A novel rat robot controlled by electrical stimulation of the nigrostriatal pathway.
In this study, the authors aimed to electrically stimulate the NSP of conscious rats to build a command-prompt rat robot. METHODS: Repetitive NSP stimulation at 1-second intervals was applied via implanted electrodes to induce immediate contraversive turning movements in 7 rats in open field tests in the absence of any sensory cues or rewards. The rats were manipulated to navigate from the start arm to a target zone in either the left or right arm of a T-maze. A leftward trial was followed by a rightward trial, and each rat completed a total of 10 trials. In the control group, 7 rats were tested in the same way withou...
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Koh CS, Park HY, Shin J, Kong C, Park M, Seo IS, Koo B, Jung HH, Chang JW, Shin HC Tags: Neurosurg Focus Source Type: research

Letter to the Editor. Surgical logbooks in neurosurgery: a simple way to enhance training.
PMID: 32610287 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Hegde A Tags: Neurosurg Focus Source Type: research

Gamma-band modulation in the human amygdala during reaching movements.
CONCLUSIONS: To the authors' knowledge, this is the first time that direct neural recordings have been used to show gamma-band modulation in the human amygdala during the execution of voluntary movement. This work indicates that gamma-band modulation in the amygdala could be a contributing source of neural signals for use in a motor BCI system. PMID: 32610288 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Gogia AS, Martin Del Campo-Vera R, Chen KH, Sebastian R, Nune G, Kramer DR, Lee MB, Tafreshi AR, Barbaro MF, Liu CY, Kellis S, Lee B Tags: Neurosurg Focus Source Type: research

Investigation of stereotactic surgery for avian brain stimulation by a fully implanted wireless system.
CONCLUSIONS: The authors were able to implant the entire brain stimulation system inside the avian body without any surgical complications. Postoperative observations suggested that the bird did not find the implant uncomfortable. PMID: 32610289 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Baek C, Kim S, Jang JW, Jung Y, Choi GJ, Shim S, Yun S, Seo K, Song YK, Kim SJ, Seo JM Tags: Neurosurg Focus Source Type: research

The current state of electrocorticography-based brain-computer interfaces.
Abstract Brain-computer interfaces (BCIs) provide a way for the brain to interface directly with a computer. Many different brain signals can be used to control a device, varying in ease of recording, reliability, stability, temporal and spatial resolution, and noise. Electrocorticography (ECoG) electrodes provide a highly reliable signal from the human brain surface, and these signals have been used to decode movements, vision, and speech. ECoG-based BCIs are being developed to provide increased options for treatment and assistive devices for patients who have functional limitations. Decoding ECoG signals in real...
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Miller KJ, Hermes D, Staff NP Tags: Neurosurg Focus Source Type: research

A systematic review of endovascular stent-electrode arrays, a minimally invasive approach to brain-machine interfaces.
CONCLUSIONS: Endovascular stent-electrode arrays provide a minimally invasive approach to BMIs. Stent-electrode placement has been shown to be both efficacious and safe, although further data are necessary to draw comparisons between subdural and epidural electrode measurements given the heterogeneity of the studies included. Greater access to deep-seated brain regions is now more feasible with stent-electrode arrays; however, further validation is needed in large clinical trials to optimize this neural interface. This includes the determination of ideal electrode material type, venous versus arterial approaches, the feasi...
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Soldozy S, Young S, Kumar JS, Capek S, Felbaum DR, Jean WC, Park MS, Syed HR Tags: Neurosurg Focus Source Type: research

Introduction. Exploring neurosurgical innovations at the brain-machine interface.
PMID: 32610292 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Miller KJ, Pouratian N, Chang JW, Lee KH Tags: Neurosurg Focus Source Type: research

MRI and tractography techniques to localize the ventral intermediate nucleus and dentatorubrothalamic tract for deep brain stimulation and MR-guided focused ultrasound: a narrative review and update.
Abstract The thalamic ventral intermediate nucleus (VIM) can be targeted for treatment of tremor by several procedures, including deep brain stimulation (DBS) and, more recently, MR-guided focused ultrasound (MRgFUS). To date, such targeting has relied predominantly on coordinate-based or atlas-based techniques rather than directly targeting the VIM based on imaging features. While general regional differences of features within the thalamus and some related white matter tracts can be distinguished with conventional imaging techniques, internal nuclei such as the VIM are not discretely visualized. Advanced imaging...
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Lehman VT, Lee KH, Klassen BT, Blezek DJ, Goyal A, Shah BR, Gorny KR, Huston J, Kaufmann TJ Tags: Neurosurg Focus Source Type: research

