The Role of Regional Disease and Patterns of Treatment Failure in Primary Sinonasal Malignancies
CONCLUSIONS: LN metastases at initial presentation are rare and initial T classification was identified as the most important prognostic factor for OS and CR, emphasizing the need for a thorough initial staging of the primary tumor.PMID:34292084 | DOI:10.1177/19458924211033402 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 22, 2021 Category: ENT & OMF Authors: Christian M Meerwein Panagiotis Balermpas Domenic G Vital Martina A Broglie Michael B Soyka David Holzmann Source Type: research

The Role of Regional Disease and Patterns of Treatment Failure in Primary Sinonasal Malignancies
CONCLUSIONS: LN metastases at initial presentation are rare and initial T classification was identified as the most important prognostic factor for OS and CR, emphasizing the need for a thorough initial staging of the primary tumor.PMID:34292084 | DOI:10.1177/19458924211033402 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 22, 2021 Category: ENT & OMF Authors: Christian M Meerwein Panagiotis Balermpas Domenic G Vital Martina A Broglie Michael B Soyka David Holzmann Source Type: research

Is Body Mass Index Related to Skin Reactivity to Histamine but not to Specific Allergens? A 2-Year Follow-up Study on Korean Children
CONCLUSION: Histamine skin reactivity increased in children over time and some allergens showed increased specific reactions; however, BMI gain is a specific predictor of histamine reactivity. Further studies are needed to elucidate the clinical significance of these changes.PMID:34287086 | DOI:10.1177/19458924211032469 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 21, 2021 Category: ENT & OMF Authors: Michelle J Suh Jin A Park Hyekyung Ko Minji Kang Junhyeong Kim Jiin Lee Jueun Kim Seungjae Baek Keun-Hwa Lee Sung-Chul Hong Ju Wan Kang Source Type: research

Effects of Urban Particulate Matter on the Olfactory System in a Mouse Model
CONCLUSIONS: UPM decreased olfactory function and might have cytotoxic effects on the olfactory epithelium. Olfactory ensheathing cells and trigeminal nerve might be related to the regeneration of the olfactory epithelium after olfactory destruction associated with UPM.PMID:34236242 | DOI:10.1177/19458924211026416 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Boo-Young Kim Ju Y Park Kwang J Cho Jung H Bae Source Type: research

17,18-Epoxyeicosatetraenoic Acid Inhibits TNF- α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
CONCLUSION: These results indicate that 17,18-EpETE plays a regulatory role in mucus hypersecretion and neutrophil infiltration in nasal inflammation. Local or systemic administration may provide a new therapeutic approach for the treatment of intractable airway disease such as CRS.PMID:34236247 | DOI:10.1177/19458924211027682 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Shiori Hara Ichiro Tojima Shino Shimizu Hideaki Kouzaki Takeshi Shimizu Source Type: research

Safety of Endoscopic Sinus Surgery in the Elderly-Are Octogenarian Patients at a Higher Risk?
CONCLUSIONS: Overall, ESS was found to be a safe procedure in elderly patients compared to younger patients. Octogenarian patients should not be denied upfront surgery. IHD is a risk factor for complications in elderly patients.PMID:34236249 | DOI:10.1177/19458924211025374 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Lirit Levi Yonatan Reuven Daniel Ben-Ner Noam Koch Mor Gunders-Peleg Yuval Nachalon Ilan Koren Alain Hazan Gabriel Nakache Ella Reifen Ethan Soudry Source Type: research

Extended Anterior Inferior Approach to Endoscopic Medial Maxillectomy for Maxillary Sinus Lesions
CONCLUSIONS: The EAMM provides improved access to the inferior-posterior-medial maxillary sinus. This approach minimizes the risk of hypoesthesia and change in cosmesis present in other approaches, and obviates division of the nasolacrimal duct for inferior, posterior-medial attached lesions. This progressive escalation of approach for maxillary sinus lesions minimizes injury to nasal and nasolacrimal structures without compromising tumor outcomes.PMID:34236250 | DOI:10.1177/19458924211025371 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Alice E Huang Christopher M Low Janalee K Stokken Source Type: research

