Beneficial Effects of a Perindopril/Indapamide Single-Pill Combination in Hypertensive Patients with Diabetes and/or Obesity or Metabolic Syndrome: A Post Hoc Pooled Analysis of Four Observational Studies
AbstractIntroductionTo assess real-life effectiveness of a perindopril/indapamide (Per/Ind) single-pill combination (SPC) in patients with hypertension (HT) and type  2 diabetes mellitus (T2DM), obesity and/or metabolic syndrome (MetS).MethodsThis post hoc analysis pooled raw data from four large observational studies (FORTISSIMO, FORSAGE, ACES, PICASSO). Patients, most with uncontrolled blood pressure (BP) on previous treatments were switched to Per/Ind (10  mg/2.5 mg) SPC at study entry. Office systolic and diastolic blood pressures (SBP and DBP) were measured at baseline, 1 month and 3 months.Re...
Source: Advances in Therapy - February 25, 2021 Category: Drugs & Pharmacology Source Type: research

Phase  2 Randomized Clinical Study of Netarsudil Ophthalmic Solution in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension
AbstractIntroductionNetarsudil reduces intraocular pressure (IOP) by increasing aqueous outflow through the trabecular meshwork (TM) pathway and decreasing episcleral venous pressure. The primary objective of this phase  2 study was to evaluate ocular hypotensive efficacy and safety of three netarsudil concentrations (0.01%, 0.02%, and 0.04%) relative to its placebo over 4 weeks in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT).MethodsPatients were randomized to one of four treatment arms, netarsudil ophthalmic solution 0.01%, 0.02%, 0.04%, or placebo, and treated once-dail...
Source: Advances in Therapy - February 24, 2021 Category: Drugs & Pharmacology Source Type: research

Translating iGlarLixi Evidence for the Management of Frequent Clinical Scenarios in Type 2 Diabetes
AbstractTreatment of type 2 diabetes (T2D) requires progressive therapy intensification to reach and maintain individualized glycemic targets. iGlarLixi, a fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide (Lixi), has been shown to provide robust HbA1c reductions allowing more people to reach HbA1c targets compared with separate administration of iGlar or Lixi. The purpose of this review is to help clinicians understand treatment intensification using iGlarLixi by presenting typical clinical scenarios supported by research evidence. These cases will focus on individuals with T2D inadequately con...
Source: Advances in Therapy - February 23, 2021 Category: Drugs & Pharmacology Source Type: research

Beneficial Effects of Intravenous Magnesium Administration During Robotic Radical Prostatectomy: A Randomized Controlled Trial
ConclusionThere is a possibility that intravenous magnesium administration during robotic radical prostatectomy reduces the increases in arterial pressure, cortisol concentrations, opioid requirements, and postoperative pain.Trial RegistrationClinicalTrials.gov identifier, NCT02833038 (Source: Advances in Therapy)
Source: Advances in Therapy - February 21, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: Risk Factors for Prognosis in Elderly Patients with Severe Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study
The original article has published with incorrect dates in the section of patients of methods. (Source: Advances in Therapy)
Source: Advances in Therapy - February 18, 2021 Category: Drugs & Pharmacology Source Type: research

Guidelines Have a Key Role in Driving HCV Elimination by Advocating for Simple HCV Care Pathways
AbstractThe availability of pangenotypic direct-acting antivirals for treatment of hepatitis  C (HCV) has provided an opportunity to simplify patient pathways. Recent clinical practice guidelines have recognised the need for simplification to ensure that elimination of HCV as a public health concern remains a priority. Despite the move towards simplified treatment algorithms, there remains some complexity in the recommendations for the management of genotype 3 patients with compensated cirrhosis. In an era where additional clinical trial data are not anticipated, clinical guidance should consider experience gaine...
Source: Advances in Therapy - February 16, 2021 Category: Drugs & Pharmacology Source Type: research

HCV Viral Load Greater Than 1000  IU/ml at Time of Virologic Failure in Direct-Acting Antiviral-Treated Patients
ConclusionsAt PTW12, 100% of virologic failures had an HCV RNA  >  3.0 log10 IU/ml. The data are encouraging that with a LLOD of 3.0 log10 IU/ml, a point-of-care test could identify all treatment failures accurately; larger studies, including real-world data, are needed to confirm these findings. (Source: Advances in Therapy)
Source: Advances in Therapy - February 15, 2021 Category: Drugs & Pharmacology Source Type: research

