Editorial.
PMID: 33012182 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - October 7, 2020 Category: ENT & OMF Authors: Zhao K Tags: Am J Rhinol Allergy Source Type: research

Impact of COVID-19 Pandemic on Ambulatory and Operating Room Rhinology Practice in the US.
Abstract INTRODUCTION: The pandemic caused by the novel coronavirus virus has altered all facets of clinical practice in the United States. The goal of this study is to better understand the impact of COVID-19 on rhinologic ambulatory and operative practice. METHODS: A 27-item survey to assess these objectives was created and approved by the Division of Rhinology faculty at Rush University Medical Center in April 2020. The survey was then distributed to rhinologists in a web based format via www.surveymonkey.com from April 10 through April 23, 2020. RESULTS: A total of 277 U.S based rhinologists responde...
Source: American Journal of Rhinology and Allergy - October 5, 2020 Category: ENT & OMF Authors: Papagiannopoulos P, Ganti A, Kim YJ, Raad RA, Kuan EC, Losavio P, Tajudeen BA, Batra PS Tags: Am J Rhinol Allergy Source Type: research

Surgery in Nasal Polyp Patients: Outcome After a Minimum Observation of 10 Years.
In this study, we aim to estimate disease recurrence during a long-term follow-up, together with the investigation of possible predicting and/or influencing parameters. METHODS: Out of 196 patients operated for CRSwNP between 01/2000 and 01/2006, 133 patients had a follow-up of at least 10 years and could be included. The inflammatory profile at surgery was determined on nasal tissue and sinonasal secretions, and included analysis of eosinophils, eosinophilic-rich mucus (ERM) typically containing Charcot-Leyden crystals (CLC), and fungal hyphae (FH). During follow-up, recurrence, received treatments and comorbidities ...
Source: American Journal of Rhinology and Allergy - October 5, 2020 Category: ENT & OMF Authors: Vlaminck S, Acke F, Prokopakis E, Speleman K, Kawauchi H, van Cutsem JC, Hellings PW, Jorissen M, Seys S, Bachert C, Zele TV, Lambrecht BN, Gevaert P Tags: Am J Rhinol Allergy Source Type: research

Salvage Endoscopic Nasopharyngectomy in Recurrent Nasopharyngeal Carcinoma: Prognostic Factors and Treatment Outcomes.
This study aimed to investigate the demographics, treatment outcomes, and prognostic factors of salvage endoscopic nasopharyngectomy in recurrent nasopharyngeal carcinoma (NPC). METHODS: We conducted a retrospective analysis of 189 patients who underwent treatment for recurrent NPC from January 2006 to June 2018. The Kaplan-Meier method and log-rank test were used to assess survival rates. A Cox regression model was used for multivariate survival analyses. RESULTS: We included 132 men and 57 women in the study, with a median age of 51 (range, 25-85) years. The overall 1-, 3-, and 5-year survival rates were 82.2%,...
Source: American Journal of Rhinology and Allergy - October 5, 2020 Category: ENT & OMF Authors: Li W, Lu H, Wang H, Zhang H, Sun X, Hu L, Zhao W, Gu Y, Li H, Wang D Tags: Am J Rhinol Allergy Source Type: research

Quantification of Aerosol Particle Concentrations During Endoscopic Sinonasal Surgery in the Operating Room.
CONCLUSION: Drilling and microdebrider use during endonasal surgery in a standard operating room is associated with a significant increase in airborne particle concentrations. Fortunately, this increase in aerosol concentration is localized to the area of the operating surgeon, with no detectable increase in aerosol particles at other OR positions. PMID: 33012174 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - October 4, 2020 Category: ENT & OMF Authors: Murr A, Lenze NR, Brown WC, Gelpi MW, Ebert CS, Senior BA, Thorp BD, Zanation AM, Kimple AJ Tags: Am J Rhinol Allergy Source Type: research

TRPV4-Mediated Epithelial Junction Disruption in Allergic Rhinitis Triggered by House Dust Mites.
CONCLUSIONS: Increased TRPV4 expression occurred in epithelial cells harvested from patients with AR and epithelial cells stimulated by Th2 cytokines. Decreased junctional protein expression in epithelial cells after the stimulation by house dust mite allergen with TRPV4 agonist indicates a possible role of TRPV4 in the pathogenesis of allergen-induced epithelial barrier disruption in AR. PMID: 33012175 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - October 4, 2020 Category: ENT & OMF Authors: Lee K, Byun J, Kim B, Yeon J, Tai J, Lee SH, Kim TH Tags: Am J Rhinol Allergy Source Type: research