Prevalence of Maxillary Sinus Hypoplasia and Silent Sinus Syndrome: A Radiological Cross-Sectional Retrospective Cohort Study
CONCLUSIONS: Our study confirmed the literature data on MSH prevalence, while it determined a precedently unknown prevalence for SSS, underestimated in the radiology reports. This prevalence needs further confirmation but suggests a routine accurate comparison of both maxillary sinuses in CT scans.PMID:34236252 | DOI:10.1177/19458924211029418 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Umberto D'Agostino Fiorenza Chiara Spoldi Liudmila Nekrasova Carlotta Pipolo Paolo Lozza Alberto Scotti Alberto Maccari Giovanni Felisati Alberto Maria Saibene Source Type: research

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study
CONCLUSION: Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.PMID:34236253 | DOI:10.1177/19458924211029428 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Ho Chan Kim Dong-Kyu Kim Ji Sun Kim Ho Jun Lee Mi Rye Bae Woo Ri Choi Yong Ju Jang Source Type: research

Dynamic Changes, Correlation of Basophils, and the Therapeutic Effect in Patients With Allergic Rhinitis During Allergen-specific Immunotherapy
CONCLUSION: The percentage and activation rate of basophils were higher in patients with AR than in controls. The values did not change significantly after allergen-SIT and showed no correlation with treatment effectiveness. Therefore, the frequency and activation rate of basophils cannot be used as criteria for assessing the effectiveness of allergen-SIT for house dust mites. Allergen-SIT is effective for the management of AR, but the effect declines after the completion of therapy.PMID:34236254 | DOI:10.1177/19458924211027073 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Meixu Huo Susu Tang Daihua Wang Xiaoqing Liu Qianxu Liu Source Type: research

Identifying Best Practices for Managing Internal Carotid Artery Injury During Endoscopic Endonasal Surgery by Consensus of Expert Opinion
CONCLUSIONS: There are numerous decisions that a surgeon must make when facing a carotid artery injury. In our estimation, many questions can be grouped under 1 of the 4 categories outlined in our consensus statement and can be addressed by these findings.PMID:34236268 | DOI:10.1177/19458924211024864 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Zachary M Kassir Paul A Gardner Eric W Wang Georgios A Zenonos Carl H Snyderman Source Type: research

Effects of Urban Particulate Matter on the Olfactory System in a Mouse Model
CONCLUSIONS: UPM decreased olfactory function and might have cytotoxic effects on the olfactory epithelium. Olfactory ensheathing cells and trigeminal nerve might be related to the regeneration of the olfactory epithelium after olfactory destruction associated with UPM.PMID:34236242 | DOI:10.1177/19458924211026416 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Boo-Young Kim Ju Y Park Kwang J Cho Jung H Bae Source Type: research

17,18-Epoxyeicosatetraenoic Acid Inhibits TNF- α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
CONCLUSION: These results indicate that 17,18-EpETE plays a regulatory role in mucus hypersecretion and neutrophil infiltration in nasal inflammation. Local or systemic administration may provide a new therapeutic approach for the treatment of intractable airway disease such as CRS.PMID:34236247 | DOI:10.1177/19458924211027682 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Shiori Hara Ichiro Tojima Shino Shimizu Hideaki Kouzaki Takeshi Shimizu Source Type: research

Safety of Endoscopic Sinus Surgery in the Elderly-Are Octogenarian Patients at a Higher Risk?
CONCLUSIONS: Overall, ESS was found to be a safe procedure in elderly patients compared to younger patients. Octogenarian patients should not be denied upfront surgery. IHD is a risk factor for complications in elderly patients.PMID:34236249 | DOI:10.1177/19458924211025374 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Lirit Levi Yonatan Reuven Daniel Ben-Ner Noam Koch Mor Gunders-Peleg Yuval Nachalon Ilan Koren Alain Hazan Gabriel Nakache Ella Reifen Ethan Soudry Source Type: research