Global Quality Statements on Reliever Use in Asthma in Adults and Children Older than 5  Years of Age
ConclusionsThe steering group proposes quality statements that national and local clinical groups can implement as quantitative quality standards that are appropriate to their local circumstances, including during the coronavirus disease  2019 (Covid-19) pandemic. By translating these statements into locally relevant quality standards, primary care physicians and HCPs can encourage optimal management and reduce preventable healthcare interactions. The evidence-based evolution of care encapsulated in these statements will further en gender high-quality, patient-centered holistic management that addresses asthma as an i...
Source: Advances in Therapy - February 14, 2021 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Glucagon-Like Peptide  1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus: A Network Meta-analysis
ConclusionRegimens of GLP-1RAs had differential glycemic control and cardiometabolic effectiveness. Policymaking and patient-centric clinical decisions should take into consideration the comparative effectiveness profiles. (Source: Advances in Therapy)
Source: Advances in Therapy - February 13, 2021 Category: Drugs & Pharmacology Source Type: research

Preoperative Anemia Treatment with Intravenous Iron Therapy in Patients Undergoing Abdominal Surgery: A Systematic Review
ConclusionOverall, these findings are consistent in that IV iron administration is highly effective  at rapidly increasing hemoglobin levels in patients with iron deficiency anemia undergoing major abdominal surgery. Unfortunately, there is currently no evidence of reduced incidence of allogeneic blood transfusions or other enhanced outcomes. (Source: Advances in Therapy)
Source: Advances in Therapy - February 12, 2021 Category: Drugs & Pharmacology Source Type: research

Extraperitoneal Laparoscopic Kidney Transplantation: Preliminary Clinical Experiences from China
ConclusionsExtraperitoneal laparoscopic kidney transplantation, either allograft or autologous transplantation, is a safe and feasible procedure with a good chance of survival for the transplanted kidney. A customised cooling device is effective and practical during laparoscopic kidney transplantation. (Source: Advances in Therapy)
Source: Advances in Therapy - February 12, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics and Pharmacodynamics of Esomeprazole/Sodium Bicarbonate Immediate-Release Capsules in Healthy Chinese Volunteers: A Cross-Over, Randomized Controlled Trial
AbstractIntroductionEsomeprazole delayed release tablets (ESO) are one of the most effective treatments for acid-related disorders. The purpose of this study is to compare the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of an immediate-release capsule formulation containing esomeprazole 20  mg and sodium bicarbonate 1100 mg (IR-ESO) compared to those of the esomeprazole delayed release tablet 20 mg (ESO). In addition, the impact ofCYP2C19 gene polymorphisms on PK and PD was evaluated.MethodsA single-center, open-label, randomized, 2-treatment, 2-sequence, and 2-period crossover study was conducte...
Source: Advances in Therapy - February 11, 2021 Category: Drugs & Pharmacology Source Type: research

Radiotherapy-Specific Chronic Pain Syndromes in the Cancer Population: An Evidence-Based Narrative Review
AbstractWhile radiation therapy is increasingly utilized in the treatment paradigm of many solid cancers, the chronic effects of radiation therapies are poorly characterized. Notably, understanding radiation-specific chronic pain syndromes is paramount given that the diagnosis and management of these conditions can serve to prevent long-standing functional impairments, optimize quality of life, and even allow for continued radiotherapy candidacy. These radiation-specific chronic pain phenomena include dermatitis, mucositis, enteritis, connective tissue fibrosis, lymphedema, and neuropathic pain syndromes. It is necessary t...
Source: Advances in Therapy - February 11, 2021 Category: Drugs & Pharmacology Source Type: research

Cost-Effectiveness Analysis of Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Metastatic Colorectal Cancer in the USA
ConclusionBEC and EC were not cost-effective regimens for patients with pre-treated mCRC withBRAF V600E mutation. (Source: Advances in Therapy)
Source: Advances in Therapy - February 10, 2021 Category: Drugs & Pharmacology Source Type: research

