Disease Behaviour During the Peri-Diagnostic Period in Patients with Suspected Interstitial Lung Disease: The STARLINER Study
ConclusionsDespite home spirometry being feasible for most patients and centres, technical and analytical challenges in the home-based assessments prevented firm conclusions regarding disease behaviour. This highlights that further optimisation of the technology and analysis methods is required before widespread implementation.Trial RegistrationNCT03261037. (Source: Advances in Therapy)
Source: Advances in Therapy - June 11, 2021 Category: Drugs & Pharmacology Source Type: research

The Number of Pills, Rather Than the Type of Renin –Angiotensin System Inhibitor, Predicts Ambulatory Blood Pressure Control in Essential Hypertensives on Triple Therapy: A Real-Life Cross-Sectional Study
ConclusionThe higher prevalence of ambulatory BP control found in patients taking a triple therapy with ACEi was affected by the lower number of antihypertensive pills taken, which was also the key predictor of ambulatory BP control in our study. This confirms the importance of fixed-dose combinations in the management of essential hypertension. (Source: Advances in Therapy)
Source: Advances in Therapy - June 11, 2021 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of Ticagrelor Compared with Clopidogrel in Patients with Acute Coronary Syndrome from Vietnamese Healthcare Payers ’ Perspective
ConclusionTicagrelor can be considered a cost-effective treatment for ACS compared with clopidogrel from a Vietnamese healthcare payers' perspective. (Source: Advances in Therapy)
Source: Advances in Therapy - June 11, 2021 Category: Drugs & Pharmacology Source Type: research

Inflammatory Bowel Disease and Cannabis: A Practical Approach for Clinicians
AbstractAlthough still not approved at the federal level for medical or adult recreational use, cannabis has been approved in the United States (USA) by individual states for both of these purposes. A total of 15 states now regulate cannabis for adult use and 36 states for medical use. In more recent years, cannabis has gained popularity for the treatment of chronic conditions, inflammatory bowel disease (IBD) being one of them. However, the exact role of cannabis in the treatment of IBD remains uncertain. While cannabis may help in some instances with symptom management, it has not been proven to help with inflammation or...
Source: Advances in Therapy - June 10, 2021 Category: Drugs & Pharmacology Source Type: research

Assessment of Macular Function by Multifocal Electroretinogram in Patients with Multiple Sclerosis Treated with Fingolimod
ConclusionsOur mfERG results suggest that the chronic use of FTY does not induce a dysfunction of pre-ganglionic retinal elements located in the 0 –25° of central retina. Since FTY does not cause any retinal functional abnormality, we suggest that FTY treatment could not produce any toxic effect on pre-ganglionic retinal elements even in the absence of macular oedema. (Source: Advances in Therapy)
Source: Advances in Therapy - June 9, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic Characterization of a Prototype Mini Nicotine Lozenge
ConclusionThe prototype mini lozenge is bioequivalent to a commercially available mini lozenge and may provide smokers with a new oral NRT option to aid in smoking cessation and of tobacco dependence through the relief of nicotine withdrawal symptoms, including cravings. (Source: Advances in Therapy)
Source: Advances in Therapy - June 9, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics, Safety and Tolerability of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein (CETP) Inhibitor, After Single and Multiple Doses in Healthy Chinese Subjects
ConclusionThe PK properties of anacetrapib in Chinese subjects are comparable to those observed in the black population and in white subjects. Single and once-daily administration of anacetrapib was generally well tolerated in healthy Chinese subjects observed in this study.Trial Registrationchinadrugtrials.org.cn identifier number CTR20130983. (Source: Advances in Therapy)
Source: Advances in Therapy - June 8, 2021 Category: Drugs & Pharmacology Source Type: research

Durvalumab Plus Tremelimumab in Solid Tumors: A Systematic Review
ConclusionThe combination of durvalumab plus tremelimumab showed some oncological advantages in comparison with traditional chemotherapies in some subsets of tumors, but generally has not shown consistent advantages in comparison with the employment of durvalumab monotherapy. A number of the studies examined had intrinsic methodological limitations; therefore, future well-designed studies involving larger cohorts are warranted. (Source: Advances in Therapy)
Source: Advances in Therapy - June 8, 2021 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of Nivolumab Plus Ipilimumab Combined with Two Cycles of Chemotherapy as First-Line Treatment in Advanced Non-Small Cell Lung Cancer
ConclusionNIC was unlikely to be cost-effective as a first-line treatment for patients with advanced NSCLC. (Source: Advances in Therapy)
Source: Advances in Therapy - June 7, 2021 Category: Drugs & Pharmacology Source Type: research

