Atopy and Quality of Life in Pediatric Chronic Rhinosinusitis.
CONCLUSION: In conclusion, we recommend that testing for aeroallergen sensitivity and assessment of quality of life should be included in the protocol for diagnosis and management of pediatric patients with CRS. Early diagnosis and treatment of allergy may halt the progression of CRS and also the development of asthma and other allergic multimorbid disorders. PMID: 31161768 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - June 4, 2019 Category: ENT & OMF Authors: Anamika A, Chakravarti A, Kumar R Tags: Am J Rhinol Allergy Source Type: research

Psychometric and Clinimetric Validity of the Modified 25-Item Sino-Nasal Outcome Test.
CONCLUSION: The SNOT-25 is a valid instrument that can be used to assess rhinosinusitis disease burden including the impact on productivity and may be a better predictor of treatment decisions and outcomes. PMID: 31134810 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 28, 2019 Category: ENT & OMF Authors: Tait SD, Kallogjeri D, Chidambaram S, Schneider J, Piccirillo JF Tags: Am J Rhinol Allergy Source Type: research

Efficacy of Short-Term Systemic Corticosteroid Therapy in Chronic Rhinosinusitis With Nasal Polyps: A Meta-Analysis of Randomized Controlled Trials and Systematic Review.
Abstract BACKGROUND: Corticosteroids are considered the most effective medication to control chronic rhinosinusitis with nasal polyps (CRSwNP); however, the studies of systemic corticosteroids in this field are relatively few and meta-analyses are lacking. OBJECTIVE: We aimed to systematically review the efficacy and safety of systemic corticosteroids for patients with CRSwNP via meta-analysis. METHODS: Data were extracted from relevant and appropriate randomized controlled trials (RCTs) of systemic corticosteroids for patients with CRSwNP from PubMed, MEDLINE, Ovid, Embase, the Cochrane Central Register...
Source: American Journal of Rhinology and Allergy - May 28, 2019 Category: ENT & OMF Authors: Zhang Y, Wang C, Huang Y, Lou H, Zhang L Tags: Am J Rhinol Allergy Source Type: research

Effect of Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist, on a Rat Model of Acute Bacterial Sinonasal Inflammation.
CONCLUSION: This study histopathologically and molecularly showed that MONT significantly ameliorated the SA-associated sinonasal inflammatory reaction, both alone and in combination with CEFA. These results may suggest that MONT may block the inflammatory reaction underlying RS even more significantly by antioxidative or anti-inflammatory effects. This study suggests MONT as a future potential therapeutic agent for RS treatment. PMID: 31129976 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 27, 2019 Category: ENT & OMF Authors: Kaya Z, Yayla M, Cinar I, Celebi D, Toktay E, Bayraktutan Z, Bilici D Tags: Am J Rhinol Allergy Source Type: research

In-office Placement of Mometasone Furoate Sinus Implants for Recurrent Nasal Polyps: A Pooled Analysis.
Abstract BACKGROUND: A mometasone furoate (MF) sinus implant (1350 mcg) was evaluated in 2 randomized controlled trials (RCTs) in 400 adults with nasal polyps (NP) who were candidates for revision endoscopic sinus surgery (RESS). We conducted a pooled analysis to evaluate the efficacy of MF implant in specific subgroups of NP patients. METHODS: Pooled data from 2 RCTs for 375 patients were analyzed across prespecified subjective and objective end points through day 90. RESULTS: At day 90, patients receiving implants and MF nasal spray (MFNS) experienced significant improvements in nasal obstruction/conge...
Source: American Journal of Rhinology and Allergy - May 23, 2019 Category: ENT & OMF Authors: Stolovitzky JP, Kern RC, Han JK, Forwith KD, Ow RA, Wright SK, Gould A, Matheny KE, Karanfilov B, Huang S, Stambaugh JW, Gawlicka AK Tags: Am J Rhinol Allergy Source Type: research

Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis.
CONCLUSION: Nasal eosinophilia on nasal cytology was a good screening tool for diagnosing LAR because of its high sensitivity and simplicity of the procedure. Unfortunately, the low specificity of nasal eosinophilia makes the NPT necessary for confirmation of LAR. PMID: 31115246 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 22, 2019 Category: ENT & OMF Authors: Phothijindakul N, Chusakul S, Aeumjaturapat S, Snidvongs K, Kanjanaumporn J, Ruangritchankul K, Phannaso C Tags: Am J Rhinol Allergy Source Type: research

Analysis of Absorbable Hemostatic Packing Compared to Physiologic Hemostasis in Functional Endoscopic Sinus Surgery With or Without Septoplasty.
CONCLUSION: This first reported prospective randomized study of patients with nonstrict selection criteria found AHP made no significant difference on subjective and objective postoperative outcomes as compared to physiologic hemostasis. Previous AHP-specific studies have shown differences in carefully selected patient groups. Generalizing study-proved benefits of specific AHP to all AHP is shown to be not appropriate. PMID: 31115256 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 22, 2019 Category: ENT & OMF Authors: Comer BT, Alfonso KP, Doyle EJ, Gallogly JA, Simpson MC, Antisdel JL Tags: Am J Rhinol Allergy Source Type: research

The Distinguishing Clinical Features of Nonallergic Rhinitis Patients.
Abstract BACKGROUND: Not all rhinitis patients are affected by an immunoglobulin E (IgE)-mediated inflammatory process. Skin and serum allergy assessments are limited in their ability to define local allergic rhinitis (LAR). Thus, patients with negative systemic allergy assessments comprise a mix of those who truly have nonallergic rhinitis (NAR) and patients with LAR. OBJECTIVE: To determine the clinical characteristics of patients with NAR. METHODS: A cross-sectional study was performed on consecutive adults with rhinitis symptoms who underwent turbinate surgery. NAR patients were defined by excluding ...
Source: American Journal of Rhinology and Allergy - May 20, 2019 Category: ENT & OMF Authors: Hamizan AW, Azer M, Alvarado R, Earls P, Barham HP, Tattersall J, Rimmer J, Kalish L, Sewell WA, Harvey R Tags: Am J Rhinol Allergy Source Type: research

Impacts of CD40- and CD86-Silenced Antigen-Specific B Cells on the Control of Allergies.
CONCLUSION: This study showed, for the first time, that siRNA-induced CD86-silenced B cells significantly inhibited allergic responses and symptoms antigen-specifically, and that siRNA-induced CD40-/CD86-silenced antigen-specific B cells are a more useful antigen-specific therapy than CD40- or CD86-silenced B cells alone for the control of allergies. Furthermore, it was shown that CD40-/CD86-silenced B cells have stronger inhibition of IgE production and allergic symptoms than CD40-/CD86-silenced DCs. PMID: 31064207 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 8, 2019 Category: ENT & OMF Authors: Suzuki M, Matsumoto T, Toyoda K, Nakamura Y, Murakami S Tags: Am J Rhinol Allergy Source Type: research

Analysis of Histopathological Endotyping for Chronic Rhinosinusitis Phenotypes Based on Comorbid Asthma and Allergic Rhinitis.
The objective of this study is to utilize histopathological markers to better characterize CRS phenotypes that are defined by the presence or absence of comorbid bronchial asthma (BA) and allergic rhinitis (AR). METHODS: A prospective case-controlled study of CRS patients was conducted. For the CRS cohort, mucosal biopsies were obtained during endoscopic sinus surgery, while samples of ethmoid mucosa were collected in control patients undergoing endoscopic skull base surgery. Histopathological analysis of tissue samples determined the relative frequency of inflammatory cell types, including eosinophils, lymphocytes, n...
Source: American Journal of Rhinology and Allergy - May 3, 2019 Category: ENT & OMF Authors: Radabaugh JP, Han JK, Moebus RG, Somers E, Lam K Tags: Am J Rhinol Allergy Source Type: research

