Correction to: Liaoning Score for Prediction of Esophageal Varices in Cirrhotic Patients Who Had Never Undergone Endoscopy: A Multicenter Cross-Sectional Study in Liaoning Province, China
Unfortunately, the fourteenth author ’s name was incorrectly published in the Original Article. The correct author name is Cen Hong. (Source: Advances in Therapy)
Source: Advances in Therapy - June 24, 2019 Category: Drugs & Pharmacology Source Type: research

Economic and Clinical Burden of Relapsed and/or Refractory Active Treatment Episodes in Patients with Acute Myeloid Leukemia (AML) in the USA: A Retrospective Analysis of a Commercial Payer Database
AbstractThis retrospective study estimated healthcare resource use (HRU), symptoms and toxicities (SxTox), and costs in relapsed/refractory (R/R) patients with acute myeloid leukemia (AML), stratified by hematopoietic stem cell transplantation (HSCT) status. Claims data were used to identify adult patients with AML diagnoses from 1 January 2008 to 31 March 2016 in the USA. Patients were considered R/R if they had an AML relapse ICD-9 code (205.02) or a line of therapy consistent with R/R disease. The final R/R sample (N = 707) included 476 patients with and 231 patients without HSCT. The mean total episode co...
Source: Advances in Therapy - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

Factors Associated with Improvements in Patient-Reported Outcomes During Mirabegron or Antimuscarinic Treatment of Overactive Bladder Syndrome: A Registry Study (PERSPECTIVE)
ConclusionThere are no differences between mirabegron and antimuscarinics in terms of patient-reported OAB symptom bother and HRQoL.Trial RegistrationClinicalTrials.gov identifier, NCT02386072.FundingAstellas Pharma Global Development, Inc.Plain Language SummaryPlain language summary available for this article. (Source: Advances in Therapy)
Source: Advances in Therapy - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

Meta-Analysis of Regorafenib-Associated Adverse Events and Their Management in Colorectal and Gastrointestinal Stromal Cancers
ConclusionRegorafenib-associated AEs are more common at an initiating dose of 160  mg. Considering that the efficacy depends on the dosage, 120 mg might be a better choice for mCRC and GIST patients; further studies are needed to validate the results of our analysis. Further prompt identification and management of AEs are required to help the patients continue with drug therapy . (Source: Advances in Therapy)
Source: Advances in Therapy - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Clinical and Psychological Outcomes of the Use of Vaginal Dilators After Gynaecological Brachytherapy: a Randomized Clinical Trial
ConclusionThe use of VD did not alter the dimensions of the vaginal canal within the first 3  months after the end of radiotherapy treatment. However, there was a large sample loss during follow-up so studies with a larger sample number and longer follow-up time need to be conducted.Trial RegistrationClinicalTrials.gov Identifier NCT03090217. (Source: Advances in Therapy)
Source: Advances in Therapy - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Immune Checkpoint Inhibitors in Small Cell Lung Cancer: A Partially Realized Potential
AbstractSmall cell lung cancer (SCLC) is a highly lethal subtype of lung cancer that has seen few therapeutic advances, despite ongoing concerted efforts. Immunotherapy has been an effective option in other carcinogen-related cancers and has shown modest activity in SCLC. Monotherapy with the anti-PD-1 antibody nivolumab in patients with at least two prior lines of therapy was associated with a response rate of 11.9% and a median duration of response of 17.9  months, leading to accelerated approval by the Food and Drug Administration (FDA) as third-line therapy for SCLC. Second-line checkpoint inhibitors have not perf...
Source: Advances in Therapy - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Sleep Quality and Congestion with Breathe Right Nasal Strips: Two Randomized Controlled Trials
ConclusionsBRNS did not significantly improve subjective measures of sleep quality and nasal congestion compared with placebo strips in this population of chronic nocturnal congestion sufferers with self-reported sleep impairment, possibly due to a strong placebo effect.FundingGlaxoSmithKline Consumer Healthcare.ClinicalTrials.gov Registration NumbersStudy 1: NCT03549117; Study 2: NCT03549130. (Source: Advances in Therapy)
Source: Advances in Therapy - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours
ConclusionsA correct histopathological diagnosis of these tumours is necessary due to (1) preventing confusion with malignant salivary gland tumours; (2) only one (pleomorphic adenoma) has a considerable risk for malignant transformation, but all four histological types of  basal cell adenoma can occasionally develop into malignancy, as does Warthin tumour; (3) sialadenoma papilliferum, oncocytoma, canalicular adenoma, myoepithelioma and Warthin tumour only occasionally recur; while (4) intraductal and inverted papilloma, lymphadenoma, sebaceous adenoma, cystadenoma , basal cell adenoma (apart from the membranous...
Source: Advances in Therapy - June 17, 2019 Category: Drugs & Pharmacology Source Type: research

