Association of pathological response with long-term survival outcomes after neoadjuvant immunotherapy: A meta-analysis
CONCLUSION: Our meta-analysis demonstrates a strong association between pathological response and long-term survival outcomes at patient level across studies applying neoadjuvant immunotherapy in most solid tumors but we fail to validate the relationship at trial level. Therefore, an accepted surrogate endpoint applied to both patient and trial levels are waited for further search.PMID:38685176 | DOI:10.1016/j.intimp.2024.112078 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Chenyu Wei Haolin Sun Jiexuan Hu Zhongjun Ma Bangwei Cao Source Type: research
The immune cells in modulating osteoclast formation and bone metabolism
Int Immunopharmacol. 2024 Apr 28;133:112151. doi: 10.1016/j.intimp.2024.112151. Online ahead of print.ABSTRACTOsteoclasts are pivotal in regulating bone metabolism, with immune cells significantly influencing both physiological and pathological processes by modulating osteoclast functions. This is particularly evident in conditions of inflammatory bone resorption, such as rheumatoid arthritis and periodontitis. This review summarizes and comprehensively analyzes the research progress on the regulation of osteoclast formation by immune cells, aiming to unveil the underlying mechanisms and pathways through which diseases, su...
Source: International Immunopharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Jiale Hong Fang Luo Xingyue Du Fa Xian Xinyi Li Source Type: research
Clinical role of NDRG2-based methylation status on survival pattern of glioblastoma
CONCLUSION: Current findings highlight the importance of studying DNA methylation of NDRG2 as a key factor to understand the role of epigenetic alterations in GBM.PMID:38686946 | DOI:10.1177/03946320241250294 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Menha Swellam Mohamed K Khalifa Amira M Nageeb Lobna Ezz El-Arab Manal El-Mahdy Khaled El-Bahy Magda Sayed Mahmoud Source Type: research
A novel immune cell signature for predicting glioblastoma after radiotherapy prognosis and guiding therapy
Conclusion: The immune cell signature, comprising SDC-1, PLAUR, FN1, and CXCL13, holds promise as a predictive tool for assessing glioblastoma prognosis following radiotherapy. This signature also offers valuable guidance for tailoring treatment strategies, emphasizing its potential clinical relevance in improving patient outcomes.PMID:38687369 | DOI:10.1177/03946320241249395 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Rong Huang Xiaoxu Lu Xueming Sun Hui Wu Source Type: research
Early response to Tezepelumab in type-2 severe asthma patients non-responders to other biological treatments: a real-life study
CONCLUSION. In real-world scenarios, despite the study's limitations, our results underscore Tezepelumab's promise as a therapeutic option for uncontrolled severe asthma, and may be useful for non-responders to other mAbs. Further studies are needed to corroborate these findings.PMID:38686823 | DOI:10.1080/02770903.2024.2349605 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Miguel Jim énez-Gómez Roc ío Magdalena Díaz-Campos Álvaro Gimeno-Díaz-De-Atauri Consuelo Fern ández-Rodríguez Jes ús Fernández-Crespo Ismael Garc ía-Moguel Source Type: research
A Meta-Analysis Investigating the Efficacy and Safety of Allergen-Specific Immunotherapy in the Management of Respiratory Allergies
Conclusion: The results of our meta-analysis suggest that specific immunotherapy, while associated with some adverse effects, effectively reduces the symptoms of asthma and rhinitis. Therefore, we recommend its use in the treatment of respiratory allergies.PMID:38687911 | DOI:10.1080/02770903.2024.2349604 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Xue Li Juju Shang Jian Liu Yong Zhu Source Type: research
Deciphering Cuproptosis-related Signatures in Pediatric Allergic Asthma using Integrated scRNA-seq and Bulk RNA-seq Analysis
Conclusion This work provided a machine learning model containing five important variables, which may have good diagnostic efficiency for pediatric AA.PMID:38687912 | DOI:10.1080/02770903.2024.2349596 (Source: Journal of Asthma)
Source: Journal of Asthma - April 30, 2024 Category: Respiratory Medicine Authors: Jingping Liu Yujia Sun Chunxin Tian Dong Qin Lanying Gao Source Type: research
FG-4592 protected haematopoietic system from ionising radiation in mice
Immunology. 2024 Apr 29. doi: 10.1111/imm.13797. Online ahead of print.ABSTRACTIonising radiation exposure can lead to acute haematopoietic radiation syndrome. Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG-4592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG-4592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apopt...
