The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF- κB and Akt/VEGF signaling in CCl4-induced pancreas damage in rats.
CONCLUSIONS: These findings reveal that EA decreases pancreas tissue injury in rats and that EA may also be used as a drug against pancreas tissue injury in the future. PMID: 33455449 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 21, 2021 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Lactoferrin suppresses LPS-induced expression of HMGB1, microRNA 155, 146, and TLR4/MyD88/NF- кB pathway in RAW264.7 cells.
CONCLUSIONS: Altogether, these findings provide LF as a prominent anti-inflammatory agent that could modulate HMGB1, mmu-mir-155, mmu-mir-146a, and TLR4/MyD88/NF-кB pathway. PMID: 33435756 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 14, 2021 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Hecogenin and fluticasone combination attenuates TNBS-induced ulcerative colitis in rats via downregulation of pro-inflammatory mediators and oxidative stress.
CONCLUSION: Thus, HG and HG + FC combination could change the pathogenesis of the disease and may be a potential therapeutic target for the treatment of ulcerative colitis by a reduction in dose in conjunction with FC to prevent the persistent adverse effects associated with FC. PMID: 33435764 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 14, 2021 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Protective effect of the intravenous anesthetic propofol against a local inflammation in the mouse carrageenan-induced air pouch model.
Conclusion: Propofol has an anti-inflammatory property in the carrageenan-induced mouse air pouch local inflammation model, by inhibiting the production of pro-inflammatory cytokines (TNF-α and IL-6), as well as by inhibiting the production of chemokines (KC and MIP-2), which might be associated with the inhibition of intra-pouch recruitment of white blood cells. PMID: 33423569 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 13, 2021 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Interleukin-39 exacerbates concanavalin A-induced liver injury.
CONCLUSION: Our results suggest that IL-39 can exacerbate ConA-induced hepatitis and may be a therapeutic target in inflammatory liver disease. PMID: 33412981 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 10, 2021 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Mifepristone regulates Tregs function mediated by dendritic cells through suppressing the expression of TGF- β.
CONCLUSION: Therefore, our research provides a theoretical basis for a potentially clinical application of mifepristone as a novel contraceptive. PMID: 33406939 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 8, 2021 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Statins as an adjunctive therapy for COVID-19: the biological and clinical plausibility.
Authors: Kashour T, Halwani R, Arabi YM, Sohail MR, O'Horo JC, Badley AD, Tleyjeh IM Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus disease 2019 (COVID-19) has infected millions of individuals and has claimed hundreds of thousands of human lives worldwide. Patients with underlying cardiovascular conditions are at high risk for SARS-CoV-2 infection, and COVID-19 patients have high incidence of cardiovascular complications such as acute cardiac injury, arrhythmias, heart failure, and thromboembolism. The disease has no approved proven effective therapy and hence ...
Source: Immunopharmacology and Immunotoxicology - January 8, 2021 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Different aspects of convalescent plasma therapy for COVID-19 treatment; a critical review.
Authors: Khadka S, Nisar S, Syed NI, Shrestha DB, Budhathoki P Abstract The novel coronavirus disease (COVID-19) has been declared a pandemic by the World Health Organization (WHO) and is ominously threatening the survival of humankind on the whole planet. With a quick spread of the outbreak from its origin, Wuhan, China, to almost all over the world, it has affected more than seven million people to date, hence it has devastated every part of the infrastructural skeleton of governance. Continuously escalating disease burden and lack of proven therapeutic approaches are mounting challenges to health scientists and ...
Source: Immunopharmacology and Immunotoxicology - December 29, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

MRGPRX2 is critical for clozapine induced pseudo-allergic reactions.
CONCLUSIONS: Our findings demonstrated that clozapine could induce pseudo-allergic reactions and MRGPRX2 might be the critical receptor for it. PMID: 33327824 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Regulatory effect of glutathione on treg/Th17 cell balance in allergic rhinitis patients through inhibiting intracellular autophagy.
CONCLUSION: Glutathione could rescue the imbalance of Treg/Th17 cells by suppressing intracellular autophagy, which might be beneficial to the treatment of AR patients. PMID: 33285073 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 9, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inhibitory activity of narirutin on RBL-2H3 cells degranulation.
