Telitacicept as a BLyS/APRIL dual inhibitor for autoimmune disease
Immunopharmacol Immunotoxicol. 2021 Sep 14:1-8. doi: 10.1080/08923973.2021.1973493. Online ahead of print.ABSTRACTThe pathogenic roles for B cells in autoimmunity include produce pathogenic autoantibodies and modulate immune responses via the production of cytokines and chemokines. The B lymphocyte stimulator BLyS (also known as B-cell-activating factor, BAFF) and APRIL (a proliferation-inducing ligand) are critical factors in the maintenance of the B-cell pool and humoral immunity, namely BLyS modulates the differentiation and maturation of immature B cell, while APRIL modulates the function and survival of long-lived pla...
Source: Immunopharmacology and Immunotoxicology - September 14, 2021 Category: Allergy & Immunology Authors: Fan Shi Ran Xue Xuexiao Zhou Pei Shen Shengzhi Wang Yun Yang Source Type: research

sCD48 is elevated in non-allergic but not in allergic persistent rhinitis
CONCLUSIONS: CD48 may be involved in eosinophilic pathophysiological reactions in non-allergic rhinitis.PMID:34477021 | DOI:10.1080/08923973.2021.1973492 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Olga Branicka Edyta Jura-Szo łtys Barbara Rogala Joanna Gl ück Source Type: research

Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties
CONCLUSIONS: Up-regulation of hsa-circ_0003420 expression in LSCs caused redox disorder, inflammation and apoptosis, suggesting that this protein could be used as a target for the treatment AML.PMID:34477035 | DOI:10.1080/08923973.2021.1963272 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Guoqiang Lin Yingying Fei Yanming Zhang Source Type: research

sCD48 is elevated in non-allergic but not in allergic persistent rhinitis
CONCLUSIONS: CD48 may be involved in eosinophilic pathophysiological reactions in non-allergic rhinitis.PMID:34477021 | DOI:10.1080/08923973.2021.1973492 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Olga Branicka Edyta Jura-Szo łtys Barbara Rogala Joanna Gl ück Source Type: research

Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties
CONCLUSIONS: Up-regulation of hsa-circ_0003420 expression in LSCs caused redox disorder, inflammation and apoptosis, suggesting that this protein could be used as a target for the treatment AML.PMID:34477035 | DOI:10.1080/08923973.2021.1963272 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Guoqiang Lin Yingying Fei Yanming Zhang Source Type: research

sCD48 is elevated in non-allergic but not in allergic persistent rhinitis
CONCLUSIONS: CD48 may be involved in eosinophilic pathophysiological reactions in non-allergic rhinitis.PMID:34477021 | DOI:10.1080/08923973.2021.1973492 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Olga Branicka Edyta Jura-Szo łtys Barbara Rogala Joanna Gl ück Source Type: research

Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties
CONCLUSIONS: Up-regulation of hsa-circ_0003420 expression in LSCs caused redox disorder, inflammation and apoptosis, suggesting that this protein could be used as a target for the treatment AML.PMID:34477035 | DOI:10.1080/08923973.2021.1963272 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Guoqiang Lin Yingying Fei Yanming Zhang Source Type: research

sCD48 is elevated in non-allergic but not in allergic persistent rhinitis
CONCLUSIONS: CD48 may be involved in eosinophilic pathophysiological reactions in non-allergic rhinitis.PMID:34477021 | DOI:10.1080/08923973.2021.1973492 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Olga Branicka Edyta Jura-Szo łtys Barbara Rogala Joanna Gl ück Source Type: research

Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties
CONCLUSIONS: Up-regulation of hsa-circ_0003420 expression in LSCs caused redox disorder, inflammation and apoptosis, suggesting that this protein could be used as a target for the treatment AML.PMID:34477035 | DOI:10.1080/08923973.2021.1963272 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Guoqiang Lin Yingying Fei Yanming Zhang Source Type: research

sCD48 is elevated in non-allergic but not in allergic persistent rhinitis
CONCLUSIONS: CD48 may be involved in eosinophilic pathophysiological reactions in non-allergic rhinitis.PMID:34477021 | DOI:10.1080/08923973.2021.1973492 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Olga Branicka Edyta Jura-Szo łtys Barbara Rogala Joanna Gl ück Source Type: research

Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties
CONCLUSIONS: Up-regulation of hsa-circ_0003420 expression in LSCs caused redox disorder, inflammation and apoptosis, suggesting that this protein could be used as a target for the treatment AML.PMID:34477035 | DOI:10.1080/08923973.2021.1963272 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Guoqiang Lin Yingying Fei Yanming Zhang Source Type: research

sCD48 is elevated in non-allergic but not in allergic persistent rhinitis
CONCLUSIONS: CD48 may be involved in eosinophilic pathophysiological reactions in non-allergic rhinitis.PMID:34477021 | DOI:10.1080/08923973.2021.1973492 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Olga Branicka Edyta Jura-Szo łtys Barbara Rogala Joanna Gl ück Source Type: research

Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties
CONCLUSIONS: Up-regulation of hsa-circ_0003420 expression in LSCs caused redox disorder, inflammation and apoptosis, suggesting that this protein could be used as a target for the treatment AML.PMID:34477035 | DOI:10.1080/08923973.2021.1963272 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 3, 2021 Category: Allergy & Immunology Authors: Guoqiang Lin Yingying Fei Yanming Zhang Source Type: research

Correction
Immunopharmacol Immunotoxicol. 2021 Sep 1:1. doi: 10.1080/08923973.2021.1975024. Online ahead of print.NO ABSTRACTPMID:34468267 | DOI:10.1080/08923973.2021.1975024 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 1, 2021 Category: Allergy & Immunology Source Type: research

Zinc finger protein A20 regulates the development and progression of osteoarthritis by affecting the activity of NF- κB p65
CONCLUSION: A20 was reduced in OA cartilage samples, and its overexpression, by suppressing the activity of NF-κB p65, could improve IL-1β-induced chondrocyte degradation and apoptosis in vitro, as well as mitigate the inflammation in OA mice.PMID:34463587 | DOI:10.1080/08923973.2021.1970764 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 31, 2021 Category: Allergy & Immunology Authors: Shu-Bei Cui Tao-Xia Wang Zhen-Wu Liu Ji-Ying Yan Kai Zhang Source Type: research

Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway
Immunopharmacol Immunotoxicol. 2021 Aug 27:1-11. doi: 10.1080/08923973.2021.1966032. Online ahead of print.ABSTRACTOBJECTIVE: To determine the role of quercetin in non-small cell lung carcinoma (NSCLC) and the biological outcomes using transfection experiments.MATERIALS AND METHODS: Real-time reverse transcription-PCR and data collection were performed to determine lncRNA and miRNA levels. Transwell assay was performed to assess the invasion ability of cells. Apoptosis of cells digested with trypsin was determined using the Annexin V-FITC kit. Luciferase activity was determined using the luciferase reporter gene system. Ce...
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Ruonan Chai Chong Xu Liu Lu Xinwei Liu Zhuang Ma Source Type: research

Mechanism of neuroprotective effect of stevioside on cerebral ischemia-reperfusion injury via PPAR- γ activation
CONCLUSION: Stevioside alleviates MCAO/R-induced neuronal apoptosis and inflammation by upregulating PPAR-γ to activate PI3K/AKT signaling pathway.PMID:34448677 | DOI:10.1080/08923973.2021.1966034 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Yanli Zhang Source Type: research

Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway
Immunopharmacol Immunotoxicol. 2021 Aug 27:1-11. doi: 10.1080/08923973.2021.1966032. Online ahead of print.ABSTRACTOBJECTIVE: To determine the role of quercetin in non-small cell lung carcinoma (NSCLC) and the biological outcomes using transfection experiments.MATERIALS AND METHODS: Real-time reverse transcription-PCR and data collection were performed to determine lncRNA and miRNA levels. Transwell assay was performed to assess the invasion ability of cells. Apoptosis of cells digested with trypsin was determined using the Annexin V-FITC kit. Luciferase activity was determined using the luciferase reporter gene system. Ce...
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Ruonan Chai Chong Xu Liu Lu Xinwei Liu Zhuang Ma Source Type: research