A Japanese Study Assessing Glycemic Control with Use of IDegAsp Co-formulation in Patients with Type  2 Diabetes in Clinical Practice: The JAGUAR Study
AbstractIntroductionThe aim of this study was to evaluate the glycemic control and safety of insulin degludec/insulin aspart (IDegAsp) co-formulation in Japanese patients with type  2 diabetes (T2D) in a real-world clinical setting, including elderly patients (aged >  75 years).MethodsPatients ( ≥ 18 years) diagnosed with T2D, previously treated with insulin were included from the Japanese Medical Data Vision database. Baseline data were taken at the index date, defined as the first IDegAsp prescription claim. Change in glycated hemoglobin (HbA1c) at 12  months was estimated u...
Source: Advances in Therapy - February 9, 2021 Category: Drugs & Pharmacology Source Type: research

Augmentation in Healthcare Utilization of Patients with Opioid Use Disorder After Methadone Maintenance Treatment: A Retrospective Nationwide Study
ConclusionMMT is associated with increased healthcare utilization, and departments of psychiatry and infectious diseases play substantial roles. Policy-makers should warrant access for all who need healthcare by ensuring the availability of the treatment for drug dependence. (Source: Advances in Therapy)
Source: Advances in Therapy - February 8, 2021 Category: Drugs & Pharmacology Source Type: research

Psychosocial Comorbidities and Health Status Among Adults with Moderate-to-Severe Atopic Dermatitis: A 2017 US National Health and Wellness Survey Analysis
AbstractIntroductionAtopic dermatitis (AD) is associated with sleep difficulties, depression, and anxiety. We evaluated the relationship between these psychosocial comorbidities and health outcomes among adults with moderate-to-severe AD in the USA.MethodsData were analyzed from the 2017 US National Health and Wellness Survey. Respondents with a physician diagnosis of AD or eczema with moderate-to-severe AD based on a Dermatology Life Quality Index score of 6 or more were included. Generalized linear models were used to examine the relationship between psychosocial comorbidities (sleep difficulties and anxiety based on sel...
Source: Advances in Therapy - February 8, 2021 Category: Drugs & Pharmacology Source Type: research

Database Analysis on the Relationships Between Nonsteroidal Anti-inflammatory Drug Treatment Variables and Incidence of Acute Myocardial Infarction in Japanese Patients with Osteoarthritis and Chronic Low Back Pain
ConclusionIn Japanese patients with OA and CLBP, we saw a trend of increased risk for AMI in patients using NSAIDs for more than 5  years. Elderly patients had a higher prevalence of diabetes, hypertension, and other CVD which increased the risk of AMI. Although NSAID patches were preferred to oral NSAIDs in elderly patients, risk for AMI was similar between the two modalities. Therefore, we suggest using NSAIDs carefully, esp ecially in elderly patients and those at risk of developing CVD. (Source: Advances in Therapy)
Source: Advances in Therapy - February 5, 2021 Category: Drugs & Pharmacology Source Type: research

Onset, Maintenance, and Cessation of Effect of Galcanezumab for Prevention of Migraine: A Narrative Review of Three Randomized Placebo-Controlled Trials
ConclusionGalcanezumab is a novel preventive therapeutic option for adult patients with migraine that has early onset of action, maintenance of effect, and gradual reduction of effect upon treatment cessation.Trial RegistrationClinicalTrials.gov: NCT02614183 (EVOLVE-1); NCT02614196 (EVOLVE-2); NCT02614261 (REGAIN). (Source: Advances in Therapy)
Source: Advances in Therapy - February 5, 2021 Category: Drugs & Pharmacology Source Type: research

Clinical Impact of Adherence to NCCN Guidelines for Biomarker Testing and First-Line Treatment in Advanced Non-Small Cell Lung Cancer (aNSCLC) Using Real-World Electronic Health Record Data
This study aimed to assess the association between adherence to National Comprehensive Cancer Network (NCCN) guidelines and clinical outcomes for adult patients with advanced non-small-cell lung cancer (aNSCLC).MethodsThis was a retrospective cohort study of adult patients with aNSCLC (stages IIIB, IIIC, and IV) from a de-identified real-world database. The objective was accomplished in a two-step analysis process. We first assessed adherence to NCCN recommendations for biomarker testing and overall survival (OS). Next, we assessed adherence to NCCN-recommended first-line therapy and time to treatment discontinuation (TTD)...
Source: Advances in Therapy - February 4, 2021 Category: Drugs & Pharmacology Source Type: research

