Extracellular Vesicle ‐Contained Thrombospondin 1 Retards Age‐Related Degenerative Tendinopathy by Rejuvenating Tendon Stem/Progenitor Cell Senescence
This study demonstrates that extracellular vesicles (EVs) from young tendon stem/progenitor cells (TSPCs) can rejuvenate senescent TSPCs by re-establishing autophagy through the inhibition of PI3K/AKT pathway, which is mainly mediated by EV-contained thrombospondin 1. This process alleviates cellular senescence and promotes tendon regeneration in aged rats, offering a promising treatment for age-related degenerative tendinopathy. AbstractAdvanced age is a major risk factor for age-related degenerative tendinopathy. During aging, tendon stem/progenitor cell (TSPC) function declines owing to the transition from a normal quie...
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Zhuochang Cai, Zhiyi Xin, Haoyuan Wang, Chongyang Wang, Xudong Liu Tags: Research Article Source Type: research

A 3.2  V Binary Layered Oxide Cathode for Potassium‐Ion Batteries
P3-type K0.5Ni1/3Mn2/3O2 layered oxide is introduced as a potential cathode material for potassium-ion batteries. Involving a solid solution mechanism, it works as a 3.2  V cathode delivering a reversible capacity of 80–100 mAh.g−1 with a stable performance at ambient as well as high temperature (40 –50 °C). It can be harnessed for stationary energy storage. AbstractPotassium-ion batteries (KIBs) can offer high energy density, cyclability, and operational safety while being economical due to the natural abundance of potassium. Utilizing graphite as an anode, suitable cathodes can realize full cells. Searching for...
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Pawan Kumar Jha, Shubham Kumar Parate, Krishnakanth Sada, Kazuki Yoshii, Titus Masese, Pavan Nukala, Gopalakrishnan Sai Gautam, Val érie Pralong, Maximilian Fichtner, Prabeer Barpanda Tags: Research Article Source Type: research

Upgrading Gel Electrolytes Through Electrostatic ‐Induced Dual‐Salt Paradigm for Superior Zn‐Ion Battery Performance
An electrostatic-induced dual-salt paradigm is proposed to upgrade gel electrolytes, which improves the ion transport along with mechanical properties of gel electrolytes, and stabilizes Zn anodes. The dual-salt gel electrolyte enables excellent reversibility of the Zn anode at both room and low temperatures. Furthermore, this work also provides a new direction in gel electrolyte design for Zn-ion batteries. AbstractGel electrolytes are gaining attention for rechargeable Zn-ion batteries because of their high safety, high flexibility, and excellent comprehensive electrochemical performances. However, current gel electrolyt...
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Jianyang Wu, Mengchao Li, Xuan Ding, Zheming Chen, Jing Luo, Qiaoli Zhang, Yanbin Qiu, Qian Wang, Wen Liu, Chengkai Yang Tags: Research Article Source Type: research

In Situ Symbiosis of Cerium Oxide Nanophase for Enhancing the Oxygen Electrocatalysis Performance of Single ‐Atom Fe─N─C Catalyst with Prolonged Stability for Zinc–Air Batteries
This study provides insights for optimizing SAC-based electrocatalysts with high activity and stability. (Source: Small)
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Hao Luo, Jiajun Wang, Shiyu Zhang, Buwei Sun, Zanyu Chen, Xixi Ren, Ziyi Luo, Xiaopeng Han, Wenbin Hu Tags: Research Article Source Type: research

Nanoparticle Surfactants at Complex Emulsion Interfaces
A simple and efficient strategy to stabilize complex emulsions with cellulose nanocrystal surfactants and fluorosurfactants is developed. By using the concentration or pH as the stimulus, reconfiguration of complex emulsions from encapsulated to Janus structures can be achieved. With complex emulsions serving as templates, particles of different shapes including hollow, semi-spherical, and spherical can be synthesized on large scale. AbstractUsing nanoparticle surfactants to stabilize the liquid-liquid interface has attracted significant attention for developing all-liquid constructs including emulsions and liquid devices....
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Yuzheng Luo, Kaijuan Li, Jiaqiu Luo, Yunhui Wen, Shaowei Shi Tags: Research Article Source Type: research