Development of a Patient-Reported Outcome Measure for Chronic Hypoparathyroidism
ConclusionThe Hypoparathyroidism Symptom Diary was developed following the recommendations of the FDA ’s PRO guidance. The measure addresses a comprehensive set of symptoms, as well as key impacts of hypoparathyroidism deemed important by patients.FundingShire Human Genetic Therapies, Inc., Lexington, MA, USA, a member of the Takeda group of companies. (Source: Advances in Therapy)
Source: Advances in Therapy - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

A Review of the Totality of Evidence Supporting the Development of the First Adalimumab Biosimilar ABP 501
AbstractABP 501 [United States: AMJEVITA ™ (adalimumab-atto); European Union: AMGEVITA® (adalimumab)] is the first approved biosimilar to adalimumab [reference product (RP)], a monoclonal antibody (mAb) targeting tumor necrosis factor-alfa (TNF- α). ABP 501 has received approval for use in indications that adalimumab RP is approved for, except those protected by regulatory exclusivity. A systematic step-wise totality of evidence (TOE) approach formed the basis of approval of ABP 501; this involved methodical accumulation of scientifically robust comparative data supporting similarity in analytical, preclini...
Source: Advances in Therapy - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Treatment of Hypertensive and Hypercholesterolaemic Patients with the Triple Fixed Combination of Atorvastatin, Perindopril and Amlodipine: The Results of the CORAL Study
AbstractIntroductionHypertension and hypercholesterolaemia are important contributors to the development and progression of atherosclerosis. The coexistence of these two conditions is rather common: hypercholesterolaemia is present in 40 –60% of hypertensive patients. Remarkably, patient compliance with antihypertensive regimens is better than with statin therapy. Thus, the inclusion of statins and blood pressure-lowering agents into a fixed combination might even double the effectiveness of statin therapy, and thereby achieve sig nificantly greater reduction of cardiovascular risk. The CORAL study was a 3-month, pro...
Source: Advances in Therapy - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Correction to: A Multicenter, Observational, Prospective Study of the Effectiveness of Switching from Budesonide/Formoterol Turbuhaler ® to Budesonide/Formoterol Easyhaler ®
Unfortunately, the mean difference in change from baseline ACT was incorrectly reported in the abstract as 19.0 vs. 20.8 instead of18.9 vs. 20.7 (Source: Advances in Therapy)
Source: Advances in Therapy - June 9, 2019 Category: Drugs & Pharmacology Source Type: research

The Management of Type 2 Diabetes with Once-Weekly Semaglutide Versus Dulaglutide: A Long-Term Cost-Effectiveness Analysis in Slovakia
ConclusionBoth doses of once-weekly semaglutide represent cost-saving treatment options versus dulaglutide 1.5  mg for obese patients with type 2 diabetes in Slovakia.FundingNovo Nordisk A/S. (Source: Advances in Therapy)
Source: Advances in Therapy - June 5, 2019 Category: Drugs & Pharmacology Source Type: research

Economic Impact of Non-Medical Switching from Originator Biologics to Biosimilars: A Systematic Literature Review
ConclusionReal-world studies reporting the economic impact of biosimilar NMS separately from drug costs are emerging, and those that reported such results found increased HRU in patients with biosimilar NMS. Studies of cost estimation have been largely limited to drug prices. Comprehensive evaluation of the economic impact of NMS should incorporate all important elements of healthcare service needs such as drug price, biologic rebates, HRU, NMS program setup, administration and monitoring costs.FundingAbbVie. (Source: Advances in Therapy)
Source: Advances in Therapy - June 5, 2019 Category: Drugs & Pharmacology Source Type: research

Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases
AbstractInosine pranobex (IP), commonly known as inosine acedoben dimepranol, isoprinosine and methisoprinol, has been proven to positively impact the host ’s immune system, by enhancing T-cell lymphocyte proliferation and activity of natural killer cells, increasing levels of pro-inflammatory cytokines, and thereby restoring deficient responses in immunosuppressed patients. At the same time, it has been shown that it can affect viral RNA levels and hence inhibit growth of several viruses. Due to its immunomodulatory and antiviral properties, and its safety profile, it has been widely used since 1971 against viral in...
Source: Advances in Therapy - June 5, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of Online Prescription Management Systems on Biologic Treatment Initiation
This study evaluated the impact of the HUMIRA Complete Pro (HCPro) online prescription management system on the rate of abandonment and the time to first fill for patients prescribed adalimumab (ADA). A retrospective cohort analysis of patients initiating ADA treatment with or without use of the HCPro online prescription processing system was used to evaluate the impact of HCPro on treatment initiation outcomes.MethodsPatient-level data for patients with an ADA prescription processed through HCPro were mapped to Symphony Health claims for patients initiating ADA between January 2012 and January 2015. The sample included pa...
Source: Advances in Therapy - June 5, 2019 Category: Drugs & Pharmacology Source Type: research

Reducing Cost and Complexity of Fecal Microbiota Transplantation Using Universal Donors for Recurrent Clostridium difficile Infection
AbstractIntroductionFecal microbiota transplantation resolves recurrentClostridium difficile infections in greater than 82% of patients. Highly screened, processed universal donor fecal material is available. We compared cost and scheduling efficiency of fecal microbiota transplantation by universal donors to patient-directed donors.MethodsMedical records from a prospectively maintained database of recurrentC.  difficile patients who underwent fecal microbiota transplantation between 2012 and 2017 were reviewed retrospectively. Patient-directed donor stool was prepared in our microbiology laboratory using protocol-bas...
Source: Advances in Therapy - June 1, 2019 Category: Drugs & Pharmacology Source Type: research

Aspirin Versus Clopidogrel Monotherapy for the Treatment of Patients with Stable Coronary Artery Disease: A Systematic Review and Meta-Analysis
ConclusionThis analysis did not show any significant difference in all-cause mortality, cardiac death, myocardial infarction, stroke, and BARC grade 3 or above among CAD patients who were treated with either ASA or clopidogrel monotherapy. However, as a result of the limited data, this hypothesis should be confirmed in other major trials. (Source: Advances in Therapy)
Source: Advances in Therapy - June 1, 2019 Category: Drugs & Pharmacology Source Type: research

Letter: An Economic Evaluation of Iron Isomaltoside 1000 Versus Ferric Carboxymaltose in Patients with Inflammatory Bowel Disease and Iron Deficiency Anemia in Denmark
(Source: Advances in Therapy)
Source: Advances in Therapy - June 1, 2019 Category: Drugs & Pharmacology Source Type: research

Correction to: Immunogenic Yeast-Based Fermentation Product Reduces Allergic Rhinitis-Induced Nasal Congestion: A Randomized, Double-Blind, Placebo-Controlled Trial
The article ‘‘Immunogenic Yeast-Based Fermentation Product Reduces Allergic Rhinitis-Induced Nasal Congestion: A Randomized, Double-Blind, Placebo-Controlled Trial’’, written by Mark A. Moyad, Larry E. Robinson, Julie M. Kittelsrud, Stuart G. Reeves, Susan E. Weaver, Aireen I. Guzman, Mark E. Bubak was originally published electronically on the publisher’s internet portal (currently Springer-Link) on 12 August, 2009. (Source: Advances in Therapy)
Source: Advances in Therapy - June 1, 2019 Category: Drugs & Pharmacology Source Type: research

Two-Year Outcomes After Aquablation Compared to TURP: Efficacy and Ejaculatory Improvements Sustained
ConclusionTwo-year efficacy outcomes after TURP and Aquablation were similar, and the rate of surgical retreatment was low and similar to TURP.Trial RegistrationClinicalTrials.gov no. NCT02505919.FundingPROCEPT BioRobotics. (Source: Advances in Therapy)
Source: Advances in Therapy - May 23, 2019 Category: Drugs & Pharmacology Source Type: research