Porcine Tracheal Mucosa-Derived Decellularized Patch to Prevent Septal Perforation in a Rabbit Model.
CONCLUSION: Decellularized porcine tracheal mucosa can prevent mucosal defects from progressing to septal perforation, promote the repair of mucosal defects, and protect the nasal cartilage. PMID: 32993316 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 30, 2020 Category: ENT & OMF Authors: Kim SJ, Jung SY, Lee MJ, Bae JH, Kim HS Tags: Am J Rhinol Allergy Source Type: research

Dupilumab as Add-on Therapy for Chronic Rhinosinusitis With Nasal Polyposis in Aspirin Exacerbated Respiratory Disease.
CONCLUSION: Dupilumab was highly effective as add-on therapy for CRSwNP in AERD, improving patient-reported outcomes, sinus opacification, and markers of T2 inflammation. PMID: 32967430 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 23, 2020 Category: ENT & OMF Authors: Mustafa SS, Vadamalai K, Scott B, Ramsey A Tags: Am J Rhinol Allergy Source Type: research

Olfactory Function After Surgical Treatment of CRS: A Comparison of CRS Patients to Healthy Controls.
CONCLUSION: ESS improved olfactory metrics and restored olfactory function in approximately 50% of patients with CRS to that of healthy controls. Concurrent septoplasty increased the likelihood of achieving normal olfaction, while NP and previous ESS decreased those odds. PMID: 32954837 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 20, 2020 Category: ENT & OMF Authors: Mattos JL, Soler ZM, Schlosser RJ, Mace JC, Alt JA, Ramakrishnan VR, Payne SC, Smith TL, Beswick DM Tags: Am J Rhinol Allergy Source Type: research

Treatment of Sinonasal Teratocarcinosarcoma: A Systematic Review and Survival Analysis.
Abstract BACKGROUND: Sinonasal teratocarcinosarcoma (SNTCS) is a rare malignancy of the anterior skull base with only 127 cases described in the English literature. Given the rarity of this tumor, new cases and analysis of published reports may assist in future management of SNTCS. OBJECTIVES: 1) Describe findings from a systematic review of all available literature for malignant SNTCS including the clinical presentation, treatment modalities and outcomes. 2) Present two new cases of this rare anterior skull base tumor. 3) Compare treatment outcomes with respect to recurrence and mortality. METHODS: A sy...
Source: American Journal of Rhinology and Allergy - September 20, 2020 Category: ENT & OMF Authors: Chapurin N, Totten DJ, Morse JC, Khurram MS, Louis PC, Sinard RJ, Chowdhury NI Tags: Am J Rhinol Allergy Source Type: research

Diagnostic Criteria of Recurrent Acute Rhinosinusitis: A Systematic Review.
CONCLUSION: The diagnostic definition for RARS has developed over time and is currently based on low level 4 and 5 evidence. Because of the migratory definition of RARS, comparing inter-study results of RARS management remains difficult, and future studies should aim to follow current expert guidelines on diagnostic criteria of RARS. PMID: 32954839 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 20, 2020 Category: ENT & OMF Authors: Saltagi MZ, Comer BT, Hughes S, Ting JY, Higgins TS Tags: Am J Rhinol Allergy Source Type: research

Treatment of Frontal Sinus Osteomyelitis in the Age of Endoscopy.
CONCLUSION: Endoscopic, endoscopic-assisted, and open approaches were utilized successfully in the current series of patients with osteomyelitis of the anterior table of the frontal sinus. While the progression of endoscopic techniques allows an additional surgical treatment option, it is important to select patients appropriately as open procedures continue to have an important role in the treatment algorithm. PMID: 32938198 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 16, 2020 Category: ENT & OMF Authors: Thompson HM, Tilak AM, Miller PL, Grayson JW, Cho DY, Woodworth BA Tags: Am J Rhinol Allergy Source Type: research

