Investigation of a nosocomial outbreak of fungemia caused by Candida pelliculosa (Pichia anomala) in a Korean tertiary care center
ConclusionsThis is the first report of a nosocomial outbreak involving 11 patients in 2 ICUs and 2 general wards caused by C. pelliculosa in South Korea. Infection control measures are important for decreasing transmission of C. pelliculosa in the hospital. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Clinical characteristics, radiologic findings, risk factors and outcomes of serum galactomannan-negative invasive pulmonary aspergillosis
ConclusionNeutropenia and prior receipt of mold-active antifungal drugs before GM assay were independently associated with GM positivity among patients with proven/probable IPA. Angioinvasive aspergillosis was less common in GM-negative IPA than in GM-positive IPA. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Low-dose trimethoprim-sulfamethoxazole treatment for pneumocystis pneumonia in non-human immunodeficiency virus-infected immunocompromised patients: A single-center retrospective observational cohort study
ConclusionLow-dose TMP-SMX may be a treatment option for patients with non-HIV PCP. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - December 2, 2018 Category: Microbiology Source Type: research

Bloodstream infections in hospitalized adults with dengue fever: clinical characteristics and recommended empirical therapy
ConclusionsBSI pathogens vary among dengue patients. For adults with dengue and suspected BSI hospitalized within one week, empirical antimicrobial agents are recommended. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 23, 2018 Category: Microbiology Source Type: research

Potential role of autophagy in proteolysis in Trichomonas vaginalis
ConclusionOur findings unveiled previously unidentified functions of autophagy in proteostasis in trichomonads, advancing our understanding of this highly conserved process in the ancient eukaryote. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 22, 2018 Category: Microbiology Source Type: research

Subdural effusion and ischemic stroke complicating meningococcal meningitis in an adult
Publication date: Available online 22 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chun-Yu Chang, Tsung-Lang Chiu, Pau-Yuan Chang, Chih-Ming Hu, Lih-Shinn Wang (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 22, 2018 Category: Microbiology Source Type: research

Increased mcr-1 in Pathogenic Escherichia coli from Diseased Swine, Taiwan
Publication date: Available online 20 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Jing-Yi Liu, Tsai-Lien Liao, Wei-Cheng Huang, Yen-Ming Liu, Keh-Ming Wu, Tsai-Ling Lauderdale, Shih-Feng Tsai, Shu-Chen Kuo, Hung-Chih KuoAbstractPurposeTo investigate the increasing prevalence of colistin resistance in animal Escherichia coli isolates and their mcr-1-carrying plasmids, especially those shared by isolates from human and retail meats.MethodsE. coli from diseased swine and poultry recovered between 2012 and 2016 were studied. Susceptibility was determined using broth microdilution method or ...
Source: Journal of Microbiology, Immunology and Infection - November 21, 2018 Category: Microbiology Source Type: research

The first case of Klebsiella pneumoniae liver abscess with hemophagocytic lymphohistiocytosis
Publication date: Available online 20 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Ying-Ting Liao, Po-Shen Ko, Yi-Tsung Lin (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 21, 2018 Category: Microbiology Source Type: research

Immune Response To Purified Protein Derivative In Infants From Helminth-Sensitized Mothers - A Cases Series
In conclusion, infants with Th1 and Th2 profile chemokines demonstrated a good response to vaccination, indicated by CXCL10 levels, but not infants predominantly Th2-skewed profile. These results highlight that children from mothers sensitized to S. mansoni may lead to ineffective immune response to PPD, while mothers sensitized to A. lumbricoides showed no such impairment. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 18, 2018 Category: Microbiology Source Type: research

Temporal-spatial expressions of interleukin-4, interleukin-10, and interleukin-13 in the brains of C57BL/6 and BALB/c mice infected with Angiostrongylus cantonensis: An immunohistochemical study
ConclusionThe special temporal-spatial expression changes of these three cytokines in the infected mouse brain may explain the differences in the survival and the time of occurrence of immune responses in the hosts after A. cantonensis infection. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 18, 2018 Category: Microbiology Source Type: research

