Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection
Publication date: Available online 21 February 2019Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Peiju Tsai, Tze-Yu Lin, Shiang-Lin Cheng, Hung-Yu Sun, Sung-Fang Chen, Kung-Chia Young (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 22, 2019 Category: Microbiology Source Type: research

The new perspective of old antibiotic:In vitro antibacterial activity of TMP-SMZ against Klebsiella pneumoniae
ConclusionThese results provided insights into the antimicrobial efficacy of TMP-SMZ against K. pneumoniae, also illustrating the wide distribution of SMZ and TMP resistance genes among resistant K. pneumoniae. Simultaneously, the present study highlights the significance of reasonable administration and effective continued monitoring. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 20, 2019 Category: Microbiology Source Type: research

Influenza vaccination and risk of respiratory failure in patients with chronic obstructive pulmonary disease: A nationwide population-based case-cohort study
Publication date: February 2019Source: Journal of Microbiology, Immunology and Infection, Volume 52, Issue 1Author(s): Hsin-Hui Huang, Su-Jung Chen, Tze-Fan Chao, Chia-Jen Liu, Tzeng-Ji Chen, Pesus Chou, Fu-Der WangAbstractBackgroundChronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease which causes a considerable disease burden. Patients with COPD are at a higher risk for influenza infection and influenza vaccination are recommended at this high risk patient group. In the current study, we aimed to evaluate the association between influenza vaccination and the risk of respiratory failure (RF) in CO...
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Hypermucoviscosity, rmpA, and aerobactin are associated with community-acquired Klebsiella pneumoniae bacteremic isolates causing liver abscess in Singapore
Publication date: February 2019Source: Journal of Microbiology, Immunology and Infection, Volume 52, Issue 1Author(s): Thean Yen Tan, Melissa Ong, Yvonne Cheng, Lily Siew Yong NgAbstractIntroductionThis retrospective study investigated the clinical etiology of community-acquired bacteremic Klebsiella pneumoniae infections, and characterized laboratory and genetic markers which may be associated with primary liver abscess (PLA).MethodsCommunity-onset K. pneumoniae bacteremic episodes from 2010 to 2011 were identified from the laboratory information system. Isolates were retrieved for susceptibility testing, hypermucoviscosi...
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Safety and efficacy of oral nemonoxacin versus levofloxacin in treatment of community-acquired pneumonia: A phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority trial
ConclusionNemonoxacin 500 mg once daily for 7–10 days is as effective and safe as levofloxacin for treating adult CAP patients in terms of clinical cure rates, microbiological success rates, and safety profile.ClinicalTrials.gov identifier: NCT01529476. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Prevalence of and risk factors for nasal methicillin-resistant Staphylococcus aureus colonization among children in central Taiwan
ConclusionAn increasing trend of MRSA nasal carriage rate in Taiwan had been brought forward, however, it was not observed in central Taiwan during the period of 2005–2010. We found a summer peak on both MRSA and MSSA carriages. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Characteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity
ConclusionThe elderly cases with scrub typhus, murine typhus, or acute Q fever would be more likely to have severe complications, for which prothrombin time prolongation is an important predictor for severe complications. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Epidemiology and antimicrobial susceptibility of non-typeable Haemophilus influenzae in otitis media in Taiwanese children
Publication date: February 2019Source: Journal of Microbiology, Immunology and Infection, Volume 52, Issue 1Author(s): Ying-Chun Cho, Nan-Chang Chiu, Fu-Yuan Huang, Daniel Tsung-Ning Huang, Lung Chang, Ching-Ying Huang, Yen-Hsin Kung, Kuo-Sheng Lee, Hsin ChiAbstractBackgroundConcerns about non-typeable Haemophilus influenzae (NTHi) in otitis media (OM) have grown after the introduction of pneumococcal conjugate vaccine (PCV). We aim to better understand the clinical role of NTHi in pediatric OM.MethodsMiddle ear fluid samples from children
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Deep sequencing profiles MicroRNAs related to Aspergillus fumigatus infection in lung tissues of mice
ConclusionWe conclude that deep-sequencing small RNAs can uncover miRNA pool-regulating IPA. Our results may lead to further understanding IPA pathogenesis and gain insight into the complexity and diversity of small RNA molecules that regulate immunodeficient IPA. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Treatment of larva migrans syndrome with long-term administration of albendazole
ConclusionsThe long-term administration treatment of albendazole is safe and effective for larva migrans syndrome. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria
Publication date: February 2019Source: Journal of Microbiology, Immunology and Infection, Volume 52, Issue 1Author(s): Vincent P. Gyang, Ting-Wu Chuang, Chien-Wei Liao, Yueh-Lun Lee, Olaoluwa P. Akinwale, Akwaowo Orok, Olusola Ajibaye, Ajayi J. Babasola, Po-Ching Cheng, Chia-Mei Chou, Ying-Chieh Huang, Pasaiko Sonko, Chia-Kwung FanAbstractBackground/purposeIntestinal parasitic infections (IPIs) among school aged children (SAC) in Nigeria remains endemic, hence the need for regular surveillance to attract the attention of policy makers. This cross-sectional study investigated the current prevalence and factors associated wi...
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Clinical and microbiological characteristics of patients with bacteremia caused by Campylobacter species with an emphasis on the subspecies of C. fetus
ConclusionDatabase expansion of MALDI-TOF MS for the correct identification of C. fetus to subspecies levels is needed. A novel clone of ST57-PFGE Cluster C of C. fetus subsp. venerealis was noted. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