Infection After Endoscopic Dacryocystorhinostomy: Incidence and Implications.
Abstract BACKGROUND: Endoscopic dacryocystorhinostomy (EN-DCR) is an increasingly common procedure performed by otolaryngologists. While EN-DCR has a high rate of success at relieving blockage of the lacrimal system, little is known regarding associated postoperative infection (POI) rates and risk factors. OBJECTIVE: The purpose of this study was to identify factors associated with the occurrence of postoperative orbital and rhinologic infection in a large cohort of patients undergoing EN-DCR. METHODS: A retrospective review of 582 patients who underwent EN-DCR was performed. All patients received antibi...
Source: American Journal of Rhinology and Allergy - September 16, 2020 Category: ENT & OMF Authors: Jafari A, Lehmann AE, Shen SA, Banks CG, Scangas GA, Metson R Tags: Am J Rhinol Allergy Source Type: research

Assesment of Prelacrimal Recess in Patients With Maxillary Sinus Hypoplasia Using Cone Beam Computed Tomography.
CONCLUSIONS: The width of the antero-posterior PLR in patients with Maxillary Sinus Hypoplasia was found to be significantly lower in comparison to individuals with normal maxillary sinuses in the measurements performed on paranasal Cone Beam Computed Tomography scans. Hence, while planning a Functional Endoscopic Sinus Surgery with prelacrimal recess approach for maxillary sinus, the anatomical structure of the naso-sinusoidal region should be carefully analyzed, and individual anatomical variations such as Maxillary Sinus Hypoplasia should not be ignored. PMID: 32927966 [PubMed - as supplied by publisher] (Source: A...
Source: American Journal of Rhinology and Allergy - September 14, 2020 Category: ENT & OMF Authors: Duman SB, Gumussoy İ Tags: Am J Rhinol Allergy Source Type: research

Risk Factors for Rhinosinusitis After Endoscopic Transsphenoidal Adenomectomy.
CONCLUSION: This is the first study to investigate preoperative sinonasal disease as a risk factor for PRS after eTSA. The risk factors considered did not demonstrate definitive risk for PRS, although a history of prior sinonasal surgery should be investigated further. PMID: 32921135 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 13, 2020 Category: ENT & OMF Authors: Lee CH, Ikeda AK, Patel S, Levy JM, Patel ZM, Arturo Solares C, Oyesiku N, Wise SK Tags: Am J Rhinol Allergy Source Type: research

The Effect of Nasoseptal Flap Elevation on Post-Operative Olfaction and Sinonasal Quality of Life: A Prospective Double-Blinded Randomized Controlled Trial.
CONCLUSIONS: The use of NSF during EEA for sellar pathology does not have a significant effect on olfaction or rhinologic QOL. The presence of a dominant side of olfaction is not a primary consideration when deciding the side of NSF harvest. PMID: 32921136 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 13, 2020 Category: ENT & OMF Authors: Chou CT, Valappil B, Mattos JL, Snyderman CH, Gardner PA, Fernandez-Miranda JC, Wang EW Tags: Am J Rhinol Allergy Source Type: research

A Systematic Review of the Neuropathologic Findings of Post-Viral Olfactory Dysfunction: Implications and Novel Insight for the COVID-19 Pandemic.
CONCLUSIONS: The mechanism of post-viral olfactory dysfunction is highly complex, virus-dependent, and involves a combination of insults at multiple levels of the olfactory pathway. This will have important implications for future diagnostic and therapeutic developments for patients infected with COVID-19. PMID: 32915650 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 11, 2020 Category: ENT & OMF Authors: Lee JC, Nallani R, Cass L, Bhalla V, Chiu AG, Villwock JA Tags: Am J Rhinol Allergy Source Type: research

Academic Rhinologists' Online Rating and Perception, Scholarly Productivity, and Industry Payments.
Abstract INTRODUCTION: The emergence of popular online rating websites, social media platforms, and public databases for industry payments and scholarly outputs provide a complete physician online presence which may guide choice and satisfaction. METHODS: Websites of all U.S. otolaryngology academic institutions were queried for fellowship-trained rhinologists. Additional well-known and academically active rhinologists were identified by the senior author. Online ratings and comments were collected from Google, Healthgrades, Vitals, and RateMD websites, and weighted rating scores (RS) were calculated on a 1-5...
Source: American Journal of Rhinology and Allergy - September 11, 2020 Category: ENT & OMF Authors: Goshtasbi K, Lehrich BM, Abouzari M, Bazyani D, Abiri A, Papagiannopoulos P, Tajudeen BA, Kuan EC Tags: Am J Rhinol Allergy Source Type: research