Conclusion: Our study suggested that the inhibitory mechanism of narirutin on RBL-2H3 cells degranulation could be related to regulate MAPK, NF-κB and Tyrosine kinase signaling pathway. PMID: 33272043 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 5, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Etidronate down-regulates Toll-like receptor 2 ligand-inducedchemokine production by inhibiting MyD88 expression and NF- κB activation.
CONCLUSION: Etidronate down-regulates IL-8 and MCP-1 production in U937 cells by inhibiting both the expression of MyD88 and activation of NF-κB p65 in the TLR2, but not TLR4, pathway. PMID: 33251898 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 2, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Donepezil protects glycerol-induced acute renal failure through the cholinergic anti-inflammatory and nitric oxide pathway in rats.
CONCLUSIONS: These data indicate that donepezil exerts a protective anti-inflammatory effect during ARF through the cholinergic pathway and Nitric oxide pathway. In addition, this study could provide an opportunity to overcome the effect of surgical cholinergic denervation during kidney transplantation and other injury. PMID: 33183119 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - November 18, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Biochemical and immunological aspects of Covid-19 infection and therapeutical intervention of oral low dose cytokine therapy: A systematic review.
Authors: M R, S S, Jose SP, Rajan S, Thomas S, Jagmag T, Tilwani J Abstract The novel coronavirus (SARS-CoV-2) pandemichas now spread to all corners of the world. It causes severe respiratory syndromes which is one of the leading causes of death. Evidence shows that the novel SARS-CoV-2 has close similarities with other coronaviruses, SARS and MERS. So, SARS-CoV-2 might use the similar mechanisms of these viruses to attack the host cells. The severity of COVID-19 is associated with various factors, one of the major reasons is immune dysregulation or immune suppression. Immunity plays a significant role in maintaini...
Source: Immunopharmacology and Immunotoxicology - October 29, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Discovery of a potential biomarker for immunotherapy of melanoma: PLAC1 as an emerging target.
CONCLUSIONS: Our findings re-inforce the concept of re-expression of embryonic/placental tissue antigens in cancer and highlight the possibility of melanoma targeted therapy by employing anti-PLAC1 antibodies. The data presented here should lead to the future research on targeted immunotherapy of patients with melanoma. PMID: 33106058 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - October 29, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Effects of treatment with hydroxychloroquine on the modulation of Th17/Treg ratio and pregnancy outcomes in women with recurrent implantation failure: clinical trial.
Authors: Sadeghpour S, Ghasemnejad Berenji M, Nazarian H, Ghasemnejad T, Nematollahi MH, Abroon S, Paktinat S, Heidari Khoei H, Ghasemnejad Berenji H, Ghaffari Novin M Abstract The imbalance of Th17/Treg cells has been recently suggested as a new risk factors for recurrent implantation failure (RIF). Furthermore Th17/Treg cells are involved in immune regulation in peripheral blood and endometrial tissue of patients with RIF. In this research, we investigated the effects of Hydroxychloroquine (HCQ) on the level and function of Th17 and Treg cells in women with RIF. It may be possible to improve pregnancy outcomes by...
Source: Immunopharmacology and Immunotoxicology - October 23, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Deciphering Vaccines for COVID-19: Where do we stand TODAY?
Authors: Baviskar T, Raut D, Bhatt LK Abstract Pneumonia of unknown etiology was detected in a few patients in Wuhan City, Hubei Province, China. The causative agent was named as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the World Health Organisation (WHO). The disease caused by this virus was named as a new coronavirus disease: COVID-19. The disease has a global impact affecting more than 200 nations including the USA, India, Brazil, Russia, and Peru are the 5 most severely affected nations. The discovery of the genotype and phenotype of SARS-CoV-2 boosted the global efforts for the devel...
Source: Immunopharmacology and Immunotoxicology - October 20, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Contribution of long chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells - Induction of MDSC by lipid vesicles (liposome).
