Evaluation of cost-effectiveness of peginterferon plus ribavirin for chronic hepatitis C treatment and direct-acting antiviral agents among HIV-infected patients in the prison and community settings.
Abstract BACKGROUND: In Taiwan, the majority of chronic hepatitis C carriers with HIV co-infection are intravenous drug users and inmates in correctional facilities. Peginterferon and ribavirin (PegIFN/RBV) have been the standard-of-care for chronic hepatitis C virus (HCV) infection more than decades. We evaluated the estimated cost-effectiveness of PegIFN/RBV from the National Health Insurance Research Database, covering the population of Taiwan from 1998 to 2013. MATERIALS AND METHODS: This is an observational study, and study during was 2010-2016 and a total of 239 patients were treated with PegIFN/RBV. Of...
Source: Journal of Microbiology, Immunology, and Infection - October 12, 2018 Category: Microbiology Authors: Chen CP, Cheng CY, Zou H, Cheng CH, Cheng SH, Chen CK, Chen CH, Bair MJ Tags: J Microbiol Immunol Infect Source Type: research

Evaluation of ompK36 allele groups on clinical characteristics and virulence features of Klebsiella pneumoniae from bacteremia.
CONCLUSION: Our results suggest that the OmpK36 group C K.pneumoniae is more associated with community-acquired infection with a lower frequency of underlying illness, but with significantly more virulence in bloodstream infection. This would give a remind that clinicians should be aware of such clinical impacts of the ompK36 allele group. PMID: 30348614 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - October 9, 2018 Category: Microbiology Authors: Du F, Wei DD, Wan LG, Cao XW, Zhang W, Liu Y Tags: J Microbiol Immunol Infect Source Type: research

Mycoplasma pneumoniae in pediatric patients: Do macrolide-resistance and/or delayed treatment matter?
Abstract BACKGROUND: Mycoplasma pneumoniae is a common pathogen for pneumonia in children, especially in the post-pneumococcal conjugate vaccination era. Though self-limited disease was found in the majority of the patients, severe diseases occurred occasionally. The emergence of macrolide resistance was reported worldwide. It is important to delineate whether macrolide resistance or delayed treatment affects outcome. METHODS: We retrospectively collected pediatric patients with M. pneumoniae infection confirmed by positive PCR in a tertiary medical center in Taiwan from 2010 to 2017. Patients' clinical chara...
Source: Journal of Microbiology, Immunology, and Infection - October 9, 2018 Category: Microbiology Authors: Yang TI, Chang TH, Lu CY, Chen JM, Lee PI, Huang LM, Chang LY Tags: J Microbiol Immunol Infect Source Type: research

Implementation of a national quality improvement program to enhance hand hygiene in nursing homes in Taiwan.
CONCLUSIONS: A national quality-improvement program using WHO's hand-hygiene strategy to enhance hand hygiene and reduce healthcare associated infection is effective in nursing homes in Taiwan. PMID: 30316727 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 28, 2018 Category: Microbiology Authors: Lai CC, Lu MC, Tang HJ, Chen YH, Wu YH, Chiang HT, Wu LH, Ko WC, Hsueh PR, Chen YH, for Infection Control Society of Taiwan Tags: J Microbiol Immunol Infect Source Type: research

Real-world effectiveness of direct-acting antiviral agents for chronic hepatitis C in Taiwan: Real-world data.
Abstract BACKGROUND/PURPOSE: Treatment of chronic hepatitis C (CHC) has entered a new era since the introduction of direct-acting antiviral agents (DAAs). Numerous clinical trials have shown that treatment response as well as tolerability of DAAs are superior to those of conventional therapy with pegylated interferon and ribavirin. However, the results of clinical trials may not be directly applied to real-world practice. Therefore our study tried to investigate the effectiveness of various DAA regimens in Taiwanese patients with chronic hepatitis C. METHODS: We performed a retrospective study on 400 CHC pati...
Source: Journal of Microbiology, Immunology, and Infection - September 26, 2018 Category: Microbiology Authors: Hong CM, Liu CH, Su TH, Yang HC, Chen PJ, Chen YW, Kao JH, Liu CJ Tags: J Microbiol Immunol Infect Source Type: research