Optimizing the neuron-electrode interface for chronic bioelectronic interfacing.
Abstract Engineering approaches have vast potential to improve the treatment of disease. Brain-machine interfaces have become a well-established means of treating some otherwise medically refractory neurological diseases, and they have shown promise in many more areas. More widespread use of implanted stimulating and recording electrodes for long-term intervention is, however, limited by the difficulty in maintaining a stable interface between implanted electrodes and the local tissue for reliable recording and stimulation.This loss of performance at the neuron-electrode interface is due to a combination of inflam...
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Keogh C Tags: Neurosurg Focus Source Type: research

Habenula deep brain stimulation for intractable schizophrenia: a pilot study.
Abstract Schizophrenia is a psychiatric disorder associated with significant morbidity and mortality. Although antipsychotic medications and electroconvulsive therapy can be used to manage the clinical symptoms of schizophrenia, a substantial portion (10%-30%) of patients do not clinically respond to these treatments or cannot tolerate the side effects. Recently, deep brain stimulation (DBS) has emerged as a promising safe and effective therapeutic intervention for various psychiatric disorders. Here, the authors explore the utility of DBS of the habenula (HB) in the clinical management of 2 young adult male patie...
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Wang Y, Zhang C, Zhang Y, Gong H, Li J, Jin H, Li D, Liu D, Sun B Tags: Neurosurg Focus Source Type: research

Hippocampal CA1 and CA3 neural recording in the human brain: validation of depth electrode placement through high-resolution imaging and electrophysiology.
CONCLUSIONS: This study demonstrates the ability to record neurons in vivo from specified regions and subfields of the human brain. As brain-machine interface and neural prosthetic research continues to expand, it is necessary to be able to identify recording and stimulation sites within neural circuits of interest. PMID: 32610296 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Wicks RT, Witcher MR, Couture DE, Laxton AW, Popli G, Whitlow CT, Fetterhoff D, Dakos AS, Roeder BM, Deadwyler SA, Hampson RE Tags: Neurosurg Focus Source Type: research

Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation.
Abstract The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of neurostimulation therapies. Despite the highly dynamic nature of neurological diseases, open-loop DBS applications are incapable of modifying parameters in real time to react to fluctuations in disease states. Thus, current practice for the designation of stimulation parameters, such as duration, amplitude, and pulse frequency, is an algorithmic process. Ideal stimulation parameters are highly individualized and must reflect both the specific disease presen...
Source: Neurosurgical Focus - July 1, 2020 Category: Neurosurgery Authors: Price JB, Rusheen AE, Barath AS, Rojas Cabrera JM, Shin H, Chang SY, Kimble CJ, Bennet KE, Blaha CD, Lee KH, Oh Y Tags: Neurosurg Focus Source Type: research

Real-life analysis of 280 patients with surgically treated acromegaly: a single-center experience from 2008 to 2015.
CONCLUSIONS: The data underline the effectiveness of MTS in acromegaly. Many patients with recurrent disease or incomplete tumor resection can be successfully managed pharmacologically. PMID: 32480363 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Rotermund R, Mader MM, Burkhardt T, Matschke J, Aberle J, Krajewski K, Flitsch J, Rahvar AH Tags: Neurosurg Focus Source Type: research

Machine learning-based prediction of outcomes of the endoscopic endonasal approach in Cushing disease: is the future coming?
CONCLUSIONS: ML algorithms were used to train and internally validate robust models for all the endpoints, giving accurate outcome predictions in CD cases. This analytical method seems promising for potentially improving future patient care and counseling; however, careful clinical interpretation of the results remains necessary before any clinical adoption of ML. Moreover, further studies and increased sample sizes are definitely required before the widespread adoption of ML to the study of CD. PMID: 32480364 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Zoli M, Staartjes VE, Guaraldi F, Friso F, Rustici A, Asioli S, Sollini G, Pasquini E, Regli L, Serra C, Mazzatenta D Tags: Neurosurg Focus Source Type: research

