Anti-inflammatory effect of synthesized indole-based chalcone (2E)-3-(4-bromophenyl)-1-(1H-indol-3-yl) prop-2-en-1-one: an in vitro and in vivo studies.
Conclusions: The targeting anti-inflammatory efficacy and profound NF-κB sensitive transcriptional regulatory mechanism of IC9 accounts for its effective anti-inflammatory action. PMID: 31594421 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - October 10, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Effects of guluronic acid (G2013) on gene expression of TLR2, TLR4, MyD88, TNF- α and CD52 in multiple sclerosis under in vitro conditions.
Conclusion: Data demonstrated that the guluronic acid is able to modify the expression levels of TLR2, TLR4 and TNF-α genes to less than the pathogenic boarder line level, which it might be recommended for reducing the pathological process in multiple sclerosis. PMID: 31594427 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - October 10, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Trace amine associated receptor 1 (TAAR1) expression and modulation of inflammatory cytokine production in mouse bone marrow-derived macrophages: a novel mechanism for inflammation in ulcerative colitis.
Conclusions: Our data suggest that TAAR1 is a mediator of macrophage inflammation and a potential therapeutic target to attenuate UC symptomology. PMID: 31570011 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - October 3, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Therapeutic effects of modafinil in ischemic stroke; possible role of NF- κB downregulation.
Conclusion: Our findings demonstrate a promising therapeutic effect of modafinil for animal models of stroke. PMID: 31542978 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 25, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Kaempferol alleviates LPS-ATP mediated inflammatory injury in splenic lymphocytes via regulation of the pyroptosis pathway in mice.
Conclusions: Our data suggest that kaempferol exhibits anti-pyroptosis activities, which warrants further detailed investigation. PMID: 31549524 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 25, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Resveratrol protects BV2 mouse microglial cells against LPS-induced inflammatory injury by altering the miR-146a-5p/TRAF6/NF- κB axis.
Conclusions: RSV can suppress LPS-induced inflammatory injury via modulating the miR-146a-5p/TRAF6/NF-κB axis in BV2 mouse microglial cells. PMID: 31530042 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 20, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inhibition of anti-viral responses in intestinal epithelial cells by epigenetic modifying drugs is mediated by a reduction in viral pattern recognition receptor expression and activity.
Conclusion: This research highlighted the potential immunoregulatory role of epigenetic modifying drugs specifically in response to viral stimulation. PMID: 31505962 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - September 13, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Mycophenolic acid enhanced lipopolysaccharide-induced interleukin-18 release in THP-1 cells via activation of the NLRP3 inflammasome.
Conclusions: Taken together, MPA synergized with LPS to induce the release of IL-18 via activating the NLRP3 inflammasome and increasing the degradation of pro-IL-18, rather than by enhancing the production of pro-IL-18. PMID: 31429348 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - August 22, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The multiple roles of exosomes in Parkinson's disease: an overview.
Authors: Porro C, Panaro MA, Lofrumento DD, Hasalla E, Trotta T Abstract The extracellular vesicles (EVs) represent a relatively new field of research in neurodegenerative disease and they are thought to be one of the ways that neurodegenerative pathologies, such as Parkinson's Disease (PD), spread in the brain. EVs are membrane vesicles released from cells into the extracellular space and they are produced by all cells of the nervous tissue. The classification of the vesicle subtypes comprises exosomes, microvesicles/microparticles, apoptotic bodies. EVs change in number and content in response to environmental co...
Source: Immunopharmacology and Immunotoxicology - August 15, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Fumaric acids as a novel antagonist of TLR-4 pathway mitigates arsenic-exposed inflammation in human monocyte-derived dendritic cells.