Concurrent Campylobacter jejuni bacteremia and intussusception in an immunocompetent five-year-old child.
Abstract Bacterial enteritis has been reported to be a risk factor for childhood intussusception. However, no case report concerning children with concurrent Campylobactor bacteremia and intussusception were found in the literature. Herein, we report a 5-year-old male preschool child who presented symptoms of infectious diarrhea, and ileocecal type intussuscepton and Campylobactor jejuni bacteremia were found after a series of investigations. PMID: 30293925 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 24, 2018 Category: Microbiology Authors: Wu PW, Wang CC Tags: J Microbiol Immunol Infect Source Type: research

Monitoring early developed low bone mineral density in HIV-infected patients by intact parathyroid hormone and circulating fibroblast growth factor 23.
CONCLUSIONS: This cohort-based survey showed a high prevalence of low BMD among HIV-infected adults which included young-age patient in an university hospital. Secondary hyperparathyroidism was significantly associated with low BMD. There was no association between FGF23 and low BMD. PMID: 30293926 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 22, 2018 Category: Microbiology Authors: Chen KY, Wang CH, Lin TY, Chang CY, Liu CL, Hsiao YC, Hung CC, Wang NC Tags: J Microbiol Immunol Infect Source Type: research

Increased age and proton pump inhibitors are associated with severe Clostridium difficile infections in children.
Abstract BACKGROUND: Clostridium difficile infection (CDI) is increasing in children. We aimed to compare the clinical characteristics between CDI and colonization and to identify the risk factors for severe diseases of CDI in children. METHOD: We retrospectively reviewed 124 children (1-18 years old) from 2011 to 2018. CDI was defined as diarrhea (≥3 loose stool in the past 24 h) with confirmed toxigenic strain. Colonization was defined as presence of C. difficile without clinical symptoms. Severe diseases included ileus, acute kidney injury, gastrointestinal bleeding or mortality. Patients younger t...
Source: Journal of Microbiology, Immunology, and Infection - September 20, 2018 Category: Microbiology Authors: Chang TH, Hsu WY, Yang TI, Lu CY, Hsueh PR, Chen JM, Lee PI, Huang LM, Chang LY Tags: J Microbiol Immunol Infect Source Type: research

Risk factors for and molecular characteristics of methicillin-resistant Staphylococcus aureus nasal colonization among healthy children in southern Taiwan, 2005-2010.
CONCLUSIONS: Between 2005 and 2010, 27.8% and 8.14% of healthy children in southern Taiwan had nasal carriage of S. aureus and MRSA, respectively. Most MRSA isolates were local community strains. Several demographic factors associated with nasal MRSA colonization were identified. PMID: 30274893 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 20, 2018 Category: Microbiology Authors: Chen CH, Kuo KC, Hwang KP, Lin TY, Huang YC Tags: J Microbiol Immunol Infect Source Type: research

Comparisons of clinical features and outcomes between Elizabethkingia meningoseptica and other glucose non-fermenting Gram-negative bacilli bacteremia in adult ICU patients.
Abstract BACKGROUND: Clinical information of Elizabethkingia meningoseptica (EM) bacteremia in intensive care unit (ICU) patients is limited and the impact on outcomes uncertain. The aim of this study was to investigate the clinical features and impact of EM bacteremia compared to other glucose non-fermenting Gram-negative bacilli (GNF-GNB) bacteremia in ICU patients. METHODS: This retrospective cohort study enrolled 70 patients who developed GNF-GNB bacteremia after ICU admission, including 19 cases of EM bacteremia (19/70, 27.1%). The main outcome measure was in-hospital mortality. RESULTS: The patient...
Source: Journal of Microbiology, Immunology, and Infection - September 19, 2018 Category: Microbiology Authors: Chen WC, Chen YW, Ko HK, Yu WK, Yang KY Tags: J Microbiol Immunol Infect Source Type: research

The diagnostic value of serological studies in pediatric patients with acute Mycoplasma pneumoniae infection.
CONCLUSIONS: In the pediatric population, combined serological tests of M. pneumoniae IgA and IgM, offer an accurate method of early diagnosis comparable to that of PCR, and can be an alternative choice for prompt detection of mycoplasma infections when PCR and culture are not available. PMID: 30266544 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 12, 2018 Category: Microbiology Authors: Lin LJ, Chang FC, Chi H, Jim WT, Tsung-Ning Huang D, Kung YH, Huang CY, Chiu NC, Chang L Tags: J Microbiol Immunol Infect Source Type: research