The influence of breastfeeding in breast-fed infants with atopic dermatitis
Publication date: February 2019Source: Journal of Microbiology, Immunology and Infection, Volume 52, Issue 1Author(s): Hao-Pai Lin, Bor-Luen Chiang, Hsin-Hui Yu, Jyh-Hong Lee, Yu-Tsan Lin, Yao-Hsu Yang, Li-Chieh WangAbstractBackgroundThe aim of this study was to evaluate whether breastfeeding should be discontinued for exclusively breast-fed infants with atopic dermatitis (AD).MethodsEighty-seven exclusively breast-fed infants with AD were enrolled in a prospective observational study. The infants were divided into 3 groups: breastfeeding only (BM group), partial breastfeeding and partial partially hydrolyzed whey formula ...
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Safety and effectiveness of tocilizumab in treating patients with rheumatoid arthritis – A three-year study in Taiwan
ConclusionIn this 3-year real-world study on RA patients of Taiwan, we found a good long-term effectiveness and similar safety profiles for the TCZ treatment. With prophylactic strategy for latent TB and pre-emptive antiviral treatment for HBV carriers, the risk of reactivation of latent TB and HBV may be reassured. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Semaphorin 3A in Ankylosing Spondylitis
ConclusionSerum Sema 3A level was increased in AS patients and was inversely correlated to Schöber's test. Serum Sema 3A is better as a bio-marker than ESR or CRP to correlate with high disease activity in AS patients, and it is also a good indicator for monitoring disease activity and functional status during anti-TNF treatment. Also, Sema 3A may be taken as a predictor for extra-articular presentations in AS, but this needs further study to elucidate. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 15, 2019 Category: Microbiology Source Type: research

Molecular characterization of vancomycin-resistant enterococci isolated from a hospital in Beijing, China
ConclusionThis study confirms that VREfm isolates associated with ST78 were the main epidemic lineage responsible for nosocomial infections in China, as were also observed in other nations worldwide. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - February 12, 2019 Category: Microbiology Source Type: research

Identification of a novel protein in the genome sequences of Leptospira interrogans with the ability to interact with host’s components
ConclusionsThis novel leptospiral protein may function as an adhesin at the colonization steps and may help the invasion process by plasmin generation at the bacterial cell surface. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 22, 2019 Category: Microbiology Source Type: research

Distribution of virulence genes in bacteremic methicillin-resistant Staphylococcus aureus isolates from various sources
ConclusionsA major MRSA lineage, CC8-ST239-MRSA-SCCmec type III-spa type t037, is noted among bacteremic MRSA isolates. No disease-specific virulent genes can be identified. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 11, 2019 Category: Microbiology Source Type: research

Synergistic effect of linezolid with fosfomycin against Staphylococcus aureus in vitro and in an experimental Galleria mellonella model
ConclusionThis work indicated that linezolid combination with fosfomycin has synergistic effect against S. aureus in vitro and in an experimental G. mellonella model, and it suggests that high-dose of linezolid and fosfomycin may not necessary. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 10, 2019 Category: Microbiology Source Type: research

Microbiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: a ten-year single-center study in Taiwan
Publication date: Available online 8 January 2019Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Hsin-Hui Wang, Chung-Hao Huang, Mei-Chuan Kuo, Shang-Yi Lin, Chin-Huei Hsu, Chun-Yuan Lee, Yi-Wen Chiu, Yen-Hsu Chen, Po-Liang LuaAbstractBackgroundPeritoneal dialysis (PD)-related infection is a serious complication of patients with PD. Refractory peritonitis may lead to failure of PD, shift to hemodialysis (HD) or death. Besides, microbiologic resistance increased worldwide that might impact the treatment choice for such infections. Investigating the causative pathogens and risk factors of PD-related infec...
Source: Journal of Microbiology, Immunology and Infection - January 9, 2019 Category: Microbiology Source Type: research

Postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis: clinical analysis of 12 clustered adults and a proposed therapeutic algorithm
Publication date: Available online 6 January 2019Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Jia-Horung Hung, Wen-Chien Ko, Chau-Yin Chen, Sheng-Hsiang Lin, Cheng-Lin Wu, Sheng-Min Hsu, Yu-Ti Teng, Shih-Hao Wang, Sung-Huei Tseng, Fu-Chin Huang, Chun-Chieh Lai, Ching-Lung Chen, Chien-Hsiung Lai, Po-Lin Chen, Evelyn Jou-Chen HuangAbstractPurposePostoperative endophthalmitis caused by nontuberculous mycobacterium is a rare but devastating complication after intraocular surgery. However, optimal treatment strategies remain undetermined in view of its rarity.MethodsWe investigated the cases of culture-pr...
Source: Journal of Microbiology, Immunology and Infection - January 6, 2019 Category: Microbiology Source Type: research

Roles of Toll-Like Receptor 4 for Cellular Pathogenesis in Primary Open-Angle Glaucoma: A potential therapeutic strategy
Publication date: Available online 27 December 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Teera PoyomtipAbstractIn recent years, glaucoma has been proposed as an autoimmune disease and an understanding immune-regulation concept has been applied for novel glaucoma therapy. Current evidence suggests an innate immunity is a keystone step for primary open angle glaucoma (POAG) pathogenesis resulting from trabecular meshwork (TM) cell fibrosis and retinal ganglion cell (RGC) death. Toll-like receptor 4 (TLR4) is a common player in the innate immunity, which appears on the TM and RGC of POAG. The act...
Source: Journal of Microbiology, Immunology and Infection - January 4, 2019 Category: Microbiology Source Type: research

Long-term outcomes in lupus patients receiving different renal replacement therapy
ConclusionThe patients with ESRD caused by lupus nephritis who underwent KT had better long-term outcomes and survival rates than those who received HD or PD. This implies that KT is the better choice of renal replacement therapy in the patients with ESRD caused by lupus nephritis. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 4, 2019 Category: Microbiology Source Type: research

Evaluation of VITEK MS, Clin-ToF-II MS, Autof MS 1000 and VITEK 2 ANC card for identification of Bacteroides fragilis group isolates and antimicrobial susceptibilities of these isolates in a Chinese university hospital
ConclusionAll the four systems provided high accurate rate on the identification of B. fragilis group isolates. Metronidazole showed highest activity against these isolates. Attention should be paid to the higher resistant rates to carbapenems, clindamycin, moxifloxacin and tigecycline than the other countries. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 4, 2019 Category: Microbiology Source Type: research

Synergistic effect of linezolid with fosfomycin against Staphylococcus aureus in vitro and in an experimental Galleria mellonella model
ConclusionThis work indicated that linezolid combination with fosfomycin has synergistic effect against Staphylococcus aureus in vitro and in an experimental Galleria mellonella model, and it suggests that high-dose of linezolid and fosfomycin may not necessary. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 1, 2019 Category: Microbiology Source Type: research

Nut sensitization profile in Southern Taiwan
Publication date: Available online 27 December 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chih-Wei Cheng, Yung-Chih Lin, Bao-Ren Nong, Po-Yen Liu, Yung-Feng Huang, Ling-Ying Lu, Herng-Sheng LeeAbstractBackground/purposeTo evaluate the relationship between serum-specific immunoglobulin E (IgE) to peanuts/tree nuts and their clinical manifestations in atopic diseases.MethodSerum from people with the classical symptoms of asthma, allergic rhinitis (AR), or atopic dermatitis (AD) was collected for the measurement of serum-specific IgE to peanuts, cashew nuts, Brazil nuts, almonds, and coconuts. Cas...
Source: Journal of Microbiology, Immunology and Infection - December 28, 2018 Category: Microbiology Source Type: research