Evaluating the Relationship Between Olfactory Function and Loneliness in Community-Dwelling Individuals: A Cross-sectional Study.
Abstract BACKGROUND: Olfactory dysfunction (OD) has been reported to impact social interactions. However, the relationship between OD and loneliness has received little attention. The purpose of this study was to determine the association between OD and loneliness, controlling for patient factors. METHODS: Subjects without otolaryngic complaints were enrolled and olfactory function was assessed using: Sniffin' Sticks test to measure threshold, discrimination and identification (TDI), Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and 9 - item Olfactory-Visual Analogue Scale (VAS). Lonelines...
Source: American Journal of Rhinology and Allergy - September 11, 2020 Category: ENT & OMF Authors: Desiato VM, Soler ZM, Nguyen SA, Salvador C, Hill JB, Lamira J, Rowan NR, Yoo F, Little RE, Matthews LJ, Dubno JR, Schlosser RJ Tags: Am J Rhinol Allergy Source Type: research

Redefining Pregnancy-Induced Rhinitis.
CONCLUSIONS: PIR is a common clinical entity with a wide range of symptoms with a direct impact on the quality of life in pregnancy. We propose a new definition of pregnancy-induced rhinitis. PMID: 32903019 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - September 9, 2020 Category: ENT & OMF Authors: Baudoin T, Šimunjak T, Bacan N, Jelavić B, Kuna K, Košec A Tags: Am J Rhinol Allergy Source Type: research

Symptoms and Clinical Findings in Primary Headache Syndrome Versus Chronic Rhinosinusitis.
In this study, we compare demographic, subjective, and objective clinical findings of patients with PHS versus CRS. METHODS: We retrospectively reviewed a database of patients presenting to a single tertiary care Rhinology clinic from December 2011-July 2017. Sino-Nasal Outcome Test-22 (SNOT) scores and Lund-Kennedy endoscopy scores were obtained. Lund-MacKay CT scores were calculated, if available. Requirement of headache specialist management was compared between PHS and CRS groups. Patients with both CRS and PHS (CRScPHS) that required headache specialist management were compared to patients with CRS without PHS (C...
Source: American Journal of Rhinology and Allergy - September 3, 2020 Category: ENT & OMF Authors: Sharbel DD, Owen HC, Yelverton JC, Li M, Holmes T, Kountakis SE Tags: Am J Rhinol Allergy Source Type: research

Editorial.
PMID: 32772740 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 13, 2020 Category: ENT & OMF Authors: McKinney KA Tags: Am J Rhinol Allergy Source Type: research

Factors Important in the Selection of a Rhinology/Skull Base Surgery Fellow: A National Survey of Fellowship Directors.
CONCLUSION: Numerous academic achievements and personal characteristics are given consideration in the Rhinology/Skull Base Surgery fellowship selection process, but recommendation from a trusted colleague and performance on interviews were viewed to be the most critical factors for fellowship programs in selecting applicants. This is consistent with studies that have explored the selection process for other otolaryngology fellowship programs. PMID: 32777928 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 10, 2020 Category: ENT & OMF Authors: Johnson J, Stathakios J, Chung MT, Engel R, Folbe A Tags: Am J Rhinol Allergy Source Type: research

Viral Infections of the Upper Airway in the Setting of COVID-19: A Primer for Rhinologists.
CONCLUSION: In light of these unprecedented times, the need to understand the nuances of these viral respiratory pathogens, especially SARS-CoV-2, cannot be overemphasized. This knowledge base is of particular importance to otolaryngologists, whose expertise in the upper airway coincides with the anatomic tropism of these infectious agents. PMID: 32762250 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 6, 2020 Category: ENT & OMF Authors: Yuen E, Gudis DA, Rowan NR, Nguyen SA, Schlosser RJ Tags: Am J Rhinol Allergy Source Type: research