Protective effect of N-acetylcysteine in prosthetic joint infection: A nationwide population-based cohort study.
CONCLUSIONS: High cumulative dose of N-acetylcysteine (>360 cumulative defined daily dose) can effectively reduce the risk of prosthetic joint infection in patients undergoing knee or hip joint replacement surgery within 5 years. PMID: 30253996 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 12, 2018 Category: Microbiology Authors: Chang CY, Chien WC, Chung CH, Tsao CH, Lin FH, Chang FY, Shang ST, Wang YC Tags: J Microbiol Immunol Infect Source Type: research

Impact of prior pulmonary tuberculosis in treatment outcomes of HCAP and CAP patients in intensive care units.
CONCLUSION: History of prior PTB is an independent clinical factor for increased 30-day mortality rate in ICU-admitted CAP patients, but not in ICU-admitted HCAP patients. PMID: 30245205 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - September 5, 2018 Category: Microbiology Authors: Lin FM, Feng JY, Fang WF, Wu CL, Yu CJ, Lin MC, Ku SC, Chen CW, Tu CY, Yang KY Tags: J Microbiol Immunol Infect Source Type: research

Microbiological features, clinical characteristics and outcomes of infective endocarditis in adults with and without hemodialysis: A 10-year retrospective study in Northern Taiwan.
Abstract BACKGROUND/PURPOSES: Infective endocarditis (IE) is an important cause of morbidity and mortality in hemodialysis (HD) patients. Data on the differences in the microbiological features as well as clinical characteristics and outcomes of HD and non-HD patients with IE are limited. METHODS: Medical records of patients (aged over 20 years) with IE were retrospectively reviewed from January 2008 to June 2017 in a tertiary care center in Northern Taiwan. Those with definite or possible IE were included in the study. The clinical characteristics, microbiological results, echocardiographic findings and outc...
Source: Journal of Microbiology, Immunology, and Infection - September 5, 2018 Category: Microbiology Authors: Wang CY, Wang YC, Yang YS, Chang CY, Chen KY, Lai JJ, Lin JC, Chang FY Tags: J Microbiol Immunol Infect Source Type: research

The incidence rate, trend and microbiological aetiology of prosthetic joint infection after total knee arthroplasty: A 13 years' experience from a tertiary medical center in Taiwan.
Abstract BACKGROUND/PURPOSE: Total knee arthroplasty (TKA) improves the patient's quality of life by relieving pain, correcting the deformity, and helping the patient resume normal activities. However, post-TKA prosthetic joint infection leads to implant failure, is difficult to treat, and causes a significant burden both economically and health-wise. Therefore, an understanding of the current trends in this infection and microbiology data is essential for preventing and treating it. METHODS: A retrospective study was conducted on 10,768 patients who underwent primary TKA at Taipei Veterans General Hospital, ...
Source: Journal of Microbiology, Immunology, and Infection - September 5, 2018 Category: Microbiology Authors: Wang YP, Chen CF, Chen HP, Wang FD Tags: J Microbiol Immunol Infect Source Type: research

Fast track SSTI management program based on a rapid molecular test (GeneXpert ® MRSA/SA SSTI) and antimicrobial stewardship.
CONCLUSION: This type of program could help adjust antibiotic treatment when inappropriate, reducing antibiotic use and costs, length of stay, CDI and related mortality. PMID: 30224283 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 31, 2018 Category: Microbiology Authors: Bouza E, Onori R, Semiglia-Chong MA, Álvarez-Uría A, Alcalá L, Burillo A Tags: J Microbiol Immunol Infect Source Type: research

Adenovirus replication and host innate response in primary human airway epithelial cells.
CONCLUSION: During the infections of hAECs by adenovirus, higher viral replication was found in the apical compartment but cytokine and chemokine responses were higher in the basolateral compartment. This indicated viral entrance and replication occurred more in the apical part and major innate response took place in the basolateral part, which may make adenovirus infect human airway efficiently and cause different degree of severity. PMID: 30217569 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 31, 2018 Category: Microbiology Authors: Yang TI, Li WL, Chang TH, Lu CY, Chen JM, Lee PI, Huang LM, Chang LY Tags: J Microbiol Immunol Infect Source Type: research

