T-SPOT ®.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers.
T-SPOT®.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers. J Microbiol Immunol Infect. 2019 Jun 05;: Authors: Aksornchindarat W, Yodpinij N, Phetsuksiri B, Srisungngam S, Rudeeaneksin J, Bunchoo S, Klayut W, Sangkitporn S, Khawcharoenporn T Abstract BACKGROUND: Screening for latent tuberculosis infection (LTBI) is important to identify healthcare workers (HCWs) benefiting from preventive therapy. Interferon-gamma release assays (IGRAs) are sensitive and specific tests for LTBI diagnosis. However, in settings where IGRAs are not available...
Source: Journal of Microbiology, Immunology, and Infection - June 5, 2019 Category: Microbiology Authors: Aksornchindarat W, Yodpinij N, Phetsuksiri B, Srisungngam S, Rudeeaneksin J, Bunchoo S, Klayut W, Sangkitporn S, Khawcharoenporn T Tags: J Microbiol Immunol Infect Source Type: research

Role of SOCS3 in enhanced acute-phase protein genes by neonatal macrophages in response to IL-6.
CONCLUSION: Neonatal exhibit an enhanced expression of downstream target genes and IL-6/STAT3 signal pathway which is related with the diminished SOCS3. This provides a new sight into inflammatory responses in neonatal. PMID: 31204209 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 1, 2019 Category: Microbiology Authors: Chen XF, Wu J, Zhang YD, Zhang CX, Chen XT, Zhao W, Chen TX Tags: J Microbiol Immunol Infect Source Type: research

Corrigendum to "The clinical features and mortality risk factors of cytomegalovirus infection in patients with systemic lupus erythematosus" [J Microbiol Immunol Infect 52/1 (2019) 114-121].
Corrigendum to "The clinical features and mortality risk factors of cytomegalovirus infection in patients with systemic lupus erythematosus" [J Microbiol Immunol Infect 52/1 (2019) 114-121]. J Microbiol Immunol Infect. 2019 May 27;: Authors: Hung ML, Huang DF, Chen WS, Lai CC, Chen MH, Liao HT, Tsai CY PMID: 31147245 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 27, 2019 Category: Microbiology Authors: Hung ML, Huang DF, Chen WS, Lai CC, Chen MH, Liao HT, Tsai CY Tags: J Microbiol Immunol Infect Source Type: research

Early-onset eczema is associated with increased milk sensitization and risk of rhinitis and asthma in early childhood.
Abstract BACKGROUND: Atopic eczema and food allergy most commonly occur in the early childhood. However, the relationships between eczema onset and their relevance to the occurrence of atopic diseases relating to allergen sensitization remain unclear. METHODS: We investigated 186 children who were followed up regularly at the clinic for 4 years in a birth cohort study. The children were classified into three groups: early-onset eczema (
Source: Journal of Microbiology, Immunology, and Infection - May 8, 2019 Category: Microbiology Authors: Chiu CY, Yang CH, Su KW, Tsai MH, Hua MC, Liao SL, Lai SH, Chen LC, Yeh KW, Huang JL Tags: J Microbiol Immunol Infect Source Type: research

Impact of initiation of combination antiretroviral therapy according to the WHO recommendations on the survival of HIV-positive patients in Taiwan.
CONCLUSIONS: While continued efforts are needed to improve early diagnosis and linkage to care, initiation of cART improved survival among HIV-positive patients in Taiwan according to the increasing CD4 cut-off values that were recommended by the WHO. PMID: 31105037 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 7, 2019 Category: Microbiology Authors: Liu WD, Tsai WC, Hsu WT, Shih MC, Chen MY, Sun HY, Hsieh SM, Sheng WH, Chuang YC, Cheng A, Lin KY, Huang YS, Huang SH, Huang YC, Chen GJ, Wu PY, Hung CC, Chang SC Tags: J Microbiol Immunol Infect Source Type: research

The clinical implication of serotype distribution and drug resistance of invasive pneumococcal disease in children: A single center study in southern Taiwan during 2010-2016.
Abstract BACKGROUND: The regional study of pediatric invasive pneumococcal disease (IPD) is still limited in Taiwan. The aim of this study is to update the epidemiologic data of pediatric IPD in Taiwan, focusing on the trend of non-13-valent pneumococcal conjugate vaccines (PCV13)-specific serotypes and antimicrobial susceptibility. METHODS: This was a single-center retrospective study by chart reviewing and recruited patients aged
Source: Journal of Microbiology, Immunology, and Infection - May 7, 2019 Category: Microbiology Authors: Lee MC, Kuo KC Tags: J Microbiol Immunol Infect Source Type: research