Extended Anterior Inferior Approach to Endoscopic Medial Maxillectomy for Maxillary Sinus Lesions
CONCLUSIONS: The EAMM provides improved access to the inferior-posterior-medial maxillary sinus. This approach minimizes the risk of hypoesthesia and change in cosmesis present in other approaches, and obviates division of the nasolacrimal duct for inferior, posterior-medial attached lesions. This progressive escalation of approach for maxillary sinus lesions minimizes injury to nasal and nasolacrimal structures without compromising tumor outcomes.PMID:34236250 | DOI:10.1177/19458924211025371 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Alice E Huang Christopher M Low Janalee K Stokken Source Type: research

Prevalence of Maxillary Sinus Hypoplasia and Silent Sinus Syndrome: A Radiological Cross-Sectional Retrospective Cohort Study
CONCLUSIONS: Our study confirmed the literature data on MSH prevalence, while it determined a precedently unknown prevalence for SSS, underestimated in the radiology reports. This prevalence needs further confirmation but suggests a routine accurate comparison of both maxillary sinuses in CT scans.PMID:34236252 | DOI:10.1177/19458924211029418 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Umberto D'Agostino Fiorenza Chiara Spoldi Liudmila Nekrasova Carlotta Pipolo Paolo Lozza Alberto Scotti Alberto Maccari Giovanni Felisati Alberto Maria Saibene Source Type: research

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study
CONCLUSION: Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.PMID:34236253 | DOI:10.1177/19458924211029428 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Ho Chan Kim Dong-Kyu Kim Ji Sun Kim Ho Jun Lee Mi Rye Bae Woo Ri Choi Yong Ju Jang Source Type: research

Dynamic Changes, Correlation of Basophils, and the Therapeutic Effect in Patients With Allergic Rhinitis During Allergen-specific Immunotherapy
CONCLUSION: The percentage and activation rate of basophils were higher in patients with AR than in controls. The values did not change significantly after allergen-SIT and showed no correlation with treatment effectiveness. Therefore, the frequency and activation rate of basophils cannot be used as criteria for assessing the effectiveness of allergen-SIT for house dust mites. Allergen-SIT is effective for the management of AR, but the effect declines after the completion of therapy.PMID:34236254 | DOI:10.1177/19458924211027073 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Meixu Huo Susu Tang Daihua Wang Xiaoqing Liu Qianxu Liu Source Type: research

Identifying Best Practices for Managing Internal Carotid Artery Injury During Endoscopic Endonasal Surgery by Consensus of Expert Opinion
CONCLUSIONS: There are numerous decisions that a surgeon must make when facing a carotid artery injury. In our estimation, many questions can be grouped under 1 of the 4 categories outlined in our consensus statement and can be addressed by these findings.PMID:34236268 | DOI:10.1177/19458924211024864 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Zachary M Kassir Paul A Gardner Eric W Wang Georgios A Zenonos Carl H Snyderman Source Type: research

Effects of Urban Particulate Matter on the Olfactory System in a Mouse Model
CONCLUSIONS: UPM decreased olfactory function and might have cytotoxic effects on the olfactory epithelium. Olfactory ensheathing cells and trigeminal nerve might be related to the regeneration of the olfactory epithelium after olfactory destruction associated with UPM.PMID:34236242 | DOI:10.1177/19458924211026416 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Boo-Young Kim Ju Y Park Kwang J Cho Jung H Bae Source Type: research

17,18-Epoxyeicosatetraenoic Acid Inhibits TNF- α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
CONCLUSION: These results indicate that 17,18-EpETE plays a regulatory role in mucus hypersecretion and neutrophil infiltration in nasal inflammation. Local or systemic administration may provide a new therapeutic approach for the treatment of intractable airway disease such as CRS.PMID:34236247 | DOI:10.1177/19458924211027682 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Shiori Hara Ichiro Tojima Shino Shimizu Hideaki Kouzaki Takeshi Shimizu Source Type: research

Safety of Endoscopic Sinus Surgery in the Elderly-Are Octogenarian Patients at a Higher Risk?
CONCLUSIONS: Overall, ESS was found to be a safe procedure in elderly patients compared to younger patients. Octogenarian patients should not be denied upfront surgery. IHD is a risk factor for complications in elderly patients.PMID:34236249 | DOI:10.1177/19458924211025374 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Lirit Levi Yonatan Reuven Daniel Ben-Ner Noam Koch Mor Gunders-Peleg Yuval Nachalon Ilan Koren Alain Hazan Gabriel Nakache Ella Reifen Ethan Soudry Source Type: research

