Diagnosis and Management of Hypothyroidism in Gulf Cooperation Council (GCC) Countries
AbstractHypothyroidism is one of the most common chronic endocrine conditions. However, as symptoms of hypothyroidism are non-specific, up to 60% of those with thyroid dysfunction are unaware of their condition. Left untreated, hypothyroidism may contribute to other chronic health conditions. In the Arabian Gulf States, hypothyroidism is thought to be common, but is underdiagnosed, and management approaches vary. An advisory board of leading Saudi endocrinologists and policy advisers was convened to discuss and formulate recommendations for the diagnosis and management of hypothyroidism in Saudi Arabia based on their clini...
Source: Advances in Therapy - June 1, 2020 Category: Drugs & Pharmacology Source Type: research

Papillary Thyroid Cancer —Aggressive Variants and Impact on Management: A Narrative Review
ConclusionThese aggressive variants should be known by clinicians, to avoid underdiagnosis, and treated according to the latest recommendations in the literature. (Source: Advances in Therapy)
Source: Advances in Therapy - June 1, 2020 Category: Drugs & Pharmacology Source Type: research

Antimicrobial De-Escalation in the ICU: From Recommendations to Level of Evidence
AbstractAntimicrobial de-escalation (ADE) is a component of antimicrobial stewardship (AMS) aimed to reduce exposure to broad-spectrum antimicrobials. In the intensive care unit, ADE is a strong recommendation that is moderately applied in clinical practice. Following a systematic review of the literature, we assessed the studies identified on the topic which included one randomized controlled trial and 20 observational studies. The literature shows a low level of evidence, although observational studies suggested that this procedure is safe. The effects of ADE on the level of resistance of ecological systems and especiall...
Source: Advances in Therapy - May 27, 2020 Category: Drugs & Pharmacology Source Type: research

Benefits of Tiotropium/Olodaterol Compared with Tiotropium in Patients with COPD Receiving only LAMA at Baseline: Pooled Analysis of the TONADO ® and OTEMTO ® Studies
AbstractIntroductionThe Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy report recommends long-acting muscarinic antagonists (LAMA) or long-acting β2-agonists (LABA) as first-line treatment for chronic obstructive pulmonary disease (COPD), but many patients remain symptomatic on monotherapy and escalation to dual-bronchodilator therapy may be warranted.MethodsTONADO® 1&2 and OTEMTO® 1&2 assessed lung function and patient-reported outcomes in patients with moderate-to-severe (OTEMTO) or moderate-to-very-severe (TONADO) COPD. This pooled post hoc analysis included patients treated ...
Source: Advances in Therapy - May 27, 2020 Category: Drugs & Pharmacology Source Type: research

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3 –11 Years with Hepatitis C Genotype 1a
ConclusionThe mini-tablet combination of OBV, PTV, ritonavir, and DSV plus ribavirin to treat HCV GT1a infection for 12  weeks was highly effective and suitable in children 3–11 years of age.Trial RegistrationClinicalTrials.gov identifier, NCT02486406. (Source: Advances in Therapy)
Source: Advances in Therapy - May 25, 2020 Category: Drugs & Pharmacology Source Type: research

Prevalence and Management Challenges in Central Post-Stroke Neuropathic Pain: A Systematic Review and Meta-analysis
ConclusionsClinicians should look for any evidence of central neuropathic pain for at least 12  months after stroke. Both pharmacological and non-pharmacological interventions can be used for the management of CPSP. Lamotrigine has the strongest evidence (Level II of evidence, derived from small randomized controlled trials) for being effective in the management of CPSP. Future research sho uld focus on well-designed trials of pharmacological and non-pharmacological interventions aiming to relief CPSP, which is a very common but often neglected pain syndrome. (Source: Advances in Therapy)
Source: Advances in Therapy - May 23, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Panel Discussion: Some Aspects of the Management of Patients with X-Linked Hypophosphataemic Rickets
In the original article, third author name has been published incorrectly. (Source: Advances in Therapy)
Source: Advances in Therapy - May 23, 2020 Category: Drugs & Pharmacology Source Type: research