Usefulness of the FilmArray meningitis/encephalitis (M/E) panel for the diagnosis of infectious meningitis and encephalitis in Taiwan.
CONCLUSIONS: The BioFire® ME Panel performed equivalently to the traditional PCR methods for virus detection, and better than bacterial cultures. This revolutionary system represents a paradigm shift in the diagnosis of M/E and may aid in the rapid identification of community-acquired M/E. However, the usefulness of this tool is limited in regions with a high prevalence of infectious M/E caused by microorganisms not included in the panel. PMID: 31085115 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 30, 2019 Category: Microbiology Authors: Lee SH, Chen SY, Chien JY, Lee TF, Chen JM, Hsueh PR Tags: J Microbiol Immunol Infect Source Type: research

Clinicoepidemiologic characteristics of scrub typhus and murine typhus: A multi-center study in southern Taiwan.
CONCLUSION: In the present study, island area exposure, arthropod bite, eschar, and lymphadenopathy were unique manifestations of ST. Mountainous area exposure is a predictive factor for ST, while contact with rats predicted MT. There was no difference in defervescence time between these two rickettsioses after doxycycline treatment. PMID: 31088776 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 30, 2019 Category: Microbiology Authors: Chang YC, Kuo KC, Sun W, Lin JN, Lai CH, Lee CH Tags: J Microbiol Immunol Infect Source Type: research

Association between sensitized to food allergens and childhood allergic respiratory diseases in Taiwan.
Abstract BACKGROUND: Sensitization to allergen has long been known to be relate to childhood allergic diseases. Polysensitised children have more severe atopic diseases, whereas allergic rhinitis or asthma children with cosensitized to food and inhalant allergens were under-researched. OBJECTIVE: To realize the association between sensitization to food allergens and pediatric allergic rhinitis and asthma in Taiwan. METHODS: We included 138 participants with sensitized to allergen as assessed by serum-specific IgE. 87 of 138 participants had allergic rhinitis and 51 participants had asthma. All participan...
Source: Journal of Microbiology, Immunology, and Infection - April 17, 2019 Category: Microbiology Authors: Wang YH, Lue KH Tags: J Microbiol Immunol Infect Source Type: research

Comparing ceftolozane/tazobactam versus piperacillin/tazobactam as empiric therapy for complicated urinary tract infection in Taiwan: A cost-utility model focusing on gram-negative bacteria.
CONCLUSIONS: Our results suggest that empiric use of ceftolozane/tazobactam for the treatment of cUTI could be a cost-effective choice in Taiwan. PMID: 31029529 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 16, 2019 Category: Microbiology Authors: Chen GJ, Pan SC, Foo J, Morel C, Chen WT, Wang JT Tags: J Microbiol Immunol Infect Source Type: research

Plasma proteome profiling reveals differentially expressed lipopolysaccharide-binding protein among leptospirosis patients.
Abstract BACKGROUND: Human leptospirosis, or commonly known as "rat urine disease" is a zoonotic disease that is caused by the bacteria called Leptospira sp. The incidence rate of leptospirosis has been under-reported due to its unspecific clinical symptoms and the limitations of current laboratory diagnostic methods. Leptospirosis can be effectively treated with antibiotics in the early stage, and it is a curable disease but the accuracy to diagnose the infection is rarely achieved. METHODS: The present pilot study investigated plasma protein profiles of leptospirosis patients and compared them aga...
Source: Journal of Microbiology, Immunology, and Infection - April 13, 2019 Category: Microbiology Authors: Fish-Low CY, Than LTL, Ling KH, Lin Q, Sekawi Z Tags: J Microbiol Immunol Infect Source Type: research

Breakthrough invasive Trichosporon asahii infection in an uremic patient with systemic calciphylaxis complicating necrotizing fasciitis during echinocandin therapy for C. tropicalis.
PMID: 31023578 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 13, 2019 Category: Microbiology Authors: Tsai YH, Wang CH, Hsueh PR, Jean SS, Chen FL, Lee WS Tags: J Microbiol Immunol Infect Source Type: research

