Sensitivity and specificity of Interleukin 29 in patients with rheumatoid arthritis and other rheumatic diseases.
a Rocha Pitta MG Abstract BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic and progressive inflammation that can cause a high degree of disability in affected individuals. Proinflammatory cytokines play central roles in the development of degradative and inflammatory responses in RA. IL-29 has been identified in RA and reported as a biomarker of the disease. OBJECTIVE: To analyze serum levels and accuracy of IL-29 in RA patients compared to healthy subjects and patients with other rheumatic diseases. METHODS: IL-29 serum levels were measured in 121 patients ...
Source: Immunology Letters - January 16, 2020 Category: Allergy & Immunology Authors: da Rocha Junior LF, Angela Luzia Branco PD, de Melo Rêgo MJB, de Almeida AR, de Melo Vilar K, de Lima HD, Andréa Tavares D, de Ataíde Mariz H, da Rocha Pitta I, da Rocha Pitta MG Tags: Immunol Lett Source Type: research

Effects of yolkin on the immune response of mice and its plausible mechanism of action.
In conclusion, this is a first demonstration of immunotropic properties of yolkin in in vitro and in vivo tests. The results provide evidence for induction of maturation and stimulatory signals in immature T and B cells by the protein, suggesting its potential role in the development of an embryo's immune system. PMID: 31954800 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - January 16, 2020 Category: Allergy & Immunology Authors: Obmińska-Mrukowicz B, Szczypka M, Lis M, Pawlak A, Suszko-Pawłowska A, Sysak A, Zambrowicz A, Burster T, Kocięba M, Artym J, Zaczyńska E, Kochanowska I, Zimecki M Tags: Immunol Lett Source Type: research

Analysis of the frequency of type 2 innate lymphoid cells and regulatory T cells in abortion-prone mice.
Abstract Recurrent spontaneous abortion (RSA) is the most common pregnancy related complication, affecting 1-5% of pregnancies. Despite hormonal, genetic and anatomical factors that result in abortion, impairment of immune response at the feto-maternal interface during the first trimester of pregnancy is also one of the main causes of RSA. In the present study, we evaluated the frequency of blood and uterine group 2 innate lymphoid cells (ILC2s), their subsets and regulatory T cells (Tregs) in CBA/J × DBA/2 J as an abortion-prone model compared to normal pregnant (NP) mice using immunoph...
Source: Immunology Letters - January 13, 2020 Category: Allergy & Immunology Authors: Ali-Hassanzadeh M, Sadat Hosseini M, Ahmadi M, Zare M, Akbarzadeh-Jahromi M, Derakhshanfar A, Gharesi-Fard B Tags: Immunol Lett Source Type: research

Detection of tumor antigens and tumor-antigen specific T cells in NSCLC patients: correlation of the quality of T cell responses with NSCLC subtype.
ins I Abstract Allogeneic cancer cell lines serve as universal source of tumor-associated antigens in cancer vaccines. Immunogenic high hydrostatic pressure-killed cancer cells derived from cell lines can be used for the generation of dendritic cell (DC)-based active cellular immunotherapy of non-small cell lung cancer (NSCLC). We investigated the expression of 12 known NSCLC tumor-associated antigens (TAA) (CEA, MAGE-A1, MAGE-A3, MAGE-A4, PRAME, hTERT, HER2, MUC1, Survivin, STEAP1, SOX2 and NY-ESO-1) in 6 NSCLC cell lines as candidates for the generation of DC-based lung cancer vaccine. We showed that the selecte...
Source: Immunology Letters - January 10, 2020 Category: Allergy & Immunology Authors: Ondrej P, Hradilova Nada P, Mysiková D, Kutna B, Mrazkova H, Lischke R, Spisek R, Adkins I Tags: Immunol Lett Source Type: research

Immunoregulatory properties of mesenchymal stem cells: Micro-RNAs.
Abstract Mesenchymal stem cells (MSCs) are multipotent cells that are excellent candidates for different cellular therapies due to their physiological properties such as immunoregulatory function. whetheare currently utilized for regenerative medication and treatment of a number of inflammatory illnesses given their ability to considerably impact tissue microenvironments via extracellular vesicles or toll-like receptor pathway modulation. MicroRNAs (miRNAs) are small noncoding RNAs that target the messenger RNA and play a critical role in different biological procedures, such as the development and reaction of the...
Source: Immunology Letters - January 5, 2020 Category: Allergy & Immunology Authors: Rostami Z, Khorashadizadeh M, Naseri M Tags: Immunol Lett Source Type: research