Editorial. Machine learning and artificial intelligence applied to the diagnosis and management of Cushing disease.
PMID: 32480365 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Laws ER, Catalino MP Tags: Neurosurg Focus Source Type: research

Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly.
CONCLUSIONS: Endoscopic transsphenoidal resection of GH-secreting pituitary adenomas is a safe and highly effective treatment for achieving hormonal remission and tumor control in up to 87% of patients with acromegaly when combined with postoperative medical therapy. Patients with lower preoperative IGF-1 and POD1 GH levels, with less invasive pituitary adenomas, and who undergo GTR are more likely to achieve postoperative biochemical remission. PMID: 32480366 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Cardinal T, Rutkowski MJ, Micko A, Shiroishi M, Jason Liu CS, Wrobel B, Carmichael J, Zada G Tags: Neurosurg Focus Source Type: research

Genomic and molecular characterization of pituitary adenoma pathogenesis: review and translational opportunities.
CONCLUSIONS: Although not currently a prominent aspect in the clinical management of pituitary adenomas, genomics and epigenomic studies may become essential in refining patient care and developing novel pharmacological agents. Future basic science investigations should aim at elucidating mechanistic understandings unique to each pituitary adenoma subtype, which will facilitate rational drug design. PMID: 32480367 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Elsarrag M, Patel PD, Chatrath A, Taylor D, Jane JA Tags: Neurosurg Focus Source Type: research

Development and validation of the disease-specific QOL-CD quality of life questionnaire for patients with Cushing's disease.
Abstract OBJECTIVE: Cushing's disease (CD) patients experience a range of debilitating symptoms that impair quality of life (QOL) as assessed using generic measures. These generic measures are inadequate to capture the disease-specific burden of illness. The development of the CD-specific QOL-CD measure of QOL using items generated by CD patients and healthcare professionals will provide a holistic assessment of patient outcomes and efficacy of novel therapies. METHODS: A total of 96 CD patients participated. A list of 177 items (version 1.0) was generated by treated CD patients (n = 9), caregivers (n = 2), h...
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Cusimano MD, Huang TQ, Marchie A, Smyth HS, Kovacs K Tags: Neurosurg Focus Source Type: research

Prior smoking and nasoseptal flap usage adversely impact quality of life and healing after endoscopic pituitary surgery.
The objective of this study was to determine the relationship between key patient and operative variables and rhinological outcomes as determined by the 22-item Sino-Nasal Outcome Test (SNOT-22) and endoscopic scores following EPS. METHODS: Prospectively collected SNOT-22 scores and objective endoscopic data were analyzed from a cohort of 109 patients who underwent EPS and had at least 90 days of postoperative follow-up. Trends in postoperative SNOT-22 scores were analyzed using linear mixed-effects models. Time to return to baseline endoscopic score was analyzed using Cox regression. RESULTS: After adjusting for...
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Shay A, Sturgis M, Ritz EM, Beer-Furlan A, Muñoz L, Byrne R, Tajudeen BA, Batra PS Tags: Neurosurg Focus Source Type: research

Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution.
Abstract OBJECTIVE: Nonfunctioning pituitary adenomas present without biochemical or clinical signs of hormone excess and are the second most common type of pituitary adenomas. The 2017 WHO classification scheme of pituitary adenomas differentiates null-cell adenomas (NCAs) and silent gonadotroph adenomas (SGAs). The present study sought to highlight the differences in patient characteristics and clinical outcomes between NCAs and SGAs. METHODS: The records of 1166 patients who underwent transsphenoidal surgery for pituitary adenoma between 2012 and 2019 at a single institution were retrospectively reviewed. ...
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK Tags: Neurosurg Focus Source Type: research