Characteristics of Chronic Maxillary Sinusitis in Patients With a History of Long-term Bisphosphonate Use.
CONCLUSIONS: Besides its well-known effects on the mandible, long-term bisphosphonate use can also affect the maxillary sinus, with typical clinical and radiological manifestations. PMID: 31041868 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 1, 2019 Category: ENT & OMF Authors: Hwang CS, Lee C, Chae HS, Han C, Yang HW, Lee YS, Park DJ Tags: Am J Rhinol Allergy Source Type: research

Effect of Intranasal Corticosteroids on Secondary Sinonasal Symptoms: A Systematic Review of Randomized Trials.
CONCLUSIONS: Limited data are available regarding the effectiveness of aqueous or nonaqueous INCS on secondary symptoms in adult patients with rhinitis. Further study is needed using homogenous outcome measures and direct comparison of INCS formulations. PMID: 31035786 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 30, 2019 Category: ENT & OMF Authors: Deot N, Barr J, Mankowski N, Brunner J, McCoul ED Tags: Am J Rhinol Allergy Source Type: research

Leukotriene Receptor Antagonist Addition to H1-Antihistamine Is Effective for Treating Allergic Rhinitis: A Systematic Review and Meta-analysis.
CONCLUSION: For controlling rhinoconjunctivitis symptoms in patients with AR, AH-LTRA provided greater beneficial effects on composite nasal symptoms, rhinorrhea, and sneezing compared to AH alone. These effects were shown in patients with perennial AR. PMID: 31007040 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 22, 2019 Category: ENT & OMF Authors: Seresirikachorn K, Chitsuthipakorn W, Kanjanawasee D, Khattiyawittayakun L, Snidvongs K Tags: Am J Rhinol Allergy Source Type: research

The Role of Relaxin-2 in Tissue Remodeling of Chronic Rhinosinusitis With Nasal Polyps.
Abstract BACKGROUND: Relaxin is a small peptide hormone that regulates extracellular matrix remodeling and reduces fibrosis in a number of organs. Little is known about its impact on chronic rhinosinusitis with nasal polyps (CRSwNP); thus, we aimed to determine the expression of human H2 relaxin (relaxin-2) and its role in tissue remodeling in CRSwNP. METHODS: Patients were enrolled and divided into the following groups: CRS with NP (CRSwNP; n = 20), CRS without NP (CRSsNP; n = 20), and controls (n = 15). Tissue samples were analyzed by Masson trichrome staining for c...
Source: American Journal of Rhinology and Allergy - April 22, 2019 Category: ENT & OMF Authors: Li Y, Tan G, Liu J, Ke X, Shen Y, Huang J, Hu G, Xiang T, Yang Y Tags: Am J Rhinol Allergy Source Type: research

Effect of Acacia Honey on Transforming Growth Factor-Beta-1-Induced Myofibroblast Differentiation and Matrix Metalloproteinase-9 Production in Nasal Polyp Fibroblasts.
CONCLUSION: Acacia honey can inhibit TGF-β1-induced myofibroblast differentiation and MMP-9 production in nasal fibroblasts. These results suggest that acacia honey might be useful for inhibiting nasal polyp formation. PMID: 30997818 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 18, 2019 Category: ENT & OMF Authors: Shin SH, Ye MK, Lee DW, Che MH Tags: Am J Rhinol Allergy Source Type: research

Efficacy of Dexamethasone Versus Fluticasone Nasal Sprays in Postoperative Patients With Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSION: There is no significant increased benefit in using a higher dose nasal steroid spray compared to the standard dose nasal steroid spray after ESS. PMID: 30987428 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 16, 2019 Category: ENT & OMF Authors: Seiberling KA, Kidd SC, Kim GH, Church CA Tags: Am J Rhinol Allergy Source Type: research

Somatization, Depression, and Anxiety Disorders in a Rhinology Practice.
CONCLUSIONS: Patients should be counseled about the pathophysiology and psychiatric comorbidities affecting their primary rhinologic complaints. The provider needs to set realistic treatment expectations in order to achieve the desired clinical outcomes. PMID: 30947506 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 5, 2019 Category: ENT & OMF Authors: Alam ES, Musselman DL, Chyou D, Shukri G, Levine CG, Sanghvi S, Zhang H, Casiano RR Tags: Am J Rhinol Allergy Source Type: research