Targeting ROCK signaling in health, malignant and non-malignant diseases.
Abstract A Rho-associated coiled-coil kinase (ROCK) is identified as a critical downstream effector of GTPase RhoA which contains two isoforms, ROCK1 (also known as p160ROCK and ROKβ) and ROCK2 (also known as Rho-kinase and ROKα), the gene of which is placed on chromosomes 18 (18q11.1) and 2 (2p24), respectively. ROCKs have a principal function in the generation of actin-myosin contractility and regulation of actin cytoskeleton dynamics. They represent a chief role in regulating various cellular functions, such as apoptosis, growth, migration, and metabolism through modulation of cytoskeletal actin synt...
Source: Immunology Letters - January 2, 2020 Category: Allergy & Immunology Authors: Shahbazi R, Baradaran B, Khordadmehr M, Safaei S, Baghbanzadeh A, Jigari F, Ezzati H Tags: Immunol Lett Source Type: research

Outer membrane vesicle increases the efficacy of an influenza vaccine in a diet-induced obese mouse model.
PMID: 31901375 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - December 31, 2019 Category: Allergy & Immunology Authors: Lee TY, Kim CU, Lee P, Seo SH, Bae EH, Kim YS, Kim SH, Kim DJ Tags: Immunol Lett Source Type: research

Immune system in the pathogenesis of chronic cough.
Abstract Chronic cough is a common symptom of various chronic diseases. However, the vast majority of individuals with conditions that are commonly associated with cough, such as asthma and GERD, do not have chronic cough. This implies that cough reflex sensitivities differ among individuals. It is known that in the pathogenesis of cough, the nervous system plays a vital role. Recently more information about the role of the immune system and its interaction with the nervous system in the pathogenesis of cough has appeared in the literature. The aim of this article is to review the most recent data about the role o...
Source: Immunology Letters - December 31, 2019 Category: Allergy & Immunology Authors: Tamasauskiene L, Brigita S Tags: Immunol Lett Source Type: research

Bispecific antibody activated T cells: A newly developed T cells with enhanced proliferation ability and cytotoxicity.
Abstract Adoptive cell therapy using ex vivo expanded lymphocytes has shown remarkable efficacy in tumor immunotherapy recently. Among various transfused immune cells, T lymphocytes are the most widely used since they are critical mediators of the immune system and have the capacity to kill tumor cells. However, there are drawbacks in the expanded T cells for transfusion including limited cytotoxicity, limited proliferation and lack of specificity. To improve the quality of these ex vivo expanded T cells, we have designed a new method to expand a group of T cells which are named bispecific antibodies activated T c...
Source: Immunology Letters - December 31, 2019 Category: Allergy & Immunology Authors: Guo Q, Zhang Z, Zhao P, Zou S, Li L, Li N, Sun W, Wei X, Hou L, Yang Z, Gao D Tags: Immunol Lett Source Type: research

Prohibitin 1 interacts with signal transducer and activator of transcription 3 in T-helper 17 cells.
Abstract T-helper 17 (Th17) cells are involved in the occurrence and development of several inflammation-associated diseases. Interleukin (IL)-17, the main cytokine secreted by differentiated Th17 cells, mediates immunoreactions and plays important roles in immunological diseases, including psoriasis, rheumatic arthritis, and inflammatory bowel disease. The maturation and stabilization of the differentiated Th17 cell phenotype are associated with the expression of IL-17A, which is induced by the activation of signal transducer and activator of transcription 3 (STAT3). Prohibitin 1 (PHB1) also plays an essential ro...
Source: Immunology Letters - December 31, 2019 Category: Allergy & Immunology Authors: Zhang J, Sun Z, Wu Q, Shen J Tags: Immunol Lett Source Type: research

Recovery of CD226-TIGIT+FoxP3+ and CD226-TIGIT-FoxP3+ Regulatory T cells Contributes to Clinical Remission from Active Stage in UC patients.
CONCLUSIONS: Lack of CD226 expression on FoxP3+Tregs regardless of TIGIT expression may play an important role in exhibiting their suppressive function and preventing from disease activity in UC. PMID: 31883787 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - December 26, 2019 Category: Allergy & Immunology Authors: Long Y, Wang C, Xia C, Li X, Fan C, Zhao X, Liu C Tags: Immunol Lett Source Type: research

Activation-induced surface proteins in the identification of antigen-responsive CD4 T cells.
Abstract Identification of antigen specificity of CD4 T cells is instrumental in understanding adaptive immune responses in health and disease. The high diversity of CD4 T cell repertoire combined with the functional heterogeneity of the compartment poses a challenge to the assessment of CD4 T cell responses. In spite of that, multiple technologies allow direct or indirect interrogation of antigen specificity of CD4 T cells. In the last decade, multiple surface proteins have been established as cytokine-independent surrogates of in vitro CD4 T cell activation, and have found applications in the live identification...
Source: Immunology Letters - December 24, 2019 Category: Allergy & Immunology Authors: Elias G, Ogunjimi B, Van Tendeloo V Tags: Immunol Lett Source Type: research