Endoscopic Study of the Distribution of Olfactory Filaments: A Cadaveric Study.
Abstract OBJECTIVE: Provide a detailed anatomical description of the olfactory filaments (OF) and their distribution in the nasal cavity through endoscopic endonasal dissection. METHODS: Four cadaveric specimens (8 sides) were used in this study. Nasoseptal (NSM), middle (MTM) and superior turbinate (STM) mucosa dissection was performed to identify the OF and follow them superiorly to the cribriform plate (CP). Measurements of the OF were taken on the NSM, MTM, STM under direct endoscopic visualization. A Student's T-Test was performed to compare means. RESULTS: The NSM contained a mean of 11 OF, distrib...
Source: American Journal of Rhinology and Allergy - August 6, 2020 Category: ENT & OMF Authors: Soriano RM, Arturo Solares C, Pradilla G, DelGaudio JM Tags: Am J Rhinol Allergy Source Type: research

Outcomes in Treatment of Rhinosinusitis in the Setting of Medication Induced Immunosuppression.
CONCLUSION: Patients experiencing chronic rhinosinusitis and recurrent acute rhinosinusitis who are taking immunosuppressive medication can significantly improve from both medical and surgical management, but upfront surgical management appears to result in greater disease resolution relative to medical management in those with CRS. More study is needed in the RARS patient population regarding upfront surgery versus medical management. PMID: 32746611 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 3, 2020 Category: ENT & OMF Authors: Alapati R, Nayak JV, Hwang PH, Patel ZM Tags: Am J Rhinol Allergy Source Type: research

The Prevalence of Olfactory Dysfunction in the General Population: A Systematic Review and Meta-analysis.
Abstract BACKGROUND: Olfactory dysfunction (OD) is common and has been reported as an early indicator of COVID-19. However, the reported prevalence of OD in the general population varies widely depending upon the metric used to assess olfaction.Methodology/Principal: To perform a systematic review and meta-analysis of the prevalence of OD in the healthy general population, review the various assessment metrics used, and compare pooled OD prevalence rates. RESULTS: A total of 175,073 subjects were identified (mean age 63.5 years, range 18 to 101) with an overall OD prevalence of 22.2% (95% CI 14.8-30.6)...
Source: American Journal of Rhinology and Allergy - August 3, 2020 Category: ENT & OMF Authors: Desiato VM, Levy DA, Byun YJ, Nguyen SA, Soler ZM, Schlosser RJ Tags: Am J Rhinol Allergy Source Type: research

Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells.
CONCLUSIONS: GO and MGO induced pro-inflammatory cytokines and MUC5AC/5B expression via ERK1/2, p38 MAPK, and NF-κB in human nasal epithelial cells. These results suggested that GO and MGO may be involved in mucus hypersecretion-related airway diseases. PMID: 32746708 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 3, 2020 Category: ENT & OMF Authors: Kwak S, Choi YS, Na HG, Bae CH, Song SY, Kim YD Tags: Am J Rhinol Allergy Source Type: research

Treatment Strategy for Odontogenic Sinusitis.
CONCLUSIONS: Two-thirds of the patients with OS caused by dental caries and periapical abscess were cured with dental treatment and medical management without ESS. We recommend dental treatment and medical management first in OS caused by dental caries and periapical abscess. However, we recommend early ESS in patients with smoking habits and severe CT findings of the sinus. PMID: 32722916 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 28, 2020 Category: ENT & OMF Authors: Yoo BJ, Jung SM, Lee HN, Kim HG, Chung JH, Jeong JH Tags: Am J Rhinol Allergy Source Type: research

Impact of Post-Surgical Therapies on Endoscopic and External Dacryocystorhinostomy: Systematic Review and Meta-Analysis.
CONCLUSIONS: Given the high success rate of EXT-DCR and END-DCR and the heterogeneity of literature data, the effective influence of post-surgical medical therapy is difficult to identify. Future large prospective randomized studies could help in detecting the optimal adjunctive therapy for these surgeries. PMID: 32703027 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 23, 2020 Category: ENT & OMF Authors: Vinciguerra A, Nonis A, Resti AG, Bussi M, Trimarchi M Tags: Am J Rhinol Allergy Source Type: research