Repair of the sellar floor using bioresorbable polydioxanone foils after endoscopic endonasal pituitary surgery.
CONCLUSIONS: The described technique is an easy, inexpensive, and reliable method for sellar floor reconstruction and has a low CSF leakage rate. It is recommended when the risk of a postoperative CSF leak is high and there is still enough bony margin of the sellar floor left that enables a sufficient fixation of the foil. PMID: 32480371 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Zeden JP, Baldauf J, Schroeder HWS Tags: Neurosurg Focus Source Type: research

Introduction. Management of pituitary tumors: 2020 and beyond.
PMID: 32480372 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Zada G, Schroeder HWS, Little AS, Laws ER Tags: Neurosurg Focus Source Type: research

Digital analysis of hormonal immunostaining in pituitary adenomas classified according to WHO 2017 criteria and correlation with preoperative laboratory findings.
Abstract OBJECTIVE: The authors sought to evaluate clinical and laboratory data from pituitary adenoma (PA) patients with functioning PA (associated with acromegaly [n = 10] or Cushing disease [n = 10]) or nonfunctioning PA (NFPA; n = 10) that were classified according to 2017 WHO criteria (based on the expression of the transcription factors pituitary-specific positive transcription factor 1 [Pit-1], a transcription factor member of the T-box family [Tpit], and steroidogenic factor 1 [SF-1]) and to assess the immunostaining results for growth hormone (GH) and adrenocorticotropic hormone (ACTH) in the correspondin...
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Tamanini JVG, Dal Fabbro M, de Freitas LLL, Vassallo J, de Souza Queiroz L, Rogerio F Tags: Neurosurg Focus Source Type: research

Optimizing pre-, intra-, and postoperative management of patients with sellar pathology undergoing transsphenoidal surgery.
CONCLUSIONS: Patients with sellar lesions who undergo transsphenoidal surgery require complex, multidisciplinary perioperative care to monitor for common adverse events and to improve outcomes, but there is a dearth of high-quality evidence guiding most perioperative practices. Here, the authors reviewed practices at their institution across more than 1000 transsphenoidal operations that may help ensure successful patient outcomes. PMID: 32480374 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Cote DJ, Iuliano SL, Catalino MP, Laws ER Tags: Neurosurg Focus Source Type: research

Does pituitary compression/empty sella syndrome contribute to MRI-negative Cushing's disease? A single-institution experience.
CONCLUSIONS: Empty sella syndrome is associated with an increased rate of MRI-negative Cushing's disease. Pituitary compression causing a relative reduction in the volume of the pituitary for imaging is a plausible cause for not detecting the tumor mass with MRI. PMID: 32480375 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Himes BT, Bhargav AG, Brown DA, Kaufmann TJ, Bancos I, Van Gompel JJ Tags: Neurosurg Focus Source Type: research

Ten years' experience with intraoperative MRI-assisted transsphenoidal pituitary surgery.
ľa A Abstract OBJECTIVE: Many innovations have been introduced into pituitary surgery in the quest to maximize the extent of tumor resection. Because of the deep and narrow surgical corridor as well as the heterogeneity of confronted pathologies, anatomical orientation and identification of the target tissue can become difficult. Intraoperative MRI (iMRI) may have the potential to increase extent of resection (EOR) in transsphenoidal pituitary surgery. Furthermore, it may simplify anatomical orientation and risk assessment in difficult cases. Here, the authors evaluated the additional value of iMRI for the resect...
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Hlaváč M, Knoll A, Mayer B, Braun M, Karpel-Massler G, Etzrodt-Walter G, Coburger J, Wirtz CR, Paľa A Tags: Neurosurg Focus Source Type: research

Assessing the surgical outcome of the "chopsticks" technique in endoscopic transsphenoidal adenoma surgery.
CONCLUSIONS: This study shows that the chopsticks technique confers resection and morbidity results that compare favorably with literature reports of TSS. This technique permits a single surgeon to perform effective endoscopic bimanual dissection through a single nostril, reducing manipulation of healthy tissue and thereby possibly minimizing surgical morbidity. PMID: 32480377 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Serra C, Staartjes VE, Maldaner N, Holzmann D, Soyka MB, Gilone M, Schmid C, Tschopp O, Regli L Tags: Neurosurg Focus Source Type: research

