Comparison of clinical characteristics of bacteremia from Elizabethkingia meningoseptica and other carbapenem-resistant, non-fermenting Gram-negative bacilli at a tertiary medical center
ConclusionThe mortality rate of E. meningoseptica bacteremia was as high as other carbapenem-resistant NFGNB infections. The emerging E. meningoseptica infection calls for active surveillance and continued awareness from clinical physicians for this serious carbapenem-resistant infection. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 18, 2018 Category: Microbiology Source Type: research

Significant apoptosis rather autophagy predominates in astrocytes caused by TOXOCARA CANIS larval excretory-secretory antigens
ConclusionWe concluded that TcES Ag may trigger astrocytes apoptosis predominantly through intrinsic and extrinsic pathways rather autophagy, revealing a novel role of astrocytes in the pathogenesis of CT. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 12, 2018 Category: Microbiology Source Type: research

Pediatric Kikuchi-Fujimoto disease: A clinicopathologic study and the therapeutic effects of hydroxychloroquine
Publication date: Available online 29 September 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Yung-Chih Lin, Hsiu-Hui Huang, Bao-Ren Nong, Po-Yen Liu, Ying-Yao Chen, Yung-Feng Huang, Yee-Hsuan Chiou, Herng-Sheng LeeAbstractBackgroundTo investigate the clinical features of Kikuchi-Fujimoto disease (KFD) in children, and place an emphasis on the therapeutic effects of hydroxychloroquine as monotherapy.MethodsWe retrospectively reviewed the medical records of all children diagnosed with KFD during the period January 1992 to September 2016 at a tertiary medical center in Taiwan.Results40 patients...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Clinical characteristics and treatment outcomes of vancomycin-resistant Enterococcus faecium bacteremia
Publication date: Available online 5 October 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Jung-Jr Ye, Shian-Sen Shie, Chun-Wen Cheng, Jeng-How Yang, Po-Yen Huang, Ting-Shu Wu, Ming-Hsun Lee, Ching-Tai HuangAbstractBackgroundVancomycin-resistant Enterococcus faecium (VRE-fm) bacteremia causes significant mortality in hospitalized patients. We sought to investigate clinical characteristics, treatment outcomes, and microbiological eradication associated with VRE-fm bacteremia.MethodsA retrospective cohort study was conducted and included 210 adult patients admitted between January 1, 2011 and Decemb...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Humoral immunity to mumps in a highly vaccinated population in Taiwan
Publication date: Available online 7 October 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Yu-Huai Ho, Chen-Chi Tsai, Ya-Wen Tsai, Yu-Chiang Wang, Tzou-Yien Lin, De-Jen Lee, Chih-Jung ChenAbstractBackgroundA resurgence of mumps was noted recently and outbreaks were increasingly reported in populations with high vaccine coverage. We aimed to evaluate the seroprevalence to mumps in Taiwan, where a two-dose childhood mumps-containing vaccine program, with a high coverage rate, had been implemented for>20 years.MethodsThe anti-mumps IgG was determined in 3552 participants of all ages in Taiwan. The...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Prevalence of Pediculus capitis in schoolchildren in Battambang, Cambodia
ConclusionPrimary school children in Cambodia have a high P. capitis infection rate and thus require effective treatment and prevention measures to treat symptoms and lower the infection rate. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Early prosthetic joint infection due to Ureaplasma urealyticum: Benefit of 16S rRNA gene sequence analysis for diagnosis
We report a case of early PJI due to Ureaplasma urealyticum, diagnosed by 16S rRNA gene sequence analysis, which highlights the interest of molecular methods if fastidious bacteria are involved in PJI. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Serotype distribution and clinical correlation of Streptococcus agalactiae causing invasive disease in infants and children in Taiwan
ConclusionIn Taiwan, serotypes Ia and III are the most common cause for early-onset and late-onset neonatal GBS infections, respectively. Some differences in the clinical features of invasive GBS infections caused by serotype Ia and III were observed. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Implementation of a national bundle care program to reduce central line-associated bloodstream infections in intensive care units in Taiwan
