Toll-like receptor (TLR) gene expression and immunostimulatory effect of CpG Oligonucleotides in hormone receptor positive cell line T47D and Triple negative breast cancer cell line MDA-MB-468.
Conclusion: Our in vitro finding gives preliminary evidence that triggering TLR9 using CpG ODN decreases the cell proliferation and alters the pro-inflammatory cytokines in favour of inhibition of hormone receptor positive breast cancer cells T47D and triple negative breast cancer cells MDA-MB-468. PMID: 32686546 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 22, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The double-edged role of IL-22 in organ fibrosis.
Authors: Chen J, Lodi R, Zhang S, Su Z, Wu Y, Xia L Abstract Fibrosis is unregulated tissue repair in damaged or diseased organs, and the accumulation of excess extracellular matrix (ECM) impacts the structure and functions of organs,leading to death. Fibrosis is usually triggered by inflammation and tissue damage, and inflammatory mediators stimulate the proliferation of myofibroblasts and the excessive production of ECM. The IL-10 family cytokines play important roles in the development of fibrosis, and its member IL-22has recentlyattracted specific attention.IL-22 plays great roles in preventing pathogens invasi...
Source: Immunopharmacology and Immunotoxicology - July 22, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Dual role of sirtuin 1 in inflammatory bowel disease.
Authors: Bansal K, Singh N, Jaggi AS Abstract Silent information regulator-1 (SIRT-1), is a member of the class III group of histone deacetylases and is collectively called sirtuins. There have been preclinical and clinical studies indicating the downregulation and decreased activity of sirtuin 1 in various inflammatory bowel disease models. Furthermore, the downregulation of sirtuin 1 is responsible for the sustained production of proinflammatory cytokines and the generation of oxidative stress in colitis. Hyperacetylation of NF-κB and HSF-1 (heat shock factor-1) in the absence of sirtuin1 is responsible for...
Source: Immunopharmacology and Immunotoxicology - July 5, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

A case of Asthma with Behcet's disease: successful treatment with Omalizumab and its effects on recurrent aphthous lesions.
Conclusions: Here, for the first time, we introduce omalizumab treatment of a patient diagnosed with BD and the examination of the treatment for the clinical manifestations and the cytokines/coagulant protein levels. A significant improvement is observed in the patient's RAL following the initiation of omalizumab. There is strong evidence that the serum proinflammatory cytokines/coagulant factors could also play an important role in the relationship between RAL and IgE-dependent vascular autoinflammation. PMID: 32605504 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - July 2, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression.
Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response. PMID: 32538204 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 18, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Carnosic acid inhibits inflammatory cytokines production in human periodontal ligament cells.
CONCLUSION: The results of this study suggest that CA has anti-inflammatory effects in human periodontal ligament cells by inhibiting JNK, NF-κB and STAT3 pathways. PMID: 32538208 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 18, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Dioscin exhibits anti-inflammatory effects in IL-1 β-stimulated human osteoarthritis chondrocytes by activating LXRα.
Conclusions: In conclusion, this study indicated that dioscin-mediated anti-inflammatory effect may be involved in the activation of LXRα. PMID: 32515238 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 11, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Investigation of the combination of anti-PD-L1 mAb with HER2/neu-loaded dendritic cells and QS-21 saponin adjuvant: effect against HER2 positive breast cancer in mice.
Conclusions: Our data suggest that the BM-DC + HER2/neu + QS-21 + anti-PD-L1 vaccine combination paradigm synergistically generates anti-tumor activity and immune responses against HER2 overexpressing breast cancer in mice. PMID: 32515626 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 11, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

15-hydroxy-6 α,12-epoxy-7β,10αH,11βH-spiroax-4-ene-12-onesensitizesrectal tumor cells to anti-PD1 treatment through agonism of CD11b.
Conclusions: Our results showed that HESEO improved anti-tumor T cell immunity and rendered anti-PD1 treatment effective in unresponsive tumor models, providing proof of concept for a new combination strategy involving molecular agonism of CD11b to bypass the limitations of current clinical strategies to overcome resistance to immunotherapies. PMID: 32508184 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 10, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Retraction: Laquinimod inhibits MMP-induced NLRP3 inflammasome activation in human neuronal cells.
