Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds
Immunol Lett. 2023 Sep 27;263:46-59. doi: 10.1016/j.imlet.2023.08.007. Online ahead of print.ABSTRACTLymphoma is a heterogeneous group of malignancies arising from lymphocytes, which poses a significant challenge in terms of diagnosis and treatment due to its diverse subtypes and underlying mechanisms. This review aims to explore the shared and distinct features of various forms of lymphoma predisposing conditions, with a focus on genetic, immunological and molecular aspects. While diseases such as autoimmune disorders, inborn errors of immunity and iatrogenic immunodeficiencies are biologically and immunologically distinc...
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: P Martijn Kolijn Anton W Langerak Source Type: research
Vitamin A and vitamin D induced nuclear hormone receptor activation and its impact on B cell differentiation and immunoglobulin production
In conclusion, the conjunctional impact of these nuclear receptor ligands on B cell functionality is important to better understand B cell dependent clinical outcomes in allergy and autoimmunity. Within this review, we hypothesise that a balance between both vitamins is of utmost importance to provide a robust humoral immune response and a better treatment of disorders characterised by dysregulated immune responses such as IgE-dependent allergy or autoimmunity such as lupus erythematosus.PMID:37774987 | DOI:10.1016/j.imlet.2023.08.006 (Source: Immunology Letters)
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: Padmavathy Ramanarayanan Guido Heine Margitta Worm Source Type: research
Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds
Immunol Lett. 2023 Sep 27;263:46-59. doi: 10.1016/j.imlet.2023.08.007. Online ahead of print.ABSTRACTLymphoma is a heterogeneous group of malignancies arising from lymphocytes, which poses a significant challenge in terms of diagnosis and treatment due to its diverse subtypes and underlying mechanisms. This review aims to explore the shared and distinct features of various forms of lymphoma predisposing conditions, with a focus on genetic, immunological and molecular aspects. While diseases such as autoimmune disorders, inborn errors of immunity and iatrogenic immunodeficiencies are biologically and immunologically distinc...
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: P Martijn Kolijn Anton W Langerak Source Type: research
Vitamin A and vitamin D induced nuclear hormone receptor activation and its impact on B cell differentiation and immunoglobulin production
In conclusion, the conjunctional impact of these nuclear receptor ligands on B cell functionality is important to better understand B cell dependent clinical outcomes in allergy and autoimmunity. Within this review, we hypothesise that a balance between both vitamins is of utmost importance to provide a robust humoral immune response and a better treatment of disorders characterised by dysregulated immune responses such as IgE-dependent allergy or autoimmunity such as lupus erythematosus.PMID:37774987 | DOI:10.1016/j.imlet.2023.08.006 (Source: Immunology Letters)
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: Padmavathy Ramanarayanan Guido Heine Margitta Worm Source Type: research
Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds
Immunol Lett. 2023 Sep 27;263:46-59. doi: 10.1016/j.imlet.2023.08.007. Online ahead of print.ABSTRACTLymphoma is a heterogeneous group of malignancies arising from lymphocytes, which poses a significant challenge in terms of diagnosis and treatment due to its diverse subtypes and underlying mechanisms. This review aims to explore the shared and distinct features of various forms of lymphoma predisposing conditions, with a focus on genetic, immunological and molecular aspects. While diseases such as autoimmune disorders, inborn errors of immunity and iatrogenic immunodeficiencies are biologically and immunologically distinc...
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: P Martijn Kolijn Anton W Langerak Source Type: research
Vitamin A and vitamin D induced nuclear hormone receptor activation and its impact on B cell differentiation and immunoglobulin production
In conclusion, the conjunctional impact of these nuclear receptor ligands on B cell functionality is important to better understand B cell dependent clinical outcomes in allergy and autoimmunity. Within this review, we hypothesise that a balance between both vitamins is of utmost importance to provide a robust humoral immune response and a better treatment of disorders characterised by dysregulated immune responses such as IgE-dependent allergy or autoimmunity such as lupus erythematosus.PMID:37774987 | DOI:10.1016/j.imlet.2023.08.006 (Source: Immunology Letters)
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: Padmavathy Ramanarayanan Guido Heine Margitta Worm Source Type: research
Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds
Immunol Lett. 2023 Sep 27;263:46-59. doi: 10.1016/j.imlet.2023.08.007. Online ahead of print.ABSTRACTLymphoma is a heterogeneous group of malignancies arising from lymphocytes, which poses a significant challenge in terms of diagnosis and treatment due to its diverse subtypes and underlying mechanisms. This review aims to explore the shared and distinct features of various forms of lymphoma predisposing conditions, with a focus on genetic, immunological and molecular aspects. While diseases such as autoimmune disorders, inborn errors of immunity and iatrogenic immunodeficiencies are biologically and immunologically distinc...