This study assessed the effect of the central line bundle on the rate of central line-associated bloodstream infections (CLABSI) in intensive care units (ICUs) in Taiwan.MethodsThis national study was conducted in 27 ICUs with 404 beds total, including 15 medical ICUs, 11 surgical ICUs, and one mixed ICU. The study period was divided into two phases: a pre-intervention (between June 1, 2011 and October 31, 2011) and intervention phase (between December 1, 2011 and October 31, 2012). Outcome variables, including CLABSI rates (per 1000 catheter-days) and catheter utilization rates, were measured.ResultsThe overall rate of CL...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Discrimination of culture negative pyelonephritis in children with suspected febrile urinary tract infection and negative urine culture results
We examined 264 children experiencing their first fUTI consecutively admitted to our hospital between January 2011 and October 2014. Blood tests (CRP, white blood cell count [WBC], erythrocyte sedimentation rate [ESR], electrolytes) and urine tests (urine protein to creatinine ratio [uProt/Cr], electrolytes, uNa/K) were performed upon admission. All children with fUTI underwent 99m-dimercaptosuccinic acid (DMSA) scanning at admission. Data were compared between children with acute pyelonephritis (APN), CNP, lower UTI and controls. Using multiple logistic regression analysis (MLRA), the ability of these parameters to predic...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Purulent pericarditis complicating cardiac tamponade in a uremic patient caused by Staphylococcus aureus
Publication date: Available online 26 October 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Weng-Chio Tam, Wen-Sen Lee, Chung-Yi ChengAbstractPurulent pericarditis complicating cardiac tamponade is rare and associated with high morbidity and mortality. Purulent pericarditis can be caused by bacterial, viral, anaerobic, mycobacterial, fungal, parasitic and protozoal infection. The underlying comorbidities, entry site of the pathogens, and gross appearance of aspirated pericardial fluid can help us to estimate the causative agents of purulent pericarditis. Hence the prompt empiric antibiotic therapy...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Successful treatment by fecal microbiota transplantation for Japanese patients with refractory Clostridium difficile infection: A prospective case series
Publication date: Available online 5 November 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Shigeki Bamba, Atsushi Nishida, Hirotsugu Imaeda, Osamu Inatomi, Masaya Sasaki, Mitsushige Sugimoto, Akira AndohAbstractWe prospectively enrolled four Japanese patients with refractory Clostridium difficile infection (CDI) and were treated with a single fecal microbiota transplantation (FMT). The average age of the patients was 83.7 years. All patients had a successful clinical course for up to 3 months without any adverse events. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Risk-stratified management strategies for HBV reactivation in RA patients receiving biological and targeted therapy: A narrative review
Publication date: Available online 5 November 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Yi-Ming Chen, Sheng-Shun Yang, Der-Yuan ChenAbstractIt is estimated that more than two billion people around the world have been infected by Hepatitis B virus (HBV). Reactivation of HBV (rHBV) is a potentially fatal complication after biological therapy. With the increasing use of biologics and targeted therapy in rheumatoid arthritis (RA) patients who are refractory to conventional synthetic disease-modifying anti-rheumatic drugs, rHBV in those with past infection has become increasingly problematic, espec...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Evaluation of Bruker Biotyper and Vitek MS for the identification of Candida tropicalis on different solid culture media
ConclusionClinical microbiologists should be aware that different culture media can affect the performance of the Bruker Biotyper MALDI-TOF MS and Vitek MS systems in identifying C. tropicalis. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Implementation and outcomes of hospital-wide computerized antimicrobial approval system and on-the-spot education in a traumatic intensive care unit in Taiwan
ConclusionImplementation of HCAAS and long-term on-the-spot education by full-time ID physician can reduce antimicrobial consumption, cost, and improve inappropriate antibiotic usage whilst not compromising healthcare quality. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity
ConclusionOur results show that abolishing the enzymatic activity of SpnA only partially reduces virulence suggesting that SpnA has an additional virulence function, which might be located on the N-terminal domain. Furthermore, cell wall-anchoring of SpnA results in higher virulence compared to secreted SpnA, probably due to a higher local density of the enzyme. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Detection of circulating IgG autoantibody to FcεRIα in sera from chronic spontaneous urticaria patients
