In adult X-CGD patients, regulatory T cells are expanded while activated T cells display a NOX2-independent ROS increase
Immunol Lett. 2024 Feb 1;266:106839. doi: 10.1016/j.imlet.2024.106839. Online ahead of print.ABSTRACTThe X-linked chronic granulomatous disease (X-CGD), a rare genetic disease characterised by recurrent infections, is caused by mutations of NOX2. Significant proportions of X-CGD patients display signs of immune dysregulation. Regulatory T cells (Tregs) are CD4+T lymphocytes that expand in active inflammation and prevent autoimmune disorders. Here we asked whether X-CGD is associated to Treg dysfunctions in adult patients. To this aim, the frequency of Tregs was analysed through intracellular flow cytometry in a cohort of a...
Source: Immunology Letters - February 3, 2024 Category: Allergy & Immunology Authors: Ilenia Cammarata Valeria Pinna Ilenia Pacella Ivano Rotella Annarosa Soresina Raffaele Badolato Alessandro Plebani Claudio Pignata Emilia Cirillo Anna Maria Zicari Francesco Violi Roberto Carnevale Lorenzo Loffredo Silvia Piconese Source Type: research
IL-38 in Beh çet's disease: Gene expression in bronchoalveolar lavage from patients having pulmonary involvement
Immunol Lett. 2024 Feb 1;266:106840. doi: 10.1016/j.imlet.2024.106840. Online ahead of print.ABSTRACTThe etiological complexity of Behçet disease (BD), an immune-mediated rare form of vasculitis characterized by multi-organ involvement, is still elusive due to an incomplete understanding of the synergy between genetic susceptibility, environmental triggers, and an abnormal immune response. The diagnosis of BD relies on clinical symptoms. Lung inflammatory disorders are severe conditions of patients with BD, here we focus on the expression of biomarkers in BD patients with pulmonary manifestations. Aiming to identify addit...
Source: Immunology Letters - February 2, 2024 Category: Allergy & Immunology Authors: Kamel Hamzaoui Sabrine Louhaichi Mariem Salhi Fay çal Haj Sassi Ahmed Laathar Agnes Hamzaoui Source Type: research
Alterations of B-Cell subsets in Peripheral Blood from Adult Patients with Idiopathic Membranous Nephropathy
CONCLUSION: Idiopathic MN patients had specific changes in B-cell subsets proportions in peripheral blood. Further studies are needed to precisely determine the roles of B-cell subsets in MN.PMID:38278305 | DOI:10.1016/j.imlet.2024.106838 (Source: Immunology Letters)
Source: Immunology Letters - January 26, 2024 Category: Allergy & Immunology Authors: Huijing Wang Lan Lan Jiahui Wang Jianghua Chen Liang Xiao Fei Han Source Type: research
The evaluation of PD-1 and Tim-3 expression besides their related miRNAs in PBMCs of women with recurrent pregnancy loss
This study aims to evaluate the expression of the immune checkpoint molecules PD-1 and Tim-3 on circulating T cells by flow cytometry, that of mir-138 and mir-155 in PBMCs by Real-time PCR, and the concentrations of TGF-β and IP-10 in the sera of women suffering from RPL as well as of gestational age-matched healthy pregnant women by ELISA. The percentage of PD-1 or Tim-3 expressing CD8+ T cells was significantly lower in RPL patients compared to the controls, while there was no significant difference in Tim-3 expression of CD4+ T cells between the two groups. The mRNA of both the PD-1 and Tim-3 genes were downregulated i...
Source: Immunology Letters - January 24, 2024 Category: Allergy & Immunology Authors: Hamid Ahmadi Mohammad Sadegh Soltani-Zangbar Mehdi Yousefi Behzad Baradaran Saro Bromand Leili Aghebati-Maleki Julia Szekeres-Bartho Source Type: research
Could we use PD-1 and PD-L1 expression on lymphocytes and monocytes as predictive markers for prognosis of acute biliary pancreatitis?