Conclusions: Immunosuppressive cells induced by this pegylated liposome closely resemble MDSCs, especially B7-H3+ MDSCs. Immunosuppression induction is not a phenomenon specific to this liposome. Accumulation of long chain fatty acid in macrophages by internalization of liposomal nanoparticles might be related to macrophage acquisition of immunosuppressive activity in vivo. PMID: 33070657 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - October 20, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Expression of concern.
Authors: PMID: 33043738 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - October 15, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway.
Conclusions: Vitexin protected melanocytes from oxidative stress by activating MAPK-Nrf2/ARE signaling pathway. Our results suggested that the role of Nrf2/ARE axis in antioxidant defense of melanocytes, and the potential therapeutic strategy for vitiligo. PMID: 33045867 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - October 15, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Nicorandil and Atorvastatin Attenuate Carbon Tetrachloride - Induced Liver Fibrosis in Rats.
Authors: Abdel-Sattar AR, Abo-Saif AA, Aboyoussef AM Abstract The present study aimed to evaluate the possible hepatoprotective effects of nicorandil and atorvastatin against experimentally induced liver fibrosis.Wistar male rats wereassigned tofivegroups;control group, fibrosis group, the remaining three groups received in addition to CCl4, N-acetyl cysteine (300 mg/kg), nicorandil(15 mg/kg) and atorvastatin (20 mg/kg), respectively.Liver fibrosis was induced by intraperitoneal injection of rats with CCl4(2ml/kg), twice weekly for five consecutive weeks.All treatments were administereddaily st...
Source: Immunopharmacology and Immunotoxicology - September 30, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

New perspectives in bronchial asthma: Pathological, immunological alterations, biological targets and pharmacotherapy.
Authors: Mandlik DS, Mandlik SK Abstract Asthma is the most common, long-lasting inflammatory airway disease that affects more than 10% of the world population. It is characterized by bronchial narrowing, airway hyperresponsiveness, vasodilatation, airway edema and stimulation of sensory nerve endings that lead to recurring events of breathlessness, wheezing, chest tightness and coughing. It is the main reason for global morbidity and occurs as a result of the weakening of the immune system in response to exposure to allergens or environmental exposure. In asthma condition, it results in the activation of numerous ...
Source: Immunopharmacology and Immunotoxicology - September 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Immunological effects of AFM1 in experimental subchronic dosing in mice prevented by lactic acid bacteria.
Conclusion: LPBEJ01 was safe and haven't any sign of toxicity. It can be used as an additive for AFM1-detoxification contamination in the food chain in countries suffers from this problem. PMID: 32938251 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Immunohistochemical Analysis of Protective Effects of Maternal Fingolimod on the Placenta and Fetal Lung and Brain in Chorioamnionitis-Induced Preterm Birth Rat Model.
Authors: Yavuz A, Sezik M, Eris Yalcin S, Asci H, Ozmen O Abstract Objectives: Fingolimod (FIN) is used for multiple sclerosis treatment and has potential antiapoptotic and anti-inflammatory effects. We aimed at expanding our knowledge on various immunohistochemical markers for elucidating the possible mechanisms of action of fingolimod in the placenta and fetal lung and brain.Methods: Sixteen pregnant rats were divided into 4 groups. On gestational day 17, lipopolysaccharide (LPS) was injected intraperitoneally to induce preterm fetal injury followed by intraperitoneal injection of fingolimod. Hysterotomy for pret...
Source: Immunopharmacology and Immunotoxicology - September 9, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Future Perspective: Biologic agents in patients with Severe Covid-19.
Authors: Yalcin AD, Yalcin AN Abstract The SARS-CoV-2 is a β-CoV, which is enveloped by non-segmented positive- stranded RNA virüs. When β-CoV infects the respiratory tract, it can cause mild and/or severe acute respiratory syndrome with consequent release of cytokines/mediators, including interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8(CXCL8), IL-10, IP10, IL-12, IL-13, IL-17, IL-33, IL-25, IL-37, IL-38, GCSF, GM-CSF, HGF,IP-10, MCP-1, MIP-1α(also known as CCL3), IFN-γ, IFN-α, TRAIL, MCSF and TNF-α. Our hypothesis of writing this article can be summarized as; if ...