Surgical outcomes and multidisciplinary management strategy of Cushing's disease: a single-center experience in China.
CONCLUSIONS: MRI-visible microadenoma and primary surgery were independent predictors of surgical remission in CD. The MDT management strategy helps to achieve a better overall outcome. BIPSS may help to lateralize the tumor in MRI-negative/equivocal microadenomas. PMID: 32480378 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Zhang K, Shen M, Qiao N, Chen Z, He W, Ma Z, Shou X, Li S, Zhao Y, Pan L, Liu D, He M, Zhang Z, Li Y, Yao Z, Ye H, Wang Y Tags: Neurosurg Focus Source Type: research

PET-guided repeat transsphenoidal surgery for previously deemed unresectable lateral disease in acromegaly.
CONCLUSIONS: This study provides proof of concept that Met-PET/MRCR can be helpful in the evaluation of residual lateral sellar/parasellar disease in persistent acromegaly and facilitate targeted revision TSS in a subgroup of patients. PMID: 32480379 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - June 1, 2020 Category: Neurosurgery Authors: Bashari WA, Senanayake R, Koulouri O, Gillett D, MacFarlane J, Powlson AS, Fernandez-Pombo A, Bano G, Martin AJ, Scoffings D, Cheow H, Mendichovszky I, Tysome J, Donnelly N, Santarius T, Kolias A, Mannion R, Gurnell M Tags: Neurosurg Focus Source Type: research

Introduction. Evolution of the Science of Practice.
PMID: 32357318 [PubMed - as supplied by publisher] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Harbaugh RE, Asher AL, Cockroft KM, Knightly J, Narenthiran G Tags: Neurosurg Focus Source Type: research

Erratum. The T2-FLAIR-mismatch sign as an imaging biomarker for IDH and 1p/19q status in diffuse low-grade gliomas: a systematic review with a Bayesian approach to evaluation of diagnostic test performance.
PMID: 32357319 [PubMed - as supplied by publisher] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Goyal A Tags: Neurosurg Focus Source Type: research

Quality Outcomes Database Spine Care Project 2012-2020: milestones achieved in a collaborative North American outcomes registry to advance value-based spine care and evolution to the American Spine Registry.
Abstract The Quality Outcomes Database (QOD), formerly known as the National Neurosurgery Quality Outcomes Database (N2QOD), was established by the NeuroPoint Alliance (NPA) in collaboration with relevant national stakeholders and experts. The overarching goal of this project was to develop a centralized, nationally coordinated effort to allow individual surgeons and practice groups to collect, measure, and analyze practice patterns and neurosurgical outcomes. Specific objectives of this registry program were as follows: "1) to establish risk-adjusted national benchmarks for both the safety and effectiveness ...
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Asher AL, Knightly J, Mummaneni PV, Alvi MA, McGirt MJ, Yolcu YU, Chan AK, Glassman SD, Foley KT, Slotkin JR, Potts EA, Shaffrey ME, Shaffrey CI, Haid RW, Fu KM, Wang MY, Park P, Bisson EF, Harbaugh RE, Bydon M Tags: Neurosurg Focus Source Type: research

Correlation of return to work with patient satisfaction after surgery for lumbar spondylolisthesis: an analysis of the Quality Outcomes Database.
Abstract OBJECTIVE: Return to work (RTW) and satisfaction are important outcome measures after surgery for degenerative spine disease. The authors queried the prospective Quality Outcomes Database (QOD) to determine if RTW correlated with patient satisfaction. METHODS: The QOD was queried for patients undergoing surgery for degenerative lumbar spondylolisthesis. The primary outcome of interest was correlation between RTW and patient satisfaction, as measured by the North American Spine Society patient satisfaction index (NASS). Secondarily, data on satisfied patients were analyzed to see what patient factors ...
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: DiGiorgio AM, Mummaneni PV, Park P, Chan AK, Bisson EF, Bydon M, Foley KT, Glassman SD, Shaffrey CI, Potts EA, Shaffrey ME, Coric D, Knightly JJ, Wang MY, Fu KM, Asher AL, Virk MS, Kerezoudis P, Alvi MA, Guan J, Haid RW, Slotkin JR Tags: Neurosurg Focus Source Type: research