Anti-enolase 1antibodies from a patient with systemic lupus erythematosus accompanied by pulmonary arterial hypertension promote migration of pulmonary artery smooth muscle cells.
CONCLUSION: Patients with SLE may possess autoantibodies to enolase 1 which stimulate the migration of PASMCs and are likely to play a role in the progression of PAH. PMID: 31866401 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - December 19, 2019 Category: Allergy & Immunology Authors: Kato Y, Kasama T, Soejima M, Kubota T Tags: Immunol Lett Source Type: research

Heterogeneity of Human Serum Antibody Responses to P. gingivalis in Periodontitis: Effects of Age, Race/Ethnicity, and Sex.
This report examined antigenic diversity of P. gingivalis related to disease presence and patient demographics. Serum IgG antibody to P. gingivalis strains ATCC33277, FDC381, W50 (ATCC53978), W83, A7A1-28 (ATCC53977) and A7436 was measured in 426 participants [periodontally healthy (n = 61), gingivitis (N = 66) or various levels of periodontitis (N = 299)]. We hypothesized that antigenic diversity in P. gingivalis could contribute to a lack of "immunity" in the chronic infections of periodontal disease. Across the strains, the antibody levels in the oldest age group were ...
Source: Immunology Letters - December 18, 2019 Category: Allergy & Immunology Authors: Ebersole JL, Al-Sabbagh M, Dawson DR Tags: Immunol Lett Source Type: research

IL-33 changes CD25hiTregs to Th17 cells through a dendritic cell-mediated pathway.
Abstract Interleukin (IL)-33 is an alarmin factor that is highly secreted in a variety of autoimmune diseases, induces maturation of dendritic cells (DCs) and differentiation of T helper 17 (Th17) cells. As the balance between Th17 cells and regulatory T cells (Tregs) is important to maintain immune homeostasis, in this study, we investigated the effects of IL-33 on Treg cell response. We observed that direct treatment with IL-33 had no effect on Treg differentiation, whereas IL-33-matured DCs (IL33-matDCs) inhibited the differentiation of CD4+ T cells to Tregs by decreasing the expression of Foxp3. Furthermore, c...
Source: Immunology Letters - December 18, 2019 Category: Allergy & Immunology Authors: Park SH, Jung HJ, Kim TS Tags: Immunol Lett Source Type: research

The level of natural autoantibodies to IFN-gamma in varicella infections treated with antiviral drug Anaferon for Children: a pilot study.
Abstract Natural circulating antibodies (NAbs) to endogenous regulators have shown to be potential biomarkers in medicine. Due to the lack of reliable assays, only few of them have been well studied. To employ NAbs as biomarkers, an evaluation of changes over the course of a treatment is required. This paper describes our work to analyze the dynamics of NAbs titer to interferon-gamma (IFN-γ) among healthy children of different age and in patients with varicella infection receiving an antiviral drug Anaferon for children (AC, the API are highly diluted antibodies to IFN-γ) in comparison with placebo, an...
Source: Immunology Letters - December 12, 2019 Category: Allergy & Immunology Authors: Don E, van der Meide N, Egorov V, Putilovskiy M, Tarasov S Tags: Immunol Lett Source Type: research

Role of allograft inflammatory factor-1 in pathogenesis of diseases.
Abstract Allograft inflammatory factor-1 (AIF-1) is a 17 kDa calcium-binding protein produced by monocytes, macrophages, and lymphocytes; its synthesis is induced by INF-γ. The AIF-1 gene is located in the major histocompatibility complex (MHC) class III region on chromosome 6p21.3, surrounded by surface glycoprotein genes and complement cascade protein genes as well as TNF-α, TNF-β, and NF-κB genes. Increased expression of AIF-1 was observed in several diseases, including endometriosis, breast cancer, atherosclerosis, rheumatoid arthritis, and fibrosis. In this review, we summarise t...
Source: Immunology Letters - December 9, 2019 Category: Allergy & Immunology Authors: Sikora M, Kopeć B, Piotrowska K, Pawlik A Tags: Immunol Lett Source Type: research

In vivo characterization of histological and immunological response of allergic protein of Metapenaeus dobsonii using an adjuvant free BALB/c mice model.
Abstract Shrimp allergy, a common form of food allergy is an adverse immunological response to shrimp proteins. BALB/c mice was sensitized by an adjuvant free oral administration of purified tropomyosin, from Metpenaeus dobsonii to characterize intestinal histological responses and immunological protein recognition pattern as it is unpractical in human subjects. Sensitized mice with higher dose of tropomyosin expressed symptoms of anaphylaxis including puffiness around eyes and snout, no activity, tremor and convulsion after challenge. The responses of high level of sera IgE, tropomyosin specific IgE and histamine...
Source: Immunology Letters - December 3, 2019 Category: Allergy & Immunology Authors: Laly SJ, Sankar TV, Panda SK Tags: Immunol Lett Source Type: research