Best Practice Approach to Successful Conversion of Fosaprepitant to Aprepitant IV in a Large Multisite Community Oncology Infusion Center: A Retrospective Analysis
ConclusionSuccessful conversion to aprepitant, and specifically to a 2-min IV push, provides time, cost, and resource savings, improves operational efficiency, and avoids the negative impact of potential future IV fluid shortages. (Source: Advances in Therapy)
Source: Advances in Therapy - May 23, 2020 Category: Drugs & Pharmacology Source Type: research

The Burden of Progressive Fibrosing Interstitial Lung Disease: A DELPHI Approach
ConclusionsProgression in fibrosing ILD causes a significant impact on QoL and HCRU and costs. These survey data underline the need for safe and effective therapies to slow the disease progression. (Source: Advances in Therapy)
Source: Advances in Therapy - May 22, 2020 Category: Drugs & Pharmacology Source Type: research

The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review
AbstractEpigenetic processes are essential for normal development and the maintenance of tissue-specific gene expression in mammals. Changes in gene expression and malignant cellular transformation can result from disruption of epigenetic mechanisms, and global disruption in the epigenetic landscape is a key feature of cancer. The study of epigenetics in cancer has revealed that human cancer cells harbor both genetic alterations and epigenetic abnormalities that interplay at all stages of cancer development. Unlike genetic mutations, epigenetic aberrations are potentially reversible through epigenetic therapy, providing a ...
Source: Advances in Therapy - May 22, 2020 Category: Drugs & Pharmacology Source Type: research

Etrolizumab for the Treatment of Ulcerative Colitis and Crohn ’s Disease: An Overview of the Phase 3 Clinical Program
DiscussionThe etrolizumab phase  3 clinical program is the largest and most comprehensive in inflammatory bowel disease, enrolling more than 3000 patients. The program explores both induction and maintenance regimens. HIBISCUS I and II and GARDENIA are among the first head-to-head trials in UC against an anti-TNF and are the fir st registrational trials making that comparison. This program will also help address unanswered clinical questions on evaluation of treatment effects and treatment selection across a range of patients with varying treatment histories using an extensive repository of patient samples and da...
Source: Advances in Therapy - May 22, 2020 Category: Drugs & Pharmacology Source Type: research

Healthcare Resources Utilization and Costs of Patients with Non-IPF Progressive Fibrosing Interstitial Lung Disease Based on Insurance Claims in the USA
ConclusionsThese findings suggest higher disease severity and overall healthcare use for patients with a non-IPF ILD manifesting a progressive fibrosing phenotype (non-IPF PF-ILD). (Source: Advances in Therapy)
Source: Advances in Therapy - May 21, 2020 Category: Drugs & Pharmacology Source Type: research

Persistence of Inflammation After Uncomplicated Cataract Surgery: A 6-Month Laser Flare Photometry Analysis
AbstractPurposeTo evaluate, by laser photometry, the persistency of anterior chamber flare after uneventful phacoemulsification in asymptomatic patients with no signs of inflammation on slit lamp examination.MethodSeventy-five patients previously enrolled in a randomized clinical trial that evaluated inflammation after uneventful phacoemulsification in eyes treated with dexamethasone 0.1% ophthalmic suspension (group  1) or bromfenac 0.09% ophthalmic solution (group 2) for 2 weeks. Anterior chamber inflammation was investigated by laser flare photometry. At 30 days after surgery, laser flare showed pers...
Source: Advances in Therapy - May 21, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics and Dialyzability of a Single Oral Dose of Amenamevir, an Anti-Herpes Drug, in Hemodialysis Patients
ConclusionThere were no clinically relevant safety concerns when 400  mg of amenamevir was administered as a single dose to hemodialysis patients without dose adjustment and/or modification of the dosing schedule.Trial RegistrationJapicCTI-184242. (Source: Advances in Therapy)
Source: Advances in Therapy - May 21, 2020 Category: Drugs & Pharmacology Source Type: research

Incidence of Pericardial Effusion in Patients with Advanced Non-Small Cell Lung Cancer Receiving Immunotherapy
ConclusionOur findings confirm pericardial effusion as a relatively frequent side effect of immunotherapy in NSCLC. Clinicians should be aware of this specific toxicity in patients with metastatic NSCLC receiving immunotherapy and refer to a cardiologist for a multidisciplinary approach. (Source: Advances in Therapy)
Source: Advances in Therapy - May 20, 2020 Category: Drugs & Pharmacology Source Type: research