Response to “A Rigorous Evaluation of Methoxyflurane is Needed: Comment on ‘Methoxyflurane Versus Standard of Care for Acute Trauma-Related Pain in the Emergency Setting: Protocol for a Randomised, Controlled Study in Italy (MEDITA)’”
(Source: Advances in Therapy)
Source: Advances in Therapy - May 23, 2019 Category: Drugs & Pharmacology Source Type: research

Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study
ConclusionsEsaxerenone has a high absolute bioavailability of approximately 90% and food has no effect on esaxerenone PK after a single oral dose of 5  mg in healthy Japanese subjects. Additionally, no safety concerns were identified.Clinical Trial RegistrationJapicCTI No. 163452.FundingDaiichi Sankyo Co., Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Second-Generation Trabecular Micro-Bypass Stents as Standalone Treatment for Glaucoma: A 36-Month Prospective Study
AbstractIntroductionTo evaluate long-term outcomes following stand-alone implantation of two second-generation trabecular micro-bypass stents (iStentinject®, Glaukos Corp., San Clemente, CA, USA) in eyes with predominantly primary open-angle glaucoma (POAG) and considerable preoperative disease burden.MethodsEyes with POAG, pseudoexfoliative glaucoma (PXG), appositional narrow-angle glaucoma (NAG, with open-angle configuration in the area of implantation), or secondary glaucoma were included in this prospective, non-randomized, consecutive case series. All eyes underwentab interno iStentinject implantation as a sole pr...
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

YINGLONG: A Multicenter, Prospective, Non-Interventional Study Evaluating the Safety and Tolerability of Ticagrelor in Chinese Patients with Acute Coronary Syndrome
ConclusionsTicagrelor was well tolerated with a low rate of PLATO-defined major bleeding events in Chinese ACS patients. Safety results were consistent with the known ticagrelor profile.Trial RegistrationClinicalTrials.gov identifier, NCT02430493.FundingAstraZeneca Investment (China) Co., Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic Drug Interactions Between Amlodipine, Valsartan, and Rosuvastatin in Healthy Volunteers
ConclusionWhen amlodipine, valsartan, and rosuvastatin were coadministered to healthy volunteers, the pharmacokinetic exposure to valsartan was decreased, but no change in exposure to amlodipine and rosuvastatin occurred. All treatments were well tolerated.Clinical Trial Registrationhttps://cris.nih.go.kr CRIS KCT0001660.FundingKyungDong Pharmaceutical Corp. Ltd., Seoul, Republic of Korea. (Source: Advances in Therapy)
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Management of Fibrosing Interstitial Lung Diseases
AbstractA proportion of patients with interstitial lung diseases (ILDs), including the ILDs that are commonly associated with autoimmune diseases, develop a progressive fibrosing phenotype characterised by worsening of lung function, dyspnoea and quality of life, and early mortality. No drugs are approved for the treatment of ILDs other than idiopathic pulmonary fibrosis (IPF). At present, immunomodulatory medications are the mainstay of treatment for non-IPF ILDs. However, with the exception of systemic sclerosis-associated ILD, the evidence to suggest that immunosuppression may preserve lung function in patients with the...
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Objective and Subjective Effects of a Prototype Nasal Dilator Strip on Sleep in Subjects with Chronic Nocturnal Nasal Congestion
AbstractIntroductionThis exploratory study characterized the performance of a nasal dilator strip with improved spring forces in lowering nasal resistance during sleep and reducing sleep-disordered breathing in subjects with difficulty sleeping due to chronic nocturnal nasal congestion.MethodsSubjects applied the strip at bedtime for 28  days (active phase;n = 70). Objective assessments included snoring variables, breathing route during sleep, and polysomnography measures compared with baseline. Nasal breathing, congestion, and sleep were measured subjectively using rating scales and questionnaires. Duri...
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Some Considerations on the WHO Histological Classification of Laryngeal Neoplasms
AbstractA new edition of the World Health Organization (WHO) Histological classification of tumours of the hypopharynx, larynx, trachea and parapharyngeal space was published in 2017. We have considered this classification regarding laryngeal neoplasms and discuss the grounds for said revision. Many of the laryngeal neoplasms described in the literature and in the previous WHO edition from 2005 have been omitted from this current revision. Many are described elsewhere in the book but it may give the new generation of pathologists/surgeons/oncologists the false impression that these tumour entities do not exist in the laryn...
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Characteristics of Patients with Type-1 or Type-2 Diabetes Receiving Insulin Glargine U300: An Analysis of 7268 Patients Based on the DPV and DIVE Registries
ConclusionThe data confirm the clinical profile documented for U300 in the EDITION studies during the first years of its registration. In an unselected patient population, there was a lesser rate of severe hypoglycemia but at a comparable HbA1c.FundingGerman Centre for Diabetes Research (DZD) (01GI1106), the European Foundation for the Study of Diabetes (EFSD) and the German Diabetes Society (DDG). The DIVE registry (organized as Diabetes Agenda 2010 GmbH, Berlin, Germany) received funding from Sanofi, AstraZeneca, Bayer, and Abbott and was conducted under the auspices of diabetesDE. (Source: Advances in Therapy)
Source: Advances in Therapy - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Drug Survival of Biological Therapies for Psoriasis Treatment in Germany and Associated Costs: A Retrospective Claims Database Analysis
ConclusionObserved drug survival rates in this real-world setting were relatively low. In line with previous studies, ustekinumab had a higher persistence rate than other biologics.FundingJanssen-Cilag. (Source: Advances in Therapy)
Source: Advances in Therapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Risk of Developing Additional Immune-Mediated Manifestations: A Retrospective Matched Cohort Study
ConclusionsThis study demonstrates that the risk of developing a second IMID is significantly higher for individuals who have already experienced a first IMID in a large and contemporary US claims database. Certain pairs of IMIDs co-occur more frequently than others. The risk of developing subsequent IMIDs may be an important consideration for clinicians when selecting treatment strategies.FundingAbbvie. (Source: Advances in Therapy)
Source: Advances in Therapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia
ConclusionsLomitapide demonstrated promising effectiveness in paediatric HoFH patients. Adverse events were manageable, and the clinical profile of the drug is apparently similar to that in adult patients.FundingAmryt Pharma. (Source: Advances in Therapy)
Source: Advances in Therapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