Authors: PMID: 32500758 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 7, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Prophylactic effect of Biochanin A in lipopolysaccharide-stimulated BV2 microglial cells.
Conclusion:Taken together, these results show that Biochanin A exerts antioxidant and anti-inflammatory activities, thus may be beneficial for preventing neurodegenerative diseases mediated by microglial cells. PMID: 32482108 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - June 4, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Immunotherapy in patients with local HPV infection and high-grade squamous intraepithelial lesion following uterine cervical conization.
Authors: Kovachev SM Abstract Objective: To establish the clearance of cervical human papillomavirus (HPV) infection following postoperative immunotherapy with inosine pranobex in women receiving surgical treatment of established high-grade squamous intraepithelial lesion (HSIL) of the uterine cervix.Materials and methods: Over the six-year study period, 32 women with cervical HPV infection following electroconization (loop electrosurgical excision procedure) of the uterine cervix for established HSIL were randomly divided into two groups: I (n = 10) without and II (n = 22) with postoper...
Source: Immunopharmacology and Immunotoxicology - May 22, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF- κB via activation of SIRT1 in mice.
Conclusions: These results suggest that aloin exerts its protective effects on LPS-induced ALI by activation SIRT1, which subsequently results in the suppression of NF-κB and NLRP3 inflammasome. PMID: 32419528 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Phenotypic analysis of tumor-infiltrating lymphocytes from non-small cell lung cancer and their potential application for adoptive cell therapy.
In this study, we successfully expanded TILs from 141 NSCLC tissues which can be used in clinical ACT after expansion by a rapid expansion protocol (REP). Results: Our study indicates that the clinicopathological characteristics of patients have considerable impacts on the phenotype of in vitro TIL culture products. Different culture conditions are necessary for patients with different clinical features. Specific manipulations before REP expansion are required depending on the different phenotypes of TIL cultures (e.g. depletion of immune-suppressive γδT cells). With these optimizations, next-generation TI...
Source: Immunopharmacology and Immunotoxicology - May 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Involvement of heme oxygenase-1 in suppression of T cell activation by quercetin.
Conclusion: Our findings indicate that the quercetin may be a promising candidate for inducing HO-1 in T cells, thereby facilitating immunosuppressive effects. PMID: 32397768 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - May 15, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The expression of thioredoxin-1 and inflammatory cytokines in patients with sepsis.
Conclusion: Our results show that Trx-1 play important role in inflammation and oxidative stress in sepsis patients. Trx-1 may be a potential therapeutic target in sepsis. PMID: 32326777 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 26, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Protective effect of dapsone against renal ischemia-reperfusion injury in rat.
Conclusion: These results support the hypothesis that the positive effects of dapsone on the renal ischemia/reperfusion injury are mediated by modulating inflammatory cascades. PMID: 32321337 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 25, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Paeoniflorin suppresses IL-33 production by macrophages.
Conclusions: PF suppresses IL-33 production by macrophages via inhibiting NF-κB and P38MAPK activation associated with the regulation of Ca2+ mobilization. PMID: 32312124 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 23, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Expression of concern.
Authors: PMID: 32252572 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 9, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Involvement of P450s and nuclear receptors in the hepatoprotective effect of quercetin on liver injury by bacterial lipopolysaccharide.
Conclusions: Our findings suggested that Que pretreatment could ameliorate LPS-induced liver injury. PMID: 32253952 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 9, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Expression of Concern.
Authors: PMID: 32267184 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 9, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Cholinergic agonists inhibit proliferation of human fibroblast-like synoviocytes and monocytic cell lines and reduce VEGF and MMPs expression by these cells.
Conclusion and implications: Our results suggest that cholinergic agonists can modulate pathological conditions related to pannus formation in in-vitro conditions. Based on these results, cholinergic agonists can be considered as novel therapeutic options in RA. Further animal studies are needed before introducing these agents into clinical uses. PMID: 32248717 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 8, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Alteration of liver immunity by increasing inflammatory response during co-administration of methamphetamine and atazanavir.