Surgical Approach to Frontal Sinus Osteoma: A Systematic Review.
Abstract BACKGROUND: Osteoma of the paranasal sinuses are benign bony masses most commonly found in the frontal sinus. In the past, due to the anatomical complexity of the frontal sinus, these often required an open approach, but with the invention of angled tools and endoscopes, many rhinologists are now attempting endoscopic or combined resections. No large systematic reviews currently exist that describe the surgical management of frontal sinus osteoma. OBJECTIVE: To perform a systematic review detailing the surgical resection of frontal sinus osteoma. Review Methods: A systematic literature review was per...
Source: American Journal of Rhinology and Allergy - April 5, 2019 Category: ENT & OMF Authors: Watley DC, Mong ER, Rana NA, Illing EA, Chaaban MR Tags: Am J Rhinol Allergy Source Type: research

Effect of Astragalus membranaceus in Ovalbumin-Induced Allergic Rhinitis Mouse Model.
CONCLUSIONS: AM could reduce the secretion of inflammatory cytokines by increasing the level of CD4+ CD25+ Foxp3+ T cells and inhibiting the activation of the NF-κB. PMID: 30945558 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 4, 2019 Category: ENT & OMF Authors: Bing Z, Jin-Tao D, Feng L, Ba L, Ya-Feng L, Shi-Xi L Tags: Am J Rhinol Allergy Source Type: research

Quality of Life and Impact of Endoscopic Sinus Surgery in Adult Patients With Cystic Fibrosis.
CONCLUSIONS: ESS represents the best option to improve clinical QoL of CF patients who do not response to conventional medical therapy. PMID: 30931587 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 1, 2019 Category: ENT & OMF Authors: Lazio MS, Luparello P, Mannelli G, Santoro GP, Bresci S, Braggion C, Gallo O, Maggiore G Tags: Am J Rhinol Allergy Source Type: research

Asian Sand Dust Regulates IL-32 Production in Airway Epithelial Cells: Inhibitory Effect of Glucocorticoids.
CONCLUSIONS: GCs have an inhibitory effect on ASD-induced IL-32 expression via the Akt, MAPK, and NF- κB signaling pathways in airway epithelial cells. PMID: 30919652 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 28, 2019 Category: ENT & OMF Authors: Shin JM, Kim HJ, Park JH, Hwang YJ, Lee HM Tags: Am J Rhinol Allergy Source Type: research

No Differences in Nasal Tissue Inflammatory Cells and Adhesion Molecules (iCAM-1 and vCAM-1) Based on the Comparison of EGPA With Eosinophilic Chronic Sinusitis With Polyposis.
CONCLUSIONS: We do not have yet blood or tissue markers able to differentiate the early phase of EGPA from chronic rhinosinusitis with nasal polyps. Further investigations are mandatory considering EGPA patients at their initial diagnosis and before any treatment, in terms of nasal histology and blood inflammatory cells, to identify markers characterizing sinonasal mucosa inflammation and useful for an early diagnosis of EGPA. PMID: 30905163 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2019 Category: ENT & OMF Authors: Brescia G, Schiavon F, Nicolè L, Zanoletti E, Zanotti C, Padoan R, Felicetti M, Parrino D, Cinetto F, Cangiano D, Giacomelli L, Cappellesso R, Martini A, Fassina A, Marioni G Tags: Am J Rhinol Allergy Source Type: research

Early Versus Late Computed Tomography and Nasal Endoscopy in the Diagnosis of Nasopharyngeal and Paranasal Sinus Malignancy.
CONCLUSIONS: Early NE or CT is associated with a higher likelihood of cancer diagnosis in elderly individuals with a diagnosis of CRS or AR. The clinical utility of this association is limited due to the low prevalence of these malignancies and lack of difference in disease stage and overall survival between diagnostic groups. PMID: 30900468 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 22, 2019 Category: ENT & OMF Authors: Marino MJ, Hsieh MC, Wu EL, Riley CA, Wu XC, McCoul ED Tags: Am J Rhinol Allergy Source Type: research