Molecular epidemiology and clinical features of rhinovirus infections among hospitalized patients in a medical center in Taiwan.
CONCLUSIONS: HRV was a common cause of respiratory tract infection in Taiwan, particularly in pediatric patients. Eighty percent of HRV-infected inpatients had other microorganisms co-infection. Adult patients were more likely to be associated with a severe respiratory disease entity. PMID: 30201131 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 30, 2018 Category: Microbiology Authors: Hung HM, Yang SL, Chen CJ, Chiu CH, Kuo CY, Huang KA, Lin TY, Hsieh YC, Gong YN, Tsao KC, Huang YC Tags: J Microbiol Immunol Infect Source Type: research

Vancomycin-resistant Enterococcus faecium at a university hospital in Taiwan, 2002-2015: Fluctuation of genetic populations and emergence of a new structure type of the Tn1546-like element.
CONCLUSION: Dissemination of some major STs and horizontal transfer of plasmids carrying two major structure types of Tn1546-like elements may have together contributed to the increase of VRE-fm infection. PMID: 30201132 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 27, 2018 Category: Microbiology Authors: Kuo AJ, Shu JC, Liu TP, Lu JJ, Lee MH, Wu TS, Su LH, Wu TL Tags: J Microbiol Immunol Infect Source Type: research

Molecular epidemiology of the emerging ceftriaxone resistant non-typhoidal Salmonella in southern Taiwan.
CONCLUSION: Though clonal spread of ceftriaxone resistant NTS was suggested by PFGE and MLST, plasmid characterization and beta-lactamase detection revealed their plasmid types and beta-lactamase types were different. PMID: 30201133 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 27, 2018 Category: Microbiology Authors: Chen CY, Hsieh PH, Chang CY, Yang ST, Chen YH, Chang K, Lu PL Tags: J Microbiol Immunol Infect Source Type: research

M2 macrophage subset decrement is an indicator of bleeding tendency in pediatric dengue disease.
CONCLUSION: Decreased the percentages of M2 macrophage subsets in pediatric dengue patients are associated with bleeding tendency and lower platelet counts. PMID: 30196007 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 27, 2018 Category: Microbiology Authors: Lee MS, Tseng YH, Chen YC, Kuo CH, Wang SL, Lin MH, Huang YF, Wang YW, Lin YC, Hung CH Tags: J Microbiol Immunol Infect Source Type: research

Enterobius vermicularis infection mimicking strongyloidiasis: A case report.
PMID: 30190233 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 25, 2018 Category: Microbiology Authors: Chou YH, Chiang SC, Wei PF, Chen SS, Lin KY, Hung CC Tags: J Microbiol Immunol Infect Source Type: research

C-reactive protein levels can predict positive 18F-FDG PET/CT findings that lead to management changes in patients with bacteremia.
We examined 102 patients with bacteremia who had undergone 18F-FDG PET/CT imaging. The patients' clinical and laboratory data were reviewed and analyzed in relation to 18F-FDG PET/CT findings. Patients showing positive results underwent quantitative measurements of 18F-FDG uptake. RESULTS: Positive 18F-FDG PET/CT findings were identified in 74 (72.5%) patients, and 40 (54.1%) underwent modified treatment or management because of the imaging results (p = 0.003). Positive 18F-FDG PET/CT findings were significantly associated with higher white blood cell (WBC) counts and C-reactive protein (CRP) levels (p ...
Source: Journal of Microbiology, Immunology, and Infection - August 23, 2018 Category: Microbiology Authors: Tsai HY, Lee MH, Wan CH, Yang LY, Yen TC, Tseng JR Tags: J Microbiol Immunol Infect Source Type: research

Methicillin-resistant Staphylococcus aureus nasal carriage in international medical conference attendees.
Abstract BACKGROUND: Carriage of methicillin-resistant Staphylococcus aureus (MRSA) is associated with its transmission. International travels and massive gatherings may accelerate such transmission. MRSA carriage was surveyed among the attendees of two international medical conferences held in Taipei in 2010. METHODS: A total of 209 attendees from 23 countries were recruited. Nasal specimens were collected from each volunteer and subjected to polymerase chain reaction (PCR) detection for MRSA. Molecular analysis, including pulsed-field gel electrophoresis, multilocus sequence typing (MLST), typing of staphyl...
Source: Journal of Microbiology, Immunology, and Infection - August 23, 2018 Category: Microbiology Authors: Huang YC, Su LH, Wu TL, Lin TY Tags: J Microbiol Immunol Infect Source Type: research

