Corrigendum to "Identification and suppression of epidermal growth factor receptor variant III signaling in fibroblast-like synoviocytes from aggressive rheumatoid arthritis by the mimotope" [Immunology Letters 198 (2018) 74-80]
Immunol Lett. 2023 Aug 8;261:56-57. doi: 10.1016/j.imlet.2023.07.010. Online ahead of print.NO ABSTRACTPMID:37562070 | DOI:10.1016/j.imlet.2023.07.010 (Source: Immunology Letters)
Source: Immunology Letters - August 10, 2023 Category: Allergy & Immunology Authors: Jianying Niu Changhong Li Yinji Jin Rui Xing Lin Sun Ruohan Yu Leilei Jian Xiangyuan Liu Lin Yang Source Type: research
Corrigendum to "Identification and suppression of epidermal growth factor receptor variant III signaling in fibroblast-like synoviocytes from aggressive rheumatoid arthritis by the mimotope" [Immunology Letters 198 (2018) 74-80]
Immunol Lett. 2023 Aug 8;261:56-57. doi: 10.1016/j.imlet.2023.07.010. Online ahead of print.NO ABSTRACTPMID:37562070 | DOI:10.1016/j.imlet.2023.07.010 (Source: Immunology Letters)
Source: Immunology Letters - August 10, 2023 Category: Allergy & Immunology Authors: Jianying Niu Changhong Li Yinji Jin Rui Xing Lin Sun Ruohan Yu Leilei Jian Xiangyuan Liu Lin Yang Source Type: research
Corrigendum to "Identification and suppression of epidermal growth factor receptor variant III signaling in fibroblast-like synoviocytes from aggressive rheumatoid arthritis by the mimotope" [Immunology Letters 198 (2018) 74-80]
Immunol Lett. 2023 Aug 8;261:56-57. doi: 10.1016/j.imlet.2023.07.010. Online ahead of print.NO ABSTRACTPMID:37562070 | DOI:10.1016/j.imlet.2023.07.010 (Source: Immunology Letters)
Source: Immunology Letters - August 10, 2023 Category: Allergy & Immunology Authors: Jianying Niu Changhong Li Yinji Jin Rui Xing Lin Sun Ruohan Yu Leilei Jian Xiangyuan Liu Lin Yang Source Type: research
Elevated circulating CD19 < sup > + < /sup > CD24 < sup > hi < /sup > CD38 < sup > hi < /sup > B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy
In conclusion, CD19+CD24hiCD38hi B cells were expanded but functionally impaired in IMN patients. Their altered pro-inflammatory cytokine profile may contribute to the pathogenesis of IMN.PMID:37553031 | DOI:10.1016/j.imlet.2023.08.001 (Source: Immunology Letters)
Source: Immunology Letters - August 8, 2023 Category: Allergy & Immunology Authors: Bishun Deng Li Deng Miao Liu Ziling Zhao Huijie Huang Xiaoxin Tu Enyu Liang Ruimin Tian Xiaowan Wang Rongrong Wang Haibiao Lin Yongyi Yu Anping Peng Peng Xu Kun Bao Min He Source Type: research
Elevated circulating CD19 < sup > + < /sup > CD24 < sup > hi < /sup > CD38 < sup > hi < /sup > B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy
In conclusion, CD19+CD24hiCD38hi B cells were expanded but functionally impaired in IMN patients. Their altered pro-inflammatory cytokine profile may contribute to the pathogenesis of IMN.PMID:37553031 | DOI:10.1016/j.imlet.2023.08.001 (Source: Immunology Letters)
Source: Immunology Letters - August 8, 2023 Category: Allergy & Immunology Authors: Bishun Deng Li Deng Miao Liu Ziling Zhao Huijie Huang Xiaoxin Tu Enyu Liang Ruimin Tian Xiaowan Wang Rongrong Wang Haibiao Lin Yongyi Yu Anping Peng Peng Xu Kun Bao Min He Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways
We report that GM-CSF similarly elevated the expression of CD80 and ICAM-1 and reduced HLA-DR levels on both myeloid cell subsets. However, GM-CSF increased the percentage of macrophages expressing surface IL-15 but reduced the proportion of monocytes carrying surface IL-15. Moreover, GM-CSF significantly increased the secretion of IL-4, IL-6, TNF, CXCL10, and IL-27 by macrophages while reducing the secretion of IL-4 and CXCL10 by monocytes. We show that GM-CSF triggered ERK1/2, STAT3, STAT5, and SAPK/JNK pathways in both myeloid subsets. Using a pharmacological inhibitor (U0126) preventing ERK phosphorylation, we demonstr...
Source: Immunology Letters - July 29, 2023 Category: Allergy & Immunology Authors: Negar Farzam-Kia Ana Carmena Moratalla Florent Lema ître Annie Levert Sandra Da Cal Clara Margarido Yves Carpentier Solorio Nathalie Arbour Source Type: research
Disturbance in the reconstitution of distinct T-cell subsets and the incidence of GvHD following allo-HSCT in pediatric patients with non-malignant hematological disorders
CONCLUSION: Our findings suggest a possible relationship between the influence of acute GvHD and its prevention on delayed CD4 T-cell reconstitution and, reciprocally, unbalanced regeneration of CD4 and CD8 T-cell subsets in the development of chronic GvHD.PMID:37474024 | DOI:10.1016/j.imlet.2023.07.008 (Source: Immunology Letters)
Source: Immunology Letters - July 20, 2023 Category: Allergy & Immunology Authors: Shideh Namazi Bayegi Amir Ali Hamidieh Maryam Behfar Mahmood Bozorgmehr Amene Saghazadeh Nader Tajik Ali-Akbar Delbandi Farzaneh Tofighi Zavareh Samaneh Delavari Mehdi Shekarabi Nima Rezaei Source Type: research
Disturbance in the reconstitution of distinct T-cell subsets and the incidence of GvHD following allo-HSCT in pediatric patients with non-malignant hematological disorders
CONCLUSION: Our findings suggest a possible relationship between the influence of acute GvHD and its prevention on delayed CD4 T-cell reconstitution and, reciprocally, unbalanced regeneration of CD4 and CD8 T-cell subsets in the development of chronic GvHD.PMID:37474024 | DOI:10.1016/j.imlet.2023.07.008 (Source: Immunology Letters)
Source: Immunology Letters - July 20, 2023 Category: Allergy & Immunology Authors: Shideh Namazi Bayegi Amir Ali Hamidieh Maryam Behfar Mahmood Bozorgmehr Amene Saghazadeh Nader Tajik Ali-Akbar Delbandi Farzaneh Tofighi Zavareh Samaneh Delavari Mehdi Shekarabi Nima Rezaei Source Type: research