In this study, the in vitro therapeutic effects of FA on arsenic-exposed monocytes-derived dendritic cells (MDDCs) were evaluated. All the canonical functions of dendritic cells in bridging innate and adaptive immune system including phagocytosis and antigen-presenting capacity, and also cytokines secretion, were evaluated after exposure to arsenic/FA. FA profoundly over-expressed antigen-presenting capacity of MDDCs after exposure to arsenic through the upregulation of MHCιι. However, phagocytosis capacity of arsenic-exposed MDDCs is not compensated for, by treatment with FA. Arsenic up-regulates pro-inflammator...
Source: Immunopharmacology and Immunotoxicology - August 11, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Marine peptides as immunomodulators: Californiconus californicus-derived synthetic conotoxins induce IL-10 production by regulatory T cells (CD4+Foxp3+).
Conclusion: These results suggest that synthetic conotoxins exert immunomodulatory activity, especially by regulating specific functions on T lymphocytes. PMID: 31339393 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 26, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Isorhamnetin ameliorates inflammatory responses and articular cartilage damage in the rats of monosodium iodoacetate-induced osteoarthritis.
Discussion and conclusions: Isorhamnetin may modulate the inflammatory progression of OA in MIA-induced OA rats. The prevention of cartilage damage was found in OA after adequate isorhamnetin treatment. Isorhamnetin may serve as a potential agent for the management of OA. PMID: 31342791 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 26, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

T cells expressing CD26-specific chimeric antigen receptors exhibit extensive self-antigen-driven fratricide.
Conclusion: Eradicating CML-LSCs via anti-CD26-4-1BB-CAR T cells is not applicable, and optimized design or alternative target is needed. PMID: 31303072 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 16, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Astragaloside inhibits IL-1 β-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.
Conclusion: Astragaloside potentially serve as a promising and effective therapeutic agent for treating OA patients. PMID: 31293216 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 13, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inhibitory effect of rapamycin on proliferation of human umbilical arterial smooth muscle cells.
Discussion and conclusions: Rapamycin inhibits proliferation of HUASMCs in vitro and through down-regulation of IL-6 expression. PMID: 31232124 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 26, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Sulglycotide ameliorates inflammation in lipopolysaccharide-stimulated mouse macrophage cells by blocking the NF- κB signaling pathway.
Conclusions: These results indicate that sulglycotide could be an anti-inflammatory and anti-oxidative compound that may be a useful candidate for treatment of inflammatory diseases. PMID: 31232125 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 26, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inhibition of fatty acid metabolism by etomoxir or TOFA suppresses murine dendritic cell activation without affecting viability.
Conclusions: Both cDCs, the primary antigen presenting cell, and pDCs, the primary type I IFN producer, exhibit a suppressed ability to activate but normal viability when their FA metabolism is inhibited by etomoxir or TOFA. Our findings indicate that FA metabolism plays an important role in the activation of both pDCs and cDCs and suggest that its modulation is an exploitable therapeutic target to suppress DC activation in inflammation or autoimmunity. PMID: 31155984 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 5, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Leukemia inhibitory factor (LIF) modulates the development of dendritic cells in a dual manner.
Conclusions: Our results can reflect a role for LIF in the generation and particularly maturation of DCs. It can be assumed that LIF rather modulates the maturation level, leading to the development of semi-mature and tolerogenic DCs. According to the high levels of LIF in immune-privileged sites like brain and uterine, it seems that the cytokine may account for the formation of local DCs that help the establishment of immunosuppressive environments. PMID: 31142168 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 31, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells.
Conclusions: Our findings suggest that the combination of APAP and SFN enhanced anti-inflammatory and anti-oxidant activities in stimulated macrophages, which provide an important rationale to utilize drug and food in combination for prevention and/or treatment inflammation-related diseases. PMID: 31142171 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 31, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Correction.
Authors: PMID: 31134833 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 30, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Pulegone inhibits inflammation via suppression of NLRP3 inflammasome and reducing cytokine production in mice.