ConclusionThese findings suggest that circulating IgG autoantibody to FcεRIα in a subset of patients may be involved in the autoimmune mechanism of CSU. Further studies are needed to clarify its clinical significance. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

National bundle care program implementation to reduce ventilator-associated pneumonia in intensive care units in Taiwan
This study investigated the impact of implementing ventilator-associated pneumonia (VAP) bundle care on the rates of VAP in intensive care units (ICUs) in Taiwan.MethodsA total of 10 ICUs (bed number, 170), including surgical (SICUs) (n = 7), cardiovascular/surgical (CV/S-ICUs) (n = 1), and medical ICUs (MICUs) (n = 2) from 10 hospitals (7 medical center hospitals and 3 regional hospitals) were enrolled in this quality-improvement project. This study was divided into the pre-intervention phase (1st January, 2012–31st July, 2013) and the intervention phase (1st August, 2013–31st Oct...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Update on fosfomycin-modified genes in Enterobacteriaceae
Publication date: Available online 21 November 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Tsung-Ying Yang, Po-Liang Lu, Sung-Pin TsengAbstractThe long-used antibiotic fosfomycin has recently been re-evaluated as a potential regimen for treating extended-spectrum β-lactamases (ESBLs) and carbapenem-resistant Enterobacteriaceae (CRE). Fosfomycin is known for its robust bactericidal effect against ESBL-producing Enterobacteriaceae and CRE. However, fosfomycin-modified genes have been reported in transposon elements and conjugative plasmids, resulting in fosfomycin resistance in parts of East ...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Metabolic reprogramming of hydrogenosomal amino acids in Trichomonas vaginalis under glucose restriction
Publication date: Available online 21 November 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Kuo-Yang Huang, Seow-Chin Ong, Chih-Ching Wu, Chia-Wei Hsu, Hsin-Chung Lin, Yi-Kai Fang, Wei-Hung Cheng, Po-Jung Huang, Cheng-Hsun Chiu, Petrus TangAbstractBackgroundGlucose is the major energy source that is converted to pyruvate for ATP generation in the trichomonad hydrogenosome. Under glucose restriction (GR), the regulation of amino acids metabolism is crucial for trichomonad growth and survival. RNA-sequencing (RNA-seq) analysis has been used to identify differentially expressed genes in Trichomonas ...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Influenza virus infections from 0 to 2 years of age: A birth cohort study
ConclusionThe yearly incidence of seasonal influenza was 5% in this cohort of very young children with variable influenza vaccine coverage. Adjuvanted vaccine against the pandemic influenza was highly effective. Both seasonal and pandemic influenza cases were mostly non-severe. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Genetic analysis of virulence and antimicrobial-resistant plasmid pOU7519 in Salmonella enterica serovar Choleraesuis
ConclusionThe deletion of both the int and att sties could likely block chimera excision, and result in an irreversible, stable pSCV50-pSC138 chimera. The emergence of conjugative virulence and antimicrobial-resistant plasmids in S. Choleraesuis could pose a threat to health public. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Role of tubulointerstitial lesions in predicting renal outcome among pediatric onset lupus nephritis – A retrospective cohort study
ConclusionTubulointerstitial abnormalities were found in nearly one-third of all pediatric LN cases. With its importance in early identifying those at risk of renal failure, histologic classification considering tubulointerstitial lesions may potentially assist outcome prediction. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Capnocytophaga sputigena pneumonia and bacteremia in a patient with diabetes and gastric cancer
Publication date: Available online 19 December 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Shih-Hao Lo, Yung-Yun Chang, Ya-Ting Jao, Wen-Hung Wang, Po-Liang Lu, Yen-Hsu Chen (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Community-acquired bacteremic pneumonia due to Pasteurella multocida subspecies multocida in a patient with poor-control diabetes mellitus