CONCLUSIONS: Hematocrit, lymphocyte counts, CD14+HLA-DR+ cells, CD14+PD-L1+ cells, and intermediate monocytes emerged as parameters most closely associated with the severity and these parameters could be useful in predicting the severity of ABP.PMID:38199503 | DOI:10.1016/j.imlet.2024.106836 (Source: Immunology Letters)
Source: Immunology Letters - January 10, 2024 Category: Allergy & Immunology Authors: Ufuk Oguz Idiz Basak Aru Cemal Kaya Kivanc Derya Peker Cihad Tatar Mert Guler Abdurrahman Tunay Gulderen Yanikkaya Demirel Ali Osman Gurol Source Type: research
Expression of epidermal growth factor receptor (EGFR) in systemic sclerosis patients (SSc) and gastro-oesophageal reflux disease (GORD)
CONCLUSION: The EGFR hyperexpression may be due to SSc and/or reflux-related damage in patients with microscopic esophagitis. Further studies are warranted to answer open questions and provide a possible role of EGFR in terms of diagnosis, prognosis, and therapy.PMID:38171474 | DOI:10.1016/j.imlet.2023.106834 (Source: Immunology Letters)
Source: Immunology Letters - January 3, 2024 Category: Allergy & Immunology Authors: Andrea Pasta Francesco Calabrese Shirin Djahandideh Sheijani Manuele Furnari Edoardo G Giannini Federica Grillo Elisa Marabotto Luca Mastracci Giuseppe Murdaca Simone Negrini Edoardo Vincenzo Savarino Vincenzo Savarino Patrizia Zentilin Source Type: research
Expression of Epidermal Growth Factor receptor (EGFR) in Systemic Sclerosis patients (SSc) and Gastro-oesophageal Reflux Disease (GORD)
CONCLUSION: The EGFR hyperexpression may be due to SSc and/or reflux-related damage in patients with microscopic esophagitis. Further studies are warranted to answer open questions and provide a possible role of EGFR in terms of diagnosis, prognosis, and therapy.PMID:38171474 | DOI:10.1016/j.imlet.2023.106834 (Source: Immunology Letters)
Source: Immunology Letters - January 3, 2024 Category: Allergy & Immunology Authors: Andrea Pasta Francesco Calabrese Shirin Djahandideh Sheijani Manuele Furnari Edoardo G Giannini Federica Grillo Elisa Marabotto Luca Mastracci Giuseppe Murdaca Simone Negrini Edoardo Vincenzo Savarino Vincenzo Savarino Patrizia Zentilin Source Type: research
Expression of Epidermal Growth Factor receptor (EGFR) in Systemic Sclerosis patients (SSc) and Gastro-oesophageal Reflux Disease (GORD)
CONCLUSION: The EGFR hyperexpression may be due to SSc and/or reflux-related damage in patients with microscopic esophagitis. Further studies are warranted to answer open questions and provide a possible role of EGFR in terms of diagnosis, prognosis, and therapy.PMID:38171474 | DOI:10.1016/j.imlet.2023.106834 (Source: Immunology Letters)
Source: Immunology Letters - January 3, 2024 Category: Allergy & Immunology Authors: Andrea Pasta Francesco Calabrese Shirin Djahandideh Sheijani Manuele Furnari Edoardo G Giannini Federica Grillo Elisa Marabotto Luca Mastracci Giuseppe Murdaca Simone Negrini Edoardo Vincenzo Savarino Vincenzo Savarino Patrizia Zentilin Source Type: research
Expression of Epidermal Growth Factor receptor (EGFR) in Systemic Sclerosis patients (SSc) and Gastro-oesophageal Reflux Disease (GORD)
CONCLUSION: The EGFR hyperexpression may be due to SSc and/or reflux-related damage in patients with microscopic esophagitis. Further studies are warranted to answer open questions and provide a possible role of EGFR in terms of diagnosis, prognosis, and therapy.PMID:38171474 | DOI:10.1016/j.imlet.2023.106834 (Source: Immunology Letters)
Source: Immunology Letters - January 3, 2024 Category: Allergy & Immunology Authors: Andrea Pasta Francesco Calabrese Shirin Djahandideh Sheijani Manuele Furnari Edoardo G Giannini Federica Grillo Elisa Marabotto Luca Mastracci Giuseppe Murdaca Simone Negrini Edoardo Vincenzo Savarino Vincenzo Savarino Patrizia Zentilin Source Type: research
Expression of Epidermal Growth Factor receptor (EGFR) in Systemic Sclerosis patients (SSc) and Gastro-oesophageal Reflux Disease (GORD)
CONCLUSION: The EGFR hyperexpression may be due to SSc and/or reflux-related damage in patients with microscopic esophagitis. Further studies are warranted to answer open questions and provide a possible role of EGFR in terms of diagnosis, prognosis, and therapy.PMID:38171474 | DOI:10.1016/j.imlet.2023.106834 (Source: Immunology Letters)