Conclusion: These results demonstrated that METH and atazanavir had a combined impact on the liver immunity, suggesting that the co-treatment could enhance inflammatory response and suppress NK cell activation via CD48. PMID: 32249638 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 8, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Laquinimod inhibits MMP+  induced NLRP3 inflammasome activation in human neuronal cells.
Conclusion: These findings suggest that laquinimod treatment might be a possible therapeutic strategy for neuroinflammation in PD. PMID: 32249647 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 8, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats.
Conclusion: These results provided pieces of evidence that the hepatoprotective effect of melatonin and celecoxib is possibly mediated through the modulation of JNK and TNF-α signaling pathways with subsequent suppression of inflammatory and apoptotic processes. PMID: 32249710 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - April 8, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The role of β-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-κB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients.
In this study (Trial Registration Number: IRCT2017100213739N10), 12 RA patients (according to the American College of Rheumatology criteria) and 12 healthy subjects (as control group) were selected. The gene expression of miR-146a, IRAK1, TRAF6, and NF-κB were measured at the baseline and after 12 weeks M2000 therapy, using quantitative real-time PCR method. Moreover, the serum levels of IL-6 and TNF-α were evaluated at the similar times by ELISA method.Results: Our findings showed that the gene expression of miR-146a, IRAK1, TRAF6, and NF-κB significantly decreased after 12 weeks M2000 ther...
Source: Immunopharmacology and Immunotoxicology - April 2, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Mechanism of tumor cells escaping from immune surveillance of NK cells.
Authors: Ge Z, Wu S, Zhang Z, Ding S Abstract Natural killer (NK) cells play an important role in anti-tumor and anti-infection, and perform their immune surveillance function in various ways. However, no matter what kind of cancer, the functional activity of NK cells in the tumor microenvironment (TME) is suppressed. Understanding the relationship between tumor cells and NK cells is very critical for tumor immunotherapy. This review discusses the mechanism of tumor cells escaping the immune surveillance of NK cells. These include a variety of factors that inhibit the activity of NK cells, an imbalance of activatin...
Source: Immunopharmacology and Immunotoxicology - April 2, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis.
Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis. PMID: 32216502 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 30, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

A review of the effects of the anesthetic gas nitrous oxide on the immune system; a starting point for future experiences.
Authors: Mohsenzadegan M, Kourosh Arami M, Oshaghi M, Sedigh Maroufi S Abstract Nitrous oxide is a common gas used as an anesthetic agent and analgesic medication in operating rooms. The gas inhibits vitamin B12 dependent-methionine synthase, which converts L-homocysteine and 5-methyltetrahydrofolate to L-methionine and tetrahydrofolate, respectively, via a methylation process. The immune system has been frequently reported to be suppressed in anesthetized subjects during the postoperative period. Although previous reviews have focused on the pathophysiologic role of nitrous oxide, none of them has considered the h...
Source: Immunopharmacology and Immunotoxicology - March 7, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Allergen challenge-induced changes in bone-marrow responses to leukotriene D4, nonsteroidal anti-inflammatory drugs and cytokines.
Conclusion: Allergen challenge modifies eosinopoiesis through systemic (glucocorticoid- and CysLT1R-dependent) mechanisms, increasing responses to IL-5 but restricting responses to subsequent CysLT1R stimulation. PMID: 32122206 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 4, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Ferulic acid alleviates atopic dermatitis-like symptoms in mice via its potent anti-inflammatory effect.
Conclusion: Our findings demonstrated that FA could serve as a promising therapeutic agent in AD treatment. PMID: 32122212 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 4, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The potential hepatoprotective effects of lovastatin combined with oral hypoglycemic agents in streptozotocin-induced diabetes in rats.
Conclusions: Hepatic complications associated with diabetes could be improved by combination of metformin or gliclazide with lovastatin. PMID: 32114843 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 3, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Cyclosporine attenuates Paraquat-induced mitophagy and pulmonary fibrosis.