Extended Anterior Inferior Approach to Endoscopic Medial Maxillectomy for Maxillary Sinus Lesions
CONCLUSIONS: The EAMM provides improved access to the inferior-posterior-medial maxillary sinus. This approach minimizes the risk of hypoesthesia and change in cosmesis present in other approaches, and obviates division of the nasolacrimal duct for inferior, posterior-medial attached lesions. This progressive escalation of approach for maxillary sinus lesions minimizes injury to nasal and nasolacrimal structures without compromising tumor outcomes.PMID:34236250 | DOI:10.1177/19458924211025371 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Alice E Huang Christopher M Low Janalee K Stokken Source Type: research

Prevalence of Maxillary Sinus Hypoplasia and Silent Sinus Syndrome: A Radiological Cross-Sectional Retrospective Cohort Study
CONCLUSIONS: Our study confirmed the literature data on MSH prevalence, while it determined a precedently unknown prevalence for SSS, underestimated in the radiology reports. This prevalence needs further confirmation but suggests a routine accurate comparison of both maxillary sinuses in CT scans.PMID:34236252 | DOI:10.1177/19458924211029418 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Umberto D'Agostino Fiorenza Chiara Spoldi Liudmila Nekrasova Carlotta Pipolo Paolo Lozza Alberto Scotti Alberto Maccari Giovanni Felisati Alberto Maria Saibene Source Type: research

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study
CONCLUSION: Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.PMID:34236253 | DOI:10.1177/19458924211029428 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Ho Chan Kim Dong-Kyu Kim Ji Sun Kim Ho Jun Lee Mi Rye Bae Woo Ri Choi Yong Ju Jang Source Type: research

Dynamic Changes, Correlation of Basophils, and the Therapeutic Effect in Patients With Allergic Rhinitis During Allergen-specific Immunotherapy
CONCLUSION: The percentage and activation rate of basophils were higher in patients with AR than in controls. The values did not change significantly after allergen-SIT and showed no correlation with treatment effectiveness. Therefore, the frequency and activation rate of basophils cannot be used as criteria for assessing the effectiveness of allergen-SIT for house dust mites. Allergen-SIT is effective for the management of AR, but the effect declines after the completion of therapy.PMID:34236254 | DOI:10.1177/19458924211027073 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Meixu Huo Susu Tang Daihua Wang Xiaoqing Liu Qianxu Liu Source Type: research

Identifying Best Practices for Managing Internal Carotid Artery Injury During Endoscopic Endonasal Surgery by Consensus of Expert Opinion
CONCLUSIONS: There are numerous decisions that a surgeon must make when facing a carotid artery injury. In our estimation, many questions can be grouped under 1 of the 4 categories outlined in our consensus statement and can be addressed by these findings.PMID:34236268 | DOI:10.1177/19458924211024864 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Zachary M Kassir Paul A Gardner Eric W Wang Georgios A Zenonos Carl H Snyderman Source Type: research

Effects of Urban Particulate Matter on the Olfactory System in a Mouse Model
CONCLUSIONS: UPM decreased olfactory function and might have cytotoxic effects on the olfactory epithelium. Olfactory ensheathing cells and trigeminal nerve might be related to the regeneration of the olfactory epithelium after olfactory destruction associated with UPM.PMID:34236242 | DOI:10.1177/19458924211026416 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Boo-Young Kim Ju Y Park Kwang J Cho Jung H Bae Source Type: research

17,18-Epoxyeicosatetraenoic Acid Inhibits TNF- α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
CONCLUSION: These results indicate that 17,18-EpETE plays a regulatory role in mucus hypersecretion and neutrophil infiltration in nasal inflammation. Local or systemic administration may provide a new therapeutic approach for the treatment of intractable airway disease such as CRS.PMID:34236247 | DOI:10.1177/19458924211027682 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Shiori Hara Ichiro Tojima Shino Shimizu Hideaki Kouzaki Takeshi Shimizu Source Type: research

