Grand Total EEG Score Can Differentiate Parkinson's Disease From Parkinson-Related Disorders

Conclusion: The modified GTE score can distinguish patients with IPD from those with CBD, PSP or MSA at a cut-off score of 9 with excellent sensitivity but poor specificity. However, this score is not able to distinguish a particular form of APD from other forms of the disorder. Introduction Parkinsonian disorders comprise a heterogenous group of neurodegenerative diseases that manifest the core symptoms of parkinsonism, which include bradykinesia, rigidity, resting tremor, loss of postural reflexes, flexed posture, and freezing of gait (1–3). Idiopathic Parkinson's disease (IPD) is the second most common neurodegenerative disorder worldwide (4) and the most common disease entity in this group of disorders. Atypical parkinsonian disorders (APD), also known as “Parkinson-plus syndromes,” such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal degeneration (CBD), account for about 10–20% of parkinsonian disorders (5). APDs have more severe symptoms, exhibit more complications, progress more rapidly, and consequently lead to a shorter survival time than IPD (6–8). The differences between these forms of parkinsonian disorders in terms of prognosis and management have led to the recognition that it is important to distinguish between these disease entities. Furthermore, in the field of research, distinguishing between these disorders is vital, as firm conclusions from studies can only be ma...
Source: Frontiers in Neurology - Category: Neurology Source Type: research