Source: Immunopharmacology and Immunotoxicology - September 6, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3 β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways.
CONCLUSION: the outcomes of the present study showed REB's ability to protect from hepatic injury induced by MTX, possibly through its antioxidant, anti-inflammatory, and anti-apoptotic properties. These effects could be attributed to REB's ability to modulate, at least in part, the Nrf2/GSK-3β,NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2signaling pathways. PMID: 32865051 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 2, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Interferon gamma/Interleukin-4 Modulation, Anti-inflammatory and Antioxidant Effects of Hesperidin in Complete Freund's Adjuvant (CFA)-Induced Arthritis Model of Rats.
This study sought to assess the effect of hesperidin on serum inflammatory cytokines and oxidative damage in liver of complete Freund's adjuvant (CFA)-induced arthritic rats.Method: Fifty-six adult female Wistar rats (220 - 250g) were acclimatized for two weeks. Intraplantar injection of CFA was done for the induction of arthritis and confirmed on the 14th day prior to oral administration of 40 and 80 mg/kg of hesperidin or dexamethasone for 45 days.Result: The result showed that treatment with both doses of hesperidin and dexamethasone in the joint of arthritic rats significantly (p 
Source: Immunopharmacology and Immunotoxicology - August 27, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF- α secretion from M1 macrophages.
CONCLUSION: Taken together, capsaicin alleviates liver fibrosis by inactivation of Notch signaling and further inhibiting TNF-α secretion from M1 macrophage. Targeting TNF-α or Notch signaling in macrophage represents a promising strategy to combat liver fibrosis. PMID: 32811220 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 21, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Kupffer cell inactivation ameliorates immune liver injury via TNF- α/TNFR1 signal pathway in trichloroethylene sensitized mice.
Kupffer cell inactivation ameliorates immune liver injury via TNF-α/TNFR1 signal pathway in trichloroethylene sensitized mice. Immunopharmacol Immunotoxicol. 2020 Aug 18;:1-27 Authors: Zhang JX, Xu QY, Yang Y, Li N, Zhang Y, Deng LH, Zhu QX, Shen T Abstract In our previous studies, we found that Kupffer cell activation and tumor necrosis factor (TNF)-α was increased in liver which took an important role in immune liver injury in Trichloroethylene (TCE) sensitized mice. However, the exact effect of them was not revealed yet. Thus, we select a Kupffer cell activity inhibitory drug, gadolinium...
Source: Immunopharmacology and Immunotoxicology - August 21, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Steviol, the active principle of the Stevia sweetener, causes a reduction of the cells of the immunological system even consumed in low concentrations.
Authors: Pasqualli T, Eduardha Espindola Chaves P, da Veiga Pereira L, Adílio Serpa É, Souza de Oliveira LF, Mansur Machado M Abstract Steviol is a natural diterpenoid glycoside isolated from Stevia rebaudiana Bertoni leaves and widely used as a non-caloric sweetener. In addition to their sweet taste, Steviol glycosides may also have some therapeutic benefits. There are few reports on the cytotoxicity of Steviol in human cells. Our objective was to test this sweetener under and at average concentrations of consumption, evaluating parameters of cytotoxicity, genotoxicity, and immunotoxicity. For this p...
Source: Immunopharmacology and Immunotoxicology - August 21, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Amphiregulin Alleviated Concanavalin A-induced Acute Liver Injury via IL-22.
Conclusion Areg showed direct protective effects against ConA-induced acute liver injury, which suggests the potential therapeutic application of Areg in immune-mediated ALF. PMID: 32806961 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 20, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Immunotoxinological effects triggered by the rattlesnake Crotalus durissus cumanensis, mapanare (Bothrops colombiensis) venoms and its purified fractions on spleen and lymph nodes cells.
Authors: Pulido-Méndez MM, Azuaje E, Rodríguez-Acosta A Abstract The snakes in Venezuela vary in their different venom composition amid the species. In this sense, studies have been carried out elucidating mechanisms related to their immunostimulatory and/or immunosuppressive effects in vitro,measuring inhibition or stimulation on the mice spleen and lymph nodes lymphocytes under the rattlesnake (Crotalus durissus cumanensis)(Cdc) and mapanare (Bothrops colombiensis) crude venoms actions, and also its purified fraction crotoxin (CTX) (Cdc) and a semi-purified fraction (SPF) (Bc) activities. The stimul...
