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MECHANISMS OF HISTAMINE RELEASE FROM MAST CELLS BEYOND THE HIGH AFFINITY IgE RECEPTOR IN SEVERE CHRONIC SPONTANEOUS URTICARIA
Immunol Lett. 2023 Nov 30:S0165-2478(23)00195-5. doi: 10.1016/j.imlet.2023.11.008. Online ahead of print.ABSTRACTThere is growing evidence suggesting that in a subset of patients with severe chronic urticaria (CSU) mast cells are activated via mechanisms that bypass the high affinity IgE receptor. This might explain why some patients do not respond at all to anti-IgE therapy (omalizumab). The present article reviews the pathogenic mechanisms able to lead to histamine release from mast cells described so far in patients with CSU. These include the activation of the coagulation cascade, the activation of the complement syste...
Source: Immunology Letters - December 2, 2023 Category: Allergy & Immunology Authors: Riccardo Asero Source Type: research

Phosphatidylserine promotes immunotherapy for airway allergy
In conclusion, the data demonstrate that PS can promote the specific immunotherapy for AR through inducing antigen specific Tr1 cells in the airway tissues.PMID:38008186 | DOI:10.1016/j.imlet.2023.11.006 (Source: Immunology Letters)
Source: Immunology Letters - November 26, 2023 Category: Allergy & Immunology Authors: Jinmei Xue Limin Suo Yunfang An Xinxin Wang Shuang Zhang Huazhen Liu Yongjin Wu Xizhuo Sun Changqing Zhao Pingchang Yang Source Type: research

Platelet dropping, bleeding and new treatment requirements in ITP patients after inactivated COVID-19 vaccination
In conclusion, the present study demonstrates that after receiving inactivated COVID-19 vaccines, ITP patients may experience platelet dropping, which may lead to new bleeding events and the requirement of a new round of treatment for ITP recurrence. As a result, platelet level monitoring is crucial for ITP patients during the vaccination, especially those with persistent ITP.PMID:38006954 | DOI:10.1016/j.imlet.2023.11.007 (Source: Immunology Letters)
Source: Immunology Letters - November 25, 2023 Category: Allergy & Immunology Authors: Xiao-Yong Zhan Hui Chen Huimin Kong Tongfei Meng Jieyu Ye Yong Liu Margaret H L Ng Liang Li Yuming Zhang Jinqi Huang Qiang Peng Chun Chen Yulong He Mo Yang Source Type: research

EDITORIAL: Mucosal Immunology Special Issue
Immunol Lett. 2023 Nov 16:S0165-2478(23)00192-X. doi: 10.1016/j.imlet.2023.11.005. Online ahead of print.NO ABSTRACTPMID:37979729 | DOI:10.1016/j.imlet.2023.11.005 (Source: Immunology Letters)
Source: Immunology Letters - November 18, 2023 Category: Allergy & Immunology Authors: Thais Garcias Moreira Ana Maria Caetano Faria Source Type: research

Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability
Immunol Lett. 2023 Nov 10:S0165-2478(23)00190-6. doi: 10.1016/j.imlet.2023.11.004. Online ahead of print.ABSTRACTAs one of the most prevalent modifications on RNA, N6-methyladenosine (m6A) has been recently found implicated in various pathological processes. Emerging studies have demonstrated the role of m6A and its writer Mettl3 in fine-tuning the immune response, which now becomes a research hotspot owing to its potential therapeutic value. However, the results are inconsistent and even contradictory, suggesting that there might be multiple Mettl3 target genes involved in different pathways. To delve deeper into the func...
Source: Immunology Letters - November 12, 2023 Category: Allergy & Immunology Authors: Yongjie Cai Ruiqing Yu Zhanqi Zhang Di Li Baicheng Yi Zhihui Feng Qiong Xu Source Type: research