Role of Toll-Like Receptor 4 for cellular pathogenesis in Open-Angle Glaucoma: A Potential Therapeutic Strategy
Publication date: Available online 27 December 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Teera PoyomtipAbstractIn recent years, glaucoma has been proposed as an autoimmune disease and an understanding immune-regulation concept has been applied for novel glaucoma therapy. Current evidence suggests an innate immunity is a keystone step for primary open angle glaucoma (POAG) pathogenesis resulting from trabecular meshwork (TM) cell fibrosis and retinal ganglion cell (RGC) death. Toll-like receptor 4 (TLR4) is a common player in the innate immunity, which appears on the TM and RGC of POAG. The act...
Source: Journal of Microbiology, Immunology and Infection - December 28, 2018 Category: Microbiology Source Type: research

Integrated Safety Summary of Phase II and III Studies Comparing Oral Nemonoxacin and Levofloxacin in Community-Acquired Pneumonia
ConclusionNemonoxacin was well tolerated and no clinically significant safety concerns were identified, suggesting that it possesses a desirable safety and tolerability profile similar to that of levofloxacin, and may be a suitable alternative to fluoroquinolones for treating patients with CAP. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 21, 2018 Category: Microbiology Source Type: research

Deep sequencing reveals multiclonality and new discrete typing units of Trypanosoma cruzi in rodents from the southern United States
ConclusionOur results affirm that mammalian hosts can concurrently harbor a diverse complement of parasites, and indicate that there is greater diversity of T. cruzi DTUs present in North America than previously thought. Further investigation is warranted to understand the role of commensal rodents as a reservoir for T. cruzi in sylvatic and peridomestic environments. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 21, 2018 Category: Microbiology Source Type: research

The Role of 5-Methoxytryptophan in Pediatric-Onset Lupus Nephritis: A Retrospective Cohort Study
ConclusionWe demonstrated that serum 5-MTP level is positively correlated to the disease activity, prognosis, and remission status of pediatric LN in vivo. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 19, 2018 Category: Microbiology Source Type: research

The Clinical Features and Mortality Risk Factors of Cytomegalovirus Infection in Patients with Systemic Lupus Erythematosus
Publication date: Available online 16 December 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): MingLi Hung, Deh-Feng Huang, Wei-Sheng Chen, Chien-Chi Lai, Ming-Han Chen, Hsien-Tzung Liao, Chang-Youh TsaiBackgroundThe clinical features and outcomes of cytomegalovirus (CMV) diseases in patients with systemic lupus erythematosus (SLE) are unknown. We analyzed such data from a medical center in Taiwan.MethodsWe retrospectively reviewed the medical records of patients with SLE who were diagnosed with CMV diseases between 2006 and 2016 in Taipei Veterans General Hospital Taiwan. Clinical and laboratory pa...
Source: Journal of Microbiology, Immunology and Infection - December 16, 2018 Category: Microbiology Source Type: research

High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan
Publication date: Available online 15 December 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Yu-Tsun Su, Yen-Ting Lin, Ching-Chi Yang, Shang-Shyue Tsai, Jiu-Yao Wang, Ya-Ling Huang, Ting-I. Lin, Tsun-Mei Lin, Yu-Cheng Tsai, Hong-Ren Yu, Ching-Chung Tsai, Ming-Chun YangAbstractBackground/PurposesHuman rhinovirus type C (HRV-C) has been associated with asthma exacerbation (AE) in children in several countries. However, in Taiwan the association between HRV, especially HRV-C, and AE in children has yet to be elucidated. We sought to investigate the prevalence of respiratory viruses in children with a...
Source: Journal of Microbiology, Immunology and Infection - December 15, 2018 Category: Microbiology Source Type: research