Safety of Endoscopic Sinus Surgery in the Elderly-Are Octogenarian Patients at a Higher Risk?
CONCLUSIONS: Overall, ESS was found to be a safe procedure in elderly patients compared to younger patients. Octogenarian patients should not be denied upfront surgery. IHD is a risk factor for complications in elderly patients.PMID:34236249 | DOI:10.1177/19458924211025374 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Lirit Levi Yonatan Reuven Daniel Ben-Ner Noam Koch Mor Gunders-Peleg Yuval Nachalon Ilan Koren Alain Hazan Gabriel Nakache Ella Reifen Ethan Soudry Source Type: research

Extended Anterior Inferior Approach to Endoscopic Medial Maxillectomy for Maxillary Sinus Lesions
CONCLUSIONS: The EAMM provides improved access to the inferior-posterior-medial maxillary sinus. This approach minimizes the risk of hypoesthesia and change in cosmesis present in other approaches, and obviates division of the nasolacrimal duct for inferior, posterior-medial attached lesions. This progressive escalation of approach for maxillary sinus lesions minimizes injury to nasal and nasolacrimal structures without compromising tumor outcomes.PMID:34236250 | DOI:10.1177/19458924211025371 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Alice E Huang Christopher M Low Janalee K Stokken Source Type: research

Prevalence of Maxillary Sinus Hypoplasia and Silent Sinus Syndrome: A Radiological Cross-Sectional Retrospective Cohort Study
CONCLUSIONS: Our study confirmed the literature data on MSH prevalence, while it determined a precedently unknown prevalence for SSS, underestimated in the radiology reports. This prevalence needs further confirmation but suggests a routine accurate comparison of both maxillary sinuses in CT scans.PMID:34236252 | DOI:10.1177/19458924211029418 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Umberto D'Agostino Fiorenza Chiara Spoldi Liudmila Nekrasova Carlotta Pipolo Paolo Lozza Alberto Scotti Alberto Maccari Giovanni Felisati Alberto Maria Saibene Source Type: research

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study
CONCLUSION: Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.PMID:34236253 | DOI:10.1177/19458924211029428 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Ho Chan Kim Dong-Kyu Kim Ji Sun Kim Ho Jun Lee Mi Rye Bae Woo Ri Choi Yong Ju Jang Source Type: research

Dynamic Changes, Correlation of Basophils, and the Therapeutic Effect in Patients With Allergic Rhinitis During Allergen-specific Immunotherapy
CONCLUSION: The percentage and activation rate of basophils were higher in patients with AR than in controls. The values did not change significantly after allergen-SIT and showed no correlation with treatment effectiveness. Therefore, the frequency and activation rate of basophils cannot be used as criteria for assessing the effectiveness of allergen-SIT for house dust mites. Allergen-SIT is effective for the management of AR, but the effect declines after the completion of therapy.PMID:34236254 | DOI:10.1177/19458924211027073 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Meixu Huo Susu Tang Daihua Wang Xiaoqing Liu Qianxu Liu Source Type: research

Identifying Best Practices for Managing Internal Carotid Artery Injury During Endoscopic Endonasal Surgery by Consensus of Expert Opinion
CONCLUSIONS: There are numerous decisions that a surgeon must make when facing a carotid artery injury. In our estimation, many questions can be grouped under 1 of the 4 categories outlined in our consensus statement and can be addressed by these findings.PMID:34236268 | DOI:10.1177/19458924211024864 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Zachary M Kassir Paul A Gardner Eric W Wang Georgios A Zenonos Carl H Snyderman Source Type: research

Effects of Urban Particulate Matter on the Olfactory System in a Mouse Model
CONCLUSIONS: UPM decreased olfactory function and might have cytotoxic effects on the olfactory epithelium. Olfactory ensheathing cells and trigeminal nerve might be related to the regeneration of the olfactory epithelium after olfactory destruction associated with UPM.PMID:34236242 | DOI:10.1177/19458924211026416 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Boo-Young Kim Ju Y Park Kwang J Cho Jung H Bae Source Type: research