Impact of Vonoprazan Triple-Drug Blister Packs on H.  pylori Eradication Rates in Japan: Interrupted Time Series Analysis
This study aimed to assess the impact of the combination blister pack on eradication success rate in Japan immediately after launch.MethodsWe performed an interrupted time series analysis using a large administrative claims database of 7,300,000 insured individuals. We identified 36,570 patients who received first-line clarithromycin triple therapy from June 2015 to May 2016 (prelaunch) and 35,721 who received the same therapy from July 2016 to June 2017 (post-launch). The primary outcome was the success rate of clarithromycin triple therapy and the secondary outcomes were proportion of vonoprazan use and proportion of com...
Source: Advances in Therapy - June 6, 2021 Category: Drugs & Pharmacology Source Type: research

Real-World Claims Analyses of Comorbidity Burden, Treatment Pattern, Healthcare Resource Utilization, and Costs in Pediatric Psoriasis
We examined patient demographics, comorbidity burden, treatment patterns, and healthcare use and costs in pediatric psoriasis.MethodsA retrospective, real-world, exploratory study was conducted using US claims databases. Pediatric patients aged  
Source: Advances in Therapy - June 6, 2021 Category: Drugs & Pharmacology Source Type: research

Cariprazine, A Broad-Spectrum Antipsychotic for the Treatment of Schizophrenia: Pharmacology, Efficacy, and Safety
AbstractSchizophrenia is characterized by positive, negative, cognitive, and affective symptoms. Antipsychotic medications, which work by blocking the dopamine  D2 receptor, are the foundation of pharmacotherapy for schizophrenia to control positive symptoms. Cariprazine is a dopamine  D3 receptor-preferring D3/D2 partial agonist antipsychotic that is approved for the treatment of schizophrenia (USA and European Union  [EU]) and manic and depressive episodes associated with bipolar I disorder (USA). Partial agonist agents have a lower intrinsic activity at receptors than full agonists, so they act as ei...
Source: Advances in Therapy - June 6, 2021 Category: Drugs & Pharmacology Source Type: research

Citicoline and Vitamin  B12 Eye Drops in Type 1 Diabetes: Results of a 36-Month Pilot Study Evaluating Macular Electrophysiological Changes
ConclusionsThis study indicates that patients with NPDR treated with citicoline and vitamin  B12 eye drops for a 36-month period achieved an improvement of the macular bioelectrical responses detectable by mfERG recordings. By contrast, during the same period of follow-up, patients with NPDR treated with placebo showed a worsening of the macular function. (Source: Advances in Therapy)
Source: Advances in Therapy - June 5, 2021 Category: Drugs & Pharmacology Source Type: research

Intraoperative Monitoring of the Obese Patient Undergoing Surgery: A Narrative Review
AbstractWith the increasing prevalence of obesity in the population, anaesthetists must confidently manage both the pathophysiological and technical challenges presented in bariatric and non-bariatric surgery. The intraoperative period represents an important opportunity to optimise and mitigate risk. However, there is little formal guidance on what intraoperative monitoring techniques should be used in this population. This narrative review collates the existing evidence for intraoperative monitoring devices in the obese patients. Although a number of non-invasive blood pressure monitors have been tested, an invasive arte...
Source: Advances in Therapy - June 5, 2021 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of Vedolizumab in the Treatment of Moderate-to-Severe Crohn ’s Disease in China
ConclusionVedolizumab appears to be a cost-effective strategy option in the treatment of adult patients with moderate-to-severe active CD in China in both anti-TNF-na ïve and anti-TNF-failure populations. (Source: Advances in Therapy)
Source: Advances in Therapy - June 5, 2021 Category: Drugs & Pharmacology Source Type: research