Treatment Patterns Among Patients with Multiple Sclerosis Initiating Second-Line Disease-Modifying Therapy
ConclusionsAmong patients with MS who switched DMTs, persistence was consistently low regardless of treatment. Although persistence with oral DMTs was slightly higher than with injectable DMTs, overall results indicate poor persistence to second-line therapy and highlight the need to improve long-term persistence with DMTs. (Source: Advances in Therapy)
Source: Advances in Therapy - May 20, 2020 Category: Drugs & Pharmacology Source Type: research

Development and Validation of a Nomogram-Based Prognostic Evaluation Model for Sarcomatoid Hepatocellular Carcinoma
ConclusionThe proposed four-factor nomogram of PEM could accurately predict the prognosis of SHC and could be used in clinical practice. (Source: Advances in Therapy)
Source: Advances in Therapy - May 20, 2020 Category: Drugs & Pharmacology Source Type: research

Treatment of Oculoplastic and Ocular Surface Disease in Eyes Implanted with a Type  I Boston Keratoprosthesis in Southern China: A Retrospective Study
ConclusionThe ocular environment is critical for successful KPro surgery. A multidisciplinary approach for any lid and ocular surface abnormality in ocular burns or Stevens –Johnson syndrome is important to improve the quality of the ocular surface and accommodate KPro and AGV, which is vital for maintaining vision after KPro surgery. FP8 AGV may be feasible for IOP control in adult KPro cases with restricted subconjunctival space. (Source: Advances in Therapy)
Source: Advances in Therapy - May 20, 2020 Category: Drugs & Pharmacology Source Type: research

Correction to: Sulodexide in the Treatment of Chronic Venous Insufficiency: Results of the All-Russian Multicenter ACVEDUCT Program
In the original article, there is some error in the Table  2. The correct Table 2 is given below. (Source: Advances in Therapy)
Source: Advances in Therapy - May 18, 2020 Category: Drugs & Pharmacology Source Type: research

Comparative Efficacy of Cabozantinib and Regorafenib for Advanced Hepatocellular Carcinoma
ConclusionsCabozantinib may achieve similar OS and prolonged PFS compared with regorafenib in patients with progressive advanced HCC after prior sorafenib. (Source: Advances in Therapy)
Source: Advances in Therapy - May 18, 2020 Category: Drugs & Pharmacology Source Type: research

Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Acetylsalicylic Acid in Fixed-Dose Combination with Clopidogrel Versus Enteric Aspirin in Chinese Subjects Under Fasting Conditions: A Phase  1, Open-Label, Randomized, Crossover Study
ConclusionApplication of the reference-scaled average bioequivalence approach to evaluate bioequivalence of acetylsalicylic acid in Chinese male and female healthy volunteers under fasting conditions demonstrated bioequivalence of test and reference formulations.Trial RegistrationCTR20181695. (Source: Advances in Therapy)
Source: Advances in Therapy - May 16, 2020 Category: Drugs & Pharmacology Source Type: research

Dual Antiplatelet Therapy Duration in Medically Managed Acute Coronary Syndrome Patients: Sub-Analysis of the OPT-CAD Study
AbstractIntroductionOptimal dual antiplatelet therapy (DAPT) duration for medically managed acute coronary syndrome (ACS) (MMACS) patients is still unknown. We explored the efficacy and safety of  ≥ 12-month DAPT among MMACS patients.MethodsIn this sub-analysis of the optimal antiplatelet therapy for Chinese Patients with Coronary Artery Disease study (NCT01735305), clinical outcomes among MMACS patients were compared between the  
Source: Advances in Therapy - May 16, 2020 Category: Drugs & Pharmacology Source Type: research

Preoperative Versus Extended Postoperative Antimicrobial Prophylaxis of Surgical Site Infection During Spinal Surgery: A Comprehensive Systematic Review and Meta-Analysis
ConclusionPreoperative AMP appears to provide equivalent protection against SSI development when compared to extended postoperative AMP. Prudent antibiotic use is also known to decrease hospital length of stay, healthcare expenditure, and risk of complications. However, until higher-quality evidence becomes available regarding AMP in spinal surgery, surgeons should continue to exercise discretion and clinical judgment when weighing the effects of patient comorbidities and complications before determining the optimal duration of perioperative AMP. (Source: Advances in Therapy)
Source: Advances in Therapy - May 15, 2020 Category: Drugs & Pharmacology Source Type: research