Breakdown of tolerance in autoimmune hepatitis: This time toxin beats virus.
PMID: 31805299 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - December 2, 2019 Category: Allergy & Immunology Authors: Christen U Tags: Immunol Lett Source Type: research

Chemical induced inflammation of the liver breaks tolerance and results in autoimmune hepatitis in Balb/c mice.
Abstract Autoimmune hepatitis (AIH) is a chronic liver disease mediated by immunity, and could lead to liver fibrosis and hepatocellular carcinoma. However, the mechanisms for breaking hepatic tolerance and driving AIH still remain elusive. We herein reported that the non-specific liver inflammation triggered by carbon tetrachloride (CCl4) recruited high numbers of CD4 + T, CD8 + T and B cells, and elevated the expression of proinflammaitory cytokines in Balb/c mice, further breaking liver tolerance and inducing autoimmune response, AIH inflammation and liver fibrosis in the presence of...
Source: Immunology Letters - November 30, 2019 Category: Allergy & Immunology Authors: Chi G, Pei JH, Ma QY, Ru YX, Feng ZH Tags: Immunol Lett Source Type: research

HCMV seropositivity is Associated with Specific Proinflammatory Immune Phenotype in Women with Implantation Failure.
Abstract HCMV coevolved with humans for millions of years and is now one of the most widespread infections worldwide. For a long time HCMV seropositivity was considered a safe clinical condition. In recent decades both clinical observations and research results indicated that the very presence of HCMV in human organism specifically influences immune system and may affect reproduction as a process greatly dependent on immune cells function. Anti-HCMV IgG, IgG avidity, lymphocyte subsets as well as NK cytotoxicity was investigated in 470 infertile women who were eligible for IVF/ET. 419 patients were IgG anti-HCMV-p...
Source: Immunology Letters - November 19, 2019 Category: Allergy & Immunology Authors: Dons'koi BV, Tutchenko TM, Chernyshov VP, Stepaniuk KS Tags: Immunol Lett Source Type: research

CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy.
Abstract Chemokines are small molecules called "chemotactic cytokines" and regulate many processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal rearrangement, physiology, migration during development, and host immune responses. These proteins bind to their corresponding 7-membrane G-protein-coupled receptors. Chemokines and their receptors are anti-inflammatory factors in autoimmune conditions, so consider as potential targets for neutralization in such diseases. They also express by cancer cells and function as angiogenic factors, and/or survival/growth factors that enhan...
Source: Immunology Letters - November 17, 2019 Category: Allergy & Immunology Authors: Mousavi A Tags: Immunol Lett Source Type: research

Adaptive threshold-stochastic resonance (AT-SR) in MHC clusters on the cell surface.
ich L Abstract Highly conserved 2D receptor clusters (membrane rafts) of immunological signaling molecules with MHCI and MHCII antigens as their cores have been observed in the past on the surface of T- and B-cell lines of lymphoid origin, as well as on cells from patients with colon tumor and Crohn's disease. Conservativity is related to the ever presence of MHCI molecules. Although they are suspected to play a role in maintaining these clusters and facilitating transmembrane signaling, their exact role has been left largely enigmatic. Here we are suggesting stochastic resonance (SR), or "noise-assisted sign...
Source: Immunology Letters - November 15, 2019 Category: Allergy & Immunology Authors: Bene L, Bagdány M, Damjanovich L Tags: Immunol Lett Source Type: research

Advances in immunomodulatory therapy for severe acute pancreatitis.
This article reviews the development of SAP immunoregulation and its recent progress. PMID: 31730775 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - November 12, 2019 Category: Allergy & Immunology Authors: Munir F, Jamshed MB, Shahid N, Hussain HM, Muhammad SA, Mamun AA, Zhang Q Tags: Immunol Lett Source Type: research

The autoimmune response elicited by mouse hepatitis virus (mhv-a59) infection is modulated by liver tryptophan-2,3-dioxygenase (tdo).
THE AUTOIMMUNE RESPONSE ELICITED BY MOUSE HEPATITIS VIRUS (MHV-A59) INFECTION IS MODULATED BY LIVER TRYPTOPHAN-2,3-DIOXYGENASE (TDO). Immunol Lett. 2019 Nov 11;: Authors: Vega MD, Aparicio JL, Mandour MF, Retegui LA Abstract In a previous work we demonstrated that inhibition of mouse indoleamine 2,3-dioxygenase (IDO) by methyltryptophan (MT) exacerbated the pathological actions of mouse hepatitis virus (MHV-A59) infection, suggesting that tryptophan (TRP) catabolism was involved in viral effects. Since there is a second enzyme that dioxygenates TRP, tryptophan-2, 3-dioxygenase (TDO), which is mainly l...
Source: Immunology Letters - November 11, 2019 Category: Allergy & Immunology Authors: Vega MD, Aparicio JL, Mandour MF, Retegui LA Tags: Immunol Lett Source Type: research