Using groEL as the target for identification of Enterococcus faecium clades and 7 clinically relevant Enterococcus species
ConclusionThe simple PCR-RFLP and multiplex PCR assays on the basis of groEL gene provided an alternative way to identify Enterococcus species. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 14, 2018 Category: Microbiology Source Type: research

Coinfection of Pneumocystis jiroveci pneumonia and pulmonary aspergillosis in a non-HIV-infected patient
Publication date: Available online 12 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Po-Hsin Lee, Pin-Kuei Fu (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 12, 2018 Category: Microbiology Source Type: research

Genitourinary Tuberculosis in Taiwan: a 15-year Experience at a Teaching Hospital
ConclusionGUTB is often in advanced stages with a high mortality in Taiwan. Establishing a diagnosis is difficult and requires thorough investigation. Fever is associated with unfavorable outcome. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 9, 2018 Category: Microbiology Source Type: research

Cytokine profiles in cerebrospinal fluid of patients with meningitis at a tertiary general hospital in China
Publication date: Available online 9 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Qianqian Liu, Yan Gao, Bingyan Zhang, Feng Sun, Qingluan Yang, Yuanyuan Liu, Jing Wu, Kun Chen, Xinhua Weng, Wenhong Zhang, Ruofan Huang, Lingyun ShaoAbstractBackgroundThere has been a great deal of evidence indicating that cytokines participate in meningeal inflammation. Different cytokine profiles may be presented in central nervous system (CNS) infection due to different pathogens. We have attempted to investigate cytokine profiles in cerebrospinal fluid (CSF) of patients with CNS infection.MethodsForty-...
Source: Journal of Microbiology, Immunology and Infection - November 9, 2018 Category: Microbiology Source Type: research

Characterization of microRNA profile in IgE-mediated mouse BMMCs degranulation
Publication date: Available online 9 November 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Yanhong Li, Jie Liu, Jiaojiao Zhang, Wenjin Zhang, Zhengli WuAbstractBackgroundMast cells play a central role in innate and adaptive immunity by releasing pre-formed and de novo synthesized mediators, which include microRNAs. Although miRNAs have been confirmed to function in cell proliferation, differentiation, apoptosis, and the immune response, their functions are still limited in mast cells degranulagion.MethodsHere, we survey miRNA expression profiles in activated mouse bone marrow-derived mast cells (...
Source: Journal of Microbiology, Immunology and Infection - November 9, 2018 Category: Microbiology Source Type: research

Clonal relationship and the association of the ST218 strain harboring blaOXA-72 gene to mortality in carbapenem-resistant Acinetobacter baumannii bacteremia
ConclusionThis study showed the clonal relationship of isolates harboring the carbapenemase gene in CRAB bacteremia. Patients with the ST218 strain harboring blaOXA-72 gene had high mortality. This warrants further research to determine the mechanism of virulence and risk factors in order to reduce mortality. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 6, 2018 Category: Microbiology Source Type: research

Effect of Multi-ethnicity and Ancestry on Prevalence of Allergic Disease
ConclusionPopulation admixing appears to have significant effect on the prevalence of allergic disease. Further study will be needed to clarify the effect of population admixing on prevalence of allergic disease. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 31, 2018 Category: Microbiology Source Type: research

Treatment of allergic rhinitis reduces acute asthma exacerbation risk among asthmatic children aged 2-18 years
ConclusionThe preschool patients had a higher incidence of AE than the older patients in general. Adequate treatment with INCS and/or SGH in asthma with AR patients is important for reducing the incidence of AE of asthma. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 26, 2018 Category: Microbiology Source Type: research

Galectin-9-like from Angiostrongylus cantonensis young adult worms modulates eosinophil chemotaxis in vitro
ConclusionGalectin-9-like in AcYA and galectin-9 in mouse CSF were confirmed demonstrating eosinophil chemotactic activity both in vitro study and in the infection of mouse in this study. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 19, 2018 Category: Microbiology Source Type: research