A Comprehensive Systematic Review of the Association Between Airway Mucins and Chronic Rhinosinusitis.
CONCLUSION: There is a strong correlation between alterations in mucin expression profiles and CRS. This systematic review highlights the most recent literature on the role of mucins in CRS. The analysis of these studies is limited by the heterogeneity in study designs, relatively few numbers of clinical samples, and lack of mechanistic studies in animal models and in vitro cultures. PMID: 30892914 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 20, 2019 Category: ENT & OMF Authors: Kato K, Song BH, Howe CL, Chang EH Tags: Am J Rhinol Allergy Source Type: research

Expression of IL-25, IL-33, and Thymic Stromal Lymphopoietin in Nasal Polyp Gland Duct Epithelium in Patients With Chronic Rhinosinusitis.
CONCLUSION: Cytokine expression in nasal duct cells and eosinophilic infiltration around duct cells similar to those in the nasal mucosa occurred in the nasal epithelium of polyps, suggesting its role in inducing eosinophilic inflammation. PMID: 30873846 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 15, 2019 Category: ENT & OMF Authors: Nagata Y, Maruoka S, Gon Y, Mizumura K, Kishi H, Nomura Y, Hikichi M, Hashimoto S, Oshima T Tags: Am J Rhinol Allergy Source Type: research

Procalcitonin as a Biomarker in Rhinosinusitis: A Systematic Review.
CONCLUSIONS: The limited existing literature on the role of PCT in diagnosis, management, and prediction of clinical outcomes in ARS suggests that PCT-based guidelines for antibiotic prescription are a safe and effective method of minimizing unnecessary antibiotic use. PMID: 30871341 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2019 Category: ENT & OMF Authors: Dilger AE, Peters AT, Wunderink RG, Tan BK, Kern RC, Conley DB, Welch KC, Holl JL, Smith SS Tags: Am J Rhinol Allergy Source Type: research

Otolaryngology.
PMID: 30871342 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2019 Category: ENT & OMF Authors: Brunner JP, Amedee RG Tags: Am J Rhinol Allergy Source Type: research

Heinz Stammberger 1946-2018.
PMID: 30871343 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2019 Category: ENT & OMF Authors: Kennedy DW Tags: Am J Rhinol Allergy Source Type: research

2018 Reviewer Thank You.
Authors: PMID: 30871344 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2019 Category: ENT & OMF Tags: Am J Rhinol Allergy Source Type: research

The Comparation of Intraperitoneal Injection and Nasal-only Delivery Allergic Rhinitis Model Challenged With Different Allergen Concentration.
CONCLUSION: The IP injection model and the nasal-only delivery model are 2 typical models for AR that causes a different immune response. A positive dose-response relationship in the nasal-only delivery model is observed from 25 mg/mL to 0.025 mg/mL. PMID: 30871345 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 1, 2019 Category: ENT & OMF Authors: Wang Y, Zhou Y, Zhu Y, Yu W, Wang J, Fu J, Yuan Y, Yu Z, Chen S, Wang Y, Chen J, Kong W Tags: Am J Rhinol Allergy Source Type: research

Nasal Symptoms Reduction and Decreased Neutrophilia in Japanese Cedar Pollinosis With Prophylactic Treatment With a Combination of Montelukast, Fexofenadine, and Fluticasone Nasal Spray.
We reported neutrophil-associated tissue damage in cedar pollinosis subjects with refractory nasal symptoms prior to pollinosis season. Because the leukotriene receptor antagonist, montelukast, can inhibit neutrophil recruitment and activation, we investigated its effects on symptom relief and nasal neutrophilia in pollinosis subjects in the preseason. METHODS: In the pollinosis preseason, symptomatic (PreSyP, n = 149) and asymptomatic subjects (PreAsP, n = 145) were prophylactically treated, and in season symptomatic subjects (InSyP, n = 134) were treated. Individuals were as...
Source: American Journal of Rhinology and Allergy - March 1, 2019 Category: ENT & OMF Authors: Otsuka H, Otsuka K, Matsune S, Okubo K Tags: Am J Rhinol Allergy Source Type: research