Conclusions: Therefore, CsA can inhibit the PQ-induced mitophagy and pulmonary fibrosis by attenuating the PINK1/Parkin signaling. PMID: 32116062 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 3, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Sinomenine alleviates lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages.
Conclusions: This study indicated that SIN alleviated LPS-induced inflammatory responses in RAW264.7 macrophages by downregulating miR-155 and upregulating SOCS1, at least partly, leading to the suppression of NF-ĸB transcription. These findings suggest that SIN might be developed as an alternative and promising drug for the treatment of inflammatory diseases. PMID: 32116077 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - March 3, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Cordycepin exhibits a suppressive effect on T cells through inhibiting TCR signaling cascade in CFA-induced inflammation mice model.
Conclusions: These findings suggest that cordycepin regulates TCR signaling to inhibit excessive T cell activation in inflammation. Thus, cordycepin may be a potential therapeutic application in inflammation-associated diseases. PMID: 32105161 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 29, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Ketoprofen hypersensibility and idiosyncratic response - a case report.
Discussion and conclusion: Maybe it was a case of drug-induced liver disease, however therapeutic dosages of all administered drugs only once. The mechanisms involved were not investigated, but may be the result of allergic and immunologic aspects caused by ketoprofen and facilitated by a history of hypersensitivity to other NSAIDs as reported by the patient. As for jaundice can be attributed to drug toxicity since laboratory parameters did not reveal any evidence of liver disease. PMID: 32079429 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 23, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Combination of Sarsasapogenin and Fluticasone attenuates ovalbumin-induced airway inflammation in a mouse asthma model.
Conclusion: Our study results suggested that SG and SG + FC effectively reduced allergic airway inflammation via inhibiting pro-inflammatory cytokines, NO expressions and oxidative stress parameters. So, it could be used as a therapeutic potential agent for the treatment of asthma by decreasing its dose in combination with FC to avoid the chronic adverse effects of FC. PMID: 32070162 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 21, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

New insights into the novel anti-inflammatory mode of action of glucocorticoids.
Authors: Ingawale DK, Mandlik SK Abstract Inflammation is a physiological intrinsic host response to injury meant for removal of noxious stimuli and maintenance of homeostasis. It is a defensive body mechanism that involves immune cells, blood vessels and molecular mediators of inflammation. Glucocorticoids (GCs) are steroidal hormones responsible for regulation of homeostatic and metabolic functions of body. Synthetic GCs are the most useful anti-inflammatory drugs used for the treatment of chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), allergies, multiple sclerosis, te...
Source: Immunopharmacology and Immunotoxicology - February 21, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Alantolactone mitigates renal injury induced by diabetes via inhibition of high glucose-mediated inflammatory response and macrophage infiltration.
Conclusions: These findings suggest that ALA may hold promise in the treatment of DN, and importantly, the anti-inflammatory system may prove to be a new strategy to treat human DN. PMID: 32064988 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Mast cell stabilizer modulates Sirt1/Nrf2/TNF pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of cyclophosphamide hepatotoxicity.
Conclusion: Mast cell stabilizer, ketotifen possesses potent ameliorative effects against the hepatotoxic effect of CYC by reducing oxidative stress, inflammatory process, and apoptosis through regulation of Sirt1/Nrf2/TNF pathway. PMID: 32066295 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The effects of CTX damage or inhibition of bone marrow hematopoiesis and GM-CSF stimulation of bone marrow hematopoiesis on the peripheral blood TCR β CDR3 repertoire of BALB/c mice.
Conclusions: These data reveal that CTX significantly reduced the number of WBCs and ratio of high-frequency TCR CDR3 sequences, and indirectly increased the diversity of the TCR CDR3 repertoire. GM-CSF quickly restored the number of WBCs, and partially restored changes in the TCR CDR3 repertoire induced by CTX. Results from monitoring the dynamic changes of the TCR CDR3 repertoire can be used to assess the effects of CTX and GM-CSF on the function of peripheral blood T cells and to explore the possible underlying mechanisms. PMID: 32066303 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 19, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells.
Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells. However, the efficacy of NOB was different in PCa cells due to the hormone status and aggressive features. PMID: 32048561 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 14, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Sulforaphane mitigates mast cell-mediated allergic inflammatory reactions in in silico simulation and in  vitro models.
Conclusion: Our findings suggest that sulforaphane and WE have anti-allergic inflammatory effects by intercepting caspase-1/NF-κB/MAPKs signaling pathways. PMID: 32041439 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - February 12, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Paradoxical reaction to rituximab in patients with pemphigus: a report of 10 cases.
Authors: Nili A, Tavakolpour S, Mahmoudi H, Noormohammadpour P, Balighi K, Daneshpazhooh M PMID: 31986931 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 30, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Differential expression of CRAC channel in alloxan induced Diabetic BALB/c mice.
Conclusions: This study suggests that differential expression of CRAC channel correlated with the expression of inflammatory cytokines, thus CRAC channel might be responsible for the increased production of inflammatory cytokines in the alloxan induced T1D mice. PMID: 31983259 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - January 29, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Immunomodulatory role of recombinant human erythropoietin in acute kidney injury induced by crush syndrome via inhibition of the TLR4/NF- κB signaling pathway in macrophages.
Immunomodulatory role of recombinant human erythropoietin in acute kidney injury induced by crush syndrome via inhibition of the TLR4/NF-κB signaling pathway in macrophages. Immunopharmacol Immunotoxicol. 2020 Jan 23;:1-11 Authors: Zhou J, Bai Y, Jiang Y, Tarun P, Feng Y, Huang R, Fu P Abstract Objective: The present study aimed to investigate whether recombinant human erythropoietin (rHuEPO) plays an immunomodulatory function by regulating the TLR4/NF-κB signaling pathway.Materials and methods: C57BL/6 mice were intraperitoneally injected with rHuEPO and, half an hour later, with 50% glyce...
Source: Immunopharmacology and Immunotoxicology - January 25, 2020 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

In vitro impact of bisphenol A on maturation and function of monocyte-derived dendritic cells in patients with primary Sj ögren's syndrome.
Conclusions: BPA altered the function of moDCs through ERα, including antigen capture, secretion of inflammatory factors, and ability to stimulate T cells, as well as accelerated the progression and further deterioration of pSS. PMID: 31876196 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 27, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Effects of guluronic acid, as a new NSAID with immunomodulatory properties on IL-17, ROR γt, IL-4 and GATA-3 gene expression in rheumatoid arthritis patients.
Conclusion: G2013 as a natural novel drug showed a significant increase on IL-4 and GATA-3 and a significant decrease on RORγt gene expression after 12 weeks oral administration of this drug in RA patients. (Clinical trial identifier: IRCT2016092813739N5). PMID: 31856612 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - December 21, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

The effects of cadmium exposure in the induction of inflammation.
Authors: Hossein-Khannazer N, Azizi G, Eslami S, Alhassan Mohammed H, Fayyaz F, Hosseinzadeh R, Usman AB, Kamali AN, Mohammadi H, Jadidi-Niaragh F, Dehghanifard E, Noorisepehr M Abstract Inflammation is a physiological process essential for maintaining homeostatic mechanisms in human, but however, exaggerated inflammatory responses are closely related to many chronic diseases. Cadmium (Cd) is a heavy metal with high toxicity when present in food, water and air has the potential of eliciting inflammatory reactions, with a major health risk to human. This review aimed to elucidate on the major routes of Cd exposure, ...
Source: Immunopharmacology and Immunotoxicology - December 4, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research

Apigenin exhibits anti-inflammatory effects in LPS-stimulated BV2 microglia through activating GSK3 β/Nrf2 signaling pathway.
Conclusions: Collectively, apigenin suppressed LPS-induced microglia activation via activating GSK3β/Nrf2 signaling pathway. PMID: 31760890 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
Source: Immunopharmacology and Immunotoxicology - November 27, 2019 Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research