Eosinophilic Mucin: A Predictor for Disease Severity in Chronic Rhinosinusitis.
Abstract OBJECTIVE: The presence of tissue eosinophilia is a determinate of disease severity in patients with chronic rhinosinusitis (CRS). The impact of eosinophilic mucin (EM) as an independent variable has not yet been elucidated. STUDY DESIGN: Retrospective review. SETTING: Tertiary academic clinic.Subjects Methods: CRS patients who failed medical therapy were classified by tissue eosinophilia, presence of polyps and EM. Tissue eosinophilia count per high power field (HPF) as well as the presence of EM were determined by pathologic examination of sinus tissue removed during surgery. Sinonasal Outcome...
Source: American Journal of Rhinology and Allergy - July 20, 2020 Category: ENT & OMF Authors: Unsal AA, Reyes C, Biddinger P, Kountakis SE Tags: Am J Rhinol Allergy Source Type: research

Differentiation of Clinical Patterns Associated With Rhinologic Disease.
CONCLUSION: Broader consideration of initially available clinical data may improve diagnostic efficiency for rhinologic conditions without ancillary studies, using computer-driven algorithms. PRQOL scores and demographic information appeared to be useful adjuncts, with associations to diagnoses in this pilot study. PMID: 32664744 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 14, 2020 Category: ENT & OMF Authors: Parsel SM, Riley CA, Todd CA, Thomas AJ, McCoul ED Tags: Am J Rhinol Allergy Source Type: research

A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease.
Abstract BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized. OBJECTIVE: The aim of this radiographic study is to characterize the bony changes noted on computed tomography (CT) scans of the sphenoid sinus in patients with AERD compared to other diseased sinonasal inflammatory states and non-diseased controls. METHODS: A retrospective review of 43 patients with clinically confirmed AERD were included and compared to 22 non-diseased, 9 aller...
Source: American Journal of Rhinology and Allergy - July 13, 2020 Category: ENT & OMF Authors: Malfitano MJ, Santarelli GD, Gelpi M, Brown WC, Stepp WH, Hernandez S, Kimple AJ, Thorp BD, Zanation AM, Ebert CS Tags: Am J Rhinol Allergy Source Type: research

Prognostic Factors of Sinonasal Squamous Cell Carcinomas Arising De Novo and From Inverted Papilloma.
CONCLUSION: IP-associated SCCs have an aggressive loco-regional tendency, whereas de novo SCCs have a higher aggressive distant metastatic propensity. Age, tumor stage and surgical positive margin are key factors for poor prognosis and should be routinely taken into consideration during treatment planning and subsequent surveillance. PMID: 32659112 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 12, 2020 Category: ENT & OMF Authors: Li Y, Wang C, Wang R, Zhang J, Liu H, Shi Q, Chen X, Hou L, Ma H, Zhong Q, Li P, Feng L, He S, Zhang L, Fang J Tags: Am J Rhinol Allergy Source Type: research

Predicting Odontogenic Sinusitis in Unilateral Sinus Disease: A Prospective, Multivariate Analysis.
CONCLUSION: With unilateral maxillary sinus disease, the following features were significantly associated with ODS: foul smell, ipsilateral facial pressure, middle meatal pus on endoscopy, and any frontal sinus opacification on sinus CT. Additionally, any sphenoid sinus opacification on CT was inversely related to ODS. Presence or absence of these clinical variables can be used to increase or decrease one's suspicion of an odontogenic source of sinusitis. PMID: 32646233 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 9, 2020 Category: ENT & OMF Authors: Goyal VK, Ahmad A, Turfe Z, Peterson EI, Craig JR Tags: Am J Rhinol Allergy Source Type: research

Radiologic Analysis of Balloon Sinuplasty in a Human Cadaver Model: Observed Effects on Sinonasal Anatomy.
CONCLUSIONS: While the goal of balloon sinuplasty is to improve natural sinonasal drainage by dilating existing outflow tracts, as evidenced by radiologic evaluation the procedure appears not to achieve this in all cases, while occasionally creating unintended changes in sinonasal anatomy as well. These unrecognized changes in anatomy may be responsible for the post-procedure change in symptomatology that some patients experience. PMID: 32635741 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 7, 2020 Category: ENT & OMF Authors: Lopez EM, Farzal Z, Norris M, Canfarotta MW, Pappa AK, Santarelli GD, Hernandez SC, Thorp BD, Senior BA, Zanation AM, Ebert CS, Kimbell JS, Kimple AJ Tags: Am J Rhinol Allergy Source Type: research

miR-30a-5p Inhibits Epithelial-to-Mesenchymal Transition by Targeting CDK6 in Nasal Polyps.
CONCLUSION: Taken together, our results suggested that EMT was involved in NPs, and overexpression of miR-30a-5p could attenuate EMT via repressing the expression of the CDK6 in pHNECs and A549 cells. PMID: 32623901 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 5, 2020 Category: ENT & OMF Authors: Zhang T, Zhou Y, You B, You Y, Yan Y, Zhang J, Pei Y, Zhang W, Chen J Tags: Am J Rhinol Allergy Source Type: research