Immune response to asymptomatic infections by Entamoeba histolytica and other enteric pathogens in pregnant women and their infants in a high HIV burdened setting in Zimbabwe
Publication date: Available online 7 December 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Agness Farai Nhidza, Thajasvarie Naicker, Babill Stray-Pedersen, Tawanda Jonathan Chisango, Edson Panganayi Sibanda, Aziah Ismail, Tsitsi Bandason, Curtis Makaza, Kerina Duri, Takafira MduluzaAbstractBackgroundAsymptomatic Entamoeba histolytica infections in pregnant women puts infants at risk of infection through vertical transmission or transmission during breastfeeding in high HIV prevalence areas. The study aimed at investigating the immune response to asymptomatic Entamoeba histolytica infection in pre...
Source: Journal of Microbiology, Immunology and Infection - December 8, 2018 Category: Microbiology Source Type: research

Recommendations and Guidelines for the Treatment of Pneumonia in Taiwan
Publication date: Available online 6 December 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chih-Chen Chou, Ching-Fen Shen, Su-Jung Chen, Hsien-Meng Chen, Yung-Chih Wang, Wei-Shuo Chang, Ya-Ting Chang, Wei-Yu Chen, Ching-Ying Huang, Ching-Chia Kuo, Ming-Chi Li, Jung-Fu Lin, Shih-Ping Lin, Shih-Wen Ting, Tzu-Chieh Weng, Ping-Sheng Wu, Un-In Wu, Pei-Chin Lin, Susan Shin-Jung Lee, Yao-Shen ChenSummaryPneumonia is a leading cause of death worldwide, ranking third both globally and in Taiwan. This guideline was prepared by the 2017 Guidelines Recommendations for Evidence-based Antimicrobial agents use ...
Source: Journal of Microbiology, Immunology and Infection - December 7, 2018 Category: Microbiology Source Type: research

Immune response to purified protein derivative in infants from helminth-sensitized mothers — A cases series
ConclusionInfants with Th1 and Th2 profile chemokines demonstrated a good response to vaccination, indicated by CXCL10 levels, but not infants predominantly Th2-skewed profile. These results highlight that children from mothers sensitized to S. mansoni may lead to ineffective immune response to PPD, while mothers sensitized to Ascaris lumbricoides showed no such impairment. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 4, 2018 Category: Microbiology Source Type: research