Platelet Reactivity and Coagulation Markers in Patients with COVID-19
AbstractIntrodutionCOVID-19 is associated with an increased risk of thrombotic events. However, the contribution of platelet reactivity (PR) to the aetiology of the increased thrombotic risk associated with COVID-19 remains unclear. Our aim was to evaluate PR in stable patients diagnosed with COVID-19 and hospitalized with respiratory symptoms (mainly dyspnoea and dry cough), in comparison with a control group comprised of non-hospitalized healthy controls.MethodsObservational, case control study that included patients with confirmed COVID-19 (COVID-19 group,n = 60) and healthy individuals matched by age and sex ...
Source: Advances in Therapy - June 4, 2021 Category: Drugs & Pharmacology Source Type: research

Management of Opioid-Induced Constipation and Bowel Dysfunction: Expert Opinion of an Italian Multidisciplinary Panel
AbstractThe prescribing and use of opioid analgesics is increasing in Italy owing to a profusion in the number and types of opioid analgesic products available, and the increasing prevalence of conditions associated with severe pain, the latter being related to population aging. Herein we provide the expert opinion of an Italian multidisciplinary panel on the management of opioid-induced constipation (OIC) and bowel dysfunction. OIC and opioid-induced bowel dysfunction are well-recognised unwanted effects of treatment with opioid analgesics that can profoundly affect quality of life. OIC can be due to additional factors su...
Source: Advances in Therapy - June 4, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Practical Approaches to Treating Obesity: Patient and Healthcare Professional Perspectives
The route of administration was published as ‘Oral’. (Source: Advances in Therapy)
Source: Advances in Therapy - June 3, 2021 Category: Drugs & Pharmacology Source Type: research

Vaccine Considerations for Multiple Sclerosis in the COVID-19 Era
The objective of this article is to provide information on immune system responses to vaccination s and review previous studies of vaccine responses in people with MS to support the safety and importance of receiving currently available and emerging COVID-19 vaccines. Immunological studies have shown that coordinated interactions between T and B lymphocytes of the adaptive immune system are key to successful generation of immunological memory and production of neutralizing antibodies following recognition of vaccine antigens by innate immune cells. CD4+ T  cells are essential to facilitate CD8+ T  cell and B...
Source: Advances in Therapy - June 1, 2021 Category: Drugs & Pharmacology Source Type: research

The Outcomes of Systemic Treatment in Recurrent Hepatocellular Carcinomas Following Liver Transplants
AbstractBackgroundTreatment of hepatocellular carcinoma (HCC) recurrences following liver transplant (LT) is challenging. Most clinical trials of systemic therapies for advanced HCC excluded patients with any history of organ transplant. We aimed to assess the outcomes in using various systemic therapies in patients with post-LT recurrence.MethodsConsecutive patients with HCC and recurrences following LT at a large tertiary centre from 2005 to 2018 were reviewed. Overall survival (OS), response rates and adverse events (AEs) were analysed.ResultsForty-three consecutive patients with a recurrence of HCC following LT were id...
Source: Advances in Therapy - June 1, 2021 Category: Drugs & Pharmacology Source Type: research

Effect of a Patient Support Program for Idiopathic Pulmonary Fibrosis Patients on Medication Persistence: A Retrospective Database Analysis
AbstractIntroductionIn 2015, Boehringer Ingelheim (BI) created a support program for patients with idiopathic pulmonary fibrosis (IPF) treated with nintedanib, to help patients obtain their prescription, learn about their disease and medication, and provide support in the management of their IPF. The purpose of this study was to measure the impact of the program on nintedanib persistence among patients with IPF newly treated with the medication.MethodsA retrospective cohort analysis of BI Pharmaceuticals, Inc. ’s Specialty Pharmacy (SP) database was conducted. Patients at least 18 years of age, newly treated with nin...
Source: Advances in Therapy - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

A Framework for Estimating the Eligible Patient Population for New Migraine Acute Therapies in the United States
ConclusionA limited number of patients currently use migraine-specific acute therapies. Among such patients, a significant proportion do not have adequate symptom control. Accordingly, a minority of individuals with migraine may be expected to use new acute therapies. The framework developed in this study is intended to facilitate estimating the eligible patient population in assessments of costs of new acute therapies. Such assessments should also consider recommendations that patients have access to multiple types of acute therapies, which may yield savings from reduced medication-overuse headache (MOH), progression to c...
Source: Advances in Therapy - May 31, 2021 Category: Drugs & Pharmacology Source Type: research