Granulysin: The attractive side of a natural born killer.
Abstract First discovered in the 1980's, granulysin has until recently been thought of solely as an effector molecule present within cytotoxic immune cell populations, and involved in the direct killing of pathogens and infected or transformed eukaryotic cells. However, recent research has suggested an additional role of granulysin, in particular the 15 kDa isoform. While 9 kDa granulysin is broadly cytotoxic and capable of the direct killing of bacteria and other pathogens, the 15 kDa isoform of this molecule has been shown to function as an immune 'alarmin', causing the maturation and migrat...
Source: Immunology Letters - November 11, 2019 Category: Allergy & Immunology Authors: Sparrow E, Bodman-Smith MD Tags: Immunol Lett Source Type: research

Abnormal Activation of Myeloid Dendritic Cells in JORRP Patients and Associated with Disease Activity.
CONCLUSION: Our results demonstrate an abnormal TLR2 and TLR4 expression in mDCs may contribute to suppressive immune response to HPV6 or HPV11 infection and associated with disease activity in JORRP patients. PMID: 31726188 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - November 11, 2019 Category: Allergy & Immunology Authors: Wu X, Xiao Y, Ma L, Pan X, Wang J Tags: Immunol Lett Source Type: research

Enhanced antibody response to ovalbumin coupled to poly-dispersed acid functionalized single walled carbon nanotubes.
Abstract Activated mouse B cells as compared to the resting B cells are known to internalize substantially more acid-functionalized single walled carbon nanotubes (AF-SWCNTs). It was hypothesized that the antigens coupled to AF-SWCNTs would also be taken up more efficiently by B cells. Further the enhanced uptake of the antigen by B cells may facilitate antigen presentation by B cells resulting in a better antibody response. Aim of this study was to test this hypothesis. Ovalbumin was chemically coupled to AF-SWCNTs that yielded a coupled product that had 0.08% of all carbon atoms in AF-SWCNTs occupied by ovalbumi...
Source: Immunology Letters - November 11, 2019 Category: Allergy & Immunology Authors: Dutt TS, Saxena RK Tags: Immunol Lett Source Type: research

Evaluation of ERAP1 gene single nucleotide polymorphisms in immunomodulation of pro-inflammatory and anti-inflammatory cytokines profile in ankylosing spondylitis.
CONCLUSIONS: This study represented the association of ERAP1 gene rs30187 and rs2287987 polymorphism with the risk of AS. Additionally, it appears that rs30187 polymorphism may be involved in the immunomodulation of the IL-17/IL-23 pathway in the AS disease. PMID: 31711818 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - November 8, 2019 Category: Allergy & Immunology Authors: Babaie F, Mohammadi H, Hemmatzadeh M, Ebrazeh M, Torkamandi S, Yousefi M, Hajaliloo M, Rezaiemanesh A, Salimi S, Salimi R, Safarzadeh E, Baradaran B, Babaloo Z Tags: Immunol Lett Source Type: research

The role of Toll-like receptors in myocardial toxicity induced by doxorubicin.
Abstract Doxorubicin is an effective antitumor drug commonly used in the treatment of a wide variety of cancers. However, doxorubicin may cause cardiac toxicity, which can cause congestive heart failure in severe cases, and this seriously limits its clinical application. It is believed that doxorubicin promotes the formation of reactive oxygen species, inducing oxidative stress, and at the same time, reduces the content of antioxidant substances in cardiac tissues, causing adverse effects. Toll-like receptors (TLRs) are biomolecules expressed on the surfaces of macrophages, dendritic cells, and epithelial cells th...
Source: Immunology Letters - November 7, 2019 Category: Allergy & Immunology Authors: Xinyong C, Zhiyi Z, Lang H, Peng Y, Xiaocheng W, Ping Z, Liang S Tags: Immunol Lett Source Type: research

HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis.
Abstract The aetiology of multiple sclerosis (MS) is as yet poorly understood. Multiple mechanisms in different disease stages are responsible for immunopathology in MS. HLA Class II DR2b (DRB1*1501 β, DRA1*0101 α) is the strongest genetic risk factor for MS. Remnants of ancient retroviruses in the human genome, termed human endogenous retroviruses (HERV), and Epstein-Barr virus (EBV) infection are also associated with MS. In silico analyses of human endogenous retroviral envelope (HERV env) proteins and three myelin proteins that are principal targets of an autoimmune response in MS showed sequence sim...
Source: Immunology Letters - November 2, 2019 Category: Allergy & Immunology Authors: Ramasamy R, Mohammed F, Meier UC Tags: Immunol Lett Source Type: research