Associations between environmental heavy metal exposure and childhood asthma: A population-based study.
CONCLUSION: Higher concentrations of blood lead are associated with higher odds of asthma in children aged 2-15 years. PMID: 30177433 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 22, 2018 Category: Microbiology Authors: Wu KG, Chang CY, Yen CY, Lai CC Tags: J Microbiol Immunol Infect Source Type: research

Molecular epidemiology and clinical features of adenovirus infection in Taiwanese children, 2014.
Abstract BACKGROUND/PURPOSES: Human adenovirus (HAdV) infection is prevalent and has an important clinical impact on children. We aim to investigate the molecular epidemiology of HAdV infection and discover the correlations between clinical features and HAdV species in an HAdV outbreak of 2014. METHODS: This is a retrospective study, enrolling patients under 19 years of age with HAdV infection at the National Taiwan University Hospital in 2014. We gathered the demographic and clinical data, carried out molecular typing and constructed a phylogenetic tree. Statistical analyses were performed in terms of HAdV s...
Source: Journal of Microbiology, Immunology, and Infection - August 18, 2018 Category: Microbiology Authors: Lin GL, Lu CY, Chen JM, Lee PI, Ho SY, Weng KC, Huang LM, Chang LY Tags: J Microbiol Immunol Infect Source Type: research

Clinical features, outcomes, and molecular characteristics of an outbreak of Staphylococcus haemolyticus infection, among a mass-burn casualty patient group, in a tertiary center in northern Taiwan.
CONCLUSION: A dominant PFGE type of SH infection was found in these mass-burn casualty patients. Pathogenesis or virulence factors may have contributed to our results. Further study of isolated SH should be conducted. PMID: 30166249 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 18, 2018 Category: Microbiology Authors: Chang PH, Liu TP, Huang PY, Lin SY, Lin JF, Yeh CF, Chang SC, Wu TS, Lu JJ Tags: J Microbiol Immunol Infect Source Type: research

Clinical spectrum of intra-abdominal abscesses in children admitted to the pediatric emergency department.
Abstract BACKGROUND: To analyze clinical spectrum of intra-abdominal abscesses in children and find helpful clinical parameters could aid physicians in earlier detection and differential diagnosis. METHODS: From 2004 to 2011, we retrospectively analyzed 66 pediatric patients, aged 18 years or younger with intra-abdominal abscesses. The data were obtained and studied: demographics, clinical presentations, etiologies, laboratory tests, microbiology, imaging studies, treatment modalities, complications and long-term outcomes. RESULTS: There were 66 patients (mean age, 9.27 ± 4.16 years) dia...
Source: Journal of Microbiology, Immunology, and Infection - August 9, 2018 Category: Microbiology Authors: Chen CY, Lin MJ, Yang WC, Chang YJ, Gao FX, Wu HP Tags: J Microbiol Immunol Infect Source Type: research

Respiratory tract infections in children with tracheostomy.
CONCLUSION: In this study, CP and GERD were associated with infections in children with tracheostomy. Bacterial and non-bacterial pneumonia are difficult to differentiate clinically which may lead to unnecessary antibiotics use. PMID: 30131258 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 9, 2018 Category: Microbiology Authors: Tan CY, Chiu NC, Lee KS, Chi H, Huang FY, Huang DT, Chang L, Kung YH, Huang CY Tags: J Microbiol Immunol Infect Source Type: research

Mycobacterial infections in adult recipients of allogeneic hematopoietic stem cell transplantation: A cohort study in a high endemic area.
CONCLUSION: Mycobacterial infections are worth to note in a high endemic area. Once a high-risk group is identified, much effort is required to target new approaches for prevention, early detection and treatment of infections. PMID: 30082145 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - July 26, 2018 Category: Microbiology Authors: Liu YC, Wu CJ, Ko PS, Chien SH, Fan NW, Wang HY, Gau JP, Liu CJ, Hsiao LT, Chiou TJ, Liu CY, Liu JH Tags: J Microbiol Immunol Infect Source Type: research