Coordination Engineering of Carbon Dots and Mn in Co ‐Based Phosphides for Highly Efficient Seawater Splitting at Ampere‐Level Current Density
This study sheds light on the development of highly effective and stable catalysts for large-scale seawater electrolysis. (Source: Small)
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Tingting Fang, Xin Yu, Xingzhuo Han, Juan Gao, Yurong Ma Tags: Research Article Source Type: research

Performance of Nitrogen ‐Doped Carbon Nanoparticles Carrying FeNiCu as Bifunctional Electrocatalyst for Rechargeable Zinc‐Air Battery
This study presents a new method for achieving high-performance, low-cost ZABs via trimetallic single-atom doping. (Source: Small)
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Qiao Guo, Rui Yuan, Yutong Zhao, Ying Yu, Jie Fu, Longsheng Cao Tags: Research Article Source Type: research

Vanadium Single Atoms Embedded in MoS2 Enabled Gut ‐Brain Axis Neurotransmitter Detection at pM Levels
In this work, the V-doped MoS2 by a two-step synthesis method is successfully obtained. Differential pulse voltammetry test results show that V-SACs are able to achieve the serotonin lowest detection limit down to 1  pM. There are two linear regions (1 pM ∼100 pM and 100 pM ∼100 µM), and the sensing sites are V-SACs and S-bonding on the surface, respectively. AbstractThe detection of monoamine neurotransmitters is of paramount importance as the neurotransmitters are the chemical messengers regulating the gut-brain axis (GBA). It requires real-time, ultrasensitive, and selective sensing of the neurotransmitters in...
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Linxuan Sun, Hengyue Xu, Yichao Bai, Liang Chang, Jianxiang Gao, Mingchuang Zhao, Arthur Tran Huang, Lan Ma, Yu Lei, Feiyu Kang, Mauricio Terrones Tags: Research Article Source Type: research

Programmable Optoelectronic Synaptic Transistors Based on MoS2/Ta2NiS5 Heterojunction for Energy ‐Efficient Neuromorphic Optical Operation
This article presents an all-2D vdW heterojunction-based programmable optoelectronic synaptic transistor. The device implements reconfigurable, multilevel NVM states through sequential modulation of multiple optical and electrical stimuli to achieve broadband, energy-efficient, hetero-synaptic functionality, including biological emotions, withdrawal reactions, and logic functions. AbstractThe optoelectronic synaptic transistors with various functions, broad spectral perception, and low power consumption are an urgent need for the development of advanced optical neural network systems. However, it remains a great challenge ...
Source: Small - May 23, 2024 Category: Nanotechnology Authors: Junru An, Nan Zhang, Fan Tan, Xingyu Zhao, Chunlu Chang, Mario Lanza, Shaojuan Li Tags: Research Article Source Type: research

Recent Progress on Dominant Sulfide ‐Type Solid‐State Na Superionic Conductors for Solid‐State Sodium Batteries
This article provides a comprehensive update on the synthesis, structure, and properties of three dominant sulfide-based Na-ion conductors (Na3PS4, Na3SbS4, and Na11Sn2PS12), and their families that have a variety of anion and cation doping. Additionally, the interface stability of these sulfide electrolytes toward the anode is reviewed, as well as the electrochemical performance of solid-state Na batteries based on different types of cathode materials (metal sulfides, oxides, and organics). Finally, the perspective and outlook for the development and practical utilization of sulfide-based SE in solid-state batteries are d...
Source: Small - May 22, 2024 Category: Nanotechnology Authors: Xiaolin Guo, Selim Halacoglu, Yan Chen, Hui Wang Tags: Review Source Type: research

Cascaded Nanozyme Based pH ‐Responsive Oxygenation for Targeted Eradication of Resistant Helicobacter Pylori
A four-in-one nanozyme is reported with the cascaded SOD-, CAT-, POD-, and OXD-mimicking activities. Ferrocene is novelly doped in Prussian blue and used as the core and Co3O4 NPs are modified to provide multifunctional hybrid cascaded nanozyme activities. With the encapsulation of chitosan, this nanozyme exhibits excellent therapeutic potential forH. pylori infections in vitro and in vivo. AbstractNanozymes, as substitutes for natural enzymes, are constructed as cascade catalysis systems for biomedical applications due to their inherent catalytic properties, high stability, tunable physicochemical properties, and environm...
Source: Small - May 22, 2024 Category: Nanotechnology Authors: Yue Tong, Qian Liu, Hongli Fu, Mengfan Han, Hanchen Zhu, Kun Yang, Le Xu, Meng Meng, Yongmei Yin, Rimo Xi Tags: Research Article Source Type: research