Publication date: Available online 19 December 2017Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Wen-Sen Lee, Fu-Lun Chen, Cheng-Hui Wang, Tsong-Yih Ou, Yi-Hsuan Lin, Shio-Shin Jean (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Identification of a proteomic biomarker associated with invasive ST1, serotype VI Group B Streptococcus by MALDI-TOF MS
ConclusionsThe protein peak of 6251 Da may play a role of emergence of ST-1 clone, serotype VI GBS in central Taiwan and could be useful in rapid identifying invasive serotype VI from III isolates, which is hardly achieved by LA. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Updates on the molecular epidemiology of Enterovirus D68 after installation of screening test among acute flaccid paralysis patients in Taiwan
This article updated the molecular epidemiology trends of EV-D68 from the national surveillance data. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Endophthalmitis caused by Purpureocillium lilacinum
Publication date: Available online 20 January 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Li-Na Guo, He Wang, Po-Ren Hsueh, Jacques F. Meis, Huan Chen, Ying-Chun Xu (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Clinical characteristics and treatment outcomes of pulmonary invasive fungal infection among adult patients with hematological malignancy in a medical centre in Taiwan, 2008–2013
This study was aimed to investigate clinical characteristics and treatment outcomes of pulmonary invasive fungal infection (IFI) among patients with hematological malignancy.MethodsAll patients with hematological malignancy who were treated at a medical centre from 2008 to 2013 were evaluated. Pulmonary IFI was classified according to the European Organization for Research and Treatment of Cancer 2008 consensus.ResultsDuring the study period, 236 (11.3%) of 2083 patients with hematological malignancy were diagnosed as pulmonary IFI, including 41 (17.4%) proven, 75 (31.8%) probable, and 120 (50.8%) possible cases. Among the...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

An oil refinery worker at Kaohsiung, with Pseudoxanthomonas kaohsiungensis bloodstream infection presenting as chronic pericarditis and masquerading as tuberculosis pericarditis
Publication date: Available online 31 January 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Shu-Fang Kuo, Chen-Hsiang Lee (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Diabetic patients suffering dengue are at risk for development of dengue shock syndrome/severe dengue: emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity
Publication date: Available online 31 January 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Ing-Kit Lee, Ching-Jung Hsieh, Chien-Te Lee, Jien-Wei LiuAbstractBackground/purposeThe impact of type 2 diabetes mellitus (DM2) on clinical severity of dengue has not been fully understood. We aimed to assess risk factors for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) and severe dengue (SD) (defined based on the World Health Organization 1997 and 2009 dengue classifications), and additionally identify, among DM2 patients, who are at risk for developing DHF/DSS and severe dengue.MethodsA retr...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Genetic diversity of toxigenic Vibrio cholerae O1 from Sabah, Malaysia 2015
ConclusionThis study revealed that V.cholerae in Sabah were genetically diverse and were atypical El Tor strains. Fingerprint patterns of these isolates will be useful in tracing the origin of this pathogen in the future. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Monosodium urate crystals induced ICAM-1 expression and cell–cell adhesion in renal mesangial cells: Implications for the pathogenesis of gouty nephropathy
ConclusionThe MSU induced ICAM-1 expression on HRMCs and cell–cell adhesion involved TLR2/4-p38-ICAM1 pathway and TLR2/4 independent ASC-p38-ICAM1 axis. These findings might partly explain the mechanisms underlying gouty nephropathy. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Breakthrough fungemia caused by Rhodotorula mucilaginosa during anidulafungin therapy
Publication date: Available online 1 February 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Cheng-Hui Wang, Po-Ren Hsueh, Fu-Lun Chen, Wen-Sen LeeAbstractRhodotorula spp. is an emergent opportunistic pathogen, particularly in critically ill and immunocompromised patients. They have been associated with peritonitis, endocarditis, meningitis, and catheterassociated infections.1,2,6 Here, we report a patient with gall bladder stone complicating with obstructive jaundice and acute cholecystitis. He suffered from Candidemia (Candida tropicalis) due to hospital acquired catheter-related infections. He r...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Immunodominance of LipL3293–272 peptides revealed by leptospirosis sera and therapeutic monoclonal antibodies
