Effect of Neurokinin-1 Receptor Knockdown on the Expression of RANTES in Allergic Rhinitis
Am J Rhinol Allergy. 2023 Jul 31:19458924231191012. doi: 10.1177/19458924231191012. Online ahead of print.ABSTRACTBACKGROUND: Neurokinin-1 receptor (NK-1R) and normal T cell expressed and secreted (RANTES) have been shown to play important roles in allergic rhinitis (AR). However, whether the regulating effect of NK-1R in AR is achieved via RANTES remains unknown.METHODS: In the present study, Sprague-Dawley rats were sensitized and challenged with ovalbumin to make AR models. During the challenge period, the rats were treated intranasally with NK-1R-specific small interfering RNA (siRNA) for NKR group, negative siRNA for ...
Source: American Journal of Rhinology and Allergy - August 1, 2023 Category: ENT & OMF Authors: Hong Wang Jing Wu Ruxin Zhang Source Type: research

Bringing Together Multiple Perspectives in Rhinology and Allergy
Am J Rhinol Allergy. 2023 Sep;37(5):516-517. doi: 10.1177/19458924231188958.NO ABSTRACTPMID:37526105 | DOI:10.1177/19458924231188958 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 1, 2023 Category: ENT & OMF Authors: Sarita U Patil Source Type: research

Effect of Neurokinin-1 Receptor Knockdown on the Expression of RANTES in Allergic Rhinitis
Am J Rhinol Allergy. 2023 Jul 31:19458924231191012. doi: 10.1177/19458924231191012. Online ahead of print.ABSTRACTBACKGROUND: Neurokinin-1 receptor (NK-1R) and normal T cell expressed and secreted (RANTES) have been shown to play important roles in allergic rhinitis (AR). However, whether the regulating effect of NK-1R in AR is achieved via RANTES remains unknown.METHODS: In the present study, Sprague-Dawley rats were sensitized and challenged with ovalbumin to make AR models. During the challenge period, the rats were treated intranasally with NK-1R-specific small interfering RNA (siRNA) for NKR group, negative siRNA for ...
Source: American Journal of Rhinology and Allergy - August 1, 2023 Category: ENT & OMF Authors: Hong Wang Jing Wu Ruxin Zhang Source Type: research

Bringing Together Multiple Perspectives in Rhinology and Allergy
Am J Rhinol Allergy. 2023 Sep;37(5):516-517. doi: 10.1177/19458924231188958.NO ABSTRACTPMID:37526105 | DOI:10.1177/19458924231188958 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 1, 2023 Category: ENT & OMF Authors: Sarita U Patil Source Type: research

Systematic Review of Protein Biomarkers in Adult Patients With Chronic Rhinosinusitis
CONCLUSION: We have identified numerous potential biomarkers to differentiate a range of CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.We registered this study in PROSPERO (CRD42022302787).PMID:37491901 | DOI:10.1177/19458924231190568 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 26, 2023 Category: ENT & OMF Authors: Shyam A Gokani Andreas Espehana Ana C Pratas Louis Luke Ekta Sharma Jennifer Mattock Jelena Gavrilovic Allan Clark Tom Wileman Carl M Philpott Source Type: research

Systematic Review of Protein Biomarkers in Adult Patients With Chronic Rhinosinusitis
CONCLUSION: We have identified numerous potential biomarkers to differentiate a range of CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.We registered this study in PROSPERO (CRD42022302787).PMID:37491901 | DOI:10.1177/19458924231190568 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 26, 2023 Category: ENT & OMF Authors: Shyam A Gokani Andreas Espehana Ana C Pratas Louis Luke Ekta Sharma Jennifer Mattock Jelena Gavrilovic Allan Clark Tom Wileman Carl M Philpott Source Type: research

Systematic Review of Protein Biomarkers in Adult Patients With Chronic Rhinosinusitis
CONCLUSION: We have identified numerous potential biomarkers to differentiate a range of CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.We registered this study in PROSPERO (CRD42022302787).PMID:37491901 | DOI:10.1177/19458924231190568 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 26, 2023 Category: ENT & OMF Authors: Shyam A Gokani Andreas Espehana Ana C Pratas Louis Luke Ekta Sharma Jennifer Mattock Jelena Gavrilovic Allan Clark Tom Wileman Carl M Philpott Source Type: research

