BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice
Immunol Lett. 2023 Jun 25;260:58-67. doi: 10.1016/j.imlet.2023.06.009. Online ahead of print.ABSTRACTPathogenic Th17 cells play a key role in the pathogenesis of many autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4+T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant BTN2A2-IgG2aFc (BTN2A2-Ig) fusion protein has been shown to inhibit T cell functions in vitro, it's unclear whether BTN...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Youjiao Huang Feng Han Jiaju Li Yuandi Li Jie Gao Laijun Lai Peng Luo Min Su Rong Hu Source Type: research
Building the synapse engine to drive B lymphocyte function
Immunol Lett. 2023 Jun 25;260:68-72. doi: 10.1016/j.imlet.2023.06.010. Online ahead of print.ABSTRACTB cell receptor (BCR)-mediated antigen-specific recognition activates B lymphocytes and drives the humoral immune response. This enables the generation of antibody-producing plasma cells, the effector arm of the B cell immune response, and of memory B cells, which confer protection against additional encounters with antigen. B cells search for cognate antigen in the complex cellular microarchitecture of secondary lymphoid organs, where antigens are captured and exposed on the surface of different immune cells. While scannin...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Yolanda R Carrasco Source Type: research
BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice
Immunol Lett. 2023 Jun 25;260:58-67. doi: 10.1016/j.imlet.2023.06.009. Online ahead of print.ABSTRACTPathogenic Th17 cells play a key role in the pathogenesis of many autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4+T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant BTN2A2-IgG2aFc (BTN2A2-Ig) fusion protein has been shown to inhibit T cell functions in vitro, it's unclear whether BTN...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Youjiao Huang Feng Han Jiaju Li Yuandi Li Jie Gao Laijun Lai Peng Luo Min Su Rong Hu Source Type: research
Building the synapse engine to drive B lymphocyte function
Immunol Lett. 2023 Jun 25;260:68-72. doi: 10.1016/j.imlet.2023.06.010. Online ahead of print.ABSTRACTB cell receptor (BCR)-mediated antigen-specific recognition activates B lymphocytes and drives the humoral immune response. This enables the generation of antibody-producing plasma cells, the effector arm of the B cell immune response, and of memory B cells, which confer protection against additional encounters with antigen. B cells search for cognate antigen in the complex cellular microarchitecture of secondary lymphoid organs, where antigens are captured and exposed on the surface of different immune cells. While scannin...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Yolanda R Carrasco Source Type: research
BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice
Immunol Lett. 2023 Jun 25:S0165-2478(23)00111-6. doi: 10.1016/j.imlet.2023.06.009. Online ahead of print.ABSTRACTPathogenic Th17 cells play a key role in the pathogenesis of many autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4+ T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant BTN2A2-IgG2aFc (BTN2A2-Ig) fusion protein has been shown to inhibit T cell functions in vitro, it's unclea...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Youjiao Huang Feng Han Jiaju Li Yuandi Li Jie Gao Laijun Lai Peng Luo Min Su Rong Hu Source Type: research