The Relationship Between White Adipose Tissue Inflammation and Overweight/Obesity in Chinese Female Breast Cancer: A Retrospective Study
ConclusionOverweight/obese breast cancer patients may be more prone to breast WAT inflammation and may be associated with abnormalities in circulatory markers associated with metabolic syndrome. (Source: Advances in Therapy)
Source: Advances in Therapy - May 15, 2020 Category: Drugs & Pharmacology Source Type: research

Comparing Physician and Patient Perspectives on Prophylactic Treatment with BAY  94-9027 for Severe Haemophilia A: A Post Hoc Analysis
ConclusionInterviewed physicians and patients generally agreed on the beneficial impact of BAY  94-9027, specifically regarding the increased level of self-confidence in patients and its subsequent positive impact on patients’ lives. These findings supported the observed improvement on the Haemo-QoL-A emotional impact subscale. Overall, this study highlights the concordance between physici an and patient perspective on the positive experience with BAY 94-9027. (Source: Advances in Therapy)
Source: Advances in Therapy - May 14, 2020 Category: Drugs & Pharmacology Source Type: research

Pattern of Laboratory Parameters and Management of Secondary Hyperparathyroidism in Countries of Europe, Asia, the Middle East, and North America
ConclusionsWide international variation in mineral and bone disorder laboratory parameters and management practices related to secondary hyperparathyroidism suggests opportunities for optimizing care. (Source: Advances in Therapy)
Source: Advances in Therapy - May 14, 2020 Category: Drugs & Pharmacology Source Type: research

Real-World Treatment Patterns, Adverse Events, Resource Use, and Costs Among Commercially Insured, Younger Patients with Chronic Lymphocytic Leukemia in the USA: A Retrospective Cohort Study
ConclusionThis study highlights the treatment toxicity and associated economic burden among patients with CCL in the USA. As novel therapies are increasingly used, further research examining outcomes will inform the risks, benefits, and value of novel agents to prescribers and patients. (Source: Advances in Therapy)
Source: Advances in Therapy - May 12, 2020 Category: Drugs & Pharmacology Source Type: research

Healthcare Resource Use and Costs Associated with Opioid Initiation Among Patients with Newly Diagnosed Endometriosis with Commercial Insurance in the USA
AbstractIntroductionTo compare all-cause and endometriosis-related healthcare resource utilization (HCRU) and healthcare costs by service categories (outpatient, inpatient, emergency room [ER], pharmacy) among patients with newly diagnosed endometriosis using opioids compared to patients with endometriosis not using opioids.MethodsA retrospective analysis of IBM ® MarketScan® Commercial Claims data from 2009 to 2018 was performed for women aged 18–49 with newly diagnosed endometriosis (International Classification of Diseases (ICD)-9 code 617.xx; ICD-10 code N80.xx) over 24 months follow-up. Patients wer...
Source: Advances in Therapy - May 12, 2020 Category: Drugs & Pharmacology Source Type: research

Micronized Purified Flavonoid Fraction in Hemorrhoid Disease: A Systematic Review and Meta-Analysis
AbstractIntroductionHemorrhoidal disease (HD) is a common and recurrent problem for many adults worldwide. Venoactive drugs, such as micronized purified flavonoid fraction (MPFF; Daflon®), have been used to treat HD and their clinical benefits have been demonstrated in previous meta-analyses of clinical trials. The aim of this study was to evaluate the efficacy of MPFF across the broader spectrum of signs and symptoms following treatment of patients with HD.MethodsWe performed a systematic review of the literature to identify randomized clinical trials in which MPFF treatment was compared to placebo or no treatment for...
Source: Advances in Therapy - May 12, 2020 Category: Drugs & Pharmacology Source Type: research

Consensus Recommendations for Management and Counseling of Adverse Events Associated With Lorlatinib: A Guide for Healthcare Practitioners
This article provides guidance to advanced practice providers (e.g., nurses, nurse practitioners, physician assistants) and oncology pharmacists for the clinical management of key lorlatinib-emergent adverse reactions (i.e., hyperlipidemias, central nervous system effects, bodyweight increase, edema, and peripheral neuropathy). As lorlatinib is both a substrate and inducer of the CYP3A enzyme system and is contraindicated with strong CYP3A inducers, relevant drug-drug interactions are also highlighted. (Source: Advances in Therapy)
Source: Advances in Therapy - May 12, 2020 Category: Drugs & Pharmacology Source Type: research