Conclusion: Pulegone exerts anti-inflammatory effects on LPS-induced sepsis mice via inhibition of the NLRP3 expression. PMID: 31134844 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 30, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inhibitory effect of recombinant human CXCL8(3-72)K11R/G31P on atherosclerotic plaques in a mouse model of atherosclerosis.
Conclusions: These findings indicate the potential therapeutic effects of G31P in suppressing the development of atherosclerosis by antagonizing the IL-8 receptor. G31P inhibits the proliferation and migration of VSMCs through regulating the Rho-kinase, ERK, and calcium-dependent pathways. PMID: 31124391 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 29, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Paeonol alleviates CCl4-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF- β/Smad3 signaling.
Conclusion: These data demonstrated that paeonol could alleviate CCl4-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF-β/Smad3 signaling. PMID: 31119954 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 24, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition.
CONCLUSION: These findings indicate that Madecassoside has potential to ameliorate inflammation in both acute gouty arthritis model and peritonitis model, probably via regulating IL-1β and NLRP3 expression. Practical point: Madecassoside also exhibited a urate-lowering effect and a renal protective effect in hyperuricemic mice. PMID: 31084401 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 17, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

An emerging role of interleukin-23 in rheumatoid arthritis.
Authors: Yuan N, Yu G, Liu D, Wang X, Zhao L Abstract Rheumatoid arthritis (RA) is an autoimmune, chronic inflammatory disease and is characterized by destruction of the articular cartilage. A number of pro-inflammatory cytokines work sequentially and in concert with one another to induce the development of RA. IL-23, a member of IL-12 family, is composed of p19 and p40 subunits and it interacts with IL-23 receptor complex to trigger plethora of biochemical actions. A number of preclinical studies have shown the role of IL-23 in the development of RA in rodents. IL-23 receptor signaling is primarily linked to the a...
Source: Immunopharmacology and Immunotoxicology - May 12, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Alpha-momorcharin regulates cytokine expression and induces apoptosis in monocytes.
CONCLUSIONS: The action of α-MMC on immune cells mainly affects monocytes, thereby eliciting its immunosuppressive effect. Its mode of action is to guide functional immunosuppressive regulation at low doses and induce apoptosis at high doses. As the monocytes would be recruited into tumor tissues and are polarized into tumor-associated macrophages, the selective cytotoxicity and cytokine release regulation of α-MMC in monocytes may be an important mechanism of its antitumor effects. PMID: 31062632 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 9, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Role of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in airway reactivity and inflammation in an allergic mouse model of asthma.
In this study, we investigated effects of AT1 receptor antagonist losartan, novel AT2 receptor agonist novokinin and AT2 receptor antagonist PD 123319 in a mouse model of asthma. METHODS: Mice were divided into control (CON) and allergen sensitized (SEN) groups. SEN was sensitized with ovalbumin (OVA) on days 1 and 6 (30 μg; i.p.), followed by 5% OVA aerosol challenge (days 11-13). Treatments included (a) losartan (SEN + LOS; 20 mg/kg i.p., day 14), (b) novokinin (SEN + NOV; 0.3 mg/kg i.p., day 14), and (c) PD 123319 (SEN + PD; 5 mg/kg i.p., day 1...
Source: Immunopharmacology and Immunotoxicology - May 9, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Modulating effect of a new ester, 28-O-phosphatidylbetulin (DAPB), obtained from hen egg yolk lecithin and betulin on lymphocyte subsets and humoral immune response in mice.
CONCLUSION: Despite the lack of cytotoxic activity, DAPB shows valuable immunomodulatory properties. PMID: 31056969 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 7, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Anti-inflammatory effect of 3,7-dimethyl-1,8-hydroxy-6-methoxyisochroman via nuclear factor erythroid 2-like 2-mediated heme oxygenase-1 expression in lipopolysaccharide-stimulated RAW264.7 and BV2 cells.