Gender Disparities in Osteoporosis Screening and Management Among Older Adults
AbstractIntroductionOne in two women and one in four men experience an osteoporosis-related fracture in their lifetime. Related morbidity and mortality rates are higher in men versus women. Current guidelines are inconsistent in the screening recommendations for osteoporosis in men. Examination of gender disparities in the management of osteoporosis-related fractures among Medicare enrollees is currently lacking.MethodsIn this retrospective cohort study using 5% National Medicare claims data from January  1, 2012 through December 31, 2016, eligible patients who were at least 65 years of age on the date of a ...
Source: Advances in Therapy - May 30, 2021 Category: Drugs & Pharmacology Source Type: research

Intravenous Iron-Induced Hypophosphatemia: An Emerging Syndrome
AbstractSome, but not all, intravenous iron formulations have been recognized to induce renal phosphate wasting syndrome. Most commonly this has been reported following treatment of iron deficiency anemia (IDA) with ferric carboxymaltose (FCM). A search of PubMed identified relevant randomized controlled trials (RCTs), and case studies evaluating hypophosphatemia (HPP) resulting from intravenous iron treatment. While more recent larger comparative RCTs have confirmed that the majority of patients receiving FCM, especially those with normal renal function, may experience severe HPP, complete documentation is hampered by inc...
Source: Advances in Therapy - May 30, 2021 Category: Drugs & Pharmacology Source Type: research

Real-World Use of Insulin Glargine U100 and U300 in Insulin-Na ïve Patients with Type 2 Diabetes Mellitus: DosInGlar Study
ConclusionIn real-world practice, insulin dose was significantly higher in IGlar U300-treated than U100-treated patients at 6, 12 and 18  months, with similar reductions in HbA1c. At equal IGlar price/unit in Spain, the increased dose requirements of IGlar U300 would result in higher costs. (Source: Advances in Therapy)
Source: Advances in Therapy - May 29, 2021 Category: Drugs & Pharmacology Source Type: research

Acetyl-l-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial
This study was designed to compare the endocrine and metabolic parameters as well as subjective and objective measures of stress in women with PCOS before and after treatment with acetyl-l-carnitine (ALC) and metformin plus pioglitazone.MethodsA total of 147 women with PCOS were randomly assigned into two groups: the combo group (n = 72) received a combination of metformin, pioglitazone, and ALC (500 mg, 15 mg, and 1500 mg, respectively), twice daily; the Met + Pio group (n = 75) received metformin plus pioglitazone (500 mg, 15 mg, respectively) and placebo...
Source: Advances in Therapy - May 28, 2021 Category: Drugs & Pharmacology Source Type: research

Melanoma In Situ: A Critical Review and Re-Evaluation of Current Excision Margin Recommendations
AbstractMost international clinical guidelines recommend 5 –10 mm clinical margins for excision of melanoma in situ (MIS). While the evidence supporting this is weak, these guidelines are generally consistent. However, as a result of the high incidence of subclinical extension of MIS, especially of the lentigo maligna (LM) subtype, wider margins will oft en be needed to achieve complete histologic clearance. In this review, we assessed all available contemporary evidence on clearance margins for MIS. No randomized trials were identified and the 31 non-randomized studies were largely retrospective reviews of sing...
Source: Advances in Therapy - May 28, 2021 Category: Drugs & Pharmacology Source Type: research

The Burden of Short-Acting β2-Agonist Use in Asthma: Is There an Italian Case? An Update from SABINA Program
ConclusionSABA overuse is common in Italy, with a share of consumption not regulated by medical prescriptions. Because SABA overuse increases exacerbation risk, changes to national guidelines should be encouraged to ensure implementation of global recommendations. (Source: Advances in Therapy)
Source: Advances in Therapy - May 27, 2021 Category: Drugs & Pharmacology Source Type: research

Multiple Docetaxel Retreatments Without Prednisone for Metastatic Castration-Resistant Prostate Cancer in the Docetaxel-Only Era: Effects on PSA Kinetics and Survival
This study aimed to assess the effects of multiple docetaxel (DOC) treatments on prostate-specific antigen (PSA) kinetics and survival among patients with metastatic castration-resistant prostate cancer (mCRPC) who were sensitive to first-line DOC and received no other life-prolonging agents. To eliminate the effect of cortisone on serum PSA, only patients who were treated without prednisone were included.MethodsThis IRB-approved retrospective study evaluated 52 patients with mCRPC who were retreated using DOC after first-line DOC (without prednisone in both cases), based on a PSA response of  >  50% and n...
Source: Advances in Therapy - May 27, 2021 Category: Drugs & Pharmacology Source Type: research