Mechanism of neuroprotective effect of stevioside on cerebral ischemia-reperfusion injury via PPAR- γ activation
CONCLUSION: Stevioside alleviates MCAO/R-induced neuronal apoptosis and inflammation by upregulating PPAR-γ to activate PI3K/AKT signaling pathway.PMID:34448677 | DOI:10.1080/08923973.2021.1966034 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Yanli Zhang Source Type: research

Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway
Immunopharmacol Immunotoxicol. 2021 Aug 27:1-11. doi: 10.1080/08923973.2021.1966032. Online ahead of print.ABSTRACTOBJECTIVE: To determine the role of quercetin in non-small cell lung carcinoma (NSCLC) and the biological outcomes using transfection experiments.MATERIALS AND METHODS: Real-time reverse transcription-PCR and data collection were performed to determine lncRNA and miRNA levels. Transwell assay was performed to assess the invasion ability of cells. Apoptosis of cells digested with trypsin was determined using the Annexin V-FITC kit. Luciferase activity was determined using the luciferase reporter gene system. Ce...
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Ruonan Chai Chong Xu Liu Lu Xinwei Liu Zhuang Ma Source Type: research

Mechanism of neuroprotective effect of stevioside on cerebral ischemia-reperfusion injury via PPAR- γ activation
CONCLUSION: Stevioside alleviates MCAO/R-induced neuronal apoptosis and inflammation by upregulating PPAR-γ to activate PI3K/AKT signaling pathway.PMID:34448677 | DOI:10.1080/08923973.2021.1966034 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Yanli Zhang Source Type: research

Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7/miR-34a-5p pathway
Immunopharmacol Immunotoxicol. 2021 Aug 27:1-11. doi: 10.1080/08923973.2021.1966032. Online ahead of print.ABSTRACTOBJECTIVE: To determine the role of quercetin in non-small cell lung carcinoma (NSCLC) and the biological outcomes using transfection experiments.MATERIALS AND METHODS: Real-time reverse transcription-PCR and data collection were performed to determine lncRNA and miRNA levels. Transwell assay was performed to assess the invasion ability of cells. Apoptosis of cells digested with trypsin was determined using the Annexin V-FITC kit. Luciferase activity was determined using the luciferase reporter gene system. Ce...
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Ruonan Chai Chong Xu Liu Lu Xinwei Liu Zhuang Ma Source Type: research

Mechanism of neuroprotective effect of stevioside on cerebral ischemia-reperfusion injury via PPAR- γ activation
CONCLUSION: Stevioside alleviates MCAO/R-induced neuronal apoptosis and inflammation by upregulating PPAR-γ to activate PI3K/AKT signaling pathway.PMID:34448677 | DOI:10.1080/08923973.2021.1966034 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 27, 2021 Category: Allergy & Immunology Authors: Yanli Zhang Source Type: research

Silencing lncRNA LINC01410 suppresses cell viability yet promotes apoptosis and sensitivity to temozolomide in glioblastoma cells by inactivating PTEN/AKT pathway via targeting miR-370-3p
CONCLUSION: Silencing of LINC01410 inhibits cell viability yet enhances apoptosis and sensitivity to TMZ in GBM cells by inactivating PTEN/AKT pathway via targeting miR-370-3p.PMID:34435542 | DOI:10.1080/08923973.2021.1966031 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 26, 2021 Category: Allergy & Immunology Authors: Tingkai Fu Yunxue Yang Zhenxin Mu Rongwei Sun Xingang Li Jun Dong Source Type: research

Transplantation and immunosuppression: a review of novel transplant-related immunosuppressant drugs
Immunopharmacol Immunotoxicol. 2021 Aug 20:1-15. doi: 10.1080/08923973.2021.1966033. Online ahead of print.ABSTRACTImmunosuppressive drugs used in the transplantation period are generally defined as induction and maintenance therapy. The use of immunosuppressants, which are particularly useful and have fewer side effects, decreased both mortality and morbidity. Many drugs such as steroids, calcineurin inhibitors (cyclosporine-A, tacrolimus), antimetabolites (mycophenolate mofetil, azathioprine), and mTOR inhibitors (sirolimus, everolimus) are used as immunosuppressive agents. Although immunosuppressant drugs cause many sid...
Source: Immunopharmacology and Immunotoxicology - August 20, 2021 Category: Allergy & Immunology Authors: Hakan Parlakpinar Mehmet Gunata Source Type: research