Efficacy of Agomelatine 25 –50 mg for the Treatment of Anxious Symptoms and Functional Impairment in Generalized Anxiety Disorder: A Meta-Analysis of Three Placebo-Controlled Studies
ConclusionThis meta-analysis confirms that agomelatine reduces anxiety symptoms and improves the global functioning of GAD patients. (Source: Advances in Therapy)
Source: Advances in Therapy - February 4, 2021 Category: Drugs & Pharmacology Source Type: research

A Prospective, Observational, Cohort Study to Assess the Efficacy and Safety of Prolonged-Release Fampridine in Cognition, Fatigue, Depression, and Quality of Life in Multiple Sclerosis Patients: The FAMILY Study
The objective of this study was to evaluate the effect of PR-FAM treatment on cognition, fatigue, depression, and quality of life (QoL) in adult patients with MS in a real-world setting.MethodsFAMILY was a multi-center, prospective, observational, real-world cohort study of MS patients receiving PR-FAM in the outpatient setting. Patients were treated as per PR-FAM ’s local prescribing information for 6 months. Standardized protocols and questionnaires were used to evaluate changes in cognition (PASAT; Paced Auditory Serial Addition Test), fatigue (MFIS; Modified Fatigue Impact Scale), depression (BDI-II; Beck De...
Source: Advances in Therapy - February 2, 2021 Category: Drugs & Pharmacology Source Type: research

Real-World Prescription Pattern and Healthcare Cost Among Patients with Ulcerative Colitis in Japan: A Retrospective Claims Data Analysis
ConclusionPrescription pattern in Japanese patients with UC enrolled in the JMDC database were largely consistent with the clinical guidelines in Japan. UC puts a substantial economic burden on patients, and an effective treatment is warranted to reduce the UC disease burden. (Source: Advances in Therapy)
Source: Advances in Therapy - January 30, 2021 Category: Drugs & Pharmacology Source Type: research

Benefit of Early Add-on of Linagliptin to Insulin in Japanese Patients With Type 2 Diabetes Mellitus: Randomized-Controlled Open-Label Trial (TRUST2)
ConclusionsAdd-on of linagliptin to insulin was tolerated, improved glycemic control, and reduced the daily insulin dose. This study demonstrates the long-term safety, efficacy and benefit of early add-on of linagliptin to insulin in Japanese T2DM patients. (Source: Advances in Therapy)
Source: Advances in Therapy - January 28, 2021 Category: Drugs & Pharmacology Source Type: research

Rosacea, Germs, and Bowels: A Review on Gastrointestinal Comorbidities and Gut –Skin Axis of Rosacea
AbstractRosacea is a chronic inflammatory disease with complicated pathophysiology that involves genetic and environmental elements and dysregulation of innate and adaptive immunity, neurovascular responses, microbiome colonization or infection, resulting in recurrent inflammation. Rosacea has been reported associated with various gastrointestinal diseases including inflammatory bowel disease, celiac disease, irritable bowel syndrome, gastroesophageal reflux disease,Helicobacter pylori (HP) infection, and small intestine bacterial overgrowth (SIBO). The link may involve common predisposing genetic, microbiota, and immunolo...
Source: Advances in Therapy - January 28, 2021 Category: Drugs & Pharmacology Source Type: research

Sulodexide for Diabetic-Induced Disabilities: A Systematic Review and Meta-Analysis
ConclusionSulodexide has a beneficial effect on the ocular, peripheral arterial disease, trophic ulcers, and renal complications of diabetes without increasing the risk of AEs. (Source: Advances in Therapy)
Source: Advances in Therapy - January 27, 2021 Category: Drugs & Pharmacology Source Type: research

Comparison Between Fusion and Non-Fusion Surgery for Lumbar Spinal Stenosis: A Meta-analysis
AbstractIntroductionA large number of studies have shown that, for severe lumbar spinal stenosis, decompression surgery can often obtain better results than non-surgical treatment. However, whether the lumbar spine is fixed after decompression is still controversial. The results of biomechanical studies indicate that there is a correlation between the range of decompression and postoperative spinal instability.MethodsThe multiple databases like Pubmed, Embase, Cochrane databases and China National Knowledge database were used to search for the relevant studies, and full-text articles involved in the evaluation of fusion an...
Source: Advances in Therapy - January 24, 2021 Category: Drugs & Pharmacology Source Type: research