Phase III Clinical Trials in First-Line Follicular Lymphoma: A Review of Their Design and Interpretation
AbstractFollicular lymphoma (FL) is one of the most common subtypes of non-Hodgkin lymphoma worldwide. Improved survival outcomes with rituximab-based therapy in clinical trials led to the establishment of rituximab-based immunochemotherapy as standard of care for first-line (1L) treatment of FL. In the GALLIUM trial, obinutuzumab-based immunochemotherapy demonstrated improved progression-free survival (PFS), prolonged time-to-next antilymphoma treatment (TTNT) and comparable overall survival (OS) compared with rituximab-based immunochemotherapy as 1L treatment for FL. Using GALLIUM as an example, this article aims to expl...
Source: Advances in Therapy - May 26, 2021 Category: Drugs & Pharmacology Source Type: research

Predictors and Correlative Factors for Low Back Pain after Long Fusion Arthrodesis in Patients with Adult Scoliosis
AbstractIntroductionLow back pain (LBP) still exists at the follow-up visit in some cases after long fusion arthrodesis for adult scoliosis. However, few available studies have elaborated the reasons and factors associated with this symptom. Therefore, the aim of the current study was to identify the correlative factors and predictors of postoperative LBP after long fusion arthrodesis and provide evidence to improve the surgical strategy.MethodsSeventy-nine patients with adult scoliosis who underwent long fusion arthrodesis were divided into a group with no or mild LBP (NLBP group) and one with moderate or severe LBP (MLBP...
Source: Advances in Therapy - May 26, 2021 Category: Drugs & Pharmacology Source Type: research

Systemic ALCL Treated in Routine Clinical Practice: Outcomes Following First-Line Chemotherapy from a Multicentre Cohort
ConclusionThese data serve as a robust benchmark for BV-CHP as the new standard of care for sALCL. Similar real-world evidence with BV-CHP will be desirable to confirm the findings of ECHELON-2. (Source: Advances in Therapy)
Source: Advances in Therapy - May 26, 2021 Category: Drugs & Pharmacology Source Type: research

Comparative Effectiveness and Safety of Rivaroxaban and Warfarin Among Nonvalvular Atrial Fibrillation (NVAF) Patients with Obesity and Polypharmacy in the United States (US)
ConclusionsThese results suggest that rivaroxaban is an effective and safe treatment option among NVAF patients with obesity and polypharmacy in a commercially-insured US population. (Source: Advances in Therapy)
Source: Advances in Therapy - May 25, 2021 Category: Drugs & Pharmacology Source Type: research

The Additive Effect of ROCK Inhibitor on Prostaglandin-Treated Japanese Patients with Glaucoma Indicating 15  mmHg and Under: ROCK U-15
AbstractIntroductionWe aimed to evaluate the additional effects and safety of a Rho-associated protein kinase (ROCK) inhibitor, ripasudil hydrochloride hydrate, in Japanese patients with primary open-angle glaucoma (POAG) with an intraocular pressure (IOP) of at most 15  mmHg undergoing prostaglandin F2 α (FP) receptor agonist monotherapy (FP  monotherapy).MethodsIn this prospective observational study, 30 Japanese patients with POAG and IOP of at most 15  mmHg (mean age 59.4 years; 10 men) who were undergoing FP monotherapy in both eyes were administered an additional dose of ripasudil ...
Source: Advances in Therapy - May 24, 2021 Category: Drugs & Pharmacology Source Type: research

Modeling the Cost Savings of Continuous Pulse Oximetry and Capnography Monitoring of United States General Care Floor Patients Receiving Opioids Based on the PRODIGY Trial
ConclusionCompared to intermittent pulse oximetry, continuous pulse oximetry and capnography monitoring of general care floor patients receiving opioids has a high chance of being cost-effective.Trial Registrationwww.clinicaltrials.gov, Registration ID: NCT02811302. (Source: Advances in Therapy)
Source: Advances in Therapy - May 24, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Capsule and Sprinkle Formulations of Lubiprostone Are Not Biologically Similar in Patients with Functional Constipation
A correction to this paper has been published: https://doi.org/10.1007/s12325-021-01776-w (Source: Advances in Therapy)
Source: Advances in Therapy - May 24, 2021 Category: Drugs & Pharmacology Source Type: research