Advances in Nanomaterials for Immunotherapeutic Improvement of Cancer Chemotherapy
Schematic illustration of the causes for the inefficiency of immuno-stimulative effect of chemotherapy (ISECT), strategies, and specific nanomaterials for ISECT improvement. AbstractImmuno-stimulative  effect of chemotherapy (ISECT) is recognized as a potential alternative to conventional immunotherapies, however, the clinical application is constrained by its inefficiency. Metronomic chemotherapy, though designed to overcome these limitations, offers inconsistent results, with effectiveness var ying based on cancer types, stages, and patient-specific factors. In parallel, a wealth of preclinical nanomaterials holds consi...
Source: Small - May 22, 2024 Category: Nanotechnology Authors: Jie Liu, Bei Li, Li Li, Xin Ming, Zhi Ping Xu Tags: Review Source Type: research

Surface ‐Integrating Oxygen Vacancy and CuxO Nanodots Enabling Synergistic Electric Field and Dual Catalytic Sites Boosting CO2 Photoreduction
Surface-integrated oxygen vacancies (Ov) and CuxO (1<x< 2) nanodots below 10 nm enable the formation of enhanced internal electric field and cooperatively reduce the surface work function of Bi2MoO6, accelerating the separation of photocharge carriers. They also serve as dual catalytic sites to strengthen the activation CO2 into *CO2, considerably boosting the CO2 conversion process over Bi2MoO6, thus resulting in a remarkable CO generation rate increase of ≈15 times. AbstractHigh carrier separation efficiency and rapid surface catalytic reaction are crucial for enhancing catalytic CO2 photoreduction reaction. Here...
Source: Small - May 22, 2024 Category: Nanotechnology Authors: Shuguan Li, Jingcong Hu, Fang Chen, Shengqi Chu, Ruofei Tang, Shengyao Wang, Qi An, Hongwei Huang Tags: Research Article Source Type: research

Robust Amide ‐Linked Fluorinated Covalent Organic Framework for Long‐Term Oxygen Reduction Reaction Electrocatalysis
In this work, the post-synthetic modification of the linkage of a covalent organic framework used as a catalyst is reported for the electrogeneration of hydrogen peroxide. This conversion from imine to amide enhances the robustness of the framework as well as its activity and overall performance as an electrocatalyst. AbstractThe high energy demand of the evolving world opens the door to develop more sustainable and environmentally friendly energy sources. Oxygen reduction reaction (ORR) is a promising candidate, being the 2e− pathway of great interest for the green production of hydrogen peroxide. Metal-free covalent or...
Source: Small - May 22, 2024 Category: Nanotechnology Authors: Miguel Jim énez‐Duro, Emiliano Martínez‐Periñán, Marcos Martínez‐Fernández, José I. Martínez, Encarnación Lorenzo, José L. Segura Tags: Research Article Source Type: research

Temperature Induced Reversible Switching of the Magnetic Anisotropy in a Neodymium Complex Adsorbed on Graphite
Nd(trensal) is a mononuclear lanthanide complex which undergoes a switch of the magnetic anisotropy from easy-axis to easy-plane modifying the temperature. When deposited as an ultra-thin film over highly ordered pyrolityc graphtie this phenomenon is retained. AbstractControlling the magnetic anisotropy of molecular layers assembled on a surface is one of the challenges that needs to be addressed to create the next-generation spintronic devices. Recently, metal complexes that show a reversible solid-state switch of their magnetic anisotropy in response to physical stimuli, such as temperature and magnetic field, have been ...
Source: Small - May 22, 2024 Category: Nanotechnology Authors: Leonardo Tacconi, Sofie S. Leiszner, Matteo Briganti, Giuseppe Cucinotta, Edwige Otero, Matteo Mannini, Mauro Perfetti Tags: Research Article Source Type: research