How Successful is Switching from Bevacizumab or Ranibizumab to Aflibercept in Age-Related Macular Degeneration? A Systematic Overview
AbstractEmerging anti-vascular endothelial growth factor (anti-VEGF) therapies for neovascular age-related macular degeneration (nAMD) have revolutionised medical retina practice and the management and eventual outcome of nAMD. Recent research has focused on evaluating and comparing the efficacy of the two most widely employed anti-VEGF agents, bevacizumab and ranibizumab; however, a subgroup of patients with nAMD demonstrates a suboptimal response to standard therapy. We have therefore conducted a review of pertinent studies published until August 2018 which have documented the clinical efficacy when switching to a differ...
Source: Advances in Therapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Extended Stability of Reconstituted and Diluted SB3 (Trastuzumab Biosimilar) Assessed by Physicochemical and Biological Properties
ConclusionThe physicochemical stability and biological activity of reconstituted and diluted SB3 are maintained for extended time periods beyond those denoted in the product labeling, which allows for advanced SB3 preparation and may reduce drug wastage and preparation time.FundingSamsung Bioepis Co., Ltd. (Source: Advances in Therapy)
Source: Advances in Therapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Improving the Timely Detection of Bladder and Kidney Cancer in Primary Care
AbstractBladder and kidney cancer are the 10th and 7th most common cancers in the United  Kingdom (UK). They present with symptoms that are typically investigated via the same diagnostic pathway. However, diagnosing these cancers can be challenging, especially for kidney cancer, as many of the symptoms are non-specific and occur commonly in patients without cancer. Furthermore, the rec ognition and evaluation of these symptoms may differ because of the lack of supporting high-quality evidence to inform management, a problem also reflected in currently ambiguous guidelines. The majority of these two cancers are diagnos...
Source: Advances in Therapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Meropenem –Vaborbactam Versus Best Available Therapy for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Patients Without Prior Antimicrobial Failure: A Post Hoc Analysis
ConclusionMV was superior to BAT in the subgroup of patients with serious carbapenem-resistant Enterobacteriaceae (CRE) infections and no prior antimicrobial failure, with very high rates of clinical success, and was well tolerated. Post approval and real-world studies remain essential to clearly define the most appropriate population for early, empirical MV coverage, in accordance with antimicrobial stewardship principles.FundingThe Medicines Company. (Source: Advances in Therapy)
Source: Advances in Therapy - May 16, 2019 Category: Drugs & Pharmacology Source Type: research