In this study, recombinant LipL3293–147 and LipL32148–184 middle domain of LipL3293–184, and LipL32171–214, and LipL32215–272 of c-terminal LipL32171–272 truncations were defined for immunodominance of the molecule during Leptospira infections revealed by leptospirosis sera.ResultsIgM-dominant was directed to highly surface accessible LipL32148–184 and Lipl32171–214. IgG dominance of LipL32148–184 revealed by rabbit anti-Leptospira sera and convalescent leptospirosis paired sera were mapped to highly accessible surface of middle LipL32148–184 truncation whereas tw...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Human papillomavirus infection is not associated with laryngeal squamous cell carcinoma in Taiwan
Publication date: Available online 21 February 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chung-Guei Huang, Li-Ang Lee, Tuan-Jen Fang, Hsueh-Yu Li, Chun-Ta Liao, Chung-Jan Kang, Tzu-Chen Yen, Kuo-Chien Tsao, Tse-Ching Chen, Shin-Ru ShihAbstractBackground/PurposeTo examine whether the prevalence rate of human papillomavirus (HPV) infection in Taiwanese patients with primary laryngeal squamous cell carcinoma (LSCC) is different from that in those with a vocal polyp (VP) or vocal fold leukoplakia (VFL).MethodsThis prospective cohort study recruited 41 consecutive patients with primary LSCC and 27 ...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Predominance of methicillin-resistant Staphylococcus aureus in the residents and environments of long-term care facilities in Taiwan
ConclusionsMRSA was the most commonly colonized MDRO, both in the LTCF residents and in the environment, followed by MDRAB and carbapenem-resistant K. pneumoniae. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Utility of a blood culture time to positivity-incorporated scoring model in predicting vascular infections in adults with nontyphoid Salmonella bacteremia
Publication date: Available online 21 February 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Jr-Jiun Lin, Tzu-Hua Weng, Wen-Pin Tseng, Shang-Yu Chen, Chia-Ming Fu, Hui-Wen Lin, Chun-Hsing Liao, Tai-Fen Lee, Po-Ren Hsueh, Shey-Ying ChenAbstractBackgroundVascular infections (VI) are potentially catastrophic complications of nontyphoid Salmonella (NTS). We aimed to develop a scoring model incorporating information from blood culture time to positivity (TTP-NTSVI) and compared the prediction capability for VI among adults with NTS bacteremia between TTP-NTSVI and a previously published score (Chen-NTS...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

A novel pathogenic mutation on Interleukin-7 receptor leading to severe combined immunodeficiency identified with newborn screening and whole exome sequencing
Publication date: Available online 2 March 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Cheng-Yu Liao, Hui-Wen Yu, Chao-Neng Cheng, Jiann-Shiuh Chen, Ching-Wei Lin, Peng-Chieh Chen, Chi-Chang ShiehAbstractBackgroundPatients with severe combined immunodeficiency (SCID), which is caused by genetic defects in immune-related genes involved in the development or activation of the adaptive immune system, often died in infancy due to severe infections before definite molecular diagnosis could be made. Although recent improvement in early diagnosis has been achieved by newborn screening, the genetic basi...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Clinical features of acute human immunodeficiency virus infection in Taiwan: A multicenter study
ConclusionsManifestations of acute HIV infection are nonspecific and of wide spectrum ranging from fever to severe illness. A higher proportion of patients with initial CD4 counts of 200 cells/mm3 or less during acute HIV infection warrants early, timely diagnosis and treatment to prevent rapid disease progression. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Differential expressions of plasma proteins in systemic lupus erythematosus patients identified by proteomic analysis
Publication date: Available online 29 March 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Rashmi Madda, Shih-Chang Lin, Wei- Hsin Sun, Shir-Ly HuangAbstractIntroductionSystemic lupus erythematosus (SLE) is a chronic and complex autoimmune disease with a wide range of clinical manifestations that affects multiple organs and tissues. Therefore the differential expression of proteins in the serum/plasma have potential clinical applications when treating SLE.MethodsWe have compared the plasma/serum protein expression patterns of nineteen active SLE patients with those of twelve age-matched and gender-...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Updates on k13 mutant alleles for artemisinin resistance in Plasmodium falciparum