Source: Immunology - April 30, 2024 Category: Allergy & Immunology Authors: Yuedong Wang Ying Cheng Pei Zhang Daqian Huang Xuanlu Zhai Zhenlan Feng Duo Fang Cong Liu Jicong Du Jianming Cai Source Type: research
A novel immune ‑related lncRNA as a prognostic biomarker in HER2 < sup > + < /sup > breast cancer
Oncol Lett. 2024 Apr 16;27(6):269. doi: 10.3892/ol.2024.14402. eCollection 2024 Jun.ABSTRACTHuman epidermal growth factor receptor 2 (HER2)+ breast cancer is characterized by high malignancy and poor prognosis. Long non-coding (lnc)RNAs are crucial in breast cancer progression and prognosis, especially in tumor-associated immune processes. The present study aimed to elucidate novel lncRNAs related to immune function that could serve as biomarkers for both diagnosis and prognosis of this cancer subtype. Using data from The Cancer Genome Atlas and The Immunology Database and Analysis Portal, correlation analysis was performe...
Source: Oncology Letters - April 30, 2024 Category: Cancer & Oncology Authors: Xinwei Li Yue Meng Bing Gu Source Type: research
Factors Influencing Iatrogenic Skin Injury in Neonates and Nursing Strategies
CONCLUSION: Length of stay, orotracheal intubation use, and gastric tube use are independent risk factors for iatrogenic skin injury in neonates. Hospital stays and unnecessary use of orotracheal intubation and gastric tube should be reduced in future clinical management. Attention should be paid to strengthening skin observation and care, keeping skin dry and clean, and preventing iatrogenic skin injury.PMID:38687850 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Huifang Deng Chunhua Li Nuo Yu Source Type: research
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF- κB Signaling Pathway and Inflammatory Response [Corrigendum]
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 30, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
GSE246792 Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APP swe and PS1 dE9 mutations
Contributors : Guilherme Juvenal ; Carine Meinerz ; Ana C Ayupe ; Henrique C Campos ; Eduardo M Reis ; Beatriz M Longo ; Micheli M Pillat ; Henning UlrichSeries Type : Expression profiling by arrayOrganism : Mus musculusNeural stem cells (NSCs) can be cultivated from developing brains, reproducing many of the processes that occur during neural development. They can be isolated from a variety of animal models, such as transgenic mice carrying mutations in amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN 1 and 2), characteristic of familial Alzheimer ’s Disease (AD). Modulating the development of these cells...
Source: GEO: Gene Expression Omnibus - April 30, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
The Safety of Ixekizumab in Chinese Adults with Moderate-to-Severe Plaque Psoriasis: Analyses from a Prospective, Single-Arm, Multicenter, 12-Week Observational Study
ConclusionsIn this real-world study, ixekizumab was well tolerated in Chinese patients with moderate-to-severe plaque psoriasis, with no difference in safety across most patient subgroups. (Source: Drug Safety)
Source: Drug Safety - April 30, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluation of the “Burgenland PREvention trial of colorectal cancer Disease with ImmunologiCal Testing” (B-PREDICT)—a population-based colorectal cancer screening program
The colorectal cancer (CRC) screening program B-PREDICT is a population based invited two stage screening project using a faecal immunochemical test (FIT) for initial screening followed by a colonoscopy for th... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 30, 2024 Category: Gastroenterology Authors: Stefanie BREZINA, Gernot LEEB, Andreas BAIERL, Evelyn GR ÄF, Monika HACKL, Philipp HOFER, Harald LANG, Michaela KLEIN, Karl MACH, Remy SCHWARZER, Wilhelm WLASSITS, Andreas PÜSPÖK and Andrea GSUR Tags: Research Source Type: research