The association of pili with the emergence and replacement of the major antibiotic resistant pneumococcal clones.
CONCLUSIONS: Both major antibiotic resistant clones carried PI-1, although they differ in the clade type. Thus the role of PI-1 should be evaluated in further studies and potentially considered in the spread of antibiotic resistant clones. PMID: 31010747 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 11, 2019 Category: Microbiology Authors: Zemlickova H, Jakubu V, Fridrichova M, Malisova L, Martin Musilek, Trojanek M Tags: J Microbiol Immunol Infect Source Type: research

Role of nasal swab culture in guiding antimicrobial therapy for acute cellulitis in the era of community-acquired methicillin-resistant Staphylococcus aureus: A prospective study of 89 patients.
Abstract In this prospective study of 89 patients with acute cellulitis, we showed nasal swab culture of methicillin-resistant Staphylococcus aureus (MRSA), taken at enrollment, has a high specificity of 95% in predicting MRSA cellulitis among the 24 patients whose cellulitis became purulent. However, the sensitivity is only 20%. PMID: 31003927 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 10, 2019 Category: Microbiology Authors: Hsu MS, Liao CH, Fang CT Tags: J Microbiol Immunol Infect Source Type: research

How Streptococcus suis serotype 2 attempts to avoid attack by host immune defenses.
Abstract Streptococcus suis (S. suis) type 2 (SS2) is an important zoonotic pathogen that causes swine streptococcosis, a widespread infectious disease that occurs in pig production areas worldwide and causes serious economic losses in the pork industry. Hosts recognize pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs) to activate both innate and acquired immune responses. However, S. suis has evolved multiple mechanisms to escape host defenses. Pathogenic proteins, such as enolase, double-component regulatory systems, factor H-combining proteins and other pathogenic and v...
Source: Journal of Microbiology, Immunology, and Infection - March 27, 2019 Category: Microbiology Authors: Xia X, Qin W, Zhu H, Wang X, Jiang J, Hu J Tags: J Microbiol Immunol Infect Source Type: research

Effect of Lactobacillus rhamnosus GG immunopathologic changes in chronic mouse asthma model.
CONCLUSIONS: LGG not only had anti-inflammatory effects on OVA-induced airway inflammation, but also improved airway remodeling and collagen expression in the chronic asthma mouse model. Moreover, LGG might be an additional or supplementary therapy for allergic airway diseases. PMID: 30952512 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - March 23, 2019 Category: Microbiology Authors: Wu CT, Lin FH, Lee YT, Ku MS, Lue KH Tags: J Microbiol Immunol Infect Source Type: research

Effects of dietary-fiber levels on RANK/RANKL/OPG expression in the appendix of weanling rabbits.
Abstract BACKGROUND/PURPOSE: The dietary fiber can regulate the intestinal mucosal immunity, and the M cell is the portal for initiating mucosal immunity. We investigated the effects of dietary fiber on the transport of Escherichia coli to assess the function of microfold (M) cells in the appendix. METHOD: A total of 150 New Zealand rabbits were fed three diets (high fiber (HF): 31.72%; control: 37.36%; low dietary fiber (LF): 41.84%; neutral detergent fiber (NDF). An infection model was established in vivo using E. coli containing green fluorescent protein as the indicator in appendix loops. Samples wer...
Source: Journal of Microbiology, Immunology, and Infection - March 16, 2019 Category: Microbiology Authors: Zhu Y, Sun Y, Zhang N, Li F, Zhou H Tags: J Microbiol Immunol Infect Source Type: research

Characterization of lymphocyte subsets in peripheral blood cells of children with EV71 infection.
Abstract BACKGROUND: Enterovirus 71 (EV71) is one of the major causative pathogens of hand, foot, and mouth disease (HFMD). Immune cells play a critical role in determining the outcomes of virus infection. We aimed to characterize the lymphocyte subsets and transcriptional levels of T lymphocytes-associated transcription factors in peripheral blood cells of children with EV71 infection. METHODS: Peripheral blood samples from 32 children with EV71 infection and 32 control subjects were included in this study. The frequencies of T-, B-lymphocytes, and their subsets were determined by flow cytometry. The express...
Source: Journal of Microbiology, Immunology, and Infection - March 14, 2019 Category: Microbiology Authors: Zhao MQ, Wang LH, Lian GW, Lin ZF, Li YH, Guo M, Chen Y, Liu XM, Zhu B Tags: J Microbiol Immunol Infect Source Type: research