Vasopressor treatment and mortality following nontraumatic subarachnoid hemorrhage: a nationwide electronic health record analysis.
CONCLUSIONS: In patients with nontraumatic SAH, phenylephrine was significantly associated with reduced mortality in SAH patients compared to dopamine or norepinephrine. Prospective randomized clinical studies are warranted to confirm this finding. PMID: 32357322 [PubMed - as supplied by publisher] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Williams G, Maroufy V, Rasmy L, Brown D, Yu D, Zhu H, Talebi Y, Wang X, Thomas E, Zhu G, Yaseen A, Miao H, Leon Novelo L, Zhi D, DeSantis SM, Zhu H, Yamal JM, Aguilar D, Wu H Tags: Neurosurg Focus Source Type: research

Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics.
CONCLUSIONS: The authors established the feasibility of SCI CDE implementation in a multicenter, prospective observational study. Through the application of standardized SCI CDEs and expansion of future multicenter collaborations, they hope to advance SCI research and improve treatment. PMID: 32357323 [PubMed - as supplied by publisher] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Haefeli J, Weinstein PR, de Almeida Neto CA, K Tags: Neurosurg Focus Source Type: research

How the science of practice will improve evidence-based care.
Abstract This review article analyzes the present evidence-based medicine (EBM) algorithm, compares it to the science of practice (SOP) algorithm, and demonstrates how the SOP can evolve from a quality assurance and quality improvement tool into a clinical research tool. Using appropriately constructed prospective observational databases (PODs), the SOP algorithm can be used to draw causal inferences from nonrandomized data, perform innovative comparative effectiveness research, and generate reliable information that can be used to guide treatment decisions. PMID: 32357324 [PubMed - as supplied by publisher] ...
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Harbaugh RE Tags: Neurosurg Focus Source Type: research

The embedded biases in hypothesis testing and machine learning.
PMID: 32357325 [PubMed - as supplied by publisher] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Habboub G, Grabowski MM, Kelly ML, Benzel EC Tags: Neurosurg Focus Source Type: research

Letter to the Editor. The T2-FLAIR-mismatch sign.
PMID: 32357326 [PubMed - as supplied by publisher] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Jain R Tags: Neurosurg Focus Source Type: research

Editorial. Reflections on the first decade of neurosurgical science of practice: what has been accomplished; what ambitions remain to be fulfilled?
PMID: 32357327 [PubMed - as supplied by publisher] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - May 1, 2020 Category: Neurosurgery Authors: Asher AL, Bydon M, Harbaugh RE Tags: Neurosurg Focus Source Type: research

Unilateral prefrontal lobotomy for epilepsy: technique and surgical anatomy.
CONCLUSIONS: This technique allows selective isolation of the epileptogenic focus located in the prefrontal lobe to avoid secondary propagation. Understanding the surface and white matter fiber anatomy is essential to safely perform the procedure and obtain a favorable seizure outcome. PMID: 32234977 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Cossu G, González-López P, Pralong E, Kalser J, Messerer M, Daniel RT Tags: Neurosurg Focus Source Type: research

Introduction. Surgical treatment of epilepsy.
PMID: 32234978 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: McKhann GM, McEvoy AW, Gross RE, Chabardes S Tags: Neurosurg Focus Source Type: research

Risk factors and results of hemispherotomy reoperations in children.
CONCLUSIONS: Patients with malformations of cortical development have a higher risk of seizure recurrence, and these malformations comprised the main etiology in the reoperation series. Failure of an initial hemispherotomy usually occurs due to incomplete disconnection and needs to be extensively assessed. Outcomes of reoperation are most often favorable, with acceptable complication rates. PMID: 32234979 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Volpon Santos M, Teixeira TL, Ioriatti ES, Thome U, Paula de Andrade Hamad A, Machado HR Tags: Neurosurg Focus Source Type: research

Cavernoma-related epilepsy in cavernous malformations located within the temporal lobe: surgical management and seizure outcome.
CONCLUSIONS: Favorable seizure outcome is achievable in a substantial number of patients with epileptogenic CCM located in the temporal lobe, even if patients suffered from drug-resistant CRE. For adequate counseling and monitoring, patients with CRE should undergo a thorough pre- and postsurgical evaluation in dedicated epilepsy surgery programs. PMID: 32234980 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Schuss P, Marx J, Borger V, Brandecker S, Güresir Á, Hadjiathanasiou A, Hamed M, Schneider M, Surges R, Vatter H, Güresir E Tags: Neurosurg Focus Source Type: research

