiology
Vaccine. 2024 Feb 15:S0264-410X(23)01258-6. doi: 10.1016/j.vaccine.2023.10.056. Online ahead of print.NO ABSTRACTPMID:38365486 | DOI:10.1016/j.vaccine.2023.10.056 (Source: Vaccine)
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Gregory A Poland C Raina MacIntyre Source Type: research

Shiga toxin type 2 B subunit protects mice against toxin challenge when leashed and bundled by a stable pentameric coiled-coil molecule
Vaccine. 2024 Feb 15:S0264-410X(24)00129-4. doi: 10.1016/j.vaccine.2024.01.102. Online ahead of print.ABSTRACTVaccines against Shiga toxin (Stx)-producing Escherichia coli (STEC) have not yet been developed. Two immunologically distinct serotypes of Stx (Stx1 and Stx2) are the main virulence factors of STEC. Thus, blocking their B subunits (StxB) from binding to the cell surface receptor globotriaosylceramide (Gb3) efficiently prevents the action of these toxins. We expressed Stx1B and Stx2B in E. coli inclusion bodies and reassembled them into pentamers by a stepwise dialysis. Stx1B pentamer fully protected mice against S...
Source: Vaccine - February 16, 2024 Category: Allergy & Immunology Authors: Yukihiro Tamaki Tetsuya Harakuni Takeshi Arakawa Source Type: research