Diagnostic surveillance by Candida albicans germ tube antibody in intensive care unit patients.
CONCLUSIONS: Our results suggest that detection of CAGTA could be a useful biomarker for the diagnosis of proven and probable IC in critical patients during prolonged ICU stay. During the monitoring it is opportune to evaluate the titers kinetics since the clinical diagnosis of proven/probable IC coincided with increase titer from negative (
Source: Journal of Microbiology, Immunology, and Infection - March 11, 2019 Category: Microbiology Authors: Trovato L, Astuto M, Castiglione G, Scalia G, Oliveri S Tags: J Microbiol Immunol Infect Source Type: research

The microbiological characteristics of lower respiratory tract infection in patients with neuromuscular disorders: An investigation based on a multiplex polymerase chain reaction to detect viruses and a clone library analysis of the bacterial 16S rRNA gene sequence in sputum samples.
Abstract We performed gene amplification methods for the detections of bacteria and viruses using sputum samples to clarify the microbiological characteristics of lower respiratory tract infection in patients with neuromuscular disorders. The tendencies of higher proportion of respiratory virus detection and lower diversity of bacteria in sputum were observed. PMID: 30898603 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - March 8, 2019 Category: Microbiology Authors: Ogawa M, Hoshina T, Haro K, Kumadaki T, Ishii M, Fujino Y, Fukuda K, Kusuhara K Tags: J Microbiol Immunol Infect Source Type: research

Differential dynamics of hepatic protein expressions with long-term cultivated hepatitis C virus infection.
In this study, comparative proteomic analysis was performed in HCV-infected and mock-control Huh7 cells according to the viral dynamics of exponential, plateau, declined, and silencing phases at the acute stage, and the chronic stage. The proteins with
Source: Journal of Microbiology, Immunology, and Infection - February 21, 2019 Category: Microbiology Authors: Tsai P, Lin TY, Cheng SL, Sun HY, Chen SF, Young KC Tags: J Microbiol Immunol Infect Source Type: research

Molecular characterization of vancomycin-resistant enterococci isolated from a hospital in Beijing, China.
CONCLUSION: This study confirms that VREfm isolates associated with ST78 were the main epidemic lineage responsible for nosocomial infections in China, as were also observed in other nations worldwide. PMID: 30827858 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - February 11, 2019 Category: Microbiology Authors: Sun HL, Liu C, Zhang JJ, Zhou YM, Xu YC Tags: J Microbiol Immunol Infect Source Type: research

Identification of a novel protein in the genome sequences of Leptospira interrogans with the ability to interact with host's components.
CONCLUSIONS: This novel leptospiral protein may function as an adhesin at the colonization steps and may help the invasion process by plasmin generation at the bacterial cell surface. PMID: 30713004 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - January 22, 2019 Category: Microbiology Authors: Rossini AD, Teixeira AF, Souza Filho A, Souza GO, Vasconcellos SA, Heinemann MB, Romero EC, Nascimento ALTO Tags: J Microbiol Immunol Infect Source Type: research

Distribution of virulence genes in bacteremic methicillin-resistant Staphylococcus aureus isolates from various sources.
CONCLUSIONS: A major MRSA lineage, CC8-ST239-MRSA-SCCmec type III-spa type t037, is noted among bacteremic MRSA isolates. No disease-specific virulent genes can be identified. PMID: 30686615 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - January 10, 2019 Category: Microbiology Authors: Wang FD, Wu PF, Chen SJ Tags: J Microbiol Immunol Infect Source Type: research

Microbiology of peritoneal dialysis-related infection and factors of refractory peritoneal dialysis related peritonitis: A ten-year single-center study in Taiwan.
Abstract BACKGROUND: Peritoneal dialysis (PD)-related infection is a serious complication of patients with PD. Refractory peritonitis may lead to failure of PD, shift to hemodialysis (HD) or death. Besides, microbiologic resistance increased worldwide that might impact the treatment choice for such infections. Investigating the causative pathogens and risk factors of PD-related infections in Taiwan was warranted. METHODS: This is a retrospective study involving patients with PD from 2007 to 2016 in a southern Taiwan hospital. Patient characteristics, microbiological data, outcomes, and factors associated with...
Source: Journal of Microbiology, Immunology, and Infection - January 8, 2019 Category: Microbiology Authors: Wang HH, Huang CH, Kuo MC, Lin SY, Hsu CH, Lee CY, Chiu YW, Chen YH, Lu PL Tags: J Microbiol Immunol Infect Source Type: research

Postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis: Clinical analysis of 12 clustered adults and a proposed therapeutic algorithm.
Abstract PURPOSE: Postoperative endophthalmitis caused by nontuberculous mycobacterium is a rare but devastating complication after intraocular surgery. However, optimal treatment strategies remain undetermined in view of its rarity. METHODS: We investigated the cases of culture-proven postoperative Mycobacteroides abscessus subsp. abscessus endophthalmitis in southern Taiwan, focusing on clinical manifestations and microbiological study, and aimed to describe clinical staging and to propose a therapeutic modality for this disease. RESULTS: Twelve cases, including two published cases, were treated in two...
Source: Journal of Microbiology, Immunology, and Infection - January 6, 2019 Category: Microbiology Authors: Hung JH, Ko WC, Chen CY, Lin SH, Wu CL, Hsu SM, Teng YT, Wang SH, Tseng SH, Huang FC, Lai CC, Chen CL, Lai CH, Chen PL, Jou-Chen Huang E Tags: J Microbiol Immunol Infect Source Type: research

Long-term outcomes in lupus patients receiving different renal replacement therapy.
CONCLUSION: The patients with ESRD caused by lupus nephritis who underwent KT had better long-term outcomes and survival rates than those who received HD or PD. This implies that KT is the better choice of renal replacement therapy in the patients with ESRD caused by lupus nephritis. PMID: 30642809 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - January 4, 2019 Category: Microbiology Authors: Tsai WT, Chang HC, Wang CT, Chiang BL, Lin YT Tags: J Microbiol Immunol Infect Source Type: research

Synergistic effect of linezolid with fosfomycin against Staphylococcus aureus in  vitro and in an experimental Galleria mellonella model.
CONCLUSION: This work indicated that linezolid combination with fosfomycin has synergistic effect against S. aureus in vitro and in an experimental G. mellonella model, and it suggests that high-dose of linezolid and fosfomycin may not necessary. PMID: 30638785 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 31, 2018 Category: Microbiology Authors: Li L, Chen H, Liu Y, Xu S, Wu M, Liu Z, Qi C, Zhang G, Li J, Huang X Tags: J Microbiol Immunol Infect Source Type: research

Roles of Toll-Like Receptor 4 for Cellular Pathogenesis in Primary Open-Angle Glaucoma: A potential therapeutic strategy.
Abstract In recent years, glaucoma has been proposed as an autoimmune disease and an understanding immune-regulation concept has been applied for novel glaucoma therapy. Current evidence suggests an innate immunity is a keystone step for primary open angle glaucoma (POAG) pathogenesis resulting from trabecular meshwork (TM) cell fibrosis and retinal ganglion cell (RGC) death. Toll-like receptor 4 (TLR4) is a common player in the innate immunity, which appears on the TM and RGC of POAG. The activation of TLR4 regulates several molecules involving both fibrosis and cell death. Inhibition of TLR4 decreases TGF-β...
Source: Journal of Microbiology, Immunology, and Infection - December 27, 2018 Category: Microbiology Authors: Poyomtip T Tags: J Microbiol Immunol Infect Source Type: research

Integrated safety summary of phase II and III studies comparing oral nemonoxacin and levofloxacin in community-acquired pneumonia.
CONCLUSION: Nemonoxacin was well tolerated and no clinically significant safety concerns were identified, suggesting that it possesses a desirable safety and tolerability profile similar to that of levofloxacin, and may be a suitable alternative to fluoroquinolones for treating patients with CAP. PMID: 30616912 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - December 21, 2018 Category: Microbiology Authors: Cheng SL, Wu RG, Chuang YC, Perng WC, Tsao SM, Chang YT, Chang LW, Hsu MC Tags: J Microbiol Immunol Infect Source Type: research

The clinical features and mortality risk factors of cytomegalovirus infection in patients with systemic lupus erythematosus.
Abstract BACKGROUND: The clinical features and outcomes of cytomegalovirus (CMV) diseases in patients with systemic lupus erythematosus (SLE) are unknown. We analyzed such data from a medical center in Taiwan. METHODS: We retrospectively reviewed the medical records of patients with SLE who were diagnosed with CMV diseases between 2006 and 2016 in Taipei Veterans General Hospital Taiwan. Clinical and laboratory parameters and treatment outcomes were analyzed. RESULTS: The study enrolled 56 eligible patients with CMV diseases and separated them into survival (n = 24) and mortality (n = ...
Source: Journal of Microbiology, Immunology, and Infection - December 16, 2018 Category: Microbiology Authors: Hung M, Huang DF, Chen WS, Lai CC, Chen MH, Liao HT, Tsai CY Tags: J Microbiol Immunol Infect Source Type: research