17,18-Epoxyeicosatetraenoic Acid Inhibits TNF- α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
CONCLUSION: These results indicate that 17,18-EpETE plays a regulatory role in mucus hypersecretion and neutrophil infiltration in nasal inflammation. Local or systemic administration may provide a new therapeutic approach for the treatment of intractable airway disease such as CRS.PMID:34236247 | DOI:10.1177/19458924211027682 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Shiori Hara Ichiro Tojima Shino Shimizu Hideaki Kouzaki Takeshi Shimizu Source Type: research

Safety of Endoscopic Sinus Surgery in the Elderly-Are Octogenarian Patients at a Higher Risk?
CONCLUSIONS: Overall, ESS was found to be a safe procedure in elderly patients compared to younger patients. Octogenarian patients should not be denied upfront surgery. IHD is a risk factor for complications in elderly patients.PMID:34236249 | DOI:10.1177/19458924211025374 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Lirit Levi Yonatan Reuven Daniel Ben-Ner Noam Koch Mor Gunders-Peleg Yuval Nachalon Ilan Koren Alain Hazan Gabriel Nakache Ella Reifen Ethan Soudry Source Type: research

Extended Anterior Inferior Approach to Endoscopic Medial Maxillectomy for Maxillary Sinus Lesions
CONCLUSIONS: The EAMM provides improved access to the inferior-posterior-medial maxillary sinus. This approach minimizes the risk of hypoesthesia and change in cosmesis present in other approaches, and obviates division of the nasolacrimal duct for inferior, posterior-medial attached lesions. This progressive escalation of approach for maxillary sinus lesions minimizes injury to nasal and nasolacrimal structures without compromising tumor outcomes.PMID:34236250 | DOI:10.1177/19458924211025371 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Alice E Huang Christopher M Low Janalee K Stokken Source Type: research

Prevalence of Maxillary Sinus Hypoplasia and Silent Sinus Syndrome: A Radiological Cross-Sectional Retrospective Cohort Study
CONCLUSIONS: Our study confirmed the literature data on MSH prevalence, while it determined a precedently unknown prevalence for SSS, underestimated in the radiology reports. This prevalence needs further confirmation but suggests a routine accurate comparison of both maxillary sinuses in CT scans.PMID:34236252 | DOI:10.1177/19458924211029418 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Umberto D'Agostino Fiorenza Chiara Spoldi Liudmila Nekrasova Carlotta Pipolo Paolo Lozza Alberto Scotti Alberto Maccari Giovanni Felisati Alberto Maria Saibene Source Type: research

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study
CONCLUSION: Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.PMID:34236253 | DOI:10.1177/19458924211029428 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Ho Chan Kim Dong-Kyu Kim Ji Sun Kim Ho Jun Lee Mi Rye Bae Woo Ri Choi Yong Ju Jang Source Type: research

Dynamic Changes, Correlation of Basophils, and the Therapeutic Effect in Patients With Allergic Rhinitis During Allergen-specific Immunotherapy
CONCLUSION: The percentage and activation rate of basophils were higher in patients with AR than in controls. The values did not change significantly after allergen-SIT and showed no correlation with treatment effectiveness. Therefore, the frequency and activation rate of basophils cannot be used as criteria for assessing the effectiveness of allergen-SIT for house dust mites. Allergen-SIT is effective for the management of AR, but the effect declines after the completion of therapy.PMID:34236254 | DOI:10.1177/19458924211027073 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Meixu Huo Susu Tang Daihua Wang Xiaoqing Liu Qianxu Liu Source Type: research

Identifying Best Practices for Managing Internal Carotid Artery Injury During Endoscopic Endonasal Surgery by Consensus of Expert Opinion
CONCLUSIONS: There are numerous decisions that a surgeon must make when facing a carotid artery injury. In our estimation, many questions can be grouped under 1 of the 4 categories outlined in our consensus statement and can be addressed by these findings.PMID:34236268 | DOI:10.1177/19458924211024864 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Zachary M Kassir Paul A Gardner Eric W Wang Georgios A Zenonos Carl H Snyderman Source Type: research