Identification of Patient Needs and Preferences in Pigmented Villonodular Synovitis (PVNS) Using a Qualitative Online Bulletin Board Study
ConclusionPVNS patients expressed an urgent need for a medical drug treatment, which can reduce pain, avoid relapses and provide an alternative to surgery, the current standard of care. (Source: Advances in Therapy)
Source: Advances in Therapy - May 11, 2020 Category: Drugs & Pharmacology Source Type: research

Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review
AbstractThis review focuses on pathogenesis of endometriosis, its possible biomarkers and role in endometriosis-associated ovarian cancer. We analyzed various databases to obtain new insights, theories, and biomarkers associated with endometriosis. There are several theories of endometriosis development and biomarker changes including atypical forms. A number of studies have attempted to establish specific, reliable biomarkers to help diagnose endometriosis and endometriosis-associated diseases on the basis of different pathogenetic pathways. Nevertheless, despite intensive research extending even to the molecular level, t...
Source: Advances in Therapy - May 8, 2020 Category: Drugs & Pharmacology Source Type: research

Lenvatinib and Subsequent Therapy for Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A Real-World Study of Clinical Effectiveness in the United States
ConclusionsIn this first real-world examination of clinical effectiveness of 1L lenvatinib and subsequent therapy among patients in the US, the results demonstrated that treatment with 1L lenvatinib followed by another 2L therapy may deliver a clinical benefit, thus allowing a number of potential 2L options following 1L lenvatinib for patients with RAI-r DTC. (Source: Advances in Therapy)
Source: Advances in Therapy - May 7, 2020 Category: Drugs & Pharmacology Source Type: research

A Phase II Study of Modified FOLFOX6 for Advanced Gastric Cancer Refractory to Standard Therapies
ConclusionModified FOLFOX6  (mFOLFOX6) showed substantial activity and acceptable toxicity for chemotherapy-refractory advanced gastric cancer.Trial RegistrationUMIN Clinical Trial Registry (UMIN000016416). (Source: Advances in Therapy)
Source: Advances in Therapy - May 7, 2020 Category: Drugs & Pharmacology Source Type: research

Cetuximab Maintenance Therapy in Patients with Unresectable Wild-Type RAS and BRAF Metastatic Colorectal Cancer: A Single-Institute Prospective Study
AbstractIntroductionCetuximab plus FOLFIRI (leucovorin, fluorouracil, and irinotecan) is the preferred first-line therapy for RAS and BRAF wild-type (RBWT) metastatic colorectal cancer (mCRC). To counter chemotherapy-induced side effects, use of maintenance therapy is suggested. Therefore, we evaluated the efficacy and safety of cetuximab maintenance therapy in patients after effective completion of first-line induction therapy.MethodsThis prospective study enrolled untreated patients with mCRC RBWT who received first-line cetuximab plus FOLFIRI therapy. Following this, patients with treatment response either entered obser...
Source: Advances in Therapy - May 7, 2020 Category: Drugs & Pharmacology Source Type: research

Secukinumab Use in Patients with Moderate to Severe Psoriasis, Psoriatic Arthritis and Ankylosing Spondylitis in Real-World Setting in Europe: Baseline Data from SERENA Study
ConclusionBaseline demographics of the study population are consistent with existing literature. This large observational study across all secukinumab indications will provide valuable information on the long-term effectiveness and safety of secukinumab in the real-world setting. (Source: Advances in Therapy)
Source: Advances in Therapy - May 6, 2020 Category: Drugs & Pharmacology Source Type: research

Limited Utility for Benzodiazepines in Chronic Pain Management: A Narrative Review
ConclusionsBZRAs are often used inappropriately in pain management. Their initiation and duration of use should be limited to a narrow range of conditions. When prescribed for 4  weeks or more, patients should be encouraged to discontinue them through a supported, slow tapering process that may take 12–18 months or longer. (Source: Advances in Therapy)
Source: Advances in Therapy - May 6, 2020 Category: Drugs & Pharmacology Source Type: research