CONCLUSIONS: Collectively, the results of this study suggest that DMHM inhibited several inflammatory pathways including the NF-κB and MAPK pathways, and induced Nrf2-mediated HO-1 expression, demonstrating its potential usefulness for treating inflammatory and neuroinflammatory diseases. PMID: 31056974 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 7, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Osthole alleviates inflammation by down-regulating NF- κB signaling pathway in traumatic brain injury.
In conclusion, our findings demonstrated that osthole attenuated inflammatory response by inhibiting the NF-κB pathway in TBI. PMID: 31056982 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 7, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inhibition of interferon- γ production and T-bet expression by menthol treatment of human peripheral blood mononuclear cells.
Inhibition of interferon-γ production and T-bet expression by menthol treatment of human peripheral blood mononuclear cells. Immunopharmacol Immunotoxicol. 2019 May 06;:1-10 Authors: Bayat M, Kalantar K, Amirghofran Z Abstract CONTEXT: Mentha longifolia (L.) Huds., has shown anti-inflammatory effects. OBJECTIVE: To evaluate the immunomodulatory effects of menthol, the major constituent of Mentha longifolia on T cells as the main cells affecting the inflammatory responses. METHODS: Effect of menthol on: proliferation and viability of the peripheral blood human mononuclear cells (PBMCs) by ...
Source: Immunopharmacology and Immunotoxicology - May 7, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

A comparative evaluation of the immunotoxicity and immunomodulatory effects on macrophages exposed to aromatic trihalogenated DBPs.
CONCLUSIONS: TIP displayed higher cytotoxicity against macrophages than TBP and TCP, its brominated and chlorinated analogs. Since M1 and M2 macrophages facilitate the inflammatory and anti-inflammatory responses, respectively, the discrepancy of TCP, TBP, and TIP in inducing macrophage polarization may lead to distinct immunomodulatory and toxicological outcomes, thus giving rise to different types of diseases. This finding may provide novel insights into evaluating the toxicity of environmental pollutants on the immune system. PMID: 31046488 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 4, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Immunotherapeutic potential of an N-formylated peptide of Listeria monocytogenes in experimental tuberculosis.
Authors: Mir SA, Sharma S Abstract OBJECTIVE: The current therapeutic regimens for tuberculosis (TB) are complex and involve the prolonged use of multiple antibiotics with diverse side effects that lead to therapeutic failure and bacterial resistance. The standard appliance of immunotherapy may aid as a powerful tool to combat the ensuing threat of TB. We have earlier reported the immunotherapeutic potential of N-formylated peptides of two secretory proteins of Mycobacterium tuberculosis H37Rv. Here, we investigated the immunotherapeutic effect of an N-formylated peptide from Listeria monocytogenes in experimental ...
Source: Immunopharmacology and Immunotoxicology - May 4, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inflammatory mediators in exhaled breath condensate and peripheral blood of healthy donors and stable COPD patients.
Authors: Hao W, Li M, Zhang C, Zhang Y, Wang P Abstract OBJECTIVE: The aim of this work was to compare matrix metalloproteinase-9 and -12, tissue inhibitor of metalloproteinase-1 and -4, and neutrophil elastase in exhaled breath condensate (EBC) and peripheral blood of patients with COPD. METHODS: Peripheral blood and EBC samples from COPD patients and healthy donors were collected. In serum and EBC, MMP-9, MMP-12, NE, TIMP-1, and TIMP-4 proteins were detected by ELISA. The mRNA expression levels of MMP-9, MMP-12, NE, TIMP-1, and TIMP-4 in peripheral blood mononuclear cells (PBMCs) were analyzed by qRT-PCR. ...
Source: Immunopharmacology and Immunotoxicology - May 4, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Anti-inflammatory potential of hecogenin on atopic dermatitis and airway hyper-responsiveness by regulation of pro-inflammatory cytokines.