Source: Immunopharmacology and Immunotoxicology - August 20, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Contribution of inflammasome complex in inflammatory-related eye disorders and its implications for anti-inflammasome therapy.
Authors: Rasoulinejad SA, Karkhah A, Paniri A, Saleki K, Pirzadeh M, Nouri HR Abstract Inflammasome complex is regarded as a major molecular regulator that exerts a significant function in caspase-1 activation and consequently, the development of cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). The secretion of these cytokines may induce inflammation. The role of inflammasomes in the pathologic process of eye-related illnesses like glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy has been well-studied over the past decade. However, the detailed pathogenic mechani...
Source: Immunopharmacology and Immunotoxicology - August 15, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Risperidone attenuates acetic acid-induced colitis in rats through inhibition of TLR4/NF-kB signaling pathway.
Authors: Yousefi-Manesh H, Dejban P, Mumtaz F, Abdollahi A, Chamanara M, Dehpour A, Hasanvand A, Rashidian A Abstract Aim The purpose of the present study is to explore the anti-inflammatory potential of risperidone in acetic acid-induced rat colitis through inhibition of TLR4/NF-kB pathwayMethods Acute colitis induction was done by intra-rectal administration of 2 mL of 4% diluted acetic acid solution. Two h after colitis induction, dexamethasone (2 mg/kg) as standard drugorrisperidone (2, 4 and 6 mg/kg) were administered orally to wistar rats for five consecutive days. 24 h after the l...
Source: Immunopharmacology and Immunotoxicology - August 14, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Magnesium isoglycyrrhizinate ameliorates Concanavalin A-induced liver injury via the p38 and JNK MAPK pathway.
Conclusion: These findings demonstrated that MgIG protects against ConA-induced immunological liver injury by markedly alleviating liver inflammation, and this provides guidance for the clinical amelioration of liver inflammation induced by immunological factors. PMID: 32787473 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 14, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Bromosulfophthalein Suppresses Inflammatory Effects in Lipopolysaccharide-Stimulated RAW264.7 Macrophages.
Conclusions: Taken together, these data suggest that BSP can attenuate inflammation through multiple signaling pathways. These findings highlightthe potential of BSP as a new anti-inflammatory agent. PMID: 32787484 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 14, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Atractylenolide III attenuates Bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2/NQO1/HO-1 pathway activation.
This study aimedto investigate whether AtrIII alleviated BLM-induced PF and oxidative stress in rats through the nuclear factor erythroid-2-related factor 2/NQO1,NAD(P)H:quinineoxidoreductase 1/Heme oxygenase-1 (Nrf2/NQO1/HO-1) pathway.Medium and high doseAtrIII(1.2, 2.4mg/kg)improved the lung injury and lung function in the BLM-induced Sprague-Dawley(SD) rats. AtrIII reduced the apoptosis rate and down-regulated the expression of Caspase-3 and Caspase-9.AtrIII(1.2, 2.4mg/kg)alleviated pulmonary fibrosis damageand down-regulated transforming growth factor-β (TGF-β) and α-smooth muscle actin(α-SMA)expr...
Source: Immunopharmacology and Immunotoxicology - August 13, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Anti-inflammatory effects of troxerutin are mediated through elastase inhibition.
Conclusion: The antioxidant and anti-inflammatory activities of TX in AT could be of relevance in the management of obesity. PMID: 32762381 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 13, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

HP-NAP ameliorates OXA-induced atopic dermatitis symptoms in mice.
Conclusions & clinical relevance: Taken together, our results showed that HP-NAP possessed the potential to be a novel immunomodulatory candidate drug against AD. PMID: 32762390 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 13, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Toll-like receptor (TLR) gene expression and immunostimulatory effect of CpG Oligonucleotides in hormone receptor positive cell line T47D and Triple negative breast cancer cell line MDA-MB-468.