Qualitative Interviews to Better Understand the Patient Experience and Evaluate Patient-Reported Outcomes (PRO) in RLBP1 Retinitis Pigmentosa ( RLBP1 RP)
ConclusionsVisual impairment due toRLBP1 RP has a substantial impact on physical functioning and daily activities. To adequately assess all important symptoms and associated functional impacts inRLBP1 RP, it is recommended to either modify one or more existing instruments or to develop a new non-syndromic RP specific instrument. (Source: Advances in Therapy)
Source: Advances in Therapy - May 5, 2020 Category: Drugs & Pharmacology Source Type: research

Pooled Safety and Tolerability Analysis of Empagliflozin in Patients with Type 2 Diabetes Mellitus
AbstractIntroductionThe aim of this analysis was to characterize the safety and tolerability of empagliflozin in patients with type 2 diabetes mellitus (T2DM) who were randomized to empagliflozin (10/25  mg) or placebo in clinical trials.MethodsPooled data from 20 trials were analyzed for patients with T2DM treated with empagliflozin 10  mg (n = 4858), empagliflozin 25 mg (n = 5057), or placebo (n = 4904). The dataset comprised 15 randomized phase I–III trials, an extension trial and dose escalation studies. Adverse events (AEs) were assessed descriptively in p...
Source: Advances in Therapy - May 5, 2020 Category: Drugs & Pharmacology Source Type: research

A Novel Nomogram Integrated with Inflammation-Based Factors to Predict the Prognosis of Gastric Cancer Patients
AbstractIntroductionGastric cancer (GC) is the fifth most common cancer worldwide, and every year approximately 950,000 individuals are diagnosed worldwide. Our study aimed to establish an effective nomogram to predict the prognosis of GC based on inflammation biomarkers.MethodsWe retrospectively analysed GC patients from the Sun Yat-sen University Cancer Center. The nomogram was developed with a primary cohort (n = 1067), and 537 patients were included in the validation cohort. The univariate survival analyses included 19 biomarkers.ResultsThe multivariate analysis showed that tumour stage, metastasis stage and C-reactive...
Source: Advances in Therapy - May 3, 2020 Category: Drugs & Pharmacology Source Type: research

Advances in Clinical Cardiology 2019: A Summary of Key Clinical Trials
ConclusionThis article presents key clinical trials completed during 2019 and should be valuable to clinicians and researchers working in cardiology. (Source: Advances in Therapy)
Source: Advances in Therapy - May 2, 2020 Category: Drugs & Pharmacology Source Type: research

Persistence and Adherence to ICS/LABA Drugs in UK Patients with Asthma: A Retrospective New-User Cohort Study
We describe real-world use of ICS/LABAs by comparing treatment persistence and adherence among patients with asthma in the United Kingdom initiating fluticasone furoate/vilanterol (FF/VI) versus budesonide/formoterol (BUD/FM) or beclometasone dipropionate/formoterol (BDP/FM).MethodsA retrospective new-user active comparator database study was conducted in the IQVIA Medical Research Database. Propensity score (PS) matching was performed for FF/VI versus BUD/FM, and FF/VI versus BDP/FM. The primary objective was to compare patient treatment persistence (time to discontinuation), while secondary objectives included assessing ...
Source: Advances in Therapy - May 2, 2020 Category: Drugs & Pharmacology Source Type: research

Anti COVID-19 Drugs: Need for More Clinical Evidence and Global Action
AbstractThe World Health Organization (WHO) called the outbreak of coronavirus infectious disease-2019 (COVID-19) a “Public Health Emergency of International Concern” (PHEIC). According to the WHO, Centers for Disease Control and Prevention (CDC), and the US Food and Drug Administration (FDA), currently there are no medicines or vaccines that have been claimed to be useful in the prevention or treatment of CO VID-19. Several existing antiviral drugs, previously developed or used as treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), human immunodeficiency virus (HIV...
Source: Advances in Therapy - April 29, 2020 Category: Drugs & Pharmacology Source Type: research

Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials
ConclusionHigher compared to standard doses of NAIs or systemic peramivir therapy compared to oral oseltamivir therapy did not demonstrate benefit. (Source: Advances in Therapy)
Source: Advances in Therapy - April 28, 2020 Category: Drugs & Pharmacology Source Type: research