High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan.
Abstract BACKGROUND/PURPOSES: Human rhinovirus type C (HRV-C) has been associated with asthma exacerbation (AE) in children in several countries. However, in Taiwan the association between HRV, especially HRV-C, and AE in children has yet to be elucidated. We sought to investigate the prevalence of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Taiwan and the association between different types of HRV and AE in children. METHODS: This prospective study was conducted from 2011 to 2013, and enrolled children with ALRTI, including an asthma exacerbation group (AE; n ...
Source: Journal of Microbiology, Immunology, and Infection - December 15, 2018 Category: Microbiology Authors: Su YT, Lin YT, Yang CC, Tsai SS, Wang JY, Huang YL, Lin TI, Lin TM, Tsai YC, Yu HR, Tsai CC, Yang MC Tags: J Microbiol Immunol Infect Source Type: research

Immune response to asymptomatic infections by Entamoeba histolytica and other enteric pathogens in pregnant women and their infants in a high HIV burdened setting in Zimbabwe.
Abstract BACKGROUND: Asymptomatic Entamoeba histolytica infections in pregnant women puts infants at risk of infection through vertical transmission or transmission during breastfeeding in high HIV prevalence areas. The study aimed at investigating the immune response to asymptomatic E.histolytica infection in pregnant women and their infants in a high HIV burdened setting in Harare, Zimbabwe. METHODOLOGY: Serum samples from 39 predominantly breastfeeding mother-infant pairs were analyzed for inflammatory cytokine and immunoglobulin profiles using BIOPLEX. The infants' ages ranged from 10 days to 14 weeks. ...
Source: Journal of Microbiology, Immunology, and Infection - December 7, 2018 Category: Microbiology Authors: Nhidza AF, Naicker T, Stray-Pedersen B, Chisango TJ, Sibanda EP, Ismail A, Bandason T, Makaza C, Duri K, Mduluza T Tags: J Microbiol Immunol Infect Source Type: research

Bloodstream infections in hospitalized adults with dengue fever: Clinical characteristics and recommended empirical therapy.
CONCLUSIONS: BSI pathogens vary among dengue patients. For adults with dengue and suspected BSI hospitalized within one week, empirical antimicrobial agents are recommended. PMID: 30528336 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - November 23, 2018 Category: Microbiology Authors: Syue LS, Tang HJ, Hung YP, Chen PL, Li CW, Li MC, Tsai PF, Liu CC, Lee NY, Ko WC Tags: J Microbiol Immunol Infect Source Type: research

Potential role of autophagy in proteolysis in Trichomonas vaginalis.
CONCLUSION: Our findings unveiled previously unidentified functions of autophagy in proteostasis in trichomonads, advancing our understanding of this highly conserved process in the ancient eukaryote. PMID: 30503389 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - November 22, 2018 Category: Microbiology Authors: Huang KY, Chen RM, Lin HC, Cheng WH, Lin HA, Lin WN, Huang PJ, Chiu CH, Tang P Tags: J Microbiol Immunol Infect Source Type: research

Subdural effusion and ischemic stroke complicating meningococcal meningitis in an adult.
PMID: 30497911 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - November 22, 2018 Category: Microbiology Authors: Chang CY, Chiu TL, Chang PY, Hu CM, Wang LS Tags: J Microbiol Immunol Infect Source Type: research

Using groEL as the target for identification of Enterococcus faecium clades and 7 clinically relevant Enterococcus species.
CONCLUSION: The simple PCR-RFLP and multiplex PCR assays on the basis of groEL gene provided an alternative way to identify Enterococcus species. PMID: 30473144 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - November 14, 2018 Category: Microbiology Authors: Hung WW, Chen YH, Tseng SP, Jao YT, Teng LJ, Hung WC Tags: J Microbiol Immunol Infect Source Type: research

Coinfection of pneumocystis jiroveci pneumonia and pulmonary aspergillosis in a non-HIV-infected patient.
PMID: 30473143 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - November 12, 2018 Category: Microbiology Authors: Lee PH, Fu PK Tags: J Microbiol Immunol Infect Source Type: research

