Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination
Immunol Lett. 2024 Mar 11;267:106851. doi: 10.1016/j.imlet.2024.106851. Online ahead of print.ABSTRACTBacillus Calmette-Guérin (BCG) vaccination induces memory characteristics in innate immune cells and their progenitors, a process called trained immunity mediated by epigenetic and metabolic reprogramming. Cholesterol synthesis plays an amplifying role in trained immunity through mevalonate release. Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, can inhibit cholesterol synthesis. We explored their effects on trained immunity induced by BCG in a placebo-controlled clinical study (NL74082.091.20) in young...
Source: Immunology Letters - March 13, 2024 Category: Allergy & Immunology Authors: Ozlem Bulut Gizem Kilic Priya A Debisarun Rutger Jan R öring Sarah Sun Manon Kolkman Esther van Rijssen Jaap Ten Oever Hans Koenen Luis Barreiro Jorge Dom ínguez-Andrés Mihai G Netea Source Type: research

Alendronate modulates cytokine responses in healthy young individuals after bcg vaccination
Immunol Lett. 2024 Mar 11:106851. doi: 10.1016/j.imlet.2024.106851. Online ahead of print.ABSTRACTBacillus Calmette-Guérin (BCG) vaccination induces memory characteristics in innate immune cells and their progenitors, a process called trained immunity mediated by epigenetic and metabolic reprogramming. Cholesterol synthesis plays an amplifying role in trained immunity through mevalonate release. Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, can inhibit cholesterol synthesis. We explored their effects on trained immunity induced by BCG in a placebo-controlled clinical study (NL74082.091.20) in young, he...
Source: Immunology Letters - March 13, 2024 Category: Allergy & Immunology Authors: Ozlem Bulut Gizem Kilic Priya A Debisarun Rutger Jan R öring Sarah Sun Manon Kolkman Esther van Rijssen Jaap Ten Oever Hans Koenen Luis Barreiro Jorge Dom ínguez-Andrés Mihai G Netea Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Apr;266:106843. doi: 10.1016/j.imlet.2024.106843. Epub 2024 Feb 23.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Apr;266:106843. doi: 10.1016/j.imlet.2024.106843. Epub 2024 Feb 23.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Apr;266:106843. doi: 10.1016/j.imlet.2024.106843. Epub 2024 Feb 23.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Apr;266:106843. doi: 10.1016/j.imlet.2024.106843. Epub 2024 Feb 23.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Apr;266:106843. doi: 10.1016/j.imlet.2024.106843. Epub 2024 Feb 23.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research

Corrigendum to Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice [Immunology Letters 263 (2023) 113-122 /IMLET_6819]
Immunol Lett. 2024 Feb 23;266:106843. doi: 10.1016/j.imlet.2024.106843. Online ahead of print.NO ABSTRACTPMID:38401398 | DOI:10.1016/j.imlet.2024.106843 (Source: Immunology Letters)
Source: Immunology Letters - February 24, 2024 Category: Allergy & Immunology Authors: Hong Liu Source Type: research