Site Specific Microbiome of Leishmania Parasite and its Cross-talk with Immune Milieu.
Abstract Microbiota consists of commensal, symbiotic and pathogenic microorganisms found in all multicellular organisms. These micro-organisms are found in or on many parts of the body, including the intestinal tract, skin, mouth, and the reproductive tract. This review focuses on interplay of site specific microbiota, vector microbiota along with immune response and severity of Leishmaniasis. Herein, we have reviewed and summarized the counter effect of microbiome post infection with the Leishmania parasite. We have studied skin microbiome along with the gut microbiome of sand-fly which is the vector for transmis...
Source: Immunology Letters - October 30, 2019 Category: Allergy & Immunology Authors: Misra P, Singh S Tags: Immunol Lett Source Type: research

Mucosal vaccines: Strategies and challenges.
Abstract Mucosal immunization has potential benefits over conventional parenteral immunization, eliciting immune defense in both mucosal and systemic tissue for protecting from pathogen invasion at mucosal surfaces. To provide a first line of protection at these entry ports, mucosal vaccines have been developed and hold a significant promise for reducing the burden of infectious diseases. However, until very recently, only limited mucosal vaccines are available. This review summarizes recent advances in selected aspects regarding mucosal vaccination, including appropriate administration routes, reasonable formulat...
Source: Immunology Letters - October 25, 2019 Category: Allergy & Immunology Authors: Li M, Wang Y, Sun Y, Cui H, Zhu SJ, Qiu HJ Tags: Immunol Lett Source Type: research

CART Manufacturing Process and Reasons for Academy-Pharma Collaboration.
o M, Juan M Abstract The success of genetically engineered T-cells modified with a chimeric antigen receptor as an adoptive cell immunotherapy and the subsequent last regulatory approvals of products based on this therapy are leading to a crescent number of both academic and pharmaceutical industry clinical trials testing new approaches of this "living drugs". The aim of this review is to outline the latest developments and regulatory considerations in this field, with a particular emphasis to differences and similarities between academic and industry approaches and the role they should play to coexist a...
Source: Immunology Letters - October 25, 2019 Category: Allergy & Immunology Authors: Egri N, de Landazuri IO, Bartolomé CS, Ortega JR, Español-Rego M, Juan M Tags: Immunol Lett Source Type: research

Granzyme B-expressing Treg cells are enriched in colorectal cancer and present the potential to eliminate autologous T conventional cells: Short title: granzyme B-expressing Treg cells in colorectal cancer.
In this study, we investigated the cytotoxic aspect of Treg cells in CRC patients. Data showed that tumor-infiltrating FOXP3+ Treg cells expressed granzyme B immediately following resection, indicating that granzyme B-expressing Treg cells were present directly ex vivo. In the tumor-associated lymph nodes (LNs) and circulating lymphocytes, however, granzyme B-expressing Treg cells were only scarcely found. We then attempted to stimulate granzyme B expression in circulating Treg cells. Granzyme B upregulation in Treg cells could not be activated by standard T cell receptor (TCR) activation through anti-CD3/CD28 and IL-2 but...
Source: Immunology Letters - October 24, 2019 Category: Allergy & Immunology Authors: Sun B, Liu M, Cui M, Li T Tags: Immunol Lett Source Type: research

PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.
This study was performed on 120 RA patients who were referred to the Rheumatology Research Centre, Shariati Hospital (Tehran, Iran), and 120 healthy controls. Genomic DNA was extracted and genotyped for 1858C/T PTPN22 gene SNP using the PCR-RFLP technique. Serum levels of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ as well as Anti-CCP and RF was measured by ELISA method. RESULTS: Results showed that 1858C/T PTPN22 SNP significantly (P =  0.007, OR = 2.321, 95% CI = 1.063-5.067) associated with RA. The 1858 T allele frequency was also significantly increased in ...
Source: Immunology Letters - October 24, 2019 Category: Allergy & Immunology Authors: Ghorban K, Ezzeddini R, Eslami M, Yousefi B, Moghaddam BS, Tahoori MT, Dadmanesh M, Farrokhi AS Tags: Immunol Lett Source Type: research

Associations of polymorphisms in interleukins with tuberculosis: evidence from a meta-analysis.
CONCLUSIONS: Collectively, this meta-analysis proved that IL-2 rs2069762, IL-4 rs2243250, IL-6 rs1800795, IL-8 rs4073, IL-10 rs1800871 and IL-10 rs1800896 polymorphisms may confer susceptibility to TB, especially for Asians. PMID: 31669382 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - October 24, 2019 Category: Allergy & Immunology Authors: Chen J, Ma A Tags: Immunol Lett Source Type: research

Heat-killed probiotic regulates the body's regulatory immunity to attenuate subsequent experimental autoimmune arthritis.
This study indicates that pre-administration of h-L. reuteri can alleviate the CIA in mice and may serve as a promising strategy for autoimmune disease prevention. PMID: 31644891 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - October 20, 2019 Category: Allergy & Immunology Authors: Jia H, Ren S, Wang X Tags: Immunol Lett Source Type: research