Liaoning Score for Prediction of Esophageal Varices in Cirrhotic Patients Who Had Never Undergone Endoscopy: A Multicenter Cross-Sectional Study in Liaoning Province, China
AbstractBackground and AimsEndoscopy is necessary for assessment of esophageal varices (EVs) in cirrhotic patients, but its use is limited because of the poor compliance of patients and shortage of public health resources at primary hospitals or rural areas, especially in less well developed countries. A multicenter cross-sectional study aimed to establish a novel non-invasive score for prediction of EVs in cirrhotic patients who had never undergone endoscopy.MethodsPatients with liver cirrhosis regardless of acute upper gastrointestinal bleeding (AUGIB) who underwent the first-time upper gastrointestinal endoscopy at 11 h...
Source: Advances in Therapy - May 15, 2019 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness of the Use of Autologous Cell Harvesting Device Compared to Standard of Care for Treatment of Severe Burns in the United States
This study utilizes a health economic modeling approach to estimate cost-effectiveness and burn center budget-impact for the use of the RECELL® Autologous Cell Harvesting Device to prepare autologous skin cell suspension (ASCS) compared to standard of care (SOC) split-thickness skin graft (STSG) for the treatment of severe burn injuries requiring surgical intervention for definitive closure.MethodsA hospital-perspective model using sequential decision trees depicts the acute burn care pathway (wound assessment, debridement/excision, temporary coverage, definitive closure) and predicts the relative differences between u...
Source: Advances in Therapy - May 7, 2019 Category: Drugs & Pharmacology Source Type: research

Relative Oral Bioavailability of an Abuse-Deterrent, Immediate-Release Formulation of Oxycodone, Oxycodone ARIR in a Randomized Study
ConclusionIn this single-dose pharmacokinetic evaluation, fasted Oxycodone ARIR 30  mg had similar bioavailability to and is expected to have the same efficacy and safety profile as IR oxycodone. When administered in the fed state, pharmacokinetic parameters were slightly higher; however, these differences were considered not clinically meaningful and show that Oxycodone ARIR can be administered with or without food.FundingThis study was funded by Inspirion Delivery Sciences, LLC. Daiichi Sankyo, Inc. funded the journal ’s article processing charges and open access fee.Plain Language SummaryPlain language summar...
Source: Advances in Therapy - May 7, 2019 Category: Drugs & Pharmacology Source Type: research

A Structured Literature Review of the Epidemiology and Disease Burden of Non-Alcoholic Steatohepatitis (NASH)
ConclusionThis first broad-ranging examination of NASH literature revealed a paucity of evidence, with poor-quality, small studies found. The overwhelming impact of NASH and its patient and healthcare burden is evident. Further evidence is needed to improve our understanding of NASH, especially as fibrosis stages advance.FundingGilead Science Inc. (Source: Advances in Therapy)
Source: Advances in Therapy - May 7, 2019 Category: Drugs & Pharmacology Source Type: research

Advances in Clinical Cardiology 2018: A Summary of Key Clinical Trials
ConclusionThis article presents key clinical trials completed during 2018 and should be valuable to both cardiology clinicians and researchers. (Source: Advances in Therapy)
Source: Advances in Therapy - May 7, 2019 Category: Drugs & Pharmacology Source Type: research

Different Solutions for Damaged Nasotracheal Tube during Maxillofacial Surgery: A Case Series
We present two cases of nasotracheal tube (NTT) damage suffered during maxillofacial surgery. The different intraoperative conditions led us to decide for the replacement of NTT in one case and for conservative action in the other. The purpose of this article is to highlight the difficulties that the anesthesiologist may have in deciding quickly what is the best approach in case the endotracheal tube is damaged during maxillofacial surgery and possibly try to provide a rapid and safe solution for the situation. (Source: Advances in Therapy)
Source: Advances in Therapy - May 7, 2019 Category: Drugs & Pharmacology Source Type: research