Tissue and Exosomal Serine Protease Inhibitors Are Significantly Overexpressed in Chronic Rhinosinusitis With Nasal Polyps.
Abstract BACKGROUND: The fibrinolysis pathway has been previously implicated in the etiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). OBJECTIVE: The purpose of this study was (1) to explore protein derangements of selected protease inhibitors of the serpin superfamily in CRSwNP and (2) to correlate the protease inhibitor derangements of the fibrinolysis pathway in tissue with exosomal samples to evaluate the potential of an exosomal noninvasive "liquid biopsy" for CRSwNP. METHODS: Institutional review board approved study in which matched tissue and mucus exosomal proteins ...
Source: American Journal of Rhinology and Allergy - February 27, 2019 Category: ENT & OMF Authors: Mueller SK, Nocera AL, Dillon ST, Libermann TA, Wendler O, Bleier BS Tags: Am J Rhinol Allergy Source Type: research

Decreased Antibiotic Utilization After Sinus Surgery in Cystic Fibrosis Patients With Lung Transplantation.
CONCLUSION: Our results suggest that ESS is associated with a reduction in the frequency of antibiotic utilization for respiratory tract infections in lung transplant recipients with CF. A prospective study is needed to investigate these relationships further. PMID: 30781973 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - February 20, 2019 Category: ENT & OMF Authors: Cheng TZ, Choi KJ, Honeybrook AL, Zakare-Fagbamila RT, Gray AL, Snyder LD, Palmer SM, Abi-Hachem R, Jang DW Tags: Am J Rhinol Allergy Source Type: research

A Radiological Study Assessing the Prevalence of Frontal Recess Cells and the Most Common Frontal Sinus Drainage Pathways.
CONCLUSION: This study documents the prevalence of frontal cells (classified by IFAC) using a novel preoperative virtual planning software in the Vietnamese population. It demonstrates predominantly medial anteromedial frontal drainage pathways as related to these frontal cells. PMID: 30754987 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - February 13, 2019 Category: ENT & OMF Authors: Tran LV, Ngo NH, Psaltis AJ Tags: Am J Rhinol Allergy Source Type: research

Preoperative Management of Chronic Rhinosinusitis Prior to Office Balloon Sinus Dilation: A 2011-2014 MarketScan ® Analysis.
CONCLUSION: In-office BSD for CRS was overall associated with less intense management in the preoperative period when compared to FESS. Such differences may reflect ongoing shifts in practice patterns and need to be further investigated. PMID: 30732455 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - February 7, 2019 Category: ENT & OMF Authors: Jang DW, Abraham C, Cyr DD, Schulz K, Abi Hachem R, Witsell DL Tags: Am J Rhinol Allergy Source Type: research

Effects of Intranasal Cellulose Powder on Asthma Control in Children With Mild-to-Moderate Perennial Allergic Rhinitis: A Randomized, Placebo-Controlled Trial.
Abstract BACKGROUND: Perennial allergic rhinitis (PAR) often coexists in asthmatic patients. Intranasal cellulose powder (ICP) was reportedly effective in ameliorating PAR. OBJECTIVE: We investigated whether ICP is equally effective compared with intranasal corticosteroids in improving asthma control as well as nasal symptoms among children with PAR and allergic asthma (AA). METHODS: Between July 2015 and September 2016, we did a single-center, randomized, placebo-controlled trial. Asthmatic children aged 6 to 11 years with mild-to-moderate PAR were randomly assigned to formoterol/budesonide inhalation (...
Source: American Journal of Rhinology and Allergy - February 1, 2019 Category: ENT & OMF Authors: Chen X, Guan WJ, Sun SX, Zheng PY, Sun LH, Chen DH, Wang DD, Chen C, Sun BQ, Douglas Zhang XH Tags: Am J Rhinol Allergy Source Type: research