Repeated intravenous injection of adipose tissue derived mesenchymal stem cells enhances Th1 immune responses in Leishmania major-infected BALB/c mice.
Abstract Mesenchymal stem cell (MSCs) therapy are among new strategies that are used to combat infections through immunomodulation. Cell number, route and frequency of injection and the duration of exposure to the infectious agent are of the main factors to determine the effectiveness of cell therapy. The current study was aimed to assess the effect of multiple intravenous (i.v.) injection of adipose tissue derived (AD)-MSCs on immune response of Leishmania (L.) major-infected BALB/c mice. Therefore, infected mice received AD-MSCs four times during the early phase of infection through i.v. route. They were then mo...
Source: Immunology Letters - October 14, 2019 Category: Allergy & Immunology Authors: Zanganeh E, Soudi S, Zavaran Hosseini A, Khosrojerdi A Tags: Immunol Lett Source Type: research

Cancer immunotherapy with lymphocytes genetically engineered with T cell receptors for solid cancers.
Abstract Adoptive transfer of T cells genetically engineered with chimeric antigen receptors (CAR-T cells) have proven to be highly effective for treating CD19+ B cell-derived hematologic malignancies. However, due to the lack of ideal tumor surface antigens, CAR-T cell therapy has limited success in treating solid tumors. T cells genetically engineered with T cell receptors (TCR-T cells) recognize intracellular and cell-surface antigens in the context of major histocompatibility complex (MHC) presentation and thus have the potential to access much more target antigens than CAR-T cells, providing great promise in ...
Source: Immunology Letters - October 6, 2019 Category: Allergy & Immunology Authors: Chen L, Qiao D, Wang J, Tian G, Wang M Tags: Immunol Lett Source Type: research

A combination regimen of low-dose bortezomib and rapamycin prolonged the graft survival in a murine allogeneic islet transplantation model.
In this study, we showed that the short-term combination treatment of low-dose bortezomib and rapamycin significantly prolonged the survival of islet allografts. Short-term treatment of low-dose (0.05 mg/kg or 0.1 mg/kg) bortezomib reduced the MHC class II expression in dendritic cells (DCs) of alloantigen-sensitized mice, and prolonged the islet allograft survival for up to 50 days in diabetic mice. Notably, when bortezomib was combined with rapamycin, it induced islet-specific immunological tolerance which allowed the acceptance of a second graft without additional immunosuppression. This regimen dramatical...
Source: Immunology Letters - October 5, 2019 Category: Allergy & Immunology Authors: Hong SH, Kim K, Shin JS, Chung H, Park CG Tags: Immunol Lett Source Type: research

CD3-CD56+ NK cells display an inflammatory profile in RR-MS patients.
In this study, activating and inhibitory receptor expressions and IL-22 levels of NK cells were investigated in RR-MS patients with or without IFN-β therapy. Activating receptor expression and IL-22 levels of NK cells were increased in RR-MS patients under IFN-β therapy. Elevated NK cells with activating profile and increased IL-22 under IFN-β therapy suggest that IFN-β treatment might direct NK cells toward a pro-inflammatory status. PMID: 31589897 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - October 4, 2019 Category: Allergy & Immunology Authors: Tahrali I, Kucuksezer UC, Akdeniz N, Altintas A, Uygunoglu U, Cetin EA, Deniz G Tags: Immunol Lett Source Type: research

Genetic Mutations and Immunological Features of Severe Combined Immunodeficiency Patients in Iran.
CONCLUSION: Current findings suggest that candidate gene approach based on patient's immunophenotype might accelerate molecular diagnosis of SCID patients. Candidate gene selection should be done according to the frequency of disease-causing genes in different populations. Targeted gene panel, WES and WGS methods can be used for the cases which are not diagnosed using this method. PMID: 31589898 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - October 4, 2019 Category: Allergy & Immunology Authors: Shahbazi Z, Yazdani R, Shahkarami S, Shahbazi S, Hamid M, Sadeghi-Shabestari M, Momen T, Aleyasin S, Esmaeilzadeh H, Darougar S, Delavari S, Mahdaviani SA, Ahanchian H, Behmanesh F, Kiaee F, Shariat M, Keramatipour M, Rezaei N, Abolhassani H, Parvaneh N, Tags: Immunol Lett Source Type: research

Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.
Abstract Recently, clinical studies using anti-immune checkpoint molecule antibodies have been successful in solid tumors, such as melanoma and non-small cell lung cancers. However, pancreatic cancers are still intractable and difficult to treat once recurrence or metastasis occurs; thus, novel combined use of immune checkpoint blockade (ICB) with molecular targeted drugs is considered a therapeutic option. Previously, we developed a novel humanized MHC-double knockout (dKO) NOG mouse model and demonstrated that an anti-PD-1 antibody or a STAT3 inhibitor showed anti-tumor effects through an immunological mechanism...
Source: Immunology Letters - October 3, 2019 Category: Allergy & Immunology Authors: Ashizawa T, Iizuka A, Maeda C, Tanaka E, Kondou R, Miyata H, Sugino T, Kawata T, Deguchi S, Mitsuya K, Hayashi N, Asai A, Ito M, Yamaguchi K, Akiyama Y Tags: Immunol Lett Source Type: research

