SRF Expression in Excess Permits a Dual Contractile-Proliferative Phenotype of Airway Smooth Muscle
Am J Respir Cell Mol Biol. 2024 May 22. doi: 10.1165/rcmb.2024-0081OC. Online ahead of print.ABSTRACTThe transcription factors (TFs) myocardin (MyoCD) and ETS Like-1 protein (Elk-1) competitively bind to serum response factor (SRF) and control myogenic- and mitogenic-related gene expression in smooth muscle, respectively. Their functions are therefore mutually inhibitory, which result in a contractile versus proliferative phenotype dichotomy. Airway smooth muscle cell (ASMC) phenotype alterations occur in various inflammatory airway diseases, promoting pathological remodelling and contributing to airflow obstruction. We ch...
Source: Am J Respir Cell Mol... - May 22, 2024 Category: Respiratory Medicine Authors: Rui Sun Xingning Pan Erin Ward Rafael Intrevado Arina Morozan Anne-Marie Lauzon James G Martin Source Type: research

Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity
Am J Respir Cell Mol Biol. 2024 May 20. doi: 10.1165/rcmb.2023-0332OC. Online ahead of print.ABSTRACTMechanical ventilation contributes to the morbidity and mortality of patients in Intensive Care, likely through the exacerbation and dissemination of inflammation. Despite its proximity to the lungs and exposure to physical forces, little attention has been paid to the potential of the pleural cavity as an inflammatory source during ventilation. Here we investigate the pleural cavity as a novel site of inflammation during ventilator-induced lung injury. Mice were subjected to low or high tidal volume ventilation strategies ...
Source: Am J Respir Cell Mol... - May 20, 2024 Category: Respiratory Medicine Authors: Rhianna F Baldi Marissa W Koh Chubicka Thomas Tomasz Sabbat Bincheng Wang Stefania Tsatsari Kieron Young Alexander Wilson-Slomkowski Sanooj Soni Kieran P O'Dea Brijesh V Patel Masao Takata Michael R Wilson Source Type: research

Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity
Am J Respir Cell Mol Biol. 2024 May 20. doi: 10.1165/rcmb.2023-0332OC. Online ahead of print.ABSTRACTMechanical ventilation contributes to the morbidity and mortality of patients in Intensive Care, likely through the exacerbation and dissemination of inflammation. Despite its proximity to the lungs and exposure to physical forces, little attention has been paid to the potential of the pleural cavity as an inflammatory source during ventilation. Here we investigate the pleural cavity as a novel site of inflammation during ventilator-induced lung injury. Mice were subjected to low or high tidal volume ventilation strategies ...
Source: Am J Respir Cell Mol... - May 20, 2024 Category: Respiratory Medicine Authors: Rhianna F Baldi Marissa W Koh Chubicka Thomas Tomasz Sabbat Bincheng Wang Stefania Tsatsari Kieron Young Alexander Wilson-Slomkowski Sanooj Soni Kieran P O'Dea Brijesh V Patel Masao Takata Michael R Wilson Source Type: research

Indole-3-Acetic Acid Protects Against Lipopolysaccharide-induced Endothelial Cell Dysfunction and Lung Injury through the Activation of USP40
In this study, we investigated the role of IAA in lung endothelial cell function in the context of acute lung injury. IAA exhibited EC barrier protection against LPS-induced reduction in transendothelial electrical resistance (TEER) and inflammatory responses. The underlying mechanism of IAA on EC protective effects were investigated by examining the influence of IAA on levels of HSP90 ubiquitination and USP40 activity. We identified that IAA, acting as a potential activator of USP40, reduces HSP90 ubiquitination, thereby protecting against LPS-induced inflammation in human lung microvascular endothelial cell (HLMVECs) as ...
Source: Am J Respir Cell Mol... - May 18, 2024 Category: Respiratory Medicine Authors: Nargis Shaheen Jiaxing Miao Donna Li Boyu Xia Boina Baoyinna Yutong Zhao Jing Zhao Source Type: research

Indole-3-Acetic Acid Protects Against Lipopolysaccharide-induced Endothelial Cell Dysfunction and Lung Injury through the Activation of USP40
In this study, we investigated the role of IAA in lung endothelial cell function in the context of acute lung injury. IAA exhibited EC barrier protection against LPS-induced reduction in transendothelial electrical resistance (TEER) and inflammatory responses. The underlying mechanism of IAA on EC protective effects were investigated by examining the influence of IAA on levels of HSP90 ubiquitination and USP40 activity. We identified that IAA, acting as a potential activator of USP40, reduces HSP90 ubiquitination, thereby protecting against LPS-induced inflammation in human lung microvascular endothelial cell (HLMVECs) as ...
Source: Am J Respir Cell Mol... - May 18, 2024 Category: Respiratory Medicine Authors: Nargis Shaheen Jiaxing Miao Donna Li Boyu Xia Boina Baoyinna Yutong Zhao Jing Zhao Source Type: research