Evaluation of cost-effectiveness of peginterferon plus ribavirin for chronic hepatitis C treatment and direct-acting antiviral agents among HIV-infected patients in the prison and community settings
Publication date: Available online 12 October 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Cheng-Pin Chen, Chien-Yu Cheng, Huachun Zou, Chun-Han Cheng, Shu-Hsing Cheng, Cheng-Kuo Chen, Ching-Hsiang Chen, Ming-Jong BairAbstractBackgroundIn Taiwan, the majority of chronic hepatitis C carriers with HIV co-infection are intravenous drug users and inmates in correctional facilities. Peginterferon and ribavirin (PegIFN/RBV) have been the standard-of-care for chronic hepatitis C virus (HCV) infection more than decades. We evaluated the estimated cost-effectiveness of PegIFN/RBV from the National Health ...
Source: Journal of Microbiology, Immunology and Infection - October 12, 2018 Category: Microbiology Source Type: research

Characterization of stm3030 and stm3031 genes of Salmonella enterica serovar Typhimurium in relation to cephalosporin resistance
ConclusionOur data indicate that STM3030 has a chaperone-like activity and may modulate or stabilize STM3031, leading to resistance of S. enterica serovar Typhimurium to cephalosporin drugs. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 11, 2018 Category: Microbiology Source Type: research

Serodiagnosis and early detection of Strongyloides stercoralis infection
This article summarizes human strongyloidiasis and the available diagnostic tools for the disease, focusing on describing the current antibody assays for strongyloidiasis. Finally, prospects of developing a more effective serodiagnostic tool for strongyloidiasis are discussed. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 11, 2018 Category: Microbiology Source Type: research

Evaluation of ompK36 allele groups on Clinical Characteristics and Virulence Features of Klebsiella pneumoniae from Bacteremia
ConclusionOur results suggest that the OmpK36 group C K.pneumoniae is more associated with community-acquired infection with a lower frequency of underlying illness, but with significantly more virulence in bloodstream infection. This would give a remind that clinicians should be aware of such clinical impacts of the ompK36 allele group. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 9, 2018 Category: Microbiology Source Type: research

Mycoplasma pneumoniae in pediatric patients: do macrolide-resistance and/or delayed treatment matter?
Publication date: Available online 9 October 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Tzu-I. Yang, Tu-Hsuan Chang, Chun-Yi Lu, Jong-Min Chen, Ping-Ing Lee, Li-Min Huang, Luan-Yin ChangAbstractBackgroundMycoplasma pneumoniae is a common pathogen for pneumonia in children, especially in the post-pneumococcal conjugate vaccination era. Though self-limited disease was found in the majority of the patients, severe diseases occurred occasionally. The emergence of macrolide resistance was reported worldwide. It is important to delineate whether macrolide resistance or delayed treatment affects outco...
Source: Journal of Microbiology, Immunology and Infection - October 9, 2018 Category: Microbiology Source Type: research