Multiple Sclerosis Performance Test: Technical Development and Usability
ConclusionPatients with MS with varying disability levels completed the MSPT with minimal or no supervision, resulting in comprehensive, efficient, standardized, quantitative, clinically meaningful data collection as part of routine medical care, thus allowing for large-scale, real-world evidence generation.FundingBiogen.Trial RegistrationNCT02664324. (Source: Advances in Therapy)
Source: Advances in Therapy - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Comparing the Efficacy and Safety of High-Intensity Focused Ultrasound and Uterine Artery Embolization in Caesarean Scar Pregnancy: A Meta-analysis
AbstractIntroductionHigh-intensity focused ultrasound (HIFU) followed by curettage and uterine artery embolization (UAE) followed by curettage are two methods of treatment for caesarean scar pregnancy (CSP). There is currently no consistent evidence concerning any difference in efficacy and safety between UAE and HIFU. Therefore, a meta-analysis was performed to compare the efficacy and safety of HIFU and UAE in the treatment of CSP.MethodsStudies published in PubMed, Cochrane, Embase, Web of Science, Chinese BioMedical Literature Service System, and Chinese National Knowledge Infrastructure databases were searched and the...
Source: Advances in Therapy - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Clinical Application of LC –MS/MS in the Follow-Up for Treatment of Children with Methylmalonic Aciduria
AbstractIntroductionTo explore the value of high-performance liquid chromatography –tandem mass spectrometry (LC–MS/MS) in the follow-up for treatment of children with methylmalonic aciduria (MMA).MethodsMethylmalonic acid (MMA), 2-methylcitric acid (MCA) and homocysteine (Hcy) were detected by LC –MS/MS in a total of 1016 samples whose estimated 0.5th and 99.5th percentiles was taken as the reference value. The samples of children with MMA and propionic aciduria (PA) who were followed up in our hospital from January 2017 to August 2018 were collected. Samples of dried blood spots, serum, a nd urine were ...
Source: Advances in Therapy - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of a Community Pharmacist-Delivered Information Program on the Follow-up of Type-2 Diabetic Patients: A Cluster Randomized Controlled Study
AbstractIntroductionLow-quality communication between patients and care providers and limited patient knowledge of the disease and the therapy are important factors associated with poor glycemic control in patients with type 2 diabetes. We conducted a multicenter study to determine whether structured and tailored information delivered by pharmacists to type 2 diabetic patients could improve patient treatment adherence, hemoglobin A1c (HbA1c) levels and knowledge about diabetes.MethodsOne hundred seventy-four pharmacies were randomized to deliver an educational program on diet, drug treatment, disease and complications duri...
Source: Advances in Therapy - May 2, 2019 Category: Drugs & Pharmacology Source Type: research

Differentiating Basal Insulin Preparations: Understanding How They Work Explains Why They Are Different
Abstract Since the introduction of insulin as a life-saving agent for patients with type 1 diabetes, insulin preparations have evolved to approximate physiologic insulin delivery profiles to meet prandial and basal insulin needs. While prandial insulins are designed to have quick time –action profiles that minimize postprandial glucose excursions, basal insulins are designed to have a protracted time–action profile to facilitate basal glucose control over 24 h. Given that all insulins have the same mechanism of action at the target tissue level, the differences in time–act ion profiles are achieved...
Source: Advances in Therapy - April 27, 2019 Category: Drugs & Pharmacology Source Type: research

Economic Burden of Illness Among Commercially Insured Patients with Systemic Sclerosis with Interstitial Lung Disease in the USA: A Claims Data Analysis
This study assessed and compared healthcare resource utilization (HRU), direct healthcare costs, work loss, and indirect costs between patients with SSc-ILD and matched controls with neither SSc nor ILD in the USA.MethodsData were obtained from a large US commercial claims database (2005 –2015). Patients (at least 18 years old) had at least one SSc diagnosis in the inpatient (IP) or emergency room (ER) setting or at least two SSc diagnoses in another setting, and at least one diagnosis of ILD in the IP or ER setting or at least two diagnoses of ILD in another setting. Controls wi th neither SSc nor ILD were matc...
Source: Advances in Therapy - April 27, 2019 Category: Drugs & Pharmacology Source Type: research

Response Letter Addressing Letter to the Editor Regarding Gottschlich S, R öschmann K, Candler H. Adv Ther (2018); 35:1023–1034. doi:10.1007/s12325-018-0736-7
(Source: Advances in Therapy)
Source: Advances in Therapy - April 27, 2019 Category: Drugs & Pharmacology Source Type: research