Effectiveness of Eribulin in Metastatic Breast Cancer: 10 Years of Real-World Clinical Experience in the United States
ConclusionThe current retrospective chart review study reinforces the clinical effectiveness of eribulin in patients with MBC, including those with TNBC, when used according to the approved US indication in real-world clinical practice. (Source: Advances in Therapy)
Source: Advances in Therapy - January 24, 2021 Category: Drugs & Pharmacology Source Type: research

The Myth of Mild: Severe Exacerbations in Mild Asthma: An Underappreciated, but Preventable Problem
AbstractAsthma is a common, chronic inflammatory airway disease, characterised by unpredictable episodes of worsening symptoms, or exacerbations. Causes of asthma exacerbations include viral infections, exposure to allergen and air pollution, all of which increase the underlying inflammation that typifies asthma. Most (50 –75%) patients are classed as having mild asthma, with symptoms that can be readily controlled with available inhaled medications. Paradoxically, for the past 30 years, the first treatment recommended in asthma management guidelines was short-acting β2-agonists (SABA), which not only have ...
Source: Advances in Therapy - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Clinical Outcomes and Healthcare Resource Utilization in a Real-World Population Reflecting the DAPA-CKD Trial Participants
ConclusionThe significant adverse renal and cardiovascular outcomes observed, particularly in the DAPA-CKD-like cohort, represent a substantial burden resulting in increased mortality, HCRU and costs, demonstrating the need for additional treatment options. (Source: Advances in Therapy)
Source: Advances in Therapy - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Evaluation of Cardiac Repolarization in the Randomized Phase 2 Study of Intermediate- or High-Risk Smoldering Multiple Myeloma Patients Treated with Daratumumab Monotherapy
ConclusionAnalysis of ECG intervals and concentration-QTc relationships showed a small but clinically insignificant effect of daratumumab.Trial RegistrationClinicalTrials.gov Identifier: NCT02316106. (Source: Advances in Therapy)
Source: Advances in Therapy - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Utility of Screening Fasting Plasma Glucose and Glycated Hemoglobin to Circumvent the Need for Oral Glucose Tolerance Test in Women with Prior Gestational Diabetes
ConclusionsThe proposed strategies are likely to be both patient- and physician-friendly and have the potential to address several barriers for postpartum screening among women with prior GDM. (Source: Advances in Therapy)
Source: Advances in Therapy - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

Post Abortion Care and Management After Induced Abortion During the COVID-19 Pandemic: A Chinese Expert Consensus
AbstractThe rapid spread of novel coronavirus (COVID-19) has posed complex challenges to global public health. During this pandemic period, access to essential services including post-abortion care (PAC) has been disrupted. Along with the clinical management of the disease in women, protection of the healthcare workers and medical staff from nosocomial infection is important to ensure infection control. Thus, in order to implement the proper contraceptive measures and to reduce the rate of repeated abortion, the family planning group of minimally invasive gynecological branch of the Liaoning Medical Association organized...
Source: Advances in Therapy - January 18, 2021 Category: Drugs & Pharmacology Source Type: research

Correction to: A Global Survey of Disease Burden in Patients Who Carry a Diagnosis of Chronic Inflammatory Demyelinating Polyneuropathy
The original article is published with few errors. (Source: Advances in Therapy)
Source: Advances in Therapy - January 13, 2021 Category: Drugs & Pharmacology Source Type: research