Clinical outcomes and prognostic factors of patients with severe influenza receiving intravenous peramivir salvage therapy in intensive care units
ConclusionAs a salvage therapy, intravenous peramivir provided a survival rate of 62% and was well tolerated in patients with severe influenza. The initiation of effective antiviral treatment as early as possible within 48 h is recommended for hospitalized patients. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Extended-spectrum β-lactamase-producing Escherichia coli bacteremia: Comparison of pediatric and adult populations
This study investigated the clinical features and bacteriology of pediatric patients with ESBL-producing E. coli bacteremia and compared their characteristics with those of adult patients.MethodsClinical and laboratory data from all of the 41 patients aged ≤18 years diagnosed with E. coli bacteremia were collected over 5 years. Patients aged>18 years diagnosed with E. coli bacteremia, matched 1:1 for calendar time, were enrolled as the adult group. All E. coli isolates were tested for their blaCTX-M group and sequence type 131 (ST131). A novel seven-single nucleotide polymorphism-based clonotyping test was applied to...
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Immunogenicity and protective efficacy of a newly developed tri-component diphtheria, tetanus, and acellular pertussis vaccine in a murine model
ConclusionThe results showed inferior immunogenicity of the new DTaP vaccine compared to a commercial vaccine despite comparable cellular immunity and protective efficacy. Some efforts are necessary for improving immunogenicity against filamentous hemagglutinin and pertactin before conducting human clinical trials. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: Emphasizing risk of severe dengue in the elderly
ConclusionsElderly had lower frequency of classical dengue symptoms, yet were at higher risk of development of severe dengue during their early dengue course. A small number of patients developed severe dengue at the WHO-proposed recovery phase. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Clinical and epidemiological characteristics of human parainfluenza virus infections of children in southern Taiwan
ConclusionThe impact caused by HPIVs infections is significant in hospitalized children. In the current study, our results contribute to the epidemiologic, clinical and laboratory information of HPIV infection in children in the important areas of respiratory tract infection that could support the development of optimization management. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Nasal methicillin-resistant Staphylococcus aureus colonization among otherwise healthy children aged between 2 months and 5 years in northern Taiwan, 2005–2010
ConclusionBetween 2005 and 2010, 10.2% of healthy children in northern Taiwan carried MRSA in anterior nares, with the highest carriage rate for infants aged 2–6 months. Two emerging clones, ST 508 and ST 573, were identified and the clinical significance needs further surveillance. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Predictors of polymyxin B treatment failure in Gram-negative healthcare-associated infections among critically ill patients
ConclusionsTo the best of our knowledge, this is the first report on the association of inadequate dose of polymyxin B (
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Desiccation and ethanol resistances of multidrug resistant Acinetobacter baumannii embedded in biofilm: The favorable antiseptic efficacy of combination chlorhexidine gluconate and ethanol
This study aimed to investigate the correlation between the biofilm formation and survival of MDRABs, and to investigate the antiseptic efficacy of hand sanitizers for the MDRABs, embedded with biofilm (MDRAB-Bs).MethodsThe MDRABs were selected randomly after pulsed-field gel electrophoresis (PFGE), and their biofilm formation was analyzed. Desiccation and ethanol tolerances were assayed to test the bacterial survival. The antiseptic efficacy of combined chlorhexidine gluconate (CHG) and 70% ethanol agents against MDRAB-Bs were compared with the 70% ethanol cleanser.ResultsEleven MDRABs, which varied in biofilm formation (...
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Ureaplasma spp. in male infertility and its relationship with semen quality and seminal plasma components
Publication date: December 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 6Author(s): Yun Heng Zhou, Hong Xia Ma, Xiao Xing Shi, Yang LiuAbstractObjectiveWe investigated the prevalence of Ureaplasma spp. in semen samples of infertile men in Shanghai, China and evaluated the correlation between the sperm parameters (seminal volume, sperm concentration, progressive motility and non-progressive) and the secretary function in these infectious populations.MethodsSemens were collected from 540 infertile men and 260 fertile control group in shanghai, China and subjected to standard bacterial and U...
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Efficacy of isoniazid salvage therapy for latent tuberculosis infection in patients with immune-mediated inflammatory disorders – A retrospective cohort study in Taiwan
Publication date: December 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 6Author(s): Shiang-Fen Huang, Ming-Han Chen, Fu-Der Wang, Chang-Youh Tsai, Chang-Phone Fung, Wei-Juin SuAbstractBackgroundActive tuberculosis (TB) in patients with latent tuberculosis infection (LTBI) was associated with use of biological agents for immune-mediated inflammatory disorders (IMIDs). For decreasing active TB, isoniazid prophylaxis therapy was administered before biologic therapy among IMID patients with LTBI. However, for patients who had been received biologics for a long time with unknown status of LTBI...
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Investigation of a nosocomial outbreak of fungemia caused by Candida pelliculosa (Pichia anomala) in a Korean tertiary care center
ConclusionsThis is the first report of a nosocomial outbreak involving 11 patients in 2 ICUs and 2 general wards caused by C. pelliculosa in South Korea. Infection control measures are important for decreasing transmission of C. pelliculosa in the hospital. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Clinical characteristics, radiologic findings, risk factors and outcomes of serum galactomannan-negative invasive pulmonary aspergillosis
ConclusionNeutropenia and prior receipt of mold-active antifungal drugs before GM assay were independently associated with GM positivity among patients with proven/probable IPA. Angioinvasive aspergillosis was less common in GM-negative IPA than in GM-positive IPA. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Low-dose trimethoprim-sulfamethoxazole treatment for pneumocystis pneumonia in non-human immunodeficiency virus-infected immunocompromised patients: A single-center retrospective observational cohort study
ConclusionLow-dose TMP-SMX may be a treatment option for patients with non-HIV PCP. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Bloodstream infections in hospitalized adults with dengue fever: clinical characteristics and recommended empirical therapy
ConclusionsBSI pathogens vary among dengue patients. For adults with dengue and suspected BSI hospitalized within one week, empirical antimicrobial agents are recommended. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 23, 2018 Category: Microbiology Source Type: research

Potential role of autophagy in proteolysis in Trichomonas vaginalis
ConclusionOur findings unveiled previously unidentified functions of autophagy in proteostasis in trichomonads, advancing our understanding of this highly conserved process in the ancient eukaryote. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 22, 2018 Category: Microbiology Source Type: research