ConclusionAccording to the updates in the review, it can be concluded artemisinin resistance does not disseminate to India and African countries within short period whereas regular tracking of these mutants is necessary. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Clinical characteristics, treatments, and outcomes of hematogenous pyogenic vertebral osteomyelitis, 12-year experience from a tertiary hospital in central Taiwan
ConclusionIn Taiwan, HPVO mainly affected the elderly and S. aureus remained the most common HPVO pathogen. In patients with risk factors associated with HPVO recurrence, a longer duration (≥6 weeks) of antimicrobial therapy is suggested. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Subgingival microbiota in individuals with severe chronic periodontitis
ConclusionThis study is the first in Taiwan to provide a picture of the microbiome in SP via 16S rRNA metagenomics. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Prevalence of cervical colonization by Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis and Mycoplasma genitalium in childbearing age women by a commercially available multiplex real-time PCR: An Italian observational multicentre study
Conclusionmultiplex RT-PCR can be a valuable tool to evaluate the real epidemiology of cervical mycoplasma colonization. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Laboratory investigation of a suspected outbreak caused by Providencia stuartii with intermediate resistance to imipenem at a long-term care facility
ConclusionsIsolates of similar pulsotypes could appear after 15 months and caused urosepsis in another resident of the same LTCF. The bacterium may have persisted in the environment and caused opportunistic infection. As LTCF residents are usually vulnerable to infections, surveillance of multidrug-resistant organisms and infection control intervention that have been established in acute-care hospitals to control infections by resistant organisms are apparently as essential in LTCFs. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

The impact of inoculum size on the activity of cefoperazone-sulbactam against multidrug resistant organisms
This study aims to assess the in vitro activity of cefoperazone alone and different cefoperazone-sulbactam ratios against different inoculum sizes of multidrug resistant organisms.MethodsMinimum inhibitory concentrations (MICs) of cefoperazone, cefoperazone-sulbactam at fixed ratio of 1:1 and 2:1 against a normal inoculum size of 5 × 105 CFU/ml and a high inoculum size of 5 × 107 CFU/ml were measured.ResultsEach 33 isolates of extended-spectrum β-lactamases (ESBL)-producing Escherichia coli, ESBL-producing Klebsiella pneumoniae, carbapenem-resistant E. coli, and carbapene...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Invasive pneumococcal pneumonia caused by 13-valent pneumococcal conjugate vaccine types in children with different schedules
This study was conducted to identify risk factors and different 13-valent pneumococcal conjugate vaccine (PCV13) schedules associated with vaccine-type invasive pneumococcal pneumonia (IPP) despite prior vaccination.MethodsA case–control study was conducted prospectively between August 2012 and December 2015 at five participating medical centers. The study enrolled children
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Thermostabilization of indigenous multiplex polymerase chain reaction reagents for detection of enterotoxigenic Staphylococcus aureus
ConclusionThe sensitive, cost-effective, ready-to-use, and ambient temperature stable formulation could be implemented as a detection tool in food analysis and diagnostic laboratories and hospitals and for on-field application outside the laboratories, as well as for detection of toxigenic strains of S. aureus. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research

Characteristics of children with Kawasaki disease requiring intensive care: 10 years' experience at a tertiary pediatric hospital
Publication date: April 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 2Author(s): Ching-Chia Kuo, Yu-Shin Lee, Ming-Ru Lin, Shao-Hsuan Hsia, Chih-Jung Chen, Cheng-Hsun Chiu, Mao-Sheng Hwang, Yhu-Chering HuangAbstractBackground/PurposeKawasaki disease (KD) is a febrile systemic vasculitis, and some patients may develop serious complications requiring intensive care. We aim to ascertain the clinical presentations and outcomes of these patients.MethodsFrom October 2004 to October 2014, children with KD who had stayed in the pediatric intensive care unit (ICU) for acute stage treatment were de...
Source: Journal of Microbiology, Immunology and Infection - July 10, 2018 Category: Microbiology Source Type: research