Monitoring early developed low bone mineral density in HIV-infected patients by intact parathyroid hormone and circulating fibroblast growth factor 23
ConclusionsThis cohort-based survey showed a high prevalence of low BMD among HIV-infected adults which included young-age patient in an university hospital. Secondary hyperparathyroidism was significantly associated with low BMD. There was no association between FGF23 and low BMD. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Concurrent Campylobacter jejuni bacteremia and intussusception in an immunocompetent five-year-old child
Publication date: Available online 24 September 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Po-Wei Wu, Chih-Chien WangAbstractBacterial enteritis has been reported to be a risk factor for childhood intussusception. However, no case report concerning children with concurrent Campylobactor bacteremia and intussusception were found in the literature.Herein, we report a 5-year-old male preschool child who presented symptoms of infectious diarrhea, and ileocecal type intussuscepton and Campylobactor jejuni bacteremia were found after a series of investigations. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Invasive mold infections in acute leukemia patients undergoing allogeneic hematopoietic stem cell transplantation
ConclusionsWe identified four risk factors-unrelated donor transplantation, smoking, EBMT risk score> 2 and moderate to severe cGVHD to predict IMIs among acute leukemia patients undergoing allo-HSCT. This cohort study suggests early identification of high-risk patients and to provide better prevention strategies would reduce the incidence and severity of IMIs in these patients. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Real-world effectiveness of direct-acting antiviral agents for chronic hepatitis C in Taiwan: real-world data
Publication date: Available online 26 September 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chun-Ming Hong, Chen-Hua Liu, Tung-Hung Su, Hung-Chih Yang, Pei-Jer Chen, Yu-Wen Chen, Jia-Horng Kao, Chun-Jen LiuAbstractBackground/purposeTreatment of chronic hepatitis C (CHC) has entered a new era since the introduction of direct-acting antiviral agents (DAAs). Numerous clinical trials have shown that treatment response as well as tolerability of DAAs are superior to those of conventional therapy with pegylated interferon and ribavirin. However, the results of clinical trials may not be directly appli...
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Implementation of a national quality improvement program to enhance hand hygiene in nursing homes in Taiwan
ConclusionsA national quality-improvement program using WHO's hand-hygiene strategy to enhance hand hygiene and reduce healthcare associated infection is effective in nursing homes in Taiwan. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir
ConclusionFavipiravir as a chain terminator would not be incorporated and replicate to cause lethal mutagenesis as a mutagen like ribavirin, and resistant mutants were not isolated. A high replication level would generate mutations leading to favipiravir resistance as ribavirin resistance was generated, but generated mutations would be lethal to the RNA polymerase function. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Inactivated Orf-virus shows disease modifying antiviral activity in a guinea pig model of genital herpesvirus infection
ConclusioniORFV effectively suppressed recurrences in guinea pigs experimentally infected with HSV. iORFV did not only reduce recurrent disease episodes but was, compared with ACV, more effective in reducing latency as measured by viral DNA detected in dorsal root ganglia of infected animals. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Impact of broad-spectrum antimicrobial treatment on the ecology of intestinal flora
ConclusionThe patients who received treatment of ertapenem may have a lower risk of rectal colonization for ertapenem resistant Escherichia coli than those who received flomoxef or moxifloxacin. The rate of Pseudomonas colonization did not differ between the three study Pseudomonas-sparing agents. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine
ConclusionFIP-fve had anti-inflammatory effects on OVA-induced airway inflammation and an effect to inhibited Th17 cells to reduced airway remodeling and collagen expression. Moreover, FIP-fve might be a potential alternative therapy for allergic airway diseases. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Association of EV71 3C polymorphisms with clinical severity
Publication date: October 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 5Author(s): Hsuan-Yin Ma, Chun-Yi Lu, Kuo-Chien Tsao, Hsiu-Ming Shih, Ai-Ling Cheng, Li-Min Huang, Luan-Yin ChangAbstractObjectivesEnterovirus 71 (EV71) may cause neurological and fatal cases. EV71 3C plays an important role on viral replication and possess proteolysis activity. To delineate pathogenesis of EV71 virulence, we studied EV71 3C genetics, protease activity and correlated the results with clinical severity.MethodsEV71 cases were collected; 3C of EV71 was sequenced and linked with clinical severity. 3C prote...
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Clinical features and dynamic ordinary laboratory tests differentiating dengue fever from other febrile illnesses in children
ConclusionLeukopenia, thrombocytopenia, elevated aPTT, elevated transaminase levels, and low CRP could be used to differentiate dengue fever from other febrile illnesses. During dengue epidemics, combinations of the symptoms and laboratory findings are helpful to physicians for accurate diagnosis of dengue fever. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Risk factors and outcomes for the acquisition of carbapenem-resistant Gram-negative bacillus bacteremia: A retrospective propensity-matched case control study
Publication date: October 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 5Author(s): Shih-Wen Ting, Chen-Hsiang Lee, Jien-Wei LiuAbstractBackground/purposeA substantial number of carbapenem-resistant Gram-negative bacilli (CR GNB) have been identified among the etiologic multidrug-resistant GNB in healthcare-associated infections. For achieving a better therapeutic outcome by minimizing inappropriate empirical antibiotic treatment before blood culture and susceptibility testing results are available, it is very important to identify patients who are at risk for the development of CR GNB bac...
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Community-acquired bloodstream infections caused by Acinetobacter baumannii: A matched case–control study
ConclusionCommunity-acquired bacteremia caused by A. baumannii was rare but associated with a severe outcome. Further investigation of potential virulence factors of community-acquired A. baumannii is required. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