Conclusion: Our in vitro finding gives preliminary evidence that triggering TLR9 using CpG ODN decreases the cell proliferation and alters the pro-inflammatory cytokines in favour of inhibition of hormone receptor positive breast cancer cells T47D and triple negative breast cancer cells MDA-MB-468. PMID: 32686546 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 22, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The double-edged role of IL-22 in organ fibrosis.
Authors: Chen J, Lodi R, Zhang S, Su Z, Wu Y, Xia L Abstract Fibrosis is unregulated tissue repair in damaged or diseased organs, and the accumulation of excess extracellular matrix (ECM) impacts the structure and functions of organs,leading to death. Fibrosis is usually triggered by inflammation and tissue damage, and inflammatory mediators stimulate the proliferation of myofibroblasts and the excessive production of ECM. The IL-10 family cytokines play important roles in the development of fibrosis, and its member IL-22has recentlyattracted specific attention.IL-22 plays great roles in preventing pathogens invasi...
Source: Immunopharmacology and Immunotoxicology - July 22, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Dual role of sirtuin 1 in inflammatory bowel disease.
Authors: Bansal K, Singh N, Jaggi AS Abstract Silent information regulator-1 (SIRT-1), is a member of the class III group of histone deacetylases and is collectively called sirtuins. There have been preclinical and clinical studies indicating the downregulation and decreased activity of sirtuin 1 in various inflammatory bowel disease models. Furthermore, the downregulation of sirtuin 1 is responsible for the sustained production of proinflammatory cytokines and the generation of oxidative stress in colitis. Hyperacetylation of NF-κB and HSF-1 (heat shock factor-1) in the absence of sirtuin1 is responsible for...
Source: Immunopharmacology and Immunotoxicology - July 5, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

A case of Asthma with Behcet's disease: successful treatment with Omalizumab and its effects on recurrent aphthous lesions.
Conclusions: Here, for the first time, we introduce omalizumab treatment of a patient diagnosed with BD and the examination of the treatment for the clinical manifestations and the cytokines/coagulant protein levels. A significant improvement is observed in the patient's RAL following the initiation of omalizumab. There is strong evidence that the serum proinflammatory cytokines/coagulant factors could also play an important role in the relationship between RAL and IgE-dependent vascular autoinflammation. PMID: 32605504 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 2, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression.
Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response. PMID: 32538204 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 18, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Carnosic acid inhibits inflammatory cytokines production in human periodontal ligament cells.
CONCLUSION: The results of this study suggest that CA has anti-inflammatory effects in human periodontal ligament cells by inhibiting JNK, NF-κB and STAT3 pathways. PMID: 32538208 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 18, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Dioscin exhibits anti-inflammatory effects in IL-1 β-stimulated human osteoarthritis chondrocytes by activating LXRα.
Conclusions: In conclusion, this study indicated that dioscin-mediated anti-inflammatory effect may be involved in the activation of LXRα. PMID: 32515238 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 11, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice.
Conclusions: Our data suggest that the BM-DC + HER2/neu + QS-21 + anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice. PMID: 32515626 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 11, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

15-hydroxy-6 α,12-epoxy-7β,10αH,11βH-spiroax-4-ene-12-onesensitizesrectal tumor cells to anti-PD1 treatment through agonism of CD11b.
Conclusions: Our results showed that HESEO improved anti-tumor T cell immunity and rendered anti-PD1 treatment effective in unresponsive tumor models, providing proof of concept for a new combination strategy involving molecular agonism of CD11b to bypass the limitations of current clinical strategies to overcome resistance to immunotherapies. PMID: 32508184 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 10, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Retraction: Laquinimod inhibits MMP-induced NLRP3 inflammasome activation in human neuronal cells.
Authors: PMID: 32500758 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 7, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Prophylactic effect of Biochanin A in lipopolysaccharide-stimulated BV2 microglial cells.
Conclusion:Taken together, these results show that Biochanin A exerts antioxidant and anti-inflammatory activities, thus may be beneficial for preventing neurodegenerative diseases mediated by microglial cells. PMID: 32482108 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 4, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research