Human toll-like receptor 8 (TLR8) in NK cells: implication for cancer immunotherapy
Immunol Lett. 2023 Jul 12:S0165-2478(23)00116-5. doi: 10.1016/j.imlet.2023.07.003. Online ahead of print.ABSTRACTToll-like receptors (TLR)s are homo- or heterodimeric proteins, whose structure and function were widely described in the antigen presenting cells (APC), such as Dendritic cells (DC). Recently, the expression and the role of TLRs in fighting against pathogens, was described also in NK cells. Their activation and functional properties can be directly and indirectly modulated by agonists for TLRs. In particular CD56bright NK cells subset, that is the most abundant NK cell subset in tissues and tumor microenvironme...
Source: Immunology Letters - July 14, 2023 Category: Allergy & Immunology Authors: Irene Veneziani Claudia Alicata Lorenzo Moretta Enrico Maggi Source Type: research
Epstein-Barr virus and genetic risk variants as determinants of T-bet < sup > + < /sup > B cell-driven autoimmune diseases
Immunol Lett. 2023 Jul 12:S0165-2478(23)00118-9. doi: 10.1016/j.imlet.2023.07.006. Online ahead of print.ABSTRACTB cells expressing the transcription factor T-bet are found to have a protective role in viral infections, but are also considered major players in the onset of different types of autoimmune diseases. Currently, the exact mechanisms driving such 'atypical' memory B cells to contribute to protective immunity or autoimmunity are unclear. In addition to general autoimmune-related factors including sex and age, the ways T-bet+ B cells instigate autoimmune diseases may be determined by the close interplay between gen...
Source: Immunology Letters - July 14, 2023 Category: Allergy & Immunology Authors: Laurens Bogers Kirsten L Kuiper Joost Smolders Jasper Rip Marvin M van Luijn Source Type: research
Human and mouse early B cell development: so similar but so different
Immunol Lett. 2023 Jul 11:S0165-2478(23)00117-7. doi: 10.1016/j.imlet.2023.07.004. Online ahead of print.ABSTRACTEarly B cell development in the bone marrow ensures the replenishment of the peripheral B cell pool. Immature B cells continuously develop from hematopoietic stem cells, in a process guided by an intricate network of transcription factors as well as chemokine and cytokine signals. Humans and mice possess somewhat similar regulatory mechanisms of B lymphopoiesis. The continuous discovery of monogenetic defects that impact early B cell development in humans substantiates the similarities and differences with B cel...
Source: Immunology Letters - July 13, 2023 Category: Allergy & Immunology Authors: Jakov Korzhenevich Iga Janowska Mirjam van der Burg Marta Rizzi Source Type: research
Human and mouse early B cell development: so similar but so different
Immunol Lett. 2023 Jul 11:S0165-2478(23)00117-7. doi: 10.1016/j.imlet.2023.07.004. Online ahead of print.ABSTRACTEarly B cell development in the bone marrow ensures the replenishment of the peripheral B cell pool. Immature B cells continuously develop from hematopoietic stem cells, in a process guided by an intricate network of transcription factors as well as chemokine and cytokine signals. Humans and mice possess somewhat similar regulatory mechanisms of B lymphopoiesis. The continuous discovery of monogenetic defects that impact early B cell development in humans substantiates the similarities and differences with B cel...
Source: Immunology Letters - July 13, 2023 Category: Allergy & Immunology Authors: Jakov Korzhenevich Iga Janowska Mirjam van der Burg Marta Rizzi Source Type: research
A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis
In conclusion, an elevated κ/λ ratio suggests long-lasting aberrant clonal plasma cell function in LOMG. Immuno-oncology-related proteomic analysis showed alterations in immunoregulatory pathways. Our findings pinpoint the FLC ratio as a biomarker for LOMG and call for further investigation of the immunoregulatory pathways in MG.PMID:37414259 | DOI:10.1016/j.imlet.2023.07.001 (Source: Immunology Letters)
Source: Immunology Letters - July 6, 2023 Category: Allergy & Immunology Authors: Chris Myllynen Joona Sarkkinen Sari Atula Pentti Tienari Eliisa Kek äläinen Sini M Laakso Source Type: research
A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis
In conclusion, an elevated κ/λ ratio suggests long-lasting aberrant clonal plasma cell function in LOMG. Immuno-oncology-related proteomic analysis showed alterations in immunoregulatory pathways. Our findings pinpoint the FLC ratio as a biomarker for LOMG and call for further investigation of the immunoregulatory pathways in MG.PMID:37414259 | DOI:10.1016/j.imlet.2023.07.001 (Source: Immunology Letters)
Source: Immunology Letters - July 6, 2023 Category: Allergy & Immunology Authors: Chris Myllynen Joona Sarkkinen Sari Atula Pentti Tienari Eliisa Kek äläinen Sini M Laakso Source Type: research
A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis
In conclusion, an elevated κ/λ ratio suggests long-lasting aberrant clonal plasma cell function in LOMG. Immuno-oncology-related proteomic analysis showed alterations in immunoregulatory pathways. Our findings pinpoint the FLC ratio as a biomarker for LOMG and call for further investigation of the immunoregulatory pathways in MG.PMID:37414259 | DOI:10.1016/j.imlet.2023.07.001 (Source: Immunology Letters)
Source: Immunology Letters - July 6, 2023 Category: Allergy & Immunology Authors: Chris Myllynen Joona Sarkkinen Sari Atula Pentti Tienari Eliisa Kek äläinen Sini M Laakso Source Type: research
A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis
In conclusion, an elevated κ/λ ratio suggests long-lasting aberrant clonal plasma cell function in LOMG. Immuno-oncology-related proteomic analysis showed alterations in immunoregulatory pathways. Our findings pinpoint the FLC ratio as a biomarker for LOMG and call for further investigation of the immunoregulatory pathways in MG.PMID:37414259 | DOI:10.1016/j.imlet.2023.07.001 (Source: Immunology Letters)
Source: Immunology Letters - July 6, 2023 Category: Allergy & Immunology Authors: Chris Myllynen Joona Sarkkinen Sari Atula Pentti Tienari Eliisa Kek äläinen Sini M Laakso Source Type: research
A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis
In conclusion, an elevated κ/λ ratio suggests long-lasting aberrant clonal plasma cell function in LOMG. Immuno-oncology-related proteomic analysis showed alterations in immunoregulatory pathways. Our findings pinpoint the FLC ratio as a biomarker for LOMG and call for further investigation of the immunoregulatory pathways in MG.PMID:37414259 | DOI:10.1016/j.imlet.2023.07.001 (Source: Immunology Letters)
Source: Immunology Letters - July 6, 2023 Category: Allergy & Immunology Authors: Chris Myllynen Joona Sarkkinen Sari Atula Pentti Tienari Eliisa Kek äläinen Sini M Laakso Source Type: research
A skewed ratio of free light chains is more common in patients with late-onset than early-onset myasthenia gravis
In conclusion, an elevated κ/λ ratio suggests long-lasting aberrant clonal plasma cell function in LOMG. Immuno-oncology-related proteomic analysis showed alterations in immunoregulatory pathways. Our findings pinpoint the FLC ratio as a biomarker for LOMG and call for further investigation of the immunoregulatory pathways in MG.PMID:37414259 | DOI:10.1016/j.imlet.2023.07.001 (Source: Immunology Letters)
Source: Immunology Letters - July 6, 2023 Category: Allergy & Immunology Authors: Chris Myllynen Joona Sarkkinen Sari Atula Pentti Tienari Eliisa Kek äläinen Sini M Laakso Source Type: research
BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice
Immunol Lett. 2023 Jun 25;260:58-67. doi: 10.1016/j.imlet.2023.06.009. Online ahead of print.ABSTRACTPathogenic Th17 cells play a key role in the pathogenesis of many autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4+T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant BTN2A2-IgG2aFc (BTN2A2-Ig) fusion protein has been shown to inhibit T cell functions in vitro, it's unclear whether BTN...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Youjiao Huang Feng Han Jiaju Li Yuandi Li Jie Gao Laijun Lai Peng Luo Min Su Rong Hu Source Type: research
Building the synapse engine to drive B lymphocyte function
Immunol Lett. 2023 Jun 25;260:68-72. doi: 10.1016/j.imlet.2023.06.010. Online ahead of print.ABSTRACTB cell receptor (BCR)-mediated antigen-specific recognition activates B lymphocytes and drives the humoral immune response. This enables the generation of antibody-producing plasma cells, the effector arm of the B cell immune response, and of memory B cells, which confer protection against additional encounters with antigen. B cells search for cognate antigen in the complex cellular microarchitecture of secondary lymphoid organs, where antigens are captured and exposed on the surface of different immune cells. While scannin...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Yolanda R Carrasco Source Type: research
BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice
Immunol Lett. 2023 Jun 25;260:58-67. doi: 10.1016/j.imlet.2023.06.009. Online ahead of print.ABSTRACTPathogenic Th17 cells play a key role in the pathogenesis of many autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4+T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant BTN2A2-IgG2aFc (BTN2A2-Ig) fusion protein has been shown to inhibit T cell functions in vitro, it's unclear whether BTN...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Youjiao Huang Feng Han Jiaju Li Yuandi Li Jie Gao Laijun Lai Peng Luo Min Su Rong Hu Source Type: research
Building the synapse engine to drive B lymphocyte function
Immunol Lett. 2023 Jun 25;260:68-72. doi: 10.1016/j.imlet.2023.06.010. Online ahead of print.ABSTRACTB cell receptor (BCR)-mediated antigen-specific recognition activates B lymphocytes and drives the humoral immune response. This enables the generation of antibody-producing plasma cells, the effector arm of the B cell immune response, and of memory B cells, which confer protection against additional encounters with antigen. B cells search for cognate antigen in the complex cellular microarchitecture of secondary lymphoid organs, where antigens are captured and exposed on the surface of different immune cells. While scannin...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Yolanda R Carrasco Source Type: research
BTN2A2-Ig protein inhibits the differentiation of pathogenic Th17 cells and attenuates EAE in mice
Immunol Lett. 2023 Jun 25;260:58-67. doi: 10.1016/j.imlet.2023.06.009. Online ahead of print.ABSTRACTPathogenic Th17 cells play a key role in the pathogenesis of many autoimmune diseases. Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is the commonly used animal model for human MS and is characterized by autoreactive CD4+T cells attacking autoantigens in the CNS and causing myelin sheath damage. Although the recombinant BTN2A2-IgG2aFc (BTN2A2-Ig) fusion protein has been shown to inhibit T cell functions in vitro, it's unclear whether BTN...
Source: Immunology Letters - June 27, 2023 Category: Allergy & Immunology Authors: Youjiao Huang Feng Han Jiaju Li Yuandi Li Jie Gao Laijun Lai Peng Luo Min Su Rong Hu Source Type: research