Anti-inflammatory activities of a new VEGF blocker, Conbercept
CONCLUSION: All results indicate that Conbercept exhibits significant inhibition of acute and chronic inflammation.PMID:34402367 | DOI:10.1080/08923973.2021.1959608 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 17, 2021 Category: Allergy & Immunology Authors: Yang Liu Hua Fu Li Zuo Source Type: research

( < em > E < /em > )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone isolated from < em > Portulaca oleracea < /em > L. suppresses LPS-induced inflammation in RAW 264.7 macrophages by downregulating inflammatory factors
CONCLUSION: Overall, our results suggested that HM-chromanone suppresses LPS-induced inflammation in RAW 264.7 macrophages by downregulating the expression of inflammatory factors.PMID:34388059 | DOI:10.1080/08923973.2021.1963271 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 13, 2021 Category: Allergy & Immunology Authors: Eunji Kang Jae Eun Park Youngwan Seo Ji Sook Han Source Type: research

Impact of dietary exposure to low-dose tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice
DISCUSSION: These results suggested that dietary exposure to TDCIPP at TDI level slightly enhances allergic diseases, such as allergic asthma, via GPER regulation at inflamed sites and secondary lymphoid tissue and BM cell alternations.PMID:34388063 | DOI:10.1080/08923973.2021.1959609 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 13, 2021 Category: Allergy & Immunology Authors: Rie Yanagisawa Eiko Koike Tin-Tin Win-Shwe Maiko Kawaguchi Hirohisa Takano Source Type: research

( < em > E < /em > )-5-hydroxy-7-methoxy-3-(2'-hydroxybenzyl)-4-chromanone isolated from < em > Portulaca oleracea < /em > L. suppresses LPS-induced inflammation in RAW 264.7 macrophages by downregulating inflammatory factors
CONCLUSION: Overall, our results suggested that HM-chromanone suppresses LPS-induced inflammation in RAW 264.7 macrophages by downregulating the expression of inflammatory factors.PMID:34388059 | DOI:10.1080/08923973.2021.1963271 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 13, 2021 Category: Allergy & Immunology Authors: Eunji Kang Jae Eun Park Youngwan Seo Ji Sook Han Source Type: research

Impact of dietary exposure to low-dose tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice
DISCUSSION: These results suggested that dietary exposure to TDCIPP at TDI level slightly enhances allergic diseases, such as allergic asthma, via GPER regulation at inflamed sites and secondary lymphoid tissue and BM cell alternations.PMID:34388063 | DOI:10.1080/08923973.2021.1959609 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 13, 2021 Category: Allergy & Immunology Authors: Rie Yanagisawa Eiko Koike Tin-Tin Win-Shwe Maiko Kawaguchi Hirohisa Takano Source Type: research

Protective effect of sarsasapogenin in TNBS induced ulcerative colitis in rats associated with downregulation of pro-inflammatory mediators and oxidative stress
CONCLUSION: Thus, SG and SG + FC combination could alter the disease progression and could be a hopeful therapeutic target for the management of UC by reducing its dose in combination with FC to elude the long term adverse effects of FC.PMID:34338577 | DOI:10.1080/08923973.2021.1955919 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 2, 2021 Category: Allergy & Immunology Authors: Deepa S Mandlik Satish K Mandlik Snehal Patel Source Type: research

The effects of guluronic acid (G2013), a new emerging treatment, on inflammatory factors in nonalcoholic steatohepatitis patients under < em > in vitro < /em > conditions
CONCLUSION: The results indicated that G2013 could meaningfully decrease the expression and secretion levels of evaluated factors (TLR4, NF-κB, TNF-α, and IL-6) in PMBCs of NASH cases. Since there is no effective treatment for NASH patients, we hope that G2013 would be a promising immunomodulatory agent in reducing inflammation and improvement of patients.PMID:34314306 | DOI:10.1080/08923973.2021.1954946 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 27, 2021 Category: Allergy & Immunology Authors: Safa Tahmasebi Hassan Neishaboori Davood Jafari Elham Faghihzadeh Abdolreza Esmaeilzadeh Abbas Mirshafiey Source Type: research