Factors Associated With Patient Nonattendance in Rhinology Clinics.
Abstract BACKGROUND: Nonattendance to clinical appointments is a global problem appreciated by clinicians with an ambulatory presence. There are few reports of nonattendance in otolaryngology clinics, and no reports on nonattendance for a single otolaryngology subspecialty. OBJECTIVE: To describe the no-show population in rhinology clinics. METHODS: A retrospective chart review was performed involving rhinology clinics from 2 academic medical centers in the United States. All patients who either attended their clinic appointment(s) or did not attend without previously cancelling from June 2016 to May 201...
Source: American Journal of Rhinology and Allergy - January 29, 2019 Category: ENT & OMF Authors: Hunter BN, Cardon B, Oakley GM, Sharma A, Crosby DL Tags: Am J Rhinol Allergy Source Type: research

Radiographic Nuances in Allergic Fungal Rhinosinusitis.
Abstract BACKGROUND: Allergic fungal rhinosinusitis (AFRS) is characterized by higher revision endoscopic sinus surgery (ESS) rates and unique radiographic features when compared to chronic rhinosinusitis with nasal polyposis (CRSwNP) or chronic rhinosinusitis without nasal polyposis (CRSsNP). OBJECTIVE: We hypothesized that an increased frequency of concha bullosa in AFRS or other radiographic nuances might allow for accumulation of allergic mucin and contribute to increased ESS revision rates. METHODS: A retrospective cohort study was performed. Patient diagnosis (AFRS, CRSwNP, and CRSsNP), basic demog...
Source: American Journal of Rhinology and Allergy - January 24, 2019 Category: ENT & OMF Authors: Rowan NR, Janz TA, Schlosser RJ, Soler ZM Tags: Am J Rhinol Allergy Source Type: research

Head and Bottle Angles Achieved by Patients During High-Volume Sinonasal Irrigations.
CONCLUSION: When instructed to irrigate in the nose-to-floor head position, patients achieved a head position uprotated 20° on lateral view and vertex rotated 10° away from the side of irrigation on frontal view. PMID: 30674198 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 24, 2019 Category: ENT & OMF Authors: Griggs ZH, M Williams A, Craig JR Tags: Am J Rhinol Allergy Source Type: research

Historical Instruments for the Modern Sinus Surgeon.
CONCLUSION: Review of the history of these instruments helps demonstrate how sinus surgery has evolved to where it is today. The men described in this review transformed the practice of rhinologic surgery with their ingenuity and perseverance. PMID: 30672306 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 23, 2019 Category: ENT & OMF Authors: Brody-Camp SA, Weinert DA, McCoul ED Tags: Am J Rhinol Allergy Source Type: research

Turbinate-Specific IgE in Normal and Rhinitic Patients.
CONCLUSION: Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research. PMID: 30656948 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 18, 2019 Category: ENT & OMF Authors: Hamizan AW, Rimmer J, Alvarado R, Sewell WA, Tatersall J, Barham HP, Kalish L, Harvey RJ Tags: Am J Rhinol Allergy Source Type: research

Lund-Mackay Computed Tomography Score Is Associated With Obstructive Pulmonary Function Changes in Chronic Cough Patients.
CONCLUSION: The patients with chronic cough frequently had paranasal sinus abnormalities. The Lund-Mackay CT score may be useful for assessing the condition of the lower airway in chronic cough patients. Upper airway examinations should play a part in the management of chronic cough. PMID: 30656950 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 18, 2019 Category: ENT & OMF Authors: Kariya S, Okano M, Higaki T, Tachibana T, Rikimaru T, Nishizaki K Tags: Am J Rhinol Allergy Source Type: research

Differential Expression of Fas in Moderate/Severe and Mild Persistent Allergic Rhinitis and Its Correlation With Pathological Parameters.
CONCLUSION: According to the results of this study, there might be a relationship between the expression of Fas receptor on nasal turbinate mucosa and the severity of persistent allergic rhinitis. PMID: 30648403 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 16, 2019 Category: ENT & OMF Authors: Pirayesh A, Shahsavan S, Zargari Samani O, Shirzad H, Amani S, Zamani MA, Salimzadeh L, Bageri N, Moghni M, Deris F Tags: Am J Rhinol Allergy Source Type: research