Unfolding the Role of Th17 Cells in Neutrophilic Lung Inflammation
Am J Respir Cell Mol Biol. 2024 May 15. doi: 10.1165/rcmb.2024-0180ED. Online ahead of print.NO ABSTRACTPMID:38747688 | DOI:10.1165/rcmb.2024-0180ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 15, 2024 Category: Respiratory Medicine Authors: T Parks Remcho Jay K Kolls Source Type: research

Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension Through Orai-Ca2+ Channels
Am J Respir Cell Mol Biol. 2024 May 15. doi: 10.1165/rcmb.2024-0214ED. Online ahead of print.NO ABSTRACTPMID:38749029 | DOI:10.1165/rcmb.2024-0214ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 15, 2024 Category: Respiratory Medicine Authors: Ana ïs Saint-Martin Willer Kristell El Jekmek Fabrice Antigny Source Type: research

Unfolding the Role of Th17 Cells in Neutrophilic Lung Inflammation
Am J Respir Cell Mol Biol. 2024 May 15. doi: 10.1165/rcmb.2024-0180ED. Online ahead of print.NO ABSTRACTPMID:38747688 | DOI:10.1165/rcmb.2024-0180ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 15, 2024 Category: Respiratory Medicine Authors: T Parks Remcho Jay K Kolls Source Type: research

Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension Through Orai-Ca2+ Channels
Am J Respir Cell Mol Biol. 2024 May 15. doi: 10.1165/rcmb.2024-0214ED. Online ahead of print.NO ABSTRACTPMID:38749029 | DOI:10.1165/rcmb.2024-0214ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 15, 2024 Category: Respiratory Medicine Authors: Ana ïs Saint-Martin Willer Kristell El Jekmek Fabrice Antigny Source Type: research

Unfolding the Role of Th17 Cells in Neutrophilic Lung Inflammation
Am J Respir Cell Mol Biol. 2024 May 15. doi: 10.1165/rcmb.2024-0180ED. Online ahead of print.NO ABSTRACTPMID:38747688 | DOI:10.1165/rcmb.2024-0180ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 15, 2024 Category: Respiratory Medicine Authors: T Parks Remcho Jay K Kolls Source Type: research

Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension Through Orai-Ca2+ Channels
Am J Respir Cell Mol Biol. 2024 May 15. doi: 10.1165/rcmb.2024-0214ED. Online ahead of print.NO ABSTRACTPMID:38749029 | DOI:10.1165/rcmb.2024-0214ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 15, 2024 Category: Respiratory Medicine Authors: Ana ïs Saint-Martin Willer Kristell El Jekmek Fabrice Antigny Source Type: research

Unfolding the Role of Th17 Cells in Neutrophilic Lung Inflammation
Am J Respir Cell Mol Biol. 2024 May 15. doi: 10.1165/rcmb.2024-0180ED. Online ahead of print.NO ABSTRACTPMID:38747688 | DOI:10.1165/rcmb.2024-0180ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 15, 2024 Category: Respiratory Medicine Authors: T Parks Remcho Jay K Kolls Source Type: research

Monocytes - See One Queuing Local Adaptive Immune Responses to Respiratory Viruses
Am J Respir Cell Mol Biol. 2024 May 8. doi: 10.1165/rcmb.2024-0195ED. Online ahead of print.NO ABSTRACTPMID:38717817 | DOI:10.1165/rcmb.2024-0195ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 8, 2024 Category: Respiratory Medicine Authors: Alexander P Earhart Hrishikesh S Kulkarni Source Type: research

Monocytes - See One Queuing Local Adaptive Immune Responses to Respiratory Viruses
Am J Respir Cell Mol Biol. 2024 May 8. doi: 10.1165/rcmb.2024-0195ED. Online ahead of print.NO ABSTRACTPMID:38717817 | DOI:10.1165/rcmb.2024-0195ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 8, 2024 Category: Respiratory Medicine Authors: Alexander P Earhart Hrishikesh S Kulkarni Source Type: research

Monocytes - See One Queuing Local Adaptive Immune Responses to Respiratory Viruses
Am J Respir Cell Mol Biol. 2024 May 8. doi: 10.1165/rcmb.2024-0195ED. Online ahead of print.NO ABSTRACTPMID:38717817 | DOI:10.1165/rcmb.2024-0195ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 8, 2024 Category: Respiratory Medicine Authors: Alexander P Earhart Hrishikesh S Kulkarni Source Type: research