In vitro activity of aminoglycosides, clofazimine, d-cycloserine and dapsone against 83 Mycobacterium avium complex clinical isolates
ConclusionWhen treating MAC diseases, species identification plays an important role in choosing treatment regimens. Combination of isepamicin and clofazimine may be a promising regimen in M. intracellulare-associated disease. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Multimodal interventions for bundle implementation to decrease central line-associated bloodstream infections in adult intensive care units in a teaching hospital in Taiwan, 2009–2013
This study investigated the sustained effect of multimodal interventions focusing on CL bundle improvement in the adult intensive care units (ICUs) of a teaching hospital in Taiwan.MethodsA before–after prospective study was conducted in 17 adult ICUs of a medical center in northern Taiwan from January 2009 to December 2013. Many interventions that aimed to facilitate CL bundle implementation were initiated in January 2011. The incidence rates of CLABSI and catheter-related bloodstream infection (CRBSI) were compared between the baseline and intervention periods. Catheter utilization ratios and microbiological charac...
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

A simple method for rapid microbial identification from positive monomicrobial blood culture bottles through matrix-assisted laser desorption ionization time-of-flight mass spectrometry
ConclusionWe conclude that this method is feasible for clinical use in microbiology laboratories, and can serve as a reference for treatments or further complementary diagnostic testing. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Routine CD4 monitoring in HIV patients with viral suppression: Is it really necessary? A Portuguese cohort
Publication date: October 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 5Author(s): Raquel Duro, Nuno Rocha-Pereira, Cristovão Figueiredo, Carmela Piñeiro, Cátia Caldas, Rosário Serrão, António SarmentoAbstractPurposeCD4 cell-count has been regarded as the key surrogate marker for prognostic staging and therapeutic monitoring of HIV-infected individuals. Our purpose was to assess the probability of maintaining a CD4 count>200 cells/μL in patients with continuous viral suppression and CD4 cell counts>200 cells/μL.MethodsRetrosp...
Source: Journal of Microbiology, Immunology and Infection - October 4, 2018 Category: Microbiology Source Type: research

Risk factors for and molecular characteristics of methicillin-resistant Staphylococcus aureus nasal colonization among healthy children in southern Taiwan, 2005–2010
ConclusionsBetween 2005 and 2010, 27.8% and 8.14% of healthy children in southern Taiwan had nasal carriage of S. aureus and MRSA, respectively. Most MRSA isolates were local community strains. Several demographic factors associated with nasal MRSA colonization were identified. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - September 21, 2018 Category: Microbiology Source Type: research

Comparisons of clinical features and outcomes between Elizabethkingia meningoseptica and other glucose non-fermenting Gram-negative bacilli bacteremia in adult ICU patients
Publication date: Available online 19 September 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Wei-Chih Chen, Yen-Wen Chen, Hsin-Kuo Ko, Wen-Kuang Yu, Kuang-Yao YangAbstractBackgroundClinical information of Elizabethkingia meningoseptica (EM) bacteremia in intensive care unit (ICU) patients is limited and the impact on outcomes uncertain. The aim of this study was to investigate the clinical features and impact of EM bacteremia compared to other glucose non-fermenting Gram-negative bacilli (GNF-GNB) bacteremia in ICU patients.MethodsThis retrospective cohort study enrolled 70 patients who developed...
Source: Journal of Microbiology, Immunology and Infection - September 20, 2018 Category: Microbiology Source Type: research