Genitourinary tuberculosis in Taiwan: A 15-year experience at a teaching hospital.
CONCLUSION: GUTB is often in advanced stages with a high mortality in Taiwan. Establishing a diagnosis is difficult and requires thorough investigation. Fever is associated with unfavorable outcome. PMID: 30472096 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - November 9, 2018 Category: Microbiology Authors: Huang TY, Hung CH, Hsu WH, Peng KT, Hung MS, Lai LJ, Chuang HJ, Tai WL, Ku YP, Wu TS Tags: J Microbiol Immunol Infect Source Type: research

Characterization of microRNA profile in IgE-mediated mouse BMMCs degranulation.
Abstract BACKGROUND: Mast cells play a central role in innate and adaptive immunity by releasing pre-formed and de novo synthesized mediators, which include microRNAs. Although miRNAs have been confirmed to function in cell proliferation, differentiation, apoptosis, and the immune response, their functions are still limited in mast cells degranulation. METHODS: Here, we survey miRNA expression profiles in activated mouse bone marrow-derived mast cells (BMMCs) with a miRNA microarray and compare the profiles to those from resting BMMCs. Partial miRNAs were selected for confirmation by qPCR, and let-7i was sele...
Source: Journal of Microbiology, Immunology, and Infection - November 9, 2018 Category: Microbiology Authors: Li Y, Liu J, Zhang J, Zhang W, Wu Z Tags: J Microbiol Immunol Infect Source Type: research

Cytokine profiles in cerebrospinal fluid of patients with meningitis at a tertiary general hospital in China.
Abstract BACKGROUND: There has been a great deal of evidence indicating that cytokines participate in meningeal inflammation. Different cytokine profiles may be presented in central nervous system (CNS) infection due to different pathogens. We have attempted to investigate cytokine profiles in cerebrospinal fluid (CSF) of patients with CNS infection. METHODS: Forty-three patients with CNS infection including tuberculous meningitis, purulent meningitis and cryptococcal meningitis were enrolled and 11 patients with normal CSF were enrolled as control group. The concentrations of Th1-, Th2- and Th17-type cytokin...
Source: Journal of Microbiology, Immunology, and Infection - November 9, 2018 Category: Microbiology Authors: Liu Q, Gao Y, Zhang B, Sun F, Yang Q, Liu Y, Wu J, Chen K, Weng X, Zhang W, Huang R, Shao L Tags: J Microbiol Immunol Infect Source Type: research

Clonal relationship and the association of the ST218 strain harboring blaOXA-72 gene to mortality in carbapenem-resistant Acinetobacter baumannii bacteremia.
CONCLUSION: This study showed the clonal relationship of isolates harboring the carbapenemase gene in CRAB bacteremia. Patients with the ST218 strain harboring blaOXA-72 gene had high mortality. This warrants further research to determine the mechanism of virulence and risk factors in order to reduce mortality. PMID: 30448082 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - November 5, 2018 Category: Microbiology Authors: Liu CP, Lu HP, Luor T Tags: J Microbiol Immunol Infect Source Type: research

Effect of multi-ethnicity and ancestry on prevalence of allergic disease.
CONCLUSION: Population admixing appears to have significant effect on the prevalence of allergic disease. Further study will be needed to clarify the effect of population admixing on prevalence of allergic disease. PMID: 30424947 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - October 31, 2018 Category: Microbiology Authors: Kim JT, Kim HS, Chun YH, Yoon JS, Kim HH Tags: J Microbiol Immunol Infect Source Type: research

Treatment of allergic rhinitis reduces acute asthma exacerbation risk among asthmatic children aged 2-18 years.
CONCLUSION: The preschool patients had a higher incidence of AE than the older patients in general. Adequate treatment with INCS and/or SGH in asthma with AR patients is important for reducing the incidence of AE of asthma. PMID: 30409760 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - October 25, 2018 Category: Microbiology Authors: Yu CL, Huang WT, Wang CM Tags: J Microbiol Immunol Infect Source Type: research

Galectin-9-like from Angiostrongylus cantonensis young adult worms modulates eosinophil chemotaxis in  vitro.
CONCLUSION: Galectin-9-like in AcYA and galectin-9 in mouse CSF were confirmed demonstrating eosinophil chemotactic activity both in vitro study and in the infection of mouse in this study. PMID: 30404740 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - October 18, 2018 Category: Microbiology Authors: Wang JJ, Wu ZS, Chung LY, Lu CY, Yen CM Tags: J Microbiol Immunol Infect Source Type: research