Relevant Patient Benefit of Sublingual Immunotherapy with Birch Pollen Allergen Extract in Allergic Rhinitis: An Open, Prospective, Non-Interventional Study
ConclusionAfter 1  year of birch pollen SLIT treatment, patients reported considerable benefit, mainly due to a reduction of physical symptoms and treatment burden. (Source: Advances in Therapy)
Source: Advances in Therapy - April 28, 2020 Category: Drugs & Pharmacology Source Type: research

Prognostic Potential of Electrocardiographic Parameters in Patients with Multiple Myeloma: A Retrospective Analysis of the Multiple Myeloma Population
This study retrospectively included patients with MM from January 2010 to December 2018 in the First Affiliated Hospital of Xi ’an Jiao Tong University. Univariate and multivariate Cox proportional hazard models were conducted to evaluate the relationship between ECG parameters and all-cause mortality in patients with MM.ResultsA total of 409 patients were included (mean age 61.3  ± 9.7 years, 59.2% male). The relationship between ECG parameters (including PR interval, voltage, QRS axis, QRS duration, and QTc interval) and all-cause mortality in patients with MM was evaluated. Overall, patie...
Source: Advances in Therapy - April 26, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Versus Other Inhaled Corticosteroid/Long-Acting Muscarinic Antagonist/Long-Acting β 2 -Agonist (ICS/LAMA/LABA) Triple Combinations in COPD: A Systematic Literature Review and Network Meta-analysis
ConclusionThis NMA suggested that BGF MDI has comparable efficacy to other ICS/LAMA/LABA fixed-dose and open triple combination therapies in reducing exacerbations and improving lung function and symptoms in patients with moderate to very severe COPD. Further research is warranted as additional evidence regarding triple therapies, especially fixed-dose combinations, becomes available. (Source: Advances in Therapy)
Source: Advances in Therapy - April 25, 2020 Category: Drugs & Pharmacology Source Type: research

Real-World Utilisation and Bleed Rates in Patients with Haemophilia B Who Switched to Recombinant Factor IX Fusion Protein (rIX-FP): A Retrospective International Analysis
ConclusionThis retrospective review of real-world evidence demonstrated that switching to rIX-FP from prior FIX was associated with improved haemostatic efficacy and reduced factor consumption in patients with haemophilia B from Italy, Belgium and the UK. (Source: Advances in Therapy)
Source: Advances in Therapy - April 24, 2020 Category: Drugs & Pharmacology Source Type: research

The Impact of Baseline Pain Intensity on the Analgesic Efficacy of Ibuprofen/Caffeine in Patients with Acute Postoperative Dental Pain: Post Hoc Subgroup Analysis of a Randomised Controlled Trial
AbstractIntroductionA fixed dose combination (FDC) of ibuprofen 400  mg and caffeine 100 mg has been shown to be more effective than ibuprofen 400 mg alone for the treatment of acute postoperative dental pain in a phase III randomised controlled trial. A post hoc subgroup analysis of the primary data from an active-/placebo-controlled, double-blind, single-centr e, parallel-group study was conducted in patients with moderate or severe baseline pain.MethodsAfter dental surgery, patients with moderate or severe pain, which was determined on a 4-point verbal rating scale ( ‘no pain’ to ‘s...
Source: Advances in Therapy - April 24, 2020 Category: Drugs & Pharmacology Source Type: research

The Impact of Patient Support Programs on Adherence to Disease-Modifying Therapies of Patients with Relapsing-Remitting Multiple Sclerosis in Germany: A Non-Interventional, Prospective Study
This study evaluated whether PSPs have a positive impact on adherence to DMTs among patients with mild-to-moderate relapsing-remitting multiple sclerosis (RRMS) in Germany, independent of the treatment duration on DMT.MethodsThis was a non-interventional, prospective, cross-sectional, multi-center study with patient-reported outcomes. Patients reported their DMT adherence using patient adherence questionnaires at four visits during an observation period of 24  weeks; PSP participation for this period was reported at the last visit. The primary objective was to evaluate the impact of PSPs on adherence across different ...
Source: Advances in Therapy - April 24, 2020 Category: Drugs & Pharmacology Source Type: research