Significant apoptosis rather autophagy predominates in astrocytes caused by Toxocara canis larval excretory-secretory antigens.
CONCLUSION: We concluded that TcES Ag may trigger astrocytes apoptosis predominantly through intrinsic and extrinsic pathways rather autophagy, revealing a novel role of astrocytes in the pathogenesis of CT. PMID: 30033092 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - July 11, 2018 Category: Microbiology Authors: Chou CM, Fan CK Tags: J Microbiol Immunol Infect Source Type: research

First identification of Naegleria species and Vahlkampfia ciguana in Nile water, Cairo, Egypt: Seasonal morphology and phylogenetic analysis.
CONCLUSION: Interestingly, there were no seasonal variations in prevalence of Naegleria spp.; yet, there was seasonal diversity in the water samples of the same site. These newly discovered Vahlkampfiidae in Egyptian aquatic environments indicate the need for further phylogenetic investigations using bigger sample sizes in order to determine their potential risk for human health. PMID: 30006270 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - July 3, 2018 Category: Microbiology Authors: El-Badry AA, Aufy SM, El-Wakil ES, Rizk EM, Mahmoud SS, Taha NY Tags: J Microbiol Immunol Infect Source Type: research

Beneficial effects of the commercial lactic acid bacteria product, Vigiis 101, on gastric mucosa and intestinal bacterial flora in rats.
CONCLUSION: The up-regulation of PGE2 and SCFAs in the gastric mucosa is likely to stimulate mucus secretion and increase transmucosal resistance, thereby contributing to Vigiis 101-mediated protection from gastric mucosal lesions induced by pylorus ligation. PMID: 29970350 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 23, 2018 Category: Microbiology Authors: Kao L, Liu TH, Tsai TY, Pan TM Tags: J Microbiol Immunol Infect Source Type: research

Identification and characterization of a Streptococcus suis immunogenic ornithine carbamoytransferase involved in bacterial adherence.
CONCLUSION: In summary, our results suggest that the recombinant SS OCT protein, which is involved in bacterial adherence, may efficiently stimulate an immune response conferring protection against SS infections. It may therefore be considered as a potential vaccine candidate, although further studies are necessary to evaluate their use in swine. PMID: 29934035 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 13, 2018 Category: Microbiology Authors: Wang Y, Yi L, Sun LY, Liu YC, Wen WY, Li XK, Mei JJ, Ding K, Wu TC, Grenier D Tags: J Microbiol Immunol Infect Source Type: research

Liver abscess caused by coexisting Salmonella enteritidis and Entamoeba histolytica in a HIV-infected patient.
PMID: 29921525 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 7, 2018 Category: Microbiology Authors: Lin P, Ko WC, Lin WC, Li MC Tags: J Microbiol Immunol Infect Source Type: research

Methicillin-resistant Staphylococcus aureus nasal carriage and infection among patients with diabetic foot ulcer.
CONCLUSION: Less than one-fifth of patients with DFU have nasal S. aureus, including MRSA, colonization; however, the colonization is significantly associated with S. aureus diabetic foot infection. Screening for S. aureus colonizing status in DFU patients might have a potential clinical implication. PMID: 29907536 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 4, 2018 Category: Microbiology Authors: Lin SY, Lin NY, Huang YY, Hsieh CC, Huang YC Tags: J Microbiol Immunol Infect Source Type: research

Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse  events.
Three months of rifapentine and isoniazid for latent tuberculosis infection in hemodialysis patients: High rates of adverse events. J Microbiol Immunol Infect. 2018 Jun 02;: Authors: Lin SY, Chiu YW, Lu PL, Hwang SJ, Chen TC, Hsieh MH, Chen YH Abstract The consequences of once-weekly rifapentine plus isoniazid for 3 months (3HP) against latent tuberculosis infections in hemodialysis patients have not been studied before. This is the first study to evaluate the safety and tolerability of 3HP in this population and revealed a completion rate of 65.4%. The therapy was not associated with hepatotoxic...
Source: Journal of Microbiology, Immunology, and Infection - June 2, 2018 Category: Microbiology Authors: Lin SY, Chiu YW, Lu PL, Hwang SJ, Chen TC, Hsieh MH, Chen YH Tags: J Microbiol Immunol Infect Source Type: research