Evaluation of cost-effectiveness of peginterferon plus ribavirin for chronic hepatitis C treatment and direct-acting antiviral agents among HIV-infected patients in the prison and community settings.
Abstract BACKGROUND: In Taiwan, the majority of chronic hepatitis C carriers with HIV co-infection are intravenous drug users and inmates in correctional facilities. Peginterferon and ribavirin (PegIFN/RBV) have been the standard-of-care for chronic hepatitis C virus (HCV) infection more than decades. We evaluated the estimated cost-effectiveness of PegIFN/RBV from the National Health Insurance Research Database, covering the population of Taiwan from 1998 to 2013. MATERIALS AND METHODS: This is an observational study, and study during was 2010-2016 and a total of 239 patients were treated with PegIFN/RBV. Of...
Source: Journal of Microbiology, Immunology, and Infection - October 12, 2018 Category: Microbiology Authors: Chen CP, Cheng CY, Zou H, Cheng CH, Cheng SH, Chen CK, Chen CH, Bair MJ Tags: J Microbiol Immunol Infect Source Type: research

Evaluation of ompK36 allele groups on clinical characteristics and virulence features of Klebsiella pneumoniae from bacteremia.
CONCLUSION: Our results suggest that the OmpK36 group C K.pneumoniae is more associated with community-acquired infection with a lower frequency of underlying illness, but with significantly more virulence in bloodstream infection. This would give a remind that clinicians should be aware of such clinical impacts of the ompK36 allele group. PMID: 30348614 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - October 9, 2018 Category: Microbiology Authors: Du F, Wei DD, Wan LG, Cao XW, Zhang W, Liu Y Tags: J Microbiol Immunol Infect Source Type: research

Mycoplasma pneumoniae in pediatric patients: Do macrolide-resistance and/or delayed treatment matter?
Abstract BACKGROUND: Mycoplasma pneumoniae is a common pathogen for pneumonia in children, especially in the post-pneumococcal conjugate vaccination era. Though self-limited disease was found in the majority of the patients, severe diseases occurred occasionally. The emergence of macrolide resistance was reported worldwide. It is important to delineate whether macrolide resistance or delayed treatment affects outcome. METHODS: We retrospectively collected pediatric patients with M. pneumoniae infection confirmed by positive PCR in a tertiary medical center in Taiwan from 2010 to 2017. Patients' clinical chara...
Source: Journal of Microbiology, Immunology, and Infection - October 9, 2018 Category: Microbiology Authors: Yang TI, Chang TH, Lu CY, Chen JM, Lee PI, Huang LM, Chang LY Tags: J Microbiol Immunol Infect Source Type: research

Implementation of a national quality improvement program to enhance hand hygiene in nursing homes in Taiwan.
CONCLUSIONS: A national quality-improvement program using WHO's hand-hygiene strategy to enhance hand hygiene and reduce healthcare associated infection is effective in nursing homes in Taiwan. PMID: 30316727 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 28, 2018 Category: Microbiology Authors: Lai CC, Lu MC, Tang HJ, Chen YH, Wu YH, Chiang HT, Wu LH, Ko WC, Hsueh PR, Chen YH, for Infection Control Society of Taiwan Tags: J Microbiol Immunol Infect Source Type: research

Real-world effectiveness of direct-acting antiviral agents for chronic hepatitis C in Taiwan: Real-world data.
Abstract BACKGROUND/PURPOSE: Treatment of chronic hepatitis C (CHC) has entered a new era since the introduction of direct-acting antiviral agents (DAAs). Numerous clinical trials have shown that treatment response as well as tolerability of DAAs are superior to those of conventional therapy with pegylated interferon and ribavirin. However, the results of clinical trials may not be directly applied to real-world practice. Therefore our study tried to investigate the effectiveness of various DAA regimens in Taiwanese patients with chronic hepatitis C. METHODS: We performed a retrospective study on 400 CHC pati...
Source: Journal of Microbiology, Immunology, and Infection - September 26, 2018 Category: Microbiology Authors: Hong CM, Liu CH, Su TH, Yang HC, Chen PJ, Chen YW, Kao JH, Liu CJ Tags: J Microbiol Immunol Infect Source Type: research