Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint

Mul è et al. provide a framework for integrating human population and single-cell variations to study vaccine responses with and without the adjuvant AS03. They uncover AS03-specific B cell survival and innate-sensing signatures 1 day after vaccination. Furthermore, some AS03-induced response cell st ates are already present at baseline in "naturally adjuvanted" individuals who respond more robustly serologically to the unadjuvanted vaccine.

Source: Immunity - May 1, 2024 Category: Allergy & Immunology Authors: Matthew P. Mul è, Andrew J. Martins, Foo Cheung, Rohit Farmer, Brian A. Sellers, Juan A. Quiel, Arjun Jain, Yuri Kotliarov, Neha Bansal, Jinguo Chen, Pamela L. Schwartzberg, John S. Tsang Tags: Resource Source Type: research