Source: Immunology Letters - January 3, 2024 Category: Allergy & Immunology Authors: Andrea Pasta Francesco Calabrese Shirin Djahandideh Sheijani Manuele Furnari Edoardo G Giannini Federica Grillo Elisa Marabotto Luca Mastracci Giuseppe Murdaca Simone Negrini Edoardo Vincenzo Savarino Vincenzo Savarino Patrizia Zentilin Source Type: research
Expression of Epidermal Growth Factor receptor (EGFR) in Systemic Sclerosis patients (SSc) and Gastro-oesophageal Reflux Disease (GORD)
CONCLUSION: The EGFR hyperexpression may be due to SSc and/or reflux-related damage in patients with microscopic esophagitis. Further studies are warranted to answer open questions and provide a possible role of EGFR in terms of diagnosis, prognosis, and therapy.PMID:38171474 | DOI:10.1016/j.imlet.2023.106834 (Source: Immunology Letters)
Source: Immunology Letters - January 3, 2024 Category: Allergy & Immunology Authors: Andrea Pasta Francesco Calabrese Shirin Djahandideh Sheijani Manuele Furnari Edoardo G Giannini Federica Grillo Elisa Marabotto Luca Mastracci Giuseppe Murdaca Simone Negrini Edoardo Vincenzo Savarino Vincenzo Savarino Patrizia Zentilin Source Type: research
Role of G-protein-coupled estrogen receptor in the pathogenesis of chronic asthma
CONCLUSION: G-1 administration suppressed allergic airway inflammation in mice with chronic OVA asthma. GPER may be a potential therapeutic target for chronic allergic asthma.PMID:38142780 | DOI:10.1016/j.imlet.2023.12.001 (Source: Immunology Letters)
Source: Immunology Letters - December 24, 2023 Category: Allergy & Immunology Authors: Masamichi Itoga Yoshiko Ishioka Tomonori Makiguchi Hisashi Tanaka Kageaki Taima Norihiro Saito Hirofumi Tomita Sadatomo Tasaka Source Type: research
Adenine is an anti-inflammatory metabolite found to be more abundant in M-CSF over GM-CSF-differentiated human macrophages
Immunol Lett. 2023 Dec 22:S0165-2478(23)00204-3. doi: 10.1016/j.imlet.2023.12.003. Online ahead of print.ABSTRACTImmunometabolism has been unveiled in the last decade to play a major role in controlling macrophage metabolism and inflammation. There has been a constant effort to understand the immunomodulating properties of regulated metabolites during inflammation with the aim of controlling and re-wiring aberrant macrophages in inflammatory diseases. M-CSF and GM-CSF-differentiated macrophages play a key role in mounting successful innate immune responses. When a resolution phase is not achieved however, GM-CSF macrophage...
Source: Immunology Letters - December 24, 2023 Category: Allergy & Immunology Authors: Karl J Harber Thuc-Anh Nguyen Bauke V Schomakers Daan A F Heister Helga E de Vries Michel van Weeghel Jan Van den Bossche Menno P J de Winther Source Type: research
Role of G-protein-coupled estrogen receptor in the pathogenesis of chronic asthma
CONCLUSION: G-1 administration suppressed allergic airway inflammation in mice with chronic OVA asthma. GPER may be a potential therapeutic target for chronic allergic asthma.PMID:38142780 | DOI:10.1016/j.imlet.2023.12.001 (Source: Immunology Letters)
Source: Immunology Letters - December 24, 2023 Category: Allergy & Immunology Authors: Masamichi Itoga Yoshiko Ishioka Tomonori Makiguchi Hisashi Tanaka Kageaki Taima Norihiro Saito Hirofumi Tomita Sadatomo Tasaka Source Type: research
Adenine is an anti-inflammatory metabolite found to be more abundant in M-CSF over GM-CSF-differentiated human macrophages
Immunol Lett. 2023 Dec 22:S0165-2478(23)00204-3. doi: 10.1016/j.imlet.2023.12.003. Online ahead of print.ABSTRACTImmunometabolism has been unveiled in the last decade to play a major role in controlling macrophage metabolism and inflammation. There has been a constant effort to understand the immunomodulating properties of regulated metabolites during inflammation with the aim of controlling and re-wiring aberrant macrophages in inflammatory diseases. M-CSF and GM-CSF-differentiated macrophages play a key role in mounting successful innate immune responses. When a resolution phase is not achieved however, GM-CSF macrophage...
Source: Immunology Letters - December 24, 2023 Category: Allergy & Immunology Authors: Karl J Harber Thuc-Anh Nguyen Bauke V Schomakers Daan A F Heister Helga E de Vries Michel van Weeghel Jan Van den Bossche Menno P J de Winther Source Type: research