First report on Giardia duodenalis assemblage F in Slovakian children living in poor environmental conditions.
CONCLUSION: This study is the first finding of cat specific assemblage F in man not only in Slovakia, but also in Europe. The absence of molecular data about G. duodenalis in companion animals in Slovakia establishes a strong need for further investigation for potential sources of giardiasis and understanding the epidemiology will help to improve the preventive strategies in eradication of infection in this population. PMID: 29907537 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 2, 2018 Category: Microbiology Authors: Pipiková J, Papajová I, Majláthová V, Šoltys J, Bystrianska J, Schusterová I, Vargová V Tags: J Microbiol Immunol Infect Source Type: research

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection during pregnancy: Report of two cases & review of the literature.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection during pregnancy: Report of two cases & review of the literature. J Microbiol Immunol Infect. 2018 Jun 02;: Authors: Alfaraj SH, Al-Tawfiq JA, Memish ZA PMID: 29907538 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - June 2, 2018 Category: Microbiology Authors: Alfaraj SH, Al-Tawfiq JA, Memish ZA Tags: J Microbiol Immunol Infect Source Type: research

Serum trough level as a postmarketing quality measure of generic vancomycin products.
Abstract BACKGROUND: The vancomycin trough level (VTL) is the most widely used pharmacokinetic parameter for monitoring its clinical efficacy. Whether the VTL is affected in patients receiving different vancomycin products has not previously been determined. METHODS: From 2005 to 2015, five vancomycin products, including the innovator (designated as VAN-Lilly) and four generic versions (designated as VAN-A, VAN-B, VAN-C and VAN-D), were sequentially used in a teaching hospital. The initial VTLs were compared between patients who received different vancomycin products after propensity score (PS) weighting and ...
Source: Journal of Microbiology, Immunology, and Infection - June 2, 2018 Category: Microbiology Authors: Tsai YW, Wang YC, Shie SS, Chen MC, Huang YC, Chen CJ Tags: J Microbiol Immunol Infect Source Type: research

Identification of Streptococcus sinensis from a patient with endocarditis using MALDI-TOF mass spectrometry, 16S rDNA- and sodA-based phylogeny.
hant O, Ménard A PMID: 29891358 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 29, 2018 Category: Microbiology Authors: Goret J, Baudinet T, Camou F, Issa N, Gaillard P, Wirth G, Greib C, Barandon L, Mégraud F, Bébéar C, Peuchant O, Ménard A Tags: J Microbiol Immunol Infect Source Type: research

Policy-driven revolution of prescription record in outpatient use of fluoroquinolones.
This study analyzed the claim records of oral FQs prescription at outpatient visits during 2000-2010 using the NHI Research Database and compared prescriptions for narrow-spectrum FQs, which are inactive against Streptococcus pneumoniae and lack formulary restriction, with those for broad-spectrum FQs. RESULTS: Oral antibiotics were prescribed in 13.3% of visits and FQs accounted for 2.2% of them. During the study period the population-based rates of FQ prescription visits to children decreased, which was offset by increased use in the adult and geriatric populations (all p 
Source: Journal of Microbiology, Immunology, and Infection - May 29, 2018 Category: Microbiology Authors: Kuo SC, Shih SM, Lauderdale TY, Chang IS, Chen YC, Hsiung CA, Chang SC Tags: J Microbiol Immunol Infect Source Type: research

Effectiveness of half-a-tablet efavirenz plus 2 nucleos(t)ide reverse-transcriptase inhibitors as maintenance therapy with the guidance of therapeutic drug monitoring among virologically suppressed HIV-positive patients: A prospective study.
Abstract BACKGROUND: Optimal efavirenz (EFV) dose that minimizes adverse effects while maintaining efficacy has yet to be elucidated. With a therapeutic drug monitoring (TDM)-guided strategy, we assessed the effectiveness of half-a-tablet EFV plus 2 nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) in HIV-infected Taiwanese who had achieved viral suppression with full-dose (600 mg) EFV. METHODS: HIV-infected adults receiving EFV-containing regimens who had plasma mid-dose EFV concentration (C12) ≥2.0 mg/L and had plasma HIV RNA load (PVL) 
Source: Journal of Microbiology, Immunology, and Infection - May 29, 2018 Category: Microbiology Authors: Huang SH, Lin SW, Chang SY, Lin YT, Sun HY, Liu WC, Su YC, Hung CC, Chang SC Tags: J Microbiol Immunol Infect Source Type: research