Hypoxia enhances IL-10-producing B cell generation through upregulating high-mobility group B1 on tumor cell-released autophagosomes.
Abstract As common features of human solid tumors, hypoxia and nutrient starvation play multifaceted roles in cancer progress. However, the mechanisms are far from clear. Our previous work has indicated that tumor cell-released autophagosomes (TRAPs) are sufficient to suppress anti-tumor immune response in mouse by inducing IL-10-producing B cells through high-mobility group B1 (HMGB1). Here, we hypothesized that hypoxia or starvation might exert immunosuppressive effect through upregulating HMGB1 on TRAPs. We found that HMGB1 on TRAPs from human hepatocellular carcinoma cell line HepG2 played a significant role i...
Source: Immunology Letters - September 27, 2019 Category: Allergy & Immunology Authors: Zhang Y, Pan N, Sheng Y, Zhou M, Wen Z, Chen Y, Huang F, Wang LX Tags: Immunol Lett Source Type: research

IL-21 and IL-21-producing T cells are involved in multiple sclerosis severity and progression.
Abstract Multiple sclerosis is a common neuroinflammatory disease of the central nervous system causing nervous system defects and severe physical disability. IL-21 is a proinflammatory cytokine produced mainly by Th-17 and Tfh cells which its exact role in MS was not yet clearly understood. In the present study we aimed to investigate the possible correlation of IL-21 gene expression, methylation, and its serum levels with MS severity and progression. The results showed that IL-21 mRNA level and serum level were significantly increased in patient group compared with control group (p = 0.02 and p 
Source: Immunology Letters - September 20, 2019 Category: Allergy & Immunology Authors: Gharibi T, Hosseini A, Marofi F, Oraei M, Jahandideh S, Abdollahpour-Alitappeh M, Hashemi V, Motallebnezhad M, Babaloo Z, Baradaran B Tags: Immunol Lett Source Type: research

FoxO1 controls the expansion of pre-B cells by regulating the expression of interleukin 7 receptor α chain and its signal pathway.
In conclusion, FoxO1 regulates the expansion of pre-B cells by regulating the expression of IL-7Rα and its signal transduction. PMID: 31545960 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - September 20, 2019 Category: Allergy & Immunology Authors: Li Z, Zhang N, Hui F, Zahid D, Zheng W, Xu X, Li W Tags: Immunol Lett Source Type: research

Immunomodulatory effect of thymopentin on lymphocytes from supramammary lymph nodes of dairy cows.
This study was to explore the underlying mechanisms by investigating the immunomodulatory effect of TP 5 on SMLN lymphocytes. Lymphocyte proliferation, cell cycle distribution and cytokine mRNA expression were determined by MTT, FCM and RT-qPCR, respectively. Laser scanning confocal microscope (LSCM) was used to observe the binding between TP 5 and SMLN lymphocytes. Moreover, RNA-sequencing (RNA-seq) was performed to observe the difference between the lymphocytes with and without TP 5 treatment. The results showed that TP 5 significantly promoted lymphocyte proliferation, accelerated cell cycle progression, and enhanced mR...
Source: Immunology Letters - September 11, 2019 Category: Allergy & Immunology Authors: Guan R, Xu W, Yuan L, Wang Y, Cui X, Hu S Tags: Immunol Lett Source Type: research

Melatonin protects against lipopolysaccharide-induced epididymitis in sheep epididymal epithelial cells in vitro.
PMID: 31491433 [PubMed - as supplied by publisher] (Source: Immunology Letters)
Source: Immunology Letters - September 3, 2019 Category: Allergy & Immunology Authors: Ge WB, Xiao LF, Duan HW, Li ZS, Jiang YT, Yang SS, Hu JJ, Zhang Y, Zhao XX Tags: Immunol Lett Source Type: research

ATP and adenosine: role in the immunopathogenesis of rheumatoid arthritis.
Abstract Rheumatoid arthritis (RA) is a classic inflammatory autoimmune disease. Local joint destruction and extra-articular manifestations of RA deeply compromise the life quality of the affected patients. RA immunopathogenesis depends on continuous immunogenic activation in which the purinergic system participates. The purinergic system comprises the signaling and metabolism of purines such as adenosine triphosphate (ATP) and adenosine. ATP signaling is involved in the activation and maintenance of the inflammatory state of RA through the activation of P2 × 7 and the production of cytokines, ...
Source: Immunology Letters - August 31, 2019 Category: Allergy & Immunology Authors: da Silva JLG, Passos DF, Bernardes VM, Leal DBR Tags: Immunol Lett Source Type: research