CONCLUSION: These data indicate that Hecogenin has been proved as a potential therapy for allergic skin diseases and bronchial asthma treatments in combination with Fluticasone by reducing its dose from 50 to 25 μg/mice in combination to circumvent the long term side effects of Fluticasone. The beneficial effect of Hecogenin may be related to the diminution of TNF-α and IL-12 cytokines production in Balb/c mice. PMID: 31039648 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 3, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Implications of immunotherapy with high-dose glatiramer acetate in acute phase of spinal cord injury in rats.
CONCLUSION: Along with confirmation of deleterious aspects of autoimmunity resulting from autoreactive lymphocytes against myelin antigens in SCI, this study has shown that high-dose immunotherapy using GA, especially in acute phase after SCI, overwhelms any neuroprotective effect of adoptive immune system. PMID: 31038378 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 2, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Meta-analysis on pharmacological therapies in the management of xerostomia in patients with Sjogren's syndrome.
Authors: Garlapati K, Kammari A, Badam RK, B E S, Boringi M, Soni P Abstract INTRODUCTION: Sjogren's syndrome is an immunologic disorder, characterized by symptoms of dry mouth and dry eyes. Management of xerostomia is more difficult and challenging, various pharmacologic agents have been tried and evaluated in the management of xerostomia in these patients, but the results were inconsistent and variable. Hence, the present study is aimed at evaluation and comparison of different pharmacological agents in the management of xerostomia in patients with Sjogren's syndrome. MATERIALS AND METHODS: A meta-analysis of...
Source: Immunopharmacology and Immunotoxicology - April 3, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Effects of sitagliptin and vitamin D3 on T helper cell transcription factors and cytokine production in clinical subgroups of type 2 diabetes mellitus: highlights upregulation of FOXP3 and IL-37.
CONCLUSION: These data demonstrate that sitagliptin in combination with VitD3 may accelerate the process of T2DM treatment by exerting synergic anti-inflammatory effects on immune system through upregulation of FOXP3 and IL-37, and downregulation of RORγt and BCL6 as well as IFN-γ, IL-17 and IL-21 production. Combined sitagliptin and VitD3 can be safely utilized to modulate the inflammatory conditions of T2DM. PMID: 30907193 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 27, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via α7nAChR to inhibit inflammation in LPS-stimulated macrophages.
CONCLUSIONS: SIN can decrease the expression of CD14/TLR4 and intracellular free calcium level, activate JAK2/STAT3 pathway to inhibit inflammatory response through α7nAChR in macrophages. PMID: 30896303 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 23, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Morphine consumption is associated with systemic inflammation in children undergoing allogeneic hematopoietic stem cell transplantation.
Authors: De Pietri S, Nielsen BN, Ifversen M, Kielsen K, Müller KG Abstract BACKGROUND: The majority of children undergoing allogenic hematopoietic stem cell transplantation (HSCT) experience severe pain due to chemotherapy-induced gastrointestinal toxicity. Inter-individual differences in pain perceived and opioid consumption remain unexplained, limiting the possibility for individualized pain control. The aim of this study was to investigate the associations between opioid consumption and markers of gastrointestinal toxicity (plasma citrulline) and systemic inflammation (plasma CRP and IL-6) in these patient...
Source: Immunopharmacology and Immunotoxicology - March 21, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

From the editors.
Authors: Pedersen AE PMID: 30880539 [PubMed - in process] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 20, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Effect of omega-3 fatty acid supplementation on resolvin (RvE1)-mediated suppression of inflammation in a mouse model of asthma.
Authors: Siddiquee A, Patel M, Rajalingam S, Narke D, Kurade M, Ponnoth DS Abstract OBJECTIVE: ResolvinE1 (RvE1), an endogenous lipid mediator derived from omega 3 fatty acids contributes to resolution of allergic inflammatory responses. We investigated effects of RvE1 (R) and omega 3 fatty acids (O) on airway reactivity and inflammation using allergic mice. METHODS: Mice were divided into control (nonasthmatic; CON) and allergen sensitized-challenged (asthmatic; SEN) groups, and were sensitized i.p. on days 1, 6 with 0.2 μg ovalbumin (OVA) followed by 5% OVA aerosol challenges on days 11-13. RvE1 was...