Invasive pneumococcal disease in Indian adults: 11 years' experience.
CONCLUSION: Serotype data from this study helped in accurate estimation of pneumococcal conjugate vaccine-13 and pneumococcal polysaccharide vaccine-23 protective coverage against serotypes causing IPD in India as 58.7% (95% CI: 53.8, 63.4) and 67.4% (95% CI: 62.7, 71.8) respectively. Penicillin non-susceptibility in meningeal IPD cases is 27.4%. Empirical therapy for meningeal IPD must be cephalosporin in combination with vancomycin since cefotaxime non-susceptibility in meningeal IPD is 9.9. PMID: 29884448 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 22, 2018 Category: Microbiology Authors: Jayaraman R, Varghese R, Kumar JL, Neeravi A, Shanmugasundaram D, Ralph R, Thomas K, Veeraraghavan B Tags: J Microbiol Immunol Infect Source Type: research

Two fatal cases of Aeromonas dhakensis bacteremia and necrotizing fasciitis in severe dengue patients.
PMID: 29859782 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 18, 2018 Category: Microbiology Authors: Chang HL, Chen PL, Lin SY, Chen TC, Chang K, Ko WC, Lu PL, Chen YH Tags: J Microbiol Immunol Infect Source Type: research

Antifungal susceptibility of clinical isolates of 25 genetically confirmed Aspergillus species collected from Taiwan and Mainland China.
CONCLUSION: The existence of triazole resistance among A. fumigatus isolates in Taiwan and Mainland China indicates the need for continuous monitoring from now on. PMID: 29844003 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 17, 2018 Category: Microbiology Authors: Li Y, Wang H, Zhao YP, Xu YC, Hsueh PR Tags: J Microbiol Immunol Infect Source Type: research

Candida albicans Aro1 affects cell wall integrity, biofilm formation and virulence.
CONCLUSION: This work provides new insights into C. albicans metabolism, cell wall and virulence. PMID: 29807722 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 17, 2018 Category: Microbiology Authors: Yeh YC, Wang HY, Lan CY Tags: J Microbiol Immunol Infect Source Type: research

Active and passive immunizations with HtsA, a streptococcal heme transporter protein, protect mice from subcutaneous group A Streptococcus infection.
CONCLUSION: The results showed that both active and passive immunization with the HtsA protein protected mice against subcutaneous GAS infection, suggesting that HtsA may be a candidate of GAS vaccine to protect against GAS infection. PMID: 29807723 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 17, 2018 Category: Microbiology Authors: Song Y, Zhang X, Cai M, Lv C, Zhao Y, Wei D, Zhu H Tags: J Microbiol Immunol Infect Source Type: research

Non-typeable Streptococcus pneumoniae infection in a medical center in Taiwan after wide use of pneumococcal conjugate vaccine.
CONCLUSIONS: A gradual increase of NTP infection was found in northern Taiwan in the pneumococcal conjugate vaccine era. Non-typeable pneumococci can cause respiratory and ophthalmological mucosal infection. Invasive infection can occur in newborns or young infants. Most of the isolates remained susceptible to penicillin and ceftriaxone. PMID: 29804657 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - May 14, 2018 Category: Microbiology Authors: Chen HH, Hsu MH, Wu TL, Li HC, Chen CL, Janapatla RP, Su LH, Chiu CH Tags: J Microbiol Immunol Infect Source Type: research

A multicenter study on clinical characteristics of Acinetobacter bacteremia in patients with liver cirrhosis.
Abstract BACKGROUND: Clinical characteristics and risk factors for mortality of Acinetobacter bacteremia in cirrhotic patients have not been investigated. METHODS: Acinetobacter bacteremia cases from four medical centers were collected from 2009 to 2014, to compare between patients with and without liver cirrhosis. Risk factors for mortality of Acinetobacter bacteremia among cirrhotic patients were identified using multivariate logistic regression. RESULTS: Among the patients with Acinetobacter bacteremia, 72 had liver cirrhosis and 816 had not. Patients with cirrhosis were younger (57.5 [50-71] vs. 72 [50.25-71], p 
Source: Journal of Microbiology, Immunology, and Infection - April 25, 2018 Category: Microbiology Authors: Liu CP, Chiang TT, Liu YM, Kuo SC, Yang YS, Lee YT, Chen TL, Shih SC, ACTION Study Group Tags: J Microbiol Immunol Infect Source Type: research