Serratus Anterior Plane Block Combined with General Analgesia and Patient-Controlled Serratus Anterior Plane Block in Patients with Breast Cancer: A Randomized Control Trial
This study aimed to observe the early effectiveness and safety of serratus anterior plane block combined with general anesthesia and patient-controlled serratus anterior plane block in early postoperative r ecovery in breast cancer.MethodsThe study involved a total of 84 patients undergoing radical mastectomy in our hospital. The patients were randomly divided into three groups: the serratus anterior block  + general anesthesia + patient-controlled serratus anterior plane block group (PCSAPB group), the serratus anterior block + general anesthesia + patient-controlled...
Source: Advances in Therapy - May 22, 2021 Category: Drugs & Pharmacology Source Type: research

Safety of Patients with Hepatitis  C Virus Treated with Glecaprevir/Pibrentasvir from Clinical Trials and Real-World Cohorts
ConclusionThe safety profile of glecaprevir/pibrentasvir enhances the confidence of non-liver specialists to treat the majority of HCV-infected patients, and provides an opportunity to expand the treater pool, potentially increasing diagnosis and treatment rates for HCV, contributing to elimination of HCV. (Source: Advances in Therapy)
Source: Advances in Therapy - May 22, 2021 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of Tisagenlecleucel in Paediatric Acute Lymphoblastic Leukaemia (pALL) and Adult Diffuse Large B-Cell Lymphoma (DLBCL) in Switzerland
ConclusionUsing hypothetical willingness-to-pay thresholds of CHF 100,000 –150,000 per QALY gained, the present analysis has shown tisagenlecleucel to be a cost-effective treatment option in pALL and DLBCL. (Source: Advances in Therapy)
Source: Advances in Therapy - May 22, 2021 Category: Drugs & Pharmacology Source Type: research

Comparison of PD-L1 Scores in Primary Kidney Tumors Versus Accompanying Venous Tumor Thrombi: Retrospective, Comparative, Monocentric Study in Treatment-Naive Patients
ConclusionTo the best of our knowledge, this research is the largest study to investigate PD-L1 expression in PTs and VTT in 71 cases. It could have relevance for the future development of neoadjuvant immunotherapy options, particularly in aRCC with VTT. (Source: Advances in Therapy)
Source: Advances in Therapy - May 21, 2021 Category: Drugs & Pharmacology Source Type: research

Unmet Clinical Needs in Elderly Patients Receiving Direct Oral Anticoagulants for Stroke Prevention in Non-valvular Atrial Fibrillation
AbstractVitamin K antagonists have been used for many years as the treatment of choice for long-term oral anticoagulation in patients with non-valvular atrial fibrillation. Unfortunately, the use of those drugs in the real-world setting, particularly among elderly patients, is suboptimal because of their limitations in management. Therefore, many patients were not adequately anticoagulated. Direct oral anticoagulants have been demonstrated to overcome almost all the limitations derived from the use of vitamin K antagonists. Direct oral anticoagulants are at least as effective as vitamin K antagonists in preventing thromboe...
Source: Advances in Therapy - May 21, 2021 Category: Drugs & Pharmacology Source Type: research

Clinical Features of Ocular Pathology in Patients with Acquired Immunodeficiency Syndrome and Syphilis
ConclusionThe incidence of ocular pathology was high in patients co-infected with AIDS and syphilis, which might manifest in a variety of ocular manifestations; some patients may also have multiple ocular changes, which should be given great clinical attention. (Source: Advances in Therapy)
Source: Advances in Therapy - May 21, 2021 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of Atezolizumab Plus Chemotherapy as First-Line Therapy for Metastatic Urothelial Cancer
ConclusionsFrom the US payer perspective, atezolizumab plus platinum-based chemotherapy is not cost-effective in the first-line therapy for patients with mUC on the basis of a WTP threshold of $150,000 per QALY. On the basis of the value standpoint, price reduction of atezolizumab is expected to improve the cost-effectiveness of atezolizumab in patients with mUC. (Source: Advances in Therapy)
Source: Advances in Therapy - May 21, 2021 Category: Drugs & Pharmacology Source Type: research