How Can We Reduce the Use of Nasal Endoscopy in the Outpatient Setting During COVID-19?
PMID: 32615770 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 3, 2020 Category: ENT & OMF Authors: Pendolino AL, Randhawa PS, Andrews PJ Tags: Am J Rhinol Allergy Source Type: research

Nasal Endoscopy During COVID-19.
PMID: 32615774 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 3, 2020 Category: ENT & OMF Authors: Taha MA, Hall CA, Barham HP Tags: Am J Rhinol Allergy Source Type: research

Staying Safe, Caring for Each Other, and Moving the Needle-Together.
PMID: 32479163 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - June 3, 2020 Category: ENT & OMF Authors: Sindwani R Tags: Am J Rhinol Allergy Source Type: research

Chronic Odontogenic Rhinosinusitis: Optimization of Surgical Treatment Indications.
kus S Abstract BACKGROUND: The treatment of chronic odontogenic and nonodontogenic rhinosinusitis is different. It requires the elimination of odontogenic cause and optimal sinus surgical treatment. To date, there are no clear indications when sinus surgical treatment is necessary. OBJECTIVE: Our aim was to define clear indication(s) for sinus surgical treatment in patients with chronic odontogenic rhinosinusitis after elimination of odontogenic cause. METHODS: A group of 96 patients with chronic odontogenic rhinosinusitis caused by apical periodontitis completed a Sino-Nasal Outcome Test 22 (SNOT-22) qu...
Source: American Journal of Rhinology and Allergy - May 31, 2020 Category: ENT & OMF Authors: Simuntis R, Kubilius R, Tušas P, Leketas M, Vaitkus J, Vaitkus S Tags: Am J Rhinol Allergy Source Type: research

Readability of Printed Online Education Materials on Pituitary Tumors: Untangling a Web of Complexity.
Abstract BACKGROUND: Patients are increasingly turning to the internet for health education. Due to the complex pathophysiology, clinic-diagnostic profile, and management spectrum of pituitary tumors, an evaluation of the readability of printed online education materials (POEMs) regarding this entity is warranted. OBJECTIVE: (1) To apply established readability assessment tools to internet search results on the topic of pituitary tumors. (2) To identify sources of complexity in order to guide the creation POEMs that are in line with the reading level of the target audience. Methodology: After independent, neu...
Source: American Journal of Rhinology and Allergy - May 27, 2020 Category: ENT & OMF Authors: Ye MJ, Alwani MM, Harper JL, Buren LMV, Bandali EH, Illing EA, Shipchandler TZ, Ting JY Tags: Am J Rhinol Allergy Source Type: research

Chronic Rhinosinusitis Patients With and Without Polyps Experience Different Symptom Perception and Quality of Life Burdens.
Abstract OBJECTIVE: We sought to determine if chronic rhinosinusitis (CRS) patients with nasal polyps (CRSwNP) differentially perceived CRS symptom burden compared to patients without nasal polyps (CRSsNP) and to what extent CRS symptom severity was associated with quality of life (QOL) and patient-reported symptom control in the 2 groups. METHODS: A total of 600 patients (266 CRSwNP and 334 CRSsNP) presenting with CRS were recruited. CRS symptom burden was assessed with the 22-item Sinonasal Outcome Test (SNOT-22). SNOT-22 nasal, sleep, ear/facial discomfort, and emotional subdomain scores were calculated. G...
Source: American Journal of Rhinology and Allergy - May 21, 2020 Category: ENT & OMF Authors: Talat R, Speth MM, Gengler I, Phillips KM, Caradonna DS, Gray ST, Sedaghat AR Tags: Am J Rhinol Allergy Source Type: research