The Impact of Progression on Healthcare Resource Utilization and Costs Among Patients with High-Grade Non-Muscle Invasive Bladder Cancer After Bacillus Calmette-Gu érin Therapy: A Retrospective SEER-Medicare Analysis
AbstractIntroductionWe evaluated the real-world healthcare resource utilization (HRU) and costs among patients with high-grade non-muscle invasive bladder cancer (HG-NMIBC) following Bacillus Calmette-Gu érin (BCG) therapy.MethodsPatients aged  ≥ 65 years diagnosed with HG-NMIBC between 2008 and 2015 who received adequate BCG induction and were identified in the SEER-Medicare database. Those who received intravesical chemotherapy or radical cystectomy within 12 months of the last BCG induction dose, and had ≥ 6 months of data a vailability after treatment (index date), were i...
Source: Advances in Therapy - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Body Mass Index Variable Interpolation to Expand the Utility of Real-world Administrative Healthcare Claims Database Analyses
ConclusionThis study demonstrated the feasibility and validity of using ML algorithms to predict BMI classifications in administrative healthcare claims data to expand the utility for RWE generation. (Source: Advances in Therapy)
Source: Advances in Therapy - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Patient and Healthcare Provider Perspectives of First-Generation Somatostatin Analogs in the Management of Neuroendocrine Tumors and Acromegaly: A Systematic Literature Review
ConclusionsStudy outcomes favored LAN in this SLR, with factors surrounding injection administration most influential in treatment experience. The findings of this SLR provide a basis that could inform development of decision-making criteria, with patient and HCP treatment perspectives considered. Future studies should utilize a common method to report preference and associated drivers. (Source: Advances in Therapy)
Source: Advances in Therapy - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Costs and Healthcare Resource Use Associated with Risk of Cardiovascular Morbidity in Patients with Chronic Kidney Disease: Evidence from a Systematic Literature Review
ConclusionRisks of adverse clinical outcomes increase with CKD and albuminuria severity and are associated with substantial additional costs and resource utilisation. Thus, early diagnosis and proactive management of CKD and its complications should be a priority for healthcare providers to alleviate the burden of CV morbidity and its management on healthcare resources. (Source: Advances in Therapy)
Source: Advances in Therapy - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): A Multicenter Post-marketing Surveillance Study
This study aimed to evaluate the safety and effectiveness of biosimilar etanercept (Altebrel, AryoGen Co., Iran) in patients with rheumatoid arthritis (RA), ankylosing spondyliti s (AS), and psoriatic arthritis (PsA).MethodsIn this open-label, multicenter, prospective, observational, post-marketing surveillance study, 583 patients received biosimilar etanercept 25  mg twice weekly or 50 mg once weekly and were followed up to 12 months. The primary objective was to evaluate the safety of biosimilar etanercept by documenting all the adverse events in the case report forms throughout the study period. The secon...
Source: Advances in Therapy - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

Vardenafil in the Treatment of Male Erectile Dysfunction: A Systematic Review and Meta-Analysis
ConclusionsVardenafil demonstrated significant efficacy in the treatment of ED, but the optimal dose and course of vardenafil remain to be established. (Source: Advances in Therapy)
Source: Advances in Therapy - January 11, 2021 Category: Drugs & Pharmacology Source Type: research

The Effects of Acarbose on Non-Diabetic Overweight and Obese Patients: A Meta-Analysis
ConclusionAcarbose monotherapy is beneficial in reducing TG levels in obese or overweight patients and will not result in hypoglycemia during medication. The side effects of acarbose are mild. (Source: Advances in Therapy)
Source: Advances in Therapy - January 9, 2021 Category: Drugs & Pharmacology Source Type: research

Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future
AbstractThe key clinical attributes of preserved dorzolamide/timolol fixed combination (DTFC) and the emerging potential of preservative-free (PF) DTFC are reviewed with published evidence and clinical experience. The indications and role of DTFC in current glaucoma management are critically discussed. Preserved DTFC became the first intraocular pressure (IOP)-lowering fixed combination (FC) approved by the US Food and Drug Administration (FDA) and remains one of most commonly used medications worldwide. The pharmacological properties of DTFC reflect those of its two time-tested constituents, i.e., the carbonic anhydrase i...
Source: Advances in Therapy - January 1, 2021 Category: Drugs & Pharmacology Source Type: research

Recombinant FVIIIFc Versus BAY 94-9027 for Treatment of Patients with Haemophilia  A: Comparative Efficacy Using a Matching Adjusted Indirect Comparison
ConclusionsThis indirect treatment comparison indicates a statistically significant and clinically relevant difference in ABR favouring individualised prophylaxis with rFVIIIFc versus BAY 94-9027 prophylaxis. The proportion of patients with zero bleeds was numerically greater with rFVIIIFc treatment but did not achieve statistical significance. (Source: Advances in Therapy)
Source: Advances in Therapy - December 30, 2020 Category: Drugs & Pharmacology Source Type: research

Comparison of Prognostic Value of Red Cell-Related Parameters of Biliary Tract Cancer After Surgical Resection and Integration of a Prognostic Nomogram: A Retrospective Study
ConclusionHALP was a superior red blood cell-related parameter and an independent predictor of prognosis. Our nomogram based on HALP, tumour-node-metastasis staging, and operative outcome is a promising model for predicting overall survival. (Source: Advances in Therapy)
Source: Advances in Therapy - December 26, 2020 Category: Drugs & Pharmacology Source Type: research