Effects of Urban Particulate Matter on the Olfactory System in a Mouse Model
CONCLUSIONS: UPM decreased olfactory function and might have cytotoxic effects on the olfactory epithelium. Olfactory ensheathing cells and trigeminal nerve might be related to the regeneration of the olfactory epithelium after olfactory destruction associated with UPM.PMID:34236242 | DOI:10.1177/19458924211026416 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Boo-Young Kim Ju Y Park Kwang J Cho Jung H Bae Source Type: research

17,18-Epoxyeicosatetraenoic Acid Inhibits TNF- α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
CONCLUSION: These results indicate that 17,18-EpETE plays a regulatory role in mucus hypersecretion and neutrophil infiltration in nasal inflammation. Local or systemic administration may provide a new therapeutic approach for the treatment of intractable airway disease such as CRS.PMID:34236247 | DOI:10.1177/19458924211027682 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Shiori Hara Ichiro Tojima Shino Shimizu Hideaki Kouzaki Takeshi Shimizu Source Type: research

Safety of Endoscopic Sinus Surgery in the Elderly-Are Octogenarian Patients at a Higher Risk?
CONCLUSIONS: Overall, ESS was found to be a safe procedure in elderly patients compared to younger patients. Octogenarian patients should not be denied upfront surgery. IHD is a risk factor for complications in elderly patients.PMID:34236249 | DOI:10.1177/19458924211025374 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Lirit Levi Yonatan Reuven Daniel Ben-Ner Noam Koch Mor Gunders-Peleg Yuval Nachalon Ilan Koren Alain Hazan Gabriel Nakache Ella Reifen Ethan Soudry Source Type: research

Extended Anterior Inferior Approach to Endoscopic Medial Maxillectomy for Maxillary Sinus Lesions
CONCLUSIONS: The EAMM provides improved access to the inferior-posterior-medial maxillary sinus. This approach minimizes the risk of hypoesthesia and change in cosmesis present in other approaches, and obviates division of the nasolacrimal duct for inferior, posterior-medial attached lesions. This progressive escalation of approach for maxillary sinus lesions minimizes injury to nasal and nasolacrimal structures without compromising tumor outcomes.PMID:34236250 | DOI:10.1177/19458924211025371 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Alice E Huang Christopher M Low Janalee K Stokken Source Type: research

Prevalence of Maxillary Sinus Hypoplasia and Silent Sinus Syndrome: A Radiological Cross-Sectional Retrospective Cohort Study
CONCLUSIONS: Our study confirmed the literature data on MSH prevalence, while it determined a precedently unknown prevalence for SSS, underestimated in the radiology reports. This prevalence needs further confirmation but suggests a routine accurate comparison of both maxillary sinuses in CT scans.PMID:34236252 | DOI:10.1177/19458924211029418 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Umberto D'Agostino Fiorenza Chiara Spoldi Liudmila Nekrasova Carlotta Pipolo Paolo Lozza Alberto Scotti Alberto Maccari Giovanni Felisati Alberto Maria Saibene Source Type: research

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study
CONCLUSION: Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.PMID:34236253 | DOI:10.1177/19458924211029428 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Ho Chan Kim Dong-Kyu Kim Ji Sun Kim Ho Jun Lee Mi Rye Bae Woo Ri Choi Yong Ju Jang Source Type: research

Dynamic Changes, Correlation of Basophils, and the Therapeutic Effect in Patients With Allergic Rhinitis During Allergen-specific Immunotherapy
CONCLUSION: The percentage and activation rate of basophils were higher in patients with AR than in controls. The values did not change significantly after allergen-SIT and showed no correlation with treatment effectiveness. Therefore, the frequency and activation rate of basophils cannot be used as criteria for assessing the effectiveness of allergen-SIT for house dust mites. Allergen-SIT is effective for the management of AR, but the effect declines after the completion of therapy.PMID:34236254 | DOI:10.1177/19458924211027073 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 8, 2021 Category: ENT & OMF Authors: Meixu Huo Susu Tang Daihua Wang Xiaoqing Liu Qianxu Liu Source Type: research