Immunopharmacology and Immunotoxicology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Systematic Review of the Efficacy and Safety of Lenvatinib in Various Solid Tumors
Conclusions Lenvatinib in various solid tumors can prolong OS and disease PFS of patients, improve the clinical benefit rate and improve the quality of life of patients. At the same time, there is a certain incidence of adverse events, and symptomatic intervention should be given in clinical medication.PMID:38627024 | DOI:10.1080/08923973.2024.2344153 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 16, 2024 Category: Allergy & Immunology Authors: Shuai Geng Tong Liu Nan Wang Xinyue Gao Xinyu Luo Ning Shi Shuai Jiang Source Type: research

CCL2 regulated by the CTBP1-AS2/miR-335-5p axis promotes hemangioma progression and angiogenesis
Conclusion: Our findings suggest that targeting the CTBP1-AS2/miR-335-5p/CCL2 axis may hold promise as a therapeutic strategy for HA.PMID:38622049 | DOI:10.1080/08923973.2024.2330651 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 15, 2024 Category: Allergy & Immunology Authors: Ruixuan Li Ying Liu Jianfeng Liu Bo Chen Zhongjie Ji Aixia Xu Tianhua Zhang Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction
Discussion: T-cells are identified as the primary initiators of immunological abnormalities in RA. These RA T-cells show a distinct metabolic pattern compared to the healthy individuals. Dampened glycolytic flux, poor ATP production, and shifting of glucose to the pentose phosphate pathway resulting in increased NADPH and decreased ROS levels are the common metabolic patterns observed in RA T-cells. Defective mtDNA due to lack of MRE11A gene, a key molecular actor for resection, and inefficient lysosomal function due to misplacement of AMPK on the lysosomal surface were found to be responsible for mitochondrial and lysosom...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Asmita Parab Lokesh Kumar Bhatt Source Type: research

Immuno-metabolic reprogramming of T cell: a new frontier for pharmacotherapy of Rheumatoid arthritis
Immunopharmacol Immunotoxicol. 2024 Mar 25:1-11. doi: 10.1080/08923973.2024.2330636. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognized as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other ...
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Sourav Mondal Sarthak Saha Debjeet Sur Source Type: research

Immunosuppressants against acute kidney injury: what to prefer or to avoid?
Conclusion: Understanding the effects of immunosuppressants on AKI is crucial for optimizing patient care. This review highlights the need for further research to determine the most suitable immunosuppressants for AKI patients, considering both their efficacy and potential side effects.PMID:38477877 | DOI:10.1080/08923973.2024.2330641 (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 13, 2024 Category: Allergy & Immunology Authors: Swati Mishra Vishwadeep Shelke Neha Dagar Maciej Lech Anil Bhanudas Gaikwad Source Type: research