Effects of Combined Lipid-Lowering Therapy on Low-Density Lipoprotein Cholesterol Variability and Cardiovascular Adverse Events in Patients with Acute Coronary Syndrome
AbstractIntroductionTo investigate the effect of combined lipid-lowering therapy on low-density lipoprotein cholesterol (LDL-C) variability and cardiovascular adverse events in patients with acute coronary syndrome (ACS).MethodsA total of 200 patients with acute coronary syndrome, admitted to the first Hospital of Hebei Medical University from January 2018 to June 2019, were randomly divided into the observation group (100 cases were treated with combined lipid-lowering drugs, including 10  mg/day atorvastatin and 10 mg/day ezetimibe) and the control group (100 cases were given an intensive statin regimen, includ...
Source: Advances in Therapy - May 21, 2021 Category: Drugs & Pharmacology Source Type: research

The Long-Term Impact of Levodopa/Carbidopa Intestinal Gel on ‘Off’-time in Patients with Advanced Parkinson’s Disease: A Systematic Review
ConclusionIn one of the largest qualitative syntheses of published LCIG studies, LCIG treatment was observed to provide a durable effect in reducing ‘off’-time.InfographicVideo Abstract (Source: Advances in Therapy)
Source: Advances in Therapy - May 20, 2021 Category: Drugs & Pharmacology Source Type: research

Natalizumab in Early Relapsing-Remitting Multiple Sclerosis: A 4-Year, Open-Label Study
ConclusionThese results support the long-term safety and effectiveness of natalizumab. Baseline predictors of NEDA help to inform benefit-risk assessments of natalizumab treatment in JCV-negative patients with early RRMS.Trial RegistrationClinicalTrials.gov identifier NCT01485003. (Source: Advances in Therapy)
Source: Advances in Therapy - May 20, 2021 Category: Drugs & Pharmacology Source Type: research

Overexpression of NOP58 as a Prognostic Marker in Hepatocellular Carcinoma: A TCGA Data-Based Analysis
AbstractIntroductionNOP58 ribonucleoprotein, a core component of box C/D small nucleolar ribonucleoproteins, is involved in various cell physiological processes. However, its role in hepatocellular carcinoma (HCC) remains very unclear. We aim to investigateNOP58 expression and its probable prognostic value in patients with HCC based on The Cancer Genome Atlas (TCGA) database.MethodsRNA sequencing data and clinicopathological characteristics of patients with HCC were collected from TCGA database. Expression ofNOP58 in HCC tissues and normal tissues was analyzed by Wilcoxon rank-sum test. Patients were divided into high and ...
Source: Advances in Therapy - May 20, 2021 Category: Drugs & Pharmacology Source Type: research

Economic Burden and Impact on Quality of Life of Herpes Zoster in Spanish Adults Aged 50  Years or Older: A Prospective Cohort Study
ConclusionsIn Spain, HZ and HZ-related complications such as PHN reduce patient HRQL and increase the economic burden for both payers and society in general.Trail RegistrationClinicalTrials.gov identifier NCT01521286. (Source: Advances in Therapy)
Source: Advances in Therapy - May 19, 2021 Category: Drugs & Pharmacology Source Type: research

Frequency of Diabetic Ketoacidosis in Patients with Type  1 Diabetes Using FreeStyle Libre: A Retrospective Chart Review
AbstractIntroductionDiabetic ketoacidosis (DKA) is an acute complication associated with poorly managed or undiagnosed diabetes. DKA is associated with significant morbidity, mortality, and healthcare costs, but can be prevented with appropriate management of diabetes. The FreeStyle Libre is flash glucose monitoring device that measures glucose levels in the interstitial subcutaneous tissue and has been shown to reduce HbA1c, time in hypoglycemia and hyperglycemia, as well as improve health-related quality of life.MethodsA retrospective chart review of patients with type  1 diabetes mellitus (T1DM) and recurrent DKA a...
Source: Advances in Therapy - May 19, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Real-World Trends in Characteristics of Patients with Migraine Newly Initiated on Erenumab in the USA: A Retrospective Analysis
A correction to this paper has been published: https://doi.org/10.1007/s12325-021-01744-4 (Source: Advances in Therapy)
Source: Advances in Therapy - May 18, 2021 Category: Drugs & Pharmacology Source Type: research