Systematic Review of Protein Biomarkers in Adult Patients With Chronic Rhinosinusitis
CONCLUSION: We have identified numerous potential biomarkers to differentiate a range of CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.We registered this study in PROSPERO (CRD42022302787).PMID:37491901 | DOI:10.1177/19458924231190568 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 26, 2023 Category: ENT & OMF Authors: Shyam A Gokani Andreas Espehana Ana C Pratas Louis Luke Ekta Sharma Jennifer Mattock Jelena Gavrilovic Allan Clark Tom Wileman Carl M Philpott Source Type: research

Systematic Review of Protein Biomarkers in Adult Patients With Chronic Rhinosinusitis
CONCLUSION: We have identified numerous potential biomarkers to differentiate a range of CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.We registered this study in PROSPERO (CRD42022302787).PMID:37491901 | DOI:10.1177/19458924231190568 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 26, 2023 Category: ENT & OMF Authors: Shyam A Gokani Andreas Espehana Ana C Pratas Louis Luke Ekta Sharma Jennifer Mattock Jelena Gavrilovic Allan Clark Tom Wileman Carl M Philpott Source Type: research

The Effect of Corticosteroids on Sinus Microbiota in Chronic Rhinosinusitis Patients with Nasal Polyposis
CONCLUSION: In this pilot study, both treatment options were effective to improve symptoms in the short-term but not in the long-term, and were not linked to any clear sinus microbiota response. As a result, this study supports the avoidance of systemic antibiotics without evidence of active infection.PMID:37475202 | DOI:10.1177/19458924231183848 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 21, 2023 Category: ENT & OMF Authors: Yousif Alammar Simon Rousseau Martin Desrosiers Marc A Tewfik Source Type: research

The Effect of Corticosteroids on Sinus Microbiota in Chronic Rhinosinusitis Patients with Nasal Polyposis
CONCLUSION: In this pilot study, both treatment options were effective to improve symptoms in the short-term but not in the long-term, and were not linked to any clear sinus microbiota response. As a result, this study supports the avoidance of systemic antibiotics without evidence of active infection.PMID:37475202 | DOI:10.1177/19458924231183848 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 21, 2023 Category: ENT & OMF Authors: Yousif Alammar Simon Rousseau Martin Desrosiers Marc A Tewfik Source Type: research

The Effect of Corticosteroids on Sinus Microbiota in Chronic Rhinosinusitis Patients with Nasal Polyposis
CONCLUSION: In this pilot study, both treatment options were effective to improve symptoms in the short-term but not in the long-term, and were not linked to any clear sinus microbiota response. As a result, this study supports the avoidance of systemic antibiotics without evidence of active infection.PMID:37475202 | DOI:10.1177/19458924231183848 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 21, 2023 Category: ENT & OMF Authors: Yousif Alammar Simon Rousseau Martin Desrosiers Marc A Tewfik Source Type: research

The Effect of Corticosteroids on Sinus Microbiota in Chronic Rhinosinusitis Patients with Nasal Polyposis
CONCLUSION: In this pilot study, both treatment options were effective to improve symptoms in the short-term but not in the long-term, and were not linked to any clear sinus microbiota response. As a result, this study supports the avoidance of systemic antibiotics without evidence of active infection.PMID:37475202 | DOI:10.1177/19458924231183848 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 21, 2023 Category: ENT & OMF Authors: Yousif Alammar Simon Rousseau Martin Desrosiers Marc A Tewfik Source Type: research

The Effect of Corticosteroids on Sinus Microbiota in Chronic Rhinosinusitis Patients with Nasal Polyposis
CONCLUSION: In this pilot study, both treatment options were effective to improve symptoms in the short-term but not in the long-term, and were not linked to any clear sinus microbiota response. As a result, this study supports the avoidance of systemic antibiotics without evidence of active infection.PMID:37475202 | DOI:10.1177/19458924231183848 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 21, 2023 Category: ENT & OMF Authors: Yousif Alammar Simon Rousseau Martin Desrosiers Marc A Tewfik Source Type: research

Crocin Inhibits the Type 2 Inflammatory Response Produced by ILC2s in Eosinophilic Nasal Polyps
CONCLUSION: Crocin inhibited type 2 inflammation induced by ILC2 activation at low concentrations via inhibiting the activation of NF-κB.PMID:37424236 | DOI:10.1177/19458924231185296 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - July 10, 2023 Category: ENT & OMF Authors: Xu Xiaodong Li Tao Liu Jianmin Zhou Jing Zhong Bing Du Jintao Claus Bachert Ba Luo Source Type: research