Investigation of Repeatability of Peak Nasal Inspiratory Flow Rate Measurements Under Baseline Conditions and After Administration of 0.05% Oxymetazoline
CONCLUSIONS: 1. No statistically significant difference was observed in PNIF values only between the fourth and fifth measurements; therefore, at least three measurements are essential to draw meaningful conclusions. 2. PNIF measurements were satisfactorily characterized by a relatively low CV (15%). 3. The administration of 0.05% oxymetazoline led to an increase in PNIF by approximately 14% over the baseline value.PMID:33957801 | DOI:10.1177/19458924211015584 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 7, 2021 Category: ENT & OMF Authors: Anna Dor-Wojnarowska Anna Radli ńska Marek Rabski Andrzej Fal Jerzy Liebhart Anna Zaleska Mariana Babchyshyn Boles ław Samoliński Source Type: research

Investigation of Repeatability of Peak Nasal Inspiratory Flow Rate Measurements Under Baseline Conditions and After Administration of 0.05% Oxymetazoline
CONCLUSIONS: 1. No statistically significant difference was observed in PNIF values only between the fourth and fifth measurements; therefore, at least three measurements are essential to draw meaningful conclusions. 2. PNIF measurements were satisfactorily characterized by a relatively low CV (15%). 3. The administration of 0.05% oxymetazoline led to an increase in PNIF by approximately 14% over the baseline value.PMID:33957801 | DOI:10.1177/19458924211015584 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - May 7, 2021 Category: ENT & OMF Authors: Anna Dor-Wojnarowska Anna Radli ńska Marek Rabski Andrzej Fal Jerzy Liebhart Anna Zaleska Mariana Babchyshyn Boles ław Samoliński Source Type: research

Identification of Heat Shock Protein 90 as a Recurrence Related Marker in Juvenile Nasopharyngeal Angiofibroma
Am J Rhinol Allergy. 2021 May 3:19458924211012820. doi: 10.1177/19458924211012820. Online ahead of print.ABSTRACTBACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) is a highly recurrent tumor after curative surgery.OBJECTIVE: The purpose of this study was to evaluate heat shock protein 90 (HSP90) expression in JNA and its association with tumor recurrence.METHODS: Immunohistochemistry was performed to assess HSP90 expression using tissue microarrays containing 70 JNA patients and 10 control subjects. The associations of HSP90 expression with clinicopathological features and tumor recurrence were analyzed.RESULTS: Immun...
Source: American Journal of Rhinology and Allergy - May 4, 2021 Category: ENT & OMF Authors: Jingjing Wang Li Hu Zhuofu Liu Huan Wang Huankang Zhang Xiaole Song XiCai Sun DeHui Wang Source Type: research

Identification of Heat Shock Protein 90 as a Recurrence Related Marker in Juvenile Nasopharyngeal Angiofibroma
Am J Rhinol Allergy. 2021 May 3:19458924211012820. doi: 10.1177/19458924211012820. Online ahead of print.ABSTRACTBACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) is a highly recurrent tumor after curative surgery.OBJECTIVE: The purpose of this study was to evaluate heat shock protein 90 (HSP90) expression in JNA and its association with tumor recurrence.METHODS: Immunohistochemistry was performed to assess HSP90 expression using tissue microarrays containing 70 JNA patients and 10 control subjects. The associations of HSP90 expression with clinicopathological features and tumor recurrence were analyzed.RESULTS: Immun...
Source: American Journal of Rhinology and Allergy - May 4, 2021 Category: ENT & OMF Authors: Jingjing Wang Li Hu Zhuofu Liu Huan Wang Huankang Zhang Xiaole Song XiCai Sun DeHui Wang Source Type: research

Identification of Heat Shock Protein 90 as a Recurrence Related Marker in Juvenile Nasopharyngeal Angiofibroma
Am J Rhinol Allergy. 2021 May 3:19458924211012820. doi: 10.1177/19458924211012820. Online ahead of print.ABSTRACTBACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) is a highly recurrent tumor after curative surgery.OBJECTIVE: The purpose of this study was to evaluate heat shock protein 90 (HSP90) expression in JNA and its association with tumor recurrence.METHODS: Immunohistochemistry was performed to assess HSP90 expression using tissue microarrays containing 70 JNA patients and 10 control subjects. The associations of HSP90 expression with clinicopathological features and tumor recurrence were analyzed.RESULTS: Immun...
Source: American Journal of Rhinology and Allergy - May 4, 2021 Category: ENT & OMF Authors: Jingjing Wang Li Hu Zhuofu Liu Huan Wang Huankang Zhang Xiaole Song XiCai Sun DeHui Wang Source Type: research