Topical Corticosteroid Pretreatment Mitigates Cellular Damage After Caustic Injury to the Nasal Upper Airway Epithelium.
CONCLUSION: Topical corticosteroid treatment to the nasal epithelium can mitigate several of the early deleterious effects of acute epithelial damage in experimental airway injuries caused by TCA. These findings suggest a novel, direct cytoprotective effect of corticosteroids on the nasal epithelium, and the potential of expanding the use of prophylactic periprocedural topical corticosteroids for respiratory epithelial tissues. PMID: 30638033 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 14, 2019 Category: ENT & OMF Authors: Huang Z, Velasquez N, Nguyen A, Ye T, Le W, Bravo DT, Hwang PH, Zhou B, Nayak JV Tags: Am J Rhinol Allergy Source Type: research

Association Between Olfactory and Gustatory Dysfunction and Cognition in Older Adults.
Abstract BACKGROUND: The association between olfactory dysfunction (OD) and cognitive decline is becoming apparent in the emerging literature. However, the literature demonstrating a similar effect between gustatory dysfunction (GD) and cognition is not well established. OBJECTIVE: To determine whether OD and GD are independently associated with cognitive impairment. METHODS: The 2013-2014 National Health and Nutrition Examination Survey was queried for 1376 older adults, corresponding to a weighted population sample of 50 816 529, to assess olfactory and gustatory status and cognition using univariate a...
Source: American Journal of Rhinology and Allergy - January 11, 2019 Category: ENT & OMF Authors: Churnin I, Qazi J, Fermin CR, Wilson JH, Payne SC, Mattos JL Tags: Am J Rhinol Allergy Source Type: research

Radiation-Induced Rhinitis: Cytological and Olfactory Changes.
CONCLUSIONS: RT for HNC induces acute rhinitis that may persist after the completion of treatment and can affect patient's quality of life. Nasal cytology can help to choose the best treatment on an individual basis. PMID: 30632393 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 11, 2019 Category: ENT & OMF Authors: Riva G, Franco P, Provenzano E, Arcadipane F, Bartoli C, Lava P, Ricardi U, Pecorari G Tags: Am J Rhinol Allergy Source Type: research

The Dangers of Sneezing: A Review of Injuries.
CONCLUSION: A variety of injuries can occur during a sneeze, especially when a closed-airway sneeze is attempted, and high Valsalva pressure is transmitted to the other systems. Men are more at risk for these injuries with the majority occurring in patients with no known risk factor. When triggered, a sneeze should be allowed to proceed without intervention to prevent associated injuries. PMID: 30616365 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 8, 2019 Category: ENT & OMF Authors: Setzen S, Platt M Tags: Am J Rhinol Allergy Source Type: research

Bioinformatics-Based Approaches Predict That MIR-17-5P Functions in the Pathogenesis of Seasonal Allergic Rhinitis Through Regulating ABCA1 and CD69.
CONCLUSION: CPEB4 and CREB might be implicated in the pathogenesis of SAR. Besides, MIR-17-5P might also act in SAR via targeting ABCA1 and CD69. PMID: 30616374 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 8, 2019 Category: ENT & OMF Authors: Liu X, Ren Y, Sun X, Huang H, Liu X Tags: Am J Rhinol Allergy Source Type: research

Open Versus Endoscopic Approach for Sinonasal Melanoma: A Systematic Review and Meta-analysis.
CONCLUSION: Based on the available literature, an endoscopic approach for SNM resection has survival outcomes that are similar or greater compared to an open approach. PMID: 30616359 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - January 7, 2019 Category: ENT & OMF Authors: Hur K, Zhang P, Yu A, Kim-Orden N, Kysh L, Wrobel B Tags: Am J Rhinol Allergy Source Type: research

Biologic Agents for the Treatment of Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSION: These treatments have promising results and may prove to be an important adjunct for patients with recalcitrant sinus disease. PMID: 30587005 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - December 27, 2018 Category: ENT & OMF Authors: Kartush AG, Schumacher JK, Shah R, Patadia MO Tags: Am J Rhinol Allergy Source Type: research