Source: Immunopharmacology and Immunotoxicology - March 10, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Agmatine ameliorates acetic acid-induced colitis in rats: involvement of nitrergic system.
Authors: Rashidian A, Keshavarz-Bahaghighat H, Abdollahi A, Chamanara M, Faghir-Ghanesefat H, Hoseini-Ahmadabadi M, Dehpour AR Abstract AIM: The aim of the present study is to investigate the anti-inflammatory effect of agmatine through the inhibition of iNOS enzyme in acetic acid-induced rat colitis. METHODS: Acute colitis was induced by administration of 2 mL of diluted acetic acid (4%) solution rectally. Two hours after colitis induction, animals were treated with normal saline, dexamethasone (2 mg/kg), agmatine (2, 5, 10 mg/kg), L-NAME (30 mg/kg), Aminoguanidine (20 mg/kg)...
Source: Immunopharmacology and Immunotoxicology - March 4, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Inhibition of tumor necrosis factor alpha and increased of interleukin 10 by Lactobacillus: a molecular mechanism protection against TNBS-induced ulcerative colitis in chicks.
In conclusion, Lactobacillus could ameliorate the effects on chicks of TNBS-induced ulcerative colitis by reducing the inflammation and regulating the expression of TNF-α and IL-10, respectively. PMID: 30821556 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 4, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Tachykinin upregulation in atopic dermatitis.
CONCLUSION: These findings indicate an upregulation of the tachykinergic system in the inflamed skin of AD. PMID: 30773959 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 20, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Protective effect of a topical sunscreen formulation fortified with melatonin against UV-induced photodermatitis: an immunomodulatory effect via NF- κB suppression.
CONCLUSION: It can be stated that melatonin included in the newly formulated sunscreen was able to inhibit the induction of photodermatitis via immunoregulation of inflammatory cytokines along with NF-κB and COX-2 genes. PMID: 30741582 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 12, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF- κB inhibition.
CONCLUSION: This study indicated that the action of DHMEQ's anti-AD like lesions might be related to its inhibition on NF-κB. PMID: 30724631 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 8, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Silica nanoparticles as an enhancer in the IL-1 β-induced inflammation cycle of A549 cells.
CONCLUSION: These results indicated that nano-SiO2 had a toxic effect on A549 cells, and this effect could increase IL-1β on the A549 cell-induced inflammatory response. The results suggested that the release of IL-1β and IL-6 in A549 was enhanced by the synergistic IL-1β-induced phosphorylation of ERK1/2 and I-κB. This process is similar to a snowball, and it is possible that IL-1β is continuously produced and repeatedly superimposed in A549 cells to produce an inflammatory effect; then, a vicious circle occurs, and an inflammatory storm is accelerated. PMID: 30724633 [PubMed - as supplied by...
Source: Immunopharmacology and Immunotoxicology - February 8, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The antagonistic effect of tamoxifen against d-galactosamine/lipopolysaccharide-induced acute liver failure is associated with reactivation of hepatic nuclear factor- κB.
CONCLUSIONS: Taking the results together with those of other studies, we conclude that TAM may attenuate Gal/LPS-induced ALF by antagonizing oxidative stress through NF-κB reactivation. PMID: 30721100 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 7, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Fluconazole induces genotoxicity in cultured human peripheral blood mononuclear cells via immunomodulation of TNF- α, IL-6, and IL-10: new challenges for safe therapeutic regimens.
CONCLUSIONS: Together, these findings suggest the need to rationalize the use of FNZ, especially if it is used for long periods or with concomitant pathologies requiring azole therapy that may increase FNZ's plasma concentration. PMID: 30721634 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 7, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research