Increased Age and Proton Pump Inhibitors are Associated with Severe Clostridium difficile Infections in Children
Publication date: Available online 20 September 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Tu-Hsuan Chang, Wei-Yun Hsu, Tzu-I. Yang, Chun-Yi Lu, Po-Ren Hsueh, Jong-Min Chen, Ping-Ing Lee, Li-Min Huang, Luan-Yin ChangAbstractBackgroundClostridium difficile infection (CDI) is increasing in children. We aimed to compare the clinical characteristics between CDI and colonization and to identify the risk factors for severe diseases of CDI in children.MethodWe retrospectively reviewed 124 children (1-18 years old) from 2011 to 2018. CDI was defined as diarrhea (≥3 loose stool in the past 24 hours) ...
Source: Journal of Microbiology, Immunology and Infection - September 20, 2018 Category: Microbiology Source Type: research

Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus among nasal carriage strains isolated from emergency department patients and healthcare workers in central Taiwan
ConclusionOverall, a substantial proportion of patients visiting the ED and HCWs harbored CA-MRSA, mostly ST59 strains, in their nares. It is noteworthy that MRSA ST45 strains supplanted ST239 as the second leading nasal MRSA colonization strain in our study. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - September 15, 2018 Category: Microbiology Source Type: research

Protective effect of N-acetylcysteine in prosthetic joint infection: A nationwide population-based cohort study
ConclusionsHigh cumulative dose of N-acetylcysteine (>360 cumulative defined daily dose) can effectively reduce the risk of prosthetic joint infection in patients undergoing knee or hip joint replacement surgery within 5 years. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - September 13, 2018 Category: Microbiology Source Type: research

The diagnostic value of serological studies in pediatric patients with acute Mycoplasma pneumoniae infection
ConclusionsIn the pediatric population, combined serological tests of M. pneumoniae IgA and IgM, offer an accurate method of early diagnosis comparable to that of PCR, and can be an alternative choice for prompt detection of mycoplasma infections when PCR and culture are not available. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - September 13, 2018 Category: Microbiology Source Type: research

Vancomycin-resistant Enterococcus faecium at a university hospital in Taiwan, 2002–2015: Fluctuation of genetic populations and emergence of a new structure type of the Tn1546-like element
ConclusionDissemination of some major STs and horizontal transfer of plasmids carrying two major structure types of Tn1546-like elements may have together contributed to the increase of VRE-fm infection. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - September 8, 2018 Category: Microbiology Source Type: research

Microbiological features, clinical characteristics and outcomes of infective endocarditis in adults with and without hemodialysis: a 10-year retrospective study in Northern Taiwan
Publication date: Available online 5 September 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chien-Yao Wang, Yung-Chih Wang, Ya-Sung Yang, Chan-Yuan Chang, Kuan-Yu Chen, Jiun-Ji Lai, Jung-Chung Lin, Feng-Yee ChangAbstractBackground/Purpose(s)Infective endocarditis (IE) is an important cause of morbidity and mortality in hemodialysis (HD) patients. Data on the differences in the microbiological features as well as clinical characteristics and outcomes of HD and non-HD patients with IE are limited.MethodsMedical records of patients (aged over 20 years) with IE were retrospectively reviewed from Janu...
Source: Journal of Microbiology, Immunology and Infection - September 7, 2018 Category: Microbiology Source Type: research

Impact of Prior Pulmonary Tuberculosis in Treatment Outcomes of HCAP and CAP Patients in Intensive Care Units
ConclusionHistory of prior PTB is an independent clinical factor for increased 30-day mortality rate in ICU-admitted CAP patients, but not in ICU-admitted HCAP patients. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - September 7, 2018 Category: Microbiology Source Type: research