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: P Martijn Kolijn Anton W Langerak Source Type: research
Vitamin A and vitamin D induced nuclear hormone receptor activation and its impact on B cell differentiation and immunoglobulin production
In conclusion, the conjunctional impact of these nuclear receptor ligands on B cell functionality is important to better understand B cell dependent clinical outcomes in allergy and autoimmunity. Within this review, we hypothesise that a balance between both vitamins is of utmost importance to provide a robust humoral immune response and a better treatment of disorders characterised by dysregulated immune responses such as IgE-dependent allergy or autoimmunity such as lupus erythematosus.PMID:37774987 | DOI:10.1016/j.imlet.2023.08.006 (Source: Immunology Letters)
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: Padmavathy Ramanarayanan Guido Heine Margitta Worm Source Type: research
Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds
Immunol Lett. 2023 Sep 27:S0165-2478(23)00160-8. doi: 10.1016/j.imlet.2023.08.007. Online ahead of print.ABSTRACTLymphoma is a heterogeneous group of malignancies arising from lymphocytes, which poses a significant challenge in terms of diagnosis and treatment due to its diverse subtypes and underlying mechanisms. This review aims to explore the shared and distinct features of various forms of lymphoma predisposing conditions, with a focus on genetic, immunological and molecular aspects. While diseases such as autoimmune disorders, inborn errors of immunity and iatrogenic immunodeficiencies are biologically and immunologic...
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: P Martijn Kolijn Anton W Langerak Source Type: research
Vitamin A and vitamin D induced nuclear hormone receptor activation and its impact on B cell differentiation and immunoglobulin production
In conclusion, the conjunctional impact of these nuclear receptor ligands on B cell functionality is important to better understand B cell dependent clinical outcomes in allergy and autoimmunity. Within this review, we hypothesise that a balance between both vitamins is of utmost importance to provide a robust humoral immune response and a better treatment of disorders characterised by dysregulated immune responses such as IgE-dependent allergy or autoimmunity such as lupus erythematosus.PMID:37774987 | DOI:10.1016/j.imlet.2023.08.006 (Source: Immunology Letters)
Source: Immunology Letters - September 29, 2023 Category: Allergy & Immunology Authors: Padmavathy Ramanarayanan Guido Heine Margitta Worm Source Type: research
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice
Immunol Lett. 2023 Sep 19;263:33-45. doi: 10.1016/j.imlet.2023.09.009. Online ahead of print.ABSTRACTDiarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple immunogenic proteins. Based on prevalence of infections, we have formulated a pentavalent outer-membrane vesicles (POMVs) based ...
Source: Immunology Letters - September 21, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Prolay Halder Sanjib Das Suhrid Maiti Ushasi Bhaumik Moumita Dutta Goutam Chowdhury Kei Kitahara Shin-Ichi Miyoshi Asish Kumar Mukhopadhyay Shanta Dutta Hemanta Koley Source Type: research
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice
Immunol Lett. 2023 Sep 19:S0165-2478(23)00158-X. doi: 10.1016/j.imlet.2023.09.009. Online ahead of print.ABSTRACTDiarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple immunogenic proteins. Based on prevalence of infections, we have formulated a pentavalent outer-membrane vesicles (P...
Source: Immunology Letters - September 21, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Prolay Halder Sanjib Das Suhrid Maiti Ushasi Bhaumik Moumita Dutta Goutam Chowdhury Kei Kitahara Shin-Ichi Miyoshi Asish Kumar Mukhopadhyay Shanta Dutta Hemanta Koley Source Type: research
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice
Immunol Lett. 2023 Sep 19:S0165-2478(23)00158-X. doi: 10.1016/j.imlet.2023.09.009. Online ahead of print.ABSTRACTDiarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple immunogenic proteins. Based on prevalence of infections, we have formulated a pentavalent outer-membrane vesicles (P...
Source: Immunology Letters - September 21, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Prolay Halder Sanjib Das Suhrid Maiti Ushasi Bhaumik Moumita Dutta Goutam Chowdhury Kei Kitahara Shin-Ichi Miyoshi Asish Kumar Mukhopadhyay Shanta Dutta Hemanta Koley Source Type: research
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice
Immunol Lett. 2023 Sep 19:S0165-2478(23)00158-X. doi: 10.1016/j.imlet.2023.09.009. Online ahead of print.ABSTRACTDiarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple immunogenic proteins. Based on prevalence of infections, we have formulated a pentavalent outer-membrane vesicles (P...
Source: Immunology Letters - September 21, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Prolay Halder Sanjib Das Suhrid Maiti Ushasi Bhaumik Moumita Dutta Goutam Chowdhury Kei Kitahara Shin-Ichi Miyoshi Asish Kumar Mukhopadhyay Shanta Dutta Hemanta Koley Source Type: research
Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in neonatal mice
Immunol Lett. 2023 Sep 19:S0165-2478(23)00158-X. doi: 10.1016/j.imlet.2023.09.009. Online ahead of print.ABSTRACTDiarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of diarrhoea induced childhood morbidity and mortality in developing countries. Licensed vaccines providing broad spectrum protection against DEC mediated infections are not available. Outer membrane vesicles (OMVs) are microvesicles released by gram-negative bacteria during the growth phase and contain multiple immunogenic proteins. Based on prevalence of infections, we have formulated a pentavalent outer-membrane vesicles (P...
Source: Immunology Letters - September 21, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Prolay Halder Sanjib Das Suhrid Maiti Ushasi Bhaumik Moumita Dutta Goutam Chowdhury Kei Kitahara Shin-Ichi Miyoshi Asish Kumar Mukhopadhyay Shanta Dutta Hemanta Koley Source Type: research