Letter to the Editor. Lumbar canal stenosis: can "only fixation" really make decompression futile?
Letter to the Editor. Lumbar canal stenosis: can "only fixation" really make decompression futile? Neurosurg Focus. 2020 Apr 01;48(4):E19 Authors: Rahman A PMID: 32234981 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Rahman A Tags: Neurosurg Focus Source Type: research

Interneuron transplantation: a prospective surgical therapy for medically refractory epilepsy.
Abstract Excitatory-inhibitory imbalance is central to epilepsy pathophysiology. Current surgical therapies for epilepsy, such as brain resection, laser ablation, and neurostimulation, target epileptic networks on macroscopic scales, without directly correcting the circuit-level aberrations responsible for seizures. The transplantation of inhibitory cortical interneurons represents a novel neurobiological method for modifying recipient neural circuits in a physiologically corrective manner. Transplanted immature interneurons have been found to disperse in the recipient brain parenchyma, where they develop elaborat...
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Harward SC, Southwell DG Tags: Neurosurg Focus Source Type: research

Robot-assisted stereoelectroencephalography exploration of the limbic thalamus in human focal epilepsy: implantation technique and complications in the first 24 patients.
CONCLUSIONS: Using judiciously planned robot-assisted SEEG, the authors demonstrate the safety of electrophysiological sampling from various thalamic nuclei for research recordings, presenting a technique that avoids implanting additional depth electrodes or compromising clinical care. With these results, we propose that if patients are fully informed of the risks involved, there are potential benefits of gaining mechanistic insights to seizure genesis, which may help to develop neuromodulation therapies. PMID: 32234983 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Chaitanya G, Romeo AK, Ilyas A, Irannejad A, Toth E, Elsayed G, Bentley JN, Riley KO, Pati S Tags: Neurosurg Focus Source Type: research

Safety of the paramedian supracerebellar-transtentorial approach for selective amygdalohippocampectomy.
CONCLUSIONS: The PST approach is a reproducible and safe surgical route for SA. The achievable complication rate is in line with the best results in the literature. Visual function outcome particularly benefits from this highly selective, neocortex-sparing approach. A larger patient sample and longer follow-up will show in the future if the seizure control rate and neuropsychological outcome also compare better than those achieved with current common surgical techniques. PMID: 32234984 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Serra C, Akeret K, Staartjes VE, Ramantani G, Grunwald T, Jokeit H, Bauer J, Krayenbühl N Tags: Neurosurg Focus Source Type: research

Editorial. Dulling the double-edged sword of human SEEG research.
PMID: 32234985 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: McKhann GM Tags: Neurosurg Focus Source Type: research

Cingulate gyrus epilepsy: semiology, invasive EEG, and surgical approaches.
CONCLUSIONS: In this study, the authors exploited the improved access to the cingulate epileptogenic network made possible by the use of 3D electrodes implanted using stereoelectroencephalography methodology. Under iEEG recording and intraoperative neuromonitoring, epilepsy surgery on lesions in the cingulate gyrus can result in good outcomes in terms of seizure recurrence and the incidence of postoperative permanent deficits. PMID: 32234986 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Chou CC, Lee CC, Lin CF, Chen YH, Peng SJ, Hsiao FJ, Yu HY, Chen C, Chen HH, Shih YH Tags: Neurosurg Focus Source Type: research

Pediatric functional hemispherectomy: operative techniques and complication avoidance.
In this report, the authors summarize the history of hemispherectomy and its development and present a graphical guide for this anatomically challenging procedure. The use of the osteoplastic flap to improve outcome and the management of hydrocephalus are discussed. PMID: 32234987 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - April 1, 2020 Category: Neurosurgery Authors: Young CC, Williams JR, Feroze AH, McGrath M, Ravanpay AC, Ellenbogen RG, Ojemann JG, Hauptman JS Tags: Neurosurg Focus Source Type: research