Effectiveness Comparison of Dexmedetomidine and Remifentanil for Perioperative Management in Patients Undergoing Endoscopic Sinus Surgery.
In this study, the patients were randomly divided into the dexmedetomidine and remifentanil groups. During the intraoperative period, the hemodynamic values were recorded. The surgical condition was assessed by a single surgeon. During the postoperative period, hemodynamic values, sedation scale score, and pain score were recorded. RESULT: No significant differences in hemodynamic variables were found between the groups before and after intranasal injection of epinephrine. Comparison of the group mean values before endotracheal intubation revealed that the blood pressure values in the remifentanil group were significa...
Source: American Journal of Rhinology and Allergy - May 21, 2020 Category: ENT & OMF Authors: Huh H, Park JJ, Seong HY, Lee SH, Yoon SZ, Cho JE Tags: Am J Rhinol Allergy Source Type: research

Rhinologic Procedures in the Era of COVID-19: Health-care Provider Protection Protocol.
CONCLUSION: According to our proposed protocol, we were able to provide care for all patients in clinic, hospital, emergent, intensive, and surgical settings with no transmission of SARS-CoV-2 by symptomatology and post evaluation testing. PMID: 32408753 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 14, 2020 Category: ENT & OMF Authors: Taha MA, Hall CA, Rathbone RF, Corsten LA, Bowie CR, Waguespack PJ, Stanger R, Stevenson MM, Zito BA, Barham HP Tags: Am J Rhinol Allergy Source Type: research

Severity of Rhinosinusitis: Comparison Between Visual Analog Scale Given by Patients and Otorhinolaryngologists.
CONCLUSIONS: VAS scores between patients and physicians are not correlated significantly in this study, but they fall within the same therapeutic range and do not change the clinical management of the patients. PMID: 32403940 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 13, 2020 Category: ENT & OMF Authors: Zhao L, Yu KN, Tan JL, Zhang HL, Jin P, Zi XX, Tu YY, Li T, Zhou XM, Shi L, Wang Y Tags: Am J Rhinol Allergy Source Type: research

Evaluation of Performance and Tolerability of Nebulized Hyaluronic Acid Nasal Hypertonic Solution in the Treatment of Chronic Rhinosinusitis.
CONCLUSIONS: The use of the investigated new nebulized HA nasal hypertonic solution is an effective and safe the treatment of CRS. PMID: 32403941 [PubMed - as supplied by publisher] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 13, 2020 Category: ENT & OMF Authors: Monzani D, Molinari G, Gherpelli C, Michellini L, Alicandri-Ciufelli M Tags: Am J Rhinol Allergy Source Type: research

Computed Tomography Findings Can Help Identify Different Chronic Rhinosinusitis With Nasal Polyp Phenotypes.
Abstract BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNPs) has several phenotypes. OBJECTIVES: The goal of this study was to evaluate computed tomography (CT) findings associated with each CRSwNP phenotype. METHODS: Patient charts between January 2015 and March 2019 were retrospectively reviewed. Patient groups, including allergic fungal rhinosinusitis (AFRS), aspirin-exacerbated respiratory disease (AERD), central compartment atopic disease (CCAD) and CRSwNP not otherwise specified (CRSwNP NOS), were determined by standard criteria. The oldest CT scan available was reviewed for Lund-Mackay ...
Source: American Journal of Rhinology and Allergy - May 6, 2020 Category: ENT & OMF Authors: Roland LT, Marcus S, Schertzer JS, Wise SK, Levy JM, DelGaudio JM Tags: Am J Rhinol Allergy Source Type: research

Consortium of Otolaryngology Journal Editors: Collegiality and Contributions.
PMID: 32268791 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 11, 2020 Category: ENT & OMF Authors: Sataloff RT, Chandra R, Fisher EW, Goldenberg D, Hanna EY, Johnson J, Kennedy DW, Kraus DH, Krouse JH, Link M, Lustig LR, O'Malley BW, Piccirillo JF, Ruben R, Schwartz S, Selesnick SH, Sindwani R, Smith RJ, Stewart MG, Tysome J, Weber PC, Welling DB Tags: Am J Rhinol Allergy Source Type: research

2019 Reviewer Thank You.
Authors: PMID: 32268792 [PubMed - in process] (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 11, 2020 Category: ENT & OMF Tags: Am J Rhinol Allergy Source Type: research