A Retrospective Chart Review Study of Real-World Use of Talimogene Laherparepvec in Unresectable Stage  IIIB–IVM1a Melanoma in Four European Countries
ConclusionThis study is the first comprehensive multinational evaluation of the use of T-VEC to treat unresectable stage  IIIB/C–IVM1a melanoma in real-world clinical practice in Europe. The differences between European countries were apparent, with physicians in the Netherlands using T-VEC in patients with earlier advanced disease stage and in the first-line setting compared with other countries. (Source: Advances in Therapy)
Source: Advances in Therapy - December 26, 2020 Category: Drugs & Pharmacology Source Type: research

Estimated Impact of Public and Private Sector COVID-19 Diagnostics and Treatments on US Healthcare Resource Utilization
ConclusionWhile mechanisms exist to facilitate research, development, and patient access to diagnostic testing, future policies should focus on ensuring equitable patient access to both diagnostic testing and treatments that, in turn, will alleviate COVID-19-related resource constraints. (Source: Advances in Therapy)
Source: Advances in Therapy - December 26, 2020 Category: Drugs & Pharmacology Source Type: research

Therapeutic Efficacy of a Coriolus versicolor -Based Vaginal Gel in Women with Cervical Uterine High-Risk HPV Infection: A Retrospective Observational Study
AbstractIntroductionACoriolus versicolor-based vaginal gel is available for treating women with cervical uterine high-risk human papillomavirus (HPV) infection through re-epithelizing and re-balancing microbiota actions.MethodsA longitudinal retrospective observational study was performed to evaluate efficacy and safety of the gel. Women treated withCoriolus versicolor-based vaginal gel were compared with women not treated with the gel. Both groups were monitored for HPV infection by an HPV DNA test, Pap smear (cytology) and colposcopy at baseline and after 6  months.ResultsOverall, 183 high-risk HPV positive women we...
Source: Advances in Therapy - December 26, 2020 Category: Drugs & Pharmacology Source Type: research

Renal Tubular Acidosis and Management Strategies: A Narrative Review
AbstractRenal tubular acidosis (RTA) occurs when the kidneys are unable to maintain normal acid −base homeostasis because of tubular defects in acid excretion or bicarbonate ion reabsorption. Using illustrative clinical cases, this review describes the main types of RTA observed in clinical practice and provides an overview of their diagnosis and treatment. The three major forms of RTA are d istal RTA (type 1; characterized by impaired acid excretion), proximal RTA (type 2; caused by defects in reabsorption of filtered bicarbonate), and hyperkalemic RTA (type 4; caused by abnormal excretion of acid and...
Source: Advances in Therapy - December 26, 2020 Category: Drugs & Pharmacology Source Type: research

Effect of Levothyroxine on Kidney Function in Chronic Kidney Disease with Subclinical Hypothyroidism in US Veterans: A Retrospective Observational Cohort Study
AbstractIntroductionChronic kidney disease (CKD) may be associated with overt or subclinical hypothyroidism [SCH; defined as elevated serum thyroid-stimulating hormone (TSH) despite normal free thyroxine levels). Although some studies have demonstrated that thyroid replacement therapy may improve renal function in overt hypothyroidism, there is no consensus on its benefits in SCH. Clinical and limited economic outcomes were evaluated in levothyroxine-treated US veterans with CKD  + SCH.MethodsVeterans Health Administration claims data from April 2013 to March 2018 for levothyroxine-treated versus nontreated C...
Source: Advances in Therapy - December 23, 2020 Category: Drugs & Pharmacology Source Type: research

Asthma and Chronic Obstructive Pulmonary Disease Overlap According to the Japanese Respiratory Society Diagnostic Criteria: The Prospective, Observational ACO Japan Cohort Study
AbstractIntroductionPatients with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) present with chronic respiratory symptoms with features of both asthma and COPD. New ACO diagnostic criteria (2018) were suggested by the Japanese Respiratory Society (JRS). This prospective, multicenter, observational cohort study was conducted to investigate the proportion of patients who meet the JRS ACO diagnostic criteria among COPD patients in clinical practice.MethodsThis 2-year ongoing study enrolled consecutive outpatients aged  ≥ 40 years with COPD who visited one of 27 Japanese centers at whi...
Source: Advances in Therapy - December 23, 2020 Category: Drugs & Pharmacology Source Type: research