Assessment of Biomarker Heterogeneity in Sinus Versus Inferior Turbinate Tissue in Patients Without Chronic Rhinosinusitis
Am J Rhinol Allergy. 2021 Apr 28:19458924211012808. doi: 10.1177/19458924211012808. Online ahead of print.ABSTRACTBACKGROUND: Currently, no consensus exists on the appropriate control specimen site to utilize in studies evaluating for biomarkers in chronic rhinosinusitis (CRS). Studies thus far have utilized tissue from various anatomic sites despite regional heterogeneity.OBJECTIVE: We set out to quantify the differences in biomarker levels present in inferior turbinate versus sphenoid sinus mucosa in paired healthy control patients. We hypothesize that statistically significant differences in cytokine/chemokine expressio...
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Taylor R Carle Tara J Wu Vivian Wung Jeffrey D Suh Marilene B Wang Christine R Wells Maura Rossetti Jivianne T Lee Source Type: research

Olfaction and Beyond: Advancing Our Understanding for Evidence-Based Practice
Am J Rhinol Allergy. 2021 May;35(3):284-287. doi: 10.1177/19458924211012799.NO ABSTRACTPMID:33910386 | DOI:10.1177/19458924211012799 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Anna Knisely Source Type: research

Assessment of Biomarker Heterogeneity in Sinus Versus Inferior Turbinate Tissue in Patients Without Chronic Rhinosinusitis
Am J Rhinol Allergy. 2021 Apr 28:19458924211012808. doi: 10.1177/19458924211012808. Online ahead of print.ABSTRACTBACKGROUND: Currently, no consensus exists on the appropriate control specimen site to utilize in studies evaluating for biomarkers in chronic rhinosinusitis (CRS). Studies thus far have utilized tissue from various anatomic sites despite regional heterogeneity.OBJECTIVE: We set out to quantify the differences in biomarker levels present in inferior turbinate versus sphenoid sinus mucosa in paired healthy control patients. We hypothesize that statistically significant differences in cytokine/chemokine expressio...
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Taylor R Carle Tara J Wu Vivian Wung Jeffrey D Suh Marilene B Wang Christine R Wells Maura Rossetti Jivianne T Lee Source Type: research

Olfaction and Beyond: Advancing Our Understanding for Evidence-Based Practice
Am J Rhinol Allergy. 2021 May;35(3):284-287. doi: 10.1177/19458924211012799.NO ABSTRACTPMID:33910386 | DOI:10.1177/19458924211012799 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Anna Knisely Source Type: research

Assessment of Biomarker Heterogeneity in Sinus Versus Inferior Turbinate Tissue in Patients Without Chronic Rhinosinusitis
Am J Rhinol Allergy. 2021 Apr 28:19458924211012808. doi: 10.1177/19458924211012808. Online ahead of print.ABSTRACTBACKGROUND: Currently, no consensus exists on the appropriate control specimen site to utilize in studies evaluating for biomarkers in chronic rhinosinusitis (CRS). Studies thus far have utilized tissue from various anatomic sites despite regional heterogeneity.OBJECTIVE: We set out to quantify the differences in biomarker levels present in inferior turbinate versus sphenoid sinus mucosa in paired healthy control patients. We hypothesize that statistically significant differences in cytokine/chemokine expressio...
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Taylor R Carle Tara J Wu Vivian Wung Jeffrey D Suh Marilene B Wang Christine R Wells Maura Rossetti Jivianne T Lee Source Type: research

Olfaction and Beyond: Advancing Our Understanding for Evidence-Based Practice
Am J Rhinol Allergy. 2021 May;35(3):284-287. doi: 10.1177/19458924211012799.NO ABSTRACTPMID:33910386 | DOI:10.1177/19458924211012799 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Anna Knisely Source Type: research

Assessment of Biomarker Heterogeneity in Sinus Versus Inferior Turbinate Tissue in Patients Without Chronic Rhinosinusitis
Am J Rhinol Allergy. 2021 Apr 28:19458924211012808. doi: 10.1177/19458924211012808. Online ahead of print.ABSTRACTBACKGROUND: Currently, no consensus exists on the appropriate control specimen site to utilize in studies evaluating for biomarkers in chronic rhinosinusitis (CRS). Studies thus far have utilized tissue from various anatomic sites despite regional heterogeneity.OBJECTIVE: We set out to quantify the differences in biomarker levels present in inferior turbinate versus sphenoid sinus mucosa in paired healthy control patients. We hypothesize that statistically significant differences in cytokine/chemokine expressio...
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Taylor R Carle Tara J Wu Vivian Wung Jeffrey D Suh Marilene B Wang Christine R Wells Maura Rossetti Jivianne T Lee Source Type: research

Olfaction and Beyond: Advancing Our Understanding for Evidence-Based Practice
Am J Rhinol Allergy. 2021 May;35(3):284-287. doi: 10.1177/19458924211012799.NO ABSTRACTPMID:33910386 | DOI:10.1177/19458924211012799 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Anna Knisely Source Type: research

Assessment of Biomarker Heterogeneity in Sinus Versus Inferior Turbinate Tissue in Patients Without Chronic Rhinosinusitis
Am J Rhinol Allergy. 2021 Apr 28:19458924211012808. doi: 10.1177/19458924211012808. Online ahead of print.ABSTRACTBACKGROUND: Currently, no consensus exists on the appropriate control specimen site to utilize in studies evaluating for biomarkers in chronic rhinosinusitis (CRS). Studies thus far have utilized tissue from various anatomic sites despite regional heterogeneity.OBJECTIVE: We set out to quantify the differences in biomarker levels present in inferior turbinate versus sphenoid sinus mucosa in paired healthy control patients. We hypothesize that statistically significant differences in cytokine/chemokine expressio...
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Taylor R Carle Tara J Wu Vivian Wung Jeffrey D Suh Marilene B Wang Christine R Wells Maura Rossetti Jivianne T Lee Source Type: research

Olfaction and Beyond: Advancing Our Understanding for Evidence-Based Practice
Am J Rhinol Allergy. 2021 May;35(3):284-287. doi: 10.1177/19458924211012799.NO ABSTRACTPMID:33910386 | DOI:10.1177/19458924211012799 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 29, 2021 Category: ENT & OMF Authors: Anna Knisely Source Type: research

Comorbidities Known to Affect Physical Function Negatively Impact Baseline Health-Related Quality-of-Life in Patients With Chronic Rhinosinusitis
CONCLUSIONS: Major medical comorbidities known to affect physical function are associated with worse SNOT-22 scores in patients with CRS as measured by the FCI.PMID:33906469 | DOI:10.1177/19458924211013610 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 28, 2021 Category: ENT & OMF Authors: Amarbir S Gill Shaelene Ashby Gretchen M Oakley Toby O Steele Dennis Menjivar Richard R Orlandi Jeremiah A Alt Source Type: research

Comorbidities Known to Affect Physical Function Negatively Impact Baseline Health-Related Quality-of-Life in Patients With Chronic Rhinosinusitis
CONCLUSIONS: Major medical comorbidities known to affect physical function are associated with worse SNOT-22 scores in patients with CRS as measured by the FCI.PMID:33906469 | DOI:10.1177/19458924211013610 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 28, 2021 Category: ENT & OMF Authors: Amarbir S Gill Shaelene Ashby Gretchen M Oakley Toby O Steele Dennis Menjivar Richard R Orlandi Jeremiah A Alt Source Type: research

Long Term Outcomes of Nasoseptal Perforation Repair With an Anterior Ethmoidal Artery Flap
CONCLUSION: The anterior ethmoidal artery flap is a reliable and minimal invasive technique for closure of symptomatic perforations. For defects larger than 2 cm, a lower success rate and additional reconstructive measures should be considered. Objective questionnaires are needed in order to evaluate functional outcomes.PMID:33878936 | DOI:10.1177/19458924211012120 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 21, 2021 Category: ENT & OMF Authors: Jacopo Zocchi Federico Russo Luca Volpi Hassan Ahmed Elhassan Giacomo Pietrobon Alberto Arosio Maurizio Bignami Paolo Castelnuovo Source Type: research

Long Term Outcomes of Nasoseptal Perforation Repair With an Anterior Ethmoidal Artery Flap
CONCLUSION: The anterior ethmoidal artery flap is a reliable and minimal invasive technique for closure of symptomatic perforations. For defects larger than 2 cm, a lower success rate and additional reconstructive measures should be considered. Objective questionnaires are needed in order to evaluate functional outcomes.PMID:33878936 | DOI:10.1177/19458924211012120 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 21, 2021 Category: ENT & OMF Authors: Jacopo Zocchi Federico Russo Luca Volpi Hassan Ahmed Elhassan Giacomo Pietrobon Alberto Arosio Maurizio Bignami Paolo Castelnuovo Source Type: research

Long Term Outcomes of Nasoseptal Perforation Repair With an Anterior Ethmoidal Artery Flap
CONCLUSION: The anterior ethmoidal artery flap is a reliable and minimal invasive technique for closure of symptomatic perforations. For defects larger than 2 cm, a lower success rate and additional reconstructive measures should be considered. Objective questionnaires are needed in order to evaluate functional outcomes.PMID:33878936 | DOI:10.1177/19458924211012120 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 21, 2021 Category: ENT & OMF Authors: Jacopo Zocchi Federico Russo Luca Volpi Hassan Ahmed Elhassan Giacomo Pietrobon Alberto Arosio Maurizio Bignami Paolo Castelnuovo Source Type: research

Long Term Outcomes of Nasoseptal Perforation Repair With an Anterior Ethmoidal Artery Flap
CONCLUSION: The anterior ethmoidal artery flap is a reliable and minimal invasive technique for closure of symptomatic perforations. For defects larger than 2 cm, a lower success rate and additional reconstructive measures should be considered. Objective questionnaires are needed in order to evaluate functional outcomes.PMID:33878936 | DOI:10.1177/19458924211012120 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 21, 2021 Category: ENT & OMF Authors: Jacopo Zocchi Federico Russo Luca Volpi Hassan Ahmed Elhassan Giacomo Pietrobon Alberto Arosio Maurizio Bignami Paolo Castelnuovo Source Type: research

Long Term Outcomes of Nasoseptal Perforation Repair With an Anterior Ethmoidal Artery Flap
CONCLUSION: The anterior ethmoidal artery flap is a reliable and minimal invasive technique for closure of symptomatic perforations. For defects larger than 2 cm, a lower success rate and additional reconstructive measures should be considered. Objective questionnaires are needed in order to evaluate functional outcomes.PMID:33878936 | DOI:10.1177/19458924211012120 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 21, 2021 Category: ENT & OMF Authors: Jacopo Zocchi Federico Russo Luca Volpi Hassan Ahmed Elhassan Giacomo Pietrobon Alberto Arosio Maurizio Bignami Paolo Castelnuovo Source Type: research

Long Term Outcomes of Nasoseptal Perforation Repair With an Anterior Ethmoidal Artery Flap
CONCLUSION: The anterior ethmoidal artery flap is a reliable and minimal invasive technique for closure of symptomatic perforations. For defects larger than 2 cm, a lower success rate and additional reconstructive measures should be considered. Objective questionnaires are needed in order to evaluate functional outcomes.PMID:33878936 | DOI:10.1177/19458924211012120 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 21, 2021 Category: ENT & OMF Authors: Jacopo Zocchi Federico Russo Luca Volpi Hassan Ahmed Elhassan Giacomo Pietrobon Alberto Arosio Maurizio Bignami Paolo Castelnuovo Source Type: research

A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis
CONCLUSION: Although benralizumab did not meet the primary efficacy endpoint, reductions of nasal polyp scores were seen in the benralizumab group compared with the placebo group over the whole study period, especially in patients with high levels of blood eosinophils.PMID:33840229 | DOI:10.1177/19458924211009429 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 12, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Daiya Asaka Yoshitaka Okamoto Tetsuo Himi Shinichi Haruna Naohiro Yoshida Kenji Kondo Mamoru Yoshikawa Yasunori Sakuma Kunihiko Shibata Motohiko Suzuki Masayoshi Kobayashi Ryo Kawata Kenzo Tsuzuki Mitsuhiro Okano Takaya Higaki Sachio T Source Type: research

A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis
CONCLUSION: Although benralizumab did not meet the primary efficacy endpoint, reductions of nasal polyp scores were seen in the benralizumab group compared with the placebo group over the whole study period, especially in patients with high levels of blood eosinophils.PMID:33840229 | DOI:10.1177/19458924211009429 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 12, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Daiya Asaka Yoshitaka Okamoto Tetsuo Himi Shinichi Haruna Naohiro Yoshida Kenji Kondo Mamoru Yoshikawa Yasunori Sakuma Kunihiko Shibata Motohiko Suzuki Masayoshi Kobayashi Ryo Kawata Kenzo Tsuzuki Mitsuhiro Okano Takaya Higaki Sachio T Source Type: research

A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis
CONCLUSION: Although benralizumab did not meet the primary efficacy endpoint, reductions of nasal polyp scores were seen in the benralizumab group compared with the placebo group over the whole study period, especially in patients with high levels of blood eosinophils.PMID:33840229 | DOI:10.1177/19458924211009429 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 12, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Daiya Asaka Yoshitaka Okamoto Tetsuo Himi Shinichi Haruna Naohiro Yoshida Kenji Kondo Mamoru Yoshikawa Yasunori Sakuma Kunihiko Shibata Motohiko Suzuki Masayoshi Kobayashi Ryo Kawata Kenzo Tsuzuki Mitsuhiro Okano Takaya Higaki Sachio T Source Type: research

A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis
CONCLUSION: Although benralizumab did not meet the primary efficacy endpoint, reductions of nasal polyp scores were seen in the benralizumab group compared with the placebo group over the whole study period, especially in patients with high levels of blood eosinophils.PMID:33840229 | DOI:10.1177/19458924211009429 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 12, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Daiya Asaka Yoshitaka Okamoto Tetsuo Himi Shinichi Haruna Naohiro Yoshida Kenji Kondo Mamoru Yoshikawa Yasunori Sakuma Kunihiko Shibata Motohiko Suzuki Masayoshi Kobayashi Ryo Kawata Kenzo Tsuzuki Mitsuhiro Okano Takaya Higaki Sachio T Source Type: research

A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis
CONCLUSION: Although benralizumab did not meet the primary efficacy endpoint, reductions of nasal polyp scores were seen in the benralizumab group compared with the placebo group over the whole study period, especially in patients with high levels of blood eosinophils.PMID:33840229 | DOI:10.1177/19458924211009429 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 12, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Daiya Asaka Yoshitaka Okamoto Tetsuo Himi Shinichi Haruna Naohiro Yoshida Kenji Kondo Mamoru Yoshikawa Yasunori Sakuma Kunihiko Shibata Motohiko Suzuki Masayoshi Kobayashi Ryo Kawata Kenzo Tsuzuki Mitsuhiro Okano Takaya Higaki Sachio T Source Type: research

A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis
CONCLUSION: Although benralizumab did not meet the primary efficacy endpoint, reductions of nasal polyp scores were seen in the benralizumab group compared with the placebo group over the whole study period, especially in patients with high levels of blood eosinophils.PMID:33840229 | DOI:10.1177/19458924211009429 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 12, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Daiya Asaka Yoshitaka Okamoto Tetsuo Himi Shinichi Haruna Naohiro Yoshida Kenji Kondo Mamoru Yoshikawa Yasunori Sakuma Kunihiko Shibata Motohiko Suzuki Masayoshi Kobayashi Ryo Kawata Kenzo Tsuzuki Mitsuhiro Okano Takaya Higaki Sachio T Source Type: research

A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis
CONCLUSION: Although benralizumab did not meet the primary efficacy endpoint, reductions of nasal polyp scores were seen in the benralizumab group compared with the placebo group over the whole study period, especially in patients with high levels of blood eosinophils.PMID:33840229 | DOI:10.1177/19458924211009429 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 12, 2021 Category: ENT & OMF Authors: Tetsuji Takabayashi Daiya Asaka Yoshitaka Okamoto Tetsuo Himi Shinichi Haruna Naohiro Yoshida Kenji Kondo Mamoru Yoshikawa Yasunori Sakuma Kunihiko Shibata Motohiko Suzuki Masayoshi Kobayashi Ryo Kawata Kenzo Tsuzuki Mitsuhiro Okano Takaya Higaki Sachio T Source Type: research

High Histamine Control Concentration Leads to False Negative Allergy Skin Testing
Am J Rhinol Allergy. 2021 Apr 7:19458924211008685. doi: 10.1177/19458924211008685. Online ahead of print.ABSTRACTBACKGROUND: Allergy skin test reliability depends on the reagents and controls selected. Histamine is used at 1 mg/ml and 6 mg/ml concentration but few studies address the rationale for selecting one versus the other and how this may impact diagnostic accuracy.OBJECTIVE: To determine the rate of false negative allergen skin tests responses between UniTest PC (using the 1 mg/mL histamine) and Quintip devices (using 6 mg/mL) for 4 common aeroallergens.METHODS: Subjects aged 18-65 with symptoms of allergy to cat an...
Source: American Journal of Rhinology and Allergy - April 8, 2021 Category: ENT & OMF Authors: Amulya Amirneni Jody Tversky Source Type: research

High Histamine Control Concentration Leads to False Negative Allergy Skin Testing
Am J Rhinol Allergy. 2021 Apr 7:19458924211008685. doi: 10.1177/19458924211008685. Online ahead of print.ABSTRACTBACKGROUND: Allergy skin test reliability depends on the reagents and controls selected. Histamine is used at 1 mg/ml and 6 mg/ml concentration but few studies address the rationale for selecting one versus the other and how this may impact diagnostic accuracy.OBJECTIVE: To determine the rate of false negative allergen skin tests responses between UniTest PC (using the 1 mg/mL histamine) and Quintip devices (using 6 mg/mL) for 4 common aeroallergens.METHODS: Subjects aged 18-65 with symptoms of allergy to cat an...
Source: American Journal of Rhinology and Allergy - April 8, 2021 Category: ENT & OMF Authors: Amulya Amirneni Jody Tversky Source Type: research

High Histamine Control Concentration Leads to False Negative Allergy Skin Testing
Am J Rhinol Allergy. 2021 Apr 7:19458924211008685. doi: 10.1177/19458924211008685. Online ahead of print.ABSTRACTBACKGROUND: Allergy skin test reliability depends on the reagents and controls selected. Histamine is used at 1 mg/ml and 6 mg/ml concentration but few studies address the rationale for selecting one versus the other and how this may impact diagnostic accuracy.OBJECTIVE: To determine the rate of false negative allergen skin tests responses between UniTest PC (using the 1 mg/mL histamine) and Quintip devices (using 6 mg/mL) for 4 common aeroallergens.METHODS: Subjects aged 18-65 with symptoms of allergy to cat an...
Source: American Journal of Rhinology and Allergy - April 8, 2021 Category: ENT & OMF Authors: Amulya Amirneni Jody Tversky Source Type: research

High Histamine Control Concentration Leads to False Negative Allergy Skin Testing
Am J Rhinol Allergy. 2021 Apr 7:19458924211008685. doi: 10.1177/19458924211008685. Online ahead of print.ABSTRACTBACKGROUND: Allergy skin test reliability depends on the reagents and controls selected. Histamine is used at 1 mg/ml and 6 mg/ml concentration but few studies address the rationale for selecting one versus the other and how this may impact diagnostic accuracy.OBJECTIVE: To determine the rate of false negative allergen skin tests responses between UniTest PC (using the 1 mg/mL histamine) and Quintip devices (using 6 mg/mL) for 4 common aeroallergens.METHODS: Subjects aged 18-65 with symptoms of allergy to cat an...
Source: American Journal of Rhinology and Allergy - April 8, 2021 Category: ENT & OMF Authors: Amulya Amirneni Jody Tversky Source Type: research

COVID-19-Induced Anosmia and Ageusia Are Associated With Younger Age and Lower Blood Eosinophil Counts
CONCLUSION: Anosmia and ageusia were more common among younger patients and those with lower blood eosinophil counts. Ageusia was less commonly reported among men, and time to taste recovery was earlier among both men and Latinos.PMID:33813917 | DOI:10.1177/19458924211004800 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 5, 2021 Category: ENT & OMF Authors: Esha Sehanobish Mali Barbi Valerie Fong Meryl Kravitz Denise Sanchez Tejera Mohammad Asad Cynthia Matsumura Denisa Ferastraoaru Meaghan O'Neill Merhunisa Karagic Nadeem Akbar Danielle M Bottalico Viraj Patel Alexandre Peshansky Mahendra Rangareddy Golda H Source Type: research

COVID-19-Induced Anosmia and Ageusia Are Associated With Younger Age and Lower Blood Eosinophil Counts
CONCLUSION: Anosmia and ageusia were more common among younger patients and those with lower blood eosinophil counts. Ageusia was less commonly reported among men, and time to taste recovery was earlier among both men and Latinos.PMID:33813917 | DOI:10.1177/19458924211004800 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 5, 2021 Category: ENT & OMF Authors: Esha Sehanobish Mali Barbi Valerie Fong Meryl Kravitz Denise Sanchez Tejera Mohammad Asad Cynthia Matsumura Denisa Ferastraoaru Meaghan O'Neill Merhunisa Karagic Nadeem Akbar Danielle M Bottalico Viraj Patel Alexandre Peshansky Mahendra Rangareddy Golda H Source Type: research

COVID-19-Induced Anosmia and Ageusia Are Associated With Younger Age and Lower Blood Eosinophil Counts
CONCLUSION: Anosmia and ageusia were more common among younger patients and those with lower blood eosinophil counts. Ageusia was less commonly reported among men, and time to taste recovery was earlier among both men and Latinos.PMID:33813917 | DOI:10.1177/19458924211004800 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - April 5, 2021 Category: ENT & OMF Authors: Esha Sehanobish Mali Barbi Valerie Fong Meryl Kravitz Denise Sanchez Tejera Mohammad Asad Cynthia Matsumura Denisa Ferastraoaru Meaghan O'Neill Merhunisa Karagic Nadeem Akbar Danielle M Bottalico Viraj Patel Alexandre Peshansky Mahendra Rangareddy Golda H Source Type: research

Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach
CONCLUSIONS: The MTPA obviates the need for PPF dissection and simplifies access to the lateral sphenoid recess while minimizing postoperative morbidity. This approach should be considered for accessing meningoencephaloceles and other benign lesions in this challenging location.PMID:33761785 | DOI:10.1177/19458924211003813 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Satyan B Sreenath Dennis M Tang Jo ão Paulo De Almeida Pranay Soni Troy D Woodard Pablo F Recinos Varun R Kshettry Raj Sindwani Source Type: research

Immunosuppressive Regulation of Dendritic Cells and T Cells in Allergic Rhinitis by Semaphorin 3A
CONCLUSION: AR presented with low expression of Sema3A in nasal mucosa, and Sema3A could decrease DC maturation, T cell proliferation, and Treg polarization.PMID:33761786 | DOI:10.1177/19458924211005592 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Honghui Liu Jinye Xia Yu Chen Jingang Ai Tiansheng Wang Guolin Tan Source Type: research

Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach
CONCLUSIONS: The MTPA obviates the need for PPF dissection and simplifies access to the lateral sphenoid recess while minimizing postoperative morbidity. This approach should be considered for accessing meningoencephaloceles and other benign lesions in this challenging location.PMID:33761785 | DOI:10.1177/19458924211003813 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Satyan B Sreenath Dennis M Tang Jo ão Paulo De Almeida Pranay Soni Troy D Woodard Pablo F Recinos Varun R Kshettry Raj Sindwani Source Type: research

Immunosuppressive Regulation of Dendritic Cells and T Cells in Allergic Rhinitis by Semaphorin 3A
CONCLUSION: AR presented with low expression of Sema3A in nasal mucosa, and Sema3A could decrease DC maturation, T cell proliferation, and Treg polarization.PMID:33761786 | DOI:10.1177/19458924211005592 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Honghui Liu Jinye Xia Yu Chen Jingang Ai Tiansheng Wang Guolin Tan Source Type: research

Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach
CONCLUSIONS: The MTPA obviates the need for PPF dissection and simplifies access to the lateral sphenoid recess while minimizing postoperative morbidity. This approach should be considered for accessing meningoencephaloceles and other benign lesions in this challenging location.PMID:33761785 | DOI:10.1177/19458924211003813 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Satyan B Sreenath Dennis M Tang Jo ão Paulo De Almeida Pranay Soni Troy D Woodard Pablo F Recinos Varun R Kshettry Raj Sindwani Source Type: research

Immunosuppressive Regulation of Dendritic Cells and T Cells in Allergic Rhinitis by Semaphorin 3A
CONCLUSION: AR presented with low expression of Sema3A in nasal mucosa, and Sema3A could decrease DC maturation, T cell proliferation, and Treg polarization.PMID:33761786 | DOI:10.1177/19458924211005592 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Honghui Liu Jinye Xia Yu Chen Jingang Ai Tiansheng Wang Guolin Tan Source Type: research

Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach
CONCLUSIONS: The MTPA obviates the need for PPF dissection and simplifies access to the lateral sphenoid recess while minimizing postoperative morbidity. This approach should be considered for accessing meningoencephaloceles and other benign lesions in this challenging location.PMID:33761785 | DOI:10.1177/19458924211003813 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Satyan B Sreenath Dennis M Tang Jo ão Paulo De Almeida Pranay Soni Troy D Woodard Pablo F Recinos Varun R Kshettry Raj Sindwani Source Type: research

Immunosuppressive Regulation of Dendritic Cells and T Cells in Allergic Rhinitis by Semaphorin 3A
CONCLUSION: AR presented with low expression of Sema3A in nasal mucosa, and Sema3A could decrease DC maturation, T cell proliferation, and Treg polarization.PMID:33761786 | DOI:10.1177/19458924211005592 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Honghui Liu Jinye Xia Yu Chen Jingang Ai Tiansheng Wang Guolin Tan Source Type: research

Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach
CONCLUSIONS: The MTPA obviates the need for PPF dissection and simplifies access to the lateral sphenoid recess while minimizing postoperative morbidity. This approach should be considered for accessing meningoencephaloceles and other benign lesions in this challenging location.PMID:33761785 | DOI:10.1177/19458924211003813 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Satyan B Sreenath Dennis M Tang Jo ão Paulo De Almeida Pranay Soni Troy D Woodard Pablo F Recinos Varun R Kshettry Raj Sindwani Source Type: research

Immunosuppressive Regulation of Dendritic Cells and T Cells in Allergic Rhinitis by Semaphorin 3A
CONCLUSION: AR presented with low expression of Sema3A in nasal mucosa, and Sema3A could decrease DC maturation, T cell proliferation, and Treg polarization.PMID:33761786 | DOI:10.1177/19458924211005592 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Honghui Liu Jinye Xia Yu Chen Jingang Ai Tiansheng Wang Guolin Tan Source Type: research

Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach
CONCLUSIONS: The MTPA obviates the need for PPF dissection and simplifies access to the lateral sphenoid recess while minimizing postoperative morbidity. This approach should be considered for accessing meningoencephaloceles and other benign lesions in this challenging location.PMID:33761785 | DOI:10.1177/19458924211003813 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Satyan B Sreenath Dennis M Tang Jo ão Paulo De Almeida Pranay Soni Troy D Woodard Pablo F Recinos Varun R Kshettry Raj Sindwani Source Type: research

Immunosuppressive Regulation of Dendritic Cells and T Cells in Allergic Rhinitis by Semaphorin 3A
CONCLUSION: AR presented with low expression of Sema3A in nasal mucosa, and Sema3A could decrease DC maturation, T cell proliferation, and Treg polarization.PMID:33761786 | DOI:10.1177/19458924211005592 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Honghui Liu Jinye Xia Yu Chen Jingang Ai Tiansheng Wang Guolin Tan Source Type: research

Simplifying Access to the Lateral Sphenoid Recess: A Modification of the Transpterygoid Approach
CONCLUSIONS: The MTPA obviates the need for PPF dissection and simplifies access to the lateral sphenoid recess while minimizing postoperative morbidity. This approach should be considered for accessing meningoencephaloceles and other benign lesions in this challenging location.PMID:33761785 | DOI:10.1177/19458924211003813 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - March 25, 2021 Category: ENT & OMF Authors: Satyan B Sreenath Dennis M Tang Jo ão Paulo De Almeida Pranay Soni Troy D Woodard Pablo F Recinos